[{"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"volume":570,"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986928","open_access":"1"}],"abstract":[{"text":"Adult intestinal stem cells are located at the bottom of crypts of Lieberkühn, where they express markers such as LGR5 1,2 and fuel the constant replenishment of the intestinal epithelium1. Although fetal LGR5-expressing cells can give rise to adult intestinal stem cells3,4, it remains unclear whether this population in the patterned epithelium represents unique intestinal stem-cell precursors. Here we show, using unbiased quantitative lineage-tracing approaches, biophysical modelling and intestinal transplantation, that all cells of the mouse intestinal epithelium—irrespective of their location and pattern of LGR5 expression in the fetal gut tube—contribute actively to the adult intestinal stem cell pool. Using 3D imaging, we find that during fetal development the villus undergoes gross remodelling and fission. This brings epithelial cells from the non-proliferative villus into the proliferative intervillus region, which enables them to contribute to the adult stem-cell niche. Our results demonstrate that large-scale remodelling of the intestinal wall and cell-fate specification are closely linked. Moreover, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissues following damage5,6,7,8,9, revealing that stem-cell identity is an induced rather than a hardwired property.","lang":"eng"}],"oa":1,"publisher":"Springer Nature","date_created":"2019-06-02T21:59:14Z","status":"public","department":[{"_id":"EdHa"}],"language":[{"iso":"eng"}],"year":"2019","author":[{"full_name":"Guiu, Jordi","first_name":"Jordi","last_name":"Guiu"},{"full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","first_name":"Edouard B","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Yui","first_name":"Shiro","full_name":"Yui, Shiro"},{"first_name":"Samuel","last_name":"Demharter","full_name":"Demharter, Samuel"},{"last_name":"Ulyanchenko","first_name":"Svetlana","full_name":"Ulyanchenko, Svetlana"},{"first_name":"Martti","last_name":"Maimets","full_name":"Maimets, Martti"},{"last_name":"Jørgensen","first_name":"Anne","full_name":"Jørgensen, Anne"},{"first_name":"Signe","last_name":"Perlman","full_name":"Perlman, Signe"},{"last_name":"Lundvall","first_name":"Lene","full_name":"Lundvall, Lene"},{"last_name":"Mamsen","first_name":"Linn Salto","full_name":"Mamsen, Linn Salto"},{"full_name":"Larsen, Agnete","first_name":"Agnete","last_name":"Larsen"},{"first_name":"Rasmus H.","last_name":"Olesen","full_name":"Olesen, Rasmus H."},{"first_name":"Claus Yding","last_name":"Andersen","full_name":"Andersen, Claus Yding"},{"first_name":"Lea Langhoff","last_name":"Thuesen","full_name":"Thuesen, Lea Langhoff"},{"first_name":"Kristine Juul","last_name":"Hare","full_name":"Hare, Kristine Juul"},{"full_name":"Pers, Tune H.","first_name":"Tune H.","last_name":"Pers"},{"full_name":"Khodosevich, Konstantin","last_name":"Khodosevich","first_name":"Konstantin"},{"first_name":"Benjamin D.","last_name":"Simons","full_name":"Simons, Benjamin D."},{"full_name":"Jensen, Kim B.","last_name":"Jensen","first_name":"Kim B."}],"publication_status":"published","date_updated":"2025-07-10T11:53:29Z","_id":"6513","quality_controlled":"1","month":"06","intvolume":"       570","date_published":"2019-06-06T00:00:00Z","article_processing_charge":"No","doi":"10.1038/s41586-019-1212-5","publication":"Nature","day":"06","external_id":{"isi":["000470149000048"],"pmid":["31092921"]},"isi":1,"citation":{"ista":"Guiu J, Hannezo EB, Yui S, Demharter S, Ulyanchenko S, Maimets M, Jørgensen A, Perlman S, Lundvall L, Mamsen LS, Larsen A, Olesen RH, Andersen CY, Thuesen LL, Hare KJ, Pers TH, Khodosevich K, Simons BD, Jensen KB. 2019. Tracing the origin of adult intestinal stem cells. Nature. 570, 107–111.","chicago":"Guiu, Jordi, Edouard B Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, et al. “Tracing the Origin of Adult Intestinal Stem Cells.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1212-5\">https://doi.org/10.1038/s41586-019-1212-5</a>.","mla":"Guiu, Jordi, et al. “Tracing the Origin of Adult Intestinal Stem Cells.” <i>Nature</i>, vol. 570, Springer Nature, 2019, pp. 107–11, doi:<a href=\"https://doi.org/10.1038/s41586-019-1212-5\">10.1038/s41586-019-1212-5</a>.","ama":"Guiu J, Hannezo EB, Yui S, et al. Tracing the origin of adult intestinal stem cells. <i>Nature</i>. 2019;570:107-111. doi:<a href=\"https://doi.org/10.1038/s41586-019-1212-5\">10.1038/s41586-019-1212-5</a>","apa":"Guiu, J., Hannezo, E. B., Yui, S., Demharter, S., Ulyanchenko, S., Maimets, M., … Jensen, K. B. (2019). Tracing the origin of adult intestinal stem cells. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1212-5\">https://doi.org/10.1038/s41586-019-1212-5</a>","short":"J. Guiu, E.B. Hannezo, S. Yui, S. Demharter, S. Ulyanchenko, M. Maimets, A. Jørgensen, S. Perlman, L. Lundvall, L.S. Mamsen, A. Larsen, R.H. Olesen, C.Y. Andersen, L.L. Thuesen, K.J. Hare, T.H. Pers, K. Khodosevich, B.D. Simons, K.B. Jensen, Nature 570 (2019) 107–111.","ieee":"J. Guiu <i>et al.</i>, “Tracing the origin of adult intestinal stem cells,” <i>Nature</i>, vol. 570. Springer Nature, pp. 107–111, 2019."},"oa_version":"Submitted Version","page":"107-111","pmid":1,"title":"Tracing the origin of adult intestinal stem cells","type":"journal_article","scopus_import":"1"},{"department":[{"_id":"HeEd"}],"author":[{"full_name":"Dyer, Ramsay","last_name":"Dyer","first_name":"Ramsay"},{"full_name":"Vegter, Gert","last_name":"Vegter","first_name":"Gert"},{"orcid":"0000-0002-7472-2220","full_name":"Wintraecken, Mathijs","last_name":"Wintraecken","id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","first_name":"Mathijs"}],"language":[{"iso":"eng"}],"year":"2019","ddc":["510"],"status":"public","date_created":"2019-06-03T09:35:33Z","oa":1,"publisher":"Carleton University","file_date_updated":"2020-07-14T12:47:32Z","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["1920-180X"]},"volume":10,"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"We give non-degeneracy criteria for Riemannian simplices based on simplices in spaces of constant sectional curvature. It extends previous work on Riemannian simplices, where we developed Riemannian simplices with respect to Euclidean reference simplices. The criteria we give in this article are in terms of quality measures for spaces of constant curvature that we develop here. We see that simplices in spaces that have nearly constant curvature, are already non-degenerate under very weak quality demands. This is of importance because it allows for sampling of Riemannian manifolds based on anisotropy of the manifold and not (absolute) curvature.","lang":"eng"}],"issue":"1","oa_version":"Published Version","scopus_import":1,"title":"Simplices modelled on spaces of constant curvature","type":"journal_article","page":"223–256","day":"01","publication":"Journal of Computational Geometry ","citation":{"apa":"Dyer, R., Vegter, G., &#38; Wintraecken, M. (2019). Simplices modelled on spaces of constant curvature. <i>Journal of Computational Geometry </i>. Carleton University. <a href=\"https://doi.org/10.20382/jocg.v10i1a9\">https://doi.org/10.20382/jocg.v10i1a9</a>","short":"R. Dyer, G. Vegter, M. Wintraecken, Journal of Computational Geometry  10 (2019) 223–256.","ieee":"R. Dyer, G. Vegter, and M. Wintraecken, “Simplices modelled on spaces of constant curvature,” <i>Journal of Computational Geometry </i>, vol. 10, no. 1. Carleton University, pp. 223–256, 2019.","chicago":"Dyer, Ramsay, Gert Vegter, and Mathijs Wintraecken. “Simplices Modelled on Spaces of Constant Curvature.” <i>Journal of Computational Geometry </i>. Carleton University, 2019. <a href=\"https://doi.org/10.20382/jocg.v10i1a9\">https://doi.org/10.20382/jocg.v10i1a9</a>.","ama":"Dyer R, Vegter G, Wintraecken M. Simplices modelled on spaces of constant curvature. <i>Journal of Computational Geometry </i>. 2019;10(1):223–256. doi:<a href=\"https://doi.org/10.20382/jocg.v10i1a9\">10.20382/jocg.v10i1a9</a>","mla":"Dyer, Ramsay, et al. “Simplices Modelled on Spaces of Constant Curvature.” <i>Journal of Computational Geometry </i>, vol. 10, no. 1, Carleton University, 2019, pp. 223–256, doi:<a href=\"https://doi.org/10.20382/jocg.v10i1a9\">10.20382/jocg.v10i1a9</a>.","ista":"Dyer R, Vegter G, Wintraecken M. 2019. Simplices modelled on spaces of constant curvature. Journal of Computational Geometry . 10(1), 223–256."},"file":[{"file_name":"mainJournalFinal.pdf","access_level":"open_access","date_created":"2019-06-03T09:30:01Z","file_size":2170882,"file_id":"6516","relation":"main_file","checksum":"57b4df2f16a74eb499734ec8ee240178","creator":"mwintrae","date_updated":"2020-07-14T12:47:32Z","content_type":"application/pdf"}],"doi":"10.20382/jocg.v10i1a9","license":"https://creativecommons.org/licenses/by/4.0/","month":"07","intvolume":"        10","quality_controlled":"1","_id":"6515","publication_status":"published","date_updated":"2021-01-12T08:07:50Z","date_published":"2019-07-01T00:00:00Z","ec_funded":1},{"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"},{"name":"Microglia action towards neuronal circuit formation and function in health and disease","call_identifier":"H2020","grant_number":"715571","_id":"25D4A630-B435-11E9-9278-68D0E5697425"},{"name":"Modulating microglia through G protein-coupled receptor (GPCR) signaling","_id":"267F75D8-B435-11E9-9278-68D0E5697425"}],"file_date_updated":"2020-07-14T12:47:33Z","publisher":"Elsevier","oa":1,"date_created":"2019-06-05T13:16:24Z","abstract":[{"text":"Microglia have emerged as a critical component of neurodegenerative diseases. Genetic manipulation of microglia can elucidate their functional impact in disease. In neuroscience, recombinant viruses such as lentiviruses and adeno-associated viruses (AAVs) have been successfully used to target various cell types in the brain, although effective transduction of microglia is rare. In this review, we provide a short background of lentiviruses and AAVs, and strategies for designing recombinant viral vectors. Then, we will summarize recent literature on successful microglial transductions in vitro and in vivo, and discuss the current challenges. Finally, we provide guidelines for reporting the efficiency and specificity of viral targeting in microglia, which will enable the microglial research community to assess and improve methodologies for future studies.","lang":"eng"}],"article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","volume":707,"publication_identifier":{"issn":["0304-3940"]},"language":[{"iso":"eng"}],"year":"2019","author":[{"full_name":"Maes, Margaret E","orcid":"0000-0001-9642-1085","first_name":"Margaret