---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21340'
abstract:
- lang: eng
text: Equilibrium quantum systems are often described by a gas of weakly interacting
normal modes. Bringing such systems far from equilibrium, however, can drastically
enhance mode-to-mode interactions. Understanding the resulting liquid is a fundamental
question for quantum statistical mechanics and a practical question for engineering
driven quantum devices. To tackle this question, we probe the non-equilibrium
kinetics of one-dimensional plasmons in a long chain of Josephson junctions. We
introduce multimode spectroscopy to controllably study the departure from equilibrium,
witnessing the evolution from pairwise coupling between plasma modes at weak driving
to dramatic, high-order, cascaded couplings at strong driving. Scaling to many-mode
drives, we stimulate interactions between hundreds of modes, resulting in near-continuum
internal dynamics. Imaging the resulting non-equilibrium plasmon populations,
we then resolve the nonlocal redistribution of energy in the response to a weak
perturbation—an explicit verification of the emergence of a strongly interacting,
non-equilibrium liquid of plasmons.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
acknowledgement: We thank V. Vitelli, M. Fruchart, and A. Burshstein for helpful input.
We acknowledge technical support from the Nanofabrication Facility and the MIBA
machine shop at IST Austria. This research was supported in part by grant NSF PHY-2309135
to the Kavli Institute for Theoretical Physics (KITP), by the Austrian Science Fund
(FWF) SFB F86, and by the NOMIS foundation.
article_number: eady7222
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Anton
full_name: Bubis, Anton
id: 1f6212b5-f795-11ec-9c0c-de4780302890
last_name: Bubis
- first_name: Lucia
full_name: Vigliotti, Lucia
id: 539e1e1a-e604-11ee-a1df-f02b018e5c8c
last_name: Vigliotti
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
citation:
ama: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. Non-equilibrium plasmon liquid
in a Josephson junction chain. Science Advances. 2026;12(7). doi:10.1126/sciadv.ady7222
apa: Bubis, A., Vigliotti, L., Serbyn, M., & Higginbotham, A. P. (2026). Non-equilibrium
plasmon liquid in a Josephson junction chain. Science Advances. American
Association for the Advancement of Science. https://doi.org/10.1126/sciadv.ady7222
chicago: Bubis, Anton, Lucia Vigliotti, Maksym Serbyn, and Andrew P Higginbotham.
“Non-Equilibrium Plasmon Liquid in a Josephson Junction Chain.” Science Advances.
American Association for the Advancement of Science, 2026. https://doi.org/10.1126/sciadv.ady7222.
ieee: A. Bubis, L. Vigliotti, M. Serbyn, and A. P. Higginbotham, “Non-equilibrium
plasmon liquid in a Josephson junction chain,” Science Advances, vol. 12,
no. 7. American Association for the Advancement of Science, 2026.
ista: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. 2026. Non-equilibrium plasmon
liquid in a Josephson junction chain. Science Advances. 12(7), eady7222.
mla: Bubis, Anton, et al. “Non-Equilibrium Plasmon Liquid in a Josephson Junction
Chain.” Science Advances, vol. 12, no. 7, eady7222, American Association
for the Advancement of Science, 2026, doi:10.1126/sciadv.ady7222.
short: A. Bubis, L. Vigliotti, M. Serbyn, A.P. Higginbotham, Science Advances 12
(2026).
corr_author: '1'
date_created: 2026-02-22T20:47:38Z
date_published: 2026-02-13T00:00:00Z
date_updated: 2026-02-24T07:25:34Z
day: '13'
ddc:
- '530'
department:
- _id: MaSe
- _id: AnHi
- _id: GeKa
doi: 10.1126/sciadv.ady7222
external_id:
arxiv:
- '2504.09721'
file:
- access_level: open_access
checksum: 8402f322f8f0e858b1d9aac57e306e31
content_type: application/pdf
creator: dernst
date_created: 2026-02-24T07:23:32Z
date_updated: 2026-02-24T07:23:32Z
file_id: '21353'
file_name: 2026_ScienceAdv_Bubis.pdf
file_size: 2775975
relation: main_file
success: 1
file_date_updated: 2026-02-24T07:23:32Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '7'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
status: public
title: Non-equilibrium plasmon liquid in a Josephson junction chain
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21383'
abstract:
- lang: eng
text: 'Planarian flatworms are known for their remarkable regenerative capacity;
however, the precise intercellular communication mechanisms underlying this process
remain unsolved. Here, we report the discovery and characterization of abundant
extracellular vesicles (EVs) in planarians. Using imaging and molecular analysis,
we show conservation of biogenesis, morphology, and protein composition of planarian
EVs. Environmental stressors significantly elevate EV release, indicating that
planarians dynamically regulate vesicle production. Functionally, planarian EVs
mediate intercellular communication by transferring regulatory signals: We find
that they shuttle small RNAs that effect systemic RNA interference (RNAi) throughout
the organism. Notably, gene knockdown experiments reveal a crucial role for AGO-3,
a member of the Argonaute family of proteins, in modulating the association of
small interfering RNAs with EVs, linking the intracellular RNAi machinery to EV-based
signaling. These findings highlight EVs as pivotal mediators of cell-cell communication
in planarians, with broad implications for understanding the coordination of gene
regulation and tissue regeneration in animals.'
acknowledgement: 'We thank all the Sánchez Alvarado lab members for inputs and discussions.
We are grateful to the Stowers Aquatics (particularly the Planarian team), Microscopy,
and Molecular Biology core facilities for technical contributions and method development;
e. n. lissek and A. Fujii from Oni US and S. Wang from the University of Missouri,
Kansas city, for assistance with dStORM imaging; and d. Alburty and A. Page from
innovaprep for assisting with the ntA. We also thank M. Miller for the illustrations.
This work was supported by the hhMi and Stowers institute. '
article_number: eady1461
article_processing_charge: Yes
article_type: original
author:
- first_name: Vidyanand
full_name: Sasidharan, Vidyanand
last_name: Sasidharan
- first_name: Laura
full_name: Ancellotti, Laura
last_name: Ancellotti
- first_name: Viraj
full_name: Doddihal, Viraj
id: 034e0824-174b-11ef-b32b-9366a0e70d1c
last_name: Doddihal
- first_name: Carolyn
full_name: Brewster, Carolyn
last_name: Brewster
- first_name: Frederick
full_name: Mann, Frederick
last_name: Mann
- first_name: Mary Cathleen
full_name: McKinney, Mary Cathleen
last_name: McKinney
- first_name: Joseph
full_name: Varberg, Joseph
last_name: Varberg
- first_name: Eric
full_name: Ross, Eric
last_name: Ross
- first_name: Fengyan
full_name: Deng, Fengyan
last_name: Deng
- first_name: Kexi
full_name: Yi, Kexi
last_name: Yi
- first_name: Alejandro
full_name: Sánchez Alvarado, Alejandro
last_name: Sánchez Alvarado
citation:
ama: Sasidharan V, Ancellotti L, Doddihal V, et al. Extracellular vesicles mediate
stem cell signaling and systemic RNAi in planarians. Science Advances.
2026;12(6). doi:10.1126/sciadv.ady1461
apa: Sasidharan, V., Ancellotti, L., Doddihal, V., Brewster, C., Mann, F., McKinney,
M. C., … Sánchez Alvarado, A. (2026). Extracellular vesicles mediate stem cell
signaling and systemic RNAi in planarians. Science Advances. American Association
for the Advancement of Science. https://doi.org/10.1126/sciadv.ady1461
chicago: Sasidharan, Vidyanand, Laura Ancellotti, Viraj Doddihal, Carolyn Brewster,
Frederick Mann, Mary Cathleen McKinney, Joseph Varberg, et al. “Extracellular
Vesicles Mediate Stem Cell Signaling and Systemic RNAi in Planarians.” Science
Advances. American Association for the Advancement of Science, 2026. https://doi.org/10.1126/sciadv.ady1461.
ieee: V. Sasidharan et al., “Extracellular vesicles mediate stem cell signaling
and systemic RNAi in planarians,” Science Advances, vol. 12, no. 6. American
Association for the Advancement of Science, 2026.
ista: Sasidharan V, Ancellotti L, Doddihal V, Brewster C, Mann F, McKinney MC, Varberg
J, Ross E, Deng F, Yi K, Sánchez Alvarado A. 2026. Extracellular vesicles mediate
stem cell signaling and systemic RNAi in planarians. Science Advances. 12(6),
eady1461.
mla: Sasidharan, Vidyanand, et al. “Extracellular Vesicles Mediate Stem Cell Signaling
and Systemic RNAi in Planarians.” Science Advances, vol. 12, no. 6, eady1461,
American Association for the Advancement of Science, 2026, doi:10.1126/sciadv.ady1461.
short: V. Sasidharan, L. Ancellotti, V. Doddihal, C. Brewster, F. Mann, M.C. McKinney,
J. Varberg, E. Ross, F. Deng, K. Yi, A. Sánchez Alvarado, Science Advances 12
(2026).
date_created: 2026-03-02T10:08:07Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-03-02T14:23:22Z
day: '01'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1126/sciadv.ady1461
file:
- access_level: open_access
checksum: fa9f6dafe3538e2d2872c098e06d1712
content_type: application/pdf
creator: dernst
date_created: 2026-03-02T14:19:35Z
date_updated: 2026-03-02T14:19:35Z
file_id: '21389'
file_name: 2026_ScienceAdv_Sasidharan.pdf
file_size: 2841345
relation: main_file
success: 1
file_date_updated: 2026-03-02T14:19:35Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '6'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21707'
abstract:
- lang: eng
text: Structural and functional differences between brain hemispheres are a common
feature of animal nervous systems with reduced bilateral asymmetry often linked
to impaired cognitive performance. How neuronal left-right asymmetry is initiated
and integrated into a bilaterally symmetrical ground pattern is poorly understood.
Here, we show that the directional asymmetry of a Drosophila central brain circuit
originates from axonal interactions of two types of bilateral pioneer neurons.
Subsequent recruitment of neighboring neurons into the asymmetric neuropil primordium
results in hemisphere-specific microcircuits. Circuit lateralization requires
dynamic expression of the cell adhesion molecule Fasciclin 2 to maintain structural
plasticity in axonal remodeling. Reduced circuit asymmetry following cell type–specific
Fasciclin 2 manipulation affects adult brain function. These results reveal an
unexpected degree of developmental plasticity of late-born Drosophila neurons
in the formation of a circuit node via the lateralized recruitment of symmetric
circuit components.
acknowledgement: "We thank I. Salecker (Flybow), B. Altenhein (Fas2-Gal4Mz507), A.
Nose (UAS-intra- and extra-Fas2::YFP), and C. S. Goodman (UAS-Fas2PEST+/−), as well
as the Bloomington Stock Center for providing materials and fly stocks. We thank
S. Waddell and the lab, especially B. Senapati, for providing the opportunity to
conduct memory experiments at the CNCB, University of Oxford, and for supervision
and discussions during this period. We also thank W. Kallina, S. Ilgerl, D. Bartel,
A. Grimm, and A. Litin for technical support and the Hummel Lab for stimulating
discussions and critical comments on the manuscript. We acknowledge the early exploratory
work of A. Mattia, S. Trkulja, C. Schönherr, S. Bogner, B. Simpson, L. Tomasek,
H. Roth, H. Vokač, R. Gredler, F. Kapelari, T. Kolarova, C. Ignitsch, Á. Bautista-Soldevila,
and M. Kassem.\r\nThis research was funded by the University of Vienna, the Vienna
Doctoral School Cognition, Behaviour and Neuroscience (uni:docs fellowship) (to
J.W.M.) and by the Austrian Science Fund (FWF) (Cluster of Excellence Neuronal Circuits
in Health and Disease, grant DOI 10.55776/COE16; https://www.fwf.ac.at/en/research-radar/10.55776/COE16)
(to T.H.). For open access purposes, the author has applied a CC BY public copyright
license to any author-accepted manuscript version arising from this submission."
article_number: eaea6020
article_processing_charge: Yes
article_type: original
author:
- first_name: Johann W.
full_name: Markovitsch, Johann W.
last_name: Markovitsch
- first_name: Daniel
full_name: Mitić, Daniel
last_name: Mitić
- first_name: Alisa
full_name: Del Pilar Jiménez García, Alisa
last_name: Del Pilar Jiménez García
- first_name: Alsberga
full_name: Zane, Alsberga
id: 60f7509a-f652-11ea-9d86-b963d6490d7c
last_name: Zane
orcid: 0009-0003-0415-7603
- first_name: Sarah
full_name: Kainz, Sarah
last_name: Kainz
- first_name: Rashmit
full_name: Kaur, Rashmit
last_name: Kaur
- first_name: Thomas
full_name: Hummel, Thomas
last_name: Hummel
citation:
ama: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, et al. Sequential formation
of Drosophila circuit asymmetry via prolonged structural plasticity. Science
Advances. 2026;12(13). doi:10.1126/sciadv.aea6020
apa: Markovitsch, J. W., Mitić, D., Del Pilar Jiménez García, A., Zane, A., Kainz,
S., Kaur, R., & Hummel, T. (2026). Sequential formation of Drosophila circuit
asymmetry via prolonged structural plasticity. Science Advances. American
Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aea6020
chicago: Markovitsch, Johann W., Daniel Mitić, Alisa Del Pilar Jiménez García, Alsberga
Zane, Sarah Kainz, Rashmit Kaur, and Thomas Hummel. “Sequential Formation of Drosophila
Circuit Asymmetry via Prolonged Structural Plasticity.” Science Advances.
American Association for the Advancement of Science, 2026. https://doi.org/10.1126/sciadv.aea6020.
ieee: J. W. Markovitsch et al., “Sequential formation of Drosophila circuit
asymmetry via prolonged structural plasticity,” Science Advances, vol.
12, no. 13. American Association for the Advancement of Science, 2026.
ista: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, Zane A, Kainz S, Kaur
R, Hummel T. 2026. Sequential formation of Drosophila circuit asymmetry via prolonged
structural plasticity. Science Advances. 12(13), eaea6020.
mla: Markovitsch, Johann W., et al. “Sequential Formation of Drosophila Circuit
Asymmetry via Prolonged Structural Plasticity.” Science Advances, vol.
