[{"citation":{"chicago":"Weyer, Yannick, Sinead I. Schwabl, Xuechen Tang, Astha Purwar, Konstantin Siegmann, Angela Ruepp, Theresia Dunzendorfer-Matt, et al. “The Dsc Ubiquitin Ligase Complex Identifies Transmembrane Degrons to Degrade Orphaned Proteins at the Golgi.” <i>Nature Communications</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41467-024-53676-6\">https://doi.org/10.1038/s41467-024-53676-6</a>.","mla":"Weyer, Yannick, et al. “The Dsc Ubiquitin Ligase Complex Identifies Transmembrane Degrons to Degrade Orphaned Proteins at the Golgi.” <i>Nature Communications</i>, vol. 15, 9257, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s41467-024-53676-6\">10.1038/s41467-024-53676-6</a>.","short":"Y. Weyer, S.I. Schwabl, X. Tang, A. Purwar, K. Siegmann, A. Ruepp, T. Dunzendorfer-Matt, M.A. Widerin, V. Niedrist, N.J.M. Mutsters, M.G. Tettamanti, S. Weys, B. Sarg, L. Kremser, K.R. Liedl, O. Schmidt, D. Teis, Nature Communications 15 (2024).","apa":"Weyer, Y., Schwabl, S. I., Tang, X., Purwar, A., Siegmann, K., Ruepp, A., … Teis, D. (2024). The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-024-53676-6\">https://doi.org/10.1038/s41467-024-53676-6</a>","ista":"Weyer Y, Schwabl SI, Tang X, Purwar A, Siegmann K, Ruepp A, Dunzendorfer-Matt T, Widerin MA, Niedrist V, Mutsters NJM, Tettamanti MG, Weys S, Sarg B, Kremser L, Liedl KR, Schmidt O, Teis D. 2024. The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. Nature Communications. 15, 9257.","ieee":"Y. Weyer <i>et al.</i>, “The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi,” <i>Nature Communications</i>, vol. 15. Springer Nature, 2024.","ama":"Weyer Y, Schwabl SI, Tang X, et al. The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi. <i>Nature Communications</i>. 2024;15. doi:<a href=\"https://doi.org/10.1038/s41467-024-53676-6\">10.1038/s41467-024-53676-6</a>"},"article_type":"original","DOAJ_listed":"1","language":[{"iso":"eng"}],"oa_version":"Published Version","scopus_import":"1","publication":"Nature Communications","date_created":"2024-11-10T23:01:58Z","type":"journal_article","abstract":[{"lang":"eng","text":"The Golgi apparatus is essential for protein sorting, yet its quality control mechanisms are poorly understood. Here we show that the Dsc ubiquitin ligase complex uses its rhomboid pseudo-protease subunit, Dsc2, to assess the hydrophobic length of α-helical transmembrane domains (TMDs) at the Golgi. Thereby the Dsc complex likely interacts with orphaned ER and Golgi proteins that have shorter TMDs and ubiquitinates them for targeted degradation. Some Dsc substrates will be extracted by Cdc48 for endosome and Golgi associated proteasomal degradation (EGAD), while others will undergo ESCRT dependent vacuolar degradation. Some substrates are degraded by both, EGAD- or ESCRT pathways. The accumulation of Dsc substrates entails a specific increase in glycerophospholipids with shorter and asymmetric fatty acyl chains. Hence, the Dsc complex mediates the selective degradation of orphaned proteins at the sorting center of cells, which prevents their spreading across other organelles and thereby preserves cellular membrane protein and lipid composition."}],"status":"public","external_id":{"pmid":["39461958"],"isi":["001345548100007"]},"has_accepted_license":"1","OA_type":"gold","OA_place":"publisher","intvolume":"        15","date_updated":"2026-03-05T11:20:12Z","ddc":["570"],"pmid":1,"author":[{"full_name":"Weyer, Yannick","last_name":"Weyer","first_name":"Yannick"},{"first_name":"Sinead I.","last_name":"Schwabl","full_name":"Schwabl, Sinead I."},{"first_name":"Xuechen","last_name":"Tang","full_name":"Tang, Xuechen"},{"last_name":"Purwar","first_name":"Astha","full_name":"Purwar, Astha"},{"full_name":"Siegmann, Konstantin","first_name":"Konstantin","last_name":"Siegmann"},{"full_name":"Ruepp, Angela","first_name":"Angela","last_name":"Ruepp"},{"full_name":"Dunzendorfer-Matt, Theresia","first_name":"Theresia","last_name":"Dunzendorfer-Matt"},{"last_name":"Widerin","first_name":"Michael A.","full_name":"Widerin, Michael A."},{"last_name":"Niedrist","first_name":"Veronika","full_name":"Niedrist, Veronika"},{"full_name":"Mutsters, Noa J.M.","last_name":"Mutsters","first_name":"Noa J.M."},{"last_name":"Tettamanti","first_name":"Maria G.","full_name":"Tettamanti, Maria G."},{"last_name":"Weys","first_name":"Sabine","id":"caffa136-9669-11ed-9092-ceac12ac9c05","full_name":"Weys, Sabine"},{"first_name":"Bettina","last_name":"Sarg","full_name":"Sarg, Bettina"},{"last_name":"Kremser","first_name":"Leopold","full_name":"Kremser, Leopold"},{"first_name":"Klaus R.","last_name":"Liedl","full_name":"Liedl, Klaus R."},{"full_name":"Schmidt, Oliver","last_name":"Schmidt","first_name":"Oliver"},{"full_name":"Teis, David","first_name":"David","last_name":"Teis"}],"volume":15,"month":"12","year":"2024","file_date_updated":"2025-01-22T14:36:33Z","publication_status":"published","date_published":"2024-12-01T00:00:00Z","_id":"18522","quality_controlled":"1","article_number":"9257","isi":1,"doi":"10.1038/s41467-024-53676-6","acknowledgement":"We thank Snezhana Oliferenko, Hesso Farhan, Chris Dunworth, and Lukas A Huber for critically reading the manuscript, Ming Li, Peter Espenshade, Sebastien Leon, and Scott Emr for reagents, Bob Kaufmann for help in characterizing the Dsc2 L1 loop mutant. This research was funded in part by the Austrian Science Fund (FWF) (10.55776/P32161, 10.55776/P34907, 10.55776/DOC82 to DT, and 10.55776/P36187 to OS), by a Lipotype lipidomics excellence award (LEA 2019) to OS, by a Luxembourg National Research Fund (FNR): Grant #13571826 to YW, and by European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No. 847681 (to KRL). For open access purposes, the author has applied a CC BY public copyright license to any author accepted manuscript version arising from this submission.","file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_created":"2025-01-22T14:36:33Z","file_size":5634494,"checksum":"32c986fc3babec999c03a5c043310f40","success":1,"date_updated":"2025-01-22T14:36:33Z","file_name":"2024_NatureComm_Weyer.pdf","file_id":"18870"}],"publisher":"Springer Nature","article_processing_charge":"Yes","publication_identifier":{"eissn":["2041-1723"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"01","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"The Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi"},{"page":"3155-3175","author":[{"full_name":"Pizzati, Elia","first_name":"Elia","last_name":"Pizzati"},{"full_name":"Hennawi, Joseph F.","last_name":"Hennawi","first_name":"Joseph F."},{"full_name":"Schaye, Joop","first_name":"Joop","last_name":"Schaye"},{"first_name":"Matthieu","last_name":"Schaller","full_name":"Schaller, Matthieu"},{"full_name":"Eilers, Anna Christina","last_name":"Eilers","first_name":"Anna Christina"},{"full_name":"Wang, Feige","first_name":"Feige","last_name":"Wang"},{"first_name":"Carlos S.","last_name":"Frenk","full_name":"Frenk, Carlos S."},{"last_name":"Elbers","first_name":"Willem","full_name":"Elbers, Willem"},{"last_name":"Helly","first_name":"John C.","full_name":"Helly, John C."},{"full_name":"Mackenzie, Ruari","first_name":"Ruari","last_name":"Mackenzie"},{"id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","first_name":"Jorryt J","orcid":"0000-0003-2871-127X","last_name":"Matthee"},{"last_name":"Bordoloi","first_name":"Rongmon","full_name":"Bordoloi, Rongmon"},{"first_name":"Daichi","last_name":"Kashino","full_name":"Kashino, Daichi"},{"last_name":"Naidu","first_name":"Rohan P.","full_name":"Naidu, Rohan P."},{"first_name":"Minghao","last_name":"Yue","full_name":"Yue, Minghao"}],"issue":"4","volume":534,"month":"11","year":"2024","file_date_updated":"2024-11-12T07:17:26Z","publication_status":"published","citation":{"ista":"Pizzati E, Hennawi JF, Schaye J, Schaller M, Eilers AC, Wang F, Frenk CS, Elbers W, Helly JC, Mackenzie R, Matthee JJ, Bordoloi R, Kashino D, Naidu RP, Yue M. 2024. A unified model for the clustering of quasars and galaxies at z ≈ 6. Monthly Notices of the Royal Astronomical Society. 534(4), 3155–3175.","ama":"Pizzati E, Hennawi JF, Schaye J, et al. A unified model for the clustering of quasars and galaxies at z ≈ 6. <i>Monthly Notices of the Royal Astronomical Society</i>. 2024;534(4):3155-3175. doi:<a href=\"https://doi.org/10.1093/mnras/stae2307\">10.1093/mnras/stae2307</a>","ieee":"E. Pizzati <i>et al.</i>, “A unified model for the clustering of quasars and galaxies at z ≈ 6,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 534, no. 4. Oxford University Press, pp. 3155–3175, 2024.","apa":"Pizzati, E., Hennawi, J. F., Schaye, J., Schaller, M., Eilers, A. C., Wang, F., … Yue, M. (2024). A unified model for the clustering of quasars and galaxies at z ≈ 6. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stae2307\">https://doi.org/10.1093/mnras/stae2307</a>","short":"E. Pizzati, J.F. Hennawi, J. Schaye, M. Schaller, A.C. Eilers, F. Wang, C.S. Frenk, W. Elbers, J.C. Helly, R. Mackenzie, J.J. Matthee, R. Bordoloi, D. Kashino, R.P. Naidu, M. Yue, Monthly Notices of the Royal Astronomical Society 534 (2024) 3155–3175.","mla":"Pizzati, Elia, et al. “A Unified Model for the Clustering of Quasars and Galaxies at z ≈ 6.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 534, no. 4, Oxford University Press, 2024, pp. 3155–75, doi:<a href=\"https://doi.org/10.1093/mnras/stae2307\">10.1093/mnras/stae2307</a>.","chicago":"Pizzati, Elia, Joseph F. Hennawi, Joop Schaye, Matthieu Schaller, Anna Christina Eilers, Feige Wang, Carlos S. Frenk, et al. “A Unified Model for the Clustering of Quasars and Galaxies at z ≈ 6.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/mnras/stae2307\">https://doi.org/10.1093/mnras/stae2307</a>."},"article_type":"original","DOAJ_listed":"1","language":[{"iso":"eng"}],"date_created":"2024-11-10T23:01:58Z","publication":"Monthly Notices of the Royal Astronomical Society","scopus_import":"1","oa_version":"Published Version","type":"journal_article","abstract":[{"lang":"eng","text":"Recent observations from the EIGER JWST program have measured for the first time the quasar–galaxy cross-correlation function at z ≈ 6. The autocorrelation function of faint z ≈ 6 quasars was also recently estimated. These measurements provide key insights into the properties of quasars and galaxies at high redshift and their relation with the host dark matter haloes. In this work, we interpret these data building upon an empirical quasar population model that has been applied successfully to quasar clustering and demographic measurements at z ≈ 2–4. We use a new, large-volume N-body simulation with more than a trillion particles, FLAMINGO-10k, to model quasars and galaxies simultaneously. We successfully reproduce observations of z ≈ 6 quasars and galaxies (i.e. their clustering properties and luminosity functions), and infer key quantities such as their luminosity–halo mass relation, the mass function of their host haloes, and their duty cycle/occupation fraction. Our key findings\r\nare (i) quasars reside on average in ≈ 1012.5 M haloes (corresponding to ≈ 5σ fluctuations in the initial conditions of the linear density field), but the distribution of host halo masses is quite broad; (ii) the duty cycle of (UV-bright) quasar activity is relatively low (≈ 1 per cent); (iii) galaxies (that are bright in [O III]) live in much smaller haloes (≈ 1010.9 M) and have a larger duty cycle (occupation fraction) of ≈ 13 per cent. Finally, we focus on the inferred properties of quasars and present a homogeneous analysis of their evolution with redshift. The picture that emerges reveals a strong evolution of the host halo mass and duty cycle of quasars at z ≈ 2–6, and calls for new investigations of the role of quasar activity across cosmic time."}],"status":"public","has_accepted_license":"1","external_id":{"isi":["001335663900008"]},"OA_type":"gold","intvolume":"       534","OA_place":"publisher","date_updated":"2025-09-08T14:40:22Z","ddc":["520"],"article_processing_charge":"Yes","publication_identifier":{"issn":["0035-8711"],"eissn":["1365-2966"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"01","department":[{"_id":"JoMa"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"title":"A unified model for the clustering of quasars and galaxies at z ≈ 6","_id":"18523","quality_controlled":"1","date_published":"2024-11-01T00:00:00Z","isi":1,"acknowledgement":"We are grateful to Junya Arita and the SHELLQs team for sharing their data on the quasar autocorrelation function and to Jan-Torge Schindler for discussion on the QLF. We acknowledge helpful conversations with the ENIGMA group at UC Santa Barbara and Leiden University. EP is grateful to Rob McGibbon and Victor Forouhar Moreno for help with the simulation outputs, and to Timo Kist, Jiamu Huang, and Vikram Khaire for comments on an early version of the manuscript. JFH and EP acknowledge support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 885301). This work is partly supported by funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No 860744 (BiD4BESt). FW acknowledges support from NSF grant AST-2308258. This work used the DiRAC Memory Intensive service (Cosma8) at the University of Durham, which is part of the STFC DiRAC HPC Facility (www.dirac.ac.uk). Access to DiRAC resources was granted through a Director’s Discretionary Time allocation in 2023/24, under the auspices of the UKRI-funded\r\nDiRAC Federation Project. The equipment was funded by BEIS capital funding via STFC capital grants ST/K00042X/1, ST/P002293/1, ST/R002371/1, and ST/S002502/1, Durham University, and STFC operations grant ST/R000832/1. DiRAC is part of the National e-Infrastructure.","doi":"10.1093/mnras/stae2307","file":[{"checksum":"9ea6285dd1d04d7a9e7b40a4c9e11edb","success":1,"date_updated":"2024-11-12T07:17:26Z","file_id":"18542","file_name":"2024_MonthlyNRoyalAstronSoc_Pizzati.pdf","file_size":2954312,"date_created":"2024-11-12T07:17:26Z","content_type":"application/pdf","relation":"main_file","creator":"dernst","access_level":"open_access"}],"publisher":"Oxford University Press"},{"type":"journal_article","publication":"Astrophysical Journal","oa_version":"Published Version","scopus_import":"1","date_created":"2024-11-10T23:01:59Z","external_id":{"arxiv":["2406.17177"],"isi":["001339486900001"]},"has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"Recent works have constrained the binary fraction of evolved populations of massive stars in local galaxies such as red supergiants and Wolf–Rayet stars, but the binary fraction of yellow supergiants (YSGs) in the Hertzsprung gap remains unconstrained. Binary evolution theory predicts that the Hertzsprung gap is home to multiple populations of binary systems with varied evolutionary histories. In this paper, we develop a method to distinguish single YSGs from YSG plus O- or B-type main-sequence binaries using optical and ultraviolet photometry, and then apply this method to identify candidate YSG binaries in the Magellanic Clouds. After constructing a set of combined stellar atmosphere models, we find that optical photometry is, given typical measurement and reddening uncertainties, sufficient to discern single YSGs from YSG+OB binaries if the OB-star is at least ∼5M⊙ for Teff,YSG ∼ 4000 K, but requires a ∼20M⊙ OB star for YSGs up to Teff,YSG ∼ 9000 K. For these hotter YSG temperatures, ultraviolet photometry allows binaries with OB companions as small as ∼7M⊙ to be identified. We use color–color spaces developed from these models to search for evidence of excess blue or ultraviolet light in a set of ∼1000 YSG candidates in the Magellanic Clouds. We identify hundreds of candidate YSG binary systems and report a preliminary fraction of YSGs that show a blue/UV color excess of 20%–60%. Spectroscopic follow-up is now required to confirm the true nature of this population."