[{"date_created":"2019-03-10T22:59:19Z","abstract":[{"text":"Pleiotropy is the well-established idea that a single mutation affects multiple phenotypes. If a mutation has opposite effects on fitness when expressed in different contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce the efficacy of selection by limiting the fixation of beneficial mutations through adaptation, and the removal of deleterious mutations through purifying selection. Although this has been widely discussed, in particular in the context of a putative “gender load,” it has yet to be systematically quantified. In this work, we empirically estimate to which extent different pleiotropic regimes impede the efficacy of selection in Drosophila melanogaster. We use whole-genome polymorphism data from a single African population and divergence data from D. simulans to estimate the fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction of selection (DoS). After controlling for confounding covariates, we find that the different pleiotropic regimes have a relatively small, but significant, effect on selection efficacy. Specifically, our results suggest that pleiotropic sexual antagonism may restrict the efficacy of selection, but that this conflict can be resolved by limiting the expression of genes to the sex where they are beneficial. Intermediate levels of pleiotropy across tissues and life stages can also lead to maladaptation in D. melanogaster, due to inefficient purifying selection combined with low frequency of mutations that confer a selective advantage. Thus, our study highlights the need to consider the efficacy of selection in the context of antagonistic pleiotropy, and of genetic conflict in general.","lang":"eng"}],"day":"01","related_material":{"record":[{"status":"public","id":"5757","relation":"popular_science"}]},"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pubmed/30590559"}],"language":[{"iso":"eng"}],"title":"Pleiotropy modulates the efficacy of selection in drosophila melanogaster","volume":36,"pmid":1,"scopus_import":"1","isi":1,"_id":"6089","doi":"10.1093/molbev/msy246","project":[{"name":"Sex chromosome evolution under male- and female- heterogamety","grant_number":"P28842-B22","call_identifier":"FWF","_id":"250ED89C-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","author":[{"id":"32DF5794-F248-11E8-B48F-1D18A9856A87","first_name":"Christelle","full_name":"Fraisse, Christelle","last_name":"Fraisse","orcid":"0000-0001-8441-5075"},{"id":"33AB266C-F248-11E8-B48F-1D18A9856A87","full_name":"Puixeu Sala, Gemma","first_name":"Gemma","last_name":"Puixeu Sala","orcid":"0000-0001-8330-1754"},{"id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz","last_name":"Vicoso","orcid":"0000-0002-4579-8306"}],"page":"500-515","external_id":{"pmid":["30590559"],"isi":["000462585100006"]},"citation":{"ieee":"C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy of selection in drosophila melanogaster,” <i>Molecular biology and evolution</i>, vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.","mla":"Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>, vol. 36, no. 3, Oxford University Press, 2019, pp. 500–15, doi:<a href=\"https://doi.org/10.1093/molbev/msy246\">10.1093/molbev/msy246</a>.","apa":"Fraisse, C., Puixeu Sala, G., &#38; Vicoso, B. (2019). Pleiotropy modulates the efficacy of selection in drosophila melanogaster. <i>Molecular Biology and Evolution</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/molbev/msy246\">https://doi.org/10.1093/molbev/msy246</a>","ama":"Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection in drosophila melanogaster. <i>Molecular biology and evolution</i>. 2019;36(3):500-515. doi:<a href=\"https://doi.org/10.1093/molbev/msy246\">10.1093/molbev/msy246</a>","ista":"Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy of selection in drosophila melanogaster. Molecular biology and evolution. 36(3), 500–515.","chicago":"Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy Modulates the Efficacy of Selection in Drosophila Melanogaster.” <i>Molecular Biology and Evolution</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/molbev/msy246\">https://doi.org/10.1093/molbev/msy246</a>.","short":"C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36 (2019) 500–515."},"intvolume":"        36","publication":"Molecular biology and evolution","type":"journal_article","article_processing_charge":"No","department":[{"_id":"BeVi"},{"_id":"NiBa"}],"oa":1,"publisher":"Oxford University Press","date_updated":"2025-04-15T08:18:38Z","publication_status":"published","date_published":"2019-03-01T00:00:00Z","month":"03","issue":"3","year":"2019","status":"public","oa_version":"Submitted Version","publication_identifier":{"eissn":["1537-1719"],"issn":["0737-4038"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"publisher":"American Physical Society","publication_status":"published","date_updated":"2024-02-28T13:12:06Z","month":"02","date_published":"2019-02-26T00:00:00Z","article_processing_charge":"No","department":[{"_id":"NiBa"},{"_id":"GaTk"}],"article_number":"022423","oa":1,"oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","issue":"2","year":"2019","status":"public","scopus_import":"1","isi":1,"date_created":"2019-03-10T22:59:20Z","day":"26","abstract":[{"lang":"eng","text":"Cells need to reliably sense external ligand concentrations to achieve various biological functions such as chemotaxis or signaling. The molecular recognition of ligands by surface receptors is degenerate in many systems, leading to crosstalk between ligand-receptor pairs. Crosstalk is often thought of as a deviation from optimal specific recognition, as the binding of noncognate ligands can interfere with the detection of the receptor's cognate ligand, possibly leading to a false triggering of a downstream signaling pathway. Here we quantify the optimal precision of sensing the concentrations of multiple ligands by a collection of promiscuous receptors. We demonstrate that crosstalk can improve precision in concentration sensing and discrimination tasks. To achieve superior precision, the additional information about ligand concentrations contained in short binding events of the noncognate ligand should be exploited. We present a proofreading scheme to realize an approximate estimation of multiple ligand concentrations that reaches a precision close to the derived optimal bounds. Our results help rationalize the observed ubiquity of receptor crosstalk in molecular sensing."}],"main_file_link":[{"url":"https://www.biorxiv.org/content/10.1101/448118v1.abstract","open_access":"1"}],"language":[{"iso":"eng"}],"title":"Receptor crosstalk improves concentration sensing of multiple ligands","volume":99,"external_id":{"isi":["000459916500007"]},"citation":{"ista":"Carballo-Pacheco M, Desponds J, Gavrilchenko T, Mayer A, Prizak R, Reddy G, Nemenman I, Mora T. 2019. Receptor crosstalk improves concentration sensing of multiple ligands. Physical Review E. 99(2), 022423.","chicago":"Carballo-Pacheco, Martín, Jonathan Desponds, Tatyana Gavrilchenko, Andreas Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, and Thierry Mora. “Receptor Crosstalk Improves Concentration Sensing of Multiple Ligands.” <i>Physical Review E</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">https://doi.org/10.1103/PhysRevE.99.022423</a>.","short":"M. Carballo-Pacheco, J. Desponds, T. Gavrilchenko, A. Mayer, R. Prizak, G. Reddy, I. Nemenman, T. Mora, Physical Review E 99 (2019).","mla":"Carballo-Pacheco, Martín, et al. “Receptor Crosstalk Improves Concentration Sensing of Multiple Ligands.” <i>Physical Review E</i>, vol. 99, no. 2, 022423, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">10.1103/PhysRevE.99.022423</a>.","ieee":"M. Carballo-Pacheco <i>et al.</i>, “Receptor crosstalk improves concentration sensing of multiple ligands,” <i>Physical Review E</i>, vol. 99, no. 2. American Physical Society, 2019.","apa":"Carballo-Pacheco, M., Desponds, J., Gavrilchenko, T., Mayer, A., Prizak, R., Reddy, G., … Mora, T. (2019). Receptor crosstalk improves concentration sensing of multiple ligands. <i>Physical Review E</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">https://doi.org/10.1103/PhysRevE.99.022423</a>","ama":"Carballo-Pacheco M, Desponds J, Gavrilchenko T, et al. Receptor crosstalk improves concentration sensing of multiple ligands. <i>Physical Review E</i>. 2019;99(2). doi:<a href=\"https://doi.org/10.1103/PhysRevE.99.022423\">10.1103/PhysRevE.99.022423</a>"},"intvolume":"        99","type":"journal_article","publication":"Physical Review E","_id":"6090","doi":"10.1103/PhysRevE.99.022423","quality_controlled":"1","author":[{"first_name":"Martín","full_name":"Carballo-Pacheco, Martín","last_name":"Carballo-Pacheco"},{"last_name":"Desponds","full_name":"Desponds, Jonathan","first_name":"Jonathan"},{"last_name":"Gavrilchenko","full_name":"Gavrilchenko, Tatyana","first_name":"Tatyana"},{"first_name":"Andreas","full_name":"Mayer, Andreas","last_name":"Mayer"},{"first_name":"Roshan","full_name":"Prizak, Roshan","id":"4456104E-F248-11E8-B48F-1D18A9856A87","last_name":"Prizak"},{"last_name":"Reddy","first_name":"Gautam","full_name":"Reddy, Gautam"},{"last_name":"Nemenman","first_name":"Ilya","full_name":"Nemenman, Ilya"},{"full_name":"Mora, Thierry","first_name":"Thierry","last_name":"Mora"}]},{"pmid":1,"isi":1,"scopus_import":"1","abstract":[{"text":"Cortical networks are characterized by sparse connectivity, with synapses found at only a subset of axo-dendritic contacts. Yet within these networks, neurons can exhibit high connection probabilities, suggesting that cell-intrinsic factors, not proximity, determine connectivity. Here, we identify ephrin-B3 (eB3) as a factor that determines synapse density by mediating a cell-cell competition that requires ephrin-B-EphB signaling. In a microisland culture system designed to isolate cell-cell competition, we find that eB3 determines winning and losing neurons in a contest for synapses. In a Mosaic Analysis with Double Markers (MADM) genetic mouse model system in vivo the relative levels of eB3 control spine density in layer 5 and 6 neurons. MADM cortical neurons in vitro reveal that eB3 controls synapse density independently of action potential-driven activity. Our findings illustrate a new class of competitive mechanism mediated by trans-synaptic organizing proteins which control the number of synapses neurons receive relative to neighboring neurons.","lang":"eng"}],"day":"21","date_created":"2019-03-10T22:59:20Z","file_date_updated":"2020-07-14T12:47:19Z","volume":8,"title":"Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs","language":[{"iso":"eng"}],"intvolume":"         8","citation":{"ama":"Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.41563\">10.7554/eLife.41563</a>","apa":"Henderson, N. T., Le Marchand, S. J., Hruska, M., Hippenmeyer, S., Luo, L., &#38; Dalva, M. B. (2019). Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.41563\">https://doi.org/10.7554/eLife.41563</a>","ieee":"N. T. Henderson, S. J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, and M. B. Dalva, “Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","mla":"Henderson, Nathan T., et al. “Ephrin-B3 Controls Excitatory Synapse Density through Cell-Cell Competition for EphBs.” <i>ELife</i>, vol. 8, e41563, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.41563\">10.7554/eLife.41563</a>.","short":"N.T. Henderson, S.J. Le Marchand, M. Hruska, S. Hippenmeyer, L. Luo, M.B. Dalva, ELife 8 (2019).","chicago":"Henderson, Nathan T., Sylvain J. Le Marchand, Martin Hruska, Simon Hippenmeyer, Liqun Luo, and Matthew B. Dalva. “Ephrin-B3 Controls Excitatory Synapse Density through Cell-Cell Competition for EphBs.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.41563\">https://doi.org/10.7554/eLife.41563</a>.","ista":"Henderson NT, Le Marchand SJ, Hruska M, Hippenmeyer S, Luo L, Dalva MB. 2019. Ephrin-B3 controls excitatory synapse density through cell-cell competition for EphBs. eLife. 8, e41563."},"external_id":{"pmid":["30789343"],"isi":["000459380600001"]},"ddc":["570"],"publication":"eLife","type":"journal_article","doi":"10.7554/eLife.41563","_id":"6091","author":[{"last_name":"Henderson","first_name":"Nathan T.","full_name":"Henderson, Nathan T."},{"full_name":"Le Marchand, Sylvain J.","first_name":"Sylvain J.","last_name":"Le Marchand"},{"first_name":"Martin","full_name":"Hruska, Martin","last_name":"Hruska"},{"first_name":"Simon","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer"},{"last_name":"Luo","full_name":"Luo, Liqun","first_name":"Liqun"},{"last_name":"Dalva","full_name":"Dalva, Matthew B.","first_name":"Matthew B."}],"quality_controlled":"1","publisher":"eLife Sciences Publications","date_published":"2019-02-21T00:00:00Z","month":"02","publication_status":"published","date_updated":"2023-08-24T14:50:50Z","department":[{"_id":"SiHi"}],"article_number":"e41563","article_processing_charge":"No","oa":1,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"file":[{"file_id":"6098","relation":"main_file","date_created":"2019-03-11T16:15:37Z","file_name":"2019_eLife_Henderson.pdf","date_updated":"2020-07-14T12:47:19Z","content_type":"application/pdf","access_level":"open_access","checksum":"7b0800d003f14cd06b1802dea0c52941","file_size":7260753,"creator":"dernst"}],"oa_version":"Published Version","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","has_accepted_license":"1","status":"public","year":"2019"},{"issue":"6","year":"2019","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Preprint","oa":1,"department":[{"_id":"MiLe"}],"article_number":"064428","article_processing_charge":"No","publication_status":"published","date_updated":"2025-04-15T07:59:29Z","date_published":"2019-02-01T00:00:00Z","month":"02","publisher":"American Physical Society","author":[{"full_name":"Mentink, Johann H","first_name":"Johann H","last_name":"Mentink"},{"last_name":"Katsnelson","first_name":"Mikhail","full_name":"Katsnelson, Mikhail"},{"id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","first_name":"Mikhail","full_name":"Lemeshko, Mikhail","last_name":"Lemeshko","orcid":"0000-0002-6990-7802"}],"quality_controlled":"1","project":[{"_id":"26031614-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"P29902","name":"Quantum rotations in the presence of a many-body environment"}],"_id":"6092","doi":"10.1103/PhysRevB.99.064428","publication":"Physical Review B","type":"journal_article","intvolume":"        99","arxiv":1,"external_id":{"isi":["000459223400004"],"arxiv":["1802.01638"]},"citation":{"ista":"Mentink JH, Katsnelson M, Lemeshko M. 2019. Quantum many-body dynamics of the Einstein-de Haas effect. Physical Review B. 99(6), 064428.","short":"J.H. Mentink, M. Katsnelson, M. Lemeshko, Physical Review B 99 (2019).","chicago":"Mentink, Johann H, Mikhail Katsnelson, and Mikhail Lemeshko. “Quantum Many-Body Dynamics of the Einstein-de Haas Effect.” <i>Physical Review B</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">https://doi.org/10.1103/PhysRevB.99.064428</a>.","ieee":"J. H. Mentink, M. Katsnelson, and M. Lemeshko, “Quantum many-body dynamics of the Einstein-de Haas effect,” <i>Physical Review B</i>, vol. 99, no. 6. American Physical Society, 2019.","mla":"Mentink, Johann H., et al. “Quantum Many-Body Dynamics of the Einstein-de Haas Effect.” <i>Physical Review B</i>, vol. 99, no. 6, 064428, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">10.1103/PhysRevB.99.064428</a>.","ama":"Mentink JH, Katsnelson M, Lemeshko M. Quantum many-body dynamics of the Einstein-de Haas effect. <i>Physical Review B</i>. 2019;99(6). doi:<a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">10.1103/PhysRevB.99.064428</a>","apa":"Mentink, J. H., Katsnelson, M., &#38; Lemeshko, M. (2019). Quantum many-body dynamics of the Einstein-de Haas effect. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/PhysRevB.99.064428\">https://doi.org/10.1103/PhysRevB.99.064428</a>"},"volume":99,"language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1802.01638"}],"title":"Quantum many-body dynamics of the Einstein-de Haas effect","date_created":"2019-03-10T22:59:20Z","abstract":[{"text":"In 1915, Einstein and de Haas and Barnett demonstrated that changing the magnetization of a magnetic material results in mechanical rotation and vice versa. At the microscopic level, this effect governs the transfer between electron spin and orbital angular momentum, and lattice degrees of freedom, understanding which is key for molecular magnets, nano-magneto-mechanics, spintronics, and ultrafast magnetism. Until now, the timescales of electron-to-lattice angular momentum transfer remain unclear, since modeling this process on a microscopic level requires the addition of an infinite amount of quantum angular momenta. We show that this problem can be solved by reformulating it in terms of the recently discovered angulon quasiparticles, which results in a rotationally invariant quantum many-body theory. In particular, we demonstrate that nonperturbative effects take place even if the electron-phonon coupling is weak and give rise to angular momentum transfer on femtosecond timescales.","lang":"eng"}],"day":"01","isi":1,"scopus_import":"1"},{"file":[{"date_updated":"2020-07-14T12:47:19Z","checksum":"b885de050ed4bb3c86f706487a47197f","access_level":"open_access","content_type":"application/pdf","file_size":2967731,"creator":"dernst","file_id":"6096","relation":"main_file","date_created":"2019-03-11T16:09:23Z","file_name":"2019_PLoSOne_Goudarzi.pdf"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","issue":"2","year":"2019","status":"public","publisher":"Public Library of Science","month":"02","date_published":"2019-02-26T00:00:00Z","publication_status":"published","date_updated":"2023-09-19T14:46:47Z","article_processing_charge":"No","department":[{"_id":"Bio"}],"article_number":"e0212699","oa":1,"citation":{"ista":"Goudarzi M, Boquet-Pujadas A, Olivo-Marin JC, Raz E. 2019. Fluid dynamics during bleb formation in migrating cells in vivo. PLOS ONE. 14(2), e0212699.","chicago":"Goudarzi, Mohammad, Aleix Boquet-Pujadas, Jean Christophe Olivo-Marin, and Erez Raz. “Fluid Dynamics during Bleb Formation in Migrating Cells in Vivo.” <i>PLOS ONE</i>. Public Library of Science, 2019. <a href=\"https://doi.org/10.1371/journal.pone.0212699\">https://doi.org/10.1371/journal.pone.0212699</a>.","short":"M. Goudarzi, A. Boquet-Pujadas, J.C. Olivo-Marin, E. Raz, PLOS ONE 14 (2019).","mla":"Goudarzi, Mohammad, et al. “Fluid Dynamics during Bleb Formation in Migrating Cells in Vivo.” <i>PLOS ONE</i>, vol. 14, no. 2, e0212699, Public Library of Science, 2019, doi:<a href=\"https://doi.org/10.1371/journal.pone.0212699\">10.1371/journal.pone.0212699</a>.","ieee":"M. Goudarzi, A. Boquet-Pujadas, J. C. Olivo-Marin, and E. Raz, “Fluid dynamics during bleb formation in migrating cells in vivo,” <i>PLOS ONE</i>, vol. 14, no. 2. Public Library of Science, 2019.","apa":"Goudarzi, M., Boquet-Pujadas, A., Olivo-Marin, J. C., &#38; Raz, E. (2019). Fluid dynamics during bleb formation in migrating cells in vivo. <i>PLOS ONE</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pone.0212699\">https://doi.org/10.1371/journal.pone.0212699</a>","ama":"Goudarzi M, Boquet-Pujadas A, Olivo-Marin JC, Raz E. Fluid dynamics during bleb formation in migrating cells in vivo. <i>PLOS ONE</i>. 2019;14(2). doi:<a href=\"https://doi.org/10.1371/journal.pone.0212699\">10.1371/journal.pone.0212699</a>"},"external_id":{"isi":["000459712100022"]},"ddc":["570"],"intvolume":"        14","publication":"PLOS ONE","type":"journal_article","doi":"10.1371/journal.pone.0212699","_id":"6093","quality_controlled":"1","author":[{"id":"3384113A-F248-11E8-B48F-1D18A9856A87","first_name":"Mohammad","full_name":"Goudarzi, Mohammad","last_name":"Goudarzi"},{"last_name":"Boquet-Pujadas","first_name":"Aleix","full_name":"Boquet-Pujadas, Aleix"},{"first_name":"Jean Christophe","full_name":"Olivo-Marin, Jean Christophe","last_name":"Olivo-Marin"},{"last_name":"Raz","first_name":"Erez","full_name":"Raz, Erez"}],"scopus_import":"1","isi":1,"day":"26","abstract":[{"text":"Blebs are cellular protrusions observed in migrating cells and in cells undergoing spreading, cytokinesis, and apoptosis. Here we investigate the flow of cytoplasm during bleb formation and the concurrent changes in cell volume using zebrafish primordial germ cells (PGCs) as an in vivo model. We show that bleb inflation occurs concomitantly with cytoplasmic inflow into it and that during this process the total cell volume does not change. We thus show that bleb formation in primordial germ cells results primarily from redistribution of material within the cell rather than being driven by flow of water from an external source.","lang":"eng"}],"date_created":"2019-03-10T22:59:21Z","title":"Fluid dynamics during bleb formation in migrating cells in