12, no. 13, eaea6020, American Association for the Advancement of Science, 2026,
doi:10.1126/sciadv.aea6020.
short: J.W. Markovitsch, D. Mitić, A. Del Pilar Jiménez García, A. Zane, S. Kainz,
R. Kaur, T. Hummel, Science Advances 12 (2026).
date_created: 2026-04-12T22:01:48Z
date_published: 2026-03-27T00:00:00Z
date_updated: 2026-05-04T09:18:06Z
day: '27'
ddc:
- '570'
department:
- _id: MiSi
- _id: GradSch
doi: 10.1126/sciadv.aea6020
file:
- access_level: open_access
checksum: 3eed470fe73e53d2a8d55d6fba6934e3
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T09:16:36Z
date_updated: 2026-05-04T09:16:36Z
file_id: '21786'
file_name: 2026_ScienceAdv_Markovitsch.pdf
file_size: 11101140
relation: main_file
success: 1
file_date_updated: 2026-05-04T09:16:36Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '13'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sequential formation of Drosophila circuit asymmetry via prolonged structural
plasticity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21750'
abstract:
- lang: eng
text: Liquid-like superionic conductors, with highly mobile ions in a rigid framework,
offer intrinsically low lattice thermal conductivity without compromising electronic
transport. Argyrodite-type Ag8SnSe6 exhibits a melt-like Ag sublattice that drives
lattice thermal conductivity (κL) below 0.2 watts per meter per kelvin, yet its
low carrier concentration limits the power factor. Here, interstitial Ag atoms
raise the Fermi level into the conduction band, substantially increasing the electron
concentration. Simultaneously, the formation of a secondary Ag2Se phase generates
lattice distortions that enhance phonon scattering. A pronounced mismatch between
electronic (~200 nanometers) and phononic (~0.22 nanometers) mean free paths decouples
charge and heat transport, enabling concurrent suppression of κL and retention
of high electrical conductivity. This coupled electronic-phononic modulation yields
a record ZT of 0.72 at ambient temperature and a peak ZT of 1.1 at 735 kelvins,
with an average ZTavg of 0.72 over 320 to 735 kelvins. A unicouple device achieves
6.3% efficiency under a 357-kelvin gradient, highlighting a practical strategy
for high-performance midtemperature thermoelectrics.
acknowledged_ssus:
- _id: LifeSc
acknowledgement: The Scientific Service Units (SSU) of ISTA supported this research
through resources provided by the Lab Support Facility (LSF). This work was supported
by the National Key R&D Program of China grant 2024YFE0105200 (to C.S.), National
Natural Science Foundation of China grant 12504038 (to M.L.), China Postdoctoral
Science Foundation grant 2023M743151 (to M.L.), Natural Science Foundation of Henan
Province grant 252300421763 (to M.L.), Key Scientific Research Project of Higher
Education Institutions in Henan Province grant 25A140004 (to M.L.), National Natural
Science Foundation of China grant 12204156 (to D.W.), China Postdoctoral Science
Foundation grant 2023TQ0315 and 2023 M743224 (to D.W.), Generalitat de Catalunya
grant 2021SGR00457 (to J.A.), and European Regional Development Fund grants ENE2016-77798-C4-3-R,
PID2020-116093RB-C43, and AEI/10.13039/501100011033 (to A.C.). This work also was
financially supported by ISTA and the Werner Siemens Foundation (to M.I.).
article_number: eaec9073
article_processing_charge: Yes
article_type: original
author:
- first_name: Mengyao
full_name: Li, Mengyao
last_name: Li
- first_name: Xueke
full_name: Zhao, Xueke
last_name: Zhao
- first_name: Yu
full_name: Zhang, Yu
last_name: Zhang
- first_name: Jing
full_name: Yu, Jing
last_name: Yu
- first_name: Xuyang
full_name: Liu, Xuyang
last_name: Liu
- first_name: Mochen
full_name: Jia, Mochen
last_name: Jia
- first_name: Hongzhang
full_name: Song, Hongzhang
last_name: Song
- first_name: Dongyang
full_name: Wang, Dongyang
last_name: Wang
- first_name: Jordi
full_name: Arbiol, Jordi
last_name: Arbiol
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
- first_name: Chongxin
full_name: Shan, Chongxin
last_name: Shan
- first_name: Andreu
full_name: Cabot, Andreu
last_name: Cabot
- first_name: Ziyu
full_name: Wang, Ziyu
last_name: Wang
citation:
ama: Li M, Zhao X, Zhang Y, et al. Electronic-phononic decoupling and Fermi-level
tuning enable high thermoelectric performance in Ag8SnSe6. Science Advances.
2026;12(15). doi:10.1126/sciadv.aec9073
apa: Li, M., Zhao, X., Zhang, Y., Yu, J., Liu, X., Jia, M., … Wang, Z. (2026). Electronic-phononic
decoupling and Fermi-level tuning enable high thermoelectric performance in Ag8SnSe6.
Science Advances. AAAS. https://doi.org/10.1126/sciadv.aec9073
chicago: Li, Mengyao, Xueke Zhao, Yu Zhang, Jing Yu, Xuyang Liu, Mochen Jia, Hongzhang
Song, et al. “Electronic-Phononic Decoupling and Fermi-Level Tuning Enable High
Thermoelectric Performance in Ag8SnSe6.” Science Advances. AAAS, 2026.
https://doi.org/10.1126/sciadv.aec9073.
ieee: M. Li et al., “Electronic-phononic decoupling and Fermi-level tuning
enable high thermoelectric performance in Ag8SnSe6,” Science Advances,
vol. 12, no. 15. AAAS, 2026.
ista: Li M, Zhao X, Zhang Y, Yu J, Liu X, Jia M, Song H, Wang D, Arbiol J, Ibáñez
M, Shan C, Cabot A, Wang Z. 2026. Electronic-phononic decoupling and Fermi-level
tuning enable high thermoelectric performance in Ag8SnSe6. Science Advances. 12(15),
eaec9073.
mla: Li, Mengyao, et al. “Electronic-Phononic Decoupling and Fermi-Level Tuning
Enable High Thermoelectric Performance in Ag8SnSe6.” Science Advances,
vol. 12, no. 15, eaec9073, AAAS, 2026, doi:10.1126/sciadv.aec9073.
short: M. Li, X. Zhao, Y. Zhang, J. Yu, X. Liu, M. Jia, H. Song, D. Wang, J. Arbiol,
M. Ibáñez, C. Shan, A. Cabot, Z. Wang, Science Advances 12 (2026).
date_created: 2026-04-19T22:07:47Z
date_published: 2026-04-10T00:00:00Z
date_updated: 2026-05-06T06:08:27Z
day: '10'
ddc:
- '530'
department:
- _id: MaIb
doi: 10.1126/sciadv.aec9073
external_id:
pmid:
- '41961944'
file:
- access_level: open_access
checksum: 9bd4546a23f218972f83164fb21003e1
content_type: application/pdf
creator: dernst
date_created: 2026-05-06T06:06:26Z
date_updated: 2026-05-06T06:06:26Z
file_id: '21802'
file_name: 2026_ScienceAdv_Li.pdf
file_size: 3727993
relation: main_file
success: 1
file_date_updated: 2026-05-06T06:06:26Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '15'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
Semiconductors for Waste Heat Recovery'
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electronic-phononic decoupling and Fermi-level tuning enable high thermoelectric
performance in Ag8SnSe6
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21914'
abstract:
- lang: eng
text: 'Cyclic adenosine monophosphate (cAMP) is a fundamental second messenger involved
in diverse signaling pathways across both animals and plants. While the role of
3′,5′-cAMP has been extensively characterized, the biological significance of
its structural isomer, 2′,3′-cAMP, remains largely unexplored, particularly in
plants. Here, we show that 2′,3′-cAMP and 3′,5′-cAMP represent parallel signaling
systems in Arabidopsis thaliana, with different enzymatic origins and largely
distinct downstream effects. In vitro enzymatic assays show that plant adenylate
cyclases (ACs), including AFB5 and HpAC1, produce specifically 3′,5′-cAMP from
ATP, whereas the TIR domain of protein L7 also catalyzes the formation of 2′,3′-cAMP
from RNA. Comprehensive multiomics analyses reveal that two isomers elicit distinct
yet partially overlapping metabolic, proteomic, and transcriptional response:
2′,3′-cAMP activates broad, stress-adaptive gene expression reprogramming, while
3′,5′-cAMP fine-tunes responses related to nutrient status and cellular homeostasis.
Our findings establish the existence of dual cAMP signaling systems in plants,
each with specialized functions and provide insights into the complex regulatory
networks governing plant physiology.'
acknowledged_ssus:
- _id: MassSpec
- _id: LifeSc
acknowledgement: " We thank J. Chai and D. Yu for providing the MBP-fused L7TIR plasmid
and K. Jaworski (Nicolaus Copernicus University) for the GST-HpAC1 plasmid. We
also thank M. Randuch and L. Fiedler for providing vectors for recombinant AFB5
and ADCY. We are also grateful to E. Dutkiewicz, L. Trübestein, N. Krasnici and
A. Michaelis for excellent technical\r\nassistance. We acknowledge the support of
the LSF Mass Spectrometry Service and the Lab\r\nSupport Facility at the Institute
of Science and Technology Austria for their contributions,\r\nincluding consultation
on size exclusion chromatography, LC/MS experimental design,\r\nmetabolomics sample
preparation, LC/MS method optimization, data acquisition, raw data\r\nanalysis,
and absolute quantification. This project is supported by the European\r\nResearch
Council (ERC) under the European Union’s Horizon 2020 research and innovation\r\nprogram
(101142681 CYNIPS) and Austrian Science Fund (FWF; P 37051-B), both to J.Friml.\r\nWe
acknowledge the generous support of the Taif University Researchers Supporting\r\nProject:
TURSP-HC2022/02 and Max-Planck-Society to A.S. "
article_number: aea7828
article_processing_charge: Yes
article_type: original
author:
- first_name: Mingyue
full_name: Li, Mingyue
id: 01f96916-0235-11eb-9379-a323192643b7
last_name: Li
- first_name: Monika
full_name: Chodasiewicz, Monika
last_name: Chodasiewicz
- first_name: Malavika
full_name: Muraleedharan, Malavika
last_name: Muraleedharan
- first_name: Israel M.
full_name: Lopez, Israel M.
last_name: Lopez
- first_name: Michal
full_name: Gorka, Michal
last_name: Gorka
- first_name: Olga
full_name: Kerber, Olga
last_name: Kerber
- first_name: Saqer S.
full_name: Alotaibi, Saqer S.
last_name: Alotaibi
- first_name: Andrew D.L.
full_name: Nelson, Andrew D.L.
last_name: Nelson
- first_name: Rene
full_name: Lenobel, Rene
last_name: Lenobel
- first_name: Jaroslava
full_name: Friedecká, Jaroslava
last_name: Friedecká
- first_name: Aleksandra
full_name: Skirycz, Aleksandra
last_name: Skirycz
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li M, Chodasiewicz M, Muraleedharan M, et al. Biogenesis and downstream effects
of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances. 2026;12(19).
doi:10.1126/sciadv.aea7828
apa: Li, M., Chodasiewicz, M., Muraleedharan, M., Lopez, I. M., Gorka, M., Kerber,
O., … Friml, J. (2026). Biogenesis and downstream effects of 3’,5’ and 2’,3’ cAMP
isomers in plants. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aea7828
chicago: Li, Mingyue, Monika Chodasiewicz, Malavika Muraleedharan, Israel M. Lopez,
Michal Gorka, Olga Kerber, Saqer S. Alotaibi, et al. “Biogenesis and Downstream
Effects of 3’,5’ and 2’,3’ CAMP Isomers in Plants.” Science Advances. AAAS,
2026. https://doi.org/10.1126/sciadv.aea7828.
ieee: M. Li et al., “Biogenesis and downstream effects of 3’,5’ and 2’,3’
cAMP isomers in plants,” Science Advances, vol. 12, no. 19. AAAS, 2026.
ista: Li M, Chodasiewicz M, Muraleedharan M, Lopez IM, Gorka M, Kerber O, Alotaibi
SS, Nelson ADL, Lenobel R, Friedecká J, Skirycz A, Friml J. 2026. Biogenesis and
downstream effects of 3’,5’ and 2’,3’ cAMP isomers in plants. Science Advances.
12(19), aea7828.
mla: Li, Mingyue, et al. “Biogenesis and Downstream Effects of 3’,5’ and 2’,3’ CAMP
Isomers in Plants.” Science Advances, vol. 12, no. 19, aea7828, AAAS, 2026,
doi:10.1126/sciadv.aea7828.
short: M. Li, M. Chodasiewicz, M. Muraleedharan, I.M. Lopez, M. Gorka, O. Kerber,
S.S. Alotaibi, A.D.L. Nelson, R. Lenobel, J. Friedecká, A. Skirycz, J. Friml,
Science Advances 12 (2026).
corr_author: '1'
date_created: 2026-05-24T22:01:31Z
date_published: 2026-05-08T00:00:00Z
date_updated: 2026-06-02T14:36:41Z
day: '08'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1126/sciadv.aea7828
external_id:
pmid:
- '42102187'
file:
- access_level: open_access
checksum: 75b8ef2db078652c750e34e9cd98a808
content_type: application/pdf
creator: dernst
date_created: 2026-06-02T14:33:55Z
date_updated: 2026-06-02T14:33:55Z
file_id: '21941'
file_name: 2026_ScienceAdv_Li2.pdf
file_size: 2014452
relation: main_file
success: 1
file_date_updated: 2026-06-02T14:33:55Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '19'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6
grant_number: P37051
name: Guanylate cyclase activity of TIR1/AFBs auxin receptors
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Biogenesis and downstream effects of 3',5' and 2',3' cAMP isomers in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '20220'
abstract:
- lang: eng
text: Stress granules (SG) are biomolecular condensates that represent an adaptive
response of cells to various stresses, including heat. However, the cell type–specific
function and relevance of SG formation, especially during reproductive development,
are largely not understood. Here, we show that the meiotic A-type cyclin TARDY
ASYNCHRONOUS MEIOSIS (TAM) is recruited to SGs in male meiocytes of Arabidopsis
after exposure to heat. We find that the amino terminus of TAM is necessary and
sufficient for the localization of proteins to meiotic SGs. Swapping the amino
terminus of TAM with the one of its sister protein CYCA1;1 resulted in a separation-of-function
allele of TAM, which prevents the partitioning of TAM to SGs while restoring a
wild-type phenotype in a tam mutant background under nonheat stress conditions.
Notably, plants expressing this TAM version prematurely terminate meiosis under
heat resulting in unreduced gametes. Thus, the formation of TAM-containing SGs
is necessary for genome stability under heat stress.
acknowledged_ssus:
- _id: Bio
acknowledgement: "We thank L. Strader (Duke University, Durham) and A. Holehouse (Washington
University, Saint Louis) for discussion and input in LLPS. We thank T. Nakagawa
(Shimane University, Matsue) for providing the pGWB604 Gateway vector containing
bar gene identified by Meiji Seika Kaisha Ltd. We thank M. Heese (Hamburg University)
for the critical reading and comments on this manuscript. We further thank J. Mehrmann
(Hamburg University) for technical assistance. We thank the ISTA imaging facility
for assistance for microscopy.\r\nThis project has received funding from JST-PRESTO
(JPMJPR18H7), JST-CREST (JPMJCR18H4), European Union’s Horizon 2020 under MSCA grant
101034413, and a federal grant from the state of Hamburg (LFF-BiCon)."
article_processing_charge: Yes
article_type: original
author:
- first_name: Joke G
full_name: De Jaeger-Braet, Joke G
id: 26bd38d3-c59a-11ee-a1af-d7a988cafcc5
last_name: De Jaeger-Braet
- first_name: Merle
full_name: Hartmann, Merle
last_name: Hartmann
- first_name: Lev
full_name: Böttger, Lev
last_name: Böttger
- first_name: Chao
full_name: Yang, Chao
id: 082e3e6e-8069-11ed-8390-c8cce7b1aaca
last_name: Yang
- first_name: Takahiro
full_name: Hamada, Takahiro
last_name: Hamada
- first_name: Stefan
full_name: Hoth, Stefan
last_name: Hoth
- first_name: Xiaoqi
full_name: Feng, Xiaoqi
id: e0164712-22ee-11ed-b12a-d80fcdf35958
last_name: Feng
orcid: 0000-0002-4008-1234
- first_name: Magdalena
full_name: Weingartner, Magdalena
last_name: Weingartner
- first_name: Arp
full_name: Schnittger, Arp
last_name: Schnittger
citation:
ama: De Jaeger-Braet JG, Hartmann M, Böttger L, et al. The recruitment of the A-type
cyclin TAM to stress granules is crucial for meiotic fidelity under heat. Science
Advances. 2025;11(32):eadr5694. doi:10.1126/sciadv.adr5694
apa: De Jaeger-Braet, J. G., Hartmann, M., Böttger, L., Yang, C., Hamada, T., Hoth,
S., … Schnittger, A. (2025). The recruitment of the A-type cyclin TAM to stress
granules is crucial for meiotic fidelity under heat. Science Advances.