E","id":"3838F452-F248-11E8-B48F-1D18A9856A87","last_name":"Maes"},{"last_name":"Colombo","id":"3483CF6C-F248-11E8-B48F-1D18A9856A87","first_name":"Gloria","orcid":"0000-0001-9434-8902","full_name":"Colombo, Gloria"},{"last_name":"Schulz","id":"4C5E7B96-F248-11E8-B48F-1D18A9856A87","first_name":"Rouven","orcid":"0000-0001-5297-733X","full_name":"Schulz, Rouven"},{"first_name":"Sandra","last_name":"Siegert","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","full_name":"Siegert, Sandra","orcid":"0000-0001-8635-0877"}],"department":[{"_id":"SaSi"}],"corr_author":"1","status":"public","ddc":["570"],"article_number":"134310","doi":"10.1016/j.neulet.2019.134310","article_processing_charge":"No","ec_funded":1,"date_published":"2019-08-10T00:00:00Z","date_updated":"2025-03-31T16:01:17Z","publication_status":"published","_id":"6521","quality_controlled":"1","month":"08","intvolume":"       707","title":"Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges","pmid":1,"type":"journal_article","scopus_import":"1","oa_version":"Published Version","file":[{"date_updated":"2020-07-14T12:47:33Z","content_type":"application/pdf","date_created":"2019-06-08T11:44:20Z","access_level":"open_access","file_name":"2019_Neuroscience_Maes.pdf","file_size":1779287,"relation":"main_file","checksum":"553c9dbd39727fbed55ee991c51ca4d1","file_id":"6551","creator":"dernst"}],"isi":1,"citation":{"mla":"Maes, Margaret E., et al. “Targeting Microglia with Lentivirus and AAV: Recent Advances and Remaining Challenges.” <i>Neuroscience Letters</i>, vol. 707, 134310, Elsevier, 2019, doi:<a href=\"https://doi.org/10.1016/j.neulet.2019.134310\">10.1016/j.neulet.2019.134310</a>.","ama":"Maes ME, Colombo G, Schulz R, Siegert S. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. <i>Neuroscience Letters</i>. 2019;707. doi:<a href=\"https://doi.org/10.1016/j.neulet.2019.134310\">10.1016/j.neulet.2019.134310</a>","chicago":"Maes, Margaret E, Gloria Colombo, Rouven Schulz, and Sandra Siegert. “Targeting Microglia with Lentivirus and AAV: Recent Advances and Remaining Challenges.” <i>Neuroscience Letters</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.neulet.2019.134310\">https://doi.org/10.1016/j.neulet.2019.134310</a>.","ista":"Maes ME, Colombo G, Schulz R, Siegert S. 2019. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. Neuroscience Letters. 707, 134310.","ieee":"M. E. Maes, G. Colombo, R. Schulz, and S. Siegert, “Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges,” <i>Neuroscience Letters</i>, vol. 707. Elsevier, 2019.","apa":"Maes, M. E., Colombo, G., Schulz, R., &#38; Siegert, S. (2019). Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. <i>Neuroscience Letters</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neulet.2019.134310\">https://doi.org/10.1016/j.neulet.2019.134310</a>","short":"M.E. Maes, G. Colombo, R. Schulz, S. Siegert, Neuroscience Letters 707 (2019)."},"day":"10","publication":"Neuroscience Letters","external_id":{"pmid":["31158432"],"isi":["000486094600037"]}},{"has_accepted_license":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"project":[{"grant_number":"682815","_id":"258AA5B2-B435-11E9-9278-68D0E5697425","name":"Teaching Old Crypto New Tricks","call_identifier":"H2020"}],"file_date_updated":"2020-07-14T12:47:33Z","date_created":"2019-06-06T14:12:36Z","oa":1,"publisher":"Schloss Dagstuhl - Leibniz-Zentrum für Informatik","main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2018/627"}],"abstract":[{"text":"We construct a verifiable delay function (VDF) by showing how the Rivest-Shamir-Wagner time-lock puzzle can be made publicly verifiable. Concretely, we give a statistically sound public-coin protocol to prove that a tuple (N,x,T,y) satisfies y=x2T (mod N) where the prover doesn’t know the factorization of N and its running time is dominated by solving the puzzle, that is, compute x2T, which is conjectured to require T sequential squarings. To get a VDF we make this protocol non-interactive using the Fiat-Shamir heuristic.The motivation for this work comes from the Chia blockchain design, which uses a VDF as akey ingredient. For typical parameters (T≤2 40, N= 2048), our proofs are of size around 10K B, verification cost around three RSA exponentiations and computing the proof is 8000 times faster than solving the puzzle even without any parallelism.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":124,"publication_identifier":{"isbn":["978-3-95977-095-8"],"issn":["1868-8969"]},"author":[{"first_name":"Krzysztof Z","last_name":"Pietrzak","id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z","orcid":"0000-0002-9139-1654"}],"year":"2019","language":[{"iso":"eng"}],"department":[{"_id":"KrPi"}],"status":"public","conference":{"location":"San Diego, CA, United States","start_date":"2019-01-10","end_date":"2019-01-12","name":"ITCS: Innovations in Theoretical Computer Science"},"alternative_title":["LIPIcs"],"ddc":["000"],"doi":"10.4230/LIPICS.ITCS.2019.60","article_number":"60","article_processing_charge":"No","date_published":"2019-01-10T00:00:00Z","ec_funded":1,"_id":"6528","publication_status":"published","date_updated":"2025-07-10T11:53:29Z","intvolume":"       124","month":"01","quality_controlled":"1","type":"conference","title":"Simple verifiable delay functions","scopus_import":"1","oa_version":"Published Version","file":[{"file_size":558770,"access_level":"open_access","file_name":"2019_LIPIcs_Pietrzak.pdf","date_created":"2019-06-06T14:22:04Z","creator":"dernst","file_id":"6529","checksum":"f0ae1bb161431d9db3dea5ace082bfb5","relation":"main_file","date_updated":"2020-07-14T12:47:33Z","content_type":"application/pdf"}],"citation":{"mla":"Pietrzak, Krzysztof Z. “Simple Verifiable Delay Functions.” <i>10th Innovations in Theoretical Computer Science Conference</i>, vol. 124, 60, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019, doi:<a href=\"https://doi.org/10.4230/LIPICS.ITCS.2019.60\">10.4230/LIPICS.ITCS.2019.60</a>.","ama":"Pietrzak KZ. Simple verifiable delay functions. In: <i>10th Innovations in Theoretical Computer Science Conference</i>. Vol 124. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2019. doi:<a href=\"https://doi.org/10.4230/LIPICS.ITCS.2019.60\">10.4230/LIPICS.ITCS.2019.60</a>","chicago":"Pietrzak, Krzysztof Z. “Simple Verifiable Delay Functions.” In <i>10th Innovations in Theoretical Computer Science Conference</i>, Vol. 124. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019. <a href=\"https://doi.org/10.4230/LIPICS.ITCS.2019.60\">https://doi.org/10.4230/LIPICS.ITCS.2019.60</a>.","ista":"Pietrzak KZ. 2019. Simple verifiable delay functions. 10th Innovations in Theoretical Computer Science Conference. ITCS: Innovations in Theoretical Computer Science, LIPIcs, vol. 124, 60.","ieee":"K. Z. Pietrzak, “Simple verifiable delay functions,” in <i>10th Innovations in Theoretical Computer Science Conference</i>, San Diego, CA, United States, 2019, vol. 124.","short":"K.Z. Pietrzak, in:, 10th Innovations in Theoretical Computer Science Conference, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2019.","apa":"Pietrzak, K. Z. (2019). Simple verifiable delay functions. In <i>10th Innovations in Theoretical Computer Science Conference</i> (Vol. 124). San Diego, CA, United States: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. <a href=\"https://doi.org/10.4230/LIPICS.ITCS.2019.60\">https://doi.org/10.4230/LIPICS.ITCS.2019.60</a>"},"publication":"10th Innovations in Theoretical Computer Science Conference","day":"10"},{"date_published":"2019-06-03T00:00:00Z","month":"06","intvolume":"        29","quality_controlled":"1","_id":"6552","date_updated":"2023-08-28T09:38:00Z","publication_status":"published","doi":"10.1016/j.cub.2019.03.035","article_processing_charge":"No","citation":{"ista":"Cremer S. 2019. Social immunity in insects. Current Biology. 29(11), R458–R463.","mla":"Cremer, Sylvia. “Social Immunity in Insects.” <i>Current Biology</i>, vol. 29, no. 11, Elsevier, 2019, pp. R458–63, doi:<a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">10.1016/j.cub.2019.03.035</a>.","ama":"Cremer S. Social immunity in insects. <i>Current Biology</i>. 2019;29(11):R458-R463. doi:<a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">10.1016/j.cub.2019.03.035</a>","chicago":"Cremer, Sylvia. “Social Immunity in Insects.” <i>Current Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">https://doi.org/10.1016/j.cub.2019.03.035</a>.","ieee":"S. Cremer, “Social immunity in insects,” <i>Current Biology</i>, vol. 29, no. 11. Elsevier, pp. R458–R463, 2019.","apa":"Cremer, S. (2019). Social immunity in insects. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">https://doi.org/10.1016/j.cub.2019.03.035</a>","short":"S. Cremer, Current Biology 29 (2019) R458–R463."},"isi":1,"external_id":{"pmid":["31163158"],"isi":["000470902000023"]},"publication":"Current Biology","day":"03","scopus_import":"1","type":"journal_article","title":"Social immunity in insects","pmid":1,"page":"R458-R463","oa_version":"Published Version","abstract":[{"lang":"eng","text":"When animals become sick, infected cells and an armada of activated immune cells attempt to eliminate the pathogen from the body. Once infectious particles have breached the body's physical barriers of the skin or gut lining, an initially local response quickly escalates into a systemic response, attracting mobile immune cells to the site of infection. These cells complement the initial, unspecific defense with a more specialized, targeted response. This can also provide long-term immune memory and protection against future infection. The cell-autonomous defenses of the infected cells are thus aided by the actions of recruited immune cells. These specialized cells are the most mobile cells in the body, constantly patrolling through the otherwise static tissue to detect incoming pathogens. Such constant immune surveillance means infections are noticed immediately and can be rapidly cleared from the body. Some immune cells also remove infected cells that have succumbed to infection. All this prevents pathogen replication and spread to healthy tissues. Although this may involve the sacrifice of some somatic tissue, this is typically replaced quickly. Particular care is, however, given to the reproductive organs, which should always remain disease free (immune privilege). "}],"main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2019.03.035","open_access":"1"}],"issue":"11","publication_identifier":{"issn":["09609822"]},"volume":29,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_type":"original","date_created":"2019-06-09T21:59:10Z","publisher":"Elsevier","oa":1,"status":"public","author":[{"first_name":"Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"}],"year":"2019","language":[{"iso":"eng"}],"department":[{"_id":"SyCr"}]},{"citation":{"ieee":"Y. Xian, C. Lampert, B. Schiele, and Z. Akata, “Zero-shot learning - A comprehensive evaluation of the good, the bad and the ugly,” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>, vol. 41, no. 9. Institute of Electrical and Electronics Engineers, pp. 2251–2265, 2019.","apa":"Xian, Y., Lampert, C., Schiele, B., &#38; Akata, Z. (2019). Zero-shot learning - A comprehensive evaluation of the good, the bad and the ugly. <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. Institute of Electrical and Electronics Engineers. <a href=\"https://doi.org/10.1109/tpami.2018.2857768\">https://doi.org/10.1109/tpami.2018.2857768</a>","short":"Y. Xian, C. Lampert, B. Schiele, Z. Akata, IEEE Transactions on Pattern Analysis and Machine Intelligence 41 (2019) 2251–2265.","ista":"Xian Y, Lampert C, Schiele B, Akata Z. 2019. Zero-shot learning - A comprehensive evaluation of the good, the bad and the ugly. IEEE Transactions on Pattern Analysis and Machine Intelligence. 