vivo","language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:19Z","volume":14},{"publisher":"Wiley","date_published":"2019-03-01T00:00:00Z","month":"03","date_updated":"2023-08-24T14:50:27Z","publication_status":"published","article_processing_charge":"No","department":[{"_id":"NiBa"}],"oa":1,"file":[{"access_level":"open_access","file_size":1510715,"checksum":"f915885756057ec0ca5912a41f46a887","content_type":"application/pdf","creator":"dernst","date_updated":"2020-07-14T12:47:19Z","date_created":"2019-03-11T16:12:54Z","file_name":"2019_MolecularEcology_Faria.pdf","relation":"main_file","file_id":"6097"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["1365-294X"],"issn":["0962-1083"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","has_accepted_license":"1","status":"public","issue":"6","year":"2019","scopus_import":"1","isi":1,"abstract":[{"lang":"eng","text":"Both classical and recent studies suggest that chromosomal inversion polymorphisms are important in adaptation and speciation. However, biases in discovery and reporting of inversions make it difficult to assess their prevalence and biological importance. Here, we use an approach based on linkage disequilibrium among markers genotyped for samples collected across a transect between contrasting habitats to detect chromosomal rearrangements de novo. We report 17 polymorphic rearrangements in a single locality for the coastal marine snail, Littorina saxatilis. Patterns of diversity in the field and of recombination in controlled crosses provide strong evidence that at least the majority of these rearrangements are inversions. Most show clinal changes in frequency between habitats, suggestive of divergent selection, but only one appears to be fixed for different arrangements in the two habitats. Consistent with widespread evidence for balancing selection on inversion polymorphisms, we argue that a combination of heterosis and divergent selection can explain the observed patterns and should be considered in other systems spanning environmental gradients."}],"day":"01","date_created":"2019-03-10T22:59:21Z","title":"Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes","related_material":{"record":[{"relation":"research_data","id":"9837","status":"public"}]},"language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:19Z","volume":28,"citation":{"apa":"Faria, R., Chaube, P., Morales, H. E., Larsson, T., Lemmon, A. R., Lemmon, E. M., … Butlin, R. K. (2019). Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>","ama":"Faria R, Chaube P, Morales HE, et al. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. <i>Molecular Ecology</i>. 2019;28(6):1375-1393. doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>","mla":"Faria, Rui, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>, vol. 28, no. 6, Wiley, 2019, pp. 1375–93, doi:<a href=\"https://doi.org/10.1111/mec.14972\">10.1111/mec.14972</a>.","ieee":"R. Faria <i>et al.</i>, “Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes,” <i>Molecular Ecology</i>, vol. 28, no. 6. Wiley, pp. 1375–1393, 2019.","chicago":"Faria, Rui, Pragya Chaube, Hernán E. Morales, Tomas Larsson, Alan R. Lemmon, Emily M. Lemmon, Marina Rafajlović, et al. “Multiple Chromosomal Rearrangements in a Hybrid Zone between Littorina Saxatilis Ecotypes.” <i>Molecular Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/mec.14972\">https://doi.org/10.1111/mec.14972</a>.","short":"R. Faria, P. Chaube, H.E. Morales, T. Larsson, A.R. Lemmon, E.M. Lemmon, M. Rafajlović, M. Panova, M. Ravinet, K. Johannesson, A.M. Westram, R.K. Butlin, Molecular Ecology 28 (2019) 1375–1393.","ista":"Faria R, Chaube P, Morales HE, Larsson T, Lemmon AR, Lemmon EM, Rafajlović M, Panova M, Ravinet M, Johannesson K, Westram AM, Butlin RK. 2019. Multiple chromosomal rearrangements in a hybrid zone between Littorina saxatilis ecotypes. Molecular Ecology. 28(6), 1375–1393."},"ddc":["570"],"external_id":{"isi":["000465219200013"]},"intvolume":"        28","publication":"Molecular Ecology","type":"journal_article","doi":"10.1111/mec.14972","_id":"6095","quality_controlled":"1","page":"1375-1393","author":[{"first_name":"Rui","full_name":"Faria, Rui","last_name":"Faria"},{"first_name":"Pragya","full_name":"Chaube, Pragya","last_name":"Chaube"},{"full_name":"Morales, Hernán E.","first_name":"Hernán E.","last_name":"Morales"},{"last_name":"Larsson","full_name":"Larsson, Tomas","first_name":"Tomas"},{"last_name":"Lemmon","first_name":"Alan R.","full_name":"Lemmon, Alan R."},{"last_name":"Lemmon","first_name":"Emily M.","full_name":"Lemmon, Emily M."},{"last_name":"Rafajlović","first_name":"Marina","full_name":"Rafajlović, Marina"},{"last_name":"Panova","first_name":"Marina","full_name":"Panova, Marina"},{"full_name":"Ravinet, Mark","first_name":"Mark","last_name":"Ravinet"},{"last_name":"Johannesson","first_name":"Kerstin","full_name":"Johannesson, Kerstin"},{"last_name":"Westram","orcid":"0000-0003-1050-4969","id":"3C147470-F248-11E8-B48F-1D18A9856A87","first_name":"Anja M","full_name":"Westram, Anja M"},{"full_name":"Butlin, Roger K.","first_name":"Roger K.","last_name":"Butlin"}]},{"scopus_import":"1","isi":1,"abstract":[{"lang":"eng","text":"Light is a union of electric and magnetic fields, and nowhere is the complex relationship between these fields more evident than in the near fields of nanophotonic structures. There, complicated electric and magnetic fields varying over subwavelength scales are generally present, which results in photonic phenomena such as extraordinary optical momentum, superchiral fields, and a complex spatial evolution of optical singularities. An understanding of such phenomena requires nanoscale measurements of the complete optical field vector. Although the sensitivity of near- field scanning optical microscopy to the complete electromagnetic field was recently demonstrated, a separation of different components required a priori knowledge of the sample. Here, we introduce a robust algorithm that can disentangle all six electric and magnetic field components from a single near-field measurement without any numerical modeling of the structure. As examples, we unravel the fields of two prototypical nanophotonic structures: a photonic crystal waveguide and a plasmonic nanowire. These results pave the way for new studies of complex photonic phenomena at the nanoscale and for the design of structures that optimize their optical behavior."}],"day":"06","date_created":"2019-03-17T22:59:13Z","title":"A full vectorial mapping of nanophotonic light fields","language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:19Z","volume":8,"citation":{"ieee":"B. Le Feber, J. E. Sipe, M. Wulf, L. Kuipers, and N. Rotenberg, “A full vectorial mapping of nanophotonic light fields,” <i>Light: Science and Applications</i>, vol. 8, no. 1. Springer Nature, 2019.","mla":"Le Feber, B., et al. “A Full Vectorial Mapping of Nanophotonic Light Fields.” <i>Light: Science and Applications</i>, vol. 8, no. 1, 28, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41377-019-0124-3\">10.1038/s41377-019-0124-3</a>.","ama":"Le Feber B, Sipe JE, Wulf M, Kuipers L, Rotenberg N. A full vectorial mapping of nanophotonic light fields. <i>Light: Science and Applications</i>. 2019;8(1). doi:<a href=\"https://doi.org/10.1038/s41377-019-0124-3\">10.1038/s41377-019-0124-3</a>","apa":"Le Feber, B., Sipe, J. E., Wulf, M., Kuipers, L., &#38; Rotenberg, N. (2019). A full vectorial mapping of nanophotonic light fields. <i>Light: Science and Applications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41377-019-0124-3\">https://doi.org/10.1038/s41377-019-0124-3</a>","ista":"Le Feber B, Sipe JE, Wulf M, Kuipers L, Rotenberg N. 2019. A full vectorial mapping of nanophotonic light fields. Light: Science and Applications. 8(1), 28.","short":"B. Le Feber, J.E. Sipe, M. Wulf, L. Kuipers, N. Rotenberg, Light: Science and Applications 8 (2019).","chicago":"Le Feber, B., J. E. Sipe, Matthias Wulf, L. Kuipers, and N. Rotenberg. “A Full Vectorial Mapping of Nanophotonic Light Fields.” <i>Light: Science and Applications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41377-019-0124-3\">https://doi.org/10.1038/s41377-019-0124-3</a>."},"external_id":{"arxiv":["1803.10145"],"isi":["000460470700004"]},"ddc":["530"],"arxiv":1,"intvolume":"         8","publication":"Light: Science and Applications","type":"journal_article","doi":"10.1038/s41377-019-0124-3","_id":"6102","quality_controlled":"1","author":[{"last_name":"Le Feber","first_name":"B.","full_name":"Le Feber, B."},{"full_name":"Sipe, J. E.","first_name":"J. E.","last_name":"Sipe"},{"full_name":"Wulf, Matthias","first_name":"Matthias","id":"45598606-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6613-1378","last_name":"Wulf"},{"last_name":"Kuipers","first_name":"L.","full_name":"Kuipers, L."},{"last_name":"Rotenberg","first_name":"N.","full_name":"Rotenberg, N."}],"publisher":"Springer Nature","date_published":"2019-03-06T00:00:00Z","month":"03","date_updated":"2025-07-10T11:53:10Z","publication_status":"published","article_processing_charge":"No","article_number":"28","department":[{"_id":"JoFi"}],"oa":1,"file":[{"date_updated":"2020-07-14T12:47:19Z","creator":"dernst","file_size":1119947,"checksum":"d71e528cff9c56f70ccc29dd7005257f","access_level":"open_access","content_type":"application/pdf","file_id":"6108","relation":"main_file","file_name":"2019_Light_LeFeber.pdf","date_created":"2019-03-18T08:08:22Z"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication_identifier":{"issn":["2095-5545"],"eissn":["2047-7538"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","issue":"1","year":"2019","status":"public"},{"intvolume":"        60","external_id":{"pmid":["30668780"],"isi":["000459634300002"]},"citation":{"apa":"Zwiewka, M., Bielach, A., Tamizhselvan, P., Madhavan, S., Ryad, E. E., Tan, S., … Tognetti, V. B. (2019). Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. <i>Plant and Cell Physiology</i>. Oxford University Press. <a href=\"https://doi.org/10.1093/pcp/pcz001\">https://doi.org/10.1093/pcp/pcz001</a>","ama":"Zwiewka M, Bielach A, Tamizhselvan P, et al. Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. <i>Plant and Cell Physiology</i>. 2019;60(2):255-273. doi:<a href=\"https://doi.org/10.1093/pcp/pcz001\">10.1093/pcp/pcz001</a>","ieee":"M. Zwiewka <i>et al.</i>, “Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking,” <i>Plant and Cell Physiology</i>, vol. 60, no. 2. Oxford University Press, pp. 255–273, 2019.","mla":"Zwiewka, Marta, et al. “Root Adaptation to H2O2-Induced Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.” <i>Plant and Cell Physiology</i>, vol. 60, no. 2, Oxford University Press, 2019, pp. 255–73, doi:<a href=\"https://doi.org/10.1093/pcp/pcz001\">10.1093/pcp/pcz001</a>.","chicago":"Zwiewka, Marta, Agnieszka Bielach, Prashanth Tamizhselvan, Sharmila Madhavan, Eman Elrefaay Ryad, Shutang Tan, Mónika Hrtyan, et al. “Root Adaptation to H2O2-Induced Oxidative Stress by ARF-GEF BEN1- and Cytoskeleton-Mediated PIN2 Trafficking.” <i>Plant and Cell Physiology</i>. Oxford University Press, 2019. <a href=\"https://doi.org/10.1093/pcp/pcz001\">https://doi.org/10.1093/pcp/pcz001</a>.","short":"M. Zwiewka, A. Bielach, P. Tamizhselvan, S. Madhavan, E.E. Ryad, S. Tan, M. Hrtyan, P. Dobrev, R. Vanková, J. Friml, V.B. Tognetti, Plant and Cell Physiology 60 (2019) 255–273.","ista":"Zwiewka M, Bielach A, Tamizhselvan P, Madhavan S, Ryad EE, Tan S, Hrtyan M, Dobrev P, Vanková R, Friml J, Tognetti VB. 2019. Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking. Plant and Cell Physiology. 60(2), 255–273."},"type":"journal_article","publication":"Plant and Cell Physiology","_id":"6104","doi":"10.1093/pcp/pcz001","author":[{"last_name":"Zwiewka","first_name":"Marta","full_name":"Zwiewka, Marta"},{"last_name":"Bielach","full_name":"Bielach, Agnieszka","first_name":"Agnieszka"},{"last_name":"Tamizhselvan","first_name":"Prashanth","full_name":"Tamizhselvan, Prashanth"},{"full_name":"Madhavan, Sharmila","first_name":"Sharmila","last_name":"Madhavan"},{"last_name":"Ryad","full_name":"Ryad, Eman Elrefaay","first_name":"Eman Elrefaay"},{"last_name":"Tan","orcid":"0000-0002-0471-8285","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","first_name":"Shutang","full_name":"Tan, Shutang"},{"id":"45A71A74-F248-11E8-B48F-1D18A9856A87","first_name":"Mónika","full_name":"Hrtyan, Mónika","last_name":"Hrtyan"},{"last_name":"Dobrev","first_name":"Petre","full_name":"Dobrev, Petre"},{"first_name":"Radomira","full_name":"Vanková, Radomira","last_name":"Vanková"},{"full_name":"Friml, Jiří","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"last_name":"Tognetti","full_name":"Tognetti, Vanesa B.","first_name":"Vanesa B."}],"page":"255-273","quality_controlled":"1","pmid":1,"isi":1,"scopus_import":"1","date_created":"2019-03-17T22:59:14Z","day":"01","abstract":[{"lang":"eng","text":"Abiotic stress poses constant challenges for plant survival and is a serious problem for global agricultural productivity. On a molecular level, stress conditions result in elevation of reactive oxygen species (ROS) production causing oxidative stress associated with oxidation of proteins and nucleic acids as well as impairment of membrane functions. Adaptation of root growth to ROS accumulation is facilitated through modification of auxin and cytokinin hormone homeostasis. Here, we report that in Arabidopsis root meristem, ROS-induced changes of auxin levels correspond to decreased abundance of PIN auxin efflux carriers at the plasma membrane (PM). Specifically, increase in H2O2 levels affects PIN2 endocytic recycling. We show that the PIN2 intracellular trafficking during adaptation to oxidative stress requires the function of the ADP-ribosylation factor (ARF)-guanine-nucleotide exchange factor (GEF) BEN1, an actin-associated regulator of the trafficking from the PM to early endosomes and, presumably, indirectly, trafficking to the vacuoles. We propose that H2O2 levels affect the actin dynamics thus modulating ARF-GEF-dependent trafficking of PIN2. This mechanism provides a way how root growth acclimates to stress and adapts to a changing environment."}],"volume":60,"language":[{"iso":"eng"}],"title":"Root adaptation to H2O2-induced oxidative stress by ARF-GEF BEN1- and cytoskeleton-mediated PIN2 trafficking","oa_version":"None","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"eissn":["1471-9053"],"issn":["0032-0781"]},"year":"2019","status":"public","issue":"2","publisher":"Oxford University Press","publication_status":"published","date_updated":"2023-08-25T08:05:28Z","date_published":"2019-02-01T00:00:00Z","month":"02","department":[{"_id":"JiFr"}],"article_processing_charge":"No"},{"status":"public","year":"2019","issue":"4","has_accepted_license":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0021-8790"],"eissn":["1365-2656"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"file":[{"file_size":1460662,"access_level":"open_access","checksum":"405cde15120de26018b3bd0dfa29986c","content_type":"application/pdf","creator":"dernst","date_updated":"2020-07-14T12:47:19Z","date_created":"2019-03-18T07:43:06Z","file_name":"2019_JournalAnimalEcology_Kutzer.pdf","relation":"main_file","file_id":"6107"}],"oa_version":"Published Version","oa":1,"department":[{"_id":"SyCr"}],"article_processing_charge":"No","month":"04","article_type":"original","date_published":"2019-04-01T00:00:00Z","date_updated":"2025-07-10T11:53:10Z","publication_status":"published","ec_funded":1,"publisher":"Wiley","page":"566-578","author":[{"orcid":"0000-0002-8696-6978","last_name":"Kutzer","first_name":"Megan","full_name":"Kutzer, Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"},{"last_name":"Armitage","first_name":"Sophie A.O.","full_name":"Armitage, Sophie A.O."}],"quality_controlled":"1","project":[{"name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"doi":"10.1111/1365-2656.12953","_id":"6105","type":"journal_article","publication":"Journal of Animal Ecology","intvolume":"        88","citation":{"ieee":"M. Kutzer, J. Kurtz, and S. A. O. Armitage, “A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance,” <i>Journal of Animal Ecology</i>, vol. 88, no. 4. Wiley, pp. 566–578, 2019.","mla":"Kutzer, Megan, et al. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” <i>Journal of Animal Ecology</i>, vol. 88, no. 4, Wiley, 2019, pp. 566–78, doi:<a href=\"https://doi.org/10.1111/1365-2656.12953\">10.1111/1365-2656.12953</a>.","apa":"Kutzer, M., Kurtz, J., &#38; Armitage, S. A. O. (2019). A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. <i>Journal of Animal Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/1365-2656.12953\">https://doi.org/10.1111/1365-2656.12953</a>","ama":"Kutzer M, Kurtz J, Armitage SAO. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. <i>Journal of Animal Ecology</i>. 2019;88(4):566-578. doi:<a href=\"https://doi.org/10.1111/1365-2656.12953\">10.1111/1365-2656.12953</a>","ista":"Kutzer M, Kurtz J, Armitage SAO. 2019. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Journal of Animal Ecology. 88(4), 566–578.","chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” <i>Journal of Animal Ecology</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/1365-2656.12953\">https://doi.org/10.1111/1365-2656.12953</a>.","short":"M. Kutzer, J. Kurtz, S.A.O. Armitage, Journal of Animal Ecology 88 (2019) 566–578."},"ddc":["570"],"external_id":{"isi":["000467994800007"]},"file_date_updated":"2020-07-14T12:47:19Z","volume":88,"title":"A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance","related_material":{"record":[{"status":"public","relation":"research_data","id":"9806"}]},"language":[{"iso":"eng"}],"day":"01","abstract":[{"lang":"eng","text":"    Hosts can alter their strategy towards pathogens during their lifetime; that is, they can show phenotypic plasticity in immunity or life history. Immune priming is one such example, where a previous encounter with a pathogen confers enhanced protection upon secondary challenge, resulting in reduced pathogen load (i.e., resistance) and improved host survival. However, an initial encounter might also enhance tolerance, particularly to less virulent opportunistic pathogens that establish persistent infections. In this scenario, individuals are better able to reduce the negative fecundity consequences that result from a high pathogen burden. Finally, previous exposure may also lead to life‐history adjustments, such as terminal investment into reproduction.\r\n    Using different Drosophila melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas entomophila, we tested whether previous exposure results in resistance or tolerance and whether it modifies immune gene expression during an acute‐phase infection (one day post‐challenge). We then asked whether previous pathogen exposure affects chronic‐phase pathogen persistence and longer‐term survival (28 days post‐challenge).\r\n    We predicted that previous exposure would increase host resistance to an early stage bacterial infection while it might come at a cost to host fecundity tolerance. We reasoned that resistance would be due in part to stronger immune gene expression after challenge. We expected that previous exposure would improve long‐term survival, that it would reduce infection persistence, and we expected to find genetic variation in these responses.\r\n    We found that previous exposure to P. entomophila weakened host resistance to a second infection independent of genotype and had no effect on immune gene expression. Fecundity tolerance showed genotypic variation but was not influenced by previous exposure. However, L. lactis persisted as a chronic infection, whereas survivors cleared the more pathogenic P. entomophila infection.\r\n    To our knowledge, this is the first study that addresses host tolerance to bacteria in relation to previous exposure, taking a multi‐faceted approach to address the topic. Our results suggest that previous exposure comes with transient costs to resistance during the early stage of infection in this host–pathogen system and that infection persistence may be bacterium‐specific.\r\n"}],"date_created":"2019-03-17T22:59:15Z","isi":1,"scopus_import":"1"},{"publisher":"American Physical Society","date_published":"2019-03-22T00:00:00Z","month":"03","article_type":"original","date_updated":"2023-09-05T12:11:13Z","publication_status":"published","article_processing_charge":"No","article_number":"094205","department":[{"_id":"MaSe"}],"oa":1,"oa_version":"Preprint","publication_identifier":{"issn":["2469-9950"],"eissn":["2469-9969"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","year":"2019","status":"public","issue":"9","scopus_import":"1","isi":1,"abstract":[{"text":"We propose a scaling theory for the many-body localization (MBL) phase transition in one dimension, building on the idea that it proceeds via a “quantum avalanche.” We argue that the critical properties can be captured at a coarse-grained level by a Kosterlitz-Thouless (KT) renormalization group (RG) flow. On phenomenological grounds, we identify the scaling variables as the density of thermal regions and the length scale that controls the decay of typical matrix elements. Within this KT picture, the MBL phase is a line of fixed points that terminates at the delocalization transition. We discuss two possible scenarios distinguished by the distribution of rare, fractal thermal inclusions within the MBL phase. In the first scenario, these regions have a stretched exponential distribution in the MBL phase. In the second scenario, the near-critical MBL phase hosts rare thermal regions that are power-law-distributed in size. This points to the existence of a second transition within the MBL phase, at which these power laws change to the stretched exponential form expected at strong disorder. We numerically simulate two different phenomenological RGs previously proposed to describe the MBL transition. Both RGs display a universal power-law length distribution of thermal regions at the transition with a critical exponent αc=2, and continuously varying exponents in the MBL phase consistent with the KT picture.","lang":"eng"}],"day":"22","date_created":"2019-03-25T07:32:08Z","title":"Kosterlitz-Thouless scaling at many-body localization phase transitions","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://arxiv.org/abs/1811.03103","open_access":"1"}],"volume":99,"citation":{"ista":"Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. 