}],"language":[{"iso":"eng"}],"citation":{"chicago":"O’Grady, Anna J.G., Maria R. Drout, Kathryn F. Neugent, Bethany Ludwig, Ylva Louise Linsdotter Götberg, and B. M. Gaensler. “Binary Yellow Supergiants in the Magellanic Clouds. I. Photometric Candidate Identification.” <i>Astrophysical Journal</i>. IOP Publishing, 2024. <a href=\"https://doi.org/10.3847/1538-4357/ad778a\">https://doi.org/10.3847/1538-4357/ad778a</a>.","apa":"O’Grady, A. J. G., Drout, M. R., Neugent, K. F., Ludwig, B., Götberg, Y. L. L., &#38; Gaensler, B. M. (2024). Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification. <i>Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ad778a\">https://doi.org/10.3847/1538-4357/ad778a</a>","ieee":"A. J. G. O’Grady, M. R. Drout, K. F. Neugent, B. Ludwig, Y. L. L. Götberg, and B. M. Gaensler, “Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification,” <i>Astrophysical Journal</i>, vol. 975. IOP Publishing, 2024.","ista":"O’Grady AJG, Drout MR, Neugent KF, Ludwig B, Götberg YLL, Gaensler BM. 2024. Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification. Astrophysical Journal. 975, 29.","ama":"O’Grady AJG, Drout MR, Neugent KF, Ludwig B, Götberg YLL, Gaensler BM. Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification. <i>Astrophysical Journal</i>. 2024;975. doi:<a href=\"https://doi.org/10.3847/1538-4357/ad778a\">10.3847/1538-4357/ad778a</a>","mla":"O’Grady, Anna J. G., et al. “Binary Yellow Supergiants in the Magellanic Clouds. I. Photometric Candidate Identification.” <i>Astrophysical Journal</i>, vol. 975, 29, IOP Publishing, 2024, doi:<a href=\"https://doi.org/10.3847/1538-4357/ad778a\">10.3847/1538-4357/ad778a</a>.","short":"A.J.G. O’Grady, M.R. Drout, K.F. Neugent, B. Ludwig, Y.L.L. Götberg, B.M. Gaensler, Astrophysical Journal 975 (2024)."},"article_type":"original","DOAJ_listed":"1","OA_place":"publisher","intvolume":"       975","ddc":["520"],"arxiv":1,"date_updated":"2025-09-08T14:37:18Z","OA_type":"gold","author":[{"full_name":"O’Grady, Anna J.G.","first_name":"Anna J.G.","last_name":"O’Grady"},{"first_name":"Maria R.","last_name":"Drout","full_name":"Drout, Maria R."},{"last_name":"Neugent","first_name":"Kathryn F.","full_name":"Neugent, Kathryn F."},{"full_name":"Ludwig, Bethany","last_name":"Ludwig","first_name":"Bethany"},{"orcid":"0000-0002-6960-6911","first_name":"Ylva Louise Linsdotter","last_name":"Götberg","full_name":"Götberg, Ylva Louise Linsdotter","id":"d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d"},{"full_name":"Gaensler, B. M.","last_name":"Gaensler","first_name":"B. M."}],"year":"2024","publication_status":"published","file_date_updated":"2024-11-11T09:20:45Z","volume":975,"month":"11","quality_controlled":"1","_id":"18524","date_published":"2024-11-01T00:00:00Z","article_number":"29","isi":1,"file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","date_created":"2024-11-11T09:20:45Z","content_type":"application/pdf","file_size":34634395,"success":1,"checksum":"0e9bb88b5048ecc782ac27953c84b8ce","date_updated":"2024-11-11T09:20:45Z","file_id":"18535","file_name":"2024_AstrophysicalJour_Grady.pdf"}],"doi":"10.3847/1538-4357/ad778a","acknowledgement":"The authors thank Aaron Tohuvavohu, Katie Breivik, Marten van Kerkwijk, Jakub Klencki, Eva Laplace, and Dae-Sik Moon for helpful discussions, and Adiv Paradise for helpful edits. The authors also thank the anonymous reviewer for a helpful and constructive referee report.\r\nThe authors at the University of Toronto acknowledge that the land on which the University of Toronto operates is the traditional territory of the Huron–Wendat, the Seneca, and the Mississaugas of the Credit River. They are grateful to have the opportunity to work on this land.\r\nThe Dunlap Institute is funded through an endowment established by the David Dunlap family and the University of Toronto.\r\nA.J.G.O. is supported by a McWilliams Fellowship at Carnegie Mellon University. M.R.D. acknowledges support from the NSERC through grant RGPIN-2019-06186, the Canada Research Chairs Program, and the Dunlap Institute at the University of Toronto. B.M.G. acknowledges the support of the Natural Sciences and Engineering Research Council of Canada (NSERC) through grant RGPIN-2022-03163, and of the Canada Research Chairs program. Support for this work was provided by NASA through the NASA Hubble Fellowship Program grant Nos. HST-HF2-51457.001-A and HST-HF2-51516 awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., for NASA, under contract NAS5-26555.\r\nThis research has made use of the SIMBAD database (M. Wenger et al. 2000), operated at CDS, Strasbourg, France, and the SVO Filter Profile Service 13 supported by the Spanish MINECO through grant AYA2017-84089 (C. Rodrigo et al. 2012, 2020).\r\nThis research has made use of the following software: astropy (Astropy Collaboration et al. 2013, 2018, 2022), IRAF (D. Tody 1986, 1993), and TOPCAT (M. B. Taylor 2005).","publisher":"IOP Publishing","article_processing_charge":"No","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","title":"Binary yellow supergiants in the Magellanic Clouds. I. Photometric candidate identification","oa":1,"day":"01","department":[{"_id":"YlGo"}]},{"acknowledgement":"We would like to thank Janice Pennington for her support with electron tomography data collection, Dr. Ingrid Jordon-Thaden, director of the Botany Garden and Greenhouse of University of Wisconsin Madison, for her invaluable assistance collecting plant materials, Dr. Marie Trest for providing Chara specimens, and Dr. Nicholas Keuler for his advice on statistical analyses. We thank Charlie Hamilton for exploring the initial computational model. This work was supported by grant NSF MCB 2114603 and NIH 1S10OD026769-01 to M.S.O. F.F acknowledges support as a NOMIS Fellow from the NOMIS Foundation. A.Š. acknowledges ERC Starting Grant “NEPA” 802960.","doi":"10.1073/pnas.2409407121","file":[{"creator":"dernst","relation":"main_file","access_level":"open_access","date_created":"2024-11-11T09:35:15Z","content_type":"application/pdf","file_size":5268074,"checksum":"21c82d2ab58ff99b2bd0489797be42e5","success":1,"file_name":"2024_PNAS_Weiner.pdf","file_id":"18538","date_updated":"2024-11-11T09:35:15Z"}],"isi":1,"publisher":"National Academy of Sciences","_id":"18526","date_published":"2024-10-29T00:00:00Z","quality_controlled":"1","article_number":"e2409407121","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"title":"Endosomal membrane budding patterns in plants","day":"29","department":[{"_id":"AnSa"}],"article_processing_charge":"Yes (in subscription journal)","publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"intvolume":"       121","OA_place":"publisher","date_updated":"2025-09-08T14:38:35Z","ddc":["570"],"project":[{"grant_number":"802960","name":"Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines","call_identifier":"H2020","_id":"eba2549b-77a9-11ec-83b8-a81e493eae4e"}],"OA_type":"hybrid","date_created":"2024-11-10T23:01:59Z","publication":"Proceedings of the National Academy of Sciences of the United States of America","scopus_import":"1","oa_version":"Published Version","type":"journal_article","abstract":[{"lang":"eng","text":"Multivesicular endosomes (MVEs) sequester membrane proteins destined for degradation within intralumenal vesicles (ILVs), a process mediated by the membrane-remodeling action of Endosomal Sorting Complex Required for Transport (ESCRT) proteins. In Arabidopsis, endosomal membrane constriction and scission are uncoupled, resulting in the formation of extensive concatenated ILV networks and enhancing cargo sequestration efficiency. Here, we used a combination of electron tomography, computer simulations, and mathematical modeling to address the questions of when concatenated ILV networks evolved in plants and what drives their formation. Through morphometric analyses of tomographic reconstructions of endosomes across yeast, algae, and various land plants, we have found that ILV concatenation is widespread within plant species, but only prevalent in seed plants, especially in flowering plants. Multiple budding sites that require the formation of pores in the limiting membrane were only identified in hornworts and seed plants, suggesting that this mechanism has evolved independently in both plant lineages. To identify the conditions under which these multiple budding sites can arise, we used particle-based molecular dynamics simulations and found that changes in ESCRT filament properties, such as filament curvature and membrane binding energy, can generate the membrane shapes observed in multiple budding sites. To understand the relationship between membrane budding activity and ILV network topology, we performed computational simulations and identified a set of membrane remodeling parameters that can recapitulate our tomographic datasets."}],"has_accepted_license":"1","status":"public","external_id":{"pmid":["39441629"],"isi":["001349500800007"]},"article_type":"original","citation":{"ista":"Weiner E, Berryman E, Frey FF, Solís AG, Leier A, Lago TM, Šarić A, Otegui MS. 2024. Endosomal membrane budding patterns in plants. Proceedings of the National Academy of Sciences of the United States of America. 121(44), e2409407121.","ama":"Weiner E, Berryman E, Frey FF, et al. Endosomal membrane budding patterns in plants. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2024;121(44). doi:<a href=\"https://doi.org/10.1073/pnas.2409407121\">10.1073/pnas.2409407121</a>","ieee":"E. Weiner <i>et al.</i>, “Endosomal membrane budding patterns in plants,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 44. National Academy of Sciences, 2024.","apa":"Weiner, E., Berryman, E., Frey, F. F., Solís, A. G., Leier, A., Lago, T. M., … Otegui, M. S. (2024). Endosomal membrane budding patterns in plants. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.2409407121\">https://doi.org/10.1073/pnas.2409407121</a>","short":"E. Weiner, E. Berryman, F.F. Frey, A.G. Solís, A. Leier, T.M. Lago, A. Šarić, M.S. Otegui, Proceedings of the National Academy of Sciences of the United States of America 121 (2024).","mla":"Weiner, Ethan, et al. “Endosomal Membrane Budding Patterns in Plants.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 121, no. 44, e2409407121, National Academy of Sciences, 2024, doi:<a href=\"https://doi.org/10.1073/pnas.2409407121\">10.1073/pnas.2409407121</a>.","chicago":"Weiner, Ethan, Elizabeth Berryman, Felix F Frey, Ariadna González Solís, André Leier, Tatiana Marquez Lago, Anđela Šarić, and Marisa S. Otegui. “Endosomal Membrane Budding Patterns in Plants.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2024. <a href=\"https://doi.org/10.1073/pnas.2409407121\">https://doi.org/10.1073/pnas.2409407121</a>."},"ec_funded":1,"language":[{"iso":"eng"}],"year":"2024","publication_status":"published","file_date_updated":"2024-11-11T09:35:15Z","issue":"44","volume":121,"month":"10","author":[{"first_name":"Ethan","last_name":"Weiner","full_name":"Weiner, Ethan"},{"full_name":"Berryman, Elizabeth","last_name":"Berryman","first_name":"Elizabeth"},{"full_name":"Frey, Felix F","id":"a0270b37-8f1a-11ec-95c7-8e710c59a4f3","orcid":"0000-0001-8501-6017","first_name":"Felix F","last_name":"Frey"},{"full_name":"Solís, Ariadna González","first_name":"Ariadna González","last_name":"Solís"},{"full_name":"Leier, André","last_name":"Leier","first_name":"André"},{"full_name":"Lago, Tatiana Marquez","first_name":"Tatiana Marquez","last_name":"Lago"},{"id":"bf63d406-f056-11eb-b41d-f263a6566d8b","full_name":"Šarić, Anđela","first_name":"Anđela","orcid":"0000-0002-7854-2139","last_name":"Šarić"},{"last_name":"Otegui","first_name":"Marisa S.","full_name":"Otegui, Marisa S."}],"pmid":1},{"pmid":1,"page":"4740-4757.e12","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"PreCl"}],"author":[{"full_name":"Ramadhin, Anisha R.","first_name":"Anisha R.","last_name":"Ramadhin"},{"full_name":"Lee, Shun-Hsiao","first_name":"Shun-Hsiao","last_name":"Lee"},{"first_name":"Di","last_name":"Zhou","full_name":"Zhou, Di"},{"last_name":"Testa Salmazo","first_name":"Anita P","full_name":"Testa Salmazo, Anita P","id":"41F1F098-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Camila","last_name":"Gonzalo-Hansen","full_name":"Gonzalo-Hansen, Camila"},{"full_name":"van Sluis, Marjolein","last_name":"van Sluis","first_name":"Marjolein"},{"full_name":"Blom, Cindy M.A.","last_name":"Blom","first_name":"Cindy M.A."},{"first_name":"Roel C.","last_name":"Janssens","full_name":"Janssens, Roel C."},{"full_name":"Raams, Anja","first_name":"Anja","last_name":"Raams"},{"full_name":"Dekkers, Dick","first_name":"Dick","last_name":"Dekkers"},{"full_name":"Bezstarosti, Karel","first_name":"Karel","last_name":"Bezstarosti"},{"full_name":"Slade, Dea","first_name":"Dea","last_name":"Slade"},{"full_name":"Vermeulen, Wim","last_name":"Vermeulen","first_name":"Wim"},{"last_name":"Pines","first_name":"Alex","full_name":"Pines, Alex"},{"first_name":"Jeroen A.A.","last_name":"Demmers","full_name":"Demmers, Jeroen A.A."},{"orcid":"0000-0003-0893-7036","first_name":"Carrie A","last_name":"Bernecky","full_name":"Bernecky, Carrie A","id":"2CB9DFE2-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Sixma","first_name":"Titia K.","full_name":"Sixma, Titia K."},{"first_name":"Jurgen A.","last_name":"Marteijn","full_name":"Marteijn, Jurgen A."}],"issue":"24","volume":84,"month":"12","year":"2024","publication_status":"published","file_date_updated":"2025-01-13T11:17:35Z","article_type":"original","citation":{"ista":"Ramadhin AR, Lee S-H, Zhou D, Testa Salmazo AP, Gonzalo-Hansen C, van Sluis M, Blom CMA, Janssens RC, Raams A, Dekkers D, Bezstarosti K, Slade D, Vermeulen W, Pines A, Demmers JAA, Bernecky C, Sixma TK, Marteijn JA. 2024. STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. Molecular Cell. 84(24), 4740–4757.e12.","ama":"Ramadhin AR, Lee S-H, Zhou D, et al. STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. <i>Molecular Cell</i>. 2024;84(24):4740-4757.e12. doi:<a href=\"https://doi.org/10.1016/j.molcel.2024.10.030\">10.1016/j.molcel.2024.10.030</a>","ieee":"A. R. Ramadhin <i>et al.</i>, “STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment,” <i>Molecular Cell</i>, vol. 84, no. 24. Elsevier, p. 4740–4757.e12, 2024.","apa":"Ramadhin, A. R., Lee, S.-H., Zhou, D., Testa Salmazo, A. P., Gonzalo-Hansen, C., van Sluis, M., … Marteijn, J. A. (2024). STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment. <i>Molecular Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molcel.2024.10.030\">https://doi.org/10.1016/j.molcel.2024.10.030</a>","short":"A.R. Ramadhin, S.-H. Lee, D. Zhou, A.P. Testa Salmazo, C. Gonzalo-Hansen, M. van Sluis, C.M.A. Blom, R.C. Janssens, A. Raams, D. Dekkers, K. Bezstarosti, D. Slade, W. Vermeulen, A. Pines, J.A.A. Demmers, C. Bernecky, T.K. Sixma, J.A. Marteijn, Molecular Cell 84 (2024) 4740–4757.e12.","mla":"Ramadhin, Anisha R., et al. “STK19 Drives Transcription-Coupled Repair by Stimulating Repair Complex Stability, RNA Pol II Ubiquitylation, and TFIIH Recruitment.” <i>Molecular Cell</i>, vol. 84, no. 24, Elsevier, 2024, p. 4740–4757.e12, doi:<a href=\"https://doi.org/10.1016/j.molcel.2024.10.030\">10.1016/j.molcel.2024.10.030</a>.","chicago":"Ramadhin, Anisha R., Shun-Hsiao Lee, Di Zhou, Anita P Testa Salmazo, Camila Gonzalo-Hansen, Marjolein van Sluis, Cindy M.A. Blom, et al. “STK19 Drives Transcription-Coupled Repair by Stimulating Repair Complex Stability, RNA Pol II Ubiquitylation, and TFIIH Recruitment.” <i>Molecular Cell</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.molcel.2024.10.030\">https://doi.org/10.1016/j.molcel.2024.10.030</a>."