@article{15358, abstract = {We consider how a population of N haploid individuals responds to directional selection on standing variation, with no new variation from recombination or mutation. Individuals have trait values z1,…,zN, which are drawn from a distribution ψ; the fitness of individual i is proportional to [Formula: see text] . For illustration, we consider the Laplace and Gaussian distributions, which are parametrised only by the variance V0, and show that for large N, there is a scaling limit which depends on a single parameter NV0. When selection is weak relative to drift (NV0≪1), the variance decreases exponentially at rate 1/N, and the expected ultimate gain in log fitness (scaled by V0), is just NV0, which is the same as Robertson's (1960) prediction for a sexual population. In contrast, when selection is strong relative to drift (NV0≫1), the ultimate gain can be found by approximating the establishment of alleles by a branching process in which each allele competes independently with the population mean and the fittest allele to establish is certain to fix. Then, if the probability of survival to time t∼1/V0 of an allele with value z is P(z), with mean P¯, the winning allele is the fittest of NP¯ survivors drawn from a distribution ψP/P¯. The expected ultimate change is ∼2log(1.15NV0) for a Gaussian distribution, and ∼-12log0.36NV0-log-log0.36NV0 for a Laplace distribution. This approach also predicts the variability of the process, and its dynamics; we show that in the strong selection regime, the expected genetic variance decreases as ∼t-3 at large times. We discuss how these results may be related to selection on standing variation that is spread along a linear chromosome.}, author = {Barton, Nicholas H and Sachdeva, Himani}, issn = {1096-0325}, journal = {Theoretical Population Biology}, pages = {129--137}, publisher = {Elsevier}, title = {{Limits to selection on standing variation in an asexual population}}, doi = {10.1016/j.tpb.2024.04.001}, volume = {157}, year = {2024}, } @article{15360, abstract = {We investigate superradiant enhancements in the refrigeration performance of a set of N three-level systems that are collectively coupled to a hot and a cold thermal reservoir and are additionally subject to collective periodic (circular) driving. Assuming the system-reservoir coupling to be weak, we explore the regime of stronger periodic driving strengths by comparing collective weak driving, Floquet-Lindblad, and Floquet-Redfield master equations. We identify regimes where the power injected by the periodic driving is used to pump heat from the cold to the hot reservoir and derive analytic sufficient conditions for them based on a cycle analysis of the Floquet-Lindblad master equation. In those regimes, we also argue for which parameters collective enhancements like a quadratic scaling of the cooling current with N can be expected and support our arguments by numerical simulations.}, author = {Kolisnyk, Dmytro and Queißer, Friedemann and Schaller, Gernot and Schützhold, Ralf}, issn = {2331-7019}, journal = {Physical Review Applied}, number = {4}, publisher = {American Physical Society}, title = {{Floquet analysis of a superradiant many-qutrit refrigerator}}, doi = {10.1103/PhysRevApplied.21.044050}, volume = {21}, year = {2024}, } @inbook{15361, abstract = {Bimolecular fluorescence complementation (BiFC) is a powerful tool for studying protein-protein interactions in living cells. By fusing interacting proteins to fluorescent protein fragments, BiFC allows visualization of spatial localization patterns of protein complexes. This method has been adapted to a variety of expression systems in different organisms and is widely used to study protein interactions in plant cells. The Agrobacterium-mediated transient expression protocol for BiFC assays in Nicotiana benthamiana (N. benthamiana) leaf cells is widely used, but in this chapter, a method for BiFC assay using Arabidopsis thaliana protoplasts is presented.