[{"status":"public","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"issue":"9","citation":{"ieee":"J. Taboada-Gutiérrez <i>et al.</i>, “Unveiling the mechanism of phonon-polariton damping in α‑MoO3,” <i>ACS Photonics</i>, vol. 11, no. 9. American Chemical Society, pp. 3570–3577, 2024.","chicago":"Taboada-Gutiérrez, Javier, Yixi Zhou, Ana I.F. Tresguerres-Mata, Christian Lanza, Abel Martínez-Suárez, Gonzalo Álvarez-Pérez, Jiahua Duan, et al. “Unveiling the Mechanism of Phonon-Polariton Damping in Α‑MoO3.” <i>ACS Photonics</i>. American Chemical Society, 2024. <a href=\"https://doi.org/10.1021/acsphotonics.4c00485\">https://doi.org/10.1021/acsphotonics.4c00485</a>.","ama":"Taboada-Gutiérrez J, Zhou Y, Tresguerres-Mata AIF, et al. Unveiling the mechanism of phonon-polariton damping in α‑MoO3. <i>ACS Photonics</i>. 2024;11(9):3570-3577. doi:<a href=\"https://doi.org/10.1021/acsphotonics.4c00485\">10.1021/acsphotonics.4c00485</a>","short":"J. Taboada-Gutiérrez, Y. Zhou, A.I.F. Tresguerres-Mata, C. Lanza, A. Martínez-Suárez, G. Álvarez-Pérez, J. Duan, J.I. Martín, M. Vélez, I. Prieto Gonzalez, A. Bercher, J. Teyssier, I. Errea, A.Y. Nikitin, J. Martín-Sánchez, A.B. Kuzmenko, P. Alonso-González, ACS Photonics 11 (2024) 3570–3577.","mla":"Taboada-Gutiérrez, Javier, et al. “Unveiling the Mechanism of Phonon-Polariton Damping in Α‑MoO3.” <i>ACS Photonics</i>, vol. 11, no. 9, American Chemical Society, 2024, pp. 3570–77, doi:<a href=\"https://doi.org/10.1021/acsphotonics.4c00485\">10.1021/acsphotonics.4c00485</a>.","ista":"Taboada-Gutiérrez J, Zhou Y, Tresguerres-Mata AIF, Lanza C, Martínez-Suárez A, Álvarez-Pérez G, Duan J, Martín JI, Vélez M, Prieto Gonzalez I, Bercher A, Teyssier J, Errea I, Nikitin AY, Martín-Sánchez J, Kuzmenko AB, Alonso-González P. 2024. Unveiling the mechanism of phonon-polariton damping in α‑MoO3. ACS Photonics. 11(9), 3570–3577.","apa":"Taboada-Gutiérrez, J., Zhou, Y., Tresguerres-Mata, A. I. F., Lanza, C., Martínez-Suárez, A., Álvarez-Pérez, G., … Alonso-González, P. (2024). Unveiling the mechanism of phonon-polariton damping in α‑MoO3. <i>ACS Photonics</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsphotonics.4c00485\">https://doi.org/10.1021/acsphotonics.4c00485</a>"},"day":"01","oa_version":"Published Version","external_id":{"isi":["001298164600001"],"arxiv":["2408.09811"],"pmid":["39310295"]},"das_tickbox":"0","volume":11,"ddc":["530"],"fulldoi":"https://doi.org/10.1021/acsphotonics.4c00485","intvolume":"        11","acknowledgement":"Funding Sources ─ A.I.F.T.-M. and G.Á.-P. acknowledge support through the Severo Ochoa program from the Government of the Principality of Asturias (references PA-21-PF-BP20-117 and PA20-PF-BP19-053, respectively). A.B.K. and J.T.-G. acknowledge support from the Swiss National Science Foundation (grant # 200020_201096). J.M.-S. acknowledges financial support from the Ramón y Cajal Program of the Government of Spain and FSE (RYC2018-026196-I), the Spanish Ministry of Science and Innovation (State Plan for Scientific and Technical Research and Innovation grant number PID2019-110308GA-I00/AEI/10.13039/501100011033) and project PCI2022-132953 funded by MCIN/AEI/10.13039/501100011033 and the EU “NextGenerationEU”/PRTR”. P.A.-G. acknowledges support from the European Research Council under starting grant no. 715496, 2DNANOPTICA and the Spanish Ministry of Science and Innovation (State Plan for Scientific and Technical Research and Innovation grant number PID2019-111156GB-I00). A.Y.N. acknowledges the Spanish Ministry of Science and Innovation (grant PID2020-115221GB-C42) and the Basque Department of Education (grant PIBA-2023-1-0007). M.V. and J.I.M. acknowledge support by Spanish MCIN/AEI/10.13039/501100011033/FEDER, UE under grant PID2022-136784NB and by Asturias FICYT under grant AYUD/2021/51185 with the support of FEDER funds. I.E. acknowledges funding from the Spanish Ministry of Science and Innovation (Grant No. PID2022-142861NA-I00) and the Department of Education, Universities, and Research of the Eusko Jaurlaritza and the University of the Basque Country UPV/EHU (Grant No. IT1527-22). J. Duan acknowledges the support from the Beijing Natural Science Foundation (Grant No. Z240005), and National Natural Science Foundation of China.","language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Phonon polaritons (PhPs), light coupled to lattice vibrations, in the highly anisotropic polar layered material molybdenum trioxide (α-MoO3) are currently the focus of intense research efforts due to their extreme subwavelength field confinement, directional propagation, and unprecedented low losses. Nevertheless, prior research has primarily concentrated on exploiting the squeezing and steering capabilities of α-MoO3 PhPs, without inquiring much into the dominant microscopic mechanism that determines their long lifetimes, which is key for their implementation in nanophotonic applications. This study delves into the fundamental processes that govern PhP damping in α-MoO3 by combining ab initio calculations with scattering-type scanning near-field optical microscopy (s-SNOM) and Fourier transform infrared (FTIR) spectroscopy measurements across a broad temperature range (8–300 K). The remarkable agreement between our theoretical predictions and experimental observations allows us to identify third-order anharmonic phonon–phonon scattering as the main damping mechanism of α-MoO3 PhPs. These findings shed light on the fundamental limits of low-loss PhPs, which is a crucial factor for assessing their implementation into nanophotonic devices."}],"isi":1,"doi":"10.1021/acsphotonics.4c00485","publication_identifier":{"eissn":["2330-4022"]},"OA_type":"hybrid","department":[{"_id":"NanoFab"}],"type":"journal_article","year":"2024","scopus_import":"1","pmid":1,"license":"https://creativecommons.org/licenses/by/4.0/","OA_place":"publisher","quality_controlled":"1","oa":1,"file_date_updated":"2025-01-09T14:01:06Z","page":"3570-3577","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","publisher":"American Chemical Society","article_processing_charge":"No","researchdata_availability":"no","date_updated":"2026-10-21T08:08:01Z","month":"09","date_created":"2024-09-01T22:01:09Z","arxiv":1,"title":"Unveiling the mechanism of phonon-polariton damping in α‑MoO3","article_type":"original","_id":"17479","supplementarymaterial":"yes","publication":"ACS Photonics","file":[{"date_updated":"2025-01-09T14:01:06Z","success":1,"file_id":"18819","date_created":"2025-01-09T14:01:06Z","file_size":2664512,"content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"bd7e6a138c406e93eaf0a6268fc42bfe","creator":"dernst","file_name":"2024_ACSPhotonics_TaboadaGutierrez_.pdf"}],"date_published":"2024-09-01T00:00:00Z","author":[{"full_name":"Taboada-Gutiérrez, Javier","first_name":"Javier","last_name":"Taboada-Gutiérrez"},{"full_name":"Zhou, Yixi","last_name":"Zhou","first_name":"Yixi"},{"full_name":"Tresguerres-Mata, Ana I.F.","last_name":"Tresguerres-Mata","first_name":"Ana I.F."},{"first_name":"Christian","last_name":"Lanza","full_name":"Lanza, Christian"},{"full_name":"Martínez-Suárez, Abel","last_name":"Martínez-Suárez","first_name":"Abel"},{"last_name":"Álvarez-Pérez","first_name":"Gonzalo","full_name":"Álvarez-Pérez, Gonzalo"},{"full_name":"Duan, Jiahua","first_name":"Jiahua","last_name":"Duan"},{"last_name":"Martín","first_name":"José Ignacio","full_name":"Martín, José Ignacio"},{"full_name":"Vélez, María","last_name":"Vélez","first_name":"María"},{"last_name":"Prieto Gonzalez","orcid":"0000-0002-7370-5357","first_name":"Ivan","id":"2A307FE2-F248-11E8-B48F-1D18A9856A87","full_name":"Prieto Gonzalez, Ivan"},{"last_name":"Bercher","first_name":"Adrien","full_name":"Bercher, Adrien"},{"full_name":"Teyssier, Jérémie","last_name":"Teyssier","first_name":"Jérémie"},{"full_name":"Errea, Ion","last_name":"Errea","first_name":"Ion"},{"full_name":"Nikitin, Alexey Y.","last_name":"Nikitin","first_name":"Alexey Y."},{"last_name":"Martín-Sánchez","first_name":"Javier","full_name":"Martín-Sánchez, Javier"},{"first_name":"Alexey B.","last_name":"Kuzmenko","full_name":"Kuzmenko, Alexey B."},{"first_name":"Pablo","last_name":"Alonso-González","full_name":"Alonso-González, Pablo"}]},{"citation":{"mla":"Hanauer, Kathrin, et al. “Expander Hierarchies for Normalized Cuts on Graphs.” <i>Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining</i>, ACM, 2024, pp. 1016–27, doi:<a href=\"https://doi.org/10.1145/3637528.3671978\">10.1145/3637528.3671978</a>.","ieee":"K. Hanauer, M. Henzinger, R. Münk, H. Räcke, and M. Vötsch, “Expander hierarchies for normalized cuts on graphs,” in <i>Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining</i>, Barcelona, Spain, 2024, pp. 1016–1027.","chicago":"Hanauer, Kathrin, Monika Henzinger, Robin Münk, Harald Räcke, and Maximilian Vötsch. “Expander Hierarchies for Normalized Cuts on Graphs.” In <i>Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining</i>, 1016–27. ACM, 2024. <a href=\"https://doi.org/10.1145/3637528.3671978\">https://doi.org/10.1145/3637528.3671978</a>.","ama":"Hanauer K, Henzinger M, Münk R, Räcke H, Vötsch M. Expander hierarchies for normalized cuts on graphs. In: <i>Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining</i>. ACM; 2024:1016-1027. doi:<a href=\"https://doi.org/10.1145/3637528.3671978\">10.1145/3637528.3671978</a>","short":"K. Hanauer, M. Henzinger, R. Münk, H. Räcke, M. Vötsch, in:, Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining, ACM, 2024, pp. 1016–1027.","apa":"Hanauer, K., Henzinger, M., Münk, R., Räcke, H., &#38; Vötsch, M. (2024). Expander hierarchies for normalized cuts on graphs. In <i>Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining</i> (pp. 1016–1027). Barcelona, Spain: ACM. <a href=\"https://doi.org/10.1145/3637528.3671978\">https://doi.org/10.1145/3637528.3671978</a>","ista":"Hanauer K, Henzinger M, Münk R, Räcke H, Vötsch M. 2024. Expander hierarchies for normalized cuts on graphs. Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining. KDD: Knowledge Discovery and Data Mining, 1016–1027."},"day":"01","oa_version":"Published Version","external_id":{"isi":["001324524201013"]},"status":"public","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"language":[{"iso":"eng"}],"abstract":[{"text":"Expander decompositions of graphs have significantly advanced the understanding of many classical graph problems and led to numerous fundamental theoretical results. However, their adoption in practice has been hindered due to their inherent intricacies and large hidden factors in their asymptotic running times. Here, we introduce the first practically efficient algorithm for computing expander decompositions and their hierarchies and demonstrate its effectiveness and utility by incorporating it as the core component in a novel solver for the normalized cut graph clustering objective.\r\nOur extensive experiments on a variety of large graphs show that our expander-based algorithm outperforms state-of-the-art solvers for normalized cut with respect to solution quality by a large margin on a variety of graph classes such as citation, e-mail, and social networks or web graphs while remaining competitive in running time.","lang":"eng"}],"isi":1,"doi":"10.1145/3637528.3671978","publication_identifier":{"isbn":["9798400704901"]},"das_tickbox":"0","ddc":["000"],"fulldoi":"https://doi.org/10.1145/3637528.3671978","acknowledgement":"Monika Henzinger: This project has received funding from the European Research\r\nCouncil (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 101019564) and the Austrian Science Fund (FWF) grant DOI 10.55776/Z422, grant DOI 10.55776/I5982, and grant DOI 10.55776/P33775 with additional funding from the netidee SCIENCE Stiftung, 2020–2024.\r\nHarald Räcke, Robin Münk: This project has received funding from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – 498605858 and 470029389.","OA_place":"publisher","oa":1,"quality_controlled":"1","file_date_updated":"2025-01-27T13:25:23Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"1016-1027","publication_status":"published","publisher":"ACM","project":[{"grant_number":"101019564","_id":"bd9ca328-d553-11ed-ba76-dc4f890cfe62","call_identifier":"H2020","name":"The design and evaluation of modern fully dynamic data structures"},{"_id":"34def286-11ca-11ed-8bc3-da5948e1613c","grant_number":"Z00422","name":"Efficient algorithms"},{"_id":"bda196b2-d553-11ed-ba76-8e8ee6c21103","grant_number":"I05982","name":"Static and Dynamic Hierarchical Graph Decompositions"}],"OA_type":"hybrid","department":[{"_id":"MoHe"}],"year":"2024","type":"conference","scopus_import":"1","conference":{"start_date":"2024-08-05","name":"KDD: Knowledge Discovery and Data Mining","location":"Barcelona, Spain","end_date":"2024-08-29"},"ec_funded":1,"_id":"18906","supplementarymaterial":"yes","file":[{"file_size":1450331,"date_created":"2025-01-27T13:25:23Z","success":1,"file_id":"18907","date_updated":"2025-01-27T13:25:23Z","checksum":"1265d5cf6aa5f94157631651723c4a2b","relation":"main_file","file_name":"2024_ACMKDD_Hanauer.pdf","creator":"dernst","content_type":"application/pdf","access_level":"open_access"}],"publication":"Proceedings of the 30th ACM SIGKDD Conference on Knowledge Discovery and Data Mining","date_published":"2024-09-01T00:00:00Z","author":[{"last_name":"Hanauer","first_name":"Kathrin","full_name":"Hanauer, Kathrin"},{"first_name":"Monika H","orcid":"0000-0002-5008-6530","last_name":"Henzinger","full_name":"Henzinger, Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"},{"first_name":"Robin","last_name":"Münk","full_name":"Münk, Robin"},{"last_name":"Räcke","first_name":"Harald","full_name":"Räcke, Harald"},{"full_name":"Vötsch, Maximilian","last_name":"Vötsch","first_name":"Maximilian"}],"article_processing_charge":"Yes (in subscription journal)","researchdata_availability":"no","month":"09","date_updated":"2026-10-21T08:06:58Z","date_created":"2025-01-27T13:20:26Z","title":"Expander hierarchies for normalized cuts on graphs"},{"date_published":"2024-09-01T00:00:00Z","author":[{"last_name":"Braun","first_name":"Pirmin","full_name":"Braun, Pirmin"},{"id":"0a01c7b2-b823-11ed-9928-cc3f874f9ffd","full_name":"Hahn, Niklas","last_name":"Hahn","first_name":"Niklas"},{"full_name":"Hoefer, Martin","last_name":"Hoefer","first_name":"Martin"},{"first_name":"Conrad","last_name":"Schecker","full_name":"Schecker, Conrad"}],"publication":"Artificial Intelligence","file":[{"file_size":772226,"date_created":"2025-01-09T10:45:24Z","success":1,"file_id":"18806","date_updated":"2025-01-09T10:45:24Z","checksum":"f02a56bc7ea88f41fcc68968e4ceddf3","relation":"main_file","file_name":"2024_ArtificialIntelligence_Braun.pdf","creator":"dernst","content_type":"application/pdf","access_level":"open_access"}],"supplementarymaterial":"no","_id":"17188","title":"Delegated online search","article_type":"original","date_created":"2024-06-30T22:01:05Z","arxiv":1,"month":"09","date_updated":"2026-10-21T08:06:15Z","researchdata_availability":"not applicable","article_processing_charge":"Yes (in subscription journal)","publication_status":"published","publisher":"Elsevier","dataavailabilitystatement":"No data was used for the research described in the article.