41(9), 2251–2265.","ama":"Xian Y, Lampert C, Schiele B, Akata Z. Zero-shot learning - A comprehensive evaluation of the good, the bad and the ugly. <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. 2019;41(9):2251-2265. doi:<a href=\"https://doi.org/10.1109/tpami.2018.2857768\">10.1109/tpami.2018.2857768</a>","mla":"Xian, Yongqin, et al. “Zero-Shot Learning - A Comprehensive Evaluation of the Good, the Bad and the Ugly.” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>, vol. 41, no. 9, Institute of Electrical and Electronics Engineers, 2019, pp. 2251–65, doi:<a href=\"https://doi.org/10.1109/tpami.2018.2857768\">10.1109/tpami.2018.2857768</a>.","chicago":"Xian, Yongqin, Christoph Lampert, Bernt Schiele, and Zeynep Akata. “Zero-Shot Learning - A Comprehensive Evaluation of the Good, the Bad and the Ugly.” <i>IEEE Transactions on Pattern Analysis and Machine Intelligence</i>. Institute of Electrical and Electronics Engineers, 2019. <a href=\"https://doi.org/10.1109/tpami.2018.2857768\">https://doi.org/10.1109/tpami.2018.2857768</a>."},"isi":1,"external_id":{"arxiv":["1707.00600"],"isi":["000480343900015"]},"day":"01","publication":"IEEE Transactions on Pattern Analysis and Machine Intelligence","scopus_import":"1","page":"2251 - 2265","title":"Zero-shot learning - A comprehensive evaluation of the good, the bad and the ugly","type":"journal_article","oa_version":"Preprint","date_published":"2019-09-01T00:00:00Z","quality_controlled":"1","month":"09","intvolume":"        41","date_updated":"2024-12-11T11:49:58Z","publication_status":"published","_id":"6554","doi":"10.1109/tpami.2018.2857768","article_processing_charge":"No","status":"public","year":"2019","language":[{"iso":"eng"}],"author":[{"full_name":"Xian, Yongqin","last_name":"Xian","first_name":"Yongqin"},{"id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","last_name":"Lampert","first_name":"Christoph","orcid":"0000-0002-4561-241X","full_name":"Lampert, Christoph"},{"full_name":"Schiele, Bernt","first_name":"Bernt","last_name":"Schiele"},{"last_name":"Akata","first_name":"Zeynep","full_name":"Akata, Zeynep"}],"department":[{"_id":"ChLa"}],"abstract":[{"lang":"eng","text":"Due to the importance of zero-shot learning, i.e. classifying images where there is a lack of labeled training data, the number of proposed approaches has recently increased steadily. We argue that it is time to take a step back and to analyze the status quo of the area. The purpose of this paper is three-fold. First, given the fact that there is no agreed upon zero-shot learning benchmark, we first define a new benchmark by unifying both the evaluation protocols and data splits of publicly available datasets used for this task. This is an important contribution as published results are often not comparable and sometimes even flawed due to, e.g. pre-training on zero-shot test classes. Moreover, we propose a new zero-shot learning dataset, the Animals with Attributes 2 (AWA2) dataset which we make publicly available both in terms of image features and the images themselves. Second, we compare and analyze a significant number of the state-of-the-art methods in depth, both in the classic zero-shot setting but also in the more realistic generalized zero-shot setting. Finally, we discuss in detail the limitations of the current status of the area which can be taken as a basis for advancing it."}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1707.00600"}],"issue":"9","arxiv":1,"publication_identifier":{"eissn":["1939-3539"],"issn":["0162-8828"]},"volume":41,"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Institute of Electrical and Electronics Engineers","oa":1,"date_created":"2019-06-11T14:05:59Z"},{"article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1089-8638"],"issn":["0022-2836"]},"volume":431,"issue":"17","main_file_link":[{"open_access":"1","url":"http://www.biorxiv.org/content/10.1101/583369v1"}],"abstract":[{"lang":"eng","text":"Optogenetics enables the spatio-temporally precise control of cell and animal behavior. Many optogenetic tools are driven by light-controlled protein–protein interactions (PPIs) that are repurposed from natural light-sensitive domains (LSDs). Applying light-controlled PPIs to new target proteins is challenging because it is difficult to predict which of the many available LSDs, if any, will yield robust light regulation. As a consequence, fusion protein libraries need to be prepared and tested, but methods and platforms to facilitate this process are currently not available. Here, we developed a genetic engineering strategy and vector library for the rapid generation of light-controlled PPIs. The strategy permits fusing a target protein to multiple LSDs efficiently and in two orientations. The public and expandable library contains 29 vectors with blue, green or red light-responsive LSDs, many of which have been previously applied ex vivo and in vivo. We demonstrate the versatility of the approach and the necessity for sampling LSDs by generating light-activated caspase-9 (casp9) enzymes. Collectively, this work provides a new resource for optical regulation of a broad range of target proteins in cell and developmental biology."}],"publisher":"Elsevier","oa":1,"date_created":"2019-06-16T21:59:14Z","status":"public","department":[{"_id":"HaJa"}],"year":"2019","language":[{"iso":"eng"}],"author":[{"first_name":"Alexandra-Madelaine","last_name":"Tichy","id":"29D8BB2C-F248-11E8-B48F-1D18A9856A87","full_name":"Tichy, Alexandra-Madelaine"},{"first_name":"Elliot J.","last_name":"Gerrard","full_name":"Gerrard, Elliot J."},{"first_name":"Julien M.D.","last_name":"Legrand","full_name":"Legrand, Julien M.D."},{"first_name":"Robin M.","last_name":"Hobbs","full_name":"Hobbs, Robin M."},{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","last_name":"Janovjak","first_name":"Harald L","orcid":"0000-0002-8023-9315","full_name":"Janovjak, Harald L"}],"date_updated":"2025-07-10T11:53:33Z","publication_status":"published","_id":"6564","quality_controlled":"1","month":"08","intvolume":"       431","date_published":"2019-08-09T00:00:00Z","article_processing_charge":"No","doi":"10.1016/j.jmb.2019.05.033","publication":"Journal of Molecular Biology","day":"09","external_id":{"isi":["000482872100002"]},"isi":1,"citation":{"ista":"Tichy A-M, Gerrard EJ, Legrand JMD, Hobbs RM, Janovjak HL. 2019. Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. Journal of Molecular Biology. 431(17), 3046–3055.","mla":"Tichy, Alexandra-Madelaine, et al. “Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein–Protein Interactions.” <i>Journal of Molecular Biology</i>, vol. 431, no. 17, Elsevier, 2019, pp. 3046–55, doi:<a href=\"https://doi.org/10.1016/j.jmb.2019.05.033\">10.1016/j.jmb.2019.05.033</a>.","ama":"Tichy A-M, Gerrard EJ, Legrand JMD, Hobbs RM, Janovjak HL. Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. <i>Journal of Molecular Biology</i>. 2019;431(17):3046-3055. doi:<a href=\"https://doi.org/10.1016/j.jmb.2019.05.033\">10.1016/j.jmb.2019.05.033</a>","chicago":"Tichy, Alexandra-Madelaine, Elliot J. Gerrard, Julien M.D. Legrand, Robin M. Hobbs, and Harald L Janovjak. “Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein–Protein Interactions.” <i>Journal of Molecular Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.jmb.2019.05.033\">https://doi.org/10.1016/j.jmb.2019.05.033</a>.","ieee":"A.-M. Tichy, E. J. Gerrard, J. M. D. Legrand, R. M. Hobbs, and H. L. Janovjak, “Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions,” <i>Journal of Molecular Biology</i>, vol. 431, no. 17. Elsevier, pp. 3046–3055, 2019.","short":"A.-M. Tichy, E.J. Gerrard, J.M.D. Legrand, R.M. Hobbs, H.L. Janovjak, Journal of Molecular Biology 431 (2019) 3046–3055.","apa":"Tichy, A.-M., Gerrard, E. J., Legrand, J. M. D., Hobbs, R. M., &#38; Janovjak, H. L. (2019). Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. <i>Journal of Molecular Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.jmb.2019.05.033\">https://doi.org/10.1016/j.jmb.2019.05.033</a>"},"oa_version":"Preprint","page":"3046-3055","type":"journal_article","title":"Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions","scopus_import":"1"},{"department":[{"_id":"ToHe"}],"author":[{"full_name":"Kundu, Atreyee","last_name":"Kundu","first_name":"Atreyee"},{"last_name":"Garcia Soto","id":"4B3207F6-F248-11E8-B48F-1D18A9856A87","first_name":"Miriam","orcid":"0000−0003−2936−5719","full_name":"Garcia Soto, Miriam"},{"last_name":"Prabhakar","first_name":"Pavithra","full_name":"Prabhakar, Pavithra"}],"year":"2019","language":[{"iso":"eng"}],"ddc":["000"],"status":"public","conference":{"name":"ICC: Indian Control Conference","location":"Delhi, India","end_date":"2019-01-11","start_date":"2019-01-09"},"file_date_updated":"2020-10-21T13:13:49Z","date_created":"2019-06-17T06:57:33Z","oa":1,"publisher":"IEEE","has_accepted_license":"1","project":[{"grant_number":"S 11407_N23","_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","call_identifier":"FWF"},{"call_identifier":"FWF","name":"Formal methods for the design and analysis of complex systems","_id":"25F42A32-B435-11E9-9278-68D0E5697425","grant_number":"Z211"}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_identifier":{"isbn":["978-153866246-5"]},"abstract":[{"text":"In this paper, we address the problem of synthesizing periodic switching controllers for stabilizing a family of linear systems. Our broad approach consists of constructing a finite game graph based on the family of linear systems such that every winning strategy on the game graph corresponds to a stabilizing switching controller for the family of linear systems. The construction of a (finite) game graph, the synthesis of a winning strategy and the extraction of a stabilizing controller are all computationally feasible. We illustrate our method on an example.","lang":"eng"}],"oa_version":"Submitted Version","title":"Formal synthesis of stabilizing controllers for periodically controlled linear switched systems","type":"conference","scopus_import":"1","publication":"5th Indian Control Conference Proceedings","day":"16","external_id":{"isi":["000470655700087"]},"isi":1,"file":[{"date_updated":"2020-10-21T13:13:49Z","content_type":"application/pdf","file_size":396031,"access_level":"open_access","file_name":"2019_ICC_Kundu.pdf","date_created":"2020-10-21T13:13:49Z","creator":"dernst","success":1,"file_id":"8687","checksum":"d622a91af1e427f6b1e0ba8e18a2b767","relation":"main_file"}],"citation":{"ista":"Kundu A, Garcia Soto M, Prabhakar P. 2019. Formal synthesis of stabilizing controllers for periodically controlled linear switched systems. 