}, author = {Jayasree, Aswathy and Salava, Hymavathi and Nodzynski, Tomasz and Sravankumar, Thula}, booktitle = {Plant Functional Genomics}, editor = {Maghuly, Fatemeh}, isbn = {9781071637777}, issn = {1940-6029}, pages = {305--313}, publisher = {Springer Nature}, title = {{Protein-Protein Interactions Visualized by Bimolecular Fluorescence Complementation in Arabidopsis thaliana Protoplasts from Leaf}}, doi = {10.1007/978-1-0716-3778-4_21}, volume = {2787}, year = {2024}, } @article{15362, abstract = {Constitutional heterozygous pathogenic variants in the exonuclease domain of POLE and POLD1, which affect the proofreading activity of the corresponding polymerases, cause a cancer predisposition syndrome characterized by increased risk of gastrointestinal polyposis, colorectal cancer, endometrial cancer and other tumor types. The generally accepted explanation for the connection between the disruption of the proofreading activity of polymerases epsilon and delta and cancer development is through an increase in the somatic mutation rate. Here we studied an extended family with multiple members heterozygous for the pathogenic POLD1 variant c.1421T>C p.(Leu474Pro), which segregates with the polyposis and cancer phenotypes. Through the analysis of mutational patterns of patient-derived fibroblasts colonies and de novo mutations obtained by parent-offspring comparisons, we concluded that heterozygous POLD1 L474P just subtly increases the somatic and germline mutation burden. In contrast, tumors developed in individuals with a heterozygous mutation in the exonuclease domain of POLD1, including L474P, have an extremely high mutation rate (>100 mut/Mb) associated with signature SBS10d. We solved this contradiction through the observation that tumorigenesis involves somatic inactivation of the wildtype POLD1 allele. These results imply that exonuclease deficiency of polymerase delta has a recessive effect on mutation rate.}, author = {Andrianova, Maria A. and Seplyarskiy, Vladimir B. and Terradas, Mariona and Sánchez-Heras, Ana Beatriz and Mur, Pilar and Soto, José Luis and Aiza, Gemma and Borràs, Emma and Kondrashov, Fyodor and Kondrashov, Alexey S. and Bazykin, Georgii A. and Valle, Laura}, issn = {1476-5438}, journal = {European Journal of Human Genetics}, pages = {837--845}, publisher = {Springer Nature}, title = {{Discovery of recessive effect of human polymerase δ proofreading deficiency through mutational analysis of POLD1-mutated normal and cancer cells}}, doi = {10.1038/s41431-024-01598-8}, volume = {32}, year = {2024}, } @article{15367, abstract = {Two-dimensional semiconductor-superconductor heterostructures form the foundation of numerous nanoscale physical systems. However, measuring the properties of such heterostructures, and characterizing the semiconductor in-situ is challenging. A recent experimental study by [Phys. Rev. Lett. 128, 107701 (2022)] was able to probe the semiconductor within the heterostructure using microwave measurements of the superfluid density. This work revealed a rapid depletion of superfluid density in semiconductor, caused by the in-plane magnetic field which in presence of spin-orbit coupling creates so-called Bogoliubov Fermi surfaces. The experimental work used a simplified theoretical model that neglected the presence of non-magnetic disorder in the semiconductor, hence describing the data only qualitatively. Motivated by experiments, we introduce a theoretical model describing a disordered semiconductor with strong spin-orbit coupling that is proximitized by a superconductor. Our model provides specific predictions for the density of states and superfluid density. Presence of disorder leads to the emergence of a gapless superconducting phase, that may be viewed as a manifestation of Bogoliubov Fermi surface. When applied to real experimental data, our model showcases excellent quantitative agreement, enabling the extraction of material parameters such as mean free path and mobility, and estimating g-tensor after taking into account the orbital contribution of magnetic field. Our model can be used to probe in-situ parameters of other superconductor-semiconductor heterostructures and can be further extended to give access to transport properties.