\r\n","file_date_updated":"2025-01-09T10:45:24Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","OA_place":"publisher","quality_controlled":"1","article_number":"104171","oa":1,"corr_author":"1","type":"journal_article","year":"2024","scopus_import":"1","department":[{"_id":"MoHe"}],"OA_type":"hybrid","publication_identifier":{"issn":["0004-3702"]},"doi":"10.1016/j.artint.2024.104171","abstract":[{"lang":"eng","text":"In a delegation problem, a principal P with commitment power tries to pick one out of 𝑛 options.\r\nEach option is drawn independently from a known distribution. Instead of inspecting the options\r\nherself, P delegates the information acquisition to a rational and self-interested agent A. After\r\ninspection, A proposes one of the options, and P can accept or reject.\r\nDelegation is a classic setting in economic information design with many prominent applications,\r\nbut the computational problems are only poorly understood. In this paper, we study a natural\r\nonline variant of delegation, in which the agent searches through the options in an online fashion.\r\nFor each option, he has to irrevocably decide if he wants to propose the current option or discard\r\nit, before seeing information on the next option(s). How can we design algorithms for P that\r\napproximate the utility of her best option in hindsight?\r\nWe show that in general P can obtain a Θ(1∕𝑛)-approximation and extend this result to ratios\r\nof Θ(𝑘∕𝑛) in case (1) A has a lookahead of 𝑘 rounds, or (2) A can propose up to 𝑘 different\r\noptions. We provide fine-grained bounds independent of 𝑛 based on three parameters. If the ratio\r\nof maximum and minimum utility for A is bounded by a factor 𝛼, we obtain an Ω(loglog 𝛼∕ log 𝛼)-\r\napproximation algorithm, and we show that this is best possible. Additionally, if P cannot\r\ndistinguish options with the same value for herself, we show that ratios polynomial in 1∕𝛼 cannot\r\nbe avoided. If there are at most 𝛽 different utility values for A, we show a Θ(1∕𝛽)-approximation.\r\nIf the utilities of P and A for each option are related by a factor 𝛾, we obtain an Ω(1∕ log 𝛾)-\r\napproximation, where 𝑂(log log 𝛾∕ log 𝛾) is best possible."}],"isi":1,"language":[{"iso":"eng"}],"acknowledgement":"Hahn gratefully acknowledges the support of GIF grant I-1419-118.4/2017. Hoefer gratefully acknowledges the support of GIF grant I-1419-118.4/2017, DFG Research Unit ADYN (project number 411362735), and DFG grant Ho 3831/9-1 (project number 514505843).","intvolume":"       334","fulldoi":"https://doi.org/10.1016/j.artint.2024.104171","ddc":["000"],"volume":334,"das_tickbox":"1","oa_version":"Published Version","external_id":{"arxiv":["2203.01084"],"isi":["001260448100001"]},"day":"01","citation":{"mla":"Braun, Pirmin, et al. “Delegated Online Search.” <i>Artificial Intelligence</i>, vol. 334, 104171, Elsevier, 2024, doi:<a href=\"https://doi.org/10.1016/j.artint.2024.104171\">10.1016/j.artint.2024.104171</a>.","ieee":"P. Braun, N. Hahn, M. Hoefer, and C. Schecker, “Delegated online search,” <i>Artificial Intelligence</i>, vol. 334. Elsevier, 2024.","chicago":"Braun, Pirmin, Niklas Hahn, Martin Hoefer, and Conrad Schecker. “Delegated Online Search.” <i>Artificial Intelligence</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.artint.2024.104171\">https://doi.org/10.1016/j.artint.2024.104171</a>.","ama":"Braun P, Hahn N, Hoefer M, Schecker C. Delegated online search. <i>Artificial Intelligence</i>. 2024;334. doi:<a href=\"https://doi.org/10.1016/j.artint.2024.104171\">10.1016/j.artint.2024.104171</a>","short":"P. Braun, N. Hahn, M. Hoefer, C. Schecker, Artificial Intelligence 334 (2024).","apa":"Braun, P., Hahn, N., Hoefer, M., &#38; Schecker, C. (2024). Delegated online search. <i>Artificial Intelligence</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.artint.2024.104171\">https://doi.org/10.1016/j.artint.2024.104171</a>","ista":"Braun P, Hahn N, Hoefer M, Schecker C. 2024. Delegated online search. Artificial Intelligence. 334, 104171."},"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","status":"public"},{"_id":"17238","supplementarymaterial":"yes","file":[{"success":1,"file_id":"17241","date_updated":"2024-07-15T09:45:25Z","date_created":"2024-07-15T09:45:25Z","file_size":1194263,"content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"94e6b68bddf6cadcec29c7f41647359f","creator":"dernst","file_name":"2024_JourEvolutionaryBiology_Barton.pdf"}],"publication":"Journal of Evolutionary Biology","date_published":"2024-06-01T00:00:00Z","author":[{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton"}],"article_processing_charge":"Yes (via OA deal)","researchdata_availability":"yes (supplementary data)","date_updated":"2026-10-21T08:11:09Z","month":"06","date_created":"2024-07-14T22:01:12Z","title":"Limits to species' range: The tension between local and global adaptation","article_type":"review","oa":1,"quality_controlled":"1","dataavailabilitystatement":"All code used to generate the figures is in the accompanying Mathematica notebook.","file_date_updated":"2024-07-15T09:45:25Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"605-615","publication_status":"published","publisher":"Oxford University Press","project":[{"name":"Understanding the evolution of continuous genomes","_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00","grant_number":"101055327"}],"department":[{"_id":"NiBa"}],"corr_author":"1","type":"journal_article","year":"2024","scopus_import":"1","pmid":1,"language":[{"iso":"eng"}],"abstract":[{"text":"We know that heritable variation is abundant, and that selection causes all but the smallest populations to rapidly shift beyond their original trait distribution. So then, what limits the range of a species? There are physical constraints and also population genetic limits to the effectiveness of selection, ultimately set by population size. Global adaptation, where the same genotype is favoured over the whole range, is most efficient when based on a multitude of weakly selected alleles and is effective even when local demes are small, provided that there is some gene flow. In contrast, local adaptation is sensitive to gene flow and may require alleles with substantial effect. How can populations combine the advantages of large effective size with the ability to specialise into local niches? To what extent does reproductive isolation help resolve this tension? I address these questions using eco-evolutionary models of polygenic adaptation, contrasting discrete demes with continuousspace.","lang":"eng"}],"isi":1,"doi":"10.1093/jeb/voae052","publication_identifier":{"issn":["1010-061X"],"eissn":["1420-9101"]},"das_tickbox":"1","volume":37,"ddc":["570"],"fulldoi":"https://doi.org/10.1093/jeb/voae052","acknowledgement":"This work was supported by a grant from the ERC, 101055327, “HaplotypeStructure”. I thank Himani Sachdeva, Michal Hledik, Jitka Polechova, and the reviewers for their helpful comments.","intvolume":"        37","issue":"6","citation":{"ista":"Barton NH. 2024. Limits to species’ range: The tension between local and global adaptation. Journal of Evolutionary Biology. 37(6), 605–615.","apa":"Barton, N. H. (2024). Limits to species’ range: The tension between local and global adaptation. <i>Journal of Evolutionary Biology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jeb/voae052\">https://doi.org/10.1093/jeb/voae052</a>","short":"N.H. Barton, Journal of Evolutionary Biology 37 (2024) 605–615.","ama":"Barton NH. Limits to species’ range: The tension between local and global adaptation. <i>Journal of Evolutionary Biology</i>. 2024;37(6):605-615. doi:<a href=\"https://doi.org/10.1093/jeb/voae052\">10.1093/jeb/voae052</a>","chicago":"Barton, Nicholas H. “Limits to Species’ Range: The Tension between Local and Global Adaptation.” <i>Journal of Evolutionary Biology</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/jeb/voae052\">https://doi.org/10.1093/jeb/voae052</a>.","ieee":"N. H. Barton, “Limits to species’ range: The tension between local and global adaptation,” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6. Oxford University Press, pp. 605–615, 2024.","mla":"Barton, Nicholas H. “Limits to Species’ Range: The Tension between Local and Global Adaptation.” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6, Oxford University Press, 2024, pp. 605–15, doi:<a href=\"https://doi.org/10.1093/jeb/voae052\">10.1093/jeb/voae052</a>."},"day":"01","oa_version":"Published Version","external_id":{"pmid":["38683160"],"isi":["001225323900001"]},"has_accepted_license":"1","status":"public","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"publisher":"Oxford University Press","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"677-692","dataavailabilitystatement":"Individual high-quality reads (paired-end reads) generated in the present study (fq.gz files) and the filtered vcf file can be accessed via the Dryad repository at https://doi.org/10.5061/dryad.tb2rbp064. Additionally, the scaffolds assembly of the Laminaria digitata genome, utilized for read mapping and produced by Gernot Glöckner, is also available in the same repository. Furthermore, the custom R script developed for identifying temporal outlier SNPs, along with the FST datasets comparing observed and simulated FST between time points, can be found on GitHub at https://doi.org/10.5281/zenodo.10946282.","oa":1,"quality_controlled":"1","pmid":1,"year":"2024","scopus_import":"1","type":"journal_article","department":[{"_id":"NiBa"}],"author":[{"full_name":"Reynes, Lauric","first_name":"Lauric","last_name":"Reynes"},{"id":"1676e173-8143-11ed-8927-fe165216a93f","full_name":"Fouqueau, Louise","last_name":"Fouqueau","orcid":"0000-0003-0371-9339","first_name":"Louise"},{"full_name":"Aurelle, Didier","last_name":"Aurelle","first_name":"Didier"},{"first_name":"Stephane","last_name":"Mauger","full_name":"Mauger, Stephane"},{"full_name":"Destombe, Christophe","last_name":"Destombe","first_name":"Christophe"},{"full_name":"Valero, Myriam","first_name":"Myriam","last_name":"Valero"}],"date_published":"2024-06-01T00:00:00Z","publication":"Journal of Evolutionary Biology","supplementarymaterial":"yes","_id":"17237","article_type":"original","title":"Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations","arxiv":1,"date_created":"2024-07-14T22:01:12Z","date_updated":"2026-10-21T08:10:14Z","month":"06","researchdata_availability":"yes","article_processing_charge":"No","external_id":{"arxiv":["2404.14003"],"pmid":["38629140"]},"oa_version":"Preprint","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2404.14003"}],"day":"01","citation":{"ista":"Reynes L, Fouqueau L, Aurelle D, Mauger S, Destombe C, Valero M. 2024. Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations. Journal of Evolutionary Biology. 37(6), 677–692.","apa":"Reynes, L., Fouqueau, L., Aurelle, D., Mauger, S., Destombe, C., &#38; Valero, M. (2024). Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations. <i>Journal of Evolutionary Biology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jeb/voae048\">https://doi.org/10.1093/jeb/voae048</a>","ama":"Reynes L, Fouqueau L, Aurelle D, Mauger S, Destombe C, Valero M. Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations. <i>Journal of Evolutionary Biology</i>. 2024;37(6):677-692. doi:<a href=\"https://doi.org/10.1093/jeb/voae048\">10.1093/jeb/voae048</a>","chicago":"Reynes, Lauric, Louise Fouqueau, Didier Aurelle, Stephane Mauger, Christophe Destombe, and Myriam Valero. “Temporal Genomics Help in Deciphering Neutral and Adaptive Patterns in the Contemporary Evolution of Kelp Populations.” <i>Journal of Evolutionary Biology</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/jeb/voae048\">https://doi.org/10.1093/jeb/voae048</a>.","short":"L. Reynes, L. Fouqueau, D. Aurelle, S. Mauger, C. Destombe, M. Valero, Journal of Evolutionary Biology 37 (2024) 677–692.","ieee":"L. Reynes, L. Fouqueau, D. Aurelle, S. Mauger, C. Destombe, and M. Valero, “Temporal genomics help in deciphering neutral and adaptive patterns in the contemporary evolution of kelp populations,” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6. Oxford University Press, pp. 677–692, 2024.","mla":"Reynes, Lauric, et al. “Temporal Genomics Help in Deciphering Neutral and Adaptive Patterns in the Contemporary Evolution of Kelp Populations.” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6, Oxford University Press, 2024, pp. 677–92, doi:<a href=\"https://doi.org/10.1093/jeb/voae048\">10.1093/jeb/voae048</a>."},"issue":"6","status":"public","publication_identifier":{"issn":["1010-061X"],"eissn":["1420-9101"]},"doi":"10.1093/jeb/voae048","abstract":[{"text":"The impact of climate change on populations will be contingent upon their contemporary adaptive evolution. In this study, we investigated the contemporary evolution of 4 populations of the cold-water kelp Laminaria digitata by analyzing their spatial and temporal genomic variations using ddRAD-sequencing. These populations were sampled from the center to the southern margin of its north-eastern Atlantic distribution at 2 time points, spanning at least 2 generations. Through genome scans for local adaptation at a single time point, we identified candidate loci that showed clinal variation correlated with changes in sea surface temperature (SST) along latitudinal gradients. This finding suggests that SST may drive the adaptive response of these kelp populations, although factors such as species’ demographic history should also be considered. Additionally, we performed a simulation approach to distinguish the effect of selection from genetic drift in allele frequency changes over time. This enabled the detection of loci in the southernmost population that exhibited temporal differentiation beyond what would be expected from genetic drift alone: these are candidate loci which could have evolved under selection over time. In contrast, we did not detect any outlier locus based on temporal differentiation in the population from the North Sea, which also displayed low and decreasing levels of genetic diversity. The diverse evolutionary scenarios observed among populations can be attributed to variations in the prevalence of selection relative to genetic drift across different environments. Therefore, our study highlights the potential of temporal genomics to offer valuable insights into the contemporary evolution of marine foundation species facing climate change.","lang":"eng"}],"language":[{"iso":"eng"}],"intvolume":"        37","acknowledgement":"This work was funded by the EU project MARFOR Biodiversa/004/2015. L.F. was additionally funded by the Region Bretagne (ARED 2017 REEALG) and the NOMIS Foundation. The project leading to this publication has received funding from the EC2CO (CNRS) fund and from the European FEDER Fund under project 1166-39417.