},"language":[{"iso":"eng"}],"date_created":"2024-11-15T12:12:54Z","oa_version":"Published Version","scopus_import":"1","publication":"Molecular Cell","type":"journal_article","abstract":[{"lang":"eng","text":"Transcription-coupled nucleotide excision repair (TC-NER) efficiently eliminates DNA damage that impedes gene transcription by RNA polymerase II (RNA Pol II). TC-NER is initiated by the recognition of lesion-stalled RNA Pol II by CSB, which recruits the CRL4CSA ubiquitin ligase and UVSSA. RNA Pol II ubiquitylation at RPB1-K1268 by CRL4CSA serves as a critical TC-NER checkpoint, governing RNA Pol II stability and initiating DNA damage excision by TFIIH recruitment. However, the precise regulatory mechanisms of CRL4CSA activity and TFIIH recruitment remain elusive. Here, we reveal human serine/threonine-protein kinase 19 (STK19) as a TC-NER factor, which is essential for correct DNA damage removal and subsequent transcription restart. Cryogenic electron microscopy (cryo-EM) studies demonstrate that STK19 is an integral part of the RNA Pol II-TC-NER complex, bridging CSA, UVSSA, RNA Pol II, and downstream DNA. STK19 stimulates TC-NER complex stability and CRL4CSA activity, resulting in efficient RNA Pol II ubiquitylation and correct UVSSA and TFIIH binding. These findings underscore the crucial role of STK19 as a core TC-NER component."}],"has_accepted_license":"1","external_id":{"pmid":["39547223"],"isi":["001395711300001"]},"status":"public","OA_type":"hybrid","OA_place":"publisher","intvolume":"        84","date_updated":"2025-09-08T14:42:50Z","ddc":["570"],"article_processing_charge":"No","publication_identifier":{"issn":["1097-2765"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"day":"19","department":[{"_id":"CaBe"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"title":"STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment","date_published":"2024-12-19T00:00:00Z","_id":"18553","quality_controlled":"1","file":[{"file_size":25071994,"success":1,"checksum":"e051e2766b2d424983778f742cb7c5ed","date_updated":"2025-01-13T11:17:35Z","file_id":"18844","file_name":"2024_MolecularCell_Ramadhin.pdf","relation":"main_file","creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_created":"2025-01-13T11:17:35Z"}],"doi":"10.1016/j.molcel.2024.10.030","acknowledgement":"We thank N. Thompson and R. Burgess for the 8WG16 hybridoma cell line. This research was further supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Lab Support Facility (LSF) and the Preclinical Facility (PCF). This work is part of the Oncode Institute, which is partly financed by the Dutch Cancer Society. Research at the Netherlands Cancer Institute is supported by institutional grants of the Dutch Cancer Society and the Dutch Ministry of Health, Welfare and Sport. This study was supported by a VICI (VI.C.182.025) and a TOP Grant (714.017.003) of the Netherlands Organization for Scientific Research.","isi":1,"publisher":"Elsevier"},{"arxiv":1,"ddc":["510"],"date_updated":"2026-04-07T12:32:19Z","OA_place":"publisher","intvolume":"       405","OA_type":"hybrid","external_id":{"pmid":["39526190"],"isi":["001348943900004"],"arxiv":["2403.10359"]},"has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"We prove the Eigenstate Thermalization Hypothesis for general Wigner-type matrices in the bulk of the self-consistent spectrum, with optimal control on the fluctuations for obs ervables of arbitrary rank. As the main technical ingredient, we prove rank-uniform optimal local laws for one and two resolvents of a Wigner-type matrix with regular observables. Our results hold under very general conditions on the variance profile, even allowing many vanishing entries, demonstrating that Eigenstate Thermalization occurs robustly across a diverse class of random matrix ensembles, for which the underlying quantum system has a non-trivial spatial structure."}],"corr_author":"1","type":"journal_article","oa_version":"Published Version","date_created":"2024-11-17T23:01:46Z","scopus_import":"1","publication":"Communications in Mathematical Physics","language":[{"iso":"eng"}],"citation":{"chicago":"Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” <i>Communications in Mathematical Physics</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s00220-024-05143-y\">https://doi.org/10.1007/s00220-024-05143-y</a>.","mla":"Erdös, László, and Volodymyr Riabov. “Eigenstate Thermalization Hypothesis for Wigner-Type Matrices.” <i>Communications in Mathematical Physics</i>, vol. 405, no. 12, 282, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1007/s00220-024-05143-y\">10.1007/s00220-024-05143-y</a>.","short":"L. Erdös, V. Riabov, Communications in Mathematical Physics 405 (2024).","apa":"Erdös, L., &#38; Riabov, V. (2024). Eigenstate Thermalization Hypothesis for Wigner-type matrices. <i>Communications in Mathematical Physics</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00220-024-05143-y\">https://doi.org/10.1007/s00220-024-05143-y</a>","ista":"Erdös L, Riabov V. 2024. Eigenstate Thermalization Hypothesis for Wigner-type matrices. Communications in Mathematical Physics. 405(12), 282.","ama":"Erdös L, Riabov V. Eigenstate Thermalization Hypothesis for Wigner-type matrices. <i>Communications in Mathematical Physics</i>. 2024;405(12). doi:<a href=\"https://doi.org/10.1007/s00220-024-05143-y\">10.1007/s00220-024-05143-y</a>","ieee":"L. Erdös and V. Riabov, “Eigenstate Thermalization Hypothesis for Wigner-type matrices,” <i>Communications in Mathematical Physics</i>, vol. 405, no. 12. Springer Nature, 2024."},"article_type":"original","publication_status":"published","file_date_updated":"2024-11-18T08:15:07Z","year":"2024","month":"12","volume":405,"issue":"12","related_material":{"record":[{"relation":"dissertation_contains","id":"20575","status":"public"}]},"author":[{"id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","first_name":"László","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"full_name":"Riabov, Volodymyr","id":"1949f904-edfb-11eb-afb5-e2dfddabb93b","first_name":"Volodymyr","last_name":"Riabov"}],"pmid":1,"publisher":"Springer Nature","file":[{"date_created":"2024-11-18T08:15:07Z","content_type":"application/pdf","access_level":"open_access","creator":"dernst","relation":"main_file","file_name":"2024_CommMathPhysics_Erdoes.pdf","file_id":"18562","date_updated":"2024-11-18T08:15:07Z","success":1,"checksum":"c9ae0ea195bd39b8b3a630d492fb00dc","file_size":1426046}],"isi":1,"doi":"10.1007/s00220-024-05143-y","acknowledgement":"Open access funding provided by Institute of Science and Technology (IST Austria).","article_number":"282","_id":"18554","date_published":"2024-12-01T00:00:00Z","quality_controlled":"1","title":"Eigenstate Thermalization Hypothesis for Wigner-type matrices","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"LaEr"}],"day":"01","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0010-3616"],"eissn":["1432-0916"]},"article_processing_charge":"Yes (via OA deal)"},{"volume":320,"month":"10","year":"2024","publication_status":"published","file_date_updated":"2024-11-18T07:49:25Z","alternative_title":["LIPIcs"],"author":[{"orcid":"0000-0001-6249-0832","first_name":"Sebastiano","last_name":"Cultrera di Montesano","full_name":"Cultrera di Montesano, Sebastiano","id":"34D2A09C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Draganov, Ondrej","id":"2B23F01E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-0464-3823","first_name":"Ondrej","last_name":"Draganov"},{"id":"3FB178DA-F248-11E8-B48F-1D18A9856A87","full_name":"Edelsbrunner, Herbert","first_name":"Herbert","orcid":"0000-0002-9823-6833","last_name":"Edelsbrunner"},{"last_name":"Saghafian","first_name":"Morteza","id":"f86f7148-b140-11ec-9577-95435b8df824","full_name":"Saghafian, Morteza"}],"project":[{"_id":"266A2E9E-B435-11E9-9278-68D0E5697425","name":"Alpha Shape Theory Extended","call_identifier":"H2020","grant_number":"788183"},{"grant_number":"Z00342","call_identifier":"FWF","name":"Mathematics, Computer Science","_id":"268116B8-B435-11E9-9278-68D0E5697425"},{"grant_number":"I02979-N35","_id":"2561EBF4-B435-11E9-9278-68D0E5697425","name":"Persistence and stability of geometric complexes","call_identifier":"FWF"}],"OA_type":"gold","intvolume":"       320","OA_place":"publisher","date_updated":"2025-12-02T13:50:50Z","ddc":["510"],"arxiv":1,"ec_funded":1,"citation":{"chicago":"Cultrera di Montesano, Sebastiano, Ondrej Draganov, Herbert Edelsbrunner, and Morteza Saghafian. “The Euclidean MST-Ratio for Bi-Colored Lattices.” In <i>32nd International Symposium on Graph Drawing and Network Visualization</i>, Vol. 320. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024. <a href=\"https://doi.org/10.4230/LIPIcs.GD.2024.3\">https://doi.org/10.4230/LIPIcs.GD.2024.3</a>.","short":"S. Cultrera di Montesano, O. Draganov, H. Edelsbrunner, M. Saghafian, in:, 32nd International Symposium on Graph Drawing and Network Visualization, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024.","mla":"Cultrera di Montesano, Sebastiano, et al. “The Euclidean MST-Ratio for Bi-Colored Lattices.” <i>32nd International Symposium on Graph Drawing and Network Visualization</i>, vol. 320, 3, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2024, doi:<a href=\"https://doi.org/10.4230/LIPIcs.GD.2024.3\">10.4230/LIPIcs.GD.2024.3</a>.","ama":"Cultrera di Montesano S, Draganov O, Edelsbrunner H, Saghafian M. The Euclidean MST-ratio for bi-colored lattices. In: <i>32nd International Symposium on Graph Drawing and Network Visualization</i>. Vol 320. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2024. doi:<a href=\"https://doi.org/10.4230/LIPIcs.GD.2024.3\">10.4230/LIPIcs.GD.2024.3</a>","ista":"Cultrera di Montesano S, Draganov O, Edelsbrunner H, Saghafian M. 2024. The Euclidean MST-ratio for bi-colored lattices. 32nd International Symposium on Graph Drawing and Network Visualization. GD: Graph Drawing and Network Visualization, LIPIcs, vol. 320, 3.","ieee":"S. Cultrera di Montesano, O. Draganov, H. Edelsbrunner, and M. Saghafian, “The Euclidean MST-ratio for bi-colored lattices,” in <i>32nd International Symposium on Graph Drawing and Network Visualization</i>, Vienna, Austria, 2024, vol. 320.","apa":"Cultrera di Montesano, S., Draganov, O., Edelsbrunner, H., &#38; Saghafian, M. (2024). The Euclidean MST-ratio for bi-colored lattices. In <i>32nd International Symposium on Graph Drawing and Network Visualization</i> (Vol. 320). Vienna, Austria: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPIcs.GD.2024.3\">https://doi.org/10.4230/LIPIcs.GD.2024.3</a>"},"language":[{"iso":"eng"}],"oa_version":"Published Version","publication":"32nd International Symposium on Graph Drawing and Network Visualization","date_created":"2024-11-17T23:01:47Z","scopus_import":"1","type":"conference","corr_author":"1","abstract":[{"lang":"eng","text":"Given a finite set, A ⊆ ℝ², and a subset, B ⊆ A, the MST-ratio is the combined length of the minimum spanning trees of B and A⧵B divided by the length of the minimum spanning tree of A. The question of the supremum, over all sets A, of the maximum, over all subsets B, is related to the Steiner ratio, and we prove this sup-max is between 2.154 and 2.427. Restricting ourselves to 2-dimensional lattices, we prove that the sup-max is 2, while the inf-max is 1.25. By some margin the most difficult of these results is the upper bound for the inf-max, which we prove by showing that the hexagonal lattice cannot have MST-ratio larger than 1.25."}],"has_accepted_license":"1","external_id":{"arxiv":["2403.10204"],"isi":["001540278400001"]},"status":"public","day":"28","department":[{"_id":"HeEd"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"The Euclidean MST-ratio for bi-colored lattices","article_processing_charge":"Yes","publication_identifier":{"issn":["1868-8969"],"isbn":["9783959773430"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme, grant no. 788183, from the Wittgenstein Prize, Austrian Science Fund (FWF), grant no. Z 342-N31, and from the DFG Collaborative Research Center TRR 109, \"Discretization in Geometry and Dynamics\", Austrian Science Fund (FWF), grant no. I 02979-N35.","doi":"10.4230/LIPIcs.GD.2024.3","isi":1,"file":[{"file_name":"2024_LIPIcs_CultreradiMontesano.pdf","file_id":"18560","date_updated":"2024-11-18T07:49:25Z","success":1,"checksum":"5f9b35e115c3d375e99be78da9054cb4","file_size":908541,"content_type":"application/pdf","date_created":"2024-11-18T07:49:25Z","access_level":"open_access","creator":"dernst","relation":"main_file"}],"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","conference":{"start_date":"2024-09-18","location":"Vienna, Austria","end_date":"2024-09-20","name":"GD: Graph Drawing and Network Visualization"},"date_published":"2024-10-28T00:00:00Z","_id":"18556","quality_controlled":"1","article_number":"3"},{"title":"High-girth Steiner triple systems","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"MaKw"}],"day":"01","publication_identifier":{"eissn":["1939-8980"],"issn":["0003-486X"]},"article_processing_charge":"No","publisher":"Princeton University","doi":"10.4007/annals.2024.200.3.4","isi":1,"acknowledgement":"Sah and Sawhney were supported by NSF Graduate Research Fellowship Program DGE1745302. Sah was supported by the PD Soros Fellowship. Simkin was supported by the Center of Mathematical Sciences and Applications at Harvard University.","quality_controlled":"1","_id":"18559","date_published":"2024-11-01T00:00:00Z","publication_status":"published","year":"2024","month":"11","volume":200,"issue":"3","author":[{"first_name":"Matthew Alan","orcid":"0000-0002-4003-7567","last_name":"Kwan","id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","full_name":"Kwan, Matthew Alan"},{"last_name":"Sah","first_name":"Ashwin","full_name":"Sah, Ashwin"},{"full_name":"Sawhney, Mehtaab","first_name":"Mehtaab","last_name":"Sawhney"},{"last_name":"Simkin","first_name":"Michael","full_name":"Simkin, Michael"}],"page":"1059-1156","arxiv":1,"date_updated":"2025-09-08T14:40:55Z","intvolume":"       200","OA_place":"repository","OA_type":"green","status":"public","external_id":{"arxiv":["2201.04554"],"isi":["001366233800004"]},"abstract":[{"lang":"eng","text":"We prove a 1973 conjecture due to Erdős on the existence of Steiner triple systems with arbitrarily high girth."}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2201.04554"}],"type":"journal_article","corr_author":"1","scopus_import":"1","oa_version":"Preprint","publication":"Annals of Mathematics","date_created":"2024-11-17T23:01:48Z","language":[{"iso":"eng"}],"article_type":"original","citation":{"chicago":"Kwan, Matthew Alan, Ashwin Sah, Mehtaab Sawhney, and Michael Simkin. “High-Girth Steiner Triple Systems.” <i>Annals of Mathematics</i>. Princeton University, 2024. <a href=\"https://doi.org/10.4007/annals.2024.200.3.4\">https://doi.org/10.4007/annals.2024.200.3.4</a>.","ieee":"M. A. Kwan, A. Sah, M. Sawhney, and M. Simkin, “High-girth Steiner triple systems,” <i>Annals of Mathematics</i>, vol. 200, no. 3. Princeton University, pp. 1059–1156, 2024.","ama":"Kwan MA, Sah A, Sawhney M, Simkin M. High-girth Steiner triple systems. <i>Annals of Mathematics</i>. 