[{"status":"public","year":"2019","degree_awarded":"PhD","has_accepted_license":"1","corr_author":"1","publication_identifier":{"issn":["2663-337X"]},"OA_place":"publisher","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa_version":"Published Version","file":[{"relation":"source_file","file_name":"2019_Schroeder_Thesis.tar.gz","date_created":"2019-03-28T08:53:52Z","file_id":"6180","creator":"dernst","checksum":"6926f66f28079a81c4937e3764be00fc","access_level":"closed","content_type":"application/x-gzip","file_size":7104482,"date_updated":"2020-07-14T12:47:21Z"},{"file_id":"6181","date_created":"2019-03-28T08:53:52Z","file_name":"2019_Schroeder_Thesis.pdf","relation":"main_file","date_updated":"2020-07-14T12:47:21Z","content_type":"application/pdf","access_level":"open_access","file_size":4228794,"checksum":"7d0ebb8d1207e89768cdd497a5bf80fb","creator":"dernst"}],"alternative_title":["ISTA Thesis"],"oa":1,"article_processing_charge":"No","department":[{"_id":"LaEr"}],"publication_status":"published","date_updated":"2026-04-08T13:55:03Z","date_published":"2019-03-18T00:00:00Z","month":"03","publisher":"Institute of Science and Technology Austria","ec_funded":1,"author":[{"full_name":"Schröder, Dominik J","first_name":"Dominik J","id":"408ED176-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2904-1856","last_name":"Schröder"}],"page":"375","_id":"6179","doi":"10.15479/AT:ISTA:th6179","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"338804","name":"Random matrices, universality and disordered quantum systems"}],"type":"dissertation","ddc":["515","519"],"citation":{"ama":"Schröder DJ. From Dyson to Pearcey: Universal statistics in random matrix theory. 2019. doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">10.15479/AT:ISTA:th6179</a>","apa":"Schröder, D. J. (2019). <i>From Dyson to Pearcey: Universal statistics in random matrix theory</i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">https://doi.org/10.15479/AT:ISTA:th6179</a>","mla":"Schröder, Dominik J. <i>From Dyson to Pearcey: Universal Statistics in Random Matrix Theory</i>. Institute of Science and Technology Austria, 2019, doi:<a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">10.15479/AT:ISTA:th6179</a>.","ieee":"D. J. Schröder, “From Dyson to Pearcey: Universal statistics in random matrix theory,” Institute of Science and Technology Austria, 2019.","short":"D.J. Schröder, From Dyson to Pearcey: Universal Statistics in Random Matrix Theory, Institute of Science and Technology Austria, 2019.","chicago":"Schröder, Dominik J. “From Dyson to Pearcey: Universal Statistics in Random Matrix Theory.” Institute of Science and Technology Austria, 2019. <a href=\"https://doi.org/10.15479/AT:ISTA:th6179\">https://doi.org/10.15479/AT:ISTA:th6179</a>.","ista":"Schröder DJ. 2019. From Dyson to Pearcey: Universal statistics in random matrix theory. Institute of Science and Technology Austria."},"related_material":{"record":[{"status":"public","relation":"part_of_dissertation","id":"6184"},{"status":"public","relation":"part_of_dissertation","id":"6186"},{"status":"public","relation":"part_of_dissertation","id":"6185"},{"status":"public","relation":"part_of_dissertation","id":"1012"},{"relation":"part_of_dissertation","id":"1144","status":"public"},{"relation":"part_of_dissertation","id":"6182","status":"public"}]},"language":[{"iso":"eng"}],"title":"From Dyson to Pearcey: Universal statistics in random matrix theory","file_date_updated":"2020-07-14T12:47:21Z","date_created":"2019-03-28T08:58:59Z","abstract":[{"lang":"eng","text":"In the first part of this thesis we consider large random matrices with arbitrary expectation and a general slowly decaying correlation among its entries. We prove universality of the local eigenvalue statistics and optimal local laws for the resolvent in the bulk and edge regime. The main novel tool is a systematic diagrammatic control of a multivariate cumulant expansion.\r\nIn the second part we consider Wigner-type matrices and show that at any cusp singularity of the limiting eigenvalue distribution the local eigenvalue statistics are uni- versal and form a Pearcey process. Since the density of states typically exhibits only square root or cubic root cusp singularities, our work complements previous results on the bulk and edge universality and it thus completes the resolution of the Wigner- Dyson-Mehta universality conjecture for the last remaining universality type. Our analysis holds not only for exact cusps, but approximate cusps as well, where an ex- tended Pearcey process emerges. As a main technical ingredient we prove an optimal local law at the cusp, and extend the fast relaxation to equilibrium of the Dyson Brow- nian motion to the cusp regime.\r\nIn the third and final part we explore the entrywise linear statistics of Wigner ma- trices and identify the fluctuations for a large class of test functions with little regularity. This enables us to study the rectangular Young diagram obtained from the interlacing eigenvalues of the random matrix and its minor, and we find that, despite having the same limit, the fluctuations differ from those of the algebraic Young tableaux equipped with the Plancharel measure."}],"day":"18","supervisor":[{"last_name":"Erdös","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","first_name":"László"}]},{"year":"2019","status":"public","corr_author":"1","has_accepted_license":"1","publication_identifier":{"eissn":["2050-5094"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","file":[{"date_updated":"2020-07-14T12:47:22Z","access_level":"open_access","file_size":1520344,"checksum":"933a472568221c73b2c3ce8c87bf6d15","content_type":"application/pdf","creator":"dernst","file_id":"6883","date_created":"2019-09-17T14:24:13Z","file_name":"2019_Forum_Erdoes.pdf","relation":"main_file"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa":1,"article_processing_charge":"No","article_number":"e8","department":[{"_id":"LaEr"}],"month":"03","article_type":"original","date_published":"2019-03-26T00:00:00Z","date_updated":"2026-04-08T13:55:03Z","publication_status":"published","publisher":"Cambridge University Press","ec_funded":1,"quality_controlled":"1","author":[{"orcid":"0000-0001-5366-9603","last_name":"Erdös","first_name":"László","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-4821-3297","last_name":"Krüger","full_name":"Krüger, Torben H","first_name":"Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schröder","orcid":"0000-0002-2904-1856","id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J","full_name":"Schröder, Dominik J"}],"doi":"10.1017/fms.2019.2","_id":"6182","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","grant_number":"338804","call_identifier":"FP7","name":"Random matrices, universality and disordered quantum systems"}],"publication":"Forum of Mathematics, Sigma","type":"journal_article","citation":{"short":"L. Erdös, T.H. Krüger, D.J. Schröder, Forum of Mathematics, Sigma 7 (2019).","chicago":"Erdös, László, Torben H Krüger, and Dominik J Schröder. “Random Matrices with Slow Correlation Decay.” <i>Forum of Mathematics, Sigma</i>. Cambridge University Press, 2019. <a href=\"https://doi.org/10.1017/fms.2019.2\">https://doi.org/10.1017/fms.2019.2</a>.","ista":"Erdös L, Krüger TH, Schröder DJ. 2019. Random matrices with slow correlation decay. Forum of Mathematics, Sigma. 7, e8.","ama":"Erdös L, Krüger TH, Schröder DJ. Random matrices with slow correlation decay. <i>Forum of Mathematics, Sigma</i>. 2019;7. doi:<a href=\"https://doi.org/10.1017/fms.2019.2\">10.1017/fms.2019.2</a>","apa":"Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2019). Random matrices with slow correlation decay. <i>Forum of Mathematics, Sigma</i>. Cambridge University Press. <a href=\"https://doi.org/10.1017/fms.2019.2\">https://doi.org/10.1017/fms.2019.2</a>","ieee":"L. Erdös, T. H. Krüger, and D. J. Schröder, “Random matrices with slow correlation decay,” <i>Forum of Mathematics, Sigma</i>, vol. 7. Cambridge University Press, 2019.","mla":"Erdös, László, et al. “Random Matrices with Slow Correlation Decay.” <i>Forum of Mathematics, Sigma</i>, vol. 7, e8, Cambridge University Press, 2019, doi:<a href=\"https://doi.org/10.1017/fms.2019.2\">10.1017/fms.2019.2</a>."},"ddc":["510"],"external_id":{"arxiv":["1705.10661"],"isi":["000488847100001"]},"arxiv":1,"intvolume":"         7","title":"Random matrices with slow correlation decay","related_material":{"record":[{"status":"public","id":"6179","relation":"dissertation_contains"}]},"language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:22Z","volume":7,"abstract":[{"lang":"eng","text":"We consider large random matrices with a general slowly decaying correlation among its entries. We prove universality of the local eigenvalue statistics and optimal local laws for the resolvent away from the spectral edges, generalizing the recent result of Ajanki et al. [‘Stability of the matrix Dyson equation and random matrices with correlations’, Probab. Theory Related Fields 173(1–2) (2019), 293–373] to allow slow correlation decay and arbitrary expectation. The main novel tool is\r\na systematic diagrammatic control of a multivariate cumulant expansion."