AAAS. https://doi.org/10.1126/sciadv.adr5694
chicago: De Jaeger-Braet, Joke G, Merle Hartmann, Lev Böttger, Chao Yang, Takahiro
Hamada, Stefan Hoth, Xiaoqi Feng, Magdalena Weingartner, and Arp Schnittger. “The
Recruitment of the A-Type Cyclin TAM to Stress Granules Is Crucial for Meiotic
Fidelity under Heat.” Science Advances. AAAS, 2025. https://doi.org/10.1126/sciadv.adr5694.
ieee: J. G. De Jaeger-Braet et al., “The recruitment of the A-type cyclin
TAM to stress granules is crucial for meiotic fidelity under heat,” Science
Advances, vol. 11, no. 32. AAAS, p. eadr5694, 2025.
ista: De Jaeger-Braet JG, Hartmann M, Böttger L, Yang C, Hamada T, Hoth S, Feng
X, Weingartner M, Schnittger A. 2025. The recruitment of the A-type cyclin TAM
to stress granules is crucial for meiotic fidelity under heat. Science Advances.
11(32), eadr5694.
mla: De Jaeger-Braet, Joke G., et al. “The Recruitment of the A-Type Cyclin TAM
to Stress Granules Is Crucial for Meiotic Fidelity under Heat.” Science Advances,
vol. 11, no. 32, AAAS, 2025, p. eadr5694, doi:10.1126/sciadv.adr5694.
short: J.G. De Jaeger-Braet, M. Hartmann, L. Böttger, C. Yang, T. Hamada, S. Hoth,
X. Feng, M. Weingartner, A. Schnittger, Science Advances 11 (2025) eadr5694.
date_created: 2025-08-24T22:01:30Z
date_published: 2025-08-08T00:00:00Z
date_updated: 2025-09-30T14:24:10Z
day: '08'
ddc:
- '580'
department:
- _id: XiFe
doi: 10.1126/sciadv.adr5694
ec_funded: 1
external_id:
isi:
- '001549102600016'
file:
- access_level: open_access
checksum: 0f1ae246acc9b075f01bf4afe382c8ba
content_type: application/pdf
creator: dernst
date_created: 2025-09-02T07:05:37Z
date_updated: 2025-09-02T07:05:37Z
file_id: '20270'
file_name: 2025_ScienceAdvance_DeJaegerBraet.pdf
file_size: 10876817
relation: main_file
success: 1
file_date_updated: 2025-09-02T07:05:37Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '32'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: eadr5694
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: The recruitment of the A-type cyclin TAM to stress granules is crucial for
meiotic fidelity under heat
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '20351'
abstract:
- lang: eng
text: Rab GTPases organize intracellular trafficking and provide identity to organelles.
Their spatiotemporal activation by guanine nucleotide exchange factors (GEFs)
is tightly controlled to ensure fidelity. Our structural and functional comparison
of the tri-longin domain RabGEFs Mon1-Ccz1 and Fuzzy-Inturned reveals the molecular
basis for their target specificity. Both complexes rely on a conserved sequence
motif of their substrate GTPases for the catalytic mechanism, while secondary
interactions allow discrimination between targets. We also find that dimeric Mon1-Ccz1
from fungi and the metazoan homologs with the additional third subunit RMC1/Bulli
bind membranes through electrostatic interactions via distinct interfaces. Protein-lipid
interaction studies and functional characterization in flies reveal an essential
function of RMC1/Bulli as mediator of GEF complex membrane recruitment. In the
case of Fuzzy-Inturned, reconstitution experiments demonstrate that the BAR (Bin-Amphiphysin-Rvs)
domain protein CiBAR1 can support membrane recruitment of the GEF. Collectively,
our study demonstrates the molecular basis for the adaptation of TLD-RabGEFs to
different cellular functions.
acknowledgement: 'We thank A.-M. Lawrence-Dörner and B. Berkenfeld for technical assistance
and the members of the Kümmel Lab for constructive feedback. We are grateful to
C. Ungermann and L. Langemeyer for insightful discussions and to F. Barr for providing
plasmids encoding Fuzzy, Inturned, Rab23, and Rsg1. The template clone Flag-ciBAR1
was a gift from K.-I. Takemaru (Addgene, plasmid #200440). We thank the Bloomington
Drosophila Stock center (BDSC) and DSHB for providing fly stocks and antibodies.
This work was supported by the German Research Foundation (DFG) through the grants
SFB1557-P10 (D.K.), SFB1557-P11 (A.M.), and SFB1577-P6, PA517/12-2, PA517/14-1,
PA517/15-1, and PA517/16-1 (A.P.). Cryo-EM data were collected at the infrastructure
of the University of Osnabrück, funded by the DFG (project number 455249646). J.-H.S.
was supported by the Friedrich-Ebert Foundation. M.L. acknowledges funding from
the European Research Council (ERC) under the European Union’s Horizon 2020 research
and innovation program (grant agreement number 101045340).'
article_processing_charge: Yes
article_type: original
author:
- first_name: Stephan
full_name: Wilmes, Stephan
last_name: Wilmes
- first_name: Jesse
full_name: Tönjes, Jesse
last_name: Tönjes
- first_name: Maik
full_name: Drechsler, Maik
last_name: Drechsler
- first_name: Anita
full_name: Ruf, Anita
last_name: Ruf
- first_name: Jan Hannes
full_name: Schäfer, Jan Hannes
last_name: Schäfer
- first_name: Anna
full_name: Lürick, Anna
last_name: Lürick
- first_name: Dovile
full_name: Januliene, Dovile
last_name: Januliene
- first_name: Steven
full_name: Apelt, Steven
last_name: Apelt
- first_name: Daniele
full_name: Di Iorio, Daniele
last_name: Di Iorio
- first_name: Seraphine V.
full_name: Wegner, Seraphine V.
last_name: Wegner
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Arne
full_name: Moeller, Arne
last_name: Moeller
- first_name: Achim
full_name: Paululat, Achim
last_name: Paululat
- first_name: Daniel
full_name: Kümmel, Daniel
last_name: Kümmel
citation:
ama: Wilmes S, Tönjes J, Drechsler M, et al. Mechanistic adaptation of the metazoan
RabGEFs Mon1-Ccz1 and Fuzzy-Inturned. Science Advances. 2025;11(35):eadx2893.
doi:10.1126/sciadv.adx2893
apa: Wilmes, S., Tönjes, J., Drechsler, M., Ruf, A., Schäfer, J. H., Lürick, A.,
… Kümmel, D. (2025). Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1
and Fuzzy-Inturned. Science Advances. AAAS. https://doi.org/10.1126/sciadv.adx2893
chicago: Wilmes, Stephan, Jesse Tönjes, Maik Drechsler, Anita Ruf, Jan Hannes Schäfer,
Anna Lürick, Dovile Januliene, et al. “Mechanistic Adaptation of the Metazoan
RabGEFs Mon1-Ccz1 and Fuzzy-Inturned.” Science Advances. AAAS, 2025. https://doi.org/10.1126/sciadv.adx2893.
ieee: S. Wilmes et al., “Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1
and Fuzzy-Inturned,” Science Advances, vol. 11, no. 35. AAAS, p. eadx2893,
2025.
ista: Wilmes S, Tönjes J, Drechsler M, Ruf A, Schäfer JH, Lürick A, Januliene D,
Apelt S, Di Iorio D, Wegner SV, Loose M, Moeller A, Paululat A, Kümmel D. 2025.
Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned. Science
Advances. 11(35), eadx2893.
mla: Wilmes, Stephan, et al. “Mechanistic Adaptation of the Metazoan RabGEFs Mon1-Ccz1
and Fuzzy-Inturned.” Science Advances, vol. 11, no. 35, AAAS, 2025, p.
eadx2893, doi:10.1126/sciadv.adx2893.
short: S. Wilmes, J. Tönjes, M. Drechsler, A. Ruf, J.H. Schäfer, A. Lürick, D. Januliene,
S. Apelt, D. Di Iorio, S.V. Wegner, M. Loose, A. Moeller, A. Paululat, D. Kümmel,
Science Advances 11 (2025) eadx2893.
date_created: 2025-09-14T22:01:32Z
date_published: 2025-08-29T00:00:00Z
date_updated: 2025-09-30T14:40:27Z
day: '29'
ddc:
- '570'
department:
- _id: MaLo
doi: 10.1126/sciadv.adx2893
external_id:
isi:
- '001559806100033'
pmid:
- '40864718'
file:
- access_level: open_access
checksum: a3de801f3c6c1deadd7099d965db799a
content_type: application/pdf
creator: dernst
date_created: 2025-09-15T07:23:12Z
date_updated: 2025-09-15T07:23:12Z
file_id: '20355'
file_name: 2025_ScienceAdvance_Wilmes.pdf
file_size: 3434827
relation: main_file
success: 1
file_date_updated: 2025-09-15T07:23:12Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '35'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: eadx2893
pmid: 1
project:
- _id: bd6ae2ca-d553-11ed-ba76-a4aa239da5ee
grant_number: '101045340'
name: Synthetic and structural biology of Rab GTPase networks
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanistic adaptation of the metazoan RabGEFs Mon1-Ccz1 and Fuzzy-Inturned
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19277'
abstract:
- lang: eng
text: Light-driven molecular rotary motors perform chirality-controlled unidirectional
rotations fueled by light and heat. This unique function renders them appealing
for the construction of dynamic molecular systems, actuating materials, and molecular
machines. Achieving a combination of high photoefficiency, visible-light responsiveness,
synthetic accessibility, and easy tuning of dynamic properties within a single
scaffold is critical for these applications but remains a longstanding challenge.
Herein, a series of highly photoefficient visible-light–responsive molecular motors
(MMs), featuring various rotary speeds, was obtained by a convenient one-step
formylation of their parent motors. This strategy greatly improves all aspects
of the performance of MMs—red-shifted wavelengths of excitation, high photoisomerization
quantum yields, and high photostationary state distributions of isomers—beyond
the state-of-the-art light-responsive MM systems. The development of this late-stage
functionalization strategy of MMs opens avenues for the construction of high-performance
molecular machines and devices for applications in materials science and biological
systems, representing a major advance in the synthetic toolbox of molecular machines.
acknowledgement: 'R. Sneep is acknowledged for mass spectral analysis and SFC training.
We thank A. S. Lubbe from University of Groningen for help with this manuscript
and for fruitful discussions. We thank P. Cieciórski from University of Warsaw for
help with the figure preparation. This work was supported from the following sources:
China Scholarship Council, CSC PhD Fellowship no. 201808330459 to J.S.; the Netherlands
Organization for Scientific Research (NWO-CW) (B.L.F); the Dutch Ministry of Education,
Culture, and Science (Gravitation program no. 024.001.035) (B.L.F.); Polish National
Agency for Academic Exchange (reg. no.: BPN/PPO/2023/1/00014); and National Science
Center Poland (reg. no.: 2024/03/1/ST5/00003) (W.D.).'
article_number: eadr9326
article_processing_charge: Yes
article_type: original
author:
- first_name: Jinyu
full_name: Sheng, Jinyu
id: 639f0526-27c9-11ee-95a6-966cd7f102d8
last_name: Sheng
- first_name: Carlijn L.F.
full_name: Van Beek, Carlijn L.F.
last_name: Van Beek
- first_name: Charlotte N.
full_name: Stindt, Charlotte N.
last_name: Stindt
- first_name: Wojciech
full_name: Danowski, Wojciech
last_name: Danowski
- first_name: Joanna
full_name: Jankowska, Joanna
last_name: Jankowska
- first_name: Stefano
full_name: Crespi, Stefano
last_name: Crespi
- first_name: Daisy R.S.
full_name: Pooler, Daisy R.S.
last_name: Pooler
- first_name: Michiel F.
full_name: Hilbers, Michiel F.
last_name: Hilbers
- first_name: Wybren Jan
full_name: Buma, Wybren Jan
last_name: Buma
- first_name: Ben L.
full_name: Feringa, Ben L.
last_name: Feringa
citation:
ama: Sheng J, Van Beek CLF, Stindt CN, et al. General strategy for boosting the
performance of speed-tunable rotary molecular motors with visible light. Science
Advances. 2025;11(8). doi:10.1126/sciadv.adr9326
apa: Sheng, J., Van Beek, C. L. F., Stindt, C. N., Danowski, W., Jankowska, J.,
Crespi, S., … Feringa, B. L. (2025). General strategy for boosting the performance
of speed-tunable rotary molecular motors with visible light. Science Advances.
AAAS. https://doi.org/10.1126/sciadv.adr9326
chicago: Sheng, Jinyu, Carlijn L.F. Van Beek, Charlotte N. Stindt, Wojciech Danowski,
Joanna Jankowska, Stefano Crespi, Daisy R.S. Pooler, Michiel F. Hilbers, Wybren
Jan Buma, and Ben L. Feringa. “General Strategy for Boosting the Performance of
Speed-Tunable Rotary Molecular Motors with Visible Light.” Science Advances.
AAAS, 2025. https://doi.org/10.1126/sciadv.adr9326.
ieee: J. Sheng et al., “General strategy for boosting the performance of
speed-tunable rotary molecular motors with visible light,” Science Advances,
vol. 11, no. 8. AAAS, 2025.
ista: Sheng J, Van Beek CLF, Stindt CN, Danowski W, Jankowska J, Crespi S, Pooler
DRS, Hilbers MF, Buma WJ, Feringa BL. 2025. General strategy for boosting the
performance of speed-tunable rotary molecular motors with visible light. Science
Advances. 11(8), eadr9326.
mla: Sheng, Jinyu, et al. “General Strategy for Boosting the Performance of Speed-Tunable
Rotary Molecular Motors with Visible Light.” Science Advances, vol. 11,
no. 8, eadr9326, AAAS, 2025, doi:10.1126/sciadv.adr9326.
short: J. Sheng, C.L.F. Van Beek, C.N. Stindt, W. Danowski, J. Jankowska, S. Crespi,
D.R.S. Pooler, M.F. Hilbers, W.J. Buma, B.L. Feringa, Science Advances 11 (2025).
date_created: 2025-03-02T23:01:51Z
date_published: 2025-02-21T00:00:00Z
date_updated: 2025-09-30T10:46:23Z
day: '21'
ddc:
- '540'
department:
- _id: RaKl
doi: 10.1126/sciadv.adr9326
external_id:
isi:
- '001425511500020'
pmid:
- '39970219'
file:
- access_level: open_access
checksum: 34ad18a07cb87fdde7bdb626fdeef832
content_type: application/pdf
creator: dernst
date_created: 2025-03-04T10:57:39Z
date_updated: 2025-03-04T10:57:39Z
file_id: '19293'
file_name: 2025_ScienceAdvance_Sheng.pdf
file_size: 584613
relation: main_file
success: 1
file_date_updated: 2025-03-04T10:57:39Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '8'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: General strategy for boosting the performance of speed-tunable rotary molecular
motors with visible light
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19282'
abstract:
- lang: eng
text: Osmium complexes with osmium in different oxidation states (II, III, IV, and
VI) have been reported to exhibit antiproliferative activity in cancer cell lines.