2019. Kosterlitz-Thouless scaling at many-body localization phase transitions. Physical Review B. 99(9), 094205.","short":"P.T. Dumitrescu, A. Goremykina, S.A. Parameswaran, M. Serbyn, R. Vasseur, Physical Review B 99 (2019).","chicago":"Dumitrescu, Philipp T., Anna Goremykina, Siddharth A. Parameswaran, Maksym Serbyn, and Romain Vasseur. “Kosterlitz-Thouless Scaling at Many-Body Localization Phase Transitions.” <i>Physical Review B</i>. American Physical Society, 2019. <a href=\"https://doi.org/10.1103/physrevb.99.094205\">https://doi.org/10.1103/physrevb.99.094205</a>.","ieee":"P. T. Dumitrescu, A. Goremykina, S. A. Parameswaran, M. Serbyn, and R. Vasseur, “Kosterlitz-Thouless scaling at many-body localization phase transitions,” <i>Physical Review B</i>, vol. 99, no. 9. American Physical Society, 2019.","mla":"Dumitrescu, Philipp T., et al. “Kosterlitz-Thouless Scaling at Many-Body Localization Phase Transitions.” <i>Physical Review B</i>, vol. 99, no. 9, 094205, American Physical Society, 2019, doi:<a href=\"https://doi.org/10.1103/physrevb.99.094205\">10.1103/physrevb.99.094205</a>.","ama":"Dumitrescu PT, Goremykina A, Parameswaran SA, Serbyn M, Vasseur R. Kosterlitz-Thouless scaling at many-body localization phase transitions. <i>Physical Review B</i>. 2019;99(9). doi:<a href=\"https://doi.org/10.1103/physrevb.99.094205\">10.1103/physrevb.99.094205</a>","apa":"Dumitrescu, P. T., Goremykina, A., Parameswaran, S. A., Serbyn, M., &#38; Vasseur, R. (2019). Kosterlitz-Thouless scaling at many-body localization phase transitions. <i>Physical Review B</i>. American Physical Society. <a href=\"https://doi.org/10.1103/physrevb.99.094205\">https://doi.org/10.1103/physrevb.99.094205</a>"},"external_id":{"arxiv":["1811.03103"],"isi":["000462883200001"]},"arxiv":1,"intvolume":"        99","type":"journal_article","publication":"Physical Review B","doi":"10.1103/physrevb.99.094205","_id":"6174","quality_controlled":"1","author":[{"last_name":"Dumitrescu","full_name":"Dumitrescu, Philipp T.","first_name":"Philipp T."},{"first_name":"Anna","full_name":"Goremykina, Anna","last_name":"Goremykina"},{"last_name":"Parameswaran","first_name":"Siddharth A.","full_name":"Parameswaran, Siddharth A."},{"full_name":"Serbyn, Maksym","first_name":"Maksym","id":"47809E7E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2399-5827","last_name":"Serbyn"},{"last_name":"Vasseur","first_name":"Romain","full_name":"Vasseur, Romain"}]},{"ec_funded":1,"publisher":"Institute of Science and Technology Austria","month":"03","date_published":"2019-03-18T00:00:00Z","date_updated":"2026-04-08T13:55:03Z","publication_status":"published","department":[{"_id":"LaEr"}],"article_processing_charge":"No","oa":1,"file":[{"file_id":"6180","file_name":"2019_Schroeder_Thesis.tar.gz","date_created":"2019-03-28T08:53:52Z","relation":"source_file","date_updated":"2020-07-14T12:47:21Z","creator":"dernst","checksum":"6926f66f28079a81c4937e3764be00fc","content_type":"application/x-gzip","access_level":"closed","file_size":7104482},{"date_created":"2019-03-28T08:53:52Z","file_name":"2019_Schroeder_Thesis.pdf","relation":"main_file","file_id":"6181","content_type":"application/pdf","file_size":4228794,"checksum":"7d0ebb8d1207e89768cdd497a5bf80fb","access_level":"open_access","creator":"dernst","date_updated":"2020-07-14T12:47:21Z"}],"alternative_title":["ISTA Thesis"],"oa_version":"Published Version","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","OA_place":"publisher","publication_identifier":{"issn":["2663-337X"]},"has_accepted_license":"1","corr_author":"1","degree_awarded":"PhD","year":"2019","status":"public","supervisor":[{"first_name":"László","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","last_name":"Erdös"}],"abstract":[{"text":"In the first part of this thesis we consider large random matrices with arbitrary expectation and a general slowly decaying correlation among its entries. We prove universality of the local eigenvalue statistics and optimal local laws for the resolvent in the bulk and edge regime. The main novel tool is a systematic diagrammatic control of a multivariate cumulant expansion.\r\nIn the second part we consider Wigner-type matrices and show that at any cusp singularity of the limiting eigenvalue distribution the local eigenvalue statistics are uni- versal and form a Pearcey process. Since the density of states typically exhibits only square root or cubic root cusp singularities, our work complements previous results on the bulk and edge universality and it thus completes the resolution of the Wigner- Dyson-Mehta universality conjecture for the last remaining universality type. Our analysis holds not only for exact cusps, but approximate cusps as well, where an ex- tended Pearcey process emerges. As a main technical ingredient we prove an optimal local law at the cusp, and extend the fast relaxation to equilibrium of the Dyson Brow- nian motion to the cusp regime.\r\nIn the third and final part we explore the entrywise linear statistics of Wigner ma- trices and identify the fluctuations for a large class of test functions with little regularity. This enables us to study the rectangular Young diagram obtained from the interlacing eigenvalues of the random matrix and its minor, and we find that, despite having the same limit, the fluctuations differ from those of the algebraic Young tableaux equipped with the Plancharel measure.","lang":"eng"}],"day":"18","date_created":"2019-03-28T08:58:59Z","file_date_updated":"2020-07-14T12:47:21Z","title":"From Dyson to Pearcey: Universal statistics in random matrix theory","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"6184","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"6186","relation":"part_of_dissertation"},{"id":"6185","relation":"part_of_dissertation","status":"public"},{"status":"public","id":"1012","relation":"part_of_dissertation"},{"status":"public","relation":"part_of_dissertation","id":"1144"},{"status":"public","id":"6182","relation":"part_of_dissertation"}]},"citation":{"ista":"Schröder DJ. 2019. From Dyson to Pearcey: Universal statistics in random matrix theory. Institute of Science and Technology Austria.","chicago":"Schröder, Dominik J. “From Dyson to Pearcey: Universal Statistics in Random Matrix Theory.” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">https://doi.org/10.15479/AT:ISTA:th6179</a>.","short":"D.J. Schröder, From Dyson to Pearcey: Universal Statistics in Random Matrix Theory, Institute of Science and Technology Austria, 2019.","mla":"Schröder, Dominik J. <i>From Dyson to Pearcey: Universal Statistics in Random Matrix Theory</i>. Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">10.15479/AT:ISTA:th6179</a>.","ieee":"D. J. Schröder, “From Dyson to Pearcey: Universal statistics in random matrix theory,” Institute of Science and Technology Austria, 2019.","apa":"Schröder, D. J. (2019). <i>From Dyson to Pearcey: Universal statistics in random matrix theory</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">https://doi.org/10.15479/AT:ISTA:th6179</a>","ama":"Schröder DJ. From Dyson to Pearcey: Universal statistics in random matrix theory. 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">10.15479/AT:ISTA:th6179</a>"},"ddc":["515","519"],"type":"dissertation","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804"}],"doi":"10.15479/AT:ISTA:th6179","_id":"6179","page":"375","author":[{"last_name":"Schröder","orcid":"0000-0002-2904-1856","id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J","full_name":"Schröder, Dominik J"}]},{"isi":1,"scopus_import":"1","volume":7,"file_date_updated":"2020-07-14T12:47:22Z","related_material":{"record":[{"status":"public","id":"6179","relation":"dissertation_contains"}]},"language":[{"iso":"eng"}],"title":"Random matrices with slow correlation decay","date_created":"2019-03-28T09:05:23Z","abstract":[{"lang":"eng","text":"We consider large random matrices with a general slowly decaying correlation among its entries. We prove universality of the local eigenvalue statistics and optimal local laws for the resolvent away from the spectral edges, generalizing the recent result of Ajanki et al. [‘Stability of the matrix Dyson equation and random matrices with correlations’, Probab. Theory Related Fields 173(1–2) (2019), 293–373] to allow slow correlation decay and arbitrary expectation. The main novel tool is\r\na systematic diagrammatic control of a multivariate cumulant expansion."}],"day":"26","publication":"Forum of Mathematics, Sigma","type":"journal_article","intvolume":"         7","arxiv":1,"ddc":["510"],"external_id":{"isi":["000488847100001"],"arxiv":["1705.10661"]},"citation":{"ista":"Erdös L, Krüger TH, Schröder DJ. 2019. Random matrices with slow correlation decay. Forum of Mathematics, Sigma. 7, e8.","short":"L. Erdös, T.H. Krüger, D.J. Schröder, Forum of Mathematics, Sigma 7 (2019).","chicago":"Erdös, László, Torben H Krüger, and Dominik J Schröder. “Random Matrices with Slow Correlation Decay.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2019. <a href=\"https://doi.org/10.1017/fms.2019.2\">https://doi.org/10.1017/fms.2019.2</a>.","mla":"Erdös, László, et al. “Random Matrices with Slow Correlation Decay.” <i>Forum of Mathematics, Sigma</i>, vol. 7, e8, Cambridge University Press, 2019, doi:<a href=\"https://doi.org/10.1017/fms.2019.2\">10.1017/fms.2019.2</a>.","ieee":"L. Erdös, T. H. Krüger, and D. J. Schröder, “Random matrices with slow correlation decay,” <i>Forum of Mathematics, Sigma</i>, vol. 7. Cambridge University Press, 2019.","ama":"Erdös L, Krüger TH, Schröder DJ. Random matrices with slow correlation decay. <i>Forum of Mathematics, Sigma</i>. 2019;7. doi:<a href=\"https://doi.org/10.1017/fms.2019.2\">10.1017/fms.2019.2</a>","apa":"Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2019). Random matrices with slow correlation decay. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2019.2\">https://doi.org/10.1017/fms.2019.2</a>"},"author":[{"last_name":"Erdös","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","first_name":"László","full_name":"Erdös, László"},{"full_name":"Krüger, Torben H","first_name":"Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4821-3297","last_name":"Krüger"},{"first_name":"Dominik J","full_name":"Schröder, Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2904-1856","last_name":"Schröder"}],"quality_controlled":"1","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"338804","name":"Random matrices, universality and disordered quantum systems"}],"_id":"6182","doi":"10.1017/fms.2019.2","publication_status":"published","date_updated":"2026-04-08T13:55:03Z","article_type":"original","date_published":"2019-03-26T00:00:00Z","month":"03","ec_funded":1,"publisher":"Cambridge University Press","oa":1,"article_number":"e8","department":[{"_id":"LaEr"}],"article_processing_charge":"No","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_identifier":{"eissn":["2050-5094"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"date_created":"2019-09-17T14:24:13Z","file_name":"2019_Forum_Erdoes.pdf","relation":"main_file","file_id":"6883","access_level":"open_access","file_size":1520344,"checksum":"933a472568221c73b2c3ce8c87bf6d15","content_type":"application/pdf","creator":"dernst","date_updated":"2020-07-14T12:47:22Z"}],"year":"2019","status":"public","has_accepted_license":"1","corr_author":"1"},{"department":[{"_id":"LaEr"}],"article_processing_charge":"No","oa":1,"ec_funded":1,"publisher":"MSP","date_published":"2019-10-12T00:00:00Z","article_type":"original","month":"10","date_updated":"2026-04-08T13:55:02Z","publication_status":"published","year":"2019","issue":"4","status":"public","oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["2578-5893"],"eissn":["2578-5885"]},"day":"12","abstract":[{"text":"We prove that the local eigenvalue statistics of real symmetric Wigner-type\r\nmatrices near the cusp points of the eigenvalue density are universal. Together\r\nwith the companion paper [arXiv:1809.03971], which proves the same result for\r\nthe complex Hermitian symmetry class, this completes the last remaining case of\r\nthe Wigner-Dyson-Mehta universality conjecture after bulk and edge\r\nuniversalities have been established in the last years. We extend the recent\r\nDyson Brownian motion analysis at the edge [arXiv:1712.03881] to the cusp\r\nregime using the optimal local law from [arXiv:1809.03971] and the accurate\r\nlocal shape analysis of the density from [arXiv:1506.05095, arXiv:1804.07752].\r\nWe also present a PDE-based method to improve the estimate on eigenvalue\r\nrigidity via the maximum principle of the heat flow related to the Dyson\r\nBrownian motion.","lang":"eng"}],"date_created":"2019-03-28T10:21:17Z","volume":1,"title":"Cusp universality for random matrices, II: The real symmetric case","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"6179"}]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1811.04055"}],"language":[{"iso":"eng"}],"scopus_import":"1","project":[{"name":"Random matrices, universality and disordered quantum systems","grant_number":"338804","call_identifier":"FP7","_id":"258DCDE6-B435-11E9-9278-68D0E5697425"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020"}],"doi":"10.2140/paa.2019.1.615","_id":"6186","page":"615–707","author":[{"last_name":"Cipolloni","orcid":"0000-0002-4901-7992","id":"42198EFA-F248-11E8-B48F-1D18A9856A87","full_name":"Cipolloni, Giorgio","first_name":"Giorgio"},{"orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-4821-3297","last_name":"Krüger","first_name":"Torben H","full_name":"Krüger, Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Schröder, Dominik J","first_name":"Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2904-1856","last_name":"Schröder"}],"quality_controlled":"1","arxiv":1,"intvolume":"         1","citation":{"apa":"Cipolloni, G., Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2019). Cusp universality for random matrices, II: The real symmetric case. <i>Pure and Applied Analysis </i>. MSP. <a href=\"https://doi.org/10.2140/paa.2019.1.615\">https://doi.org/10.2140/paa.2019.1.615</a>","ama":"Cipolloni G, Erdös L, Krüger TH, Schröder DJ. Cusp universality for random matrices, II: The real symmetric case. <i>Pure and Applied Analysis </i>. 2019;1(4):615–707. doi:<a href=\"https://doi.org/10.2140/paa.2019.1.615\">10.2140/paa.2019.1.615</a>","ieee":"G. Cipolloni, L. Erdös, T. H. Krüger, and D. J. Schröder, “Cusp universality for random matrices, II: The real symmetric case,” <i>Pure and Applied Analysis </i>, vol. 1, no. 4. MSP, pp. 615–707, 2019.","mla":"Cipolloni, Giorgio, et al. “Cusp Universality for Random Matrices, II: The Real Symmetric Case.” <i>Pure and Applied Analysis </i>, vol. 1, no. 4, MSP, 2019, pp. 615–707, doi:<a href=\"https://doi.org/10.2140/paa.2019.1.615\">10.2140/paa.2019.1.615</a>.","chicago":"Cipolloni, Giorgio, László Erdös, Torben H Krüger, and Dominik J Schröder. “Cusp Universality for Random Matrices, II: The Real Symmetric Case.” <i>Pure and Applied Analysis </i>. MSP, 2019. <a href=\"https://doi.org/10.2140/paa.2019.1.615\">https://doi.org/10.2140/paa.2019.1.615</a>.","short":"G. Cipolloni, L. Erdös, T.H. Krüger, D.J. Schröder, Pure and Applied Analysis  1 (2019) 615–707.","ista":"Cipolloni G, Erdös L, Krüger TH, Schröder DJ. 2019. Cusp universality for random matrices, II: The real symmetric case. Pure and Applied Analysis . 1(4), 615–707."},"external_id":{"arxiv":["1811.04055"]},"type":"journal_article","publication":"Pure and Applied Analysis "},{"oa":1,"article_processing_charge":"No","department":[{"_id":"DaSi"}],"date_updated":"2026-06-18T19:00:54Z","publication_status":"published","month":"03","article_type":"original","date_published":"2019-03-01T00:00:00Z","publisher":"AACR","issue":"3","status":"public","year":"2019","publication_identifier":{"eissn":["1557-3125"],"issn":["1541-7786"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://doi.org/10.1158/1541-7786.MCR-18-0530","open_access":"1"}],"title":"CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis","volume":17,"date_created":"2019-03-31T21:59:12Z","day":"01","abstract":[{"lang":"eng","text":"Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation, but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Similar levels of circulating monocytes and equal leukocyte recruitment to metastatic lesions of Ccr2ecKO and Ccr2fl/fl littermates were observed. The absence of endothelial Ccr2 strongly reduced pulmonary metastasis, while the primary tumor growth was unaffected. Despite a comparable cytokine milieu in Ccr2ecKO and Ccr2fl/fl littermates the absence of vascular permeability induction was observed only in Ccr2ecKO mice. CCL2 stimulation of pulmonary endothelial cells resulted in increased phosphorylation of MLC2, endothelial cell retraction, and vascular leakiness that was blocked by an addition of a CCR2 inhibitor. These data demonstrate that endothelial CCR2 expression is required for tumor cell extravasation and pulmonary metastasis.\r\n\r\nImplications: The findings provide mechanistic insight into how CCL2–CCR2 signaling in endothelial cells promotes their activation through myosin light chain phosphorylation, resulting in endothelial retraction and enhanced tumor cell migration and metastasis."}],"scopus_import":"1","isi":1,"pmid":1,"quality_controlled":"1","page":"783-793","author":[{"id":"3047D808-F248-11E8-B48F-1D18A9856A87","full_name":"Roblek, Marko","first_name":"Marko","last_name":"Roblek","orcid":"0000-0001-9588-1389"},{"last_name":"Protsyuk","first_name":"Darya","full_name":"Protsyuk, Darya"},{"last_name":"Becker","full_name":"Becker, Paul F.","first_name":"Paul F."},{"last_name":"Stefanescu","full_name":"Stefanescu, Cristina","first_name":"Cristina"},{"first_name":"Christian","full_name":"Gorzelanny, Christian","last_name":"Gorzelanny"},{"last_name":"Glaus Garzon","first_name":"Jesus F.","full_name":"Glaus Garzon, Jesus F."},{"full_name":"Knopfova, Lucia","first_name":"Lucia","last_name":"Knopfova"},{"first_name":"Mathias","full_name":"Heikenwalder, Mathias","last_name":"Heikenwalder"},{"last_name":"Luckow","first_name":"Bruno","full_name":"Luckow, Bruno"},{"last_name":"Schneider","first_name":"Stefan W.","full_name":"Schneider, Stefan W."},{"last_name":"Borsig","full_name":"Borsig, Lubor","first_name":"Lubor"}],"_id":"6190","doi":"10.1158/1541-7786.MCR-18-0530","publication":"Molecular Cancer Research","type":"journal_article","external_id":{"pmid":["30552233"],"isi":["000460099800012"]},"ddc":["570"],"citation":{"short":"M. Roblek, D. Protsyuk, P.F. Becker, C. Stefanescu, C. Gorzelanny, J.F. Glaus Garzon, L. Knopfova, M. Heikenwalder, B. Luckow, S.W. Schneider, L. Borsig, Molecular Cancer Research 17 (2019) 783–793.","chicago":"Roblek, Marko, Darya Protsyuk, Paul F. Becker, Cristina Stefanescu, Christian Gorzelanny, Jesus F. Glaus Garzon, Lucia Knopfova, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>. AACR, 2019. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>.","ista":"Roblek M, Protsyuk D, Becker PF, Stefanescu C, Gorzelanny C, Glaus Garzon JF, Knopfova L, Heikenwalder M, Luckow B, Schneider SW, Borsig L. 2019. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. Molecular Cancer Research. 17(3), 783–793.","ama":"Roblek M, Protsyuk D, Becker PF, et al. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. 2019;17(3):783-793. doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>","apa":"Roblek, M., Protsyuk, D., Becker, P. F., Stefanescu, C., Gorzelanny, C., Glaus Garzon, J. F., … Borsig, L. (2019). CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. AACR. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>","ieee":"M. Roblek <i>et al.</i>, “CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis,” <i>Molecular Cancer Research</i>, vol. 17, no. 3. AACR, pp. 783–793, 2019.","mla":"Roblek, Marko, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>, vol. 17, no. 3, AACR, 2019, pp. 783–93, doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>."},"intvolume":"        17"},{"oa_version":"Published Version","file":[{"date_updated":"2020-07-14T12:47:23Z","creator":"dernst","content_type":"application/pdf","file_size":3456045,"checksum":"8b67eee0ea8e5db61583e4d485215258","access_level":"open_access","file_id":"6193","file_name":"2019_PNAS_Recho.pdf","date_created":"2019-04-03T14:10:30Z","relation":"main_file"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","corr_author":"1","year":"2019","issue":"12","status":"public","publisher":"National Academy of Sciences","date_updated":"2025-07-10T11:53:14Z","publication_status":"published","month":"03","date_published":"2019-03-19T00:00:00Z","article_processing_charge":"No","department":[{"_id":"EdHa"}],"oa":1,"ddc":["570"],"external_id":{"pmid":["30819884"],"isi":["000461679000027"]},"citation":{"mla":"Recho, Pierre, et al. “Theory of Mechanochemical Patterning in Biphasic Biological Tissues.