2024;200(3):1059-1156. doi:<a href=\"https://doi.org/10.4007/annals.2024.200.3.4\">10.4007/annals.2024.200.3.4</a>","ista":"Kwan MA, Sah A, Sawhney M, Simkin M. 2024. High-girth Steiner triple systems. Annals of Mathematics. 200(3), 1059–1156.","apa":"Kwan, M. A., Sah, A., Sawhney, M., &#38; Simkin, M. (2024). High-girth Steiner triple systems. <i>Annals of Mathematics</i>. Princeton University. <a href=\"https://doi.org/10.4007/annals.2024.200.3.4\">https://doi.org/10.4007/annals.2024.200.3.4</a>","short":"M.A. Kwan, A. Sah, M. Sawhney, M. Simkin, Annals of Mathematics 200 (2024) 1059–1156.","mla":"Kwan, Matthew Alan, et al. “High-Girth Steiner Triple Systems.” <i>Annals of Mathematics</i>, vol. 200, no. 3, Princeton University, 2024, pp. 1059–156, doi:<a href=\"https://doi.org/10.4007/annals.2024.200.3.4\">10.4007/annals.2024.200.3.4</a>."}},{"series_title":"LNCS","month":"10","volume":15230,"publication_status":"published","year":"2024","page":"154-164","author":[{"first_name":"Thomas A","orcid":"0000-0002-2985-7724","last_name":"Henzinger","id":"40876CD8-F248-11E8-B48F-1D18A9856A87","full_name":"Henzinger, Thomas A"}],"alternative_title":["LNCS"],"OA_type":"closed access","date_updated":"2025-08-05T12:19:50Z","intvolume":"     15230","language":[{"iso":"eng"}],"citation":{"short":"T.A. Henzinger, in:, S. Graf, P. Pettersson, B. Steffen (Eds.), Real Time and Such, Springer Nature, Cham, 2024, pp. 154–164.","mla":"Henzinger, Thomas A. “Reminiscences of a Real-Time Researcher.” <i>Real Time and Such</i>, edited by Susanne Graf et al., vol. 15230, Springer Nature, 2024, pp. 154–64, doi:<a href=\"https://doi.org/10.1007/978-3-031-73751-0_12\">10.1007/978-3-031-73751-0_12</a>.","ama":"Henzinger TA. Reminiscences of a Real-Time Researcher. In: Graf S, Pettersson P, Steffen B, eds. <i>Real Time and Such</i>. Vol 15230. LNCS. Cham: Springer Nature; 2024:154-164. doi:<a href=\"https://doi.org/10.1007/978-3-031-73751-0_12\">10.1007/978-3-031-73751-0_12</a>","ista":"Henzinger TA. 2024.Reminiscences of a Real-Time Researcher. In: Real Time and Such. LNCS, vol. 15230, 154–164.","ieee":"T. A. Henzinger, “Reminiscences of a Real-Time Researcher,” in <i>Real Time and Such</i>, vol. 15230, S. Graf, P. Pettersson, and B. Steffen, Eds. Cham: Springer Nature, 2024, pp. 154–164.","apa":"Henzinger, T. A. (2024). Reminiscences of a Real-Time Researcher. In S. Graf, P. Pettersson, &#38; B. Steffen (Eds.), <i>Real Time and Such</i> (Vol. 15230, pp. 154–164). Cham: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-73751-0_12\">https://doi.org/10.1007/978-3-031-73751-0_12</a>","chicago":"Henzinger, Thomas A. “Reminiscences of a Real-Time Researcher.” In <i>Real Time and Such</i>, edited by Susanne Graf, Paul Pettersson, and Bernhard Steffen, 15230:154–64. LNCS. Cham: Springer Nature, 2024. <a href=\"https://doi.org/10.1007/978-3-031-73751-0_12\">https://doi.org/10.1007/978-3-031-73751-0_12</a>."},"status":"public","abstract":[{"lang":"eng","text":"I give a personal account about the wave of new research activities that rose in the 1990s on the specification, verification, and control of real-time systems."}],"type":"book_chapter","corr_author":"1","date_created":"2024-11-18T09:10:06Z","scopus_import":"1","publication":"Real Time and Such","oa_version":"None","department":[{"_id":"ToHe"}],"editor":[{"last_name":"Graf","first_name":"Susanne","full_name":"Graf, Susanne"},{"first_name":"Paul","last_name":"Pettersson","full_name":"Pettersson, Paul"},{"last_name":"Steffen","first_name":"Bernhard","full_name":"Steffen, Bernhard"}],"day":"23","title":"Reminiscences of a Real-Time Researcher","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0302-9743"],"eisbn":["9783031737510"],"eissn":["1611-3349"],"isbn":["9783031737503"]},"article_processing_charge":"No","publisher":"Springer Nature","doi":"10.1007/978-3-031-73751-0_12","acknowledgement":"I thank all my collaborators over the years. None of the mentioned contributions would have been possible without them. I also apologize for all omissions. The selection of contributions in this essay reflects primarily my personal involvement rather than any measure of importance.","place":"Cham","quality_controlled":"1","_id":"18563","date_published":"2024-10-23T00:00:00Z"},{"alternative_title":["ISTA Thesis"],"author":[{"id":"46046B7A-F248-11E8-B48F-1D18A9856A87","full_name":"Satapathy, Roshan K","first_name":"Roshan K","orcid":"0009-0006-2974-5075","last_name":"Satapathy"}],"acknowledged_ssus":[{"_id":"M-Shop"}],"page":"114","year":"2024","publication_status":"published","file_date_updated":"2024-12-13T10:27:25Z","related_material":{"record":[{"status":"public","id":"18444","relation":"part_of_dissertation"}]},"month":"11","corr_author":"1","type":"dissertation","date_created":"2024-11-19T12:34:30Z","oa_version":"Published Version","has_accepted_license":"1","status":"public","abstract":[{"text":"Locomotion is ubiquitous in the animal kingdom because an animal's survival depends on its ability to navigate its environment to find food, avoid predators and locate potential mates. These behaviours require control mechanisms that can extract information from the environment, particularly visual cues. Selective evolutionary pressures have thus refined such visuomotor transformations in a species-specific manner to meet the specific ecological and ethological challenges of each organism. However, a common challenge across organisms as visual information processing\r\nbecomes increasingly detailed is the mechanisms required to synthesise disparate pieces of information into a coherent percept or unified picture of the world. In this thesis, I investigate how disparate visual information is combined in the brain of Drosophila melanogaster to effectively guide locomotion.\r\nFor this, I first designed and built a behavioural setup to record locomotion and present visual stimuli to freely-walking fruit flies in a closed-loop manner. This setup allowed the investigation of innate visually-guided behaviours, including the optomotor reflex and courtship.\r\nSecond, taking advantage of my system I investigated the optomotor response, a reflexive visual stabilisation behaviour in which flies turn in the direction of global motion to minimise retinal slip. This behaviour is thought to be mediated by Lobula plate tangential cells (LPTCs); a complex network of optic-flow-sensitive neurons essential for self-motion estimation. Using a novel genetic mutant, I demonstrate that electrical coupling between two LPTC subtypes, contralateral HS and H2 neurons, regulates the balance between smooth optomotor turning and saccadic anti-optomotor responses. These findings underscore the critical role of binocular motion cue integration in guiding course control. Finally, I developed a novel behavioural paradigm in which a sexually aroused male fruit fly is presented with an optomotor distractor. This setup creates competition between two visual behaviours, courtship tracking and the  optomotor response, enabling me to explore how the visual system resolves this conflict. In this setting, males\r\nengaged in courtship selectively suppress their optomotor response based on the female's location. Furthermore, when this experiment is replicated with an “artificial female”, optogenetically aroused males alternate between tracking and optomotor responses. The probability and dynamics of this switching are determined by the relative strengths of the two competing stimuli. In summary, the results presented in this thesis explore two mechanisms – integration and competition - through which visual information is combined in the brain of the fruit fly to drive locomotion.","lang":"eng"}],"language":[{"iso":"eng"}],"citation":{"chicago":"Satapathy, Roshan K. “Mechanisms of Visual Integration and Competition in Innate Behaviours in Drosophila Melanogaster.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:18568\">https://doi.org/10.15479/at:ista:18568</a>.","short":"R.K. Satapathy, Mechanisms of Visual Integration and Competition in Innate Behaviours in Drosophila Melanogaster, Institute of Science and Technology Austria, 2024.","mla":"Satapathy, Roshan K. <i>Mechanisms of Visual Integration and Competition in Innate Behaviours in Drosophila Melanogaster</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:18568\">10.15479/at:ista:18568</a>.","ama":"Satapathy RK. Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:18568\">10.15479/at:ista:18568</a>","ieee":"R. K. Satapathy, “Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster,” Institute of Science and Technology Austria, 2024.","ista":"Satapathy RK. 2024. Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster. Institute of Science and Technology Austria.","apa":"Satapathy, R. K. (2024). <i>Mechanisms of visual integration and competition in innate behaviours in Drosophila melanogaster</i>. 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I am also grateful for the funding provided by European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie programme (665385) and The German Research Foundation grant DFG (SPP2205) “Evolutionary optimization of neuronal processing”.","file":[{"file_name":"Roshan PhD thesis-Final.pdf","file_id":"18570","date_updated":"2024-11-19T12:39:55Z","checksum":"340f2bfe882c8a85e11ec0687ca15f5e","success":1,"file_size":10960975,"date_created":"2024-11-19T12:39:55Z","content_type":"application/pdf","access_level":"open_access","creator":"rsatapat","relation":"main_file"},{"date_updated":"2024-12-13T10:27:25Z","file_name":"Roshan PhD thesis-Final.docx","file_id":"18571","checksum":"0f846fce60d6ea511e07f77eff59a6a1","file_size":36695917,"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","date_created":"2024-11-19T12:46:47Z","access_level":"closed","relation":"source_file","creator":"rsatapat"}],"doi":"10.15479/at:ista:18568","publisher":"Institute of Science and Technology Austria","degree_awarded":"PhD"},{"has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"Electrophysiological, calcium two-photon recordings and behavioral data for Vega-Zuniga et al.  Relevant information can be found in the 'README.txt' files. "}],"type":"research_data","corr_author":"1","date_created":"2024-11-22T13:48:12Z","oa_version":"Published Version","ec_funded":1,"citation":{"chicago":"Vega Zuniga, Tomas A, Anton L Sumser, Olga Symonova, Peter Koppensteiner, Florian Schmidt, and Maximilian A Jösch. “A Thalamic Hub-and-Spoke Network Enables Visual Perception during Action by Coordinating Visuomotor Dynamics.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/AT:ISTA:18579\">https://doi.org/10.15479/AT:ISTA:18579</a>.","ista":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. 2024. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics, Institute of Science and Technology Austria, <a href=\"https://doi.org/10.15479/AT:ISTA:18579\">10.15479/AT:ISTA:18579</a>.","ieee":"T. A. Vega Zuniga, A. L. Sumser, O. Symonova, P. Koppensteiner, F. Schmidt, and M. A. Jösch, “A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics.” Institute of Science and Technology Austria, 2024.","ama":"Vega Zuniga TA, Sumser AL, Symonova O, Koppensteiner P, Schmidt F, Jösch MA. A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. 2024. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18579\">10.15479/AT:ISTA:18579</a>","apa":"Vega Zuniga, T. A., Sumser, A. L., Symonova, O., Koppensteiner, P., Schmidt, F., &#38; Jösch, M. A. (2024). A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:18579\">https://doi.org/10.15479/AT:ISTA:18579</a>","short":"T.A. Vega Zuniga, A.L. Sumser, O. Symonova, P. Koppensteiner, F. 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Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:18579\">10.15479/AT:ISTA:18579</a>."},"ddc":["570"],"date_updated":"2026-06-18T18:12:08Z","OA_place":"publisher","project":[{"grant_number":"ALTF 1098-2017","name":"Connecting sensory with motor processing in the superior colliculus","_id":"264FEA02-B435-11E9-9278-68D0E5697425"},{"_id":"266D407A-B435-11E9-9278-68D0E5697425","name":"Neuronal networks of salience and spatial detection in the murine superior colliculus","grant_number":"LT000256"},{"_id":"2634E9D2-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Circuits of Visual Attention","grant_number":"756502"},{"grant_number":"101086580","name":"Action Selection in the Midbrain: Neuromodulation of Visuomotor Senses","_id":"bdaf81a8-d553-11ed-ba76-c95961984540"}],"author":[{"last_name":"Vega Zuniga","first_name":"Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","full_name":"Vega Zuniga, Tomas A"},{"id":"3320A096-F248-11E8-B48F-1D18A9856A87","full_name":"Sumser, Anton L","last_name":"Sumser","first_name":"Anton L","orcid":"0000-0002-4792-1881"},{"id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87","full_name":"Symonova, Olga","last_name":"Symonova","first_name":"Olga","orcid":"0000-0003-2012-9947"},{"full_name":"Koppensteiner, Peter","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","last_name":"Koppensteiner","orcid":"0000-0002-3509-1948","first_name":"Peter"},{"last_name":"Schmidt","first_name":"Florian","full_name":"Schmidt, Florian","id":"A2EF226A-AF19-11E9-924C-0525E6697425"},{"id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","full_name":"Jösch, Maximilian A","last_name":"Jösch","first_name":"Maximilian A","orcid":"0000-0002-3937-1330"}],"acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"PreCl"},{"_id":"M-Shop"},{"_id":"Bio"},{"_id":"LifeSc"}],"file_date_updated":"2024-12-09T12:54:55Z","year":"2024","month":"12","related_material":{"record":[{"id":"19076","status":"public","relation":"used_in_publication"}]},"date_published":"2024-12-09T00:00:00Z","_id":"18579","publisher":"Institute of Science and Technology Austria","file":[{"checksum":"8b13990ca1a458ae3f3ae54c2e888564","file_name":"electro_physiology_data.zip","file_id":"18625","date_updated":"2024-12-09T10:24:25Z","file_size":800647957,"content_type":"application/x-zip-compressed","date_created":"2024-12-06T13:28:18Z","creator":"symonova","relation":"main_file","access_level":"open_access"},{"success":1,"checksum":"c5a4d71c5f29c009c3d96a3244532afa","date_updated":"2024-12-09T10:21:10Z","file_name":"NN_vLGN_Ca_data.zip","file_id":"18636","file_size":828410832,"content_type":"application/x-zip-compressed","date_created":"2024-12-09T10:21:10Z","relation":"main_file","creator":"symonova","access_level":"open_access"},{"access_level":"open_access","relation":"main_file","creator":"symonova","content_type":"text/plain","date_created":"2024-12-09T12:54:55Z","file_size":505,"date_updated":"2024-12-09T12:54:55Z","file_name":"readme.txt","file_id":"18637","checksum":"63651df0186196969553dc48b467f6ab","success":1}],"doi":"10.15479/AT:ISTA:18579","acknowledgement":"Freyja Lange, Michael Schunn, and Todor Asenov","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"No","title":"A thalamic hub-and-spoke network enables visual perception during action by coordinating visuomotor dynamics","oa":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","department":[{"_id":"MaJö"}],"day":"09"},{"department":[{"_id":"LifeSc"}],"day":"01","title":"Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"publication_identifier":{"eissn":["1757-6512"]},"article_processing_charge":"Yes","publisher":"Springer Nature","file":[{"file_size":6690494,"checksum":"91edba8edde30d781dce89fdd5cadc39","success":1,"file_id":"18641","file_name":"2024_StemCellResearch_Presen.pdf","date_updated":"2024-12-10T08:28:17Z","creator":"dernst","relation":"main_file","access_level":"open_access","content_type":"application/pdf","date_created":"2024-12-10T08:28:17Z"}],"doi":"10.1186/s13287-024-03960-5","acknowledgement":"We thank the personnel of the Lorenz-Böhler-Unfallkrankenhaus for providing the human tissue waste for primary cell isolation and the New York Stem Cell Foundation Research Institute for providing the human induced pluripotent stem cell line 1013 A and its mesenchymal progenitors. We also thank all our colleagues at the Ludwig Boltzmann Institute for Traumatology for their suggestions and ongoing support of the project. InstaText writing tool (https://instatext.io) was used to edit the English language of the final manuscript.