Herein, we demonstrate unexplored opportunities offered by 187Os nuclear forward
scattering (NFS) and nuclear inelastic scattering (NIS) of synchrotron radiation
for characterization of hyperfine interactions and lattice dynamics in a benchmark
Os(VI) complex, K2[OsO2(OH)4]. We determined the isomer shift [δ = 3.3(1) millimeters
per second] relative to [OsIVCl6]2− and quadrupole splitting [ΔEQ = 12.0(2) millimeters
per second] with NFS. We estimated the Lamb-Mössbauer factor [0.80(4)], extracted
the density of phonon states, and carried out a thermodynamics characterization
using the NIS data combined with first-principles calculations. Overall, we provide
evidence that 187Os nuclear resonance scattering is a reliable technique for the
investigation of hyperfine interactions and Os-specific vibrations in osmium(VI)
species and is thus applicable for such measurements in osmium complexes of other
oxidation states, including those with anticancer activity such as Os(III) and
Os(IV).
acknowledgement: "The European Synchrotron Radiation Facility is acknowledged for
providing synchrotron radiation beamtime at the Nuclear Resonance beamlines ID18
and ID14. The technical assistance of J.-P. Celse is acknowledged during the beamtime
at the ESRF. V.B.A. and G.E.B. are thankful to Karl Mayer Stiftung (Triesen, Liechtenstein)
and Valüna Stiftung (Vaduz, Liechtenstein) for financial support in purchasing the
187Os metal. We are also thankful to A. Dobrov for help in the synthesis of 187OsO4
from 187Os. Ab initio calculations were done on the ASPIRE-2A cluster (www.nscc.sg)
under computational projects 11001278, 11003762, 51000267, and 11003763. This work
used computational resources of the supercomputer Fugaku provided by RIKEN/NSCC
through the HPCI System Research Project (project ID: hp240202). The computational
resources of the HPC-NUS are gratefully acknowledged.\r\nThis work was supported
by the Austrian Science Fund (FWF) grant I4729 (V.B.A.), King Saud University Researchers
Supporting Project no. RSP2025R266 (L.F.C. and A.A.A.-K.), and National University
of Singapore research projects A-8000709-00-00, A-8000017-00-00, and A-8001894-00-00
(Z.H. and L.U.)."
article_number: eads3406
article_processing_charge: Yes
article_type: original
author:
- first_name: Iryna
full_name: Stepanenko, Iryna
id: 2a1f3914-89ea-11ee-b4f9-b6c903344e34
last_name: Stepanenko
- first_name: Zhishuo
full_name: Huang, Zhishuo
last_name: Huang
- first_name: Liviu
full_name: Ungur, Liviu
last_name: Ungur
- first_name: Dimitrios
full_name: Bessas, Dimitrios
last_name: Bessas
- first_name: Aleksandr
full_name: Chumakov, Aleksandr
last_name: Chumakov
- first_name: Ilya
full_name: Sergueev, Ilya
last_name: Sergueev
- first_name: Gabriel E.
full_name: Büchel, Gabriel E.
last_name: Büchel
- first_name: Abdullah A.
full_name: Al-Kahtani, Abdullah A.
last_name: Al-Kahtani
- first_name: Liviu F.
full_name: Chibotaru, Liviu F.
last_name: Chibotaru
- first_name: Joshua
full_name: Telser, Joshua
last_name: Telser
- first_name: Vladimir B.
full_name: Arion, Vladimir B.
last_name: Arion
citation:
ama: Stepanenko I, Huang Z, Ungur L, et al. 187Os nuclear resonance scattering to
explore hyperfine interactions and lattice dynamics for biological applications.
Science Advances. 2025;11(6). doi:10.1126/sciadv.ads3406
apa: Stepanenko, I., Huang, Z., Ungur, L., Bessas, D., Chumakov, A., Sergueev, I.,
… Arion, V. B. (2025). 187Os nuclear resonance scattering to explore hyperfine
interactions and lattice dynamics for biological applications. Science Advances.
AAAS. https://doi.org/10.1126/sciadv.ads3406
chicago: Stepanenko, Iryna, Zhishuo Huang, Liviu Ungur, Dimitrios Bessas, Aleksandr
Chumakov, Ilya Sergueev, Gabriel E. Büchel, et al. “187Os Nuclear Resonance Scattering
to Explore Hyperfine Interactions and Lattice Dynamics for Biological Applications.”
Science Advances. AAAS, 2025. https://doi.org/10.1126/sciadv.ads3406.
ieee: I. Stepanenko et al., “187Os nuclear resonance scattering to explore
hyperfine interactions and lattice dynamics for biological applications,” Science
Advances, vol. 11, no. 6. AAAS, 2025.
ista: Stepanenko I, Huang Z, Ungur L, Bessas D, Chumakov A, Sergueev I, Büchel GE,
Al-Kahtani AA, Chibotaru LF, Telser J, Arion VB. 2025. 187Os nuclear resonance
scattering to explore hyperfine interactions and lattice dynamics for biological
applications. Science Advances. 11(6), eads3406.
mla: Stepanenko, Iryna, et al. “187Os Nuclear Resonance Scattering to Explore Hyperfine
Interactions and Lattice Dynamics for Biological Applications.” Science Advances,
vol. 11, no. 6, eads3406, AAAS, 2025, doi:10.1126/sciadv.ads3406.
short: I. Stepanenko, Z. Huang, L. Ungur, D. Bessas, A. Chumakov, I. Sergueev, G.E.
Büchel, A.A. Al-Kahtani, L.F. Chibotaru, J. Telser, V.B. Arion, Science Advances
11 (2025).
date_created: 2025-03-02T23:01:53Z
date_published: 2025-02-07T00:00:00Z
date_updated: 2026-02-23T08:05:58Z
day: '07'
ddc:
- '530'
department:
- _id: StFr
doi: 10.1126/sciadv.ads3406
external_id:
isi:
- '001416079000003'
pmid:
- '39919179'
file:
- access_level: open_access
checksum: ae8f7e9914e4d2549ed9578e58a10c3c
content_type: application/pdf
creator: dernst
date_created: 2025-03-04T09:52:02Z
date_updated: 2025-03-04T09:52:02Z
file_id: '19287'
file_name: 2025_ScienceAdvance_Stepanenko.pdf
file_size: 1385761
relation: main_file
success: 1
file_date_updated: 2025-03-04T09:52:02Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '6'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: 187Os nuclear resonance scattering to explore hyperfine interactions and lattice
dynamics for biological applications
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '19663'
abstract:
- lang: eng
text: The centrosome is a microtubule orchestrator, nucleating and anchoring microtubules
that grow radially and exert forces on cargos. At the same time, mechanical stresses
from the microenvironment and cellular shape changes compress and bend microtubules.
Yet, centrosomes are membraneless organelles, raising the question of how centrosomes
withstand mechanical forces. Here, we discover that centrosomes can deform and
even fracture. We reveal that centrosomes experience deformations during navigational
pathfinding within motile cells. Coherence of the centrosome is maintained by
Dyrk3 and cNAP1, preventing fracturing by forces. While cells can compensate for
the depletion of centriolar-based centrosomes, the fracturing of centrosomes impedes
cellular function by generating coexisting microtubule organizing centers that
compete during path navigation and thereby cause cellular entanglement in the
microenvironment. Our findings show that cells actively maintain the integrity
of the centrosome to withstand mechanical forces. These results suggest that centrosome
stability preservation is fundamental, given that almost all cells in multicellular
organisms experience forces.
acknowledgement: "We thank L. Pelkmans and D. Dormann for providing Dyrk3-EGFP plasmids;
M. Heuzé for providing a RFP-Pericentrin plasmid; T. Balla for providing a PH-Akt-GFP
plasmid; E. Snaar-Jagalska for providing a pLenti-V6.3 Ultra-Chili plasmid; T. Tang
for providing CEP120 a plasmid; D. Trono for providing pMD2.G and psSPAX2 plasmids;
M. Sixt for providing EB3-mCherry and EMTB-mCherry plasmids as well as 3T3 fibroblasts,
Lifeact-GFP Hoxb8 cells, and LX293 cells; M. Duggan for RNA isolation from migrating
DCs; M. Schuster from the Biomedical Sequencing Facility at CeMM; J. Schwarz for
providing Jurkat T cells; M. Götz for initial transcriptome analysis; M. Götz and
F. Merino for discussion and sharing reagents; F. Gärtner for discussions and support;
M. Benjamin Braun for critical reading of the manuscript; and the Core Facility
Bioimaging, the Core Facility Flow Cytometry, and the Animal Core Facility of the
Biomedical Center (BMC) for excellent support.\r\nThis work was supported by Peter
Hans Hofschneider Professorship of the Stiftung Experimentelle Biomedizin (J.R.);
German Research Foundation grant “CRC914, project A12” (J.R); German Research Foundation
grant “SPP2332, project 492014049” (J.R.); LMU Institutional Strategy LMU-Excellent
within the framework of the German Excellence Initiative (J.R.); Medical & Clinician
Scientist Program (MCSP) LMU Munich (J.K.); Deutsche Forschungsgemeinschaft (DFG;
German Research Foundation) under Germany’s Excellence Strategy – EXC2151 – 390873048
(D.B.); Deutsche Forschungsgemeinschaft (DFG; German Research Foundation) Grossgeräteantrag
457838313 and under Germany’s Excellence Strategy – EXC 2151 – 390873048 (E.K.);
Ministry of Innovation, Science and Research of North-Rhine-Westphalia (fellowship
AZ: 421-8.03.03.02-137069) (E.K.); TRA Life and Health (University of Bonn) as part
of the Excellence Strategy of the federal and state governments (E.K.); and CZI
grant DAF2020-225401 and grant (DOI https://doi.org/10.37921/120055ratwvi) from
the Chan Zuckerberg Initiative DAF (R.H.)."
article_number: eadx4047
article_processing_charge: Yes
article_type: original
author:
- first_name: Madeleine T.
full_name: Schmitt, Madeleine T.
last_name: Schmitt
- first_name: Janina
full_name: Kroll, Janina
last_name: Kroll
- first_name: Mauricio J.A.
full_name: Ruiz-Fernandez, Mauricio J.A.
last_name: Ruiz-Fernandez
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Shaunak
full_name: Ghosh, Shaunak
last_name: Ghosh
- first_name: Petra
full_name: Kameritsch, Petra
last_name: Kameritsch
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Johanna
full_name: Schmid, Johanna
last_name: Schmid
- first_name: Kasia
full_name: Stefanowski, Kasia
last_name: Stefanowski
- first_name: Andreas W.
full_name: Thomae, Andreas W.
last_name: Thomae
- first_name: Jingyuan
full_name: Cheng, Jingyuan
last_name: Cheng
- first_name: Gamze Naz
full_name: Öztan, Gamze Naz
last_name: Öztan
- first_name: Peter
full_name: Konopka, Peter
last_name: Konopka
- first_name: Germán Camargo
full_name: Ortega, Germán Camargo
last_name: Ortega
- first_name: Thomas
full_name: Penz, Thomas
last_name: Penz
- first_name: Luisa
full_name: Bach, Luisa
last_name: Bach
- first_name: Dirk
full_name: Baumjohann, Dirk
last_name: Baumjohann
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Tobias
full_name: Straub, Tobias
last_name: Straub
- first_name: Felix
full_name: Meissner, Felix
last_name: Meissner
- first_name: Eva
full_name: Kiermaier, Eva
id: 3EB04B78-F248-11E8-B48F-1D18A9856A87
last_name: Kiermaier
orcid: 0000-0001-6165-5738
- first_name: Jörg
full_name: Renkawitz, Jörg
id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
last_name: Renkawitz
orcid: 0000-0003-2856-3369
citation:
ama: Schmitt MT, Kroll J, Ruiz-Fernandez MJA, et al. Protecting centrosomes from
fracturing enables efficient cell navigation. Science Advances. 2025;11(17).
doi:10.1126/sciadv.adx4047
apa: Schmitt, M. T., Kroll, J., Ruiz-Fernandez, M. J. A., Hauschild, R., Ghosh,
S., Kameritsch, P., … Renkawitz, J. (2025). Protecting centrosomes from fracturing
enables efficient cell navigation. Science Advances. AAAS. https://doi.org/10.1126/sciadv.adx4047
chicago: Schmitt, Madeleine T., Janina Kroll, Mauricio J.A. Ruiz-Fernandez, Robert
Hauschild, Shaunak Ghosh, Petra Kameritsch, Jack Merrin, et al. “Protecting Centrosomes
from Fracturing Enables Efficient Cell Navigation.” Science Advances. AAAS,
2025. https://doi.org/10.1126/sciadv.adx4047.
ieee: M. T. Schmitt et al., “Protecting centrosomes from fracturing enables
efficient cell navigation,” Science Advances, vol. 11, no. 17. AAAS, 2025.
ista: Schmitt MT, Kroll J, Ruiz-Fernandez MJA, Hauschild R, Ghosh S, Kameritsch
P, Merrin J, Schmid J, Stefanowski K, Thomae AW, Cheng J, Öztan GN, Konopka P,
Ortega GC, Penz T, Bach L, Baumjohann D, Bock C, Straub T, Meissner F, Kiermaier
E, Renkawitz J. 2025. Protecting centrosomes from fracturing enables efficient
cell navigation. Science Advances. 11(17), eadx4047.
mla: Schmitt, Madeleine T., et al. “Protecting Centrosomes from Fracturing Enables
Efficient Cell Navigation.” Science Advances, vol. 11, no. 17, eadx4047,
AAAS, 2025, doi:10.1126/sciadv.adx4047.
short: M.T. Schmitt, J. Kroll, M.J.A. Ruiz-Fernandez, R. Hauschild, S. Ghosh, P.
Kameritsch, J. Merrin, J. Schmid, K. Stefanowski, A.W. Thomae, J. Cheng, G.N.