}, author = {Babkin, Serafim and Higginbotham, Andrew P and Serbyn, Maksym}, issn = {2542-4653}, journal = {SciPost Physics}, number = {5}, publisher = {SciPost Foundation}, title = {{Proximity-induced gapless superconductivity in two-dimensional Rashba semiconductor in magnetic field}}, doi = {10.21468/scipostphys.16.5.115}, volume = {16}, year = {2024}, } @article{15372, abstract = {CRISPR-Cas9 is a powerful tool for genome editing, but the strict requirement for an NGG protospacer-adjacent motif (PAM) sequence immediately next to the DNA target limits the number of editable genes. Recently developed Cas9 variants have been engineered with relaxed PAM requirements, including SpG-Cas9 (SpG) and the nearly PAM-less SpRY-Cas9 (SpRY). However, the molecular mechanisms of how SpRY recognizes all potential PAM sequences remains unclear. Here, we combine structural and biochemical approaches to determine how SpRY interrogates DNA and recognizes target sites. Divergent PAM sequences can be accommodated through conformational flexibility within the PAM-interacting region, which facilitates tight binding to off-target DNA sequences. Nuclease activation occurs ~1000-fold slower than for Streptococcus pyogenes Cas9, enabling us to directly visualize multiple on-pathway intermediate states. Experiments with SpG position it as an intermediate enzyme between Cas9 and SpRY. Our findings shed light on the molecular mechanisms of PAMless genome editing.}, author = {Hibshman, Grace N. and Bravo, Jack Peter Kelly and Hooper, Matthew M. and Dangerfield, Tyler L. and Zhang, Hongshan and Finkelstein, Ilya J. and Johnson, Kenneth A. and Taylor, David W.}, issn = {2041-1723}, journal = {Nature Communications}, publisher = {Springer Nature}, title = {{Unraveling the mechanisms of PAMless DNA interrogation by SpRY-Cas9}}, doi = {10.1038/s41467-024-47830-3}, volume = {15}, year = {2024}, } @article{15373, abstract = {In this article we prove a refined version of the Christensen–Evans theorem for generators of uniformly continuous GNS-symmetric quantum Markov semigroups. We use this result to show the existence of GNS-symmetric extensions of GNS-symmetric quantum Markov semigroups. In particular, this implies that the generators of GNS-symmetric quantum Markov semigroups on finite-dimensional von Neumann algebra can be written in the form specified by Alicki's theorem.}, author = {Wirth, Melchior}, issn = {1096-0783}, journal = {Journal of Functional Analysis}, number = {3}, publisher = {Elsevier}, title = {{Christensen–Evans theorem and extensions of GNS-symmetric quantum Markov semigroups}}, doi = {10.1016/j.jfa.2024.110475}, volume = {287}, year = {2024}, } @article{15374, abstract = {Clathrin-mediated endocytosis (CME) is an essential process of cargo uptake operating in all eukaryotes. In animals and yeast, BAR-SH3 domain proteins, endophilins and amphiphysins, function at the conclusion of CME to recruit factors for vesicle scission and uncoating. Arabidopsis thaliana contains the BAR-SH3 domain proteins SH3P1–SH3P3, but their role is poorly understood. Here, we identify SH3Ps as functional homologs of endophilin/amphiphysin. SH3P1–SH3P3 bind to discrete foci at the plasma membrane (PM), and SH3P2 recruits late to a subset of clathrin-coated pits. The SH3P2 PM recruitment pattern is nearly identical to its interactor, a putative uncoating factor, AUXILIN-LIKE1. Notably, SH3P1–SH3P3 are required for most of AUXILIN-LIKE1 recruitment to the PM. This indicates a plant-specific modification of CME, where BAR-SH3 proteins recruit auxilin-like uncoating factors rather than the uncoating phosphatases, synaptojanins. SH3P1–SH3P3 act redundantly in overall CME with the plant-specific endocytic adaptor TPLATE complex but not due to an SH3 domain in its TASH3 subunit.}, author = {Adamowski, Maciek and Randuch, Marek and Matijevic, Ivana and Narasimhan, Madhumitha and Friml, Jiří}, issn = {2211-1247}, journal = {Cell Reports}, number = {5}, publisher = {Cell Press}, title = {{SH3Ps recruit auxilin-like vesicle uncoating factors for clathrin-mediated endocytosis}}, doi = {10.1016/j.celrep.2024.114195}, volume = {43}, year = {2024}, } @article{15375, abstract = {In the eukaryotic nucleus, heterochromatin forms highly condensed, visible foci known as heterochromatin foci (HF). These HF are enriched with linker histone H1, a key player in heterochromatin condensation and silencing. However, it is unknown how H1 aggregates HF and condenses heterochromatin. In this study, we established that H1 facilitates heterochromatin condensation by enhancing inter- and intrachromosomal interactions between and within heterochromatic regions of the Arabidopsis (Arabidopsis thaliana) genome. We