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 12, National Academy of Sciences, 2019, pp. 5344–49, doi:<a href=\"https://doi.org/10.1073/pnas.1813255116\">10.1073/pnas.1813255116</a>.","ieee":"P. Recho, A. Hallou, and E. B. Hannezo, “Theory of mechanochemical patterning in biphasic biological tissues,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 12. National Academy of Sciences, pp. 5344–5349, 2019.","ama":"Recho P, Hallou A, Hannezo EB. Theory of mechanochemical patterning in biphasic biological tissues. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2019;116(12):5344-5349. doi:<a href=\"https://doi.org/10.1073/pnas.1813255116\">10.1073/pnas.1813255116</a>","apa":"Recho, P., Hallou, A., &#38; Hannezo, E. B. (2019). Theory of mechanochemical patterning in biphasic biological tissues. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1813255116\">https://doi.org/10.1073/pnas.1813255116</a>","ista":"Recho P, Hallou A, Hannezo EB. 2019. Theory of mechanochemical patterning in biphasic biological tissues. Proceedings of the National Academy of Sciences of the United States of America. 116(12), 5344–5349.","short":"P. Recho, A. Hallou, E.B. Hannezo, Proceedings of the National Academy of Sciences of the United States of America 116 (2019) 5344–5349.","chicago":"Recho, Pierre, Adrien Hallou, and Edouard B Hannezo. “Theory of Mechanochemical Patterning in Biphasic Biological Tissues.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2019. <a href=\"https://doi.org/10.1073/pnas.1813255116\">https://doi.org/10.1073/pnas.1813255116</a>."},"intvolume":"       116","publication":"Proceedings of the National Academy of Sciences of the United States of America","type":"journal_article","_id":"6191","doi":"10.1073/pnas.1813255116","project":[{"call_identifier":"FWF","grant_number":"P31639","name":"Active mechano-chemical description of the cell cytoskeleton","_id":"268294B6-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","page":"5344-5349","author":[{"full_name":"Recho, Pierre","first_name":"Pierre","last_name":"Recho"},{"full_name":"Hallou, Adrien","first_name":"Adrien","last_name":"Hallou"},{"orcid":"0000-0001-6005-1561","last_name":"Hannezo","first_name":"Edouard B","full_name":"Hannezo, Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"}],"pmid":1,"scopus_import":"1","isi":1,"date_created":"2019-03-31T21:59:13Z","abstract":[{"text":"The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics with morphogen turnover and transport to explore routes to patterning. Our active description couples morphogen reaction and diffusion, which impact cell differentiation and tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase consists of a poroelastic cell network and the other one of a permeating extracellular fluid, which provides a feedback by actively transporting morphogens. While this model encompasses previous theories approximating tissues to inert monophasic media, such as Turing’s reaction–diffusion model, it overcomes some of their key limitations permitting pattern formation via any two-species biochemical kinetics due to mechanically induced cross-diffusion flows. Moreover, we describe a qualitatively different advection-driven Keller–Segel instability which allows for the formation of patterns with a single morphogen and whose fundamental mode pattern robustly scales with tissue size. We discuss the potential relevance of these findings for tissue morphogenesis.","lang":"eng"}],"day":"19","language":[{"iso":"eng"}],"related_material":{"link":[{"url":"www.pnas.org/lookup/suppl/doi:10.1073/pnas.1813255116/-/DCSupplemental","relation":"supplementary_material"}]},"title":"Theory of mechanochemical patterning in biphasic biological tissues","volume":116,"file_date_updated":"2020-07-14T12:47:23Z"},{"related_material":{"link":[{"url":"https://ist.ac.at/en/news/body-height-bmi-disease-risk-co/","description":"News on IST Homepage","relation":"press_release"}]},"language":[{"iso":"eng"}],"title":"Why structure matters","volume":8,"file_date_updated":"2020-07-14T12:47:24Z","date_created":"2019-04-07T21:59:15Z","day":"21","abstract":[{"text":"Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies.","lang":"eng"}],"scopus_import":"1","isi":1,"quality_controlled":"1","author":[{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240"},{"last_name":"Hermisson","full_name":"Hermisson, Joachim","first_name":"Joachim"},{"last_name":"Nordborg","first_name":"Magnus","full_name":"Nordborg, Magnus"}],"_id":"6230","doi":"10.7554/eLife.45380","type":"journal_article","publication":"eLife","external_id":{"isi":["000461988300001"]},"ddc":["570"],"citation":{"ieee":"N. H. Barton, J. Hermisson, and M. Nordborg, “Why structure matters,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","mla":"Barton, Nicholas H., et al. “Why Structure Matters.” <i>ELife</i>, vol. 8, e45380, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>.","apa":"Barton, N. H., Hermisson, J., &#38; Nordborg, M. (2019). Why structure matters. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>","ama":"Barton NH, Hermisson J, Nordborg M. Why structure matters. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>","ista":"Barton NH, Hermisson J, Nordborg M. 2019. Why structure matters. eLife. 8, e45380.","chicago":"Barton, Nicholas H, Joachim Hermisson, and Magnus Nordborg. “Why Structure Matters.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>.","short":"N.H. Barton, J. Hermisson, M. Nordborg, ELife 8 (2019)."},"intvolume":"         8","oa":1,"article_processing_charge":"No","article_number":"e45380","department":[{"_id":"NiBa"}],"publication_status":"published","date_updated":"2026-04-02T14:03:15Z","date_published":"2019-03-21T00:00:00Z","month":"03","publisher":"eLife Sciences Publications","year":"2019","status":"public","has_accepted_license":"1","publication_identifier":{"eissn":["2050-084X"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa_version":"Published Version","file":[{"date_created":"2019-04-11T11:43:38Z","file_name":"2019_eLife_Barton.pdf","relation":"main_file","file_id":"6293","access_level":"open_access","content_type":"application/pdf","file_size":298466,"checksum":"130d7544b57df4a6787e1263c2d7ea43","creator":"dernst","date_updated":"2020-07-14T12:47:24Z"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"}},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0091-1798"]},"oa_version":"Preprint","issue":"2","year":"2019","status":"public","publication_status":"published","date_updated":"2025-07-10T11:53:17Z","month":"03","date_published":"2019-03-01T00:00:00Z","publisher":"Institute of Mathematical Statistics","oa":1,"department":[{"_id":"JaMa"}],"article_processing_charge":"No","type":"journal_article","publication":"Annals of Probability","intvolume":"        47","arxiv":1,"external_id":{"arxiv":["1705.05364"],"isi":["000459681900005"]},"citation":{"ama":"Gerencser M. Boundary regularity of stochastic PDEs. <i>Annals of Probability</i>. 2019;47(2):804-834. doi:<a href=\"https://doi.org/10.1214/18-AOP1272\">10.1214/18-AOP1272</a>","apa":"Gerencser, M. (2019). Boundary regularity of stochastic PDEs. <i>Annals of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/18-AOP1272\">https://doi.org/10.1214/18-AOP1272</a>","ieee":"M. Gerencser, “Boundary regularity of stochastic PDEs,” <i>Annals of Probability</i>, vol. 47, no. 2. Institute of Mathematical Statistics, pp. 804–834, 2019.","mla":"Gerencser, Mate. “Boundary Regularity of Stochastic PDEs.” <i>Annals of Probability</i>, vol. 47, no. 2, Institute of Mathematical Statistics, 2019, pp. 804–34, doi:<a href=\"https://doi.org/10.1214/18-AOP1272\">10.1214/18-AOP1272</a>.","short":"M. Gerencser, Annals of Probability 47 (2019) 804–834.","chicago":"Gerencser, Mate. “Boundary Regularity of Stochastic PDEs.” <i>Annals of Probability</i>. Institute of Mathematical Statistics, 2019. <a href=\"https://doi.org/10.1214/18-AOP1272\">https://doi.org/10.1214/18-AOP1272</a>.","ista":"Gerencser M. 2019. Boundary regularity of stochastic PDEs. Annals of Probability. 47(2), 804–834."},"page":"804-834","author":[{"last_name":"Gerencser","id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","first_name":"Mate","full_name":"Gerencser, Mate"}],"quality_controlled":"1","_id":"6232","doi":"10.1214/18-AOP1272","isi":1,"scopus_import":"1","volume":47,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1705.05364"}],"language":[{"iso":"eng"}],"title":"Boundary regularity of stochastic PDEs","date_created":"2019-04-07T21:59:15Z","day":"01","abstract":[{"lang":"eng","text":"The boundary behaviour of solutions of stochastic PDEs with Dirichlet boundary conditions can be surprisingly—and in a sense, arbitrarily—bad: as shown by Krylov[ SIAM J. Math. Anal.34(2003) 1167–1182], for any α>0 one can find a simple 1-dimensional constant coefficient linear equation whose solution at the boundary is not α-Hölder continuous.We obtain a positive counterpart of this: under some mild regularity assumptions on the coefficients, solutions of semilinear SPDEs on C1 domains are proved to be α-Hölder continuous up to the boundary with some α>0."}]},{"type":"journal_article","publication":"Annales de l'institut Henri Poincare","arxiv":1,"intvolume":"        55","citation":{"ieee":"J. Alt, L. Erdös, T. H. Krüger, and Y. Nemish, “Location of the spectrum of Kronecker random matrices,” <i>Annales de l’institut Henri Poincare</i>, vol. 55, no. 2. Institut Henri Poincaré, pp. 661–696, 2019.","mla":"Alt, Johannes, et al. “Location of the Spectrum of Kronecker Random Matrices.” <i>Annales de l’institut Henri Poincare</i>, vol. 55, no. 2, Institut Henri Poincaré, 2019, pp. 661–96, doi:<a href=\"https://doi.org/10.1214/18-AIHP894\">10.1214/18-AIHP894</a>.","ama":"Alt J, Erdös L, Krüger TH, Nemish Y. Location of the spectrum of Kronecker random matrices. <i>Annales de l’institut Henri Poincare</i>. 2019;55(2):661-696. doi:<a href=\"https://doi.org/10.1214/18-AIHP894\">10.1214/18-AIHP894</a>","apa":"Alt, J., Erdös, L., Krüger, T. H., &#38; Nemish, Y. (2019). Location of the spectrum of Kronecker random matrices. <i>Annales de l’institut Henri Poincare</i>. Institut Henri Poincaré. <a href=\"https://doi.org/10.1214/18-AIHP894\">https://doi.org/10.1214/18-AIHP894</a>","ista":"Alt J, Erdös L, Krüger TH, Nemish Y. 2019. Location of the spectrum of Kronecker random matrices. Annales de l’institut Henri Poincare. 