Öztan, P. Konopka, G.C. Ortega, T. Penz, L. Bach, D. Baumjohann, C. Bock, T. Straub,
F. Meissner, E. Kiermaier, J. Renkawitz, Science Advances 11 (2025).
date_created: 2025-05-11T22:02:38Z
date_published: 2025-04-25T00:00:00Z
date_updated: 2025-09-30T12:26:21Z
day: '25'
ddc:
- '570'
department:
- _id: Bio
- _id: NanoFab
doi: 10.1126/sciadv.adx4047
external_id:
isi:
- '001476113400016'
pmid:
- '40279414'
file:
- access_level: open_access
checksum: e8ba22922fa5b23ccfcce8865f57226c
content_type: application/pdf
creator: dernst
date_created: 2025-05-12T07:46:10Z
date_updated: 2025-05-12T07:46:10Z
file_id: '19679'
file_name: 2025_ScienceAdvance_Schmitt.pdf
file_size: 2707050
relation: main_file
success: 1
file_date_updated: 2025-05-12T07:46:10Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '17'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
grant_number: CZI01
name: Tools for automation and feedback microscopy
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: Protecting centrosomes from fracturing enables efficient cell navigation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 11
year: '2025'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '18920'
abstract:
- lang: eng
text: The globally distributed marine alga Emiliania huxleyi has cooling effect
on the Earth’s climate. The population density of E. huxleyi is restricted by
Nucleocytoviricota viruses, including E. huxleyi virus 201 (EhV-201). Despite
the impact of E. huxleyi viruses on the climate, there is limited information
about their structure and replication. Here, we show that the dsDNA genome inside
the EhV-201 virion is protected by an inner membrane, capsid, and outer membrane.
EhV-201 virions infect E. huxleyi by using fivefold vertices to bind to and fuse
the virus’ inner membrane with the cell plasma membrane. Progeny virions assemble
in the cytoplasm at the surface of endoplasmic reticulum–derived membrane segments.
Genome packaging initiates synchronously with the capsid assembly and completes
through an aperture in the forming capsid. The genome-filled capsids acquire an
outer membrane by budding into intracellular vesicles. EhV-201 infection induces
a loss of surface protective layers from E. huxleyi cells, which enables the continuous
release of virions by exocytosis.
acknowledgement: We acknowledge (i) the Cryo-Electron Microscopy and Tomography Core
Facility and Proteomics Core Facility of the Central European Institute of Technology
(CEITEC), Masaryk University, supported by the Ministry of Education, Youth, and
Sports of the Czech Republic (grant LM2018127); (ii) the Cellular Imaging Core Facility
supported by the Czech-BioImaging large RI project (LM2018129 funded by MEYS CR);
and (iii) Plant Sciences Core Facility for support with obtaining scientific data
presented here. We acknowledge support from the project National Institute of Virology
and Bacteriology (Program EXCELES, ID project no. LX22NPO5103), funded by the European
Union - Next Generation EU. This work received funding from the Czech Science Foundation
grant GX 19-259882X to P.P., from European Regional Development Fund-Project “MSCAfellow2@MUNI”
(no. CZ.02.2.69/0.0/0.0/18_070/0009846) to C.R.B., and from Brno PhD talent scholarship
funded by Brno city municipality to M.H.
article_number: 'eadk1954 '
article_processing_charge: Yes
article_type: original
author:
- first_name: Miroslav
full_name: Homola, Miroslav
last_name: Homola
- first_name: Renate Carina
full_name: Büttner, Renate Carina
id: 3b7984c9-17ff-11ed-b6fe-f943c4a5b626
last_name: Büttner
- first_name: Tibor
full_name: Füzik, Tibor
last_name: Füzik
- first_name: Pavel
full_name: Křepelka, Pavel
last_name: Křepelka
- first_name: Radka
full_name: Holbová, Radka
last_name: Holbová
- first_name: Jiří
full_name: Nováček, Jiří
last_name: Nováček
- first_name: Marten L.
full_name: Chaillet, Marten L.
last_name: Chaillet
- first_name: Jakub
full_name: Žák, Jakub
last_name: Žák
- first_name: Danyil
full_name: Grybchuk, Danyil
last_name: Grybchuk
- first_name: Friedrich
full_name: Förster, Friedrich
last_name: Förster
- first_name: William H.
full_name: Wilson, William H.
last_name: Wilson
- first_name: Declan C.
full_name: Schroeder, Declan C.
last_name: Schroeder
- first_name: Pavel
full_name: Plevka, Pavel
last_name: Plevka
citation:
ama: Homola M, Büttner RC, Füzik T, et al. Structure and replication cycle of a
virus infecting climate-modulating alga Emiliania huxleyi. Science Advances.
2024;10(15). doi:10.1126/sciadv.adk1954
apa: Homola, M., Büttner, R. C., Füzik, T., Křepelka, P., Holbová, R., Nováček,
J., … Plevka, P. (2024). Structure and replication cycle of a virus infecting
climate-modulating alga Emiliania huxleyi. Science Advances. American Association
for the Advancement of Science. https://doi.org/10.1126/sciadv.adk1954
chicago: Homola, Miroslav, Renate Carina Büttner, Tibor Füzik, Pavel Křepelka, Radka
Holbová, Jiří Nováček, Marten L. Chaillet, et al. “Structure and Replication Cycle
of a Virus Infecting Climate-Modulating Alga Emiliania Huxleyi.” Science Advances.
American Association for the Advancement of Science, 2024. https://doi.org/10.1126/sciadv.adk1954.
ieee: M. Homola et al., “Structure and replication cycle of a virus infecting
climate-modulating alga Emiliania huxleyi,” Science Advances, vol. 10,
no. 15. American Association for the Advancement of Science, 2024.
ista: Homola M, Büttner RC, Füzik T, Křepelka P, Holbová R, Nováček J, Chaillet
ML, Žák J, Grybchuk D, Förster F, Wilson WH, Schroeder DC, Plevka P. 2024. Structure
and replication cycle of a virus infecting climate-modulating alga Emiliania huxleyi.
Science Advances. 10(15), eadk1954.
mla: Homola, Miroslav, et al. “Structure and Replication Cycle of a Virus Infecting
Climate-Modulating Alga Emiliania Huxleyi.” Science Advances, vol. 10,
no. 15, eadk1954, American Association for the Advancement of Science, 2024, doi:10.1126/sciadv.adk1954.
short: M. Homola, R.C. Büttner, T. Füzik, P. Křepelka, R. Holbová, J. Nováček, M.L.
Chaillet, J. Žák, D. Grybchuk, F. Förster, W.H. Wilson, D.C. Schroeder, P. Plevka,
Science Advances 10 (2024).
date_created: 2025-01-27T14:32:34Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2025-05-14T09:29:04Z
day: '01'
ddc:
- '570'
department:
- _id: EM-Fac
doi: 10.1126/sciadv.adk1954
external_id:
pmid:
- '38598627'
file:
- access_level: open_access
checksum: 291dd7ceccbe6bfd8e0a9157584f88e9
content_type: application/pdf
creator: dernst
date_created: 2025-01-27T14:40:08Z
date_updated: 2025-01-27T14:40:08Z
file_id: '18921'
file_name: 2024_ScienceAdv_Homola.pdf
file_size: 40623405
relation: main_file
success: 1
file_date_updated: 2025-01-27T14:40:08Z
has_accepted_license: '1'
intvolume: ' 10'
issue: '15'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
link:
- relation: software
url: ' https://github.com/fuzikt/tomostarpy.'
scopus_import: '1'
status: public
title: Structure and replication cycle of a virus infecting climate-modulating alga
Emiliania huxleyi
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '15047'
abstract:
- lang: eng
text: Tropical precipitation extremes and their changes with surface warming are
investigated using global storm resolving simulations and high-resolution observations.
The simulations demonstrate that the mesoscale organization of convection, a process
that cannot be physically represented by conventional global climate models, is
important for the variations of tropical daily accumulated precipitation extremes.
In both the simulations and observations, daily precipitation extremes increase
in a more organized state, in association with larger, but less frequent, storms.
Repeating the simulations for a warmer climate results in a robust increase in
monthly-mean daily precipitation extremes. Higher precipitation percentiles have
a greater sensitivity to convective organization, which is predicted to increase
with warming. Without changes in organization, the strongest daily precipitation
extremes over the tropical oceans increase at a rate close to Clausius-Clapeyron
(CC) scaling. Thus, in a future warmer state with increased organization, the
strongest daily precipitation extremes over oceans increase at a faster rate than
CC scaling.
acknowledgement: This work is supported by the Max-Planck-Gesellschaft (MPG). We greatly
appreciate computational resources from Deutsches Klimarechenzentrum (DKRZ) and
the Jülich Supercomputing Centre (JSC). ICONA/O simulations are funded through the
NextGEMS project by the EU’s Horizon 2020 programme (grant agreement no. 101003470).
ICONA simulations are funded through the MONSOON-2.0 project (grant agreement no.
01LP1927A) which is supported from German Federal Ministry of Education and Research
(BMBF). J.B. acknowledges funding from the European Union’s Horizon 2020 research
and innovation programme under the Marie Skłodowska-Curie grant (grant agreement
no. 101034413). B.S. acknowledges funding from the EU’s Horizon 2020 programme (grant
agreement no. 101003470). C.M. gratefully acknowledges funding from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (Project CLUSTER, grant agreement no. 805041).
article_number: eadj6801
article_processing_charge: Yes
article_type: original
author:
- first_name: Jiawei
full_name: Bao, Jiawei
id: bb9a7399-fefd-11ed-be3c-ae648fd1d160
last_name: Bao
- first_name: Bjorn
full_name: Stevens, Bjorn
last_name: Stevens
- first_name: Lukas
full_name: Kluft, Lukas
last_name: Kluft
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
citation:
ama: Bao J, Stevens B, Kluft L, Muller CJ. Intensification of daily tropical precipitation
extremes from more organized convection. Science Advances. 2024;10(8).
doi:10.1126/sciadv.adj6801
apa: Bao, J., Stevens, B., Kluft, L., & Muller, C. J. (2024). Intensification
of daily tropical precipitation extremes from more organized convection. Science
Advances. American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.adj6801
chicago: Bao, Jiawei, Bjorn Stevens, Lukas Kluft, and Caroline J Muller. “Intensification
of Daily Tropical Precipitation Extremes from More Organized Convection.” Science
Advances. American Association for the Advancement of Science, 2024. https://doi.org/10.1126/sciadv.adj6801.
ieee: J. Bao, B. Stevens, L. Kluft, and C. J. Muller, “Intensification of daily
tropical precipitation extremes from more organized convection,” Science Advances,
vol. 10, no. 8. American Association for the Advancement of Science, 2024.
ista: Bao J, Stevens B, Kluft L, Muller CJ. 2024. Intensification of daily tropical
precipitation extremes from more organized convection. Science Advances. 10(8),
eadj6801.
mla: Bao, Jiawei, et al. “Intensification of Daily Tropical Precipitation Extremes
from More Organized Convection.” Science Advances, vol. 10, no. 8, eadj6801,
American Association for the Advancement of Science, 2024, doi:10.1126/sciadv.adj6801.
short: J. Bao, B. Stevens, L. Kluft, C.J. Muller, Science Advances 10 (2024).
date_created: 2024-03-03T23:00:50Z
date_published: 2024-02-23T00:00:00Z
date_updated: 2025-09-04T12:11:18Z
day: '23'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1126/sciadv.adj6801
ec_funded: 1
external_id:
isi:
- '001300045100007'
pmid:
- '38394192'
file:
- access_level: open_access
checksum: d4ec4f05a6d14745057e14d1b8bf45ae
content_type: application/pdf
creator: dernst
date_created: 2024-03-04T07:34:00Z
date_updated: 2024-03-04T07:34:00Z
file_id: '15051'
file_name: 2024_ScienceAdv_Bao.pdf
file_size: 800926
relation: main_file
success: 1
file_date_updated: 2024-03-04T07:34:00Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '8'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: 629205d8-2b32-11ec-9570-e1356ff73576
call_identifier: H2020
grant_number: '805041'
name: Organization of CLoUdS, and implications of Tropical cyclones and for the
Energetics of the tropics, in current and waRming climate
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/cloud-clustering-causes-more-extreme-rain/
scopus_import: '1'
status: public
title: Intensification of daily tropical precipitation extremes from more organized
convection
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 10
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '15179'
abstract:
- lang: eng
text: The fungal bioluminescence pathway can be reconstituted in other organisms
allowing luminescence imaging without exogenously supplied substrate. The pathway
starts from hispidin biosynthesis—a step catalyzed by a large fungal polyketide
synthase that requires a posttranslational modification for activity. Here, we
report identification of alternative compact hispidin synthases encoded by a phylogenetically
diverse group of plants. A hybrid bioluminescence pathway that combines plant
and fungal genes is more compact, not dependent on availability of machinery for
posttranslational modifications, and confers autonomous bioluminescence in yeast,
mammalian, and plant hosts. The compact size of plant hispidin synthases enables
additional modes of delivery of autoluminescence, such as delivery with viral
vectors.
acknowledgement: "We thank Milaboratory (milaboratory.com) for the access to computing
and storage infrastructure. We thank J. Petrasek for providing the BY-2 cell culture
line. We thank Konstantin Lukyanov laboratory and Sergey Deyev laboratory for assistance
with experiments.\r\nThis study was partially funded by Light Bio and Planta. The
Synthetic biology Group is funded by the MRC London Institute of Medical Sciences
(UKRI MC-A658-5QEA0). Cloning and luminescent assays performed in BY-2 were partially
supported by RSF, project number 22-14-00400, https://rscf.ru/project/22-14-00400/.
Plant transformations were funded by RFBR and MOST, project number 21-54-52004.
Plant imaging experiments were funded by RSF, project number 22-74-00124, https://rscf.ru/project/22-74-00124/.
Viral delivery experiments were funded by the grant PID2019-108203RB-I00 Plan Nacional
I + D from the Ministerio de Ciencia e Innovación (Spain) through the Agencia Estatal
de Investigación (cofinanced by the European Regional Development Fund)."
article_number: adk1992
article_processing_charge: Yes
article_type: original
author:
- first_name: Kseniia A.
full_name: Palkina, Kseniia A.
last_name: Palkina
- first_name: Tatiana A.
full_name: Karataeva, Tatiana A.
last_name: Karataeva
- first_name: Maxim M.
full_name: Perfilov, Maxim M.
last_name: Perfilov
- first_name: Liliia I.
full_name: Fakhranurova, Liliia I.
last_name: Fakhranurova
- first_name: Nadezhda M.
full_name: Markina, Nadezhda M.
last_name: Markina
- first_name: Louisa
full_name: Gonzalez Somermeyer, Louisa
id: 4720D23C-F248-11E8-B48F-1D18A9856A87
last_name: Gonzalez Somermeyer
orcid: 0000-0001-9139-5383
- first_name: Elena
full_name: Garcia-Perez, Elena
last_name: Garcia-Perez
- first_name: Marta
full_name: Vazquez-Vilar, Marta
last_name: Vazquez-Vilar
- first_name: Marta
full_name: Rodriguez-Rodriguez, Marta
last_name: Rodriguez-Rodriguez
- first_name: Victor
full_name: Vazquez-Vilriales, Victor
last_name: Vazquez-Vilriales
- first_name: Ekaterina S.
full_name: Shakhova, Ekaterina S.
last_name: Shakhova
- first_name: Tatiana
full_name: Mitiouchkina, Tatiana
last_name: Mitiouchkina
- first_name: Olga A.
full_name: Belozerova, Olga A.
last_name: Belozerova
- first_name: Sergey I.
full_name: Kovalchuk, Sergey I.
last_name: Kovalchuk
- first_name: Anna
full_name: Alekberova, Anna
last_name: Alekberova
- first_name: Alena K.
full_name: Malyshevskaia, Alena K.
last_name: Malyshevskaia
- first_name: Evgenia N.
full_name: Bugaeva, Evgenia N.
last_name: Bugaeva
- first_name: Elena B.
full_name: Guglya, Elena B.
last_name: Guglya
- first_name: Anastasia
full_name: Balakireva, Anastasia
last_name: Balakireva
- first_name: Nikita
full_name: Sytov, Nikita
last_name: Sytov
- first_name: Anastasia
full_name: Bezlikhotnova, Anastasia
last_name: Bezlikhotnova
- first_name: Daria I.
full_name: Boldyreva, Daria I.
last_name: Boldyreva
- first_name: Vladislav V.
full_name: Babenko, Vladislav V.
last_name: Babenko
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
- first_name: Vladimir V.
full_name: Choob, Vladimir V.
last_name: Choob
- first_name: Diego
full_name: Orzaez, Diego
last_name: Orzaez
- first_name: Ilia V.
full_name: Yampolsky, Ilia V.
last_name: Yampolsky
- first_name: Alexander S.
full_name: Mishin, Alexander S.
last_name: Mishin
- first_name: Karen S.
full_name: Sarkisyan, Karen S.
last_name: Sarkisyan
citation:
ama: Palkina KA, Karataeva TA, Perfilov MM, et al. A hybrid pathway for self-sustained
luminescence. Science Advances. 2024;10(10). doi:10.1126/sciadv.adk1992
apa: Palkina, K. A., Karataeva, T. A., Perfilov, M. M., Fakhranurova, L. I., Markina,
N. M., Gonzalez Somermeyer, L., … Sarkisyan, K. S. (2024). A hybrid pathway for
self-sustained luminescence. Science Advances. American Association for
the Advancement of Science. https://doi.org/10.1126/sciadv.adk1992
chicago: Palkina, Kseniia A., Tatiana A. Karataeva, Maxim M. Perfilov, Liliia I.