\r\nThis work is especially dedicated to the memory of Gernot Glöckner who contributed to the sequencing of Laminaria digitata genome and passed away in very recent time. The authors thank the ABiMS platform of the Roscoff biological station (http://abims.sb-roscoff.fr) for providing the HPC resources that contributed to the search results reported in this document. We also acknowledge the staff of the “Cluster de calcul intensif HPC” Platform of the OSU Institut Pythéas (Aix-Marseille Université, INSU-CNRS) for providing the computing facilities.","fulldoi":"https://doi.org/10.1093/jeb/voae048","related_material":{"record":[{"id":"22867","relation":"research_data","status":"public"}]},"volume":37,"das_tickbox":"1"},{"status":"public","day":"01","oa_version":"None","external_id":{"isi":["001419526400005"]},"citation":{"mla":"Georgiadis, Loukas, et al. “Computing the 3-Edge-Connected Components of Directed Graphs in Linear Time.” <i>65th Annual Symposium on Foundations of Computer Science</i>, IEEE, 2024, pp. 62–85, doi:<a href=\"https://doi.org/10.1109/focs61266.2024.00015\">10.1109/focs61266.2024.00015</a>.","ieee":"L. Georgiadis, G. F. Italiano, and E. Kosinas, “Computing the 3-edge-connected components of directed graphs in linear time,” in <i>65th Annual Symposium on Foundations of Computer Science</i>, Chicago, IL, United States, 2024, pp. 62–85.","short":"L. Georgiadis, G.F. Italiano, E. Kosinas, in:, 65th Annual Symposium on Foundations of Computer Science, IEEE, 2024, pp. 62–85.","chicago":"Georgiadis, Loukas, Giuseppe F. Italiano, and Evangelos Kosinas. “Computing the 3-Edge-Connected Components of Directed Graphs in Linear Time.” In <i>65th Annual Symposium on Foundations of Computer Science</i>, 62–85. IEEE, 2024. <a href=\"https://doi.org/10.1109/focs61266.2024.00015\">https://doi.org/10.1109/focs61266.2024.00015</a>.","ama":"Georgiadis L, Italiano GF, Kosinas E. Computing the 3-edge-connected components of directed graphs in linear time. In: <i>65th Annual Symposium on Foundations of Computer Science</i>. IEEE; 2024:62-85. doi:<a href=\"https://doi.org/10.1109/focs61266.2024.00015\">10.1109/focs61266.2024.00015</a>","apa":"Georgiadis, L., Italiano, G. F., &#38; Kosinas, E. (2024). Computing the 3-edge-connected components of directed graphs in linear time. In <i>65th Annual Symposium on Foundations of Computer Science</i> (pp. 62–85). Chicago, IL, United States: IEEE. <a href=\"https://doi.org/10.1109/focs61266.2024.00015\">https://doi.org/10.1109/focs61266.2024.00015</a>","ista":"Georgiadis L, Italiano GF, Kosinas E. 2024. Computing the 3-edge-connected components of directed graphs in linear time. 65th Annual Symposium on Foundations of Computer Science. FOCS: Foundations of Computer Science, 62–85."},"fulldoi":"https://doi.org/10.1109/focs61266.2024.00015","acknowledgement":"Giuseppe F. Italiano was partially supported by the Italian Ministry of\r\nUniversity and Reseach under PRIN Project n. 2022TS4Y3N - EXPAND: scalable algorithms for EXPloratory Analyses of heterogeneous and dynamic Networked Data.\r\n","das_tickbox":"0","doi":"10.1109/focs61266.2024.00015","publication_identifier":{"isbn":["9798331516741"]},"language":[{"iso":"eng"}],"abstract":[{"text":"Let G be a directed graph with m edges and n vertices. We present a deterministic linear-time algorithm for computing the 3-edge-connected components of G. This is a significant improvement over the previous best bound by Georgiadis et al. [SODA 2023], which is Õ(m√{m}) and randomized. Our result is based on a novel characterization of 2-edge cuts in directed graphs and on a new technique that exploits the concept of divergent spanning trees and 2-connectivity-light graphs, and requires a careful modification of the minset-poset technique of Gabow [TALG 2016]. As a side result, our new technique yields also an oracle for providing in constant time a minimum edge-cut for any two vertices that are not 3-edge-connected. The oracle uses space O(n) and can be built in O(mlog n) time: given two query vertices, it determines in constant time whether they are 3-edge-connected, or provides a k-edge cut, with k≤ 2, that separates them.","lang":"eng"}],"isi":1,"OA_type":"closed access","department":[{"_id":"MoHe"}],"corr_author":"1","year":"2024","scopus_import":"1","type":"conference","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"62-85","publication_status":"published","publisher":"IEEE","quality_controlled":"1","date_created":"2025-01-27T14:50:23Z","title":"Computing the 3-edge-connected components of directed graphs in linear time","article_processing_charge":"No","date_updated":"2026-10-21T08:07:18Z","month":"10","researchdata_availability":"no","publication":"65th Annual Symposium on Foundations of Computer Science","date_published":"2024-10-01T00:00:00Z","author":[{"full_name":"Georgiadis, Loukas","last_name":"Georgiadis","first_name":"Loukas"},{"last_name":"Italiano","first_name":"Giuseppe F.","full_name":"Italiano, Giuseppe F."},{"full_name":"Kosinas, Evangelos","id":"4c7f9625-dbbc-11ee-9d86-bdcc2db5a949","first_name":"Evangelos","last_name":"Kosinas"}],"conference":{"location":"Chicago, IL, United States","name":"FOCS: Foundations of Computer Science","start_date":"2024-10-27","end_date":"2024-10-30"},"_id":"18922","supplementarymaterial":"no"},{"citation":{"mla":"Fouqueau, Louise, and Jitka Polechova. “Eco-Evolutionary Dynamics in Changing Environments: Integrating Theory with Data.” <i>Journal of Evolutionary Biology</i>, vol. 37, no. 6, Oxford University Press, 2024, pp. 579–87, doi:<a href=\"https://doi.org/10.1093/jeb/voae067\">10.1093/jeb/voae067</a>.","ama":"Fouqueau L, Polechova J. Eco-evolutionary dynamics in changing environments: Integrating theory with data. <i>Journal of evolutionary biology</i>. 2024;37(6):579-587. doi:<a href=\"https://doi.org/10.1093/jeb/voae067\">10.1093/jeb/voae067</a>","short":"L. Fouqueau, J. Polechova, Journal of Evolutionary Biology 37 (2024) 579–587.","chicago":"Fouqueau, Louise, and Jitka Polechova. “Eco-Evolutionary Dynamics in Changing Environments: Integrating Theory with Data.” <i>Journal of Evolutionary Biology</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/jeb/voae067\">https://doi.org/10.1093/jeb/voae067</a>.","ieee":"L. Fouqueau and J. Polechova, “Eco-evolutionary dynamics in changing environments: Integrating theory with data,” <i>Journal of evolutionary biology</i>, vol. 37, no. 6. Oxford University Press, pp. 579–587, 2024.","apa":"Fouqueau, L., &#38; Polechova, J. (2024). Eco-evolutionary dynamics in changing environments: Integrating theory with data. <i>Journal of Evolutionary Biology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/jeb/voae067\">https://doi.org/10.1093/jeb/voae067</a>","ista":"Fouqueau L, Polechova J. 2024. Eco-evolutionary dynamics in changing environments: Integrating theory with data. Journal of evolutionary biology. 37(6), 579–587."},"issue":"6","external_id":{"pmid":["38941551"],"isi":["001258359900001"]},"oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1093/jeb/voae067"}],"day":"28","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","isi":1,"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1420-9101"]},"doi":"10.1093/jeb/voae067","ddc":["570"],"das_tickbox":"0","volume":37,"intvolume":"        37","acknowledgement":"This research was funded by the Austrian Science Fund (FWF), project doi: 10.55776/P32896, Institutional Identifier: 501100002428, grant number: P32896 and L.F. acknowledges the support of the NOMIS-ISTA Fellowship Program.\r\nWe would like to thank Nick Barton, Roger Butlin, Stuart Baird, Patrik Nosil, and Jason Sexton for their insightful comments on the earlier drafts, and to John Carchrae for his valuable contribution in refining phrasing and enhancing clarity. For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission.","fulldoi":"https://doi.org/10.1093/jeb/voae067","quality_controlled":"1","oa":1,"publisher":"Oxford University Press","publication_status":"published","page":"579-587","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","scopus_import":"1","type":"journal_article","year":"2024","department":[{"_id":"NiBa"}],"project":[{"name":"Causes and consequences of population fragmentation","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8","grant_number":"P32896"},{"name":"NOMIS Fellowship Program","_id":"9B861AAC-BA93-11EA-9121-9846C619BF3A"}],"pmid":1,"supplementarymaterial":"no","_id":"17207","author":[{"id":"1676e173-8143-11ed-8927-fe165216a93f","full_name":"Fouqueau, Louise","last_name":"Fouqueau","orcid":"0000-0003-0371-9339","first_name":"Louise"},{"id":"3BBFB084-F248-11E8-B48F-1D18A9856A87","full_name":"Polechova, Jitka","last_name":"Polechova","orcid":"0000-0003-0951-3112","first_name":"Jitka"}],"date_published":"2024-06-28T00:00:00Z","publication":"Journal of evolutionary biology","date_updated":"2026-10-21T08:08:57Z","month":"06","researchdata_availability":"no","article_processing_charge":"No","article_type":"letter_note","title":"Eco-evolutionary dynamics in changing environments: Integrating theory with data","date_created":"2024-07-07T22:01:04Z"},{"project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships"},{"grant_number":"P32166","_id":"05959E1C-7A3F-11EA-A408-12923DDC885E","name":"Snapdragon Speciation"}],"department":[{"_id":"NiBa"}],"corr_author":"1","scopus_import":"1","type":"journal_article","year":"2024","file_date_updated":"2024-09-11T07:14:03Z","dataavailabilitystatement":"The datasets generated and analysed during the current study will be deposited to the ISTA Research Explorer repository upon manuscript acceptance. Voucher specimens of insects are deposited in the Museo Nacional de Ciencias Naturales, Spain.","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","publisher":"Springer Nature","quality_controlled":"1","oa":1,"article_number":"172","date_created":"2024-09-08T22:01:11Z","article_type":"original","title":"Multiscale spatial analysis of two plant–insect interactions: Effects of landscape, resource distribution, and other insects","article_processing_charge":"Yes (via OA deal)","researchdata_availability":"yes","date_updated":"2026-10-21T08:12:11Z","month":"09","file":[{"date_updated":"2024-09-11T07:14:03Z","file_id":"18054","success":1,"date_created":"2024-09-11T07:14:03Z","file_size":1494987,"access_level":"open_access","content_type":"application/pdf","file_name":"2024_LandscapeEcology_Pocull.pdf","creator":"dernst","checksum":"2e1cbc320ec1b4447a5a8562a90bcbc3","relation":"main_file"}],"publication":"Landscape Ecology","date_published":"2024-09-01T00:00:00Z","author":[{"id":"54359172-700c-11ef-a103-c1d91ceac6d6","full_name":"Pocull Belles, Guillem","last_name":"Pocull Belles","first_name":"Guillem"},{"first_name":"Carina","last_name":"Baskett","orcid":"0000-0002-7354-8574","full_name":"Baskett, Carina","id":"3B4A7CE2-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton"}],"ec_funded":1,"_id":"17888","supplementarymaterial":"yes","has_accepted_license":"1","status":"public","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"01","oa_version":"Published Version","external_id":{"isi":["001304011900001"]},"issue":"9","citation":{"apa":"Pocull Belles, G., Baskett, C., &#38; Barton, N. H. (2024). Multiscale spatial analysis of two plant–insect interactions: Effects of landscape, resource distribution, and other insects. <i>Landscape Ecology</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s10980-024-01899-9\">https://doi.org/10.1007/s10980-024-01899-9</a>","ista":"Pocull Belles G, Baskett C, Barton NH. 2024. Multiscale spatial analysis of two plant–insect interactions: Effects of landscape, resource distribution, and other insects. Landscape Ecology. 39(9), 172.","mla":"Pocull Belles, Guillem, et al. “Multiscale Spatial Analysis of Two Plant–Insect Interactions: Effects of Landscape, Resource Distribution, and Other Insects.” <i>Landscape Ecology</i>, vol. 39, no. 9, 172, Springer Nature, 2024, doi:<a href=\"https://doi.org/10.1007/s10980-024-01899-9\">10.1007/s10980-024-01899-9</a>.","chicago":"Pocull Belles, Guillem, Carina Baskett, and Nicholas H Barton. “Multiscale Spatial Analysis of Two Plant–Insect Interactions: Effects of Landscape, Resource Distribution, and Other Insects.” <i>Landscape Ecology</i>. Springer Nature, 2024. <a href=\"https://doi.org/10.1007/s10980-024-01899-9\">https://doi.org/10.1007/s10980-024-01899-9</a>.","short":"G. Pocull Belles, C. Baskett, N.H. Barton, Landscape Ecology 39 (2024).","ama":"Pocull Belles G, Baskett C, Barton NH. Multiscale spatial analysis of two plant–insect interactions: Effects of landscape, resource distribution, and other insects. <i>Landscape Ecology</i>. 2024;39(9). doi:<a href=\"https://doi.org/10.1007/s10980-024-01899-9\">10.1007/s10980-024-01899-9</a>","ieee":"G. Pocull Belles, C. Baskett, and N. H. Barton, “Multiscale spatial analysis of two plant–insect interactions: Effects of landscape, resource distribution, and other insects,” <i>Landscape Ecology</i>, vol. 39, no. 9. Springer Nature, 2024."},"fulldoi":"https://doi.org/10.1007/s10980-024-01899-9","acknowledgement":"For the beetle barcoding, we are very thankful to Brent Emerson’s laboratory at the Consejo Superior de Investigaciones Científicas (CSIC) at the Instituto de Productos Naturales y Agrobiología (IPNA) in La Laguna, Tenerife. Many thanks to numerous field assistants, especially Sandra Cuevas Gallego, Beatriz Pablo Carmona, Luís Santos Cid and Alex Fuster, for their assistance in data collection. Finally, we thank Jesús Muñoz, Virgilio Gómez-Rubio, and two anonymous reviewers for comments that greatly improved the quality of the manuscript.\r\nOpen access funding provided by Institute of Science and Technology (IST Austria). CB received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No. 754411. NB was funded by the FWF grant “Löwenmaul speciation” P 32166-B32.","intvolume":"        39","volume":39,"das_tickbox":"1","ddc":["570"],"doi":"10.1007/s10980-024-01899-9","publication_identifier":{"issn":["0921-2973"],"eissn":["1572-9761"]},"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"Context: Biotic resource exploitation is a critical determinant of species’ distributions. However, quantifying resource exploitation patterns through space and time can be difficult, complicating their incorporation in spatial ecology studies. Therefore, understanding the local drivers of spatial patterns of resource exploitation may contribute to better large-scale species distribution models.\r\nObjectives: We investigated (1) how the resource exploitation patterns of two trophic interactions (plant–insect) are explained by insect behaviour, resource aggregation, and potential insect-insect interactions. We also analyzed how (2) resource patch size and (3) resource accessibility in a heterogeneous landscape affected host exploitation patterns.\r\nMethods: We quantified nectar robbing by insects in the genus Bombus (bumblebees) and seed predation by Brachypterolus vestitus larvae (Antirrhinum beetle) on Antirrhinum majus L. (wild snapdragons) in the Pyrenees Mountains, Catalonia, Spain. We tested hypotheses about resource exploitation by integrating spatial analyses at multiple scales.