5th Indian Control Conference Proceedings. ICC: Indian Control Conference, 8715598.","ama":"Kundu A, Garcia Soto M, Prabhakar P. Formal synthesis of stabilizing controllers for periodically controlled linear switched systems. In: <i>5th Indian Control Conference Proceedings</i>. IEEE; 2019. doi:<a href=\"https://doi.org/10.1109/INDIANCC.2019.8715598\">10.1109/INDIANCC.2019.8715598</a>","mla":"Kundu, Atreyee, et al. “Formal Synthesis of Stabilizing Controllers for Periodically Controlled Linear Switched Systems.” <i>5th Indian Control Conference Proceedings</i>, 8715598, IEEE, 2019, doi:<a href=\"https://doi.org/10.1109/INDIANCC.2019.8715598\">10.1109/INDIANCC.2019.8715598</a>.","chicago":"Kundu, Atreyee, Miriam Garcia Soto, and Pavithra Prabhakar. “Formal Synthesis of Stabilizing Controllers for Periodically Controlled Linear Switched Systems.” In <i>5th Indian Control Conference Proceedings</i>. IEEE, 2019. <a href=\"https://doi.org/10.1109/INDIANCC.2019.8715598\">https://doi.org/10.1109/INDIANCC.2019.8715598</a>.","ieee":"A. Kundu, M. Garcia Soto, and P. Prabhakar, “Formal synthesis of stabilizing controllers for periodically controlled linear switched systems,” in <i>5th Indian Control Conference Proceedings</i>, Delhi, India, 2019.","short":"A. Kundu, M. Garcia Soto, P. Prabhakar, in:, 5th Indian Control Conference Proceedings, IEEE, 2019.","apa":"Kundu, A., Garcia Soto, M., &#38; Prabhakar, P. (2019). Formal synthesis of stabilizing controllers for periodically controlled linear switched systems. In <i>5th Indian Control Conference Proceedings</i>. Delhi, India: IEEE. <a href=\"https://doi.org/10.1109/INDIANCC.2019.8715598\">https://doi.org/10.1109/INDIANCC.2019.8715598</a>"},"article_processing_charge":"No","doi":"10.1109/INDIANCC.2019.8715598","article_number":"8715598","_id":"6565","publication_status":"published","date_updated":"2025-09-10T10:36:07Z","month":"05","quality_controlled":"1","date_published":"2019-05-16T00:00:00Z"},{"ddc":["540"],"status":"public","department":[{"_id":"MaIb"}],"year":"2019","language":[{"iso":"eng"}],"author":[{"last_name":"Ibáñez","id":"43C61214-F248-11E8-B48F-1D18A9856A87","first_name":"Maria","orcid":"0000-0001-5013-2843","full_name":"Ibáñez, Maria"},{"full_name":"Genç, Aziz","first_name":"Aziz","last_name":"Genç"},{"full_name":"Hasler, Roger","first_name":"Roger","last_name":"Hasler"},{"last_name":"Liu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","first_name":"Yu","orcid":"0000-0001-7313-6740","full_name":"Liu, Yu"},{"full_name":"Dobrozhan, Oleksandr","first_name":"Oleksandr","last_name":"Dobrozhan"},{"full_name":"Nazarenko, Olga","first_name":"Olga","last_name":"Nazarenko"},{"last_name":"Mata","first_name":"María de la","full_name":"Mata, María de la"},{"last_name":"Arbiol","first_name":"Jordi","full_name":"Arbiol, Jordi"},{"first_name":"Andreu","last_name":"Cabot","full_name":"Cabot, Andreu"},{"full_name":"Kovalenko, Maksym V.","first_name":"Maksym V.","last_name":"Kovalenko"}],"volume":13,"publication_identifier":{"issn":["1936-0851"],"eissn":["1936-086X"]},"article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"lang":"eng","text":"Methodologies that involve the use of nanoparticles as “artificial atoms” to rationally build materials in a bottom-up fashion are particularly well-suited to control the matter at the nanoscale. Colloidal synthetic routes allow for an exquisite control over such “artificial atoms” in terms of size, shape, and crystal phase as well as core and surface compositions. We present here a bottom-up approach to produce Pb–Ag–K–S–Te nanocomposites, which is a highly promising system for thermoelectric energy conversion. First, we developed a high-yield and scalable colloidal synthesis route to uniform lead sulfide (PbS) nanorods, whose tips are made of silver sulfide (Ag2S). We then took advantage of the large surface-to-volume ratio to introduce a p-type dopant (K) by replacing native organic ligands with K2Te. Upon thermal consolidation, K2Te-surface modified PbS–Ag2S nanorods yield p-type doped nanocomposites with PbTe and PbS as major phases and Ag2S and Ag2Te as embedded nanoinclusions. Thermoelectric characterization of such consolidated nanosolids showed a high thermoelectric figure-of-merit of 1 at 620 K."}],"issue":"6","publisher":"American Chemical Society","oa":1,"date_created":"2019-06-18T13:54:34Z","file_date_updated":"2020-07-14T12:47:33Z","project":[{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"has_accepted_license":"1","external_id":{"pmid":["31185159"],"isi":["000473248300043"]},"day":"25","publication":"ACS Nano","citation":{"short":"M. Ibáñez, A. Genç, R. Hasler, Y. Liu, O. Dobrozhan, O. Nazarenko, M. de la Mata, J. Arbiol, A. Cabot, M.V. Kovalenko, ACS Nano 13 (2019) 6572–6580.","apa":"Ibáñez, M., Genç, A., Hasler, R., Liu, Y., Dobrozhan, O., Nazarenko, O., … Kovalenko, M. V. (2019). Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. <i>ACS Nano</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acsnano.9b00346\">https://doi.org/10.1021/acsnano.9b00346</a>","ieee":"M. Ibáñez <i>et al.</i>, “Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks,” <i>ACS Nano</i>, vol. 13, no. 6. American Chemical Society, pp. 6572–6580, 2019.","chicago":"Ibáñez, Maria, Aziz Genç, Roger Hasler, Yu Liu, Oleksandr Dobrozhan, Olga Nazarenko, María de la Mata, Jordi Arbiol, Andreu Cabot, and Maksym V. Kovalenko. “Tuning Transport Properties in Thermoelectric Nanocomposites through Inorganic Ligands and Heterostructured Building Blocks.” <i>ACS Nano</i>. American Chemical Society, 2019. <a href=\"https://doi.org/10.1021/acsnano.9b00346\">https://doi.org/10.1021/acsnano.9b00346</a>.","ama":"Ibáñez M, Genç A, Hasler R, et al. Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. <i>ACS Nano</i>. 2019;13(6):6572-6580. doi:<a href=\"https://doi.org/10.1021/acsnano.9b00346\">10.1021/acsnano.9b00346</a>","mla":"Ibáñez, Maria, et al. “Tuning Transport Properties in Thermoelectric Nanocomposites through Inorganic Ligands and Heterostructured Building Blocks.” <i>ACS Nano</i>, vol. 13, no. 6, American Chemical Society, 2019, pp. 6572–80, doi:<a href=\"https://doi.org/10.1021/acsnano.9b00346\">10.1021/acsnano.9b00346</a>.","ista":"Ibáñez M, Genç A, Hasler R, Liu Y, Dobrozhan O, Nazarenko O, Mata M de la, Arbiol J, Cabot A, Kovalenko MV. 2019. Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. ACS Nano. 13(6), 6572–6580."},"file":[{"creator":"dernst","relation":"main_file","file_id":"6644","file_size":8628690,"access_level":"open_access","file_name":"2019_ACSNano_Ibanez.pdf","date_created":"2019-07-16T14:17:09Z","content_type":"application/pdf","date_updated":"2020-07-14T12:47:33Z"}],"isi":1,"oa_version":"Published Version","scopus_import":"1","page":"6572-6580","title":"Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks","type":"journal_article","pmid":1,"quality_controlled":"1","month":"06","intvolume":"        13","keyword":["colloidal nanoparticles","asymmetric nanoparticles","inorganic ligands","heterostructures","catalyst assisted growth","nanocomposites","thermoelectrics"],"date_updated":"2025-04-14T07:44:06Z","publication_status":"published","_id":"6566","ec_funded":1,"date_published":"2019-06-25T00:00:00Z","article_processing_charge":"Yes (in subscription journal)","doi":"10.1021/acsnano.9b00346"},{"OA_type":"gold","article_processing_charge":"No","_id":"6569","date_updated":"2025-05-20T07:48:49Z","publication_status":"published","month":"06","intvolume":"        97","quality_controlled":"1","date_published":"2019-06-13T00:00:00Z","oa_version":"Published Version","type":"conference","title":"Towards understanding knowledge distillation","page":"5142-5151","scopus_import":"1","publication":"Proceedings of the 36th International Conference on Machine Learning","day":"13","file":[{"creator":"bphuong","relation":"main_file","checksum":"a66d00e2694d749250f8507f301320ca","file_id":"6570","file_size":686432,"access_level":"open_access","file_name":"paper.pdf","date_created":"2019-06-20T18:22:56Z","content_type":"application/pdf","date_updated":"2020-07-14T12:47:33Z"}],"citation":{"mla":"Phuong, Mary, and Christoph Lampert. “Towards Understanding Knowledge Distillation.” <i>Proceedings of the 36th International Conference on Machine Learning</i>, vol. 97, ML Research Press, 2019, pp. 5142–51.","ama":"Phuong M, Lampert C. Towards understanding knowledge distillation. In: <i>Proceedings of the 36th International Conference on Machine Learning</i>. Vol 97. ML Research Press; 2019:5142-5151.","chicago":"Phuong, Mary, and Christoph Lampert. “Towards Understanding Knowledge Distillation.” In <i>Proceedings of the 36th International Conference on Machine Learning</i>, 97:5142–51. ML Research Press, 2019.","ista":"Phuong M, Lampert C. 2019. Towards understanding knowledge distillation. Proceedings of the 36th International Conference on Machine Learning. ICML: International Conference on Machine Learning vol. 97, 5142–5151.","ieee":"M. Phuong and C. Lampert, “Towards understanding knowledge distillation,” in <i>Proceedings of the 36th International Conference on Machine Learning</i>, Long Beach, CA, United States, 2019, vol. 97, pp. 5142–5151.","short":"M. Phuong, C. Lampert, in:, Proceedings of the 36th International Conference on Machine Learning, ML Research Press, 2019, pp. 5142–5151.","apa":"Phuong, M., &#38; Lampert, C. (2019). Towards understanding knowledge distillation. In <i>Proceedings of the 36th International Conference on Machine Learning</i> (Vol. 97, pp. 5142–5151). Long Beach, CA, United States: ML Research Press."},"file_date_updated":"2020-07-14T12:47:33Z","date_created":"2019-06-20T18:23:03Z","publisher":"ML Research Press","oa":1,"has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_place":"publisher","volume":97,"abstract":[{"text":"Knowledge distillation, i.e. one classifier being trained on the outputs of another classifier, is an empirically very successful technique for knowledge transfer between classifiers. It has even been observed that classifiers learn much faster and more reliably if trained with the outputs of another classifier as soft labels, instead of from ground truth data. So far, however, there is no satisfactory theoretical explanation of this phenomenon. In this work, we provide the first insights into the working mechanisms of distillation by studying the special case of linear and deep linear classifiers.  