}],"day":"26","date_created":"2019-03-28T09:05:23Z","scopus_import":"1","isi":1},{"day":"12","abstract":[{"text":"We prove that the local eigenvalue statistics of real symmetric Wigner-type\r\nmatrices near the cusp points of the eigenvalue density are universal. Together\r\nwith the companion paper [arXiv:1809.03971], which proves the same result for\r\nthe complex Hermitian symmetry class, this completes the last remaining case of\r\nthe Wigner-Dyson-Mehta universality conjecture after bulk and edge\r\nuniversalities have been established in the last years. We extend the recent\r\nDyson Brownian motion analysis at the edge [arXiv:1712.03881] to the cusp\r\nregime using the optimal local law from [arXiv:1809.03971] and the accurate\r\nlocal shape analysis of the density from [arXiv:1506.05095, arXiv:1804.07752].\r\nWe also present a PDE-based method to improve the estimate on eigenvalue\r\nrigidity via the maximum principle of the heat flow related to the Dyson\r\nBrownian motion.","lang":"eng"}],"date_created":"2019-03-28T10:21:17Z","volume":1,"title":"Cusp universality for random matrices, II: The real symmetric case","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"6179","relation":"dissertation_contains","status":"public"}]},"main_file_link":[{"url":"https://arxiv.org/abs/1811.04055","open_access":"1"}],"scopus_import":"1","project":[{"name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425"},{"call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"doi":"10.2140/paa.2019.1.615","_id":"6186","page":"615–707","author":[{"orcid":"0000-0002-4901-7992","last_name":"Cipolloni","first_name":"Giorgio","full_name":"Cipolloni, Giorgio","id":"42198EFA-F248-11E8-B48F-1D18A9856A87"},{"first_name":"László","full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","last_name":"Erdös"},{"last_name":"Krüger","orcid":"0000-0002-4821-3297","id":"3020C786-F248-11E8-B48F-1D18A9856A87","first_name":"Torben H","full_name":"Krüger, Torben H"},{"id":"408ED176-F248-11E8-B48F-1D18A9856A87","first_name":"Dominik J","full_name":"Schröder, Dominik J","last_name":"Schröder","orcid":"0000-0002-2904-1856"}],"quality_controlled":"1","arxiv":1,"intvolume":"         1","citation":{"ista":"Cipolloni G, Erdös L, Krüger TH, Schröder DJ. 2019. Cusp universality for random matrices, II: The real symmetric case. Pure and Applied Analysis . 1(4), 615–707.","chicago":"Cipolloni, Giorgio, László Erdös, Torben H Krüger, and Dominik J Schröder. “Cusp Universality for Random Matrices, II: The Real Symmetric Case.” <i>Pure and Applied Analysis </i>. MSP, 2019. <a href=\"https://doi.org/10.2140/paa.2019.1.615\">https://doi.org/10.2140/paa.2019.1.615</a>.","short":"G. Cipolloni, L. Erdös, T.H. Krüger, D.J. Schröder, Pure and Applied Analysis  1 (2019) 615–707.","mla":"Cipolloni, Giorgio, et al. “Cusp Universality for Random Matrices, II: The Real Symmetric Case.” <i>Pure and Applied Analysis </i>, vol. 1, no. 4, MSP, 2019, pp. 615–707, doi:<a href=\"https://doi.org/10.2140/paa.2019.1.615\">10.2140/paa.2019.1.615</a>.","ieee":"G. Cipolloni, L. Erdös, T. H. Krüger, and D. J. Schröder, “Cusp universality for random matrices, II: The real symmetric case,” <i>Pure and Applied Analysis </i>, vol. 1, no. 4. MSP, pp. 615–707, 2019.","apa":"Cipolloni, G., Erdös, L., Krüger, T. H., &#38; Schröder, D. J. (2019). Cusp universality for random matrices, II: The real symmetric case. <i>Pure and Applied Analysis </i>. MSP. <a href=\"https://doi.org/10.2140/paa.2019.1.615\">https://doi.org/10.2140/paa.2019.1.615</a>","ama":"Cipolloni G, Erdös L, Krüger TH, Schröder DJ. Cusp universality for random matrices, II: The real symmetric case. <i>Pure and Applied Analysis </i>. 2019;1(4):615–707. doi:<a href=\"https://doi.org/10.2140/paa.2019.1.615\">10.2140/paa.2019.1.615</a>"},"external_id":{"arxiv":["1811.04055"]},"type":"journal_article","publication":"Pure and Applied Analysis ","department":[{"_id":"LaEr"}],"article_processing_charge":"No","oa":1,"ec_funded":1,"publisher":"MSP","article_type":"original","month":"10","date_published":"2019-10-12T00:00:00Z","publication_status":"published","date_updated":"2026-04-08T13:55:02Z","issue":"4","year":"2019","status":"public","oa_version":"Preprint","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["2578-5885"],"issn":["2578-5893"]}},{"pmid":1,"isi":1,"scopus_import":"1","abstract":[{"lang":"eng","text":"Increased levels of the chemokine CCL2 in cancer patients are associated with poor prognosis. Experimental evidence suggests that CCL2 correlates with inflammatory monocyte recruitment and induction of vascular activation, but the functionality remains open. Here, we show that endothelial Ccr2 facilitates pulmonary metastasis using an endothelial-specific Ccr2-deficient mouse model (Ccr2ecKO). Similar levels of circulating monocytes and equal leukocyte recruitment to metastatic lesions of Ccr2ecKO and Ccr2fl/fl littermates were observed. The absence of endothelial Ccr2 strongly reduced pulmonary metastasis, while the primary tumor growth was unaffected. Despite a comparable cytokine milieu in Ccr2ecKO and Ccr2fl/fl littermates the absence of vascular permeability induction was observed only in Ccr2ecKO mice. CCL2 stimulation of pulmonary endothelial cells resulted in increased phosphorylation of MLC2, endothelial cell retraction, and vascular leakiness that was blocked by an addition of a CCR2 inhibitor. These data demonstrate that endothelial CCR2 expression is required for tumor cell extravasation and pulmonary metastasis.\r\n\r\nImplications: The findings provide mechanistic insight into how CCL2–CCR2 signaling in endothelial cells promotes their activation through myosin light chain phosphorylation, resulting in endothelial retraction and enhanced tumor cell migration and metastasis."}],"day":"01","date_created":"2019-03-31T21:59:12Z","volume":17,"title":"CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis","main_file_link":[{"url":"https://doi.org/10.1158/1541-7786.MCR-18-0530","open_access":"1"}],"language":[{"iso":"eng"}],"intvolume":"        17","citation":{"ista":"Roblek M, Protsyuk D, Becker PF, Stefanescu C, Gorzelanny C, Glaus Garzon JF, Knopfova L, Heikenwalder M, Luckow B, Schneider SW, Borsig L. 2019. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. Molecular Cancer Research. 17(3), 783–793.","short":"M. Roblek, D. Protsyuk, P.F. Becker, C. Stefanescu, C. Gorzelanny, J.F. Glaus Garzon, L. Knopfova, M. Heikenwalder, B. Luckow, S.W. Schneider, L. Borsig, Molecular Cancer Research 17 (2019) 783–793.","chicago":"Roblek, Marko, Darya Protsyuk, Paul F. Becker, Cristina Stefanescu, Christian Gorzelanny, Jesus F. Glaus Garzon, Lucia Knopfova, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>. AACR, 2019. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>.","ieee":"M. Roblek <i>et al.</i>, “CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis,” <i>Molecular Cancer Research</i>, vol. 17, no. 3. AACR, pp. 783–793, 2019.","mla":"Roblek, Marko, et al. “CCL2 Is a Vascular Permeability Factor Inducing CCR2-Dependent Endothelial Retraction during Lung Metastasis.” <i>Molecular Cancer Research</i>, vol. 17, no. 3, AACR, 2019, pp. 783–93, doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>.","ama":"Roblek M, Protsyuk D, Becker PF, et al. CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. 2019;17(3):783-793. doi:<a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">10.1158/1541-7786.MCR-18-0530</a>","apa":"Roblek, M., Protsyuk, D., Becker, P. F., Stefanescu, C., Gorzelanny, C., Glaus Garzon, J. F., … Borsig, L. (2019). CCL2 is a vascular permeability factor inducing CCR2-dependent endothelial retraction during lung metastasis. <i>Molecular Cancer Research</i>. AACR. <a href=\"https://doi.org/10.1158/1541-7786.MCR-18-0530\">https://doi.org/10.1158/1541-7786.MCR-18-0530</a>"},"ddc":["570"],"external_id":{"isi":["000460099800012"],"pmid":["30552233"]},"publication":"Molecular Cancer Research","type":"journal_article","doi":"10.1158/1541-7786.MCR-18-0530","_id":"6190","author":[{"orcid":"0000-0001-9588-1389","last_name":"Roblek","full_name":"Roblek, Marko","first_name":"Marko","id":"3047D808-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Protsyuk","first_name":"Darya","full_name":"Protsyuk, Darya"},{"full_name":"Becker, Paul F.","first_name":"Paul F.","last_name":"Becker"},{"last_name":"Stefanescu","full_name":"Stefanescu, Cristina","first_name":"Cristina"},{"first_name":"Christian","full_name":"Gorzelanny, Christian","last_name":"Gorzelanny"},{"last_name":"Glaus Garzon","full_name":"Glaus Garzon, Jesus F.","first_name":"Jesus F."},{"last_name":"Knopfova","first_name":"Lucia","full_name":"Knopfova, Lucia"},{"first_name":"Mathias","full_name":"Heikenwalder, Mathias","last_name":"Heikenwalder"},{"last_name":"Luckow","full_name":"Luckow, Bruno","first_name":"Bruno"},{"last_name":"Schneider","first_name":"Stefan W.","full_name":"Schneider, Stefan W."},{"first_name":"Lubor","full_name":"Borsig, Lubor","last_name":"Borsig"}],"page":"783-793","quality_controlled":"1","publisher":"AACR","date_published":"2019-03-01T00:00:00Z","article_type":"original","month":"03","date_updated":"2026-06-18T19:00:54Z","publication_status":"published","department":[{"_id":"DaSi"}],"article_processing_charge":"No","oa":1,"oa_version":"Published Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["1541-7786"],"eissn":["1557-3125"]},"issue":"3","status":"public","year":"2019"},{"author":[{"last_name":"Recho","first_name":"Pierre","full_name":"Recho, Pierre"},{"full_name":"Hallou, Adrien","first_name":"Adrien","last_name":"Hallou"},{"full_name":"Hannezo, Edouard B","first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561","last_name":"Hannezo"}],"page":"5344-5349","quality_controlled":"1","project":[{"name":"Active mechano-chemical description of the cell cytoskeleton","grant_number":"P31639","call_identifier":"FWF","_id":"268294B6-B435-11E9-9278-68D0E5697425"}],"_id":"6191","doi":"10.1073/pnas.1813255116","type":"journal_article","publication":"Proceedings of the National Academy of Sciences of the United States of America","intvolume":"       116","external_id":{"isi":["000461679000027"],"pmid":["30819884"]},"ddc":["570"],"citation":{"ista":"Recho P, Hallou A, Hannezo EB. 2019. Theory of mechanochemical patterning in biphasic biological tissues. Proceedings of the National Academy of Sciences of the United States of America. 