\r\nResults: Both trophic interactions were aggregated, explained by the aggregation of their resource. At some scales, nectar robbing is more aggregated than the resource. Trophic interaction abundance is proportional to resource patch size, following the ideal free distribution model. Landscape features do not explain the locations exploited. Nectar robbing and seed predation occur together more often than expected.\r\nConclusions: Our findings suggest that multiple biotic and ecological spatial factors may simultaneously affect resource exploitation at a local scale. These findings should be considered when developing agricultural projects, management plans and conservation policies."}],"isi":1},{"publication_identifier":{"issn":["1477-9145"],"eissn":["0022-0949"]},"doi":"10.1242/jeb.246217","isi":1,"abstract":[{"text":"Elaborate sexual signals are thought to have evolved and be maintained to serve as honest indicators of signaller quality. One measure of quality is health, which can be affected by parasite infection. Cnemaspis mysoriensis is a diurnal gecko that is often infested with ectoparasites in the wild, and males of this species express visual (coloured gular patches) and chemical (femoral gland secretions) traits that receivers could assess during social interactions. In this paper, we tested whether ectoparasites affect individual health, and whether signal quality is an indicator of ectoparasite levels. In wild lizards, we found that ectoparasite level was negatively correlated with body condition in both sexes. Moreover, some characteristics of both visual and chemical traits in males were strongly associated with ectoparasite levels. Specifically, males with higher ectoparasite levels had yellow gular patches with lower brightness and chroma, and chemical secretions with a lower proportion of aromatic compounds. We then determined whether ectoparasite levels in males influence female behaviour. Using sequential choice trials, wherein females were provided with either the visual or the chemical signals of wild-caught males that varied in ectoparasite level, we found that only chemical secretions evoked an elevated female response towards less parasitised males. Simultaneous choice trials in which females were exposed to the chemical secretions from males that varied in parasite level further confirmed a preference for males with lower parasites loads. Overall, we find that although health (body condition) or ectoparasite load can be honestly advertised through multiple modalities, the parasite-mediated female response is exclusively driven by chemical signals.</jats:p>","lang":"eng"}],"language":[{"iso":"eng"}],"intvolume":"       227","acknowledgement":"We thank Anuradha Batabyal and Shakilur Kabir for scientific discussions, and help with sampling and colour analyses. We thank Muralidhar and the central LCMS facility of the IISc for their technical support with the GCMS.\r\nResearch funding was provided by the Department of Science and Technology Fund for Improvement of S&T Infrastructure (DST-FIST), the Department of Biotechnology-Indian Institute of Science (DBT-IISc) partnership program and a Science and Engineering Research Board (SERB) grant to M.T. (EMR/2017/002228). Open Access funding provided by Indian Institute of Science. Deposited in PMC for immediate release.","fulldoi":"https://doi.org/10.1242/jeb.246217","related_material":{"link":[{"relation":"software","url":"https://github.com/arka-pal/Cnemaspis-SexualSignaling"}],"record":[{"status":"public","relation":"research_data","id":"22868"}]},"ddc":["570"],"das_tickbox":"1","volume":227,"external_id":{"pmid":["38054353"],"isi":["001214515700016"]},"keyword":["Insect Science","Molecular Biology","Animal Science and Zoology","Aquatic Science","Physiology","Ecology","Evolution","Behavior and Systematics"],"oa_version":"Published Version","day":"10","citation":{"ieee":"A. Pal, M. Joshi, and M. Thaker, “Too much information? Males convey parasite levels using more signal modalities than females utilise,” <i>Journal of Experimental Biology</i>, vol. 227, no. 1. The Company of Biologists, 2024.","chicago":"Pal, Arka, Mihir Joshi, and Maria Thaker. “Too Much Information? Males Convey Parasite Levels Using More Signal Modalities than Females Utilise.” <i>Journal of Experimental Biology</i>. The Company of Biologists, 2024. <a href=\"https://doi.org/10.1242/jeb.246217\">https://doi.org/10.1242/jeb.246217</a>.","ama":"Pal A, Joshi M, Thaker M. Too much information? Males convey parasite levels using more signal modalities than females utilise. <i>Journal of Experimental Biology</i>. 2024;227(1). doi:<a href=\"https://doi.org/10.1242/jeb.246217\">10.1242/jeb.246217</a>","short":"A. Pal, M. Joshi, M. Thaker, Journal of Experimental Biology 227 (2024).","mla":"Pal, Arka, et al. “Too Much Information? Males Convey Parasite Levels Using More Signal Modalities than Females Utilise.” <i>Journal of Experimental Biology</i>, vol. 227, no. 1, jeb246217, The Company of Biologists, 2024, doi:<a href=\"https://doi.org/10.1242/jeb.246217\">10.1242/jeb.246217</a>.","ista":"Pal A, Joshi M, Thaker M. 2024. Too much information? Males convey parasite levels using more signal modalities than females utilise. Journal of Experimental Biology. 227(1), jeb246217.","apa":"Pal, A., Joshi, M., &#38; Thaker, M. (2024). Too much information? Males convey parasite levels using more signal modalities than females utilise. <i>Journal of Experimental Biology</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/jeb.246217\">https://doi.org/10.1242/jeb.246217</a>"},"issue":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1","author":[{"id":"6AAB2240-CA9A-11E9-9C1A-D9D1E5697425","full_name":"Pal, Arka","orcid":"0000-0002-4530-8469","last_name":"Pal","first_name":"Arka"},{"full_name":"Joshi, Mihir","first_name":"Mihir","last_name":"Joshi"},{"full_name":"Thaker, Maria","first_name":"Maria","last_name":"Thaker"}],"date_published":"2024-01-10T00:00:00Z","file":[{"content_type":"application/pdf","access_level":"open_access","checksum":"136325372f6f45abaa62a71e2d23bfb6","relation":"main_file","file_name":"2024_JourExperimBiology_Pal.pdf","creator":"dernst","date_updated":"2024-01-23T12:08:24Z","success":1,"file_id":"14877","date_created":"2024-01-23T12:08:24Z","file_size":594128}],"publication":"Journal of Experimental Biology","supplementarymaterial":"yes","_id":"14850","title":"Too much information? Males convey parasite levels using more signal modalities than females utilise","article_type":"original","date_created":"2024-01-22T08:14:49Z","date_updated":"2026-10-21T08:13:07Z","month":"01","researchdata_availability":"yes","article_processing_charge":"Yes (via OA deal)","publisher":"The Company of Biologists","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","dataavailabilitystatement":"Raw data for this paper are available from Zenodo (doi:10.5281/zenodo.10423540). All analysis code is available from GitHub (https://github.com/arka-pal/Cnemaspis-SexualSignaling)","file_date_updated":"2024-01-23T12:08:24Z","article_number":"jeb246217","quality_controlled":"1","oa":1,"pmid":1,"type":"journal_article","scopus_import":"1","year":"2024","corr_author":"1","department":[{"_id":"NiBa"}]},{"_id":"15358","supplementarymaterial":"yes","file":[{"file_size":1098292,"date_created":"2024-05-13T08:22:21Z","success":1,"file_id":"15383","date_updated":"2024-05-13T08:22:21Z","checksum":"78f36488d24f868d5913624e9c8d88bf","relation":"main_file","creator":"dernst","file_name":"2024_TheorPopulationBiology_Barton.pdf","content_type":"application/pdf","access_level":"open_access"}],"publication":"Theoretical Population Biology","author":[{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240"},{"first_name":"Himani","last_name":"Sachdeva","full_name":"Sachdeva, Himani","id":"42377A0A-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2024-06-01T00:00:00Z","article_processing_charge":"Yes (via OA deal)","date_updated":"2026-10-21T08:14:58Z","month":"06","researchdata_availability":"yes","date_created":"2024-05-05T22:01:03Z","title":"Limits to selection on standing variation in an asexual population","article_type":"original","oa":1,"quality_controlled":"1","page":"129-137","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","dataavailabilitystatement":"Selection_SGV_Asexual (Original data) (GitHub).","file_date_updated":"2024-05-13T08:22:21Z","publisher":"Elsevier","publication_status":"published","department":[{"_id":"NiBa"}],"project":[{"name":"Understanding the evolution of continuous genomes","grant_number":"101055327","_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00"}],"year":"2024","scopus_import":"1","type":"journal_article","corr_author":"1","pmid":1,"language":[{"iso":"eng"}],"isi":1,"abstract":[{"lang":"eng","text":"We consider how a population of N haploid individuals responds to directional selection on standing variation, with no new variation from recombination or mutation. Individuals have trait values z1,…,zN, which are drawn from a distribution ψ; the fitness of individual i is proportional to [Formula: see text] . For illustration, we consider the Laplace and Gaussian distributions, which are parametrised only by the variance V0, and show that for large N, there is a scaling limit which depends on a single parameter NV0. When selection is weak relative to drift (NV0≪1), the variance decreases exponentially at rate 1/N, and the expected ultimate gain in log fitness (scaled by V0), is just NV0, which is the same as Robertson's (1960) prediction for a sexual population. In contrast, when selection is strong relative to drift (NV0≫1), the ultimate gain can be found by approximating the establishment of alleles by a branching process in which each allele competes independently with the population mean and the fittest allele to establish is certain to fix. Then, if the probability of survival to time t∼1/V0 of an allele with value z is P(z), with mean P¯, the winning allele is the fittest of NP¯ survivors drawn from a distribution ψP/P¯. The expected ultimate change is ∼2log(1.15NV0) for a Gaussian distribution, and ∼-12log0.36NV0-log-log0.36NV0 for a Laplace distribution. This approach also predicts the variability of the process, and its dynamics; we show that in the strong selection regime, the expected genetic variance decreases as ∼t-3 at large times. We discuss how these results may be related to selection on standing variation that is spread along a linear chromosome."}],"doi":"10.1016/j.tpb.2024.04.001","publication_identifier":{"eissn":["1096-0325"],"issn":["0040-5809"]},"das_tickbox":"1","volume":157,"ddc":["570"],"fulldoi":"https://doi.org/10.1016/j.tpb.2024.04.001","intvolume":"       157","acknowledgement":"We thank Emmanuel Schertzer and two reviewers for comments on this manuscript. NB thanks the European Research Council for support via the grant “HaplotypeStructure” 101055327. We would also like to give our sincere thanks to Alison Etheridge for her insight, inspiration and support over the years.","citation":{"ieee":"N. H. Barton and H. Sachdeva, “Limits to selection on standing variation in an asexual population,” <i>Theoretical Population Biology</i>, vol. 157. Elsevier, pp. 129–137, 2024.","ama":"Barton NH, Sachdeva H. Limits to selection on standing variation in an asexual population. <i>Theoretical Population Biology</i>. 2024;157:129-137. doi:<a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">10.1016/j.tpb.2024.04.001</a>","chicago":"Barton, Nicholas H, and Himani Sachdeva. “Limits to Selection on Standing Variation in an Asexual Population.” <i>Theoretical Population Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">https://doi.org/10.1016/j.tpb.2024.04.001</a>.","short":"N.H. Barton, H. Sachdeva, Theoretical Population Biology 157 (2024) 129–137.","mla":"Barton, Nicholas H., and Himani Sachdeva. “Limits to Selection on Standing Variation in an Asexual Population.” <i>Theoretical Population Biology</i>, vol. 157, Elsevier, 2024, pp. 129–37, doi:<a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">10.1016/j.tpb.2024.04.001</a>.","ista":"Barton NH, Sachdeva H. 2024. Limits to selection on standing variation in an asexual population. Theoretical Population Biology. 157, 129–137.","apa":"Barton, N. H., &#38; Sachdeva, H. (2024). Limits to selection on standing variation in an asexual population. <i>Theoretical Population Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tpb.2024.04.001\">https://doi.org/10.1016/j.tpb.2024.04.001</a>"},"day":"01","external_id":{"pmid":["38643838"],"isi":["001237016800001"]},"oa_version":"Published Version","has_accepted_license":"1","status":"public","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"}},{"status":"public","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"issue":"4","citation":{"ista":"Johannesson K, Faria R, Le Moan A, Rafajlović M, Westram AM, Butlin RK, Stankowski S. 2024. Diverse pathways to speciation revealed by marine snails. Trends in Genetics. 40(4), 337–351.","apa":"Johannesson, K., Faria, R., Le Moan, A., Rafajlović, M., Westram, A. M., Butlin, R. K., &#38; Stankowski, S. (2024). Diverse pathways to speciation revealed by marine snails. <i>Trends in Genetics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.tig.2024.01.002\">https://doi.org/10.1016/j.tig.2024.01.002</a>","ieee":"K. Johannesson <i>et al.</i>, “Diverse pathways to speciation revealed by marine snails,” <i>Trends in Genetics</i>, vol. 40, no. 4. Elsevier, pp. 337–351, 2024.","chicago":"Johannesson, Kerstin, Rui Faria, Alan Le Moan, Marina Rafajlović, Anja M Westram, Roger K. Butlin, and Sean Stankowski. “Diverse Pathways to Speciation Revealed by Marine Snails.” <i>Trends in Genetics</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.tig.2024.01.002\">https://doi.org/10.1016/j.tig.2024.01.002</a>.","short":"K. Johannesson, R. Faria, A. Le Moan, M. Rafajlović, A.M. Westram, R.K. Butlin, S. Stankowski, Trends in Genetics 40 (2024) 337–351.","ama":"Johannesson K, Faria R, Le Moan A, et al. Diverse pathways to speciation revealed by marine snails. <i>Trends in Genetics</i>. 2024;40(4):337-351. doi:<a href=\"https://doi.org/10.1016/j.tig.2024.01.002\">10.1016/j.tig.2024.01.002</a>","mla":"Johannesson, Kerstin, et al. “Diverse Pathways to Speciation Revealed by Marine Snails.” <i>Trends in Genetics</i>, vol. 40, no. 4, Elsevier, 2024, pp. 337–51, doi:<a href=\"https://doi.org/10.1016/j.tig.2024.01.002\">10.1016/j.tig.2024.01.002</a>."