Specifically,  we prove a generalization bound that establishes fast convergence of the expected risk of a distillation-trained linear classifier. From the bound and its proof we extract three keyfactors that determine the success of distillation: data geometry – geometric properties of the datadistribution, in particular class separation, has an immediate influence on the convergence speed of the risk; optimization bias– gradient descentoptimization finds a very favorable minimum of the distillation objective; and strong monotonicity– the expected risk of the student classifier always decreases when the size of the training set grows.","lang":"eng"}],"department":[{"_id":"ChLa"}],"corr_author":"1","author":[{"full_name":"Bui Thi Mai, Phuong","id":"3EC6EE64-F248-11E8-B48F-1D18A9856A87","last_name":"Bui Thi Mai","first_name":"Phuong"},{"last_name":"Lampert","id":"40C20FD2-F248-11E8-B48F-1D18A9856A87","first_name":"Christoph","orcid":"0000-0001-8622-7887","full_name":"Lampert, Christoph"}],"year":"2019","language":[{"iso":"eng"}],"ddc":["000"],"conference":{"start_date":"2019-06-10","end_date":"2019-06-15","location":"Long Beach, CA, United States","name":"ICML: International Conference on Machine Learning"},"status":"public"},{"article_processing_charge":"No","doi":"10.1021/jacs.9b01394","publication_status":"published","date_updated":"2025-04-14T07:44:06Z","_id":"6586","quality_controlled":"1","month":"04","intvolume":"       141","ec_funded":1,"date_published":"2019-04-19T00:00:00Z","oa_version":"Published Version","page":"8025-8029","type":"journal_article","pmid":1,"title":"Ligand-mediated band engineering in bottom-up assembled SnTe nanocomposites for thermoelectric energy conversion","scopus_import":"1","day":"19","publication":"Journal of the American Chemical Society","external_id":{"pmid":["31017419 "],"isi":["000469292300004"]},"file":[{"content_type":"application/pdf","date_updated":"2020-07-14T12:47:34Z","creator":"cpetz","file_id":"6587","relation":"main_file","checksum":"34d7ec837869cc6a07996b54f75696b7","file_size":6234004,"date_created":"2019-06-25T11:59:00Z","file_name":"JACS_April2019.pdf","access_level":"open_access"}],"isi":1,"citation":{"apa":"Ibáñez, M., Hasler, R., Genç, A., Liu, Y., Kuster, B., Schuster, M., … Kovalenko, M. V. (2019). Ligand-mediated band engineering in bottom-up assembled SnTe nanocomposites for thermoelectric energy conversion. <i>Journal of the American Chemical Society</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/jacs.9b01394\">https://doi.org/10.1021/jacs.9b01394</a>","short":"M. Ibáñez, R. Hasler, A. Genç, Y. Liu, B. Kuster, M. Schuster, O. Dobrozhan, D. Cadavid, J. Arbiol, A. Cabot, M.V. Kovalenko, Journal of the American Chemical Society 141 (2019) 8025–8029.","ieee":"M. Ibáñez <i>et al.</i>, “Ligand-mediated band engineering in bottom-up assembled SnTe nanocomposites for thermoelectric energy conversion,” <i>Journal of the American Chemical Society</i>, vol. 141, no. 20. American Chemical Society, pp. 8025–8029, 2019.","ista":"Ibáñez M, Hasler R, Genç A, Liu Y, Kuster B, Schuster M, Dobrozhan O, Cadavid D, Arbiol J, Cabot A, Kovalenko MV. 2019. Ligand-mediated band engineering in bottom-up assembled SnTe nanocomposites for thermoelectric energy conversion. Journal of the American Chemical Society. 141(20), 8025–8029.","chicago":"Ibáñez, Maria, Roger Hasler, Aziz Genç, Yu Liu, Beatrice Kuster, Maximilian Schuster, Oleksandr Dobrozhan, et al. “Ligand-Mediated Band Engineering in Bottom-up Assembled SnTe Nanocomposites for Thermoelectric Energy Conversion.” <i>Journal of the American Chemical Society</i>. American Chemical Society, 2019. <a href=\"https://doi.org/10.1021/jacs.9b01394\">https://doi.org/10.1021/jacs.9b01394</a>.","ama":"Ibáñez M, Hasler R, Genç A, et al. Ligand-mediated band engineering in bottom-up assembled SnTe nanocomposites for thermoelectric energy conversion. <i>Journal of the American Chemical Society</i>. 2019;141(20):8025-8029. doi:<a href=\"https://doi.org/10.1021/jacs.9b01394\">10.1021/jacs.9b01394</a>","mla":"Ibáñez, Maria, et al. “Ligand-Mediated Band Engineering in Bottom-up Assembled SnTe Nanocomposites for Thermoelectric Energy Conversion.” <i>Journal of the American Chemical Society</i>, vol. 141, no. 20, American Chemical Society, 2019, pp. 8025–29, doi:<a href=\"https://doi.org/10.1021/jacs.9b01394\">10.1021/jacs.9b01394</a>."},"file_date_updated":"2020-07-14T12:47:34Z","publisher":"American Chemical Society","oa":1,"date_created":"2019-06-25T11:53:35Z","has_accepted_license":"1","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"article_type":"original","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_identifier":{"eissn":["1520-5126"],"issn":["0002-7863"]},"volume":141,"issue":"20","abstract":[{"lang":"eng","text":"The bottom-up assembly of colloidal nanocrystals is a versatile methodology to produce composite nanomaterials with precisely tuned electronic properties. Beyond the synthetic control over crystal domain size, shape, crystal phase, and composition, solution-processed nanocrystals allow exquisite surface engineering. This provides additional means to modulate the nanomaterial characteristics and particularly its electronic transport properties. For instance, inorganic surface ligands can be used to tune the type and concentration of majority carriers or to modify the electronic band structure. Herein, we report the thermoelectric properties of SnTe nanocomposites obtained from the consolidation of surface-engineered SnTe nanocrystals into macroscopic pellets. A CdSe-based ligand is selected to (i) converge the light and heavy bands through partial Cd alloying and (ii) generate CdSe nanoinclusions as a secondary phase within the SnTe matrix, thereby reducing the thermal conductivity. These SnTe-CdSe nanocomposites possess thermoelectric figures of merit of up to 1.3 at 850 K, which is, to the best of our knowledge, the highest thermoelectric figure of merit reported for solution-processed SnTe."}],"department":[{"_id":"MaIb"}],"year":"2019","language":[{"iso":"eng"}],"author":[{"full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843","first_name":"Maria","last_name":"Ibáñez","id":"43C61214-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Roger","last_name":"Hasler","full_name":"Hasler, Roger"},{"full_name":"Genç, Aziz","first_name":"Aziz","last_name":"Genç"},{"full_name":"Liu, Yu","orcid":"0000-0001-7313-6740","first_name":"Yu","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","last_name":"Liu"},{"first_name":"Beatrice","last_name":"Kuster","full_name":"Kuster, Beatrice"},{"full_name":"Schuster, Maximilian","last_name":"Schuster","first_name":"Maximilian"},{"last_name":"Dobrozhan","first_name":"Oleksandr","full_name":"Dobrozhan, Oleksandr"},{"full_name":"Cadavid, Doris","first_name":"Doris","last_name":"Cadavid"},{"last_name":"Arbiol","first_name":"Jordi","full_name":"Arbiol, Jordi"},{"full_name":"Cabot, Andreu","first_name":"Andreu","last_name":"Cabot"},{"last_name":"Kovalenko","first_name":"Maksym V.","full_name":"Kovalenko, Maksym V."}],"ddc":["540"],"status":"public"},{"day":"01","publication":"Results in Mathematics","external_id":{"arxiv":["2101.09068"],"isi":["000473237500002"]},"file":[{"date_created":"2019-07-03T15:20:40Z","access_level":"open_access","file_name":"Springer_2019_Shehu.pdf","file_size":466942,"relation":"main_file","checksum":"c6d18cb1e16fc0c36a0e0f30b4ebbc2d","file_id":"6605","creator":"kschuh","date_updated":"2020-07-14T12:47:34Z","content_type":"application/pdf"}],"isi":1,"citation":{"ieee":"Y. Shehu, “Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces,” <i>Results in Mathematics</i>, vol. 74, no. 4. Springer, 2019.","apa":"Shehu, Y. (2019). Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces. <i>Results in Mathematics</i>. Springer. <a href=\"https://doi.org/10.1007/s00025-019-1061-4\">https://doi.org/10.1007/s00025-019-1061-4</a>","short":"Y. Shehu, Results in Mathematics 74 (2019).","ista":"Shehu Y. 2019. Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces. Results in Mathematics. 74(4), 138.","ama":"Shehu Y. Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces. <i>Results in Mathematics</i>. 2019;74(4). doi:<a href=\"https://doi.org/10.1007/s00025-019-1061-4\">10.1007/s00025-019-1061-4</a>","mla":"Shehu, Yekini. “Convergence Results of Forward-Backward Algorithms for Sum of Monotone Operators in Banach Spaces.” <i>Results in Mathematics</i>, vol. 74, no. 4, 138, Springer, 2019, doi:<a href=\"https://doi.org/10.1007/s00025-019-1061-4\">10.1007/s00025-019-1061-4</a>.","chicago":"Shehu, Yekini. “Convergence Results of Forward-Backward Algorithms for Sum of Monotone Operators in Banach Spaces.” <i>Results in Mathematics</i>. Springer, 2019. <a href=\"https://doi.org/10.1007/s00025-019-1061-4\">https://doi.org/10.1007/s00025-019-1061-4</a>."},"oa_version":"Published Version","title":"Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces","type":"journal_article","scopus_import":"1","publication_status":"published","date_updated":"2024-11-04T13:52:40Z","_id":"6596","quality_controlled":"1","month":"12","intvolume":"        74","ec_funded":1,"date_published":"2019-12-01T00:00:00Z","article_processing_charge":"Yes (via OA deal)","article_number":"138","doi":"10.1007/s00025-019-1061-4","ddc":["000"],"status":"public","department":[{"_id":"VlKo"}],"corr_author":"1","language":[{"iso":"eng"}],"year":"2019","author":[{"full_name":"Shehu, Yekini","orcid":"0000-0001-9224-7139","first_name":"Yekini","last_name":"Shehu","id":"3FC7CB58-F248-11E8-B48F-1D18A9856A87"}],"article_type":"original","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"eissn":["1420-9012"],"issn":["1422-6383"]},"volume":74,"issue":"4","arxiv":1,"abstract":[{"lang":"eng","text":"It is well known that many problems in image recovery, signal processing, and machine learning can be modeled as finding zeros of the sum of maximal monotone and Lipschitz continuous monotone operators. Many papers have studied forward-backward splitting methods for finding zeros of the sum of two monotone operators in Hilbert spaces. Most of the proposed splitting methods in the literature have been proposed for the sum of maximal monotone and inverse-strongly monotone operators in Hilbert spaces. In this paper, we consider splitting methods for finding zeros of the sum of maximal monotone operators and Lipschitz continuous monotone operators in Banach spaces. We obtain weak and strong convergence results for the zeros of the sum of maximal monotone and Lipschitz continuous monotone operators in Banach spaces. Many already studied problems in the literature can be considered as special cases of this paper."