\r\nThis work has received funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie actions (grant agreement No. 657716) and the Transforming European Industry call H2020-NMBP-TRIND-2020 (grant agreement No. 953134), as well as by the FFG Industrienahe Dissertation program (grant agreement No. 867803 and 853056), the FEMtech Praktika program (grant agreement No. 852154, 868917 and 877951) and the Production of the Future program (grant agreement No. 877452).","isi":1,"article_number":"434","_id":"18581","date_published":"2024-12-01T00:00:00Z","quality_controlled":"1","month":"12","volume":15,"file_date_updated":"2024-12-10T08:28:17Z","publication_status":"published","year":"2024","pmid":1,"author":[{"last_name":"Marolt Presen","first_name":"Darja","full_name":"Marolt Presen, Darja"},{"full_name":"Goeschl, Vanessa","last_name":"Goeschl","first_name":"Vanessa"},{"last_name":"Hanetseder","first_name":"Dominik","full_name":"Hanetseder, Dominik"},{"last_name":"Ogrin","first_name":"Laura","full_name":"Ogrin, Laura"},{"last_name":"Stetco","first_name":"Alexandra Larissa","full_name":"Stetco, Alexandra Larissa"},{"full_name":"Tansek, Anja","first_name":"Anja","last_name":"Tansek"},{"full_name":"Pozenel, Laura","last_name":"Pozenel","first_name":"Laura"},{"id":"70abbbb3-88ea-11ec-8e0a-e8c939944834","full_name":"Bruszel, Bella","last_name":"Bruszel","first_name":"Bella"},{"full_name":"Mitulovic, Goran","first_name":"Goran","last_name":"Mitulovic"},{"last_name":"Oesterreicher","first_name":"Johannes","full_name":"Oesterreicher, Johannes"},{"full_name":"Zipperle, Johannes","last_name":"Zipperle","first_name":"Johannes"},{"full_name":"Schaedl, Barbara","last_name":"Schaedl","first_name":"Barbara"},{"full_name":"Holnthoner, Wolfgang","last_name":"Holnthoner","first_name":"Wolfgang"},{"full_name":"Grillari, Johannes","last_name":"Grillari","first_name":"Johannes"},{"last_name":"Redl","first_name":"Heinz","full_name":"Redl, Heinz"}],"OA_type":"gold","ddc":["570"],"date_updated":"2025-09-09T11:41:12Z","intvolume":"        15","OA_place":"publisher","language":[{"iso":"eng"}],"citation":{"short":"D. Marolt Presen, V. Goeschl, D. Hanetseder, L. Ogrin, A.L. Stetco, A. Tansek, L. Pozenel, B. Bruszel, G. Mitulovic, J. Oesterreicher, J. Zipperle, B. Schaedl, W. Holnthoner, J. Grillari, H. Redl, Stem Cell Research and Therapy 15 (2024).","mla":"Marolt Presen, Darja, et al. “Prolonged Cultivation Enhances the Stimulatory Activity of HiPSC Mesenchymal Progenitor-Derived Conditioned Medium.” <i>Stem Cell Research and Therapy</i>, vol. 15, 434, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1186/s13287-024-03960-5\">10.1186/s13287-024-03960-5</a>.","ieee":"D. Marolt Presen <i>et al.</i>, “Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium,” <i>Stem Cell Research and Therapy</i>, vol. 15. Springer Nature, 2024.","ama":"Marolt Presen D, Goeschl V, Hanetseder D, et al. Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. <i>Stem Cell Research and Therapy</i>. 2024;15. doi:<a href=\"https://doi.org/10.1186/s13287-024-03960-5\">10.1186/s13287-024-03960-5</a>","ista":"Marolt Presen D, Goeschl V, Hanetseder D, Ogrin L, Stetco AL, Tansek A, Pozenel L, Bruszel B, Mitulovic G, Oesterreicher J, Zipperle J, Schaedl B, Holnthoner W, Grillari J, Redl H. 2024. Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. Stem Cell Research and Therapy. 15, 434.","apa":"Marolt Presen, D., Goeschl, V., Hanetseder, D., Ogrin, L., Stetco, A. L., Tansek, A., … Redl, H. (2024). Prolonged cultivation enhances the stimulatory activity of hiPSC mesenchymal progenitor-derived conditioned medium. <i>Stem Cell Research and Therapy</i>. Springer Nature. <a href=\"https://doi.org/10.1186/s13287-024-03960-5\">https://doi.org/10.1186/s13287-024-03960-5</a>","chicago":"Marolt Presen, Darja, Vanessa Goeschl, Dominik Hanetseder, Laura Ogrin, Alexandra Larissa Stetco, Anja Tansek, Laura Pozenel, et al. “Prolonged Cultivation Enhances the Stimulatory Activity of HiPSC Mesenchymal Progenitor-Derived Conditioned Medium.” <i>Stem Cell Research and Therapy</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1186/s13287-024-03960-5\">https://doi.org/10.1186/s13287-024-03960-5</a>."},"article_type":"original","DOAJ_listed":"1","status":"public","has_accepted_license":"1","external_id":{"pmid":["39551765"],"isi":["001356479400001"]},"abstract":[{"lang":"eng","text":"Background: Human induced pluripotent stem cells represent a scalable source of youthful tissue progenitors and secretomes for regenerative therapies. The aim of our study was to investigate the potential of conditioned medium (CM) from hiPSC-mesenchymal progenitors (hiPSC-MPs) to stimulate osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells (MSCs). We also investigated whether prolonged cultivation or osteogenic pre-differentiation of hiPSC-MPs could enhance the stimulatory activity of CM.\r\nMethods: MSCs were isolated from 13 donors (age 20–90 years). CM derived from hiPSC-MPs was added to the MSC cultures and the effects on proliferation and osteogenic differentiation were examined after 14 days and 6 weeks. The stimulatory activity of hiPSC-MP-CM was compared with the activity of MSC-derived CM and with the activity of CM prepared from hiPSC-MPs pre-cultured in growth or osteogenic medium for 14 days. Comparative proteomic analysis of CM was performed to gain insight into the molecular components responsible for the stimulatory activity.\r\nResults: Primary bone marrow-derived MSC exhibited variability, with a tendency towards lower proliferation and tri-lineage differentiation in older donors. hiPSC-MP-CM increased the proliferation and alkaline phosphatase activity of MSC from several adult/aged donors after 14 days of continuous supplementation under osteogenic conditions. However, CM supplementation failed to improve the mineralization of MSC pellets after 6 weeks under osteogenic conditions. hiPSC-MP-CM showed greater enhancement of proliferation and ALP activity than CM derived from bone marrow-derived MSCs. Moreover, 14-day cultivation but not osteogenic pre-differentiation of hiPSC-MPs strongly enhanced CM stimulatory activity. Quantitative proteomic analysis of d14-CM revealed a distinct profile of components that formed a highly interconnected associations network with two clusters, one functionally associated with binding and organization of actin/cytoskeletal components and the other with structural constituents of the extracellular matrix, collagen, and growth factor binding. Several hub proteins were identified that were reported to have functions in cell-extracellular matrix interaction, osteogenic differentiation and development.\r\nConclusions: Our data show that hiPSC-MP-CM enhances early osteogenic differentiation of human bone marrow-derived MSCs and that prolonged cultivation of hiPSC-MPs enhances CM-stimulatory activity. Proteomic analysis of the upregulated protein components provides the basis for further optimization of hiPSC-MP-CM for bone regenerative therapies."}],"type":"journal_article","date_created":"2024-11-24T23:01:47Z","publication":"Stem Cell Research and Therapy","scopus_import":"1","oa_version":"Published Version"},{"scopus_import":"1","date_created":"2024-11-24T23:01:48Z","publication":"Nature Communications","oa_version":"Published Version","corr_author":"1","type":"journal_article","abstract":[{"text":"Identification of PIN exporters for auxin, the major coordinative signal in plants, some 25 years ago, signifies a landmark in our understanding of plant-specific mechanisms underlying development and adaptation. Auxin is directionally transported throughout the plant body; a unique feature already envisioned by Darwin and solidified by PINs’ discovery and characterization. The PIN-based auxin distribution network with its complex regulations of PIN expression, localization and activity turned out to underlie a remarkable multitude of developmental processes and represents means to integrate endogenous and environmental signals. Given the recent anniversary, we here summarize past and current developments in this exciting field.","lang":"eng"}],"status":"public","external_id":{"isi":["001356232600004"],"pmid":["39548100"]},"has_accepted_license":"1","article_type":"original","citation":{"chicago":"Luschnig, Christian, and Jiří Friml. “Over 25 Years of Decrypting PIN-Mediated Plant Development.” <i>Nature Communications</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41467-024-54240-y\">https://doi.org/10.1038/s41467-024-54240-y</a>.","short":"C. Luschnig, J. Friml, Nature Communications 15 (2024).","mla":"Luschnig, Christian, and Jiří Friml. “Over 25 Years of Decrypting PIN-Mediated Plant Development.” <i>Nature Communications</i>, vol. 15, 9904, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1038/s41467-024-54240-y\">10.1038/s41467-024-54240-y</a>.","ista":"Luschnig C, Friml J. 2024. Over 25 years of decrypting PIN-mediated plant development. Nature Communications. 15, 9904.","ieee":"C. Luschnig and J. Friml, “Over 25 years of decrypting PIN-mediated plant development,” <i>Nature Communications</i>, vol. 15. Springer Nature, 2024.","ama":"Luschnig C, Friml J. Over 25 years of decrypting PIN-mediated plant development. <i>Nature Communications</i>. 2024;15. doi:<a href=\"https://doi.org/10.1038/s41467-024-54240-y\">10.1038/s41467-024-54240-y</a>","apa":"Luschnig, C., &#38; Friml, J. (2024). Over 25 years of decrypting PIN-mediated plant development. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-024-54240-y\">https://doi.org/10.1038/s41467-024-54240-y</a>"},"DOAJ_listed":"1","language":[{"iso":"eng"}],"intvolume":"        15","OA_place":"publisher","date_updated":"2025-09-08T14:53:48Z","ddc":["580"],"OA_type":"gold","project":[{"_id":"bd76d395-d553-11ed-ba76-f678c14f9033","name":"Peptide receptors for auxin canalization in Arabidopsis","grant_number":"I06123"},{"grant_number":"P37051","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6"}],"author":[{"full_name":"Luschnig, Christian","last_name":"Luschnig","first_name":"Christian"},{"full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří"}],"pmid":1,"year":"2024","publication_status":"published","file_date_updated":"2024-12-03T14:10:54Z","volume":15,"month":"12","_id":"18582","date_published":"2024-12-01T00:00:00Z","quality_controlled":"1","article_number":"9904","doi":"10.1038/s41467-024-54240-y","isi":1,"acknowledgement":"We gratefully acknowledge Leo Gälweiler for authorizing his PIN1 story. We would like to thank Yuanrong Pei for invaluable help with preparing figures. Work in the lab of C.L. is supported by grants from the Austrian Science Fund (PAT 8419423) and by the Gesellschaft für Forschungsförderung Niederösterreich m.b.H. (FTI19-008). The lab of J.F. is supported by the Austrian Science Fund (I 6123-B and P 37051-B).","file":[{"file_size":1426555,"file_name":"2024_NatureComm_Luschnig.pdf","file_id":"18615","date_updated":"2024-12-03T14:10:54Z","success":1,"checksum":"3a31af06f52100d287f1e9d9c2aa1d40","access_level":"open_access","creator":"dernst","relation":"main_file","date_created":"2024-12-03T14:10:54Z","content_type":"application/pdf"}],"publisher":"Springer Nature","article_processing_charge":"Yes","publication_identifier":{"eissn":["2041-1723"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"title":"Over 25 years of decrypting PIN-mediated plant development","day":"01","department":[{"_id":"JiFr"}]},{"author":[{"full_name":"Anastos, Michael","id":"0b2a4358-bb35-11ec-b7b9-e3279b593dbb","first_name":"Michael","last_name":"Anastos"},{"first_name":"Oliver","last_name":"Cooley","id":"43f4ddd0-a46b-11ec-8df6-ef3703bd721d","full_name":"Cooley, Oliver"},{"full_name":"Kang, Mihyun","first_name":"Mihyun","last_name":"Kang"},{"id":"5fca0887-a1db-11eb-95d1-ca9d5e0453b3","full_name":"Kwan, Matthew Alan","last_name":"Kwan","first_name":"Matthew Alan","orcid":"0000-0002-4003-7567"}],"year":"2024","publication_status":"published","file_date_updated":"2024-12-10T08:10:39Z","issue":"6","volume":110,"month":"12","scopus_import":"1","oa_version":"Published Version","date_created":"2024-11-24T23:01:48Z","publication":"Journal of the London Mathematical Society","type":"journal_article","corr_author":"1","abstract":[{"text":"There are a number of well-known problems and conjectures about partitioning graphs to satisfy local constraints. For example, the majority colouring conjecture of Kreutzer, Oum, Seymour, van der Zypen and Wood states that every directed graph has a 3-colouring such that for every vertex v, at most half of the out-neighbours of v have the same colour as \r\n. As another example, the internal partition conjecture, due to DeVos and to Ban and Linial, states that for every d, all but finitely many d-regular graphs have a partition into two non-empty parts such that for every vertex v, at least half of the neighbours of v lie in the same part as v. We prove several results in this spirit: in particular, two of our results are that the majority colouring conjecture holds for Erdős–Rényi random directed graphs (of any density), and that the internal partition conjecture holds if we permit a tiny number of ‘exceptional vertices’. Our proofs involve a variety of techniques, including several different methods to analyse random recolouring processes. One highlight is a personality-changing scheme: we ‘forget’ certain information based on the state of a Markov chain, giving us more independence to work with.","lang":"eng"}],"has_accepted_license":"1","external_id":{"arxiv":["2307.06453"],"isi":["001374738100001"]},"status":"public","citation":{"mla":"Anastos, Michael, et al. “Partitioning Problems via Random Processes.” <i>Journal of the London Mathematical Society</i>, vol. 110, no. 6, e70010, Wiley, 2024, doi:<a href=\"https://doi.org/10.1112/jlms.70010\">10.1112/jlms.70010</a>.","short":"M. Anastos, O. Cooley, M. Kang, M.A. Kwan, Journal of the London Mathematical Society 110 (2024).","apa":"Anastos, M., Cooley, O., Kang, M., &#38; Kwan, M. A. (2024). Partitioning problems via random processes. <i>Journal of the London Mathematical Society</i>. Wiley. <a href=\"https://doi.org/10.1112/jlms.70010\">https://doi.org/10.1112/jlms.70010</a>","ista":"Anastos M, Cooley O, Kang M, Kwan MA. 2024. Partitioning problems via random processes. Journal of the London Mathematical Society. 110(6), e70010.","ama":"Anastos M, Cooley O, Kang M, Kwan MA. Partitioning problems via random processes. <i>Journal of the London Mathematical Society</i>. 