},"day":"01","external_id":{"pmid":["38395682"],"isi":["001224671300001"]},"oa_version":"Published Version","volume":40,"das_tickbox":"0","ddc":["570"],"fulldoi":"https://doi.org/10.1016/j.tig.2024.01.002","acknowledgement":"KJ, MR, and RKB were supported by grants from the Swedish Research Council (2021-0419, 2021-05243, and 2018-03695, respectively). RKB was also supported by the Leverhulme Trust (RPG-2021-141), RF by FCT- Portuguese Science Foundation (PTDC/BIA-EVL/1614/2021 and 2020.00275.CEECIND), and AMW by Norwegian Research Council RCN (Project number 315287). We thank the members of the Integration of Speciation Research network for stimulating discussions, the Littorina research community for important contributions of data and analyses, and Cynthia Riginos for useful comments on an earlier draft.","intvolume":"        40","language":[{"iso":"eng"}],"isi":1,"abstract":[{"text":"Speciation is a key evolutionary process that is not yet fully understood. Combining population genomic and ecological data from multiple diverging pairs of marine snails (Littorina) supports the search for speciation mechanisms. Placing pairs on a one-dimensional speciation continuum, from undifferentiated populations to species, obscured the complexity of speciation. Adding multiple axes helped to describe either speciation routes or reproductive isolation in the snails. Divergent ecological selection repeatedly generated barriers between ecotypes, but appeared less important in completing speciation while genetic incompatibilities played a key role. Chromosomal inversions contributed to genomic barriers, but with variable impact. A multidimensional (hypercube) approach supported framing of questions and identification of knowledge gaps and can be useful to understand speciation in many other systems.","lang":"eng"}],"doi":"10.1016/j.tig.2024.01.002","publication_identifier":{"issn":["0168-9525"],"eissn":["1362-4555"]},"department":[{"_id":"NiBa"}],"scopus_import":"1","year":"2024","type":"journal_article","pmid":1,"oa":1,"quality_controlled":"1","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"337-351","file_date_updated":"2024-07-22T12:05:58Z","publisher":"Elsevier","publication_status":"published","article_processing_charge":"Yes (in subscription journal)","month":"04","date_updated":"2026-10-21T08:13:54Z","researchdata_availability":"no","date_created":"2024-03-10T23:00:54Z","title":"Diverse pathways to speciation revealed by marine snails","article_type":"review","_id":"15099","supplementarymaterial":"yes","file":[{"file_id":"17313","success":1,"date_updated":"2024-07-22T12:05:58Z","date_created":"2024-07-22T12:05:58Z","file_size":2288340,"access_level":"open_access","content_type":"application/pdf","creator":"dernst","file_name":"2024_TrendsGenetics_Johannesson.pdf","relation":"main_file","checksum":"3077ea808c4cdc24d02dc58aced7eb35"}],"publication":"Trends in Genetics","author":[{"full_name":"Johannesson, Kerstin","last_name":"Johannesson","first_name":"Kerstin"},{"full_name":"Faria, Rui","last_name":"Faria","first_name":"Rui"},{"full_name":"Le Moan, Alan","last_name":"Le Moan","first_name":"Alan"},{"full_name":"Rafajlović, Marina","first_name":"Marina","last_name":"Rafajlović"},{"first_name":"Anja M","last_name":"Westram","orcid":"0000-0003-1050-4969","full_name":"Westram, Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Roger K.","last_name":"Butlin","full_name":"Butlin, Roger K."},{"last_name":"Stankowski","first_name":"Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","full_name":"Stankowski, Sean"}],"date_published":"2024-04-01T00:00:00Z"},{"_id":"18949","supplementarymaterial":"yes","file":[{"file_id":"18950","success":1,"date_updated":"2025-01-29T10:52:40Z","file_size":3935454,"date_created":"2025-01-29T10:52:40Z","access_level":"open_access","content_type":"application/pdf","creator":"dernst","file_name":"2024_EvolJourLinneanSoc_Stankowski.pdf","relation":"main_file","checksum":"db08120a92527acaef476bd93f2b87f9"}],"publication":"Evolutionary Journal of the Linnean Society","date_published":"2024-02-16T00:00:00Z","author":[{"id":"43161670-5719-11EA-8025-FABC3DDC885E","full_name":"Stankowski, Sean","last_name":"Stankowski","first_name":"Sean"},{"last_name":"Cutter","first_name":"Asher D","full_name":"Cutter, Asher D"},{"last_name":"Satokangas","first_name":"Ina","full_name":"Satokangas, Ina"},{"last_name":"Lerch","first_name":"Brian A","full_name":"Lerch, Brian A"},{"full_name":"Rolland, Jonathan","last_name":"Rolland","first_name":"Jonathan"},{"first_name":"Carole M","last_name":"Smadja","full_name":"Smadja, Carole M"},{"last_name":"Segami Marzal","first_name":"J Carolina","full_name":"Segami Marzal, J Carolina"},{"last_name":"Cooney","first_name":"Christopher R","full_name":"Cooney, Christopher R"},{"full_name":"Feulner, Philine G D","first_name":"Philine G D","last_name":"Feulner"},{"first_name":"Fabricius Maia Chaves Bicalho","last_name":"Domingos","full_name":"Domingos, Fabricius Maia Chaves Bicalho"},{"full_name":"North, Henry L","last_name":"North","first_name":"Henry L"},{"last_name":"Yamaguchi","first_name":"Ryo","full_name":"Yamaguchi, Ryo"},{"full_name":"Butlin, Roger K","first_name":"Roger K","last_name":"Butlin"},{"last_name":"Wolf","first_name":"Jochen B W","full_name":"Wolf, Jochen B W"},{"first_name":"Jenn","last_name":"Coughlan","full_name":"Coughlan, Jenn"},{"last_name":"Heidbreder","first_name":"Patrick","full_name":"Heidbreder, Patrick"},{"full_name":"Hernández-Gutiérrez, Rebeca","last_name":"Hernández-Gutiérrez","first_name":"Rebeca"},{"last_name":"Barnard-Kubow","first_name":"Karen B","full_name":"Barnard-Kubow, Karen B"},{"last_name":"Peede","first_name":"David","full_name":"Peede, David"},{"last_name":"Rancilhac","first_name":"Loïs","full_name":"Rancilhac, Loïs"},{"full_name":"Salvador, Rodrigo Brincalepe","first_name":"Rodrigo Brincalepe","last_name":"Salvador"},{"first_name":"Ken A","last_name":"Thompson","full_name":"Thompson, Ken A"},{"first_name":"Elizabeth A","last_name":"Stacy","full_name":"Stacy, Elizabeth A"},{"last_name":"Moyle","first_name":"Leonie C","full_name":"Moyle, Leonie C"},{"first_name":"Martin D","last_name":"Garlovsky","full_name":"Garlovsky, Martin D"},{"full_name":"Maulana, Arif","last_name":"Maulana","first_name":"Arif"},{"last_name":"Kantelinen","first_name":"Annina","full_name":"Kantelinen, Annina"},{"full_name":"Cacho, N Ivalú","first_name":"N Ivalú","last_name":"Cacho"},{"full_name":"Schneemann, Hilde","first_name":"Hilde","last_name":"Schneemann"},{"last_name":"Domínguez","first_name":"Marisol","full_name":"Domínguez, Marisol"},{"last_name":"Dopman","first_name":"Erik B","full_name":"Dopman, Erik B"},{"first_name":"Konrad","last_name":"Lohse","full_name":"Lohse, Konrad"},{"last_name":"Rometsch","first_name":"Sina J","full_name":"Rometsch, Sina J"},{"full_name":"Comeault, Aaron A","first_name":"Aaron A","last_name":"Comeault"},{"last_name":"Merrill","first_name":"Richard M","full_name":"Merrill, Richard M"},{"first_name":"Elizabeth S C","last_name":"Scordato","full_name":"Scordato, Elizabeth S C"},{"full_name":"Singhal, Sonal","first_name":"Sonal","last_name":"Singhal"},{"full_name":"Pärssinen, Varpu","last_name":"Pärssinen","first_name":"Varpu"},{"last_name":"Lackey","first_name":"Alycia C R","full_name":"Lackey, Alycia C R"},{"full_name":"Kumar, Sanghamitra","last_name":"Kumar","first_name":"Sanghamitra"},{"full_name":"Meier, Joana I","last_name":"Meier","first_name":"Joana I"},{"orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"},{"last_name":"Fraisse","orcid":"0000-0001-8441-5075","first_name":"Christelle","id":"32DF5794-F248-11E8-B48F-1D18A9856A87","full_name":"Fraisse, Christelle"},{"last_name":"Ravinet","first_name":"Mark","full_name":"Ravinet, Mark"},{"full_name":"Kulmuni, Jonna","last_name":"Kulmuni","first_name":"Jonna"}],"article_processing_charge":"Yes","month":"02","date_updated":"2026-10-21T08:21:06Z","researchdata_availability":"no","date_created":"2025-01-29T10:38:17Z","title":"Toward the integration of speciation research","article_type":"original","OA_place":"publisher","quality_controlled":"1","oa":1,"article_number":"kzae001","file_date_updated":"2025-01-29T10:52:40Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","publisher":"Oxford University Press","department":[{"_id":"NiBa"}],"OA_type":"gold","corr_author":"1","type":"journal_article","scopus_import":"1","year":"2024","license":"https://creativecommons.org/licenses/by-nc/4.0/","language":[{"iso":"eng"}],"abstract":[{"text":"Speciation research—the scientific field focused on understanding the origin and diversity of species—has a long and complex history. While relevant to one another, the specific goals and activities of speciation researchers are highly diverse, and scattered across a collection of different perspectives. Thus, our understanding of speciation will benefit from efforts to bridge scientific findings and the diverse people who do the work. In this paper, we outline two ways of integrating speciation research: (i) scientific integration, through the bringing together of ideas, data, and approaches; and (ii) social integration, by creating ways for a diversity of researchers to participate in the scientific process. We then discuss five challenges to integration: (i) the multidisciplinary nature of speciation research, (ii) the complex language of speciation; (iii) a bias toward certain study systems; (iv) the challenges of working across scales; and (v) inconsistent measures and reporting standards. We provide practical steps that individuals and groups can take to help overcome these challenges, and argue that integration is a team effort in which we all have a role to play.","lang":"eng"}],"doi":"10.1093/evolinnean/kzae001","publication_identifier":{"issn":["2752-938X"]},"volume":3,"das_tickbox":"0","ddc":["570"],"fulldoi":"https://doi.org/10.1093/evolinnean/kzae001","acknowledgement":"We thank the staff of the Tvärminne Zoological Station (University of Helsinki) for their hospitality during the workshop. We are also grateful to everyone who applied to attend the workshop.\r\nFunding for the workshop was provided by the European Society for Evolutionary Biology through the Special Topic Network (STN) funding scheme.","intvolume":"         3","issue":"1","citation":{"ieee":"S. Stankowski <i>et al.</i>, “Toward the integration of speciation research,” <i>Evolutionary Journal of the Linnean Society</i>, vol. 3, no. 1. Oxford University Press, 2024.","chicago":"Stankowski, Sean, Asher D Cutter, Ina Satokangas, Brian A Lerch, Jonathan Rolland, Carole M Smadja, J Carolina Segami Marzal, et al. “Toward the Integration of Speciation Research.” <i>Evolutionary Journal of the Linnean Society</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/evolinnean/kzae001\">https://doi.org/10.1093/evolinnean/kzae001</a>.","short":"S. Stankowski, A.D. Cutter, I. Satokangas, B.A. Lerch, J. Rolland, C.M. Smadja, J.C. Segami Marzal, C.R. Cooney, P.G.D. Feulner, F.M.C.B. Domingos, H.L. North, R. Yamaguchi, R.K. Butlin, J.B.W. Wolf, J. Coughlan, P. Heidbreder, R. Hernández-Gutiérrez, K.B. Barnard-Kubow, D. Peede, L. Rancilhac, R.B. Salvador, K.A. Thompson, E.A. Stacy, L.C. Moyle, M.D. Garlovsky, A. Maulana, A. Kantelinen, N.I. Cacho, H. Schneemann, M. Domínguez, E.B. Dopman, K. Lohse, S.J. Rometsch, A.A. Comeault, R.M. Merrill, E.S.C. Scordato, S. Singhal, V. Pärssinen, A.C.R. Lackey, S. Kumar, J.I. Meier, N.H. Barton, C. Fraisse, M. Ravinet, J. Kulmuni, Evolutionary Journal of the Linnean Society 3 (2024).","ama":"Stankowski S, Cutter AD, Satokangas I, et al. Toward the integration of speciation research. <i>Evolutionary Journal of the Linnean Society</i>. 2024;3(1). doi:<a href=\"https://doi.org/10.1093/evolinnean/kzae001\">10.1093/evolinnean/kzae001</a>","mla":"Stankowski, Sean, et al. “Toward the Integration of Speciation Research.” <i>Evolutionary Journal of the Linnean Society</i>, vol. 3, no. 1, kzae001, Oxford University Press, 2024, doi:<a href=\"https://doi.org/10.1093/evolinnean/kzae001\">10.1093/evolinnean/kzae001</a>.","ista":"Stankowski S, Cutter AD, Satokangas I, Lerch BA, Rolland J, Smadja CM, Segami Marzal JC, Cooney CR, Feulner PGD, Domingos FMCB, North HL, Yamaguchi R, Butlin RK, Wolf JBW, Coughlan J, Heidbreder P, Hernández-Gutiérrez R, Barnard-Kubow KB, Peede D, Rancilhac L, Salvador RB, Thompson KA, Stacy EA, Moyle LC, Garlovsky MD, Maulana A, Kantelinen A, Cacho NI, Schneemann H, Domínguez M, Dopman EB, Lohse K, Rometsch SJ, Comeault AA, Merrill RM, Scordato ESC, Singhal S, Pärssinen V, Lackey ACR, Kumar S, Meier JI, Barton NH, Fraisse C, Ravinet M, Kulmuni J. 2024. Toward the integration of speciation research. Evolutionary Journal of the Linnean Society. 3(1), kzae001.","apa":"Stankowski, S., Cutter, A. D., Satokangas, I., Lerch, B. A., Rolland, J., Smadja, C. M., … Kulmuni, J. (2024). Toward the integration of speciation research. <i>Evolutionary Journal of the Linnean Society</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evolinnean/kzae001\">https://doi.org/10.1093/evolinnean/kzae001</a>"},"day":"16","oa_version":"Published Version","status":"public","has_accepted_license":"1","tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"}},{"publication_status":"published","publisher":"Oxford University Press","dataavailabilitystatement":"The raw fasta files are available on NCBI SRA under the project name “Littorina fabalis transect WGS” with accession number PRJNA836378. The filtered vcf file, metadata, as well as the R scripts used to analyse these datasets, are available as a zenodo archive here: doi: 10.5281/zenodo.10790257.","file_date_updated":"2025-01-27T13:33:14Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"575-586","OA_place":"publisher","oa":1,"quality_controlled":"1","pmid":1,"type":"journal_article","year":"2024","scopus_import":"1","OA_type":"gold","department":[{"_id":"NiBa"}],"date_published":"2024-04-23T00:00:00Z","author":[{"last_name":"Le Moan","first_name":"Alan","full_name":"Le Moan, Alan"},{"last_name":"Stankowski","first_name":"Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","full_name":"Stankowski, Sean"},{"first_name":"Marina","last_name":"Rafajlović","full_name":"Rafajlović, Marina"},{"full_name":"Ortega-Martinez, Olga","first_name":"Olga","last_name":"Ortega-Martinez"},{"full_name":"Faria, Rui","last_name":"Faria","first_name":"Rui"},{"first_name":"Roger K","last_name":"Butlin","full_name":"Butlin, Roger K"},{"first_name":"Kerstin","last_name":"Johannesson","full_name":"Johannesson, Kerstin"}],"publication":"Evolution Letters","file":[{"date_updated":"2025-01-27T13:33:14Z","success":1,"file_id":"18909","file_size":24356661,"date_created":"2025-01-27T13:33:14Z","content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"2f7780b7b6b3489755f1815f476639c6","creator":"dernst","file_name":"2024_EvolutionLetter_Moan.pdf"}],"supplementarymaterial":"yes","_id":"18908","title":"Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes","article_type":"letter_note","date_created":"2025-01-27T13:30:27Z","researchdata_availability":"yes","date_updated":"2026-10-21T08:20:21Z","month":"04","article_processing_charge":"Yes","oa_version":"Published Version","external_id":{"isi":["001206532900001"],"pmid":["39479507"]},"day":"23","citation":{"mla":"Le Moan, Alan, et al. “Coupling of Twelve Putative Chromosomal Inversions Maintains a Strong Barrier to Gene Flow between Snail Ecotypes.” <i>Evolution Letters</i>, vol. 8, no. 4, Oxford University Press, 2024, pp. 575–86, doi:<a href=\"https://doi.org/10.1093/evlett/qrae014\">10.1093/evlett/qrae014</a>.","ieee":"A. Le Moan <i>et al.</i>, “Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes,” <i>Evolution Letters</i>, vol. 8, no. 4. Oxford University Press, pp. 575–586, 2024.","ama":"Le Moan A, Stankowski S, Rafajlović M, et al. Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes. <i>Evolution Letters</i>. 