}],"file_date_updated":"2020-07-14T12:47:34Z","publisher":"Springer","oa":1,"date_created":"2019-06-29T10:11:30Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","project":[{"name":"Discrete Optimization in Computer Vision: Theory and Practice","call_identifier":"FP7","grant_number":"616160","_id":"25FBA906-B435-11E9-9278-68D0E5697425"},{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}]},{"doi":"10.1016/j.cell.2019.05.052","article_processing_charge":"No","ec_funded":1,"date_published":"2019-07-27T00:00:00Z","publication_status":"published","date_updated":"2025-07-10T11:53:36Z","_id":"6601","quality_controlled":"1","month":"07","intvolume":"       178","page":"12-25","title":"Mechanochemical feedback loops in development and disease","pmid":1,"type":"journal_article","scopus_import":"1","oa_version":"Published Version","isi":1,"citation":{"ama":"Hannezo EB, Heisenberg C-PJ. Mechanochemical feedback loops in development and disease. <i>Cell</i>. 2019;178(1):12-25. doi:<a href=\"https://doi.org/10.1016/j.cell.2019.05.052\">10.1016/j.cell.2019.05.052</a>","mla":"Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Mechanochemical Feedback Loops in Development and Disease.” <i>Cell</i>, vol. 178, no. 1, Elsevier, 2019, pp. 12–25, doi:<a href=\"https://doi.org/10.1016/j.cell.2019.05.052\">10.1016/j.cell.2019.05.052</a>.","chicago":"Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Mechanochemical Feedback Loops in Development and Disease.” <i>Cell</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cell.2019.05.052\">https://doi.org/10.1016/j.cell.2019.05.052</a>.","ista":"Hannezo EB, Heisenberg C-PJ. 2019. Mechanochemical feedback loops in development and disease. Cell. 178(1), 12–25.","ieee":"E. B. Hannezo and C.-P. J. Heisenberg, “Mechanochemical feedback loops in development and disease,” <i>Cell</i>, vol. 178, no. 1. Elsevier, pp. 12–25, 2019.","apa":"Hannezo, E. B., &#38; Heisenberg, C.-P. J. (2019). Mechanochemical feedback loops in development and disease. <i>Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cell.2019.05.052\">https://doi.org/10.1016/j.cell.2019.05.052</a>","short":"E.B. Hannezo, C.-P.J. Heisenberg, Cell 178 (2019) 12–25."},"publication":"Cell","day":"27","external_id":{"isi":["000473002700005"],"pmid":["31251912"]},"project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","call_identifier":"H2020","grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425"},{"_id":"268294B6-B435-11E9-9278-68D0E5697425","grant_number":"P31639","call_identifier":"FWF","name":"Active mechano-chemical description of the cell cytoskeleton"}],"oa":1,"publisher":"Elsevier","date_created":"2019-06-30T21:59:11Z","issue":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cell.2019.05.052"}],"abstract":[{"text":"There is increasing evidence that both mechanical and biochemical signals play important roles in development and disease. The development of complex organisms, in particular, has been proposed to rely on the feedback between mechanical and biochemical patterning events. This feedback occurs at the molecular level via mechanosensation but can also arise as an emergent property of the system at the cellular and tissue level. In recent years, dynamic changes in tissue geometry, flow, rheology, and cell fate specification have emerged as key platforms of mechanochemical feedback loops in multiple processes. Here, we review recent experimental and theoretical advances in understanding how these feedbacks function in development and disease.","lang":"eng"}],"article_type":"review","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0092-8674"]},"volume":178,"language":[{"iso":"eng"}],"year":"2019","author":[{"orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"department":[{"_id":"CaHe"},{"_id":"EdHa"}],"status":"public"},{"file":[{"file_size":2017352,"access_level":"open_access","file_name":"nature_2019_Nguyen.pdf","date_created":"2019-07-08T15:15:28Z","creator":"kschuh","file_id":"6623","checksum":"3283522fffadf4b5fc8c7adfe3ba4564","relation":"main_file","date_updated":"2020-07-14T12:47:34Z","content_type":"application/pdf"}],"isi":1,"citation":{"short":"C.H. Nguyen, T. Glüxam, A. Schlerka, K. Bauer, A.M. Grandits, H. Hackl, O. Dovey, S. Zöchbauer-Müller, J.L. Cooper, G.S. Vassiliou, D. Stoiber, R. Wieser, G. Heller, Scientific Reports 9 (2019).","apa":"Nguyen, C. H., Glüxam, T., Schlerka, A., Bauer, K., Grandits, A. M., Hackl, H., … Heller, G. (2019). SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. <i>Scientific Reports</i>. Nature Publishing Group. <a href=\"https://doi.org/10.1038/s41598-019-45579-0\">https://doi.org/10.1038/s41598-019-45579-0</a>","ieee":"C. H. Nguyen <i>et al.</i>, “SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness,” <i>Scientific Reports</i>, vol. 9, no. 1. Nature Publishing Group, 2019.","chicago":"Nguyen, Chi Huu, Tobias Glüxam, Angela Schlerka, Katharina Bauer, Alexander M. Grandits, Hubert Hackl, Oliver Dovey, et al. “SOCS2 Is Part of a Highly Prognostic 4-Gene Signature in AML and Promotes Disease Aggressiveness.” <i>Scientific Reports</i>. Nature Publishing Group, 2019. <a href=\"https://doi.org/10.1038/s41598-019-45579-0\">https://doi.org/10.1038/s41598-019-45579-0</a>.","mla":"Nguyen, Chi Huu, et al. “SOCS2 Is Part of a Highly Prognostic 4-Gene Signature in AML and Promotes Disease Aggressiveness.” <i>Scientific Reports</i>, vol. 9, no. 1, 9139, Nature Publishing Group, 2019, doi:<a href=\"https://doi.org/10.1038/s41598-019-45579-0\">10.1038/s41598-019-45579-0</a>.","ama":"Nguyen CH, Glüxam T, Schlerka A, et al. SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. <i>Scientific Reports</i>. 2019;9(1). doi:<a href=\"https://doi.org/10.1038/s41598-019-45579-0\">10.1038/s41598-019-45579-0</a>","ista":"Nguyen CH, Glüxam T, Schlerka A, Bauer K, Grandits AM, Hackl H, Dovey O, Zöchbauer-Müller S, Cooper JL, Vassiliou GS, Stoiber D, Wieser R, Heller G. 2019. SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. Scientific Reports. 9(1), 9139."},"publication":"Scientific Reports","day":"24","external_id":{"isi":["000472597400042"]},"title":"SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness","type":"journal_article","scopus_import":"1","oa_version":"Published Version","date_published":"2019-06-24T00:00:00Z","publication_status":"published","date_updated":"2023-08-28T12:26:51Z","_id":"6607","quality_controlled":"1","month":"06","intvolume":"         9","article_number":"9139","doi":"10.1038/s41598-019-45579-0","article_processing_charge":"No","status":"public","ddc":["576"],"year":"2019","language":[{"iso":"eng"}],"author":[{"full_name":"Nguyen, Chi Huu","last_name":"Nguyen","first_name":"Chi Huu"},{"full_name":"Glüxam, Tobias","last_name":"Glüxam","first_name":"Tobias"},{"full_name":"Schlerka, Angela","first_name":"Angela","last_name":"Schlerka"},{"last_name":"Bauer","id":"2ED6B14C-F248-11E8-B48F-1D18A9856A87","first_name":"Katharina","full_name":"Bauer, Katharina"},{"first_name":"Alexander M.","last_name":"Grandits","full_name":"Grandits, Alexander M."},{"full_name":"Hackl, Hubert","first_name":"Hubert","last_name":"Hackl"},{"full_name":"Dovey, Oliver","first_name":"Oliver","last_name":"Dovey"},{"last_name":"Zöchbauer-Müller","first_name":"Sabine","full_name":"Zöchbauer-Müller, Sabine"},{"full_name":"Cooper, Jonathan L.","first_name":"Jonathan L.","last_name":"Cooper"},{"full_name":"Vassiliou, George S.","last_name":"Vassiliou","first_name":"George S."},{"full_name":"Stoiber, Dagmar","last_name":"Stoiber","first_name":"Dagmar"},{"full_name":"Wieser, Rotraud","last_name":"Wieser","first_name":"Rotraud"},{"full_name":"Heller, Gerwin","last_name":"Heller","first_name":"Gerwin"}],"department":[{"_id":"PreCl"}],"issue":"1","abstract":[{"lang":"eng","text":"Acute myeloid leukemia (AML) is a heterogeneous disease with respect to its genetic and molecular basis and to patients´ outcome. Clinical, cytogenetic, and mutational data are used to classify patients into risk groups with different survival, however, within-group heterogeneity is still an issue. Here, we used a robust likelihood-based survival modeling approach and publicly available gene expression data to identify a minimal number of genes whose combined expression values were prognostic of overall survival. The resulting gene expression signature (4-GES) consisted of 4 genes (SOCS2, IL2RA, NPDC1, PHGDH), predicted patient survival as an independent prognostic parameter in several cohorts of AML patients (total, 1272 patients), and further refined prognostication based on the European Leukemia Net classification. An oncogenic role of the top scoring gene in this signature, SOCS2, was investigated using MLL-AF9 and Flt3-ITD/NPM1c driven mouse models of AML. SOCS2 promoted leukemogenesis as well as the abundance, quiescence, and activity of AML stem cells. Overall, the 4-GES represents a highly discriminating prognostic parameter in AML, whose clinical applicability is greatly enhanced by its small number of genes. The newly established role of SOCS2 in leukemia aggressiveness and stemness raises the possibility that the signature might even be exploitable therapeutically."}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","volume":9,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","file_date_updated":"2020-07-14T12:47:34Z","oa":1,"publisher":"Nature Publishing Group","date_created":"2019-07-07T21:59:19Z"},{"oa_version":"Published Version","type":"journal_article","pmid":1,"title":"PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton","scopus_import":"1","day":"07","publication":"Biomolecules","external_id":{"isi":["000475301500018"],"pmid":["31181636"]},"file":[{"date_updated":"2020-07-14T12:47:34Z","content_type":"application/pdf","file_name":"biomolecules-2019-Matous.pdf","date_created":"2019-07-08T15:46:32Z","access_level":"open_access","file_size":1066773,"relation":"main_file","checksum":"1ce1bd36038fe5381057a1bcc6760083","file_id":"6625","creator":"kschuh"}],"isi":1,"citation":{"ista":"Glanc M, Fendrych M, Friml J. 2019. PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton. Biomolecules. 9(6), 222.","chicago":"Glanc, Matous, Matyas Fendrych, and Jiří Friml. “PIN2 Polarity Establishment in Arabidopsis in the Absence of an Intact Cytoskeleton.” <i>Biomolecules</i>. MDPI, 2019. <a href=\"https://doi.org/10.3390/biom9060222\">https://doi.org/10.3390/biom9060222</a>.","ama":"Glanc M, Fendrych M, Friml J. PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton. <i>Biomolecules</i>. 