2024;110(6). doi:<a href=\"https://doi.org/10.1112/jlms.70010\">10.1112/jlms.70010</a>","ieee":"M. Anastos, O. Cooley, M. Kang, and M. A. Kwan, “Partitioning problems via random processes,” <i>Journal of the London Mathematical Society</i>, vol. 110, no. 6. Wiley, 2024.","chicago":"Anastos, Michael, Oliver Cooley, Mihyun Kang, and Matthew Alan Kwan. “Partitioning Problems via Random Processes.” <i>Journal of the London Mathematical Society</i>. Wiley, 2024. <a href=\"https://doi.org/10.1112/jlms.70010\">https://doi.org/10.1112/jlms.70010</a>."},"ec_funded":1,"article_type":"original","language":[{"iso":"eng"}],"intvolume":"       110","OA_place":"publisher","date_updated":"2025-12-02T13:52:26Z","arxiv":1,"ddc":["510"],"project":[{"grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c"},{"grant_number":"101076777","_id":"bd95085b-d553-11ed-ba76-e55d3349be45","name":"Randomness and structure in combinatorics"}],"OA_type":"hybrid","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"issn":["0024-6107"],"eissn":["1469-7750"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"title":"Partitioning problems via random processes","day":"01","department":[{"_id":"MaKw"}],"date_published":"2024-12-01T00:00:00Z","_id":"18583","quality_controlled":"1","article_number":"e70010","file":[{"relation":"main_file","creator":"dernst","access_level":"open_access","content_type":"application/pdf","date_created":"2024-12-10T08:10:39Z","file_size":539891,"checksum":"98e301e0565d75e3fb50e10e982a5018","success":1,"date_updated":"2024-12-10T08:10:39Z","file_id":"18639","file_name":"2024_JournLondonMathSoc_Anastos.pdf"}],"doi":"10.1112/jlms.70010","acknowledgement":"We are grateful to the anonymous referees for their thorough reading of the paper, and for many suggestions which have improved the exposition throughout.\r\n\r\nMichael Anastos was supported by the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 101034413. Matthew Kwan was supported by ERC Starting Grant ‘RANDSTRUCT’ No. 101076777, also funded by the European Union image. Mihyun Kang was supported in part by the Austrian Science Fund (FWF) [10.55776/I6502]. For the purpose of open access, the authors have applied a CC-BY public copyright licence to any Author Accepted Manuscript version arising from this submission.","isi":1,"publisher":"Wiley"},{"article_number":"101","_id":"18584","quality_controlled":"1","date_published":"2024-11-14T00:00:00Z","publisher":"IOP Publishing","doi":"10.3847/1538-4357/ad75fe","file":[{"file_size":13352667,"date_updated":"2024-12-10T08:18:53Z","file_name":"2024_AstrophysicalJournal_Suess.pdf","file_id":"18640","checksum":"dcd854acee73ce998d70a4ce634ead6d","success":1,"access_level":"open_access","relation":"main_file","creator":"dernst","content_type":"application/pdf","date_created":"2024-12-10T08:18:53Z"}],"acknowledgement":"K.A.S. thanks Shelly Meyett, the MegaScience Program Coordinator, for invaluable assistance designing WOPR 88967 and ensuring that this program was fully observed. This proposal was conceived of and developed at the International Space Science Institute (ISSI) in Bern, through ISSI International Team project #562. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The raw data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with JWST Cycle 2 GO program #4111, and this project has gratefully made use of a large number of public JWST programs in the A2744 field including JWST-GO-2641, JWST-ERS-1324, JWST-DD-2756, JWST-GO-2883, JWST-GO-3538, and JWST-GO-3516. Support for program JWST-GO-4111 was provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Associations of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555.\r\n\r\nThe Cosmic Dawn Center is funded by the Danish National Research Foundation (DNRF) under grant #140. P.D. acknowledges support from the NWO grant 016.VIDI.189.162 (\"ODIN\") and warmly thanks the European Commission's and University of Groningen's CO-FUND Rosalind Franklin program. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant 200020_207349. The work of C.C.W. is supported by NOIRLab, which is managed by the Association of Universities for Research in Astronomy (AURA) under a cooperative agreement with the National Science Foundation. T.B.M. was supported by a CIERA Fellowship. H.A. is supported by CNES, focused on the JWST mission, and by the Programme National Cosmology and Galaxies (PNCG) of CNRS/INSU with INP and IN2P3, co-funded by CEA and CNES. The BGU lensing group acknowledges support by grant No. 2020750 from the United States–Israel Binational Science Foundation (BSF) and grant No. 2109066 from the United States National Science Foundation (NSF); by the Ministry of Science & Technology, Israel; and by the Israel Science Foundation grant No. 864/23. Y.F. acknowledges support from JSPS KAKENHI grant No. JP22K21349 and JP23K13149. R.P. and D.M. acknowledge funding from JWST-GO-02561.013 and JWST-GO-04111.035.","isi":1,"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"publication_identifier":{"issn":["0004-637X"],"eissn":["1538-4357"]},"article_processing_charge":"Yes","department":[{"_id":"JoMa"}],"day":"14","title":"Medium bands, mega science: A JWST/NIRCam medium-band imaging survey of A2744","oa":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","language":[{"iso":"eng"}],"DOAJ_listed":"1","article_type":"original","citation":{"short":"K.A. Suess, J.R. Weaver, S.H. Price, R. Pan, B. Wang, R. Bezanson, G. Brammer, S.E. Cutler, I. Labbé, J. Leja, C.C. Williams, K.E. Whitaker, H. Atek, P. Dayal, A. De Graaff, R. Feldmann, M. Franx, Y. Fudamoto, S. Fujimoto, L.J. Furtak, A.D. Goulding, J.E. Greene, G. Khullar, V. Kokorev, M. Kriek, B. Lorenz, D. Marchesini, M.V. Maseda, J.J. Matthee, T.B. Miller, I. Mitsuhashi, L.A. Mowla, A. Muzzin, R.P. Naidu, T. Nanayakkara, E.J. Nelson, P.A. Oesch, D.J. Setton, H. Shipley, R. Smit, J.S. Spilker, P. Van Dokkum, A. Zitrin, Astrophysical Journal 976 (2024).","mla":"Suess, Katherine A., et al. “Medium Bands, Mega Science: A JWST/NIRCam Medium-Band Imaging Survey of A2744.” <i>Astrophysical Journal</i>, vol. 976, no. 1, 101, IOP Publishing, 2024, doi:<a href=\"https://doi.org/10.3847/1538-4357/ad75fe\">10.3847/1538-4357/ad75fe</a>.","ieee":"K. A. Suess <i>et al.</i>, “Medium bands, mega science: A JWST/NIRCam medium-band imaging survey of A2744,” <i>Astrophysical Journal</i>, vol. 976, no. 1. IOP Publishing, 2024.","ista":"Suess KA, Weaver JR, Price SH, Pan R, Wang B, Bezanson R, Brammer G, Cutler SE, Labbé I, Leja J, Williams CC, Whitaker KE, Atek H, Dayal P, De Graaff A, Feldmann R, Franx M, Fudamoto Y, Fujimoto S, Furtak LJ, Goulding AD, Greene JE, Khullar G, Kokorev V, Kriek M, Lorenz B, Marchesini D, Maseda MV, Matthee JJ, Miller TB, Mitsuhashi I, Mowla LA, Muzzin A, Naidu RP, Nanayakkara T, Nelson EJ, Oesch PA, Setton DJ, Shipley H, Smit R, Spilker JS, Van Dokkum P, Zitrin A. 2024. Medium bands, mega science: A JWST/NIRCam medium-band imaging survey of A2744. Astrophysical Journal. 976(1), 101.","ama":"Suess KA, Weaver JR, Price SH, et al. Medium bands, mega science: A JWST/NIRCam medium-band imaging survey of A2744. <i>Astrophysical Journal</i>. 2024;976(1). doi:<a href=\"https://doi.org/10.3847/1538-4357/ad75fe\">10.3847/1538-4357/ad75fe</a>","apa":"Suess, K. A., Weaver, J. R., Price, S. H., Pan, R., Wang, B., Bezanson, R., … Zitrin, A. (2024). Medium bands, mega science: A JWST/NIRCam medium-band imaging survey of A2744. <i>Astrophysical Journal</i>. IOP Publishing. <a href=\"https://doi.org/10.3847/1538-4357/ad75fe\">https://doi.org/10.3847/1538-4357/ad75fe</a>","chicago":"Suess, Katherine A., John R. Weaver, Sedona H. Price, Richard Pan, Bingjie Wang, Rachel Bezanson, Gabriel Brammer, et al. “Medium Bands, Mega Science: A JWST/NIRCam Medium-Band Imaging Survey of A2744.” <i>Astrophysical Journal</i>. IOP Publishing, 2024. <a href=\"https://doi.org/10.3847/1538-4357/ad75fe\">https://doi.org/10.3847/1538-4357/ad75fe</a>."},"external_id":{"arxiv":["2404.13132"],"isi":["001355710500001"]},"has_accepted_license":"1","status":"public","abstract":[{"lang":"eng","text":"In this paper, we describe the \"Medium Bands, Mega Science\" JWST Cycle 2 survey (JWST-GO-4111) and demonstrate the power of these data to reveal both the spatially integrated and spatially resolved properties of galaxies from the local Universe to the era of cosmic dawn. Executed in 2023 November, MegaScience obtained ∼30 arcmin2 of deep multiband NIRCam imaging centered on the z ∼ 0.3 A2744 cluster, including 11 medium-band filters and the two shortest-wavelength broadband filters, F070W and F090W. Together, MegaScience and the UNCOVER Cycle 1 treasury program provide a complete set of deep (∼28–30 magAB) images in all NIRCam medium- and broadband filters. This unique data set allows us to precisely constrain photometric redshifts, map stellar populations and dust attenuation for large samples of distant galaxies, and examine the connection between galaxy structures and formation histories. MegaScience also includes ∼17 arcmin2 of NIRISS parallel imaging in two broadband and four medium-band filters from 0.9 to 4.8 μm, expanding the footprint where robust spectral energy distribution (SED) fitting is possible. We provide example SEDs and multiband cutouts at a variety of redshifts, and use a catalog of JWST spectroscopic redshifts to show that MegaScience improves both the scatter and catastrophic outlier rate of photometric redshifts by factors of 2–3. Additionally, we demonstrate the spatially resolved science enabled by MegaScience by presenting maps of the [O iii] line emission and continuum emission in three spectroscopically confirmed z > 6 galaxies. We show that line emission in reionization-era galaxies can be clumpy, extended, and spatially offset from continuum emission, implying that galaxy assembly histories are complex even at these early epochs. We publicly release fully reduced mosaics and photometric catalogs for both the NIRCam primary and NIRISS parallel fields (jwst-uncover.github.io/megascience)."}],"type":"journal_article","publication":"Astrophysical Journal","date_created":"2024-11-24T23:01:48Z","oa_version":"Published Version","scopus_import":"1","OA_type":"gold","ddc":["520"],"arxiv":1,"date_updated":"2025-09-09T11:40:09Z","OA_place":"publisher","intvolume":"       976","author":[{"first_name":"Katherine A.","last_name":"Suess","full_name":"Suess, Katherine A."},{"full_name":"Weaver, John R.","first_name":"John R.","last_name":"Weaver"},{"first_name":"Sedona H.","last_name":"Price","full_name":"Price, Sedona H."},{"full_name":"Pan, Richard","first_name":"Richard","last_name":"Pan"},{"full_name":"Wang, Bingjie","first_name":"Bingjie","last_name":"Wang"},{"last_name":"Bezanson","first_name":"Rachel","full_name":"Bezanson, Rachel"},{"full_name":"Brammer, Gabriel","last_name":"Brammer","first_name":"Gabriel"},{"full_name":"Cutler, Sam E.","last_name":"Cutler","first_name":"Sam E."},{"full_name":"Labbé, Ivo","last_name":"Labbé","first_name":"Ivo"},{"first_name":"Joel","last_name":"Leja","full_name":"Leja, Joel"},{"first_name":"Christina C.","last_name":"Williams","full_name":"Williams, Christina C."},{"full_name":"Whitaker, Katherine E.","last_name":"Whitaker","first_name":"Katherine E."},{"full_name":"Atek, Hakim","last_name":"Atek","first_name":"Hakim"},{"full_name":"Dayal, Pratika","first_name":"Pratika","last_name":"Dayal"},{"full_name":"De Graaff, Anna","first_name":"Anna","last_name":"De Graaff"},{"full_name":"Feldmann, Robert","first_name":"Robert","last_name":"Feldmann"},{"full_name":"Franx, Marijn","last_name":"Franx","first_name":"Marijn"},{"last_name":"Fudamoto","first_name":"Yoshinobu","full_name":"Fudamoto, Yoshinobu"},{"full_name":"Fujimoto, Seiji","first_name":"Seiji","last_name":"Fujimoto"},{"full_name":"Furtak, Lukas J.","first_name":"Lukas J.","last_name":"Furtak"},{"first_name":"Andy D.","last_name":"Goulding","full_name":"Goulding, Andy D."},{"last_name":"Greene","first_name":"Jenny E.","full_name":"Greene, Jenny E."},{"full_name":"Khullar, Gourav","first_name":"Gourav","last_name":"Khullar"},{"first_name":"Vasily","last_name":"Kokorev","full_name":"Kokorev, Vasily"},{"full_name":"Kriek, Mariska","first_name":"Mariska","last_name":"Kriek"},{"last_name":"Lorenz","first_name":"Brian","full_name":"Lorenz, Brian"},{"last_name":"Marchesini","first_name":"Danilo","full_name":"Marchesini, Danilo"},{"last_name":"Maseda","first_name":"Michael V.","full_name":"Maseda, Michael V."},{"id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","first_name":"Jorryt J","orcid":"0000-0003-2871-127X","last_name":"Matthee"},{"first_name":"Tim B.","last_name":"Miller","full_name":"Miller, Tim B."},{"last_name":"Mitsuhashi","first_name":"Ikki","full_name":"Mitsuhashi, Ikki"},{"first_name":"Lamiya A.","last_name":"Mowla","full_name":"Mowla, Lamiya A."},{"last_name":"Muzzin","first_name":"Adam","full_name":"Muzzin, Adam"},{"full_name":"Naidu, Rohan P.","first_name":"Rohan P.","last_name":"Naidu"},{"first_name":"Themiya","last_name":"Nanayakkara","full_name":"Nanayakkara, Themiya"},{"last_name":"Nelson","first_name":"Erica J.","full_name":"Nelson, Erica J."},{"first_name":"Pascal A.","last_name":"Oesch","full_name":"Oesch, Pascal A."},{"last_name":"Setton","first_name":"David J.","full_name":"Setton, David J."},{"full_name":"Shipley, Heath","last_name":"Shipley","first_name":"Heath"},{"full_name":"Smit, Renske","last_name":"Smit","first_name":"Renske"},{"full_name":"Spilker, Justin S.","last_name":"Spilker","first_name":"Justin S."},{"first_name":"Pieter","last_name":"Van Dokkum","full_name":"Van Dokkum, Pieter"},{"full_name":"Zitrin, Adi","last_name":"Zitrin","first_name":"Adi"}],"month":"11","volume":976,"issue":"1","publication_status":"published","file_date_updated":"2024-12-10T08:18:53Z","year":"2024"},{"publication_identifier":{"eissn":["1365-2966"],"issn":["0035-8711"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"Yes","department":[{"_id":"JoMa"}],"day":"01","oa":1,"title":"JWST FRESCO: A comprehensive census of H β + [O iii] emitters at 6.8 < z < 9.0 in the GOODS fields","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","quality_controlled":"1","_id":"18585","date_published":"2024-11-01T00:00:00Z","publisher":"Oxford University Press","acknowledgement":"The authors thank the anonymous referee for comments and suggestions which improved this paper. RAM thanks R. Kannan for sharing emission line luminosities from THESAN and H. Katz for similar data from an early version of the SPHINX20 data release (we use the final data release in this paper). The authors thank the CONGRESS team for proposing and designing their program with a zero exclusive access period.\r\nRAM, PA, ACP, and AW acknowledge support from the Swiss National Science Foundation (SNSF) through project grant 200020_207349. PA, AW, EG, and MX acknowledge support from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072. YF acknowledges support by JSPS KAKENHI grant number JP22K21349 and JP23K13149. RPN acknowledges support for this work provided by NASA through the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. MS acknowledges support from the European Research Commission Grant 101088789 (SFEER), from the CIDEGENT/2021/059 grant by Generalitat Valenciana, and from project PID2019-109592GB-I00/AEI/10.13039/501100011033 by the Spanish Ministerio de Ciencia e Innovación - Agencia Estatal de Investigación. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant no. 140. Cloud-based data processing and file storage for this work is provided by the AWS Cloud Credits for Research program. RJB and MS acknowledges support from NWO grant TOP1.16.057.