55(2), 661–696.","short":"J. Alt, L. Erdös, T.H. Krüger, Y. Nemish, Annales de l’institut Henri Poincare 55 (2019) 661–696.","chicago":"Alt, Johannes, László Erdös, Torben H Krüger, and Yuriy Nemish. “Location of the Spectrum of Kronecker Random Matrices.” <i>Annales de l’institut Henri Poincare</i>. Institut Henri Poincaré, 2019. <a href=\"https://doi.org/10.1214/18-AIHP894\">https://doi.org/10.1214/18-AIHP894</a>."},"external_id":{"arxiv":["1706.08343"],"isi":["000467793600003"]},"author":[{"first_name":"Johannes","full_name":"Alt, Johannes","id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","last_name":"Alt"},{"full_name":"Erdös, László","first_name":"László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"first_name":"Torben H","full_name":"Krüger, Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-4821-3297","last_name":"Krüger"},{"orcid":"0000-0002-7327-856X","last_name":"Nemish","full_name":"Nemish, Yuriy","first_name":"Yuriy","id":"4D902E6A-F248-11E8-B48F-1D18A9856A87"}],"page":"661-696","quality_controlled":"1","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804"}],"doi":"10.1214/18-AIHP894","_id":"6240","isi":1,"scopus_import":"1","volume":55,"title":"Location of the spectrum of Kronecker random matrices","language":[{"iso":"eng"}],"related_material":{"record":[{"status":"public","id":"149","relation":"dissertation_contains"}]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1706.08343"}],"abstract":[{"text":"For a general class of large non-Hermitian random block matrices X we prove that there are no eigenvalues away from a deterministic set with very high probability. This set is obtained from the Dyson equation of the Hermitization of X as the self-consistent approximation of the pseudospectrum. We demonstrate that the analysis of the matrix Dyson equation from (Probab. Theory Related Fields (2018)) offers a unified treatment of many structured matrix ensembles.","lang":"eng"}],"day":"01","date_created":"2019-04-08T14:05:04Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0246-0203"]},"oa_version":"Preprint","year":"2019","issue":"2","status":"public","month":"05","date_published":"2019-05-01T00:00:00Z","publication_status":"published","date_updated":"2026-04-08T14:11:36Z","ec_funded":1,"publisher":"Institut Henri Poincaré","oa":1,"department":[{"_id":"LaEr"}],"article_processing_charge":"No"},{"ec_funded":1,"publisher":"Springer Nature","publication_status":"published","date_updated":"2025-04-14T07:45:04Z","month":"04","article_type":"original","date_published":"2019-04-11T00:00:00Z","department":[{"_id":"JiFr"}],"article_processing_charge":"No","oa":1,"oa_version":"Submitted Version","file":[{"date_updated":"2020-11-13T07:37:41Z","checksum":"6b84ab602a34382cf0340a37a1378c75","access_level":"open_access","file_size":4321328,"content_type":"application/pdf","creator":"dernst","success":1,"file_id":"8751","date_created":"2020-11-13T07:37:41Z","file_name":"2019_Nature _Cao_accepted.pdf","relation":"main_file"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"has_accepted_license":"1","year":"2019","status":"public","pmid":1,"isi":1,"scopus_import":"1","date_created":"2019-04-09T08:37:05Z","day":"11","abstract":[{"lang":"eng","text":"The plant hormone auxin has crucial roles in almost all aspects of plant growth and development. Concentrations of auxin vary across different tissues, mediating distinct developmental outcomes and contributing to the functional diversity of auxin. However, the mechanisms that underlie these activities are poorly understood. Here we identify an auxin signalling mechanism, which acts in parallel to the canonical auxin pathway based on the transport inhibitor response1 (TIR1) and other auxin receptor F-box (AFB) family proteins (TIR1/AFB receptors)1,2, that translates levels of cellular auxin to mediate differential growth during apical-hook development. This signalling mechanism operates at the concave side of the apical hook, and involves auxin-mediated C-terminal cleavage of transmembrane kinase 1 (TMK1). The cytosolic and nucleus-translocated C terminus of TMK1 specifically interacts with and phosphorylates two non-canonical transcriptional repressors of the auxin or indole-3-acetic acid (Aux/IAA) family (IAA32 and IAA34), thereby regulating ARF transcription factors. In contrast to the degradation of Aux/IAA transcriptional repressors in the canonical pathway, the newly identified mechanism stabilizes the non-canonical IAA32 and IAA34 transcriptional repressors to regulate gene expression and ultimately inhibit growth. The auxin–TMK1 signalling pathway originates at the cell surface, is triggered by high levels of auxin and shares a partially overlapping set of transcription factors with the TIR1/AFB signalling pathway. This allows distinct interpretations of different concentrations of cellular auxin, and thus enables this versatile signalling molecule to mediate complex developmental outcomes."}],"volume":568,"file_date_updated":"2020-11-13T07:37:41Z","related_material":{"link":[{"url":"https://ist.ac.at/en/news/newly-discovered-mechanism-of-plant-hormone-auxin-acts-the-opposite-way/","description":"News on IST Homepage","relation":"press_release"}]},"language":[{"iso":"eng"}],"title":"TMK1-mediated auxin signalling regulates differential growth of the apical hook","intvolume":"       568","external_id":{"pmid":["30944466"],"isi":["000464412700050"]},"ddc":["580"],"citation":{"ama":"Cao M, Chen R, Li P, et al. TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. 2019;568:240-243. doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>","apa":"Cao, M., Chen, R., Li, P., Yu, Y., Zheng, R., Ge, D., … Xu, T. (2019). TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>","ieee":"M. Cao <i>et al.</i>, “TMK1-mediated auxin signalling regulates differential growth of the apical hook,” <i>Nature</i>, vol. 568. Springer Nature, pp. 240–243, 2019.","mla":"Cao, Min, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>, vol. 568, Springer Nature, 2019, pp. 240–43, doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>.","short":"M. Cao, R. Chen, P. Li, Y. Yu, R. Zheng, D. Ge, W. Zheng, X. Wang, Y. Gu, Z. Gelová, J. Friml, H. Zhang, R. Liu, J. He, T. Xu, Nature 568 (2019) 240–243.","chicago":"Cao, Min, Rong Chen, Pan Li, Yongqiang Yu, Rui Zheng, Danfeng Ge, Wei Zheng, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>.","ista":"Cao M, Chen R, Li P, Yu Y, Zheng R, Ge D, Zheng W, Wang X, Gu Y, Gelová Z, Friml J, Zhang H, Liu R, He J, Xu T. 2019. TMK1-mediated auxin signalling regulates differential growth of the apical hook. Nature. 568, 240–243."},"type":"journal_article","publication":"Nature","project":[{"grant_number":"742985","call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425"}],"_id":"6259","doi":"10.1038/s41586-019-1069-7","page":"240-243","author":[{"full_name":"Cao, Min","first_name":"Min","last_name":"Cao"},{"full_name":"Chen, Rong","first_name":"Rong","last_name":"Chen"},{"full_name":"Li, Pan","first_name":"Pan","last_name":"Li"},{"last_name":"Yu","full_name":"Yu, Yongqiang","first_name":"Yongqiang"},{"full_name":"Zheng, Rui","first_name":"Rui","last_name":"Zheng"},{"full_name":"Ge, Danfeng","first_name":"Danfeng","last_name":"Ge"},{"first_name":"Wei","full_name":"Zheng, Wei","last_name":"Zheng"},{"first_name":"Xuhui","full_name":"Wang, Xuhui","last_name":"Wang"},{"last_name":"Gu","full_name":"Gu, Yangtao","first_name":"Yangtao"},{"last_name":"Gelová","orcid":"0000-0003-4783-1752","id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","first_name":"Zuzana","full_name":"Gelová, Zuzana"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří"},{"last_name":"Zhang","first_name":"Heng","full_name":"Zhang, Heng"},{"last_name":"Liu","full_name":"Liu, Renyi","first_name":"Renyi"},{"last_name":"He","full_name":"He, Jun","first_name":"Jun"},{"first_name":"Tongda","full_name":"Xu, Tongda","last_name":"Xu"}],"quality_controlled":"1"},{"main_file_link":[{"url":"https://doi.org/10.1104/pp.18.01305","open_access":"1"}],"language":[{"iso":"eng"}],"title":"Nitrate modulates the differentiation of root distal stem cells","volume":180,"date_created":"2019-04-09T08:46:17Z","day":"01","abstract":[{"text":"Nitrate regulation of root stem cell activity is auxin-dependent.","lang":"eng"}],"scopus_import":"1","isi":1,"pmid":1,"quality_controlled":"1","page":"22-25","author":[{"full_name":"Wang, Y","first_name":"Y","last_name":"Wang"},{"last_name":"Gong","first_name":"Z","full_name":"Gong, Z"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Zhang","full_name":"Zhang, J","first_name":"J"}],"_id":"6261","doi":"10.1104/pp.18.01305","type":"journal_article","publication":"Plant Physiology","ddc":["580"],"external_id":{"pmid":["30787134"],"isi":["000466860800010"]},"citation":{"ista":"Wang Y, Gong Z, Friml J, Zhang J. 2019. Nitrate modulates the differentiation of root distal stem cells. Plant Physiology. 180(1), 22–25.","short":"Y. Wang, Z. Gong, J. Friml, J. Zhang, Plant Physiology 180 (2019) 22–25.","chicago":"Wang, Y, Z Gong, Jiří Friml, and J Zhang. “Nitrate Modulates the Differentiation of Root Distal Stem Cells.” <i>Plant Physiology</i>. ASPB, 2019. <a href=\"https://doi.org/10.1104/pp.18.01305\">https://doi.org/10.1104/pp.18.01305</a>.","ieee":"Y. Wang, Z. Gong, J. Friml, and J. Zhang, “Nitrate modulates the differentiation of root distal stem cells,” <i>Plant Physiology</i>, vol. 180, no. 1. ASPB, pp. 22–25, 2019.","mla":"Wang, Y., et al. “Nitrate Modulates the Differentiation of Root Distal Stem Cells.” <i>Plant Physiology</i>, vol. 180, no. 1, ASPB, 2019, pp. 22–25, doi:<a href=\"https://doi.org/10.1104/pp.18.01305\">10.1104/pp.18.01305</a>.","ama":"Wang Y, Gong Z, Friml J, Zhang J. Nitrate modulates the differentiation of root distal stem cells. <i>Plant Physiology</i>. 2019;180(1):22-25. doi:<a href=\"https://doi.org/10.1104/pp.18.01305\">10.1104/pp.18.01305</a>","apa":"Wang, Y., Gong, Z., Friml, J., &#38; Zhang, J. (2019). Nitrate modulates the differentiation of root distal stem cells. <i>Plant Physiology</i>. ASPB. <a href=\"https://doi.org/10.1104/pp.18.01305\">https://doi.org/10.1104/pp.18.01305</a>"},"intvolume":"       180","oa":1,"article_processing_charge":"No","department":[{"_id":"JiFr"}],"date_updated":"2026-06-18T19:02:50Z","publication_status":"published","article_type":"letter_note","date_published":"2019-05-01T00:00:00Z","month":"05","publisher":"ASPB","year":"2019","status":"public","issue":"1","publication_identifier":{"eissn":["1532-2548"],"issn":["0032-0889"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version"}]