2019;9(6). doi:<a href=\"https://doi.org/10.3390/biom9060222\">10.3390/biom9060222</a>","mla":"Glanc, Matous, et al. “PIN2 Polarity Establishment in Arabidopsis in the Absence of an Intact Cytoskeleton.” <i>Biomolecules</i>, vol. 9, no. 6, 222, MDPI, 2019, doi:<a href=\"https://doi.org/10.3390/biom9060222\">10.3390/biom9060222</a>.","apa":"Glanc, M., Fendrych, M., &#38; Friml, J. (2019). PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton. <i>Biomolecules</i>. MDPI. <a href=\"https://doi.org/10.3390/biom9060222\">https://doi.org/10.3390/biom9060222</a>","short":"M. Glanc, M. Fendrych, J. Friml, Biomolecules 9 (2019).","ieee":"M. Glanc, M. Fendrych, and J. Friml, “PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton,” <i>Biomolecules</i>, vol. 9, no. 6. MDPI, 2019."},"article_processing_charge":"No","article_number":"222","doi":"10.3390/biom9060222","publication_status":"published","date_updated":"2025-04-14T07:45:04Z","_id":"6611","quality_controlled":"1","month":"06","intvolume":"         9","ec_funded":1,"date_published":"2019-06-07T00:00:00Z","department":[{"_id":"JiFr"}],"year":"2019","language":[{"iso":"eng"}],"author":[{"first_name":"Matous","last_name":"Glanc","id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","full_name":"Glanc, Matous","orcid":"0000-0003-0619-7783"},{"full_name":"Fendrych, Matyas","orcid":"0000-0002-9767-8699","first_name":"Matyas","id":"43905548-F248-11E8-B48F-1D18A9856A87","last_name":"Fendrych"},{"first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596"}],"ddc":["580"],"status":"public","file_date_updated":"2020-07-14T12:47:34Z","publisher":"MDPI","oa":1,"date_created":"2019-07-07T21:59:21Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","volume":9,"issue":"6","acknowledged_ssus":[{"_id":"Bio"}],"abstract":[{"lang":"eng","text":"Cell polarity is crucial for the coordinated development of all multicellular organisms. In plants, this is exemplified by the PIN-FORMED (PIN) efflux carriers of the phytohormone auxin: The polar subcellular localization of the PINs is instructive to the directional intercellular auxin transport, and thus to a plethora of auxin-regulated growth and developmental processes. Despite its importance, the regulation of PIN polar subcellular localization remains poorly understood. Here, we have employed advanced live-cell imaging techniques to study the roles of microtubules and actin microfilaments in the establishment of apical polar localization of PIN2 in the epidermis of the Arabidopsis root meristem. We report that apical PIN2 polarity requires neither intact actin microfilaments nor microtubules, suggesting that the primary spatial cue for polar PIN distribution is likely independent of cytoskeleton-guided endomembrane trafficking."}]},{"oa_version":"Published Version","scopus_import":"1","type":"journal_article","title":"The choice of representative volumes in the approximation of effective properties of random materials","page":"635–726","external_id":{"isi":["000482386000006"],"arxiv":["1807.00834"]},"publication":"Archive for Rational Mechanics and Analysis","day":"01","citation":{"ieee":"J. L. Fischer, “The choice of representative volumes in the approximation of effective properties of random materials,” <i>Archive for Rational Mechanics and Analysis</i>, vol. 234, no. 2. Springer, pp. 635–726, 2019.","short":"J.L. Fischer, Archive for Rational Mechanics and Analysis 234 (2019) 635–726.","apa":"Fischer, J. L. (2019). The choice of representative volumes in the approximation of effective properties of random materials. <i>Archive for Rational Mechanics and Analysis</i>. Springer. <a href=\"https://doi.org/10.1007/s00205-019-01400-w\">https://doi.org/10.1007/s00205-019-01400-w</a>","ista":"Fischer JL. 2019. The choice of representative volumes in the approximation of effective properties of random materials. Archive for Rational Mechanics and Analysis. 234(2), 635–726.","mla":"Fischer, Julian L. “The Choice of Representative Volumes in the Approximation of Effective Properties of Random Materials.” <i>Archive for Rational Mechanics and Analysis</i>, vol. 234, no. 2, Springer, 2019, pp. 635–726, doi:<a href=\"https://doi.org/10.1007/s00205-019-01400-w\">10.1007/s00205-019-01400-w</a>.","ama":"Fischer JL. The choice of representative volumes in the approximation of effective properties of random materials. <i>Archive for Rational Mechanics and Analysis</i>. 2019;234(2):635–726. doi:<a href=\"https://doi.org/10.1007/s00205-019-01400-w\">10.1007/s00205-019-01400-w</a>","chicago":"Fischer, Julian L. “The Choice of Representative Volumes in the Approximation of Effective Properties of Random Materials.” <i>Archive for Rational Mechanics and Analysis</i>. Springer, 2019. <a href=\"https://doi.org/10.1007/s00205-019-01400-w\">https://doi.org/10.1007/s00205-019-01400-w</a>."},"isi":1,"file":[{"file_name":"Springer_2019_Fischer.pdf","access_level":"open_access","date_created":"2019-07-08T15:56:47Z","file_size":1377659,"file_id":"6626","checksum":"4cff75fa6addb0770991ad9c474ab404","relation":"main_file","creator":"kschuh","date_updated":"2020-07-14T12:47:34Z","content_type":"application/pdf"}],"article_processing_charge":"Yes (via OA deal)","doi":"10.1007/s00205-019-01400-w","intvolume":"       234","month":"11","quality_controlled":"1","_id":"6617","publication_status":"published","date_updated":"2025-04-15T06:53:15Z","date_published":"2019-11-01T00:00:00Z","corr_author":"1","department":[{"_id":"JuFi"}],"author":[{"full_name":"Fischer, Julian L","orcid":"0000-0002-0479-558X","first_name":"Julian L","last_name":"Fischer","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87"}],"year":"2019","language":[{"iso":"eng"}],"ddc":["500"],"status":"public","date_created":"2019-07-07T21:59:23Z","publisher":"Springer","oa":1,"file_date_updated":"2020-07-14T12:47:34Z","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"has_accepted_license":"1","volume":234,"publication_identifier":{"issn":["0003-9527"],"eissn":["1432-0673"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","article_type":"original","abstract":[{"text":"The effective large-scale properties of materials with random heterogeneities on a small scale are typically determined by the method of representative volumes: a sample of the random material is chosen—the representative volume—and its effective properties are computed by the cell formula. Intuitively, for a fixed sample size it should be possible to increase the accuracy of the method by choosing a material sample which captures the statistical properties of the material particularly well; for example, for a composite material consisting of two constituents, one would select a representative volume in which the volume fraction of the constituents matches closely with their volume fraction in the overall material. Inspired by similar attempts in materials science, Le Bris, Legoll and Minvielle have designed a selection approach for representative volumes which performs remarkably well in numerical examples of linear materials with moderate contrast. In the present work, we provide a rigorous analysis of this selection approach for representative volumes in the context of stochastic homogenization of linear elliptic equations. In particular, we prove that the method essentially never performs worse than a random selection of the material sample and may perform much better if the selection criterion for the material samples is chosen suitably.","lang":"eng"}],"issue":"2","arxiv":1},{"department":[{"_id":"TiBr"}],"year":"2019","language":[{"iso":"eng"}],"author":[{"full_name":"De La Bretèche, Régis","first_name":"Régis","last_name":"De La Bretèche"},{"first_name":"Kevin N","last_name":"Destagnol","id":"44DDECBC-F248-11E8-B48F-1D18A9856A87","full_name":"Destagnol, Kevin N"},{"last_name":"Liu","first_name":"Jianya","full_name":"Liu, Jianya"},{"last_name":"Wu","first_name":"Jie","full_name":"Wu, Jie"},{"full_name":"Zhao, Yongqiang","first_name":"Yongqiang","last_name":"Zhao"}],"status":"public","oa":1,"publisher":"Springer","date_created":"2019-07-07T21:59:25Z","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["1674-7283"]},"volume":62,"arxiv":1,"issue":"12","main_file_link":[{"url":"https://arxiv.org/abs/1709.09476","open_access":"1"}],"abstract":[{"text":"This paper establishes an asymptotic formula with a power-saving error term for the number of rational points of bounded height on the singular cubic surface of ℙ3ℚ given by the following equation 𝑥0(𝑥21+𝑥22)−𝑥33=0 in agreement with the Manin-Peyre conjectures.\r\n","lang":"eng"}],"oa_version":"Preprint","page":"2435–2446","type":"journal_article","title":"On a certain non-split cubic surface","scopus_import":"1","publication":"Science China Mathematics","day":"01","external_id":{"isi":["000509102200001"],"arxiv":["1709.09476"]},"isi":1,"citation":{"ista":"De La Bretèche R, Destagnol KN, Liu J, Wu J, Zhao Y. 2019. On a certain non-split cubic surface. Science China Mathematics. 62(12), 2435–2446.","chicago":"De La Bretèche, Régis, Kevin N Destagnol, Jianya Liu, Jie Wu, and Yongqiang Zhao. “On a Certain Non-Split Cubic Surface.” <i>Science China Mathematics</i>. Springer, 2019. <a href=\"https://doi.org/10.1007/s11425-018-9543-8\">https://doi.org/10.1007/s11425-018-9543-8</a>.","mla":"De La Bretèche, Régis, et al. “On a Certain Non-Split Cubic Surface.” <i>Science China Mathematics</i>, vol. 62, no. 12, Springer, 2019, pp. 2435–2446, doi:<a href=\"https://doi.org/10.1007/s11425-018-9543-8\">10.1007/s11425-018-9543-8</a>.","ama":"De La Bretèche R, Destagnol KN, Liu J, Wu J, Zhao Y. On a certain non-split cubic surface. <i>Science China Mathematics</i>. 2019;62(12):2435–2446. doi:<a href=\"https://doi.org/10.1007/s11425-018-9543-8\">10.1007/s11425-018-9543-8</a>","short":"R. De La Bretèche, K.N. Destagnol, J. Liu, J. Wu, Y. Zhao, Science China Mathematics 62 (2019) 2435–2446.","apa":"De La Bretèche, R., Destagnol, K. N., Liu, J., Wu, J., &#38; Zhao, Y. (2019). On a certain non-split cubic surface. <i>Science China Mathematics</i>. Springer. <a href=\"https://doi.org/10.1007/s11425-018-9543-8\">https://doi.org/10.1007/s11425-018-9543-8</a>","ieee":"R. De La Bretèche, K. N. Destagnol, J. Liu, J. Wu, and Y. Zhao, “On a certain non-split cubic surface,” <i>Science China Mathematics</i>, vol. 62, no. 12. Springer, pp. 2435–2446, 2019."},"article_processing_charge":"No","doi":"10.1007/s11425-018-9543-8","date_updated":"2025-07-10T11:53:39Z","publication_status":"published","_id":"6620","quality_controlled":"1","month":"12","intvolume":"        62","date_published":"2019-12-01T00:00:00Z"},{"volume":116,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"letter_note","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1073/pnas.1905555116"}],"abstract":[{"text":"We read with great interest the recent work in PNAS by Bergero et al. (1) describing differences in male and female recombination patterns on the guppy (Poecilia reticulata) sex chromosome. We fully agree that recombination in males is largely confined to the ends of the sex chromosome. Bergero et al. interpret these results to suggest that our previous findings of population-level variation in the degree of sex chromosome differentiation in this species (2) are incorrect. However, we suggest that their results are entirely consistent with our previous report, and that their interpretation presents a false controversy.","lang":"eng"}],"issue":"26","date_created":"2019-07-07T21:59:25Z","oa":1,"publisher":"National Academy of Sciences","status":"public","department":[{"_id":"BeVi"}],"author":[{"last_name":"Wright","first_name":"Alison E.","full_name":"Wright, Alison E."