2024;8(4):575-586. doi:<a href=\"https://doi.org/10.1093/evlett/qrae014\">10.1093/evlett/qrae014</a>","chicago":"Le Moan, Alan, Sean Stankowski, Marina Rafajlović, Olga Ortega-Martinez, Rui Faria, Roger K Butlin, and Kerstin Johannesson. “Coupling of Twelve Putative Chromosomal Inversions Maintains a Strong Barrier to Gene Flow between Snail Ecotypes.” <i>Evolution Letters</i>. Oxford University Press, 2024. <a href=\"https://doi.org/10.1093/evlett/qrae014\">https://doi.org/10.1093/evlett/qrae014</a>.","short":"A. Le Moan, S. Stankowski, M. Rafajlović, O. Ortega-Martinez, R. Faria, R.K. Butlin, K. Johannesson, Evolution Letters 8 (2024) 575–586.","apa":"Le Moan, A., Stankowski, S., Rafajlović, M., Ortega-Martinez, O., Faria, R., Butlin, R. K., &#38; Johannesson, K. (2024). Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes. <i>Evolution Letters</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/evlett/qrae014\">https://doi.org/10.1093/evlett/qrae014</a>","ista":"Le Moan A, Stankowski S, Rafajlović M, Ortega-Martinez O, Faria R, Butlin RK, Johannesson K. 2024. Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes. Evolution Letters. 8(4), 575–586."},"issue":"4","tmp":{"short":"CC BY-NC (4.0)","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","image":"/images/cc_by_nc.png","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode"},"has_accepted_license":"1","status":"public","publication_identifier":{"issn":["2056-3744"]},"doi":"10.1093/evlett/qrae014","abstract":[{"text":"Chromosomal rearrangements can lead to the coupling of reproductive barriers, but whether and how they contribute to the completion of speciation remains unclear. Marine snails of the genus Littorina repeatedly form hybrid zones between populations segregating for multiple inversion arrangements, providing opportunities to study their barrier effects. Here, we analyzed 2 adjacent transects across hybrid zones between 2 ecotypes of Littorina fabalis (“large” and “dwarf”) adapted to different wave exposure conditions on a Swedish island. Applying whole-genome sequencing, we found 12 putative inversions on 9 of 17 chromosomes. Nine of the putative inversions reached near differential fixation between the 2 ecotypes, and all were in strong linkage disequilibrium. These inversions cover 20% of the genome and carry 93% of divergent single nucleotide polymorphisms (SNPs). Bimodal hybrid zones in both transects indicated that the 2 ecotypes of Littorina fabalis maintain their genetic and phenotypic integrity following contact. The bimodality reflects the strong coupling between inversion clines and the extension of the barrier effect across the whole genome. Demographic inference suggests that coupling arose during a period of allopatry and has been maintained for &amp;gt; 1,000 generations after secondary contact. Overall, this study shows that the coupling of multiple chromosomal inversions contributes to strong reproductive isolation. Notably, 2 of the putative inversions overlap with inverted genomic regions associated with ecotype differences in a closely related species (Littorina saxatilis), suggesting the same regions, with similar structural variants, repeatedly contribute to ecotype evolution in distinct species.","lang":"eng"}],"isi":1,"language":[{"iso":"eng"}],"intvolume":"         8","acknowledgement":"The computations and data handling were enabled by resources provided by the Swedish National Infrastructure for Computing at UPPMAX partially funded by the Swedish Research Council through grant agreement no. 2018-05973. We thank all the member of the Littorina team for the stimulating discussions about the manuscripts, James Reeves for his help the implementation of Hsplit, and Thomas Broquet for his useful comments in the latter stage of manuscript revisions.","related_material":{"record":[{"status":"public","id":"22870","relation":"research_data"}]},"fulldoi":"https://doi.org/10.1093/evlett/qrae014","ddc":["570"],"das_tickbox":"1","volume":8},{"tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1","external_id":{"isi":["001354405400018"]},"oa_version":"Published Version","DOAJ_listed":"1","day":"11","citation":{"mla":"Garcia Castillo, Diego Fernando, et al. “Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” <i>Science Advances</i>, vol. 10, no. 41, eadp2102, AAAS, 2024, doi:<a href=\"https://doi.org/10.1126/sciadv.adp2102\">10.1126/sciadv.adp2102</a>.","ama":"Garcia Castillo DF, Barton NH, Faria R, et al. Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails. <i>Science Advances</i>. 2024;10(41). doi:<a href=\"https://doi.org/10.1126/sciadv.adp2102\">10.1126/sciadv.adp2102</a>","chicago":"Garcia Castillo, Diego Fernando, Nicholas H Barton, Rui Faria, Jenny Larsson, Sean Stankowski, Roger Butlin, Kerstin Johannesson, and Anja M Westram. “Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” <i>Science Advances</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/sciadv.adp2102\">https://doi.org/10.1126/sciadv.adp2102</a>.","short":"D.F. Garcia Castillo, N.H. Barton, R. Faria, J. Larsson, S. Stankowski, R. Butlin, K. Johannesson, A.M. Westram, Science Advances 10 (2024).","ieee":"D. F. Garcia Castillo <i>et al.</i>, “Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails,” <i>Science Advances</i>, vol. 10, no. 41. AAAS, 2024.","apa":"Garcia Castillo, D. F., Barton, N. H., Faria, R., Larsson, J., Stankowski, S., Butlin, R., … Westram, A. M. (2024). Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails. <i>Science Advances</i>. AAAS. <a href=\"https://doi.org/10.1126/sciadv.adp2102\">https://doi.org/10.1126/sciadv.adp2102</a>","ista":"Garcia Castillo DF, Barton NH, Faria R, Larsson J, Stankowski S, Butlin R, Johannesson K, Westram AM. 2024. Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails. Science Advances. 10(41), eadp2102."},"issue":"41","acknowledgement":"This work was received funding from the following: Norwegian Research Council RCN project 315287 (A.M.W.), Swedish Research Council 2021-04191 (K.J.), European Research Council grant 101055327 HaplotypeStructure (N.B.), Austrian Science Fund FWF; P 32166-B32 Snapdragon Speciation (N.B.), European Research Council (R.B.), and Portuguese Foundation for Science and Technology FCT: 2020.00275.CEECIND and PTDC/BIA-EVL/1614/2021 (R.F.).","intvolume":"        10","fulldoi":"https://doi.org/10.1126/sciadv.adp2102","PlanS_conform":"1","related_material":{"record":[{"relation":"research_data","id":"18498","status":"public"},{"status":"public","id":"20991","relation":"dissertation_contains"}],"link":[{"relation":"software","url":"https://github.com/fernandoGarcia21/littorina_saxatilis_skerry"}]},"ddc":["570"],"volume":10,"das_tickbox":"1","publication_identifier":{"eissn":["2375-2548"]},"doi":"10.1126/sciadv.adp2102","isi":1,"abstract":[{"text":"Predicting the outcomes of adaptation is a major goal of evolutionary biology. When temporal changes in the environment mirror spatial gradients, it opens up the potential for predicting the course of adaptive evolution over time based on patterns of spatial genetic and phenotypic variation. We assessed this approach in a 30-year transplant experiment in the intertidal snail Littorina saxatilis. In 1992, snails were transplanted from a predation-dominated environment to one dominated by wave action. On the basis of spatial patterns, we predicted transitions in shell size and morphology, allele frequencies at positions throughout the genome, and chromosomal rearrangement frequencies. Observed changes closely agreed with predictions and transformation was both dramatic and rapid. Hence, adaptation can be predicted from knowledge of the phenotypic and genetic variation among populations.","lang":"eng"}],"language":[{"iso":"eng"}],"scopus_import":"1","type":"journal_article","year":"2024","corr_author":"1","OA_type":"gold","department":[{"_id":"NiBa"}],"project":[{"_id":"bd6958e0-d553-11ed-ba76-86eba6a76c00","grant_number":"101055327","name":"Understanding the evolution of continuous genomes"},{"name":"Snapdragon Speciation","grant_number":"P32166","_id":"05959E1C-7A3F-11EA-A408-12923DDC885E"},{"_id":"3AC91DDA-15DF-11EA-824D-93A3E7B544D1","name":"FWF Open Access Fund","call_identifier":"FWF"}],"publisher":"AAAS","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","dataavailabilitystatement":"All analysis scripts and data needed to evaluate the conclusions of the paper are present in the paper and/or the Supplementary Materials and have been archived on Zenodo (63) at https://zenodo.org/doi/10.5281/zenodo.12159343 and are available on Github at https://github.com/fernandoGarcia21/littorina_saxatilis_skerry.","file_date_updated":"2024-11-04T09:35:49Z","article_number":"eadp2102","oa":1,"quality_controlled":"1","OA_place":"publisher","article_type":"original","title":"Predicting rapid adaptation in time from adaptation in space: A 30-year field experiment in marine snails","date_created":"2024-11-03T23:01:44Z","researchdata_availability":"yes (supplementary data)","month":"10","date_updated":"2026-10-21T08:18:22Z","article_processing_charge":"Yes","author":[{"full_name":"Garcia Castillo, Diego Fernando","id":"ae681a14-dc74-11ea-a0a7-c6ef18161701","first_name":"Diego Fernando","last_name":"Garcia Castillo"},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","last_name":"Barton"},{"last_name":"Faria","first_name":"Rui","full_name":"Faria, Rui"},{"full_name":"Larsson, Jenny","last_name":"Larsson","first_name":"Jenny"},{"last_name":"Stankowski","first_name":"Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E","full_name":"Stankowski, Sean"},{"full_name":"Butlin, Roger","first_name":"Roger","last_name":"Butlin"},{"full_name":"Johannesson, Kerstin","last_name":"Johannesson","first_name":"Kerstin"},{"last_name":"Westram","orcid":"0000-0003-1050-4969","first_name":"Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M"}],"date_published":"2024-10-11T00:00:00Z","publication":"Science Advances","APC_amount":"4569,23 EUR","file":[{"content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"96aa0d3640fa9401975138e59054f84e","creator":"dernst","file_name":"2024_ScienceAdv_Castillo.pdf","date_updated":"2024-11-04T09:35:49Z","success":1,"file_id":"18499","date_created":"2024-11-04T09:35:49Z","file_size":1154107}],"supplementarymaterial":"yes","_id":"18491"},{"year":"2024","scopus_import":"1","type":"journal_article","OA_type":"hybrid","department":[{"_id":"NiBa"}],"pmid":1,"oa":1,"quality_controlled":"1","article_number":"e17160","OA_place":"publisher","publisher":"Wiley","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","file_date_updated":"2025-01-09T07:52:12Z","dataavailabilitystatement":"All raw sequence data were uploaded to the NCBI short read archive (PRJNA626520). All scripts used for this project are uploaded to GitHub (https://github.com/ja-Reeve/Littorina_inversion_identification.git).","researchdata_availability":"yes","date_updated":"2026-10-21T08:19:22Z","month":"12","article_processing_charge":"Yes (in subscription journal)","article_type":"original","title":"Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana)","date_created":"2023-10-29T23:01:17Z","supplementarymaterial":"yes","_id":"14463","author":[{"first_name":"James","last_name":"Reeve","full_name":"Reeve, James"},{"full_name":"Butlin, Roger K.","first_name":"Roger K.","last_name":"Butlin"},{"last_name":"Koch","first_name":"Eva L.","full_name":"Koch, Eva L."},{"first_name":"Sean","last_name":"Stankowski","full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E"},{"full_name":"Faria, Rui","first_name":"Rui","last_name":"Faria"}],"date_published":"2024-12-01T00:00:00Z","file":[{"access_level":"open_access","content_type":"application/pdf","file_name":"2024_MolecularEcology_Reeve.pdf","creator":"dernst","relation":"main_file","checksum":"686576036663f489c2d079df3079d126","file_id":"18785","success":1,"date_updated":"2025-01-09T07:52:12Z","date_created":"2025-01-09T07:52:12Z","file_size":6228700}],"publication":"Molecular Ecology","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","has_accepted_license":"1","citation":{"mla":"Reeve, James, et al. “Chromosomal Inversion Polymorphisms Are Widespread across the Species Ranges of Rough Periwinkles (Littorina Saxatilis and L. Arcana).” <i>Molecular Ecology</i>, vol. 33, no. 24, e17160, Wiley, 2024, doi:<a href=\"https://doi.org/10.1111/mec.17160\">10.1111/mec.17160</a>.","chicago":"Reeve, James, Roger K. Butlin, Eva L. Koch, Sean Stankowski, and Rui Faria. “Chromosomal Inversion Polymorphisms Are Widespread across the Species Ranges of Rough Periwinkles (Littorina Saxatilis and L. Arcana).” <i>Molecular Ecology</i>. Wiley, 2024. <a href=\"https://doi.org/10.1111/mec.17160\">https://doi.org/10.1111/mec.17160</a>.","ama":"Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). <i>Molecular Ecology</i>. 2024;33(24). doi:<a href=\"https://doi.org/10.1111/mec.17160\">10.1111/mec.17160</a>","short":"J. Reeve, R.K. Butlin, E.L. Koch, S. Stankowski, R. Faria, Molecular Ecology 33 (2024).","ieee":"J. Reeve, R. K. Butlin, E. L. Koch, S. Stankowski, and R. Faria, “Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana),” <i>Molecular Ecology</i>, vol. 33, no. 24. Wiley, 2024.","apa":"Reeve, J., Butlin, R. K., Koch, E. L., Stankowski, S., &#38; Faria, R. (2024). Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.17160\">https://doi.org/10.1111/mec.17160</a>","ista":"Reeve J, Butlin RK, Koch EL, Stankowski S, Faria R. 2024. Chromosomal inversion polymorphisms are widespread across the species ranges of rough periwinkles (Littorina saxatilis and L. arcana). Molecular Ecology. 33(24), e17160."},"issue":"24","external_id":{"pmid":["37843465"],"isi":["001085119000001"]},"oa_version":"Published Version","day":"01","ddc":["570"],"volume":33,"das_tickbox":"1","acknowledgement":"We would like to thank members of the Littorina team for their advice and feedback during this project. In particular, we thank Alan Le Moan, who inspired us to look at heterozygosity differences to identify inversions, and Katherine Hearn for helping with the PCA scripts. We thank Edinburgh Genomics for library preparation and sequencing. Sample collections, sequencing and data preparation were supported by the European Research Council (ERC-2015-AdG-693030- BARRIERS) and the Natural Environment Research Council (NE/P001610/1). The analysis was supported by the Swedish Research Council (vetenskaprådet; 2018-03695_VR) and the Portuguese Foundation for Science and Technology (Fundación para a Ciência e Tecnologia) through a research project (PTDC/BIA-EVL/1614/2021) and CEEC contract (2020.00275.CEECIND).","intvolume":"        33","fulldoi":"https://doi.org/10.1111/mec.17160","isi":1,"abstract":[{"lang":"eng","text":"Inversions are thought to play a key role in adaptation and speciation, suppressing recombination between diverging populations. Genes influencing adaptive traits cluster in inversions, and changes in inversion frequencies are associated with environmental differences. However, in many organisms, it is unclear if inversions are geographically and taxonomically widespread. The intertidal snail, Littorina saxatilis, is one such example. Strong associations between putative polymorphic inversions and phenotypic differences have been demonstrated between two ecotypes of L. saxatilis in Sweden and inferred elsewhere, but no direct evidence for inversion polymorphism currently exists across the species range. Using whole genome data from 107 snails, most inversion polymorphisms were found to be widespread across the species range. The frequencies of some inversion arrangements were significantly different among ecotypes, suggesting a parallel adaptive role. Many inversions were also polymorphic in the sister species, L. arcana, hinting at an ancient origin."