Fakhranurova, Nadezhda M. Markina, Louisa Gonzalez Somermeyer, Elena Garcia-Perez,
et al. “A Hybrid Pathway for Self-Sustained Luminescence.” Science Advances.
American Association for the Advancement of Science, 2024. https://doi.org/10.1126/sciadv.adk1992.
ieee: K. A. Palkina et al., “A hybrid pathway for self-sustained luminescence,”
Science Advances, vol. 10, no. 10. American Association for the Advancement
of Science, 2024.
ista: Palkina KA, Karataeva TA, Perfilov MM, Fakhranurova LI, Markina NM, Gonzalez
Somermeyer L, Garcia-Perez E, Vazquez-Vilar M, Rodriguez-Rodriguez M, Vazquez-Vilriales
V, Shakhova ES, Mitiouchkina T, Belozerova OA, Kovalchuk SI, Alekberova A, Malyshevskaia
AK, Bugaeva EN, Guglya EB, Balakireva A, Sytov N, Bezlikhotnova A, Boldyreva DI,
Babenko VV, Kondrashov F, Choob VV, Orzaez D, Yampolsky IV, Mishin AS, Sarkisyan
KS. 2024. A hybrid pathway for self-sustained luminescence. Science Advances.
10(10), adk1992.
mla: Palkina, Kseniia A., et al. “A Hybrid Pathway for Self-Sustained Luminescence.”
Science Advances, vol. 10, no. 10, adk1992, American Association for the
Advancement of Science, 2024, doi:10.1126/sciadv.adk1992.
short: K.A. Palkina, T.A. Karataeva, M.M. Perfilov, L.I. Fakhranurova, N.M. Markina,
L. Gonzalez Somermeyer, E. Garcia-Perez, M. Vazquez-Vilar, M. Rodriguez-Rodriguez,
V. Vazquez-Vilriales, E.S. Shakhova, T. Mitiouchkina, O.A. Belozerova, S.I. Kovalchuk,
A. Alekberova, A.K. Malyshevskaia, E.N. Bugaeva, E.B. Guglya, A. Balakireva, N.
Sytov, A. Bezlikhotnova, D.I. Boldyreva, V.V. Babenko, F. Kondrashov, V.V. Choob,
D. Orzaez, I.V. Yampolsky, A.S. Mishin, K.S. Sarkisyan, Science Advances 10 (2024).
date_created: 2024-03-25T08:54:33Z
date_published: 2024-03-01T00:00:00Z
date_updated: 2025-09-04T13:16:05Z
day: '01'
ddc:
- '580'
department:
- _id: FyKo
doi: 10.1126/sciadv.adk1992
external_id:
isi:
- '001187580500013'
pmid:
- '38457503'
file:
- access_level: open_access
checksum: a19c43b260ea0bbaf895a29712e3153c
content_type: application/pdf
creator: dernst
date_created: 2024-03-25T09:42:10Z
date_updated: 2024-03-25T09:42:10Z
file_id: '15185'
file_name: 2024_ScienceAdv_Palkina.pdf
file_size: 1499302
relation: main_file
success: 1
file_date_updated: 2024-03-25T09:42:10Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '10'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: A hybrid pathway for self-sustained luminescence
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 10
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '17280'
abstract:
- lang: eng
text: Adherens junction–associated protein 1 (AJAP1) has been implicated in brain
diseases; however, a pathogenic mechanism has not been identified. AJAP1 is widely
expressed in neurons and binds to γ-aminobutyric acid type B receptors (GBRs),
which inhibit neurotransmitter release at most synapses in the brain. Here, we
show that AJAP1 is selectively expressed in dendrites and trans-synaptically recruits
GBRs to presynaptic sites of neurons expressing AJAP1. We have identified several
monoallelic AJAP1 variants in individuals with epilepsy and/or neurodevelopmental
disorders. Specifically, we show that the variant p.(W183C) lacks binding to GBRs,
resulting in the inability to recruit them. Ultrastructural analysis revealed
significantly decreased presynaptic GBR levels in Ajap1−/− and Ajap1W183C/+ mice.
Consequently, these mice exhibited reduced GBR-mediated presynaptic inhibition
at excitatory and inhibitory synapses, along with impaired synaptic plasticity.
Our study reveals that AJAP1 enables the postsynaptic neuron to regulate the level
of presynaptic GBR-mediated inhibition, supporting the clinical relevance of loss-of-function
AJAP1 variants.
acknowledgement: "Ajap1HA/HA and Ajap1W183C/+ mice were generated in collaboration
with Pawel Pelczar at the center for transgenic models at the University of Basel,
Switzerland. We thank the imaging core facility (IMCF, University of Basel) and
in particular A. Ferrand for the technical assistance provided on the OMX 3D-SIM
microscope.\r\nThis work was supported by a grant from the Swiss National Science
Foundation (SNF) to B.B. (31003A-152970, 310030B-201291), an NIH grant to E.A. and
E.H.S. (R01NS058721), DFG grants to B.F. (TRR 152 project ID 239283807, FA 332/15-1,
16-1), and grants to P.S. from AIMS-2-TRIALS, which are supported by the Innovative
Medicines Initiatives from the European Commission joint undertaking under grant
agreement No 777394."
article_number: adk5462
article_processing_charge: Yes
article_type: original
author:
- first_name: Simon
full_name: Früh, Simon
last_name: Früh
- first_name: Sami
full_name: Boudkkazi, Sami
last_name: Boudkkazi
- first_name: Peter
full_name: Koppensteiner, Peter
id: 3B8B25A8-F248-11E8-B48F-1D18A9856A87
last_name: Koppensteiner
orcid: 0000-0002-3509-1948
- first_name: Vita
full_name: Sereikaite, Vita
last_name: Sereikaite
- first_name: Li Yuan
full_name: Chen, Li Yuan
last_name: Chen
- first_name: Diego
full_name: Fernandez-Fernandez, Diego
last_name: Fernandez-Fernandez
- first_name: Pascal D.
full_name: Rem, Pascal D.
last_name: Rem
- first_name: Daniel
full_name: Ulrich, Daniel
last_name: Ulrich
- first_name: Jochen
full_name: Schwenk, Jochen
last_name: Schwenk
- first_name: Ziyang
full_name: Chen, Ziyang
last_name: Chen
- first_name: Elodie Le
full_name: Monnier, Elodie Le
last_name: Monnier
- first_name: Thorsten
full_name: Fritzius, Thorsten
last_name: Fritzius
- first_name: Sabrina M.
full_name: Innocenti, Sabrina M.
last_name: Innocenti
- first_name: Valérie
full_name: Besseyrias, Valérie
last_name: Besseyrias
- first_name: Luca
full_name: Trovò, Luca
last_name: Trovò
- first_name: Michal
full_name: Stawarski, Michal
last_name: Stawarski
- first_name: Emanuela
full_name: Argilli, Emanuela
last_name: Argilli
- first_name: Elliott H.
full_name: Sherr, Elliott H.
last_name: Sherr
- first_name: Bregje
full_name: Van Bon, Bregje
last_name: Van Bon
- first_name: Erik Jan
full_name: Kamsteeg, Erik Jan
last_name: Kamsteeg
- first_name: Maria
full_name: Iascone, Maria
last_name: Iascone
- first_name: Alba
full_name: Pilotta, Alba
last_name: Pilotta
- first_name: Maria R.
full_name: Cutrì, Maria R.
last_name: Cutrì
- first_name: Mahshid S.
full_name: Azamian, Mahshid S.
last_name: Azamian
- first_name: Andrés
full_name: Hernández-García, Andrés
last_name: Hernández-García
- first_name: Seema R.
full_name: Lalani, Seema R.
last_name: Lalani
- first_name: Jill A.
full_name: Rosenfeld, Jill A.
last_name: Rosenfeld
- first_name: Xiaonan
full_name: Zhao, Xiaonan
last_name: Zhao
- first_name: Tiphanie P.
full_name: Vogel, Tiphanie P.
last_name: Vogel
- first_name: Herda
full_name: Ona, Herda
last_name: Ona
- first_name: Daryl A.
full_name: Scott, Daryl A.
last_name: Scott
- first_name: Peter
full_name: Scheiffele, Peter
last_name: Scheiffele
- first_name: Kristian
full_name: Strømgaard, Kristian
last_name: Strømgaard
- first_name: Mehdi
full_name: Tafti, Mehdi
last_name: Tafti
- first_name: Martin
full_name: Gassmann, Martin
last_name: Gassmann
- first_name: Bernd
full_name: Fakler, Bernd
last_name: Fakler
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
citation:
ama: Früh S, Boudkkazi S, Koppensteiner P, et al. Monoallelic de novo AJAP1 loss-of-
function variants disrupt trans-synaptic control of neurotransmitter release.
Science Advances. 2024;10(28). doi:10.1126/sciadv.adk5462
apa: Früh, S., Boudkkazi, S., Koppensteiner, P., Sereikaite, V., Chen, L. Y., Fernandez-Fernandez,
D., … Bettler, B. (2024). Monoallelic de novo AJAP1 loss-of- function variants
disrupt trans-synaptic control of neurotransmitter release. Science Advances.
American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.adk5462
chicago: Früh, Simon, Sami Boudkkazi, Peter Koppensteiner, Vita Sereikaite, Li Yuan
Chen, Diego Fernandez-Fernandez, Pascal D. Rem, et al. “Monoallelic de Novo AJAP1
Loss-of- Function Variants Disrupt Trans-Synaptic Control of Neurotransmitter
Release.” Science Advances. American Association for the Advancement of
Science, 2024. https://doi.org/10.1126/sciadv.adk5462.
ieee: S. Früh et al., “Monoallelic de novo AJAP1 loss-of- function variants
disrupt trans-synaptic control of neurotransmitter release,” Science Advances,
vol. 10, no. 28. American Association for the Advancement of Science, 2024.
ista: Früh S, Boudkkazi S, Koppensteiner P, Sereikaite V, Chen LY, Fernandez-Fernandez
D, Rem PD, Ulrich D, Schwenk J, Chen Z, Monnier EL, Fritzius T, Innocenti SM,
Besseyrias V, Trovò L, Stawarski M, Argilli E, Sherr EH, Van Bon B, Kamsteeg EJ,
Iascone M, Pilotta A, Cutrì MR, Azamian MS, Hernández-García A, Lalani SR, Rosenfeld
JA, Zhao X, Vogel TP, Ona H, Scott DA, Scheiffele P, Strømgaard K, Tafti M, Gassmann
M, Fakler B, Shigemoto R, Bettler B. 2024. Monoallelic de novo AJAP1 loss-of-
function variants disrupt trans-synaptic control of neurotransmitter release.
Science Advances. 10(28), adk5462.
mla: Früh, Simon, et al. “Monoallelic de Novo AJAP1 Loss-of- Function Variants Disrupt
Trans-Synaptic Control of Neurotransmitter Release.” Science Advances,
vol. 10, no. 28, adk5462, American Association for the Advancement of Science,
2024, doi:10.1126/sciadv.adk5462.
short: S. Früh, S. Boudkkazi, P. Koppensteiner, V. Sereikaite, L.Y. Chen, D. Fernandez-Fernandez,
P.D. Rem, D. Ulrich, J. Schwenk, Z. Chen, E.L. Monnier, T. Fritzius, S.M. Innocenti,
V. Besseyrias, L. Trovò, M. Stawarski, E. Argilli, E.H. Sherr, B. Van Bon, E.J.
Kamsteeg, M. Iascone, A. Pilotta, M.R. Cutrì, M.S. Azamian, A. Hernández-García,
S.R. Lalani, J.A. Rosenfeld, X. Zhao, T.P. Vogel, H. Ona, D.A. Scott, P. Scheiffele,
K. Strømgaard, M. Tafti, M. Gassmann, B. Fakler, R. Shigemoto, B. Bettler, Science
Advances 10 (2024).
date_created: 2024-07-21T22:01:01Z
date_published: 2024-07-12T00:00:00Z
date_updated: 2025-09-08T08:15:54Z
day: '12'
ddc:
- '570'
department:
- _id: RySh
- _id: PreCl
doi: 10.1126/sciadv.adk5462
external_id:
isi:
- '001280159000022'
pmid:
- '38985877'
file:
- access_level: open_access
checksum: 9cbc4501fcd4ba1c0811fd244031422b
content_type: application/pdf
creator: dernst
date_created: 2024-07-22T06:29:27Z
date_updated: 2024-07-22T06:29:27Z
file_id: '17287'
file_name: 2024_ScienceAdv_Früh.pdf
file_size: 7241489
relation: main_file
success: 1
file_date_updated: 2024-07-22T06:29:27Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '28'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Monoallelic de novo AJAP1 loss-of- function variants disrupt trans-synaptic
control of neurotransmitter release
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 10
year: '2024'
...
---
APC_amount: 4569,23 EUR
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '18491'
abstract:
- lang: eng
text: Predicting the outcomes of adaptation is a major goal of evolutionary biology.
When temporal changes in the environment mirror spatial gradients, it opens up
the potential for predicting the course of adaptive evolution over time based
on patterns of spatial genetic and phenotypic variation. We assessed this approach
in a 30-year transplant experiment in the intertidal snail Littorina saxatilis.