demonstrated that H1 drives HF formation via phase separation, which requires its C-terminal intrinsically disordered region (C-IDR). A truncated H1 lacking the C-IDR fails to form foci or recover HF in the h1 mutant background, whereas C-IDR with a short stretch of the globular domain (18 out of 71 amino acids) is sufficient to rescue both defects. In addition, C-IDR is essential for H1's roles in regulating nucleosome repeat length and DNA methylation in Arabidopsis, indicating that phase separation capability is required for chromatin functions of H1. Our data suggest that bacterial H1-like proteins, which have been shown to condense DNA, are intrinsically disordered and capable of mediating phase separation. Therefore, we propose that phase separation mediated by H1 or H1-like proteins may represent an ancient mechanism for condensing chromatin and DNA.}, author = {He, Shengbo and Yu, Yiming and Wang, Liang and Zhang, Jingyi and Bai, Zhengyong and Li, Guohong and Li, Pilong and Feng, Xiaoqi}, issn = {1532-298X}, journal = {The Plant Cell}, number = {5}, pages = {1829--1843}, publisher = {Oxford University Press}, title = {{Linker histone H1 drives heterochromatin condensation via phase separation in Arabidopsis}}, doi = {10.1093/plcell/koae034}, volume = {36}, year = {2024}, } @inproceedings{15376, abstract = {Sequential decision-making tasks often require satisfaction of multiple, partially-contradictory objectives. Existing approaches are monolithic, where a single policy fulfills all objectives. We present auction-based scheduling, a decentralized framework for multi-objective sequential decision making. Each objective is fulfilled using a separate and independent policy. Composition of policies is performed at runtime, where at each step, the policies simultaneously bid from pre-allocated budgets for the privilege of choosing the next action. The framework allows policies to be independently created, modified, and replaced. We study path planning problems on finite graphs with two temporal objectives and present algorithms to synthesize policies together with bidding policies in a decentralized manner. We consider three categories of decentralized synthesis problems, parameterized by the assumptions that the policies make on each other. We identify a class of assumptions called assume-admissible for which synthesis is always possible for graphs whose every vertex has at most two outgoing edges.}, author = {Avni, Guy and Mallik, Kaushik and Sadhukhan, Suman}, booktitle = {30th International Conference on Tools and Algorithms for the Construction and Analysis of Systems}, isbn = {9783031572555}, issn = {1611-3349}, location = {Luxembourg City, Luxembourg}, pages = {153--172}, publisher = {Springer Nature}, title = {{Auction-based scheduling}}, doi = {10.1007/978-3-031-57256-2_8}, volume = {14572}, year = {2024}, } @inproceedings{15377, abstract = {We provide an algorithmto solve Rabin and Streett games over graphs with n vertices,m edges, and k colours that runs in ˜O³mn(k!)1+o(1)´time and O(nk logk logn) space, where ˜O hides poly-logarithmic factors. Our algorithm is an improvement by a super quadratic dependence on k! from the currently best known run time of O³mn2(k!)2+o(1)´, obtained by converting a Rabin gameinto a parity game,while simultaneously improving its exponential space requirement. Our main technical ingredient is a characterisation of progress measures for Rabin games using colourful trees and a combinatorial construction of succinctlyrepresented, universal colourful trees. Colourful universal trees are generalisations of universal trees used by Jurdzi´nski and Lazi´c (2017) to solve parity games, as well as of Rabin progress measures of Klarlund and Kozen (1991). Our algorithm for Rabin games is a progress measure lifting algorithm where the lifting is performed on succinct, colourful, universal trees.}, author = {Majumdar, Rupak and Sağlam, Irmak and Thejaswini, K. S.