\r\nThis work is based on observations made with the NASA/ESA/CSA JWST. The raw data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with JWST Cycle 1 GO program #1895. Support for program JWST-GO-1895 was provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Associations of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555.","isi":1,"doi":"10.1093/mnras/stae2353","file":[{"file_size":29476699,"date_updated":"2024-12-03T12:52:13Z","file_id":"18613","file_name":"2024_MonthlyNRoyalAstronSoc_Meyer.pdf","success":1,"checksum":"efe0ce3580e01459f3be78eb111b35a9","access_level":"open_access","relation":"main_file","creator":"dernst","date_created":"2024-12-03T12:52:13Z","content_type":"application/pdf"}],"page":"1067-1094","author":[{"full_name":"Meyer, R. A.","first_name":"R. A.","last_name":"Meyer"},{"full_name":"Oesch, P. A.","first_name":"P. A.","last_name":"Oesch"},{"first_name":"E.","last_name":"Giovinazzo","full_name":"Giovinazzo, E."},{"first_name":"A.","last_name":"Weibel","full_name":"Weibel, A."},{"last_name":"Brammer","first_name":"G.","full_name":"Brammer, G."},{"id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","last_name":"Matthee","first_name":"Jorryt J","orcid":"0000-0003-2871-127X"},{"full_name":"Naidu, R. P.","first_name":"R. P.","last_name":"Naidu"},{"full_name":"Bouwens, R. J.","last_name":"Bouwens","first_name":"R. J."},{"full_name":"Chisholm, J.","last_name":"Chisholm","first_name":"J."},{"full_name":"Covelo-Paz, A.","last_name":"Covelo-Paz","first_name":"A."},{"last_name":"Fudamoto","first_name":"Y.","full_name":"Fudamoto, Y."},{"last_name":"Maseda","first_name":"M.","full_name":"Maseda, M."},{"full_name":"Nelson, E.","last_name":"Nelson","first_name":"E."},{"last_name":"Shivaei","first_name":"I.","full_name":"Shivaei, I."},{"full_name":"Xiao, M.","last_name":"Xiao","first_name":"M."},{"full_name":"Herard-Demanche, T.","last_name":"Herard-Demanche","first_name":"T."},{"full_name":"Illingworth, G. D.","first_name":"G. D.","last_name":"Illingworth"},{"last_name":"Kerutt","first_name":"J.","full_name":"Kerutt, J."},{"id":"9a9394cb-3200-11ee-973b-f5ba2a8b16e4","full_name":"Kramarenko, Ivan","first_name":"Ivan","orcid":"0000-0001-5346-6048","last_name":"Kramarenko"},{"full_name":"Labbe, I.","first_name":"I.","last_name":"Labbe"},{"full_name":"Leonova, E.","last_name":"Leonova","first_name":"E."},{"last_name":"Magee","first_name":"D.","full_name":"Magee, D."},{"last_name":"Matharu","first_name":"J.","full_name":"Matharu, J."},{"last_name":"Prieto Lyon","first_name":"G.","full_name":"Prieto Lyon, G."},{"first_name":"N.","last_name":"Reddy","full_name":"Reddy, N."},{"full_name":"Schaerer, D.","last_name":"Schaerer","first_name":"D."},{"first_name":"A.","last_name":"Shapley","full_name":"Shapley, A."},{"full_name":"Stefanon, M.","last_name":"Stefanon","first_name":"M."},{"last_name":"Wozniak","first_name":"M. A.","full_name":"Wozniak, M. A."},{"full_name":"Wuyts, S.","first_name":"S.","last_name":"Wuyts"}],"month":"11","issue":"1","volume":535,"file_date_updated":"2024-12-03T12:52:13Z","publication_status":"published","year":"2024","DOAJ_listed":"1","citation":{"chicago":"Meyer, R. A., P. A. Oesch, E. Giovinazzo, A. Weibel, G. Brammer, Jorryt J Matthee, R. P. Naidu, et al. “JWST FRESCO: A Comprehensive Census of H β + [O Iii] Emitters at 6.8 &#60; z &#60; 9.0 in the GOODS Fields.” <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/mnras/stae2353\">https://doi.org/10.1093/mnras/stae2353</a>.","ieee":"R. A. Meyer <i>et al.</i>, “JWST FRESCO: A comprehensive census of H β + [O iii] emitters at 6.8 &#60; z &#60; 9.0 in the GOODS fields,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 535, no. 1. Oxford University Press, pp. 1067–1094, 2024.","ista":"Meyer RA, Oesch PA, Giovinazzo E, Weibel A, Brammer G, Matthee JJ, Naidu RP, Bouwens RJ, Chisholm J, Covelo-Paz A, Fudamoto Y, Maseda M, Nelson E, Shivaei I, Xiao M, Herard-Demanche T, Illingworth GD, Kerutt J, Kramarenko I, Labbe I, Leonova E, Magee D, Matharu J, Prieto Lyon G, Reddy N, Schaerer D, Shapley A, Stefanon M, Wozniak MA, Wuyts S. 2024. JWST FRESCO: A comprehensive census of H β + [O iii] emitters at 6.8 &#60; z &#60; 9.0 in the GOODS fields. Monthly Notices of the Royal Astronomical Society. 535(1), 1067–1094.","ama":"Meyer RA, Oesch PA, Giovinazzo E, et al. JWST FRESCO: A comprehensive census of H β + [O iii] emitters at 6.8 &#60; z &#60; 9.0 in the GOODS fields. <i>Monthly Notices of the Royal Astronomical Society</i>. 2024;535(1):1067-1094. doi:<a href=\"https://doi.org/10.1093/mnras/stae2353\">10.1093/mnras/stae2353</a>","apa":"Meyer, R. A., Oesch, P. A., Giovinazzo, E., Weibel, A., Brammer, G., Matthee, J. J., … Wuyts, S. (2024). JWST FRESCO: A comprehensive census of H β + [O iii] emitters at 6.8 &#60; z &#60; 9.0 in the GOODS fields. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/mnras/stae2353\">https://doi.org/10.1093/mnras/stae2353</a>","short":"R.A. Meyer, P.A. Oesch, E. Giovinazzo, A. Weibel, G. Brammer, J.J. Matthee, R.P. Naidu, R.J. Bouwens, J. Chisholm, A. Covelo-Paz, Y. Fudamoto, M. Maseda, E. Nelson, I. Shivaei, M. Xiao, T. Herard-Demanche, G.D. Illingworth, J. Kerutt, I. Kramarenko, I. Labbe, E. Leonova, D. Magee, J. Matharu, G. Prieto Lyon, N. Reddy, D. Schaerer, A. Shapley, M. Stefanon, M.A. Wozniak, S. Wuyts, Monthly Notices of the Royal Astronomical Society 535 (2024) 1067–1094.","mla":"Meyer, R. A., et al. “JWST FRESCO: A Comprehensive Census of H β + [O Iii] Emitters at 6.8 &#60; z &#60; 9.0 in the GOODS Fields.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 535, no. 1, Oxford University Press, 2024, pp. 1067–94, doi:<a href=\"https://doi.org/10.1093/mnras/stae2353\">10.1093/mnras/stae2353</a>."},"article_type":"original","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"We present the census of Hβ+[OIII] 4960,5008 Åemitters at 6.8<z<9.0 from the JWST FRESCO survey over 124 arcmin2 in the GOODS-North and GOODS-South fields. Our unbiased spectroscopic search results in 137 spectroscopically-confirmed galaxies at 6.8<z<9.0 with observed [OIII] fluxes f[OIII]≳1×10−18 ergs s−1 cm−2. The rest-frame optical line ratios of the median stacked spectrum (median MUV=−19.65+0.59−1.05) indicate negligible dust attenuation, low metallicity (12+log(O/H)=7.2−7.7) and a high ionisation parameter log10U≃−2.5. We find a factor ×1.3 difference in the number density of 6.8<z<9.0 galaxies between GOODS-South and GOODS-North, which is caused by a single overdensity at 7.0<z<7.2 in GOODS-North. The bright end of the UV luminosity function of spectroscopically-confirmed [OIII] emitters is in good agreement with HST dropout-selected samples. Discrepancies between the observed [OIII] LF, [OIII]/UV ratio and [OIII] equivalent widths, and that predicted by theoretical models, suggest burstier star-formation histories and/or more heterogeneous metallicity and ionising conditions in z>7 galaxies. We report a rapid decline of the [OIII] luminosity density at z≳6−7 which cannot be explained by the evolution of the cosmic star-formation rate density. Finally we find that FRESCO detects in only 2h galaxies likely accounting for ∼10−20% of the ionising budget at z=7−8 (assuming an escape fraction of 10%), raising the prospect of directly detecting a significant fraction of the sources of reionisation with JWST."}],"external_id":{"isi":["001348009500001"]},"has_accepted_license":"1","status":"public","publication":"Monthly Notices of the Royal Astronomical Society","scopus_import":"1","oa_version":"Published Version","date_created":"2024-11-24T23:01:49Z","type":"journal_article","OA_type":"gold","date_updated":"2025-09-08T14:47:58Z","ddc":["520"],"OA_place":"publisher","intvolume":"       535"},{"abstract":[{"lang":"eng","text":"We prove the Central Limit Theorem and superpolynomial mixing for environment\r\nviewed from the particle process in quasi periodic Diophantine random environment. The main\r\ningredients are smoothness estimates for the solution of the Poisson equation and local limit asymptotics for certain accelerated walks."}],"status":"public","external_id":{"arxiv":["2404.11700"],"isi":["001440992000003"]},"oa_version":"Preprint","date_created":"2024-11-24T23:01:49Z","scopus_import":"1","publication":"Alea","main_file_link":[{"open_access":"1","url":" https://doi.org/10.48550/arXiv.2404.11700"}],"type":"journal_article","citation":{"chicago":"CZUDEK, Klaudiusz S, and Dmitry Dolgopyat. “The Central Limit Theorem and Rate of Mixing for Simple Random Walks on the Circle.” <i>Alea</i>. Instituto Nacional de Matematica Pura e Aplicada, 2024. <a href=\"https://doi.org/10.30757/ALEA.V21-70\">https://doi.org/10.30757/ALEA.V21-70</a>.","apa":"CZUDEK, K. S., &#38; Dolgopyat, D. (2024). The central limit theorem and rate of mixing for simple random walks on the circle. <i>Alea</i>. Instituto Nacional de Matematica Pura e Aplicada. <a href=\"https://doi.org/10.30757/ALEA.V21-70\">https://doi.org/10.30757/ALEA.V21-70</a>","ama":"CZUDEK KS, Dolgopyat D. The central limit theorem and rate of mixing for simple random walks on the circle. <i>Alea</i>. 2024;21(2):1853-1865. doi:<a href=\"https://doi.org/10.30757/ALEA.V21-70\">10.30757/ALEA.V21-70</a>","ista":"CZUDEK KS, Dolgopyat D. 2024. The central limit theorem and rate of mixing for simple random walks on the circle. Alea. 21(2), 1853–1865.","ieee":"K. S. CZUDEK and D. Dolgopyat, “The central limit theorem and rate of mixing for simple random walks on the circle,” <i>Alea</i>, vol. 21, no. 2. Instituto Nacional de Matematica Pura e Aplicada, pp. 1853–1865, 2024.","mla":"CZUDEK, Klaudiusz S., and Dmitry Dolgopyat. “The Central Limit Theorem and Rate of Mixing for Simple Random Walks on the Circle.” <i>Alea</i>, vol. 21, no. 2, Instituto Nacional de Matematica Pura e Aplicada, 2024, pp. 1853–65, doi:<a href=\"https://doi.org/10.30757/ALEA.V21-70\">10.30757/ALEA.V21-70</a>.","short":"K.S. CZUDEK, D. Dolgopyat, Alea 21 (2024) 1853–1865."},"ec_funded":1,"article_type":"original","language":[{"iso":"eng"}],"date_updated":"2025-09-08T14:48:42Z","arxiv":1,"intvolume":"        21","OA_place":"repository","project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413"}],"OA_type":"green","author":[{"full_name":"Czudek, Klaudiusz S","id":"5c0e116e-803f-11ed-ab7e-90d572405f20","last_name":"Czudek","first_name":"Klaudiusz S"},{"full_name":"Dolgopyat, Dmitry","first_name":"Dmitry","last_name":"Dolgopyat"}],"page":"1853-1865","publication_status":"published","year":"2024","month":"11","issue":"2","volume":21,"_id":"18586","date_published":"2024-11-01T00:00:00Z","quality_controlled":"1","publisher":"Instituto Nacional de Matematica Pura e Aplicada","isi":1,"acknowledgement":"ents. The authors are grateful to Agnieszka Zelerowicz and the anonymous referee\r\nfor useful comments. The first author is grateful to Minsung Kim for providing some references.\r\nThe first author has been supported by the European Union Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant Agreement No. 101034413. The second author has been supported by the NSF grant DMS 2246983.","doi":"10.30757/ALEA.V21-70","publication_identifier":{"issn":["1980-0436"]},"article_processing_charge":"No","oa":1,"title":"The central limit theorem and rate of mixing for simple random walks on the circle","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"VaKa"}],"day":"01"},{"_id":"18587","date_published":"2024-12-01T00:00:00Z","quality_controlled":"1","publisher":"Springer Nature","isi":1,"file":[{"file_size":967252,"file_id":"18614","file_name":"2024_LabAnimal_Lauwereyns.pdf","date_updated":"2024-12-03T14:07:04Z","success":1,"checksum":"67fc140f761581a291591f075e49b88d","access_level":"open_access","creator":"dernst","relation":"main_file","content_type":"application/pdf","date_created":"2024-12-03T14:07:04Z"}],"doi":"10.1038/s41684-024-01476-2","acknowledgement":"This publication is based upon work from the Ethics Crossover Group within the COST Action IMPROVE (“3Rs concepts to improve the quality of biomedical science”), CA21139, supported by COST (European Cooperation in Science and Technology). We acknowledge the input and advice from Dr. Susanna Louhimies.","publication_identifier":{"eissn":["1548-4475"],"issn":["0093-7355"]},"tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"article_processing_charge":"No","oa":1,"title":"Toward a common interpretation of the 3Rs principles in animal research","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","department":[{"_id":"PreCl"}],"day":"01","abstract":[{"text":"Many scientific breakthroughs have depended on animal research, yet the ethical concerns surrounding the use of animals in experimentation have long prompted discussions about humane treatment and responsible scientific practice. First articulated by Russell and Burch, the 3Rs Principles of Replacement, Reduction, and Refinement have gained widespread recognition as basic guidelines for animal research. Over time, the 3Rs have transcended the research community, influencing policy decisions, animal welfare advocacy and public perception of animal experimentation. Despite their broad acceptance, interpretations of the 3Rs vary substantially, shaping statutory frameworks at various levels, with both technical and practical impacts.","lang":"eng"}],"has_accepted_license":"1","status":"public","external_id":{"isi":["001355264100001"],"pmid":["39548348"]},"date_created":"2024-11-24T23:01:49Z","scopus_import":"1","oa_version":"Published Version","publication":"Lab Animal","type":"journal_article","article_type":"letter_note","citation":{"chicago":"Lauwereyns, Jan, Jeffrey Bajramovic, Bettina Bert, Samuel Camenzind, Joery De Kock, Alisa Elezović, Sevilay Erden, et al. “Toward a Common Interpretation of the 3Rs Principles in Animal Research.” <i>Lab Animal</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1038/s41684-024-01476-2\">https://doi.org/10.1038/s41684-024-01476-2</a>.","short":"J. Lauwereyns, J. Bajramovic, B. Bert, S. Camenzind, J. De Kock, A. Elezović, S. Erden, F. Gonzalez-Uarquin, Y.I. Ulman, O.I. Hoffmann, M. Kitsara, N. Kostomitsopoulos, W. Neuhaus, B. Petit-Demouliere, S. Pollo, B. Riso, S. Schober, A. Sotiropoulos, A. Thomas, A. Vitale, D. Wilflingseder, A. Ahluwalia, Lab Animal 53 (2024) 347–350.","mla":"Lauwereyns, Jan, et al. “Toward a Common Interpretation of the 3Rs Principles in Animal Research.” <i>Lab Animal</i>, vol. 53, Springer Nature, 2024, pp. 347–50, doi:<a href=\"https://doi.org/10.1038/s41684-024-01476-2\">10.1038/s41684-024-01476-2</a>.","ista":"Lauwereyns J, Bajramovic J, Bert B, Camenzind S, De Kock J, Elezović A, Erden S, Gonzalez-Uarquin F, Ulman YI, Hoffmann OI, Kitsara M, Kostomitsopoulos N, Neuhaus W, Petit-Demouliere B, Pollo S, Riso B, Schober S, Sotiropoulos A, Thomas A, Vitale A, Wilflingseder D, Ahluwalia A. 2024. Toward a common interpretation of the 3Rs principles in animal research. Lab Animal. 53, 347–350.","ieee":"J. Lauwereyns <i>et al.</i>, “Toward a common interpretation of the 3Rs principles in animal research,” <i>Lab Animal</i>, vol. 53. Springer Nature, pp. 347–350, 2024.","ama":"Lauwereyns J, Bajramovic J, Bert B, et al. Toward a common interpretation of the 3Rs principles in animal research. <i>Lab Animal</i>. 