116(12), 5344–5349.","short":"P. Recho, A. Hallou, E.B. Hannezo, Proceedings of the National Academy of Sciences of the United States of America 116 (2019) 5344–5349.","chicago":"Recho, Pierre, Adrien Hallou, and Edouard B Hannezo. “Theory of Mechanochemical Patterning in Biphasic Biological Tissues.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2019. <a href=\"https://doi.org/10.1073/pnas.1813255116\">https://doi.org/10.1073/pnas.1813255116</a>.","ieee":"P. Recho, A. Hallou, and E. B. Hannezo, “Theory of mechanochemical patterning in biphasic biological tissues,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 12. National Academy of Sciences, pp. 5344–5349, 2019.","mla":"Recho, Pierre, et al. “Theory of Mechanochemical Patterning in Biphasic Biological Tissues.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 116, no. 12, National Academy of Sciences, 2019, pp. 5344–49, doi:<a href=\"https://doi.org/10.1073/pnas.1813255116\">10.1073/pnas.1813255116</a>.","ama":"Recho P, Hallou A, Hannezo EB. Theory of mechanochemical patterning in biphasic biological tissues. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2019;116(12):5344-5349. doi:<a href=\"https://doi.org/10.1073/pnas.1813255116\">10.1073/pnas.1813255116</a>","apa":"Recho, P., Hallou, A., &#38; Hannezo, E. B. (2019). Theory of mechanochemical patterning in biphasic biological tissues. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1813255116\">https://doi.org/10.1073/pnas.1813255116</a>"},"volume":116,"file_date_updated":"2020-07-14T12:47:23Z","language":[{"iso":"eng"}],"related_material":{"link":[{"relation":"supplementary_material","url":"www.pnas.org/lookup/suppl/doi:10.1073/pnas.1813255116/-/DCSupplemental"}]},"title":"Theory of mechanochemical patterning in biphasic biological tissues","date_created":"2019-03-31T21:59:13Z","day":"19","abstract":[{"lang":"eng","text":"The formation of self-organized patterns is key to the morphogenesis of multicellular organisms, although a comprehensive theory of biological pattern formation is still lacking. Here, we propose a minimal model combining tissue mechanics with morphogen turnover and transport to explore routes to patterning. Our active description couples morphogen reaction and diffusion, which impact cell differentiation and tissue mechanics, to a two-phase poroelastic rheology, where one tissue phase consists of a poroelastic cell network and the other one of a permeating extracellular fluid, which provides a feedback by actively transporting morphogens. While this model encompasses previous theories approximating tissues to inert monophasic media, such as Turing’s reaction–diffusion model, it overcomes some of their key limitations permitting pattern formation via any two-species biochemical kinetics due to mechanically induced cross-diffusion flows. Moreover, we describe a qualitatively different advection-driven Keller–Segel instability which allows for the formation of patterns with a single morphogen and whose fundamental mode pattern robustly scales with tissue size. We discuss the potential relevance of these findings for tissue morphogenesis."}],"isi":1,"scopus_import":"1","pmid":1,"issue":"12","year":"2019","status":"public","has_accepted_license":"1","corr_author":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1091-6490"],"issn":["0027-8424"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"date_updated":"2020-07-14T12:47:23Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf","file_size":3456045,"checksum":"8b67eee0ea8e5db61583e4d485215258","file_id":"6193","file_name":"2019_PNAS_Recho.pdf","date_created":"2019-04-03T14:10:30Z","relation":"main_file"}],"oa":1,"department":[{"_id":"EdHa"}],"article_processing_charge":"No","publication_status":"published","date_updated":"2025-07-10T11:53:14Z","date_published":"2019-03-19T00:00:00Z","month":"03","publisher":"National Academy of Sciences"},{"day":"21","abstract":[{"text":"Great care is needed when interpreting claims about the genetic basis of human variation based on data from genome-wide association studies.","lang":"eng"}],"date_created":"2019-04-07T21:59:15Z","file_date_updated":"2020-07-14T12:47:24Z","volume":8,"title":"Why structure matters","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/body-height-bmi-disease-risk-co/","description":"News on IST Homepage"}]},"language":[{"iso":"eng"}],"isi":1,"scopus_import":"1","doi":"10.7554/eLife.45380","_id":"6230","author":[{"full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","last_name":"Barton"},{"first_name":"Joachim","full_name":"Hermisson, Joachim","last_name":"Hermisson"},{"last_name":"Nordborg","first_name":"Magnus","full_name":"Nordborg, Magnus"}],"quality_controlled":"1","intvolume":"         8","citation":{"short":"N.H. Barton, J. Hermisson, M. Nordborg, ELife 8 (2019).","chicago":"Barton, Nicholas H, Joachim Hermisson, and Magnus Nordborg. “Why Structure Matters.” <i>ELife</i>. eLife Sciences Publications, 2019. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>.","ista":"Barton NH, Hermisson J, Nordborg M. 2019. Why structure matters. eLife. 8, e45380.","ama":"Barton NH, Hermisson J, Nordborg M. Why structure matters. <i>eLife</i>. 2019;8. doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>","apa":"Barton, N. H., Hermisson, J., &#38; Nordborg, M. (2019). Why structure matters. <i>ELife</i>. eLife Sciences Publications. <a href=\"https://doi.org/10.7554/eLife.45380\">https://doi.org/10.7554/eLife.45380</a>","ieee":"N. H. Barton, J. Hermisson, and M. Nordborg, “Why structure matters,” <i>eLife</i>, vol. 8. eLife Sciences Publications, 2019.","mla":"Barton, Nicholas H., et al. “Why Structure Matters.” <i>ELife</i>, vol. 8, e45380, eLife Sciences Publications, 2019, doi:<a href=\"https://doi.org/10.7554/eLife.45380\">10.7554/eLife.45380</a>."},"external_id":{"isi":["000461988300001"]},"ddc":["570"],"publication":"eLife","type":"journal_article","department":[{"_id":"NiBa"}],"article_number":"e45380","article_processing_charge":"No","oa":1,"publisher":"eLife Sciences Publications","month":"03","date_published":"2019-03-21T00:00:00Z","publication_status":"published","date_updated":"2026-04-02T14:03:15Z","has_accepted_license":"1","status":"public","year":"2019","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"file":[{"creator":"dernst","content_type":"application/pdf","access_level":"open_access","file_size":298466,"checksum":"130d7544b57df4a6787e1263c2d7ea43","date_updated":"2020-07-14T12:47:24Z","file_name":"2019_eLife_Barton.pdf","date_created":"2019-04-11T11:43:38Z","relation":"main_file","file_id":"6293"}],"oa_version":"Published Version","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_identifier":{"eissn":["2050-084X"]}},{"oa":1,"department":[{"_id":"JaMa"}],"article_processing_charge":"No","month":"03","date_published":"2019-03-01T00:00:00Z","publication_status":"published","date_updated":"2025-07-10T11:53:17Z","publisher":"Institute of Mathematical Statistics","year":"2019","issue":"2","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["0091-1798"]},"oa_version":"Preprint","volume":47,"title":"Boundary regularity of stochastic PDEs","main_file_link":[{"url":"https://arxiv.org/abs/1705.05364","open_access":"1"}],"language":[{"iso":"eng"}],"abstract":[{"lang":"eng","text":"The boundary behaviour of solutions of stochastic PDEs with Dirichlet boundary conditions can be surprisingly—and in a sense, arbitrarily—bad: as shown by Krylov[ SIAM J. Math. Anal.34(2003) 1167–1182], for any α>0 one can find a simple 1-dimensional constant coefficient linear equation whose solution at the boundary is not α-Hölder continuous.We obtain a positive counterpart of this: under some mild regularity assumptions on the coefficients, solutions of semilinear SPDEs on C1 domains are proved to be α-Hölder continuous up to the boundary with some α>0."}],"day":"01","date_created":"2019-04-07T21:59:15Z","isi":1,"scopus_import":"1","author":[{"first_name":"Mate","full_name":"Gerencser, Mate","id":"44ECEDF2-F248-11E8-B48F-1D18A9856A87","last_name":"Gerencser"}],"page":"804-834","quality_controlled":"1","doi":"10.1214/18-AOP1272","_id":"6232","type":"journal_article","publication":"Annals of Probability","arxiv":1,"intvolume":"        47","citation":{"short":"M. Gerencser, Annals of Probability 47 (2019) 804–834.","chicago":"Gerencser, Mate. “Boundary Regularity of Stochastic PDEs.” <i>Annals of Probability</i>. Institute of Mathematical Statistics, 2019. <a href=\"https://doi.org/10.1214/18-AOP1272\">https://doi.org/10.1214/18-AOP1272</a>.","ista":"Gerencser M. 2019. Boundary regularity of stochastic PDEs. Annals of Probability. 47(2), 804–834.","ama":"Gerencser M. Boundary regularity of stochastic PDEs. <i>Annals of Probability</i>. 