},{"full_name":"Darolti, Iulia","first_name":"Iulia","last_name":"Darolti"},{"full_name":"Bloch, Natasha I.","first_name":"Natasha I.","last_name":"Bloch"},{"full_name":"Oostra, Vicencio","last_name":"Oostra","first_name":"Vicencio"},{"first_name":"Benjamin A.","last_name":"Sandkam","full_name":"Sandkam, Benjamin A."},{"full_name":"Buechel, Séverine D.","last_name":"Buechel","first_name":"Séverine D."},{"first_name":"Niclas","last_name":"Kolm","full_name":"Kolm, Niclas"},{"first_name":"Felix","last_name":"Breden","full_name":"Breden, Felix"},{"first_name":"Beatriz","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","last_name":"Vicoso","full_name":"Vicoso, Beatriz","orcid":"0000-0002-4579-8306"},{"full_name":"Mank, Judith E.","last_name":"Mank","first_name":"Judith E."}],"language":[{"iso":"eng"}],"year":"2019","intvolume":"       116","month":"06","quality_controlled":"1","_id":"6621","publication_status":"published","date_updated":"2025-05-14T10:56:48Z","date_published":"2019-06-25T00:00:00Z","article_processing_charge":"No","doi":"10.1073/pnas.1905555116","external_id":{"pmid":["31213531"],"isi":["000472719100010"]},"publication":"Proceedings of the National Academy of Sciences of the United States of America","day":"25","citation":{"mla":"Wright, Alison E., et al. “On the Power to Detect Rare Recombination Events.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 26, National Academy of Sciences, 2019, pp. 12607–08, doi:<a href=\"https://doi.org/10.1073/pnas.1905555116\">10.1073/pnas.1905555116</a>.","ama":"Wright AE, Darolti I, Bloch NI, et al. On the power to detect rare recombination events. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2019;116(26):12607-12608. doi:<a href=\"https://doi.org/10.1073/pnas.1905555116\">10.1073/pnas.1905555116</a>","chicago":"Wright, Alison E., Iulia Darolti, Natasha I. Bloch, Vicencio Oostra, Benjamin A. Sandkam, Séverine D. Buechel, Niclas Kolm, Felix Breden, Beatriz Vicoso, and Judith E. Mank. “On the Power to Detect Rare Recombination Events.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2019. <a href=\"https://doi.org/10.1073/pnas.1905555116\">https://doi.org/10.1073/pnas.1905555116</a>.","ista":"Wright AE, Darolti I, Bloch NI, Oostra V, Sandkam BA, Buechel SD, Kolm N, Breden F, Vicoso B, Mank JE. 2019. On the power to detect rare recombination events. Proceedings of the National Academy of Sciences of the United States of America. 116(26), 12607–12608.","ieee":"A. E. Wright <i>et al.</i>, “On the power to detect rare recombination events,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 26. National Academy of Sciences, pp. 12607–12608, 2019.","short":"A.E. Wright, I. Darolti, N.I. Bloch, V. Oostra, B.A. Sandkam, S.D. Buechel, N. Kolm, F. Breden, B. Vicoso, J.E. Mank, Proceedings of the National Academy of Sciences of the United States of America 116 (2019) 12607–12608.","apa":"Wright, A. E., Darolti, I., Bloch, N. I., Oostra, V., Sandkam, B. A., Buechel, S. D., … Mank, J. E. (2019). On the power to detect rare recombination events. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1905555116\">https://doi.org/10.1073/pnas.1905555116</a>"},"isi":1,"oa_version":"Published Version","scopus_import":"1","type":"journal_article","title":"On the power to detect rare recombination events","pmid":1,"page":"12607-12608"},{"date_updated":"2021-01-12T08:08:16Z","publication_status":"published","_id":"6628","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","month":"08","ec_funded":1,"abstract":[{"text":"Fejes Tóth [5] and Schneider [9] studied approximations of smooth convex hypersurfaces in Euclidean space by piecewise  flat  triangular  meshes  with  a  given  number of  vertices  on  the  hypersurface  that  are  optimal  with respect  to  Hausdorff  distance.   They  proved  that  this Hausdorff distance decreases inversely proportional with m 2/(d−1),  where m is  the  number  of  vertices  and d is the  dimension  of  Euclidean  space.   Moreover  the  pro-portionality constant can be expressed in terms of the Gaussian curvature, an intrinsic quantity.  In this short note, we prove the extrinsic nature of this constant for manifolds of sufficiently high codimension.  We do so by constructing an family of isometric embeddings of the flat torus in Euclidean space.","lang":"eng"}],"date_published":"2019-08-01T00:00:00Z","file_date_updated":"2020-07-14T12:47:34Z","oa":1,"date_created":"2019-07-12T08:34:57Z","has_accepted_license":"1","project":[{"call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","grant_number":"754411"}],"publication":"The 31st Canadian Conference in Computational Geometry","ddc":["004"],"day":"01","file":[{"content_type":"application/pdf","date_updated":"2020-07-14T12:47:34Z","relation":"main_file","checksum":"ceabd152cfa55170d57763f9c6c60a53","file_id":"6629","creator":"mwintrae","file_name":"IntrinsicExtrinsicCCCG2019.pdf","date_created":"2019-07-12T08:32:46Z","access_level":"open_access","file_size":321176}],"status":"public","conference":{"location":"Edmonton, Canada","end_date":"2019-08-10","start_date":"2019-08-08","name":"CCCG: Canadian Conference in Computational Geometry"},"citation":{"mla":"Vegter, Gert, and Mathijs Wintraecken. “The Extrinsic Nature of the Hausdorff Distance of Optimal Triangulations of Manifolds.” <i>The 31st Canadian Conference in Computational Geometry</i>, 2019, pp. 275–79.","ama":"Vegter G, Wintraecken M. The extrinsic nature of the Hausdorff distance of optimal triangulations of manifolds. In: <i>The 31st Canadian Conference in Computational Geometry</i>. ; 2019:275-279.","chicago":"Vegter, Gert, and Mathijs Wintraecken. “The Extrinsic Nature of the Hausdorff Distance of Optimal Triangulations of Manifolds.” In <i>The 31st Canadian Conference in Computational Geometry</i>, 275–79, 2019.","ista":"Vegter G, Wintraecken M. 2019. The extrinsic nature of the Hausdorff distance of optimal triangulations of manifolds. The 31st Canadian Conference in Computational Geometry. CCCG: Canadian Conference in Computational Geometry, 275–279.","ieee":"G. Vegter and M. Wintraecken, “The extrinsic nature of the Hausdorff distance of optimal triangulations of manifolds,” in <i>The 31st Canadian Conference in Computational Geometry</i>, Edmonton, Canada, 2019, pp. 275–279.","apa":"Vegter, G., &#38; Wintraecken, M. (2019). The extrinsic nature of the Hausdorff distance of optimal triangulations of manifolds. In <i>The 31st Canadian Conference in Computational Geometry</i> (pp. 275–279). Edmonton, Canada.","short":"G. Vegter, M. Wintraecken, in:, The 31st Canadian Conference in Computational Geometry, 2019, pp. 275–279."},"department":[{"_id":"HeEd"}],"oa_version":"Submitted Version","page":"275-279","year":"2019","language":[{"iso":"eng"}],"author":[{"last_name":"Vegter","first_name":"Gert","full_name":"Vegter, Gert"},{"first_name":"Mathijs","last_name":"Wintraecken","id":"307CFBC8-F248-11E8-B48F-1D18A9856A87","full_name":"Wintraecken, Mathijs","orcid":"0000-0002-7472-2220"}],"type":"conference","title":"The extrinsic nature of the Hausdorff distance of optimal triangulations of manifolds","scopus_import":1},{"scopus_import":"1","author":[{"full_name":"Godard, Benoit G","last_name":"Godard","id":"33280250-F248-11E8-B48F-1D18A9856A87","first_name":"Benoit G"},{"last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J"}],"type":"journal_article","title":"Cell division and tissue mechanics","year":"2019","page":"114-120","language":[{"iso":"eng"}],"oa_version":"None","department":[{"_id":"CaHe"}],"status":"public","citation":{"ista":"Godard BG, Heisenberg C-PJ. 2019. Cell division and tissue mechanics. Current Opinion in Cell Biology. 60, 114–120.","chicago":"Godard, Benoit G, and Carl-Philipp J Heisenberg. “Cell Division and Tissue Mechanics.” <i>Current Opinion in Cell Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.ceb.2019.05.007\">https://doi.org/10.1016/j.ceb.2019.05.007</a>.","ama":"Godard BG, Heisenberg C-PJ. Cell division and tissue mechanics. <i>Current Opinion in Cell Biology</i>. 2019;60:114-120. doi:<a href=\"https://doi.org/10.1016/j.ceb.2019.05.007\">10.1016/j.ceb.2019.05.007</a>","mla":"Godard, Benoit G., and Carl-Philipp J. Heisenberg. “Cell Division and Tissue Mechanics.” <i>Current Opinion in Cell Biology</i>, vol. 60, Elsevier, 2019, pp. 114–20, doi:<a href=\"https://doi.org/10.1016/j.ceb.2019.05.007\">10.1016/j.ceb.2019.05.007</a>.","short":"B.G. Godard, C.-P.J. Heisenberg, Current Opinion in Cell Biology 60 (2019) 114–120.","apa":"Godard, B. G., &#38; Heisenberg, C.-P. J. (2019). Cell division and tissue mechanics. <i>Current Opinion in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ceb.2019.05.007\">https://doi.org/10.1016/j.ceb.2019.05.007</a>","ieee":"B. G. Godard and C.-P. J. Heisenberg, “Cell division and tissue mechanics,” <i>Current Opinion in Cell Biology</i>, vol. 60. Elsevier, pp. 114–120, 2019."},"isi":1,"external_id":{"isi":["000486545800016"]},"day":"01","publication":"Current Opinion in Cell Biology","doi":"10.1016/j.ceb.2019.05.007","date_created":"2019-07-14T21:59:17Z","publisher":"Elsevier","article_processing_charge":"No","date_published":"2019-10-01T00:00:00Z","abstract":[{"text":"The spatiotemporal organization of cell divisions constitutes an integral part in the development of multicellular organisms, and mis-regulation of cell divisions can lead to severe developmental defects. Cell divisions have an important morphogenetic function in development by regulating growth and shape acquisition of developing tissues, and, conversely, tissue morphogenesis is known to affect both the rate and orientation of cell divisions. Moreover, cell divisions are associated with an extensive reorganization of the cytoskeleton and adhesion apparatus in the dividing cells that in turn can affect large-scale tissue rheological properties. Thus, the interplay between cell divisions and tissue morphogenesis plays a key role in embryo and tissue morphogenesis.","lang":"eng"}],"month":"10","intvolume":"        60","quality_controlled":"1","volume":60,"publication_identifier":{"issn":["0955-0674"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6631","publication_status":"published","date_updated":"2023-08-29T06:33:14Z"}]