}, booktitle = {30th International Conference on Tools and Algorithms for the Construction and Analysis of Systems}, isbn = {9783031572555}, issn = {1611-3349}, pages = {213--231}, publisher = {Springer Nature}, title = {{Rabin games and colourful universal trees}}, doi = {10.1007/978-3-031-57256-2_11}, volume = {14572}, year = {2024}, } @article{15378, abstract = {We consider N×N non-Hermitian random matrices of the form X+A, where A is a general deterministic matrix and N−−√X consists of independent entries with zero mean, unit variance, and bounded densities. For this ensemble, we prove (i) a Wegner estimate, i.e. that the local density of eigenvalues is bounded by N1+o(1) and (ii) that the expected condition number of any bulk eigenvalue is bounded by N1+o(1); both results are optimal up to the factor No(1). The latter result complements the very recent matching lower bound obtained in [15] (arXiv:2301.03549) and improves the N-dependence of the upper bounds in [5,6,32] (arXiv:1906.11819, arXiv:2005.08930, arXiv:2005.08908). Our main ingredient, a near-optimal lower tail estimate for the small singular values of X+A−z, is of independent interest.}, author = {Erdös, László and Ji, Hong Chang}, issn = {1097-0312}, journal = {Communications on Pure and Applied Mathematics}, number = {9}, pages = {3785--3840}, publisher = {Wiley}, title = {{Wegner estimate and upper bound on the eigenvalue condition number of non-Hermitian random matrices}}, doi = {10.1002/cpa.22201}, volume = {77}, year = {2024}, } @article{15379, abstract = {Long-term potentiation (LTP) of excitatory synapses is a leading model to explain the concept of information storage in the brain. Multiple mechanisms contribute to LTP, but central amongst them is an increased sensitivity of the postsynaptic membrane to neurotransmitter release. This sensitivity is predominantly determined by the abundance and localization of AMPA-type glutamate receptors (AMPARs). A combination of AMPAR structural data, super-resolution imaging of excitatory synapses, and an abundance of electrophysiological studies are providing an ever-clearer picture of how AMPARs are recruited and organized at synaptic junctions. Here, we review the latest insights into this process, and discuss how both cytoplasmic and extracellular receptor elements cooperate to tune the AMPAR response at the hippocampal CA1 synapse.}, author = {Stockwell, Imogen and Watson, Jake and Greger, Ingo H.}, issn = {1521-1878}, journal = {BioEssays}, number = {7}, publisher = {Wiley}, title = {{Tuning synaptic strength by regulation of AMPA glutamate receptor localization}}, doi = {10.1002/bies.202400006}, volume = {46}, year = {2024}, } @article{15380, abstract = {The depth of a cell in an arrangement of n (non-vertical) great-spheres in Sd is the number of great-spheres that pass above the cell. We prove Euler-type relations, which imply extensions of the classic Dehn–Sommerville relations for convex polytopes to sublevel sets of the depth function, and we use the relations to extend the expressions for the number of faces of neighborly polytopes to the number of cells of levels in neighborly arrangements.}, author = {Biswas, Ranita and Cultrera Di Montesano, Sebastiano and Edelsbrunner, Herbert and Saghafian, Morteza}, issn = {2367-1734}, journal = {Journal of Applied and Computational Topology}, pages = {557--578}, publisher = {Springer Nature}, title = {{Depth in arrangements: Dehn–Sommerville–Euler relations with applications}}, doi = {10.1007/s41468-024-00173-w}, volume = {8}, year = {2024}, } @article{15381, abstract = {Cholecystokinin-expressing interneurons (CCKIs) are hypothesized to shape pyramidal cell-firing patterns and regulate network oscillations and related network state transitions. To directly probe their role in the CA1 region, we silenced their activity using optogenetic and chemogenetic tools in mice. Opto-tagged CCKIs revealed a heterogeneous population, and their optogenetic silencing triggered wide disinhibitory network changes affecting both pyramidal cells and other interneurons. CCKI silencing enhanced pyramidal cell burst firing and altered the temporal coding of place cells: theta phase precession was disrupted, whereas sequence reactivation was enhanced. Chemogenetic CCKI silencing did not alter the acquisition of spatial reference memories on the Morris water maze but enhanced the recall of contextual fear memories and enabled selective recall when similar environments were tested. This work suggests the key involvement of CCKIs in the control of place-cell temporal coding and the formation of contextual memories.