}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0962-1083"],"eissn":["1365-294X"]},"doi":"10.1111/mec.17160"},{"publication_identifier":{"eissn":["1616-1599"],"issn":["0171-8630"]},"doi":"10.3354/meps14640","abstract":[{"text":"Understanding connectivity patterns exhibited by endangered species living in fragmented habitats is fundamental to improving management and conservation actions. Such improvements can be particularly pressing at the trailing edges of these habitats, where populations are facing the greatest challenges from climate change, and appear even more crucial if the species is commercially harvested. Seascape genetics have been increasingly used to meet these needs. In this study, we examined connectivity patterns among 32 populations of the oarweed kelp <jats:italic>Lam</jats:italic><jats:italic>inaria digitata</jats:italic> located at the species’ southern range limit. The distance (or sampling gap) between neighboring populations ranged from a few km to a few 100s of km. By genotyping 11 microsatellite markers, we aimed to (1) refine analyses of population structure; (2) test whether on-shelf islands are genetically more differentiated than mainland populations; (3) evaluate the relative importance of various abiotic conditions in shaping the genetic structure; and (4) evaluate if the relative importance of each environmental factor varied according to sampling schemes. Our analyses revealed a positive relationship between connectivity links and genetic diversity: populations with high levels of connectivity were genetically enriched while isolated populations showed signs of genetic erosion. The genetically impoverished populations corresponded to the southernmost populations as well as populations along the northern coast of Brittany (Locquirec, Saint-Malo Bay) and the northernmost population in Pas-de-Calais. By performing distance-based redundancy analysis on various sampling schemes, geographic distance appeared as the dominant factor influencing connectivity between populations separated by great distances, while hydrodynamic processes were the main factor when analyzing at a final spatial resolution.","lang":"eng"}],"language":[{"iso":"eng"}],"intvolume":"       740","fulldoi":"https://doi.org/10.3354/meps14640","volume":740,"oa_version":"Submitted Version","main_file_link":[{"url":"https://inria.hal.science/hal-04624490/","open_access":"1"}],"day":"25","citation":{"ista":"Fouqueau L, Reynes L, Tempera F, Bajjouk T, Blanfuné A, Chevalier C, Laurans M, Mauger S, Sourisseau M, Assis J, Lévêque L, Valero M. 2024. Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes. Marine Ecology Progress Series. 740, 23–42.","apa":"Fouqueau, L., Reynes, L., Tempera, F., Bajjouk, T., Blanfuné, A., Chevalier, C., … Valero, M. (2024). Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes. <i>Marine Ecology Progress Series</i>. Inter-Research Science Center. <a href=\"https://doi.org/10.3354/meps14640\">https://doi.org/10.3354/meps14640</a>","ama":"Fouqueau L, Reynes L, Tempera F, et al. Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes. <i>Marine Ecology Progress Series</i>. 2024;740:23-42. doi:<a href=\"https://doi.org/10.3354/meps14640\">10.3354/meps14640</a>","chicago":"Fouqueau, Louise, L Reynes, F Tempera, T Bajjouk, A Blanfuné, C Chevalier, M Laurans, et al. “Seascape Genetic Study on Laminaria Digitata Underscores the Critical Role of Sampling Schemes.” <i>Marine Ecology Progress Series</i>. Inter-Research Science Center, 2024. <a href=\"https://doi.org/10.3354/meps14640\">https://doi.org/10.3354/meps14640</a>.","short":"L. Fouqueau, L. Reynes, F. Tempera, T. Bajjouk, A. Blanfuné, C. Chevalier, M. Laurans, S. Mauger, M. Sourisseau, J. Assis, L. Lévêque, M. Valero, Marine Ecology Progress Series 740 (2024) 23–42.","ieee":"L. Fouqueau <i>et al.</i>, “Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes,” <i>Marine Ecology Progress Series</i>, vol. 740. Inter-Research Science Center, pp. 23–42, 2024.","mla":"Fouqueau, Louise, et al. “Seascape Genetic Study on Laminaria Digitata Underscores the Critical Role of Sampling Schemes.” <i>Marine Ecology Progress Series</i>, vol. 740, Inter-Research Science Center, 2024, pp. 23–42, doi:<a href=\"https://doi.org/10.3354/meps14640\">10.3354/meps14640</a>."},"status":"public","author":[{"full_name":"Fouqueau, Louise","id":"1676e173-8143-11ed-8927-fe165216a93f","first_name":"Louise","orcid":"0000-0003-0371-9339","last_name":"Fouqueau"},{"full_name":"Reynes, L","last_name":"Reynes","first_name":"L"},{"last_name":"Tempera","first_name":"F","full_name":"Tempera, F"},{"full_name":"Bajjouk, T","first_name":"T","last_name":"Bajjouk"},{"full_name":"Blanfuné, A","last_name":"Blanfuné","first_name":"A"},{"full_name":"Chevalier, C","first_name":"C","last_name":"Chevalier"},{"full_name":"Laurans, M","last_name":"Laurans","first_name":"M"},{"full_name":"Mauger, S","first_name":"S","last_name":"Mauger"},{"first_name":"M","last_name":"Sourisseau","full_name":"Sourisseau, M"},{"last_name":"Assis","first_name":"J","full_name":"Assis, J"},{"first_name":"L","last_name":"Lévêque","full_name":"Lévêque, L"},{"first_name":"M","last_name":"Valero","full_name":"Valero, M"}],"date_published":"2024-07-25T00:00:00Z","publication":"Marine Ecology Progress Series","supplementarymaterial":"yes","_id":"18944","article_type":"original","title":"Seascape genetic study on Laminaria digitata underscores the critical role of sampling schemes","date_created":"2025-01-29T09:09:10Z","month":"07","researchdata_availability":"unclear","date_updated":"2026-10-21T08:20:48Z","article_processing_charge":"No","publisher":"Inter-Research Science Center","publication_status":"published","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"23-42","quality_controlled":"1","oa":1,"OA_place":"repository","year":"2024","type":"journal_article","scopus_import":"1","corr_author":"1","department":[{"_id":"NiBa"}],"OA_type":"green"},{"OA_type":"green","status":"public","department":[{"_id":"NiBa"}],"year":"2024","type":"research_data_reference","day":"06","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5281/zenodo.10790257"}],"oa_version":"None","publisher":"Repository","OA_place":"repository","citation":{"ieee":"A. Le Moan, “Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes.” Repository, 2024.","ama":"Le Moan A. Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes. 2024. doi:<a href=\"https://doi.org/10.5281/zenodo.10790257\">10.5281/zenodo.10790257</a>","short":"A. Le Moan, (2024).","chicago":"Le Moan, Alan. “Coupling of Twelve Putative Chromosomal Inversions Maintains a Strong Barrier to Gene Flow between Snail Ecotypes.” Repository, 2024. <a href=\"https://doi.org/10.5281/zenodo.10790257\">https://doi.org/10.5281/zenodo.10790257</a>.","mla":"Le Moan, Alan. <i>Coupling of Twelve Putative Chromosomal Inversions Maintains a Strong Barrier to Gene Flow between Snail Ecotypes</i>. Repository, 2024, doi:<a href=\"https://doi.org/10.5281/zenodo.10790257\">10.5281/zenodo.10790257</a>.","ista":"Le Moan A. 2024. Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes, Repository, <a href=\"https://doi.org/10.5281/zenodo.10790257\">10.5281/zenodo.10790257</a>.","apa":"Le Moan, A. (2024). Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes. Repository. <a href=\"https://doi.org/10.5281/zenodo.10790257\">https://doi.org/10.5281/zenodo.10790257</a>"},"oa":1,"date_created":"2026-09-09T10:39:08Z","related_material":{"record":[{"relation":"used_in_publication","id":"18908","status":"public"}]},"fulldoi":"https://doi.org/10.5281/zenodo.10790257","title":"Coupling of twelve putative chromosomal inversions maintains a strong barrier to gene flow between snail ecotypes","article_processing_charge":"No","ddc":["570"],"month":"03","date_updated":"2026-10-21T08:20:20Z","doi":"10.5281/zenodo.10790257","date_published":"2024-03-06T00:00:00Z","author":[{"last_name":"Le Moan","first_name":"Alan","full_name":"Le Moan, Alan"}],"_id":"22870","contributor":[{"first_name":"Alan","last_name":"Le Moan","contributor_type":"contact_person"}],"abstract":[{"lang":"eng","text":"Abstract: Chromosomal rearrangements can lead to the coupling of reproductive barriers, but whether and how they contribute to completion of speciation remains unclear. Marine snails of the genus Littorina repeatedly form hybrid zones between populations segregating for multiple inversion arrangements, providing opportunities to study their barrier effects. Here, we analysed two adjacent transects across hybrid zones between two ecotypes of Littorina fabalis (‘large’ and ‘dwarf’) adapted to different wave exposure conditions on a Swedish island. Applying whole-genome sequencing, we found 12 putative inversions on nine of 17 chromosomes. Nine of the putative inversions reached near differential fixation between the two ecotypes, and all were in strong linkage disequilibrium. These inversions cover 20% of the genome and carry 93% of divergent single nucleotide polymorphisms (SNPs). Bimodal hybrid zones in both transects indicated that the two ecotypes of Littorina fabalis maintain their genetic and phenotypic integrity following contact. The bimodality reflects the strong coupling between inversion clines and the extension of the barrier effect across the whole genome. Demographic inference suggests that coupling arose during a period of allopatry and has been maintained for >1000 generations after secondary contact. Overall, this study shows that the coupling of multiple chromosomal inversions contributes to strong reproductive isolation. Notably, two of the putative inversions overlap with inverted genomic regions associated with ecotype differences in a closely-related species (Littorina saxatilis), suggesting the same regions, with similar structural variants, repeatedly contribute to ecotype evolution in distinct species."}]},{"month":"06","date_updated":"2026-10-21T08:18:21Z","ddc":["570"],"article_processing_charge":"No","title":"Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails","fulldoi":"https://doi.org/10.5281/ZENODO.12159343","date_created":"2024-11-04T09:33:17Z","related_material":{"record":[{"id":"20991","relation":"used_in_publication","status":"public"},{"relation":"used_in_publication","id":"18491","status":"public"}]},"abstract":[{"lang":"eng","text":"Scripts and data used in the research study Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails. https://doi.org/10.1101/2023.09.27.559715"}],"_id":"18498","author":[{"last_name":"Garcia Castillo","first_name":"Diego Fernando","id":"ae681a14-dc74-11ea-a0a7-c6ef18161701","full_name":"Garcia Castillo, Diego Fernando"},{"first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Faria","first_name":"Rui","full_name":"Faria, Rui"},{"full_name":"Larsson, Jenny","first_name":"Jenny","last_name":"Larsson"},{"first_name":"Sean","last_name":"Stankowski","full_name":"Stankowski, Sean","id":"43161670-5719-11EA-8025-FABC3DDC885E"},{"full_name":"Butlin, Roger","last_name":"Butlin","first_name":"Roger"},{"first_name":"Kerstin","last_name":"Johannesson","full_name":"Johannesson, Kerstin"},{"orcid":"0000-0003-1050-4969","last_name":"Westram","first_name":"Anja M","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M"}],"date_published":"2024-06-19T00:00:00Z","doi":"10.5281/ZENODO.12159343","type":"research_data_reference","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"year":"2024","corr_author":"1","department":[{"_id":"NiBa"}],"has_accepted_license":"1","status":"public","citation":{"apa":"Garcia Castillo, D. F., Barton, N. H., Faria, R., Larsson, J., Stankowski, S., Butlin, R., … Westram, A. M. (2024). Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails. Zenodo. <a href=\"https://doi.org/10.5281/ZENODO.12159343\">https://doi.org/10.5281/ZENODO.12159343</a>","ista":"Garcia Castillo DF, Barton NH, Faria R, Larsson J, Stankowski S, Butlin R, Johannesson K, Westram AM. 2024. Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails, Zenodo, <a href=\"https://doi.org/10.5281/ZENODO.12159343\">10.5281/ZENODO.12159343</a>.","mla":"Garcia Castillo, Diego Fernando, et al. <i>Data and Code for: Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails</i>. Zenodo, 2024, doi:<a href=\"https://doi.org/10.5281/ZENODO.12159343\">10.5281/ZENODO.12159343</a>.","chicago":"Garcia Castillo, Diego Fernando, Nicholas H Barton, Rui Faria, Jenny Larsson, Sean Stankowski, Roger Butlin, Kerstin Johannesson, and Anja M Westram. “Data and Code for: Predicting Rapid Adaptation in Time from Adaptation in Space: A 30-Year Field Experiment in Marine Snails.” Zenodo, 2024. <a href=\"https://doi.org/10.5281/ZENODO.12159343\">https://doi.org/10.5281/ZENODO.12159343</a>.","ama":"Garcia Castillo DF, Barton NH, Faria R, et al. Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails. 2024. doi:<a href=\"https://doi.org/10.5281/ZENODO.12159343\">10.5281/ZENODO.12159343</a>","short":"D.F. Garcia Castillo, N.H. Barton, R. Faria, J. Larsson, S. Stankowski, R. Butlin, K. Johannesson, A.M. Westram, (2024).","ieee":"D. F. Garcia Castillo <i>et al.</i>, “Data and code for: Predicting rapid adaptation in time from adaptation in space: a 30-year field experiment in marine snails.” Zenodo, 2024."