2019;47(2):804-834. doi:<a href=\"https://doi.org/10.1214/18-AOP1272\">10.1214/18-AOP1272</a>","apa":"Gerencser, M. (2019). Boundary regularity of stochastic PDEs. <i>Annals of Probability</i>. Institute of Mathematical Statistics. <a href=\"https://doi.org/10.1214/18-AOP1272\">https://doi.org/10.1214/18-AOP1272</a>","mla":"Gerencser, Mate. “Boundary Regularity of Stochastic PDEs.” <i>Annals of Probability</i>, vol. 47, no. 2, Institute of Mathematical Statistics, 2019, pp. 804–34, doi:<a href=\"https://doi.org/10.1214/18-AOP1272\">10.1214/18-AOP1272</a>.","ieee":"M. Gerencser, “Boundary regularity of stochastic PDEs,” <i>Annals of Probability</i>, vol. 47, no. 2. Institute of Mathematical Statistics, pp. 804–834, 2019."},"external_id":{"arxiv":["1705.05364"],"isi":["000459681900005"]}},{"doi":"10.1214/18-AIHP894","_id":"6240","project":[{"_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7","grant_number":"338804"}],"quality_controlled":"1","author":[{"id":"36D3D8B6-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes","full_name":"Alt, Johannes","last_name":"Alt"},{"last_name":"Erdös","orcid":"0000-0001-5366-9603","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","full_name":"Erdös, László","first_name":"László"},{"orcid":"0000-0002-4821-3297","last_name":"Krüger","first_name":"Torben H","full_name":"Krüger, Torben H","id":"3020C786-F248-11E8-B48F-1D18A9856A87"},{"id":"4D902E6A-F248-11E8-B48F-1D18A9856A87","first_name":"Yuriy","full_name":"Nemish, Yuriy","last_name":"Nemish","orcid":"0000-0002-7327-856X"}],"page":"661-696","citation":{"ista":"Alt J, Erdös L, Krüger TH, Nemish Y. 2019. Location of the spectrum of Kronecker random matrices. Annales de l’institut Henri Poincare. 55(2), 661–696.","chicago":"Alt, Johannes, László Erdös, Torben H Krüger, and Yuriy Nemish. “Location of the Spectrum of Kronecker Random Matrices.” <i>Annales de l’institut Henri Poincare</i>. Institut Henri Poincaré, 2019. <a href=\"https://doi.org/10.1214/18-AIHP894\">https://doi.org/10.1214/18-AIHP894</a>.","short":"J. Alt, L. Erdös, T.H. Krüger, Y. Nemish, Annales de l’institut Henri Poincare 55 (2019) 661–696.","ieee":"J. Alt, L. Erdös, T. H. Krüger, and Y. Nemish, “Location of the spectrum of Kronecker random matrices,” <i>Annales de l’institut Henri Poincare</i>, vol. 55, no. 2. Institut Henri Poincaré, pp. 661–696, 2019.","mla":"Alt, Johannes, et al. “Location of the Spectrum of Kronecker Random Matrices.” <i>Annales de l’institut Henri Poincare</i>, vol. 55, no. 2, Institut Henri Poincaré, 2019, pp. 661–96, doi:<a href=\"https://doi.org/10.1214/18-AIHP894\">10.1214/18-AIHP894</a>.","apa":"Alt, J., Erdös, L., Krüger, T. H., &#38; Nemish, Y. (2019). Location of the spectrum of Kronecker random matrices. <i>Annales de l’institut Henri Poincare</i>. Institut Henri Poincaré. <a href=\"https://doi.org/10.1214/18-AIHP894\">https://doi.org/10.1214/18-AIHP894</a>","ama":"Alt J, Erdös L, Krüger TH, Nemish Y. Location of the spectrum of Kronecker random matrices. <i>Annales de l’institut Henri Poincare</i>. 2019;55(2):661-696. doi:<a href=\"https://doi.org/10.1214/18-AIHP894\">10.1214/18-AIHP894</a>"},"external_id":{"isi":["000467793600003"],"arxiv":["1706.08343"]},"arxiv":1,"intvolume":"        55","publication":"Annales de l'institut Henri Poincare","type":"journal_article","day":"01","abstract":[{"text":"For a general class of large non-Hermitian random block matrices X we prove that there are no eigenvalues away from a deterministic set with very high probability. This set is obtained from the Dyson equation of the Hermitization of X as the self-consistent approximation of the pseudospectrum. We demonstrate that the analysis of the matrix Dyson equation from (Probab. Theory Related Fields (2018)) offers a unified treatment of many structured matrix ensembles.","lang":"eng"}],"date_created":"2019-04-08T14:05:04Z","title":"Location of the spectrum of Kronecker random matrices","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"149","relation":"dissertation_contains","status":"public"}]},"main_file_link":[{"url":"https://arxiv.org/abs/1706.08343","open_access":"1"}],"volume":55,"scopus_import":"1","isi":1,"issue":"2","year":"2019","status":"public","oa_version":"Preprint","publication_identifier":{"issn":["0246-0203"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","department":[{"_id":"LaEr"}],"oa":1,"publisher":"Institut Henri Poincaré","ec_funded":1,"date_published":"2019-05-01T00:00:00Z","month":"05","publication_status":"published","date_updated":"2026-04-08T14:11:36Z"},{"publication_identifier":{"eissn":["1476-4687"],"issn":["0028-0836"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","file":[{"file_id":"8751","relation":"main_file","file_name":"2019_Nature _Cao_accepted.pdf","date_created":"2020-11-13T07:37:41Z","date_updated":"2020-11-13T07:37:41Z","success":1,"creator":"dernst","access_level":"open_access","checksum":"6b84ab602a34382cf0340a37a1378c75","content_type":"application/pdf","file_size":4321328}],"oa_version":"Submitted Version","year":"2019","status":"public","has_accepted_license":"1","month":"04","date_published":"2019-04-11T00:00:00Z","article_type":"original","publication_status":"published","date_updated":"2025-04-14T07:45:04Z","publisher":"Springer Nature","ec_funded":1,"oa":1,"article_processing_charge":"No","department":[{"_id":"JiFr"}],"type":"journal_article","publication":"Nature","citation":{"ista":"Cao M, Chen R, Li P, Yu Y, Zheng R, Ge D, Zheng W, Wang X, Gu Y, Gelová Z, Friml J, Zhang H, Liu R, He J, Xu T. 2019. TMK1-mediated auxin signalling regulates differential growth of the apical hook. Nature. 568, 240–243.","short":"M. Cao, R. Chen, P. Li, Y. Yu, R. Zheng, D. Ge, W. Zheng, X. Wang, Y. Gu, Z. Gelová, J. Friml, H. Zhang, R. Liu, J. He, T. Xu, Nature 568 (2019) 240–243.","chicago":"Cao, Min, Rong Chen, Pan Li, Yongqiang Yu, Rui Zheng, Danfeng Ge, Wei Zheng, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>.","mla":"Cao, Min, et al. “TMK1-Mediated Auxin Signalling Regulates Differential Growth of the Apical Hook.” <i>Nature</i>, vol. 568, Springer Nature, 2019, pp. 240–43, doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>.","ieee":"M. Cao <i>et al.</i>, “TMK1-mediated auxin signalling regulates differential growth of the apical hook,” <i>Nature</i>, vol. 568. Springer Nature, pp. 240–243, 2019.","ama":"Cao M, Chen R, Li P, et al. TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. 2019;568:240-243. doi:<a href=\"https://doi.org/10.1038/s41586-019-1069-7\">10.1038/s41586-019-1069-7</a>","apa":"Cao, M., Chen, R., Li, P., Yu, Y., Zheng, R., Ge, D., … Xu, T. (2019). TMK1-mediated auxin signalling regulates differential growth of the apical hook. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1069-7\">https://doi.org/10.1038/s41586-019-1069-7</a>"},"external_id":{"isi":["000464412700050"],"pmid":["30944466"]},"ddc":["580"],"intvolume":"       568","quality_controlled":"1","page":"240-243","author":[{"full_name":"Cao, Min","first_name":"Min","last_name":"Cao"},{"last_name":"Chen","first_name":"Rong","full_name":"Chen, Rong"},{"last_name":"Li","full_name":"Li, Pan","first_name":"Pan"},{"last_name":"Yu","first_name":"Yongqiang","full_name":"Yu, Yongqiang"},{"last_name":"Zheng","full_name":"Zheng, Rui","first_name":"Rui"},{"full_name":"Ge, Danfeng","first_name":"Danfeng","last_name":"Ge"},{"last_name":"Zheng","first_name":"Wei","full_name":"Zheng, Wei"},{"last_name":"Wang","full_name":"Wang, Xuhui","first_name":"Xuhui"},{"last_name":"Gu","first_name":"Yangtao","full_name":"Gu, Yangtao"},{"id":"0AE74790-0E0B-11E9-ABC7-1ACFE5697425","full_name":"Gelová, Zuzana","first_name":"Zuzana","last_name":"Gelová","orcid":"0000-0003-4783-1752"},{"first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","last_name":"Friml"},{"full_name":"Zhang, Heng","first_name":"Heng","last_name":"Zhang"},{"last_name":"Liu","full_name":"Liu, Renyi","first_name":"Renyi"},{"last_name":"He","first_name":"Jun","full_name":"He, Jun"},{"last_name":"Xu","full_name":"Xu, Tongda","first_name":"Tongda"}],"doi":"10.1038/s41586-019-1069-7","_id":"6259","project":[{"_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants"}],"scopus_import":"1","isi":1,"pmid":1,"title":"TMK1-mediated auxin signalling regulates differential growth of the apical hook","language":[{"iso":"eng"}],"related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/newly-discovered-mechanism-of-plant-hormone-auxin-acts-the-opposite-way/","description":"News on IST Homepage"}]},"file_date_updated":"2020-11-13T07:37:41Z","volume":568,"day":"11","abstract":[{"lang":"eng","text":"The plant hormone auxin has crucial roles in almost all aspects of plant growth and development. Concentrations of auxin vary across different tissues, mediating distinct developmental outcomes and contributing to the functional diversity of auxin. However, the mechanisms that underlie these activities are poorly understood. Here we identify an auxin signalling mechanism, which acts in parallel to the canonical auxin pathway based on the transport inhibitor response1 (TIR1) and other auxin receptor F-box (AFB) family proteins (TIR1/AFB receptors)1,2, that translates levels of cellular auxin to mediate differential growth during apical-hook development. This signalling mechanism operates at the concave side of the apical hook, and involves auxin-mediated C-terminal cleavage of transmembrane kinase 1 (TMK1). The cytosolic and nucleus-translocated C terminus of TMK1 specifically interacts with and phosphorylates two non-canonical transcriptional repressors of the auxin or indole-3-acetic acid (Aux/IAA) family (IAA32 and IAA34), thereby regulating ARF transcription factors. In contrast to the degradation of Aux/IAA transcriptional repressors in the canonical pathway, the newly identified mechanism stabilizes the non-canonical IAA32 and IAA34 transcriptional repressors to regulate gene expression and ultimately inhibit growth. The auxin–TMK1 signalling pathway originates at the cell surface, is triggered by high levels of auxin and shares a partially overlapping set of transcription factors with the TIR1/AFB signalling pathway. This allows distinct interpretations of different concentrations of cellular auxin, and thus enables this versatile signalling molecule to mediate complex developmental outcomes."