}, author = {Rangel Guerrero, Dámaris K and Balueva, Kira and Barayeu, Uladzislau and Baracskay, Peter and Gridchyn, Igor and Nardin, Michele and Roth, Chiara N and Wulff, Peer and Csicsvari, Jozsef L}, issn = {1097-4199}, journal = {Neuron}, number = {12}, pages = {2045--2061.e10}, publisher = {Cell Press}, title = {{Hippocampal cholecystokinin-expressing interneurons regulate temporal coding and contextual learning}}, doi = {10.1016/j.neuron.2024.03.019}, volume = {112}, year = {2024}, } @misc{15385, abstract = {Relevant information about the data can be found in the 'Readme_Data.txt' file. A previous version of the publication can be found on BioRxiv: https://www.biorxiv.org/content/10.1101/2022.10.11.511691v4 and published in Plos Biology (2024)}, author = {Burnett, Laura and Koppensteiner, Peter and Symonova, Olga and Masson, Tomas and Vega Zuniga, Tomas A and Contreras, Ximena and Rülicke, Thomas and Shigemoto, Ryuichi and Novarino, Gaia and Jösch, Maximilian A}, keywords = {ASD, periaqueductal gray, perception, behavior, potassium channels}, publisher = {Institute of Science and Technology Austria}, title = {{Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice}}, doi = {10.15479/AT:ISTA:15385}, year = {2024}, } @article{15404, abstract = {We used diverse methods to characterize the role of avian lateral spiriform nucleus (SpL) in basal ganglia motor function. Connectivity analysis showed that SpL receives input from globus pallidus (GP), and the intrapeduncular nucleus (INP) located ventromedial to GP, whose neurons express numerous striatal markers. SpL-projecting GP neurons were large and aspiny, while SpL-projecting INP neurons were medium sized and spiny. Connectivity analysis further showed that SpL receives inputs from subthalamic nucleus (STN) and substantia nigra pars reticulata (SNr), and that the SNr also receives inputs from GP, INP, and STN. Neurochemical analysis showed that SpL neurons express ENK, GAD, and a variety of pallidal neuron markers, and receive GABAergic terminals, some of which also contain DARPP32, consistent with GP pallidal and INP striatal inputs. Connectivity and neurochemical analysis showed that the SpL input to tectum prominently ends on GABAA receptor-enriched tectobulbar neurons. Behavioral studies showed that lesions of SpL impair visuomotor behaviors involving tracking and pecking moving targets. Our results suggest that SpL modulates brainstem-projecting tectobulbar neurons in a manner comparable to the demonstrated influence of GP internus on motor thalamus and of SNr on tectobulbar neurons in mammals. Given published data in amphibians and reptiles, it seems likely the SpL circuit represents a major direct pathway-type circuit by which the basal ganglia exerts its motor influence in nonmammalian tetrapods. The present studies also show that avian striatum is divided into three spatially segregated territories with differing connectivity, a medial striato-nigral territory, a dorsolateral striato-GP territory, and the ventrolateral INP motor territory.}, author = {Reiner, Anton and Medina, Loreta and Abellan, Antonio and Deng, Yunping and Toledo, Claudio A.B. and Luksch, Harald and Vega Zuniga, Tomas A and Riley, Nell B. and Hodos, William and Karten, Harvey J.}, issn = {1096-9861}, journal = {Journal of Comparative Neurology}, number = {5}, publisher = {Wiley}, title = {{Neurochemistry and circuit organization of the lateral spiriform nucleus of birds: A uniquely nonmammalian direct pathway component of the basal ganglia}}, doi = {10.1002/cne.25620}, volume = {532}, year = {2024}, } @article{15405, abstract = {We report JWST/NIRCam measurements of quasar host galaxy emissions and supermassive black hole (SMBH) masses for six quasars at 5.9 < z < 7.1 in the Emission-line galaxies and Intergalactic Gas in the Epoch of Reionization (EIGER) project. We obtain deep NIRCam imaging in the F115W, F200W, and F356W bands, as well as F356W grism spectroscopy of the quasars. We use bright unsaturated stars to construct models of the point-spread functions (PSFs) and estimate the errors of these PSFs. We then measure or constrain the fluxes and morphology of the quasar host galaxies by fitting the quasar images as a point source plus an exponential disk. We successfully detect the host galaxies of three quasars, which have host-to-quasar-flux ratios of ∼1%–5%. Spectral energy