2024;53:347-350. doi:<a href=\"https://doi.org/10.1038/s41684-024-01476-2\">10.1038/s41684-024-01476-2</a>","apa":"Lauwereyns, J., Bajramovic, J., Bert, B., Camenzind, S., De Kock, J., Elezović, A., … Ahluwalia, A. (2024). Toward a common interpretation of the 3Rs principles in animal research. <i>Lab Animal</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41684-024-01476-2\">https://doi.org/10.1038/s41684-024-01476-2</a>"},"language":[{"iso":"eng"}],"date_updated":"2025-09-08T14:50:31Z","ddc":["570"],"intvolume":"        53","OA_place":"publisher","OA_type":"hybrid","author":[{"last_name":"Lauwereyns","first_name":"Jan","full_name":"Lauwereyns, Jan"},{"full_name":"Bajramovic, Jeffrey","last_name":"Bajramovic","first_name":"Jeffrey"},{"full_name":"Bert, Bettina","last_name":"Bert","first_name":"Bettina"},{"full_name":"Camenzind, Samuel","first_name":"Samuel","last_name":"Camenzind"},{"last_name":"De Kock","first_name":"Joery","full_name":"De Kock, Joery"},{"first_name":"Alisa","last_name":"Elezović","full_name":"Elezović, Alisa"},{"last_name":"Erden","first_name":"Sevilay","full_name":"Erden, Sevilay"},{"first_name":"Fernando","last_name":"Gonzalez-Uarquin","full_name":"Gonzalez-Uarquin, Fernando"},{"full_name":"Ulman, Yesim Isil","last_name":"Ulman","first_name":"Yesim Isil"},{"first_name":"Orsolya Ivett","last_name":"Hoffmann","full_name":"Hoffmann, Orsolya Ivett"},{"first_name":"Maria","last_name":"Kitsara","full_name":"Kitsara, Maria"},{"last_name":"Kostomitsopoulos","first_name":"Nikolaos","full_name":"Kostomitsopoulos, Nikolaos"},{"full_name":"Neuhaus, Winfried","last_name":"Neuhaus","first_name":"Winfried"},{"last_name":"Petit-Demouliere","first_name":"Benoit","full_name":"Petit-Demouliere, Benoit"},{"full_name":"Pollo, Simone","first_name":"Simone","last_name":"Pollo"},{"first_name":"Brígida","last_name":"Riso","full_name":"Riso, Brígida"},{"last_name":"Schober","first_name":"Sophie","id":"80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8","full_name":"Schober, Sophie"},{"first_name":"Athanassia","last_name":"Sotiropoulos","full_name":"Sotiropoulos, Athanassia"},{"last_name":"Thomas","first_name":"Aurélie","full_name":"Thomas, Aurélie"},{"full_name":"Vitale, Augusto","first_name":"Augusto","last_name":"Vitale"},{"first_name":"Doris","last_name":"Wilflingseder","full_name":"Wilflingseder, Doris"},{"last_name":"Ahluwalia","first_name":"Arti","full_name":"Ahluwalia, Arti"}],"page":"347-350","pmid":1,"publication_status":"published","file_date_updated":"2024-12-03T14:07:04Z","year":"2024","month":"12","volume":53},{"page":"61","alternative_title":["ISTA Master's Thesis"],"acknowledged_ssus":[{"_id":"NanoFab"},{"_id":"M-Shop"}],"author":[{"id":"2a69ab4b-896a-11ed-bdf8-cb8641cf2b21","full_name":"Mweka, Cecelia N","last_name":"Mweka","first_name":"Cecelia N"}],"month":"11","year":"2024","publication_status":"published","file_date_updated":"2024-12-13T11:30:53Z","citation":{"mla":"Mweka, Cecelia N. <i>Non Equilibrium Dynamics of Driven Individual Particles and 3D Printing across Scales</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:18588\">10.15479/at:ista:18588</a>.","short":"C.N. Mweka, Non Equilibrium Dynamics of Driven Individual Particles and 3D Printing across Scales, Institute of Science and Technology Austria, 2024.","apa":"Mweka, C. N. (2024). <i>Non equilibrium dynamics of driven individual particles and 3D printing across scales</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:18588\">https://doi.org/10.15479/at:ista:18588</a>","ista":"Mweka CN. 2024. Non equilibrium dynamics of driven individual particles and 3D printing across scales. Institute of Science and Technology Austria.","ama":"Mweka CN. Non equilibrium dynamics of driven individual particles and 3D printing across scales. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:18588\">10.15479/at:ista:18588</a>","ieee":"C. N. Mweka, “Non equilibrium dynamics of driven individual particles and 3D printing across scales,” Institute of Science and Technology Austria, 2024.","chicago":"Mweka, Cecelia N. “Non Equilibrium Dynamics of Driven Individual Particles and 3D Printing across Scales.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:18588\">https://doi.org/10.15479/at:ista:18588</a>."},"language":[{"iso":"eng"}],"oa_version":"Published Version","date_created":"2024-11-27T09:12:02Z","type":"dissertation","corr_author":"1","abstract":[{"text":"This thesis is an experimental work about two distinct research projects that evolved from a single project: non-equilibrium dynamics of an acoustically vibrated particle and microfabrication of particles with nano-scale 3D printing. The first project explores non equilibrium dynamics of a particle driven by ultrasonic vibrations. We design an experimental system consisting of an electromechanical vibration scheme to drive the particle’s vibrations and an imaging scheme to track its trajectories. We study the trajectories to determine how the particle’s dynamics evolve under the driven conditions, considering out of equilibrium systems in the context of equilibrium statistical mechanics. Using a Langevin framework and the Boltzmann factor, we characterize the particle’s dynamics as complex; the particle motion\r\nis not purely diffusive. We extract physical parameters like spring constant, effective temperature, damping coefficient and resonance frequency.\r\n\r\nIn the second project, we explore and develop techniques in the design and microfabrication of particles across scales. Microfabrication involves building structures at the micron or submicron scale. These designed miniaturized patterns, objects, or devices are useful in biophysics, pharmacology, medical biology, and nanotechnology. We specifically apply two-photon polymerization, a form of 3D nano printing. We print millimetric particles, characterizing different designs to evaluate and showcase the resolution, aspect ratio integrity and print quality of the printing process. We also design and fabricate a microsensor to deflect under applicable force of order 0.1 pN. We present fundamental concepts needed to design the microsensor, showcasing 3D printing at considerably smaller scales down to the µm or below.","lang":"eng"}],"has_accepted_license":"1","status":"public","OA_place":"publisher","date_updated":"2026-04-07T12:42:13Z","ddc":["530"],"article_processing_charge":"No","publication_identifier":{"issn":["2791-4585"]},"day":"29","department":[{"_id":"GradSch"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa":1,"title":"Non equilibrium dynamics of driven individual particles and 3D printing across scales","_id":"18588","date_published":"2024-11-29T00:00:00Z","supervisor":[{"full_name":"Waitukaitis, Scott R","id":"3A1FFC16-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2299-3176","first_name":"Scott R","last_name":"Waitukaitis"},{"full_name":"Palacci, Jérémie A","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","last_name":"Palacci","orcid":"0000-0002-7253-9465","first_name":"Jérémie A"}],"file":[{"access_level":"open_access","creator":"cmweka","relation":"main_file","date_created":"2024-11-28T12:50:32Z","content_type":"application/pdf","file_size":3836671,"file_id":"18597","file_name":"Cecelia Mweka Master Thesis.pdf","date_updated":"2024-11-28T12:50:32Z","checksum":"054ed7a5e5ae6e7220e6bb37ea57a3c3","success":1},{"date_created":"2024-11-28T12:51:43Z","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","access_level":"closed","relation":"source_file","creator":"cmweka","date_updated":"2024-12-13T11:30:53Z","file_name":"Cecelia Mweka Master Thesis.docx","file_id":"18598","checksum":"7d7d9299f090d83e628d65d93116e8c2","file_size":7068210}],"doi":"10.15479/at:ista:18588","acknowledgement":"I would like to acknowledge Scott Waitukaitis and Jérémie Palacci, for their supervision, and their extensive support of my learning. \r\n\r\nFor the beautiful characterization images used in this work, I would like to thank Dr. Daniel Grober, Samuel Hajek and Felix Pertl.\r\n\r\nThe Palacci group, particularly Malina Strugaru and Dan Grober, for their continuous guidance in decoding and following my streams of thought.\r\n\r\nTo the Waitukaitis group, for helping me find my footing in science, and making me feel at\r\nhome.\r\n\r\nTo the Nanofabrication Facility (NFF) at ISTA, for training me in significant aspects of my research. The MIBA Facility, and particularly Todor Asenov for consistently picking up the phone for my machining and designing needs.\r\n\r\nTo my friends, Mariana, Lenka, Aaron, Rebecca, Eavan who provided an ear, wine, and a lot more when I needed to vent, talk through my crises as well as experiment. For the walks, for the coffees, for reading through my work and providing edits, for dinners to take me out of blocks and binds and for cheering me on when it felt insurmountable. \r\n\r\nFinally, I am grateful to Griff and Fletcher, whose music helped me through several blocks, especially with my writing.\r\n\r\nMy science would not have been possible without the guidance, support and contributions of\r\nall these people, and more.","degree_awarded":"MS","publisher":"Institute of Science and Technology Austria"},{"isi":1,"file":[{"content_type":"application/pdf","date_created":"2024-12-03T11:08:09Z","creator":"dernst","relation":"main_file","access_level":"open_access","success":1,"checksum":"a11feea4b1677df76b632eca04bfc1dd","file_name":"2024_MolecularPlant_Kralova.pdf","file_id":"18612","date_updated":"2024-12-03T11:08:09Z","file_size":3308945}],"doi":"10.1016/j.molp.2024.11.001","acknowledgement":"We dedicate this paper to the deceased Petr Galuszka for his inspiration and support of our project. We thank Prof. Peter Hedden for constructive criticism of the manuscript and English editing. No conflict of interest is declared.","publisher":"Elsevier","quality_controlled":"1","_id":"18596","date_published":"2024-12-02T00:00:00Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","oa":1,"title":"A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis","day":"02","department":[{"_id":"JiFr"},{"_id":"EvBe"}],"article_processing_charge":"Yes (in subscription journal)","publication_identifier":{"issn":["1674-2052"]},"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"intvolume":"        17","OA_place":"publisher","date_updated":"2025-09-08T14:46:45Z","ddc":["580"],"OA_type":"hybrid","scopus_import":"1","publication":"Molecular Plant","oa_version":"Published Version","date_created":"2024-11-28T11:13:35Z","type":"journal_article","abstract":[{"lang":"eng","text":"Hormone perception and signaling pathways have a fundamental regulatory function in the physiological processes of plants. Cytokinins, a class of plant hormones, regulate cell division and meristem maintenance. The cytokinin signaling pathway is well established in the model plant Arabidopsis thaliana. Several negative feedback mechanisms, tightly controlling cytokinin signaling output, have been described previously. In this study, we identified a new feedback mechanism executed through alternative splicing of the cytokinin receptor AHK4/CRE1. A novel splicing variant named CRE1int7 results from seventh intron retention, introducing a premature termination codon in the transcript. We showed that CRE1int7 is translated in planta into a truncated receptor lacking the C-terminal receiver domain essential for signal transduction. CRE1int7 can bind cytokinin but cannot activate the downstream cascade. We present a novel negative feedback mechanism of the cytokinin signaling pathway, facilitated by a decoy receptor that can inactivate canonical cytokinin receptors via dimerization and compete with them for ligand binding. Ensuring proper plant growth and development requires precise control of the cytokinin signaling pathway at several levels. CRE1int7 represents a so-far unknown mechanism for fine-tuning the cytokinin signaling pathway in Arabidopsis."}],"external_id":{"isi":["001373778300001"],"pmid":["39501563"]},"has_accepted_license":"1","status":"public","citation":{"ama":"Králová M, Kubalová I, Hajný J, et al. A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis. <i>Molecular Plant</i>. 2024;17(12):1850-1865. doi:<a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">10.1016/j.molp.2024.11.001</a>","ieee":"M. Králová <i>et al.</i>, “A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis,” <i>Molecular Plant</i>, vol. 17, no. 12. Elsevier, pp. 1850–1865, 2024.","ista":"Králová M, Kubalová I, Hajný J, Kubiasova K, Vagaská K, Ge Z, Gallei MC, Semerádová H, Kuchařová A, Hönig M, Monzer A, Kovačik M, Friml J, Novák O, Benková E, Ikeda Y, Zalabák D. 2024. A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis. Molecular Plant. 17(12), 1850–1865.","apa":"Králová, M., Kubalová, I., Hajný, J., Kubiasova, K., Vagaská, K., Ge, Z., … Zalabák, D. (2024). A decoy receptor derived from alternative splicing fine-tunes cytokinin signaling in Arabidopsis. <i>Molecular Plant</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">https://doi.org/10.1016/j.molp.2024.11.001</a>","short":"M. Králová, I. Kubalová, J. Hajný, K. Kubiasova, K. Vagaská, Z. Ge, M.C. Gallei, H. Semerádová, A. Kuchařová, M. Hönig, A. Monzer, M. Kovačik, J. Friml, O. Novák, E. Benková, Y. Ikeda, D. Zalabák, Molecular Plant 17 (2024) 1850–1865.","mla":"Králová, Michaela, et al. “A Decoy Receptor Derived from Alternative Splicing Fine-Tunes Cytokinin Signaling in Arabidopsis.” <i>Molecular Plant</i>, vol. 17, no. 12, Elsevier, 2024, pp. 1850–65, doi:<a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">10.1016/j.molp.2024.11.001</a>.","chicago":"Králová, Michaela, Ivona Kubalová, Jakub Hajný, Karolina Kubiasova, Karolína Vagaská, Zengxiang Ge, Michelle C Gallei, et al. “A Decoy Receptor Derived from Alternative Splicing Fine-Tunes Cytokinin Signaling in Arabidopsis.” <i>Molecular Plant</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.molp.2024.11.001\">https://doi.org/10.1016/j.molp.2024.11.001</a>."},"article_type":"original","language":[{"iso":"eng"}],"year":"2024","file_date_updated":"2024-12-03T11:08:09Z","publication_status":"published","issue":"12","volume":17,"month":"12","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"author":[{"last_name":"Králová","first_name":"Michaela","full_name":"Králová, Michaela"},{"last_name":"Kubalová","first_name":"Ivona","full_name":"Kubalová, Ivona"},{"full_name":"Hajný, Jakub","first_name":"Jakub","last_name":"Hajný"},{"id":"946011F4-3E71-11EA-860B-C7A73DDC885E","full_name":"Kubiasova, Karolina","last_name":"Kubiasova","first_name":"Karolina","orcid":"0000-0001-5630-9419"},{"last_name":"Vagaská","first_name":"Karolína","full_name":"Vagaská, Karolína"},{"first_name":"Zengxiang","orcid":"0000-0001-9381-3577","last_name":"Ge","id":"f43371a3-09ff-11eb-8013-bd0c6a2f6de8","full_name":"Ge, Zengxiang"},{"full_name":"Gallei, Michelle C","id":"35A03822-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1286-7368","first_name":"Michelle C","last_name":"Gallei"},{"full_name":"Semerádová, Hana","id":"42FE702E-F248-11E8-B48F-1D18A9856A87","last_name":"Semerádová","first_name":"Hana"},{"full_name":"Kuchařová, Anna","first_name":"Anna","last_name":"Kuchařová"},{"full_name":"Hönig, Martin","first_name":"Martin","last_name":"Hönig"},{"last_name":"Monzer","first_name":"Aline","id":"2DB5D88C-D7B3-11E9-B8FD-7907E6697425","full_name":"Monzer, Aline"},{"full_name":"Kovačik, Martin","last_name":"Kovačik","first_name":"Martin"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Novák, Ondřej","last_name":"Novák","first_name":"Ondřej"},{"id":"38F4F166-F248-11E8-B48F-1D18A9856A87","full_name":"Benková, Eva","last_name":"Benková","first_name":"Eva","orcid":"0000-0002-8510-9739"},{"full_name":"Ikeda, Yoshihisa","last_name":"Ikeda","first_name":"Yoshihisa"},{"first_name":"David","last_name":"Zalabák","full_name":"Zalabák, David"}],"pmid":1,"page":"1850-1865"}]