In 1992, snails were transplanted from a predation-dominated environment to one
dominated by wave action. On the basis of spatial patterns, we predicted transitions
in shell size and morphology, allele frequencies at positions throughout the genome,
and chromosomal rearrangement frequencies. Observed changes closely agreed with
predictions and transformation was both dramatic and rapid. Hence, adaptation
can be predicted from knowledge of the phenotypic and genetic variation among
populations.
acknowledgement: 'This work was received funding from the following: Norwegian Research
Council RCN project 315287 (A.M.W.), Swedish Research Council 2021-04191 (K.J.),
European Research Council grant 101055327 HaplotypeStructure (N.B.), Austrian Science
Fund FWF; P 32166-B32 Snapdragon Speciation (N.B.), European Research Council (R.B.),
and Portuguese Foundation for Science and Technology FCT: 2020.00275.CEECIND and
PTDC/BIA-EVL/1614/2021 (R.F.).'
article_number: eadp2102
article_processing_charge: Yes
article_type: original
author:
- first_name: Diego Fernando
full_name: Garcia Castillo, Diego Fernando
id: ae681a14-dc74-11ea-a0a7-c6ef18161701
last_name: Garcia Castillo
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Jenny
full_name: Larsson, Jenny
last_name: Larsson
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
citation:
ama: 'Garcia Castillo DF, Barton NH, Faria R, et al. Predicting rapid adaptation
in time from adaptation in space: A 30-year field experiment in marine snails.
Science Advances. 2024;10(41). doi:10.1126/sciadv.adp2102'
apa: 'Garcia Castillo, D. F., Barton, N. H., Faria, R., Larsson, J., Stankowski,
S., Butlin, R., … Westram, A. M. (2024). Predicting rapid adaptation in time from
adaptation in space: A 30-year field experiment in marine snails. Science Advances.
AAAS. https://doi.org/10.1126/sciadv.adp2102'
chicago: 'Garcia Castillo, Diego Fernando, Nicholas H Barton, Rui Faria, Jenny Larsson,
Sean Stankowski, Roger Butlin, Kerstin Johannesson, and Anja M Westram. “Predicting
Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment
in Marine Snails.” Science Advances. AAAS, 2024. https://doi.org/10.1126/sciadv.adp2102.'
ieee: 'D. F. Garcia Castillo et al., “Predicting rapid adaptation in time
from adaptation in space: A 30-year field experiment in marine snails,” Science
Advances, vol. 10, no. 41. AAAS, 2024.'
ista: 'Garcia Castillo DF, Barton NH, Faria R, Larsson J, Stankowski S, Butlin R,
Johannesson K, Westram AM. 2024. Predicting rapid adaptation in time from adaptation
in space: A 30-year field experiment in marine snails. Science Advances. 10(41),
eadp2102.'
mla: 'Garcia Castillo, Diego Fernando, et al. “Predicting Rapid Adaptation in Time
from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” Science
Advances, vol. 10, no. 41, eadp2102, AAAS, 2024, doi:10.1126/sciadv.adp2102.'
short: D.F. Garcia Castillo, N.H. Barton, R. Faria, J. Larsson, S. Stankowski, R.
Butlin, K. Johannesson, A.M. Westram, Science Advances 10 (2024).
corr_author: '1'
date_created: 2024-11-03T23:01:44Z
date_published: 2024-10-11T00:00:00Z
date_updated: 2026-04-07T11:42:09Z
day: '11'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1126/sciadv.adp2102
external_id:
isi:
- '001354405400018'
file:
- access_level: open_access
checksum: 96aa0d3640fa9401975138e59054f84e
content_type: application/pdf
creator: dernst
date_created: 2024-11-04T09:35:49Z
date_updated: 2024-11-04T09:35:49Z
file_id: '18499'
file_name: 2024_ScienceAdv_Castillo.pdf
file_size: 1154107
relation: main_file
success: 1
file_date_updated: 2024-11-04T09:35:49Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
issue: '41'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: bd6958e0-d553-11ed-ba76-86eba6a76c00
grant_number: '101055327'
name: Understanding the evolution of continuous genomes
- _id: 05959E1C-7A3F-11EA-A408-12923DDC885E
grant_number: P32166
name: Snapdragon Speciation
- _id: 3AC91DDA-15DF-11EA-824D-93A3E7B544D1
call_identifier: FWF
name: FWF Open Access Fund
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/fernandoGarcia21/littorina_saxatilis_skerry
record:
- id: '18498'
relation: research_data
status: public
- id: '20991'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'Predicting rapid adaptation in time from adaptation in space: A 30-year field
experiment in marine snails'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 10
year: '2024'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21582'
abstract:
- lang: eng
text: 'Scintillation materials convert high-energy radiation to optical light through
a complex multistage process. The last stage of the process is spontaneous light
emission, which usually governs and limits the scintillator emission rate and
light yield. For decades, scintillator research focused on developing faster-emitting
materials or external photonic coatings for improving light yields. Here, we experimentally
demonstrate a fundamentally different approach: enhancing the scintillation rate
and yield via the Purcell effect, utilizing optical environment engineering to
boost spontaneous emission. This enhancement is universally applicable to any
scintillating material and dopant when the material’s nanoscale geometry is engineered.
We design a thin multilayer nanophotonic scintillator, demonstrating Purcell-enhanced
scintillation with 50% enhancement in emission rate and 80% enhancement in light
yield. The emission is robust to fabrication disorder, further highlighting its
potential for x-ray applications. Our results show prospects for bridging nanophotonics
and scintillator science toward reduced radiation dosage and increased resolution
for high-energy particle detection.'
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Yaniv
full_name: Kurman, Yaniv
last_name: Kurman
- first_name: Neta
full_name: Lahav, Neta
last_name: Lahav
- first_name: Roman
full_name: Schuetz, Roman
last_name: Schuetz
- first_name: Avner
full_name: Shultzman, Avner
last_name: Shultzman
- first_name: Charles
full_name: Roques-Carmes, Charles
id: e2e68fc9-6505-11ef-a541-eb4e72cc3e82
last_name: Roques-Carmes
- first_name: Alon
full_name: Lifshits, Alon
last_name: Lifshits
- first_name: Segev
full_name: Zaken, Segev
last_name: Zaken
- first_name: Tom
full_name: Lenkiewicz, Tom
last_name: Lenkiewicz
- first_name: Rotem
full_name: Strassberg, Rotem
last_name: Strassberg
- first_name: Orr
full_name: Be’er, Orr
last_name: Be’er
- first_name: Yehonadav
full_name: Bekenstein, Yehonadav
last_name: Bekenstein
- first_name: Ido
full_name: Kaminer, Ido
last_name: Kaminer
citation:
ama: Kurman Y, Lahav N, Schuetz R, et al. Purcell-enhanced x-ray scintillation.
Science Advances. 2024;10(44). doi:10.1126/sciadv.adq6325
apa: Kurman, Y., Lahav, N., Schuetz, R., Shultzman, A., Roques-Carmes, C., Lifshits,
A., … Kaminer, I. (2024). Purcell-enhanced x-ray scintillation. Science Advances.
American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.adq6325
chicago: Kurman, Yaniv, Neta Lahav, Roman Schuetz, Avner Shultzman, Charles Roques-Carmes,
Alon Lifshits, Segev Zaken, et al. “Purcell-Enhanced x-Ray Scintillation.” Science
Advances. American Association for the Advancement of Science, 2024. https://doi.org/10.1126/sciadv.adq6325.
ieee: Y. Kurman et al., “Purcell-enhanced x-ray scintillation,” Science
Advances, vol. 10, no. 44. American Association for the Advancement of Science,
2024.
ista: Kurman Y, Lahav N, Schuetz R, Shultzman A, Roques-Carmes C, Lifshits A, Zaken
S, Lenkiewicz T, Strassberg R, Be’er O, Bekenstein Y, Kaminer I. 2024. Purcell-enhanced
x-ray scintillation. Science Advances. 10(44).
mla: Kurman, Yaniv, et al. “Purcell-Enhanced x-Ray Scintillation.” Science Advances,
vol. 10, no. 44, American Association for the Advancement of Science, 2024, doi:10.1126/sciadv.adq6325.
short: Y. Kurman, N. Lahav, R. Schuetz, A. Shultzman, C. Roques-Carmes, A. Lifshits,
S. Zaken, T. Lenkiewicz, R. Strassberg, O. Be’er, Y. Bekenstein, I. Kaminer, Science
Advances 10 (2024).
date_created: 2026-03-30T12:22:48Z
date_published: 2024-11-01T00:00:00Z
date_updated: 2026-04-27T09:31:51Z
day: '01'
ddc:
- '530'
doi: 10.1126/sciadv.adq6325
extern: '1'
external_id:
arxiv:
- '2302.01300'
pmid:
- '39485836'
intvolume: ' 10'
issue: '44'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1126/sciadv.adq6325
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Purcell-enhanced x-ray scintillation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 10
year: '2024'
...
---
_id: '12756'
abstract:
- lang: eng
text: ESCRT-III family proteins form composite polymers that deform and cut membrane
tubes in the context of a wide range of cell biological processes across the tree
of life. In reconstituted systems, sequential changes in the composition of ESCRT-III
polymers induced by the AAA–adenosine triphosphatase Vps4 have been shown to remodel
membranes. However, it is not known how composite ESCRT-III polymers are organized
and remodeled in space and time in a cellular context. Taking advantage of the
relative simplicity of the ESCRT-III–dependent division system in Sulfolobus acidocaldarius,
one of the closest experimentally tractable prokaryotic relatives of eukaryotes,
we use super-resolution microscopy, electron microscopy, and computational modeling
to show how CdvB/CdvB1/CdvB2 proteins form a precisely patterned composite ESCRT-III
division ring, which undergoes stepwise Vps4-dependent disassembly and contracts
to cut cells into two. These observations lead us to suggest sequential changes
in a patterned composite polymer as a general mechanism of ESCRT-III–dependent
membrane remodeling.
acknowledgement: "We thank Y. Liu and V. Hale for help with electron cryotomography;
the Medical Research Council (MRC) LMB Electron Microscopy Facility for access,
training, and support; and T. Darling and J. Grimmett at the MRC LMB for help with
computing infrastructure. We also thank the Flow Cytometry Facility and the MRC
LMB for training and support.\r\n F.H. and G.T.-R. were supported by a grant from
the Wellcome Trust (203276/Z/16/Z). A.C. was supported by an EMBO long-term fellowship:
ALTF_1041-2021. J.T. was supported by a grant from the VW Foundation (94933). A.A.P.
was supported by the Wellcome Trust (203276/Z/16/Z) and the HFSP (LT001027/2019).
B.B. received support from the MRC LMB, the Wellcome Trust (203276/Z/16/Z), the
VW Foundation (94933), the Life Sciences–Moore-Simons Foundation (735929LPI), and
a Gordon and Betty Moore Foundation’s Symbiosis in Aquatic Systems Initiative (9346).
A.Š. and X.J. acknowledge funding from the European Research Council (ERC) under
the European Union’s Horizon 2020 research and innovation programme (grant no. 802960).
L.H.-K. acknowledges support from Biotechnology and Biological Sciences Research
Council LIDo Programme. T.N. and J.L. were supported by the MRC (U105184326) and
the Wellcome Trust (203276/Z/16/Z)."
article_number: eade5224
article_processing_charge: No
article_type: original
author:
- first_name: Fredrik
full_name: Hurtig, Fredrik
last_name: Hurtig
- first_name: Thomas C.Q.
full_name: Burgers, Thomas C.Q.
last_name: Burgers
- first_name: Alice
full_name: Cezanne, Alice
last_name: Cezanne
- first_name: Xiuyun
full_name: Jiang, Xiuyun
last_name: Jiang
- first_name: Frank N.
full_name: Mol, Frank N.
last_name: Mol
- first_name: Jovan
full_name: Traparić, Jovan
last_name: Traparić
- first_name: Andre Arashiro
full_name: Pulschen, Andre Arashiro
last_name: Pulschen
- first_name: Tim
full_name: Nierhaus, Tim
last_name: Nierhaus
- first_name: Gabriel
full_name: Tarrason-Risa, Gabriel
last_name: Tarrason-Risa
- first_name: Lena
full_name: Harker-Kirschneck, Lena
last_name: Harker-Kirschneck
- first_name: Jan
full_name: Löwe, Jan
last_name: Löwe
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Rifka
full_name: Vlijm, Rifka
last_name: Vlijm
- first_name: Buzz
full_name: Baum, Buzz
last_name: Baum
citation:
ama: Hurtig F, Burgers TCQ, Cezanne A, et al. The patterned assembly and stepwise
Vps4-mediated disassembly of composite ESCRT-III polymers drives archaeal cell
division. Science Advances. 2023;9(11). doi:10.1126/sciadv.ade5224
apa: Hurtig, F., Burgers, T. C. Q., Cezanne, A., Jiang, X., Mol, F. N., Traparić,
J., … Baum, B. (2023). The patterned assembly and stepwise Vps4-mediated disassembly
of composite ESCRT-III polymers drives archaeal cell division. Science Advances.
American Association for the Advancement of Science. https://doi.org/10.1126/sciadv.ade5224
chicago: Hurtig, Fredrik, Thomas C.Q. Burgers, Alice Cezanne, Xiuyun Jiang, Frank
N. Mol, Jovan Traparić, Andre Arashiro Pulschen, et al. “The Patterned Assembly
and Stepwise Vps4-Mediated Disassembly of Composite ESCRT-III Polymers Drives
Archaeal Cell Division.” Science Advances. American Association for the
Advancement of Science, 2023. https://doi.org/10.1126/sciadv.ade5224.
ieee: F. Hurtig et al., “The patterned assembly and stepwise Vps4-mediated
disassembly of composite ESCRT-III polymers drives archaeal cell division,” Science
Advances, vol. 9, no. 11. American Association for the Advancement of Science,
2023.
ista: Hurtig F, Burgers TCQ, Cezanne A, Jiang X, Mol FN, Traparić J, Pulschen AA,
Nierhaus T, Tarrason-Risa G, Harker-Kirschneck L, Löwe J, Šarić A, Vlijm R, Baum
B. 2023. The patterned assembly and stepwise Vps4-mediated disassembly of composite
ESCRT-III polymers drives archaeal cell division. Science Advances. 9(11), eade5224.
mla: Hurtig, Fredrik, et al. “The Patterned Assembly and Stepwise Vps4-Mediated
Disassembly of Composite ESCRT-III Polymers Drives Archaeal Cell Division.” Science
Advances, vol. 9, no. 11, eade5224, American Association for the Advancement
of Science, 2023, doi:10.1126/sciadv.ade5224.
short: F. Hurtig, T.C.Q. Burgers, A. Cezanne, X. Jiang, F.N. Mol, J. Traparić, A.A.
Pulschen, T. Nierhaus, G. Tarrason-Risa, L. Harker-Kirschneck, J. Löwe, A. Šarić,
R. Vlijm, B. Baum, Science Advances 9 (2023).
corr_author: '1'
date_created: 2023-03-26T22:01:06Z
date_published: 2023-03-17T00:00:00Z
date_updated: 2025-04-23T08:50:02Z
day: '17'
ddc:
- '570'
department:
- _id: AnSa
doi: 10.1126/sciadv.ade5224
ec_funded: 1
external_id:
isi:
- '000968083500010'
pmid:
- '36921039'
file:
- access_level: open_access
checksum: 6d7dbe9ed86a116c8a002d62971202c5
content_type: application/pdf
creator: dernst
date_created: 2023-03-27T06:24:49Z
date_updated: 2023-03-27T06:24:49Z
file_id: '12768'
file_name: 2023_ScienceAdvances_Hurtig.pdf
file_size: 1826471
relation: main_file
success: 1
file_date_updated: 2023-03-27T06:24:49Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '11'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: The patterned assembly and stepwise Vps4-mediated disassembly of composite
ESCRT-III polymers drives archaeal cell division
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2023'
...
---
_id: '13259'
abstract:
- lang: eng
text: Plants can regenerate their bodies via de novo establishment of shoot apical
meristems (SAMs) from pluripotent callus. Only a small fraction of callus cells
is eventually specified into SAMs but the molecular mechanisms underlying fate
specification remain obscure. The expression of WUSCHEL (WUS) is an early hallmark
of SAM fate acquisition. Here, we show that a WUS paralog, WUSCHEL-RELATED HOMEOBOX
13 (WOX13), negatively regulates SAM formation from callus in Arabidopsis thaliana.
WOX13 promotes non-meristematic cell fate via transcriptional repression of WUS
and other SAM regulators and activation of cell wall modifiers. Our Quartz-Seq2–based
single cell transcriptome revealed that WOX13 plays key roles in determining cellular
identity of callus cell population. We propose that reciprocal inhibition between
WUS and WOX13 mediates critical cell fate determination in pluripotent cell population,
which has a major impact on regeneration efficiency.
acknowledgement: Wethank Y.Iwayama, K.Ohtawa, K.Fukumoto,andN. Mataga (RIKENRRD) for
technical assistance in Quartz-Seq2analyses; M. Mouri(RIKENCSRS)for technical support
with plasmid construction and transactivation assay; Y. Ikeda (NAIST) for technical
support with tissue culture; and A. Furuta for technical support in bulk RNA-seq
analysis. We also thank the Single-cell Omics Laboratory for technical consultation
in scRNA-seq analyses, the members of the Laboratory for Bioinformatics Research
at the RIKEN Center for Biosystems Dynamics Research, and A. Matsushima and T. Ichikawa
for IT infrastructure management. This work was supported by JSPS KAKENHI(17K15146,19H05670,20K06712,20H04894,20H05431,and
22H04713 to M.I. and 20H03284 and 20H05911 to K.S.), by the JST FOREST Program (JPMJFR214H
to M.I.), by The Naito Foundation to M.I.; by Takeda Science Foundation to M.I,and
by the Shiseido Female Researcher Science Grant to M.I. This work was partially
supported by RIKENE pigenome Control Program, Medical Research Center Initiative
for High Depth Omics, and JST CREST(JPMJCR16G3and JPMJCR1926)to I.N.
article_processing_charge: Yes
article_type: original
author:
- first_name: Nao
full_name: Ogura, Nao
last_name: Ogura
- first_name: Yohei
full_name: Sasagawa, Yohei
last_name: Sasagawa
- first_name: Tasuku
full_name: Ito, Tasuku
id: d5a17a4a-e534-11eb-93ec-91fa2aa9bd57
last_name: Ito
orcid: 0000-0002-2482-9089
- first_name: Toshiaki
full_name: Tameshige, Toshiaki
last_name: Tameshige
- first_name: Satomi
full_name: Kawai, Satomi
last_name: Kawai
- first_name: Masaki
full_name: Sano, Masaki
last_name: Sano
- first_name: Yuki
full_name: Doll, Yuki
last_name: Doll
- first_name: Akira
full_name: Iwase, Akira
last_name: Iwase
- first_name: Ayako
full_name: Kawamura, Ayako
last_name: Kawamura
- first_name: Takamasa
full_name: Suzuki, Takamasa
last_name: Suzuki
- first_name: Itoshi
full_name: Nikaido, Itoshi
last_name: Nikaido
- first_name: Keiko
full_name: Sugimoto, Keiko
last_name: Sugimoto
- first_name: Momoko
full_name: Ikeuchi, Momoko
last_name: Ikeuchi
citation:
ama: Ogura N, Sasagawa Y, Ito T, et al. WUSCHEL-RELATED HOMEOBOX 13 suppresses de
novo shoot regeneration via cell fate control of pluripotent callus. Science
Advances. 2023;9(27):eadg6983. doi:10.1126/sciadv.adg6983
apa: Ogura, N., Sasagawa, Y., Ito, T., Tameshige, T., Kawai, S., Sano, M., … Ikeuchi,
M. (2023). WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via
cell fate control of pluripotent callus. Science Advances. American Association
for the Advancement of Science. https://doi.org/10.1126/sciadv.adg6983
chicago: Ogura, Nao, Yohei Sasagawa, Tasuku Ito, Toshiaki Tameshige, Satomi Kawai,
Masaki Sano, Yuki Doll, et al. “WUSCHEL-RELATED HOMEOBOX 13 Suppresses de Novo
Shoot Regeneration via Cell Fate Control of Pluripotent Callus.” Science Advances.
American Association for the Advancement of Science, 2023. https://doi.org/10.1126/sciadv.adg6983.
ieee: N. Ogura et al., “WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot
regeneration via cell fate control of pluripotent callus,” Science Advances,
vol. 9, no. 27. American Association for the Advancement of Science, p. eadg6983,
2023.
ista: Ogura N, Sasagawa Y, Ito T, Tameshige T, Kawai S, Sano M, Doll Y, Iwase A,
Kawamura A, Suzuki T, Nikaido I, Sugimoto K, Ikeuchi M. 2023. WUSCHEL-RELATED
HOMEOBOX 13 suppresses de novo shoot regeneration via cell fate control of pluripotent
callus. Science Advances. 9(27), eadg6983.
mla: Ogura, Nao, et al. “WUSCHEL-RELATED HOMEOBOX 13 Suppresses de Novo Shoot Regeneration
via Cell Fate Control of Pluripotent Callus.” Science Advances, vol. 9,
no. 27, American Association for the Advancement of Science, 2023, p. eadg6983,
doi:10.1126/sciadv.adg6983.
short: N. Ogura, Y. Sasagawa, T. Ito, T. Tameshige, S. Kawai, M. Sano, Y. Doll,
A. Iwase, A. Kawamura, T. Suzuki, I. Nikaido, K. Sugimoto, M. Ikeuchi, Science
Advances 9 (2023) eadg6983.
date_created: 2023-07-23T22:01:11Z
date_published: 2023-07-07T00:00:00Z
date_updated: 2023-12-13T11:59:29Z
day: '07'
ddc:
- '580'
doi: 10.1126/sciadv.adg6983
external_id:
isi:
- '001030983100012'
pmid:
- '37418524'
file:
- access_level: open_access
checksum: f59217e1083767777318b5d0cc5e141d
content_type: application/pdf
creator: dernst
date_created: 2023-08-01T06:40:35Z
date_updated: 2023-08-01T06:40:35Z
file_id: '13338'
file_name: 2023_ScienceAdvance_Ogura.pdf
file_size: 1759993
relation: main_file
success: 1
file_date_updated: 2023-08-01T06:40:35Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '27'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: eadg6983
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: WUSCHEL-RELATED HOMEOBOX 13 suppresses de novo shoot regeneration via cell
fate control of pluripotent callus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2023'
...
---
_id: '13992'
abstract:
- lang: eng
text: Understanding the chirality of molecular reaction pathways is essential for
a broad range of fundamental and applied sciences. However, the current ability
to probe chirality on the time scale of primary processes underlying chemical
reactions remains very limited. Here, we demonstrate time-resolved photoelectron
circular dichroism (TRPECD) with ultrashort circularly polarized vacuum-ultraviolet
(VUV) pulses from a tabletop source. We demonstrate the capabilities of VUV-TRPECD
by resolving the chirality changes in time during the photodissociation of atomic
iodine from two chiral molecules. We identify several general key features of
TRPECD, which include the ability to probe dynamical chirality along the complete
photochemical reaction path, the sensitivity to the local chirality of the evolving
scattering potential, and the influence of electron scattering off dissociating
photofragments. Our results are interpreted by comparison with high-level ab-initio
calculations of transient PECDs from molecular photoionization calculations. Our
experimental and theoretical techniques define a general approach to femtochirality.
article_number: abq2811
article_processing_charge: No
article_type: original
arxiv: 1
author:
- first_name: Vít
full_name: Svoboda, Vít
last_name: Svoboda
- first_name: Niraghatam Bhargava
full_name: Ram, Niraghatam Bhargava
last_name: Ram
- first_name: Denitsa Rangelova
full_name: Baykusheva, Denitsa Rangelova
id: 71b4d059-2a03-11ee-914d-dfa3beed6530
last_name: Baykusheva
- first_name: Daniel
full_name: Zindel, Daniel
last_name: Zindel
- first_name: Max D. J.
full_name: Waters, Max D. J.
last_name: Waters
- first_name: Benjamin
full_name: Spenger, Benjamin
last_name: Spenger
- first_name: Manuel
full_name: Ochsner, Manuel
last_name: Ochsner
- first_name: Holger
full_name: Herburger, Holger
last_name: Herburger
- first_name: Jürgen
full_name: Stohner, Jürgen
last_name: Stohner
- first_name: Hans Jakob
full_name: Wörner, Hans Jakob
last_name: Wörner
citation:
ama: Svoboda V, Ram NB, Baykusheva DR, et al. Femtosecond photoelectron circular
dichroism of chemical reactions. Science Advances. 2022;8(28). doi:10.1126/sciadv.abq2811
apa: Svoboda, V., Ram, N. B., Baykusheva, D. R., Zindel, D., Waters, M. D. J., Spenger,
B., … Wörner, H. J. (2022). Femtosecond photoelectron circular dichroism of chemical
reactions. Science Advances. American Association for the Advancement of
Science. https://doi.org/10.1126/sciadv.abq2811
chicago: Svoboda, Vít, Niraghatam Bhargava Ram, Denitsa Rangelova Baykusheva, Daniel
Zindel, Max D. J. Waters, Benjamin Spenger, Manuel Ochsner, Holger Herburger,
Jürgen Stohner, and Hans Jakob Wörner. “Femtosecond Photoelectron Circular Dichroism
of Chemical Reactions.” Science Advances. American Association for the
Advancement of Science, 2022. https://doi.org/10.1126/sciadv.abq2811.
ieee: V. Svoboda et al., “Femtosecond photoelectron circular dichroism of
chemical reactions,” Science Advances, vol. 8, no. 28. American Association
for the Advancement of Science, 2022.
ista: Svoboda V, Ram NB, Baykusheva DR, Zindel D, Waters MDJ, Spenger B, Ochsner
M, Herburger H, Stohner J, Wörner HJ. 2022. Femtosecond photoelectron circular
dichroism of chemical reactions. Science Advances. 8(28), abq2811.
mla: Svoboda, Vít, et al. “Femtosecond Photoelectron Circular Dichroism of Chemical
Reactions.” Science Advances, vol. 8, no. 28, abq2811, American Association
for the Advancement of Science, 2022, doi:10.1126/sciadv.abq2811.
short: V. Svoboda, N.B. Ram, D.R. Baykusheva, D. Zindel, M.D.J. Waters, B. Spenger,
M. Ochsner, H. Herburger, J. Stohner, H.J. Wörner, Science Advances 8 (2022).
date_created: 2023-08-09T13:08:04Z
date_published: 2022-07-15T00:00:00Z
date_updated: 2023-08-22T07:24:01Z
day: '15'
doi: 10.1126/sciadv.abq2811
extern: '1'
external_id:
arxiv:
- '2206.04099'
pmid:
- '35857523'
intvolume: ' 8'
issue: '28'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1126/sciadv.abq2811
month: '07'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Femtosecond photoelectron circular dichroism of chemical reactions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2022'
...
---
_id: '13995'
abstract:
- lang: eng
text: Shape resonances play a central role in many areas of science, but the real-time
measurement of the associated many-body dynamics remains challenging. Here, we
present measurements of recoil frame angle-resolved photoionization delays in
the vicinity of shape resonances of CF4. This technique provides insights into
the spatiotemporal photoionization dynamics of molecular shape resonances. We
find delays of up to ∼600 as in the ionization out of the highest occupied molecular
orbital (HOMO) with a strong dependence on the emission direction and a pronounced
asymmetry along the dissociation axis. Comparison with quantum-scattering calculations
traces the asymmetries to the interference of a small subset of partial waves
at low kinetic energies and, additionally, to the interference of two overlapping
shape resonances in the HOMO-1 channel. Our experimental and theoretical results
establish a broadly applicable approach to space- and time-resolved photoionization
dynamics in the molecular frame.
article_number: abj8121
article_processing_charge: No
article_type: original
author:
- first_name: Saijoscha
full_name: Heck, Saijoscha
last_name: Heck
- first_name: Denitsa Rangelova
full_name: Baykusheva, Denitsa Rangelova
id: 71b4d059-2a03-11ee-914d-dfa3beed6530
last_name: Baykusheva
- first_name: Meng
full_name: Han, Meng
last_name: Han
- first_name: Jia-Bao
full_name: Ji, Jia-Bao
last_name: Ji
- first_name: Conaill
full_name: Perry, Conaill
last_name: Perry
- first_name: Xiaochun
full_name: Gong, Xiaochun
last_name: Gong
- first_name: Hans Jakob
full_name: Wörner, Hans Jakob
last_name: Wörner
citation:
ama: Heck S, Baykusheva DR, Han M, et al. Attosecond interferometry of shape resonances
in the recoil frame of CF4. Science Advances. 2021;7(49). doi:10.1126/sciadv.abj8121
apa: Heck, S., Baykusheva, D. R., Han, M., Ji, J.-B., Perry, C., Gong, X., &
Wörner, H. J. (2021). Attosecond interferometry of shape resonances in the recoil
frame of CF4. Science Advances. American Association for the Advancement
of Science. https://doi.org/10.1126/sciadv.abj8121
chicago: Heck, Saijoscha, Denitsa Rangelova Baykusheva, Meng Han, Jia-Bao Ji, Conaill
Perry, Xiaochun Gong, and Hans Jakob Wörner. “Attosecond Interferometry of Shape
Resonances in the Recoil Frame of CF4.” Science Advances. American Association
for the Advancement of Science, 2021. https://doi.org/10.1126/sciadv.abj8121.
ieee: S. Heck et al., “Attosecond interferometry of shape resonances in the
recoil frame of CF4,” Science Advances, vol. 7, no. 49. American Association
for the Advancement of Science, 2021.
ista: Heck S, Baykusheva DR, Han M, Ji J-B, Perry C, Gong X, Wörner HJ. 2021. Attosecond
interferometry of shape resonances in the recoil frame of CF4. Science Advances.
7(49), abj8121.
mla: Heck, Saijoscha, et al. “Attosecond Interferometry of Shape Resonances in the
Recoil Frame of CF4.” Science Advances, vol. 7, no. 49, abj8121, American
Association for the Advancement of Science, 2021, doi:10.1126/sciadv.abj8121.
short: S. Heck, D.R. Baykusheva, M. Han, J.-B. Ji, C. Perry, X. Gong, H.J. Wörner,
Science Advances 7 (2021).
date_created: 2023-08-09T13:09:02Z
date_published: 2021-12-03T00:00:00Z
date_updated: 2024-10-14T12:23:37Z
day: '03'
doi: 10.1126/sciadv.abj8121
extern: '1'
external_id:
pmid:
- '34860540'
intvolume: ' 7'
issue: '49'
keyword:
- Multidisciplinary
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1126/sciadv.abj8121
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Attosecond interferometry of shape resonances in the recoil frame of CF4
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2021'
...