},"oa":1,"OA_place":"repository","publisher":"Zenodo","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5281/zenodo.12159344"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"19"},{"OA_place":"publisher","oa":1,"publication_status":"published","publisher":"Institute of Science and Technology Austria","file_date_updated":"2024-01-03T18:31:34Z","page":"183","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","corr_author":"1","type":"dissertation","year":"2024","project":[{"call_identifier":"H2020","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"name":"Causes and consequences of population fragmentation","grant_number":"P32896","_id":"c08d3278-5a5b-11eb-8a69-fdb09b55f4b8"},{"grant_number":"26380","_id":"34c872fe-11ca-11ed-8bc3-8534b82131e6","name":"Polygenic Adaptation in a Metapopulation"}],"department":[{"_id":"NiBa"},{"_id":"GradSch"}],"license":"https://creativecommons.org/licenses/by-nc-sa/4.0/","supplementarymaterial":"yes","ec_funded":1,"_id":"14711","date_published":"2024-01-19T00:00:00Z","author":[{"full_name":"Olusanya, Oluwafunmilola O","id":"41AD96DC-F248-11E8-B48F-1D18A9856A87","first_name":"Oluwafunmilola O","last_name":"Olusanya","orcid":"0000-0003-1971-8314"}],"file":[{"date_created":"2024-01-03T18:30:13Z","file_size":16986244,"date_updated":"2024-01-03T18:30:13Z","file_id":"14730","file_name":"FinalSubmission_Thesis_OLUSANYA.zip","creator":"oolusany","checksum":"de179b1c6758f182ff0c70d8b38c1501","relation":"source_file","access_level":"closed","content_type":"application/zip"},{"access_level":"open_access","content_type":"application/pdf","creator":"oolusany","file_name":"FinalSubmission2_Thesis_OLUSANYA.pdf","relation":"main_file","checksum":"0e331585e3cd4823320aab4e69e64ccf","date_updated":"2024-01-03T18:31:34Z","file_id":"14731","success":1,"file_size":6460403,"date_created":"2024-01-03T18:31:34Z"}],"researchdata_availability":"no","date_updated":"2026-10-21T08:24:47Z","month":"01","article_processing_charge":"No","title":"Local adaptation, genetic load and extinction in metapopulations","date_created":"2023-12-26T22:49:53Z","supervisor":[{"orcid":"0000-0002-8548-5240","last_name":"Barton","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"},{"last_name":"Polechova","first_name":"Jitka","full_name":"Polechova, Jitka"},{"full_name":"Sachdeva, Himani","first_name":"Himani","last_name":"Sachdeva"}],"citation":{"apa":"Olusanya, O. O. (2024). <i>Local adaptation, genetic load and extinction in metapopulations</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/at:ista:14711\">https://doi.org/10.15479/at:ista:14711</a>","ista":"Olusanya OO. 2024. Local adaptation, genetic load and extinction in metapopulations. Institute of Science and Technology Austria.","mla":"Olusanya, Oluwafunmilola O. <i>Local Adaptation, Genetic Load and Extinction in Metapopulations</i>. Institute of Science and Technology Austria, 2024, doi:<a href=\"https://doi.org/10.15479/at:ista:14711\">10.15479/at:ista:14711</a>.","ieee":"O. O. Olusanya, “Local adaptation, genetic load and extinction in metapopulations,” Institute of Science and Technology Austria, 2024.","short":"O.O. Olusanya, Local Adaptation, Genetic Load and Extinction in Metapopulations, Institute of Science and Technology Austria, 2024.","ama":"Olusanya OO. Local adaptation, genetic load and extinction in metapopulations. 2024. doi:<a href=\"https://doi.org/10.15479/at:ista:14711\">10.15479/at:ista:14711</a>","chicago":"Olusanya, Oluwafunmilola O. “Local Adaptation, Genetic Load and Extinction in Metapopulations.” Institute of Science and Technology Austria, 2024. <a href=\"https://doi.org/10.15479/at:ista:14711\">https://doi.org/10.15479/at:ista:14711</a>."},"oa_version":"Published Version","day":"19","tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode"},"status":"public","has_accepted_license":"1","degree_awarded":"PhD","doi_confirm":"1","abstract":[{"text":"In nature, different species find their niche in a range of environments, each with its unique characteristics. While some thrive in uniform (homogeneous) landscapes where environmental conditions stay relatively consistent across space, others traverse the complexities of spatially heterogeneous terrains. Comprehending how species are distributed and how they interact within these landscapes holds the key to gaining insights into their evolutionary dynamics while also informing conservation and management strategies.\r\n\r\nFor species inhabiting heterogeneous landscapes, when the rate of dispersal is low compared to spatial fluctuations in selection pressure, localized adaptations may emerge. Such adaptation in response to varying selection strengths plays an important role in the persistence of populations in our rapidly changing world. Hence, species in nature are continuously in a struggle to adapt to local environmental conditions, to ensure their continued survival. Natural populations can often adapt in time scales short enough for evolutionary changes to influence ecological dynamics and vice versa, thereby creating a feedback between evolution and demography. The analysis of this feedback and the relative contributions of gene flow, demography, drift, and natural selection to genetic variation and differentiation has remained a recurring theme in evolutionary biology. Nevertheless, the effective role of these forces in maintaining variation and shaping patterns of diversity is not fully understood. Even in homogeneous environments devoid of local adaptations, such understanding remains elusive. Understanding this feedback is crucial, for example in determining the conditions under which extinction risk can be mitigated in peripheral populations subject to deleterious mutation accumulation at the edges of species’ ranges\r\nas well as in highly fragmented populations.\r\n\r\nIn this thesis we explore both uniform and spatially heterogeneous metapopulations, investigating and providing theoretical insights into the dynamics of local adaptation in the latter and examining the dynamics of load and extinction as well as the impact of joint ecological and evolutionary (eco-evolutionary) dynamics in the former. The thesis is divided into 5 chapters.\r\n\r\nChapter 1 provides a general introduction into the subject matter, clarifying concepts and ideas used throughout the thesis. In chapter 2, we explore how fast a species distributed across a heterogeneous landscape adapts to changing conditions marked by alterations in carrying capacity, selection pressure, and migration rate.\r\n\r\nIn chapter 3, we investigate how migration selection and drift influences adaptation and the maintenance of variation in a metapopulation with three habitats, an extension of previous models of adaptation in two habitats. We further develop analytical approximations for the critical threshold required for polymorphism to persist.\r\n\r\nThe focus of chapter 4 of the thesis is on understanding the interplay between ecology and evolution as coupled processes. We investigate how eco-evolutionary feedback between migration, selection, drift, and demography influences eco-evolutionary outcomes in marginal populations subject to deleterious mutation accumulation. Using simulations as well as theoretical approximations of the coupled dynamics of population size and allele frequency, we analyze how gene flow from a large mainland source influences genetic load and population size on an island (i.e., in a marginal population) under genetically realistic assumptions. Analyses of this sort are important because small isolated populations, are repeatedly affected by complex interactions between ecological and evolutionary processes, which can lead to their death. Understanding these interactions can therefore provide an insight into the conditions under which extinction risk can be mitigated in peripheral populations thus, contributing to conservation and restoration efforts.\r\n\r\nChapter 5 extends the analysis in chapter 4 to consider the dynamics of load (due to deleterious mutation accumulation) and extinction risk in a metapopulation. We explore the role of gene flow, selection, and dominance on load and extinction risk and further pinpoint critical thresholds required for metapopulation persistence.\r\n\r\nOverall this research contributes to our understanding of ecological and evolutionary mechanisms that shape species’ persistence in fragmented landscapes, a crucial foundation for successful conservation efforts and biodiversity management.","lang":"eng"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2663-337X"]},"doi":"10.15479/at:ista:14711","ddc":["576"],"acknowledged_ssus":[{"_id":"SSU"}],"das_tickbox":"0","related_material":{"record":[{"id":"10787","relation":"part_of_dissertation","status":"public"},{"status":"public","relation":"part_of_dissertation","id":"10658"},{"status":"public","id":"14732","relation":"part_of_dissertation"}]},"alternative_title":["ISTA Thesis"],"fulldoi":"https://doi.org/10.15479/at:ista:14711"},{"day":"10","DOAJ_listed":"1","external_id":{"pmid":["38857283"],"isi":["001246176800003"]},"oa_version":"Published Version","citation":{"ista":"Burnett L, Koppensteiner P, Symonova O, Masson T, Vega Zuniga TA, Contreras X, Rülicke T, Shigemoto R, Novarino G, Jösch MA. 2024. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. PLoS Biology. 22, e3002668.","apa":"Burnett, L., Koppensteiner, P., Symonova, O., Masson, T., Vega Zuniga, T. A., Contreras, X., … Jösch, M. A. (2024). Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. <i>PLoS Biology</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pbio.3002668\">https://doi.org/10.1371/journal.pbio.3002668</a>","ieee":"L. Burnett <i>et al.</i>, “Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice,” <i>PLoS Biology</i>, vol. 22. Public Library of Science, 2024.","chicago":"Burnett, Laura, Peter Koppensteiner, Olga Symonova, Tomas Masson, Tomas A Vega Zuniga, Ximena Contreras, Thomas Rülicke, Ryuichi Shigemoto, Gaia Novarino, and Maximilian A Jösch. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” <i>PLoS Biology</i>. Public Library of Science, 2024. <a href=\"https://doi.org/10.1371/journal.pbio.3002668\">https://doi.org/10.1371/journal.pbio.3002668</a>.","short":"L. Burnett, P. Koppensteiner, O. Symonova, T. Masson, T.A. Vega Zuniga, X. Contreras, T. Rülicke, R. Shigemoto, G. Novarino, M.A. Jösch, PLoS Biology 22 (2024).","ama":"Burnett L, Koppensteiner P, Symonova O, et al. Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice. <i>PLoS Biology</i>. 2024;22. doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002668\">10.1371/journal.pbio.3002668</a>","mla":"Burnett, Laura, et al. “Shared Behavioural Impairments in Visual Perception and Place Avoidance across Different Autism Models Are Driven by Periaqueductal Grey Hypoexcitability in Setd5 Haploinsufficient Mice.” <i>PLoS Biology</i>, vol. 22, e3002668, Public Library of Science, 2024, doi:<a href=\"https://doi.org/10.1371/journal.pbio.3002668\">10.1371/journal.pbio.3002668</a>."},"status":"public","has_accepted_license":"1","tmp":{"image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1371/journal.pbio.3002668","publication_identifier":{"issn":["1544-9173"],"eissn":["1545-7885"]},"language":[{"iso":"eng"}],"isi":1,"abstract":[{"text":"Despite the diverse genetic origins of autism spectrum disorders (ASDs), affected individuals share strikingly similar and correlated behavioural traits that include perceptual and sensory processing challenges. Notably, the severity of these sensory symptoms is often predictive of the expression of other autistic traits. However, the origin of these perceptual deficits remains largely elusive. Here, we show a recurrent impairment in visual threat perception that is similarly impaired in 3 independent mouse models of ASD with different molecular aetiologies. Interestingly, this deficit is associated with reduced avoidance of threatening environments—a nonperceptual trait. Focusing on a common cause of ASDs, the Setd5 gene mutation, we define the molecular mechanism. We show that the perceptual impairment is caused by a potassium channel (Kv1)-mediated hypoexcitability in a subcortical node essential for the initiation of escape responses, the dorsal periaqueductal grey (dPAG). Targeted pharmacological Kv1 blockade rescued both perceptual and place avoidance deficits, causally linking seemingly unrelated trait deficits to the dPAG. Furthermore, we show that different molecular mechanisms converge on similar behavioural phenotypes by demonstrating that the autism models Cul3 and Ptchd1, despite having similar behavioural phenotypes, differ in their functional and molecular alteration. Our findings reveal a link between rapid perception controlled by subcortical pathways and appropriate learned interactions with the environment and define a nondevelopmental source of such deficits in ASD.","lang":"eng"}],"fulldoi":"https://doi.org/10.1371/journal.pbio.3002668","related_material":{"link":[{"relation":"software","url":"https://doi.org/10.5281/zenodo.11130587"}],"record":[{"status":"public","relation":"research_data","id":"15385"}]},"intvolume":"        22","acknowledgement":"This work was supported by a European Research Council Starting Grant 756502 (MJ). ","das_tickbox":"1","volume":22,"ddc":["570"],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","dataavailabilitystatement":"The mass spectrometry proteomics data have been deposited at the ProteomeXchange Consortium via the PRIDE partner repository with the data set identifier PXD051022. The data used in the analysis can be found in the ISTA data repository DOI: 10.15479/AT:ISTA:15385. The code used to generate the results is available at: https://zenodo.org/records/11130588.","file_date_updated":"2025-01-09T10:39:41Z","publisher":"Public Library of Science","publication_status":"published","oa":1,"quality_controlled":"1","article_number":"e3002668","OA_place":"publisher","pmid":1,"OA_type":"gold","department":[{"_id":"RySh"},{"_id":"GaNo"},{"_id":"MaJö"}],"project":[{"call_identifier":"H2020","name":"Circuits of Visual Attention","_id":"2634E9D2-B435-11E9-9278-68D0E5697425","grant_number":"756502"}],"year":"2024","type":"journal_article","scopus_import":"1","corr_author":"1","APC_amount":"6081,83 EUR","file":[{"relation":"main_file","checksum":"496e1aa4fd5b92b7e4087ecc2c964133","file_name":"2024_PloS_Burnett.pdf","creator":"dernst","content_type":"application/pdf","access_level":"open_access","file_size":4016568,"date_created":"2025-01-09T10:39:41Z","success":1,"file_id":"18805","date_updated":"2025-01-09T10:39:41Z"}],"publication":"PLoS Biology","author":[{"first_name":"Laura","last_name":"Burnett","orcid":"0000-0002-8937-410X","full_name":"Burnett, Laura","id":"3B717F68-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Peter","orcid":"0000-0002-3509-1948","last_name":"Koppensteiner","full_name":"Koppensteiner, Peter","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Olga","last_name":"Symonova","orcid":"0000-0003-2012-9947","full_name":"Symonova, Olga","id":"3C0C7BC6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Tomas","orcid":"0000-0002-2634-6283","last_name":"Masson","full_name":"Masson, Tomas","id":"93ac43e8-8599-11eb-9b86-f6efb0a4c207"},{"last_name":"Vega Zuniga","first_name":"Tomas A","id":"2E7C4E78-F248-11E8-B48F-1D18A9856A87","full_name":"Vega Zuniga, Tomas A"},{"first_name":"Ximena","last_name":"Contreras","full_name":"Contreras, Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Thomas","last_name":"Rülicke","full_name":"Rülicke, Thomas"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444"},{"orcid":"0000-0002-7673-7178","last_name":"Novarino","first_name":"Gaia","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia"},{"id":"2BD278E6-F248-11E8-B48F-1D18A9856A87","full_name":"Jösch, Maximilian A","orcid":"0000-0002-3937-1330","last_name":"Jösch","first_name":"Maximilian A"}],"date_published":"2024-06-10T00:00:00Z","_id":"17142","ec_funded":1,"supplementarymaterial":"yes","date_created":"2024-06-16T22:01:05Z","article_type":"original","title":"Shared behavioural impairments in visual perception and place avoidance across different autism models are driven by periaqueductal grey hypoexcitability in Setd5 haploinsufficient mice","article_processing_charge":"Yes","researchdata_availability":"yes","month":"06","date_updated":"2026-10-21T08:31:42Z"}]