distribution fitting suggests that these quasar host galaxies have stellar masses of M* ≳ 1010M⊙. For quasars with host galaxy nondetections, we estimate the upper limits of their stellar masses. We use the grism spectra to measure the Hβ line profile and the continuum luminosity, then estimate the SMBH masses for the quasars. Our results indicate that the positive relation between SMBH masses and host galaxy stellar masses already exists at redshift z ≳ 6. The quasars in our sample show a high BH-to-stellar-mass ratio of MBH/M* ∼ 0.15, which is about ∼2 dex higher than local relations. We find that selection effects only contribute partially to the high MBH/M* ratios of high-redshift quasars. This result hints at a possible redshift evolution of the MBH–M* relation.}, author = {Yue, Minghao and Eilers, Anna Christina and Simcoe, Robert A. and Mackenzie, Ruari and Matthee, Jorryt J and Kashino, Daichi and Bordoloi, Rongmon and Lilly, Simon J. and Naidu, Rohan P.}, issn = {1538-4357}, journal = {Astrophysical Journal}, number = {2}, publisher = {IOP Publishing}, title = {{EIGER. V. Characterizing the host galaxies of luminous quasars at z ≳ 6}}, doi = {10.3847/1538-4357/ad3914}, volume = {966}, year = {2024}, } @article{15406, abstract = {We report on dynamic Shubnikov–de Haas (SdH) oscillations that are measured in the optical response, subterahertz transmittance of two-dimensional systems, and reveal two distinct types of oscillation nodes: “universal” nodes at integer ratios of radiation and cyclotron frequencies and “tunable” nodes at positions sensitive to all parameters of the structure. The nodes in both real and imaginary parts of the measured complex transmittance are analyzed using a dynamic version of the static Lifshitz-Kosevich formula. These results demonstrate that the node structure of the dynamic SdH oscillations provides an all-optical access to quantization- and interaction-induced renormalization effects, in addition to parameters one can obtain from the static SdH oscillations.}, author = {Savchenko, M. L. and Gospodarič, J. and Shuvaev, A. and Dmitriev, I. A. and Dziom, Vlad and Dobretsova, A. A. and Mikhailov, N. N. and Kvon, Z. D. and Pimenov, A.}, issn = {2643-1564}, journal = {Physical Review Research}, number = {2}, publisher = {American Physical Society}, title = {{Optical Shubnikov-de Haas oscillations in two-dimensional electron systems}}, doi = {10.1103/PhysRevResearch.6.L022027}, volume = {6}, year = {2024}, } @article{15407, abstract = {We propose and implement a family of quantum-informed recursive optimization (QIRO) algorithms for combinatorial optimization problems. Our approach leverages quantum resources to obtain information that is used in problem-specific classical reduction steps that recursively simplify the problem. These reduction steps address the limitations of the quantum component (e.g., locality) and ensure solution feasibility in constrained optimization problems. Additionally, we use backtracking techniques to further improve the performance of the algorithm without increasing the requirements on the quantum hardware. We showcase the capabilities of our approach by informing QIRO with correlations from classical simulations of shallow circuits of the quantum approximate optimization algorithm, solving instances of maximum independent set and maximum satisfiability problems with hundreds of variables. We also demonstrate how QIRO can be deployed on a neutral atom quantum processor to find large independent sets of graphs. In summary, our scheme achieves results comparable to classical heuristics even with relatively weak quantum resources. Furthermore, enhancing the quality of these quantum resources improves the performance of the algorithms. Notably, the modular nature of QIRO offers various avenues for modifications, positioning our work as a template for a broader class of hybrid quantum-classical algorithms for combinatorial optimization.}, author = {Finžgar, Jernej Rudi and Kerschbaumer, Aron and Schuetz, Martin J.A. and Mendl, Christian B. and Katzgraber, Helmut G.}, issn = {2691-3399}, journal = {PRX Quantum}, number = {2}, publisher = {American Physical Society}, title = {{Quantum-informed recursive optimization algorithms}}, doi = {10.1103/PRXQuantum.5.020327}, volume = {5}, year = {2024}, }