}],"date_created":"2019-04-09T08:37:05Z"},{"publication":"Plant Physiology","type":"journal_article","intvolume":"       180","citation":{"ieee":"Y. Wang, Z. Gong, J. Friml, and J. Zhang, “Nitrate modulates the differentiation of root distal stem cells,” <i>Plant Physiology</i>, vol. 180, no. 1. ASPB, pp. 22–25, 2019.","mla":"Wang, Y., et al. “Nitrate Modulates the Differentiation of Root Distal Stem Cells.” <i>Plant Physiology</i>, vol. 180, no. 1, ASPB, 2019, pp. 22–25, doi:<a href=\"https://doi.org/10.1104/pp.18.01305\">10.1104/pp.18.01305</a>.","apa":"Wang, Y., Gong, Z., Friml, J., &#38; Zhang, J. (2019). Nitrate modulates the differentiation of root distal stem cells. <i>Plant Physiology</i>. ASPB. <a href=\"https://doi.org/10.1104/pp.18.01305\">https://doi.org/10.1104/pp.18.01305</a>","ama":"Wang Y, Gong Z, Friml J, Zhang J. Nitrate modulates the differentiation of root distal stem cells. <i>Plant Physiology</i>. 2019;180(1):22-25. doi:<a href=\"https://doi.org/10.1104/pp.18.01305\">10.1104/pp.18.01305</a>","ista":"Wang Y, Gong Z, Friml J, Zhang J. 2019. Nitrate modulates the differentiation of root distal stem cells. Plant Physiology. 180(1), 22–25.","chicago":"Wang, Y, Z Gong, Jiří Friml, and J Zhang. “Nitrate Modulates the Differentiation of Root Distal Stem Cells.” <i>Plant Physiology</i>. ASPB, 2019. <a href=\"https://doi.org/10.1104/pp.18.01305\">https://doi.org/10.1104/pp.18.01305</a>.","short":"Y. Wang, Z. Gong, J. Friml, J. Zhang, Plant Physiology 180 (2019) 22–25."},"ddc":["580"],"external_id":{"isi":["000466860800010"],"pmid":["30787134"]},"author":[{"first_name":"Y","full_name":"Wang, Y","last_name":"Wang"},{"last_name":"Gong","first_name":"Z","full_name":"Gong, Z"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Zhang","first_name":"J","full_name":"Zhang, J"}],"page":"22-25","quality_controlled":"1","doi":"10.1104/pp.18.01305","_id":"6261","isi":1,"scopus_import":"1","pmid":1,"volume":180,"title":"Nitrate modulates the differentiation of root distal stem cells","main_file_link":[{"url":"https://doi.org/10.1104/pp.18.01305","open_access":"1"}],"language":[{"iso":"eng"}],"day":"01","abstract":[{"lang":"eng","text":"Nitrate regulation of root stem cell activity is auxin-dependent."}],"date_created":"2019-04-09T08:46:17Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1532-2548"],"issn":["0032-0889"]},"oa_version":"Published Version","status":"public","year":"2019","issue":"1","date_published":"2019-05-01T00:00:00Z","article_type":"letter_note","month":"05","date_updated":"2026-06-18T19:02:50Z","publication_status":"published","publisher":"ASPB","oa":1,"department":[{"_id":"JiFr"}],"article_processing_charge":"No"},{"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"issn":["0960-7412"],"eissn":["1365-313x"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"oa_version":"Published Version","file":[{"date_created":"2019-04-15T09:38:43Z","file_name":"2019_PlantJournal_Rakusov.pdf","relation":"main_file","file_id":"6304","content_type":"application/pdf","file_size":1383100,"access_level":"open_access","checksum":"ad3b5e270b67ba2a45f894ce3be27920","creator":"dernst","date_updated":"2020-07-14T12:47:25Z"}],"status":"public","issue":"6","year":"2019","has_accepted_license":"1","date_updated":"2025-04-15T07:48:04Z","publication_status":"published","date_published":"2019-06-01T00:00:00Z","month":"06","article_type":"original","ec_funded":1,"publisher":"Wiley","oa":1,"department":[{"_id":"JiFr"}],"article_processing_charge":"Yes (via OA deal)","type":"journal_article","publication":"The Plant Journal","intvolume":"        98","external_id":{"isi":["000473644100008"],"pmid":["30821050"]},"ddc":["580"],"citation":{"chicago":"Rakusová, Hana, Huibin Han, Petr Valošek, and Jiří Friml. “Genetic Screen for Factors Mediating PIN Polarization in Gravistimulated Arabidopsis Thaliana Hypocotyls.” <i>The Plant Journal</i>. Wiley, 2019. <a href=\"https://doi.org/10.1111/tpj.14301\">https://doi.org/10.1111/tpj.14301</a>.","short":"H. Rakusová, H. Han, P. Valošek, J. Friml, The Plant Journal 98 (2019) 1048–1059.","ista":"Rakusová H, Han H, Valošek P, Friml J. 2019. Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls. The Plant Journal. 98(6), 1048–1059.","apa":"Rakusová, H., Han, H., Valošek, P., &#38; Friml, J. (2019). Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls. <i>The Plant Journal</i>. Wiley. <a href=\"https://doi.org/10.1111/tpj.14301\">https://doi.org/10.1111/tpj.14301</a>","ama":"Rakusová H, Han H, Valošek P, Friml J. Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls. <i>The Plant Journal</i>. 2019;98(6):1048-1059. doi:<a href=\"https://doi.org/10.1111/tpj.14301\">10.1111/tpj.14301</a>","ieee":"H. Rakusová, H. Han, P. Valošek, and J. Friml, “Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls,” <i>The Plant Journal</i>, vol. 98, no. 6. Wiley, pp. 1048–1059, 2019.","mla":"Rakusová, Hana, et al. “Genetic Screen for Factors Mediating PIN Polarization in Gravistimulated Arabidopsis Thaliana Hypocotyls.” <i>The Plant Journal</i>, vol. 98, no. 6, Wiley, 2019, pp. 1048–59, doi:<a href=\"https://doi.org/10.1111/tpj.14301\">10.1111/tpj.14301</a>."},"page":"1048-1059","author":[{"last_name":"Rakusová","first_name":"Hana","full_name":"Rakusová, Hana"},{"last_name":"Han","full_name":"Han, Huibin","first_name":"Huibin","id":"31435098-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Valošek","first_name":"Petr","full_name":"Valošek, Petr","id":"3CDB6F94-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jiří","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"quality_controlled":"1","project":[{"grant_number":"282300","call_identifier":"FP7","name":"Polarity and subcellular dynamics in plants","_id":"25716A02-B435-11E9-9278-68D0E5697425"}],"_id":"6262","doi":"10.1111/tpj.14301","isi":1,"scopus_import":"1","pmid":1,"volume":98,"file_date_updated":"2020-07-14T12:47:25Z","language":[{"iso":"eng"}],"title":"Genetic screen for factors mediating PIN polarization in gravistimulated Arabidopsis thaliana hypocotyls","date_created":"2019-04-09T08:46:44Z","abstract":[{"lang":"eng","text":"Gravitropism is an adaptive response that orients plant growth parallel to the gravity vector. Asymmetric\r\ndistribution of the phytohormone auxin is a necessary prerequisite to the tropic bending both in roots and\r\nshoots. During hypocotyl gravitropic response, the PIN3 auxin transporter polarizes within gravity-sensing\r\ncells to redirect intercellular auxin fluxes. First gravity-induced PIN3 polarization to the bottom cell mem-\r\nbranes leads to the auxin accumulation at the lower side of the organ, initiating bending and, later, auxin\r\nfeedback-mediated repolarization restores symmetric auxin distribution to terminate bending. Here, we per-\r\nformed a forward genetic screen to identify regulators of both PIN3 polarization events during gravitropic\r\nresponse. We searched for mutants with defective PIN3 polarizations based on easy-to-score morphological\r\noutputs of decreased or increased gravity-induced hypocotyl bending. We identified the number of\r\nhypocotyl reduced bending (hrb) and hypocotyl hyperbending (hhb) mutants, revealing that reduced bending corre-\r\nlated typically with defective gravity-induced PIN3 relocation whereas all analyzed hhb mutants showed\r\ndefects in the second, auxin-mediated PIN3 relocation. Next-generation sequencing-aided mutation map-\r\nping identified several candidate genes, including SCARECROW and ACTIN2, revealing roles of endodermis\r\nspecification and actin cytoskeleton in the respective gravity- and auxin-induced PIN polarization events.\r\nThe hypocotyl gravitropism screen thus promises to provide novel insights into mechanisms underlying cell\r\npolarity and plant adaptive development."}],"day":"01"},{"publication_identifier":{"issn":["0945-053X"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Submitted Version","file":[{"date_updated":"2020-07-14T12:47:27Z","creator":"dernst","content_type":"application/pdf","checksum":"790878cd78bfc54a147ddcc7c8f286a0","file_size":4444339,"access_level":"open_access","file_id":"7825","file_name":"2018_MatrixBiology_Davies.pdf","date_created":"2020-05-14T09:02:07Z","relation":"main_file"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"status":"public","year":"2019","has_accepted_license":"1","publication_status":"published","date_updated":"2023-08-25T10:11:28Z","date_published":"2019-05-01T00:00:00Z","month":"05","article_type":"original","publisher":"Elsevier","oa":1,"article_processing_charge":"No","department":[{"_id":"MaLo"}],"publication":"Matrix Biology","type":"journal_article","external_id":{"isi":["000468707600005"]},"ddc":["570"],"citation":{"ista":"Davies HS, Baranova NS, El Amri N, Coche-Guérente L, Verdier C, Bureau L, Richter RP, Débarre D. 2019. An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments. Matrix Biology. 78–79, 47–59.","short":"H.S. Davies, N.S. Baranova, N. El Amri, L. Coche-Guérente, C. Verdier, L. Bureau, R.P. Richter, D. Débarre, Matrix Biology 78–79 (2019) 47–59.","chicago":"Davies, Heather S., Natalia S. Baranova, Nouha El Amri, Liliane Coche-Guérente, Claude Verdier, Lionel Bureau, Ralf P. Richter, and Delphine Débarre. “An Integrated Assay to Probe Endothelial Glycocalyx-Blood Cell Interactions under Flow in Mechanically and Biochemically Well-Defined Environments.” <i>Matrix Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.matbio.2018.12.002\">https://doi.org/10.1016/j.matbio.2018.12.002</a>.","mla":"Davies, Heather S., et al. “An Integrated Assay to Probe Endothelial Glycocalyx-Blood Cell Interactions under Flow in Mechanically and Biochemically Well-Defined Environments.” <i>Matrix Biology</i>, vol. 78–79, Elsevier, 2019, pp. 47–59, doi:<a href=\"https://doi.org/10.1016/j.matbio.2018.12.002\">10.1016/j.matbio.2018.12.002</a>.","ieee":"H. S. Davies <i>et al.</i>, “An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments,” <i>Matrix Biology</i>, vol. 78–79. Elsevier, pp. 47–59, 2019.","ama":"Davies HS, Baranova NS, El Amri N, et al. An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments. <i>Matrix Biology</i>. 2019;78-79:47-59. doi:<a href=\"https://doi.org/10.1016/j.matbio.2018.12.002\">10.1016/j.matbio.2018.12.002</a>","apa":"Davies, H. S., Baranova, N. S., El Amri, N., Coche-Guérente, L., Verdier, C., Bureau, L., … Débarre, D. (2019). An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments. <i>Matrix Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.matbio.2018.12.002\">https://doi.org/10.1016/j.matbio.2018.12.002</a>"},"quality_controlled":"1","page":"47-59","author":[{"full_name":"Davies, Heather S.","first_name":"Heather S.","last_name":"Davies"},{"id":"38661662-F248-11E8-B48F-1D18A9856A87","full_name":"Baranova, Natalia S.","first_name":"Natalia S.","last_name":"Baranova","orcid":"0000-0002-3086-9124"},{"first_name":"Nouha","full_name":"El Amri, Nouha","last_name":"El Amri"},{"full_name":"Coche-Guérente, Liliane","first_name":"Liliane","last_name":"Coche-Guérente"},{"last_name":"Verdier","first_name":"Claude","full_name":"Verdier, Claude"},{"last_name":"Bureau","first_name":"Lionel","full_name":"Bureau, Lionel"},{"full_name":"Richter, Ralf P.","first_name":"Ralf P.","last_name":"Richter"},{"last_name":"Débarre","first_name":"Delphine","full_name":"Débarre, Delphine"}],"_id":"6297","doi":"10.1016/j.matbio.2018.12.002","isi":1,"language":[{"iso":"eng"}],"title":"An integrated assay to probe endothelial glycocalyx-blood cell interactions under flow in mechanically and biochemically well-defined environments","volume":"78-79","file_date_updated":"2020-07-14T12:47:27Z","date_created":"2019-04-11T20:55:01Z","day":"01","abstract":[{"text":"Cell-cell and cell-glycocalyx interactions under flow are important for the behaviour of circulating cells in blood and lymphatic vessels. However, such interactions are not well understood due in part to a lack of tools to study them in defined environments. Here, we develop a versatile in vitro platform for the study of cell-glycocalyx interactions in well-defined physical and chemical settings under flow. Our approach is demonstrated with the interaction between hyaluronan (HA, a key component of the endothelial glycocalyx) and its cell receptor CD44. We generate HA brushes in situ within a microfluidic device, and demonstrate the tuning of their physical (thickness and softness) and chemical (density of CD44 binding sites) properties using characterisation with reflection interference contrast microscopy (RICM) and application of polymer theory. We highlight the interactions of HA brushes with CD44-displaying beads and cells under flow. Observations of CD44+ beads on a HA brush with RICM enabled the 3-dimensional trajectories to be generated, and revealed interactions in the form of stop and go phases with reduced rolling velocity and reduced distance between the bead and the HA brush, compared to uncoated beads. Combined RICM and bright-field microscopy of CD44+ AKR1 T-lymphocytes revealed complementary information about the dynamics of cell rolling and cell morphology, and highlighted the formation of tethers and slings, as they interacted with a HA brush under flow. This platform can readily incorporate more complex models of the glycocalyx, and should permit the study of how mechanical and biochemical factors are orchestrated to enable highly selective blood cell-vessel wall interactions under flow.","lang":"eng"}]},{"type":"journal_article","publication":"Advances in Mathematics","intvolume":"       349","arxiv":1,"external_id":{"arxiv":["1810.08426"],"isi":["000468857300025"]},"ddc":["512"],"citation":{"ista":"Browning TD, Hu LQ. 2019. Counting rational points on biquadratic hypersurfaces. Advances in Mathematics. 349, 920–940.","chicago":"Browning, Timothy D, and L.Q. Hu. “Counting Rational Points on Biquadratic Hypersurfaces.” <i>Advances in Mathematics</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.aim.2019.04.031\">https://doi.org/10.1016/j.aim.2019.04.031</a>.","short":"T.D. Browning, L.Q. Hu, Advances in Mathematics 349 (2019) 920–940.","ieee":"T. D. Browning and L. Q. Hu, “Counting rational points on biquadratic hypersurfaces,” <i>Advances in Mathematics</i>, vol. 349. Elsevier, pp. 920–940, 2019.","mla":"Browning, Timothy D., and L. Q. Hu. “Counting Rational Points on Biquadratic Hypersurfaces.” <i>Advances in Mathematics</i>, vol. 349, Elsevier, 2019, pp. 920–40, doi:<a href=\"https://doi.org/10.1016/j.aim.2019.04.031\">10.1016/j.aim.2019.04.031</a>.","apa":"Browning, T. D., &#38; Hu, L. Q. (2019). Counting rational points on biquadratic hypersurfaces. <i>Advances in Mathematics</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.aim.2019.04.031\">https://doi.org/10.1016/j.aim.2019.04.031</a>","ama":"Browning TD, Hu LQ. Counting rational points on biquadratic hypersurfaces. <i>Advances in Mathematics</i>. 2019;349:920-940. doi:<a href=\"https://doi.org/10.1016/j.aim.2019.04.031\">10.1016/j.aim.2019.04.031</a>"},"author":[{"last_name":"Browning","orcid":"0000-0002-8314-0177","id":"35827D50-F248-11E8-B48F-1D18A9856A87","first_name":"Timothy D","full_name":"Browning, Timothy D"},{"full_name":"Hu, L.Q.","first_name":"L.Q.","last_name":"Hu"}],"page":"920-940","quality_controlled":"1","_id":"6310","doi":"10.1016/j.aim.2019.04.031","isi":1,"scopus_import":"1","volume":349,"file_date_updated":"2020-07-14T12:47:27Z","language":[{"iso":"eng"}],"title":"Counting rational points on biquadratic hypersurfaces","date_created":"2019-04-16T09:13:25Z","day":"20","abstract":[{"text":"An asymptotic formula is established for the number of rational points of bounded anticanonical height which lie on a certain Zariskiopen subset of an arbitrary smooth biquadratic hypersurface in sufficiently many variables. The proof uses the Hardy–Littlewood circle method.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"eissn":["1090-2082"],"issn":["0001-8708"]},"oa_version":"Submitted Version","file":[{"date_updated":"2020-07-14T12:47:27Z","checksum":"a63594a3a91b4ba6e2a1b78b0720b3d0","access_level":"open_access","file_size":379158,"content_type":"application/pdf","creator":"tbrownin","file_id":"6311","relation":"main_file","date_created":"2019-04-16T09:12:20Z","file_name":"wliqun.pdf"}],"year":"2019","status":"public","has_accepted_license":"1","date_updated":"2025-07-10T11:53:19Z","publication_status":"published","month":"06","date_published":"2019-06-20T00:00:00Z","publisher":"Elsevier","oa":1,"department":[{"_id":"TiBr"}],"article_processing_charge":"No"},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","status":"public","year":"2019","month":"04","article_type":"original","date_published":"2019-04-17T00:00:00Z","date_updated":"2026-06-18T19:03:23Z","publication_status":"published","ec_funded":1,"publisher":"Elsevier","oa":1,"department":[{"_id":"JoCs"}],"article_processing_charge":"No","publication":"Neuron","type":"journal_article","intvolume":"       102","citation":{"ista":"Stella F, Baracskay P, O’Neill J, Csicsvari JL. 2019. Hippocampal reactivation of random trajectories resembling Brownian diffusion. Neuron. 102, 450–461.","chicago":"Stella, Federico, Peter Baracskay, Joseph O’Neill, and Jozsef L Csicsvari. “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.” <i>Neuron</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.neuron.2019.01.052\">https://doi.org/10.1016/j.neuron.2019.01.052</a>.","short":"F. Stella, P. Baracskay, J. O’Neill, J.L. Csicsvari, Neuron 102 (2019) 450–461.","ieee":"F. Stella, P. Baracskay, J. O’Neill, and J. L. Csicsvari, “Hippocampal reactivation of random trajectories resembling Brownian diffusion,” <i>Neuron</i>, vol. 102. Elsevier, pp. 450–461, 2019.","mla":"Stella, Federico, et al. “Hippocampal Reactivation of Random Trajectories Resembling Brownian Diffusion.” <i>Neuron</i>, vol. 102, Elsevier, 2019, pp. 450–61, doi:<a href=\"https://doi.org/10.1016/j.neuron.2019.01.052\">10.1016/j.neuron.2019.01.052</a>.","apa":"Stella, F., Baracskay, P., O’Neill, J., &#38; Csicsvari, J. L. (2019). Hippocampal reactivation of random trajectories resembling Brownian diffusion. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2019.01.052\">https://doi.org/10.1016/j.neuron.2019.01.052</a>","ama":"Stella F, Baracskay P, O’Neill J, Csicsvari JL. Hippocampal reactivation of random trajectories resembling Brownian diffusion. <i>Neuron</i>. 2019;102:450-461. doi:<a href=\"https://doi.org/10.1016/j.neuron.2019.01.052\">10.1016/j.neuron.2019.01.052</a>"},"external_id":{"isi":["000465169700017"],"pmid":["30819547"]},"ddc":["570"],"page":"450-461","author":[{"id":"39AF1E74-F248-11E8-B48F-1D18A9856A87","first_name":"Federico","full_name":"Stella, Federico","last_name":"Stella","orcid":"0000-0001-9439-3148"},{"id":"361CC00E-F248-11E8-B48F-1D18A9856A87","full_name":"Baracskay, Peter","first_name":"Peter","last_name":"Baracskay"},{"id":"426376DC-F248-11E8-B48F-1D18A9856A87","full_name":"O'Neill, Joseph","first_name":"Joseph","last_name":"O'Neill"},{"full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5193-4036","last_name":"Csicsvari"}],"quality_controlled":"1","project":[{"name":"Memory-related information processing in neuronal circuits of the hippocampus and entorhinal cortex","grant_number":"281511","call_identifier":"FP7","_id":"257A4776-B435-11E9-9278-68D0E5697425"},{"_id":"2654F984-B435-11E9-9278-68D0E5697425","grant_number":"I 3713-B27","call_identifier":"FWF","name":"Interneuro plasticity during spatial learning"}],"doi":"10.1016/j.neuron.2019.01.052","_id":"6338","isi":1,"scopus_import":"1","pmid":1,"volume":102,"title":"Hippocampal reactivation of random trajectories resembling Brownian diffusion","main_file_link":[{"url":"https://doi.org/10.1016/j.neuron.2019.01.052","open_access":"1"}],"language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/memories-of-movement-are-replayed-randomly-during-sleep/","description":"News on IST Homepage","relation":"press_release"}]},"abstract":[{"text":"Hippocampal activity patterns representing movement trajectories are reactivated in immobility and sleep periods, a process associated with memory recall, consolidation, and decision making. It is thought that only fixed, behaviorally relevant patterns can be reactivated, which are stored across hippocampal synaptic connections. To test whether some generalized rules govern reactivation, we examined trajectory reactivation following non-stereotypical exploration of familiar open-field environments. We found that random trajectories of varying lengths and timescales were reactivated, resembling that of Brownian motion of particles. The animals’ behavioral trajectory did not follow Brownian diffusion demonstrating that the exact behavioral experience is not reactivated. Therefore, hippocampal circuits are able to generate random trajectories of any recently active map by following diffusion dynamics. This ability of hippocampal circuits to generate representations of all behavioral outcome combinations, experienced or not, may underlie a wide variety of hippocampal-dependent cognitive functions such as learning, generalization, and planning.","lang":"eng"}],"day":"17","date_created":"2019-04-17T08:28:59Z"},{"external_id":{"isi":["000494891800004"]},"citation":{"ieee":"F. K. Schur, “Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging,” <i>Current Opinion in Structural Biology</i>, vol. 58, no. 10. Elsevier, pp. 1–9, 2019.","mla":"Schur, Florian KM. “Toward High-Resolution in Situ Structural Biology with Cryo-Electron Tomography and Subtomogram Averaging.” <i>Current Opinion in Structural Biology</i>, vol. 58, no. 10, Elsevier, 2019, pp. 1–9, doi:<a href=\"https://doi.org/10.1016/j.sbi.2019.03.018\">10.1016/j.sbi.2019.03.018</a>.","apa":"Schur, F. K. (2019). Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging. <i>Current Opinion in Structural Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.sbi.2019.03.018\">https://doi.org/10.1016/j.sbi.2019.03.018</a>","ama":"Schur FK. Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging. <i>Current Opinion in Structural Biology</i>. 2019;58(10):1-9. doi:<a href=\"https://doi.org/10.1016/j.sbi.2019.03.018\">10.1016/j.sbi.2019.03.018</a>","ista":"Schur FK. 2019. Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging. Current Opinion in Structural Biology. 58(10), 1–9.","chicago":"Schur, Florian KM. “Toward High-Resolution in Situ Structural Biology with Cryo-Electron Tomography and Subtomogram Averaging.” <i>Current Opinion in Structural Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.sbi.2019.03.018\">https://doi.org/10.1016/j.sbi.2019.03.018</a>.","short":"F.K. Schur, Current Opinion in Structural Biology 58 (2019) 1–9."},"acknowledgement":"The author acknowledges support from IST Austria and the Austrian Science Fund (FWF).","intvolume":"        58","publication":"Current Opinion in Structural Biology","type":"journal_article","_id":"6343","doi":"10.1016/j.sbi.2019.03.018","quality_controlled":"1","author":[{"last_name":"Schur","orcid":"0000-0003-4790-8078","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian KM","first_name":"Florian KM"}],"page":"1-9","scopus_import":"1","isi":1,"date_created":"2019-04-19T11:19:13Z","abstract":[{"text":"Cryo-electron tomography (cryo-ET) provides unprecedented insights into the molecular constituents of biological environments. In combination with an image processing method called subtomogram averaging (STA), detailed 3D structures of biological molecules can be obtained in large, irregular macromolecular assemblies or in situ, without the need for purification. The contextual meta-information these methods also provide, such as a protein’s location within its native environment, can then be combined with functional data. This allows the derivation of a detailed view on the physiological or pathological roles of proteins from the molecular to cellular level. Despite their tremendous potential in in situ structural biology, cryo-ET and STA have been restricted by methodological limitations, such as the low obtainable resolution. Exciting progress now allows one to reach unprecedented resolutions in situ, ranging in optimal cases beyond the nanometer barrier. Here, I review current frontiers and future challenges in routinely determining high-resolution structures in in situ environments using cryo-ET and STA.","lang":"eng"}],"day":"01","language":[{"iso":"eng"}],"title":"Toward high-resolution in situ structural biology with cryo-electron tomography and subtomogram averaging","volume":58,"oa_version":"None","publication_identifier":{"issn":["0959-440X"]},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"10","status":"public","year":"2019","publisher":"Elsevier","date_updated":"2023-08-25T10:13:31Z","publication_status":"published","article_type":"original","month":"10","date_published":"2019-10-01T00:00:00Z","article_processing_charge":"No","department":[{"_id":"FlSc"}]},{"article_processing_charge":"No","department":[{"_id":"JoFi"}],"oa":1,"publisher":"Springer Nature","date_updated":"2025-07-10T11:53:19Z","publication_status":"published","date_published":"2019-04-18T00:00:00Z","month":"04","year":"2019","status":"public","issue":"7752","oa_version":"Preprint","publication_identifier":{"issn":["0028-0836"],"eissn":["1476-4687"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_created":"2019-04-28T21:59:13Z","day":"18","abstract":[{"lang":"eng","text":"High-speed optical telecommunication is enabled by wavelength-division multiplexing, whereby hundreds of individually stabilized lasers encode information within a single-mode optical fibre. Higher bandwidths require higher total optical power, but the power sent into the fibre is limited by optical nonlinearities within the fibre, and energy consumption by the light sources starts to become a substantial cost factor1. Optical frequency combs have been suggested to remedy this problem by generating numerous discrete, equidistant laser lines within a monolithic device; however, at present their stability and coherence allow them to operate only within small parameter ranges2,3,4. Here we show that a broadband frequency comb realized through the electro-optic effect within a high-quality whispering-gallery-mode resonator can operate at low microwave and optical powers. Unlike the usual third-order Kerr nonlinear optical frequency combs, our combs rely on the second-order nonlinear effect, which is much more efficient. Our result uses a fixed microwave signal that is mixed with an optical-pump signal to generate a coherent frequency comb with a precisely determined carrier separation. The resonant enhancement enables us to work with microwave powers that are three orders of magnitude lower than those in commercially available devices. We emphasize the practical relevance of our results to high rates of data communication. To circumvent the limitations imposed by nonlinear effects in optical communication fibres, one has to solve two problems: to provide a compact and fully integrated, yet high-quality and coherent, frequency comb generator; and to calculate nonlinear signal propagation in real time5. We report a solution to the first problem."}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1808.10608"}],"language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://doi.org/10.1038/s41586-019-1220-5","relation":"erratum"}]},"title":"Resonant electro-optic frequency comb","volume":568,"scopus_import":"1","isi":1,"_id":"6348","doi":"10.1038/s41586-019-1110-x","quality_controlled":"1","page":"378-381","author":[{"id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","full_name":"Rueda Sanchez, Alfredo R","first_name":"Alfredo R","last_name":"Rueda Sanchez","orcid":"0000-0001-6249-5860"},{"last_name":"Sedlmeir","full_name":"Sedlmeir, Florian","first_name":"Florian"},{"full_name":"Kumari, Madhuri","first_name":"Madhuri","last_name":"Kumari"},{"full_name":"Leuchs, Gerd","first_name":"Gerd","last_name":"Leuchs"},{"last_name":"Schwefel","first_name":"Harald G.L.","full_name":"Schwefel, Harald G.L."}],"external_id":{"arxiv":["1808.10608"],"isi":["000464950700053"]},"citation":{"ista":"Rueda Sanchez AR, Sedlmeir F, Kumari M, Leuchs G, Schwefel HGL. 2019. Resonant electro-optic frequency comb. Nature. 568(7752), 378–381.","short":"A.R. Rueda Sanchez, F. Sedlmeir, M. Kumari, G. Leuchs, H.G.L. Schwefel, Nature 568 (2019) 378–381.","chicago":"Rueda Sanchez, Alfredo R, Florian Sedlmeir, Madhuri Kumari, Gerd Leuchs, and Harald G.L. Schwefel. “Resonant Electro-Optic Frequency Comb.” <i>Nature</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41586-019-1110-x\">https://doi.org/10.1038/s41586-019-1110-x</a>.","ieee":"A. R. Rueda Sanchez, F. Sedlmeir, M. Kumari, G. Leuchs, and H. G. L. Schwefel, “Resonant electro-optic frequency comb,” <i>Nature</i>, vol. 568, no. 7752. Springer Nature, pp. 378–381, 2019.","mla":"Rueda Sanchez, Alfredo R., et al. “Resonant Electro-Optic Frequency Comb.” <i>Nature</i>, vol. 568, no. 7752, Springer Nature, 2019, pp. 378–81, doi:<a href=\"https://doi.org/10.1038/s41586-019-1110-x\">10.1038/s41586-019-1110-x</a>.","ama":"Rueda Sanchez AR, Sedlmeir F, Kumari M, Leuchs G, Schwefel HGL. Resonant electro-optic frequency comb. <i>Nature</i>. 2019;568(7752):378-381. doi:<a href=\"https://doi.org/10.1038/s41586-019-1110-x\">10.1038/s41586-019-1110-x</a>","apa":"Rueda Sanchez, A. R., Sedlmeir, F., Kumari, M., Leuchs, G., &#38; Schwefel, H. G. L. (2019). Resonant electro-optic frequency comb. <i>Nature</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41586-019-1110-x\">https://doi.org/10.1038/s41586-019-1110-x</a>"},"intvolume":"       568","arxiv":1,"type":"journal_article","publication":"Nature"},{"publication":"Molecular Biology Reports","type":"journal_article","ddc":["570"],"external_id":{"isi":["000470332600049"]},"acknowledgement":"The studies were supported by the Austrian Federal Ministry of Economy, Family and Youth through the initiative “Laura Bassi Centres of Expertise” funding the Center of Optimized Structural Stud-ies, grant No. 253275","citation":{"ista":"Temnov AA, Rogov KA, Sklifas AN, Klychnikova EV, Hartl M, Djinovic-Carugo K, Charnagalov A. 2019. Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure. Molecular Biology Reports.","short":"A.A. Temnov, K.A. Rogov, A.N. Sklifas, E.V. Klychnikova, M. Hartl, K. Djinovic-Carugo, A. Charnagalov, Molecular Biology Reports (2019).","chicago":"Temnov, Andrey Alexandrovich, Konstantin Arkadevich Rogov, Alla Nikolaevna Sklifas, Elena Valerievna Klychnikova, Markus Hartl, Kristina Djinovic-Carugo, and Alexej Charnagalov. “Protective Properties of the Cultured Stem Cell Proteome Studied in an Animal Model of Acetaminophen-Induced Acute Liver Failure.” <i>Molecular Biology Reports</i>. Springer, 2019. <a href=\"https://doi.org/10.1007/s11033-019-04765-z\">https://doi.org/10.1007/s11033-019-04765-z</a>.","ieee":"A. A. Temnov <i>et al.</i>, “Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure,” <i>Molecular Biology Reports</i>. Springer, 2019.","mla":"Temnov, Andrey Alexandrovich, et al. “Protective Properties of the Cultured Stem Cell Proteome Studied in an Animal Model of Acetaminophen-Induced Acute Liver Failure.” <i>Molecular Biology Reports</i>, Springer, 2019, doi:<a href=\"https://doi.org/10.1007/s11033-019-04765-z\">10.1007/s11033-019-04765-z</a>.","ama":"Temnov AA, Rogov KA, Sklifas AN, et al. Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure. <i>Molecular Biology Reports</i>. 2019. doi:<a href=\"https://doi.org/10.1007/s11033-019-04765-z\">10.1007/s11033-019-04765-z</a>","apa":"Temnov, A. A., Rogov, K. A., Sklifas, A. N., Klychnikova, E. V., Hartl, M., Djinovic-Carugo, K., &#38; Charnagalov, A. (2019). Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure. <i>Molecular Biology Reports</i>. Springer. <a href=\"https://doi.org/10.1007/s11033-019-04765-z\">https://doi.org/10.1007/s11033-019-04765-z</a>"},"quality_controlled":"1","author":[{"first_name":"Andrey Alexandrovich","full_name":"Temnov, Andrey Alexandrovich","last_name":"Temnov"},{"last_name":"Rogov","full_name":"Rogov, Konstantin Arkadevich","first_name":"Konstantin Arkadevich"},{"first_name":"Alla Nikolaevna","full_name":"Sklifas, Alla Nikolaevna","last_name":"Sklifas"},{"full_name":"Klychnikova, Elena Valerievna","first_name":"Elena Valerievna","last_name":"Klychnikova"},{"first_name":"Markus","full_name":"Hartl, Markus","last_name":"Hartl"},{"first_name":"Kristina","full_name":"Djinovic-Carugo, Kristina","last_name":"Djinovic-Carugo"},{"id":"49F06DBA-F248-11E8-B48F-1D18A9856A87","full_name":"Charnagalov, Alexej","first_name":"Alexej","last_name":"Charnagalov"}],"_id":"6352","doi":"10.1007/s11033-019-04765-z","scopus_import":"1","isi":1,"language":[{"iso":"eng"}],"title":"Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure","file_date_updated":"2020-07-14T12:47:28Z","date_created":"2019-04-28T21:59:14Z","abstract":[{"lang":"eng","text":"Chronic overuse of common pharmaceuticals, e.g. acetaminophen (paracetamol), often leads to the development of acute liver failure (ALF). This study aimed to elucidate the effect of cultured mesenchymal stem cells (MSCs) proteome on the onset of liver damage and regeneration dynamics in animals with ALF induced by acetaminophen, to test the liver protective efficacy of MSCs proteome depending on the oxygen tension in cell culture, and to blueprint protein components responsible for the effect. Protein compositions prepared from MSCs cultured in mild hypoxic (5% and 10%  O2) and normal (21%  O2) conditions were used to treat ALF induced in mice by injection of acetaminophen. To test the effect of reduced oxygen tension in cell culture on resulting MSCs proteome content we applied a combination of high performance liquid chromatography and mass-spectrometry (LC–MS/MS) for the identification of proteins in lysates of MSCs cultured at different  O2 levels. The treatment of acetaminophen-administered animals with proteins released from cultured MSCs resulted in the inhibition of inflammatory reactions in damaged liver; the area of hepatocyte necrosis being reduced in the first 24 h. Compositions obtained from MSCs cultured at lower O2 level were shown to be more potent than a composition prepared from normoxic cells. A comparative characterization of protein pattern and identification of individual components done by a cytokine assay and proteomics analysis of protein compositions revealed that even moderate hypoxia produces discrete changes in the expression of various subsets of proteins responsible for intracellular respiration and cell signaling. The application of proteins prepared from MSCs grown in vitro at reduced oxygen tension significantly accelerates healing process in damaged liver tissue. The proteomics data obtained for different preparations offer new information about the potential candidates in the MSCs protein repertoire sensitive to oxygen tension in culture medium, which can be involved in the generalized mechanisms the cells use to respond to acute liver failure."}],"day":"12","publication_identifier":{"eissn":["1573-4978"],"issn":["0301-4851"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","oa_version":"Published Version","file":[{"relation":"main_file","date_created":"2019-04-30T09:52:36Z","file_name":"2019_MolecularBioReport_Temnov.pdf","file_id":"6362","access_level":"open_access","file_size":1948014,"checksum":"45bf040bbce1cea274f6013fa18ba21b","content_type":"application/pdf","creator":"dernst","date_updated":"2020-07-14T12:47:28Z"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"year":"2019","status":"public","corr_author":"1","has_accepted_license":"1","publication_status":"published","date_updated":"2026-04-16T09:49:11Z","month":"04","date_published":"2019-04-12T00:00:00Z","publisher":"Springer","oa":1,"article_processing_charge":"Yes (via OA deal)","department":[{"_id":"LeSa"}]},{"type":"journal_article","publication":"Plant Physiology","citation":{"apa":"Bellstaedt, J., Trenner, J., Lippmann, R., Poeschl, Y., Zhang, X., Friml, J., … Delker, C. (2019). A mobile auxin signal connects temperature sensing in cotyledons with growth responses in hypocotyls. <i>Plant Physiology</i>. ASPB. <a href=\"https://doi.org/10.1104/pp.18.01377\">https://doi.org/10.1104/pp.18.01377</a>","ama":"Bellstaedt J, Trenner J, Lippmann R, et al. A mobile auxin signal connects temperature sensing in cotyledons with growth responses in hypocotyls. <i>Plant Physiology</i>. 2019;180(2):757-766. doi:<a href=\"https://doi.org/10.1104/pp.18.01377\">10.1104/pp.18.01377</a>","ieee":"J. Bellstaedt <i>et al.</i>, “A mobile auxin signal connects temperature sensing in cotyledons with growth responses in hypocotyls,” <i>Plant Physiology</i>, vol. 180, no. 2. ASPB, pp. 757–766, 2019.","mla":"Bellstaedt, Julia, et al. “A Mobile Auxin Signal Connects Temperature Sensing in Cotyledons with Growth Responses in Hypocotyls.” <i>Plant Physiology</i>, vol. 180, no. 2, ASPB, 2019, pp. 757–66, doi:<a href=\"https://doi.org/10.1104/pp.18.01377\">10.1104/pp.18.01377</a>.","chicago":"Bellstaedt, Julia, Jana Trenner, Rebecca Lippmann, Yvonne Poeschl, Xixi Zhang, Jiří Friml, Marcel Quint, and Carolin Delker. “A Mobile Auxin Signal Connects Temperature Sensing in Cotyledons with Growth Responses in Hypocotyls.” <i>Plant Physiology</i>. ASPB, 2019. <a href=\"https://doi.org/10.1104/pp.18.01377\">https://doi.org/10.1104/pp.18.01377</a>.","short":"J. Bellstaedt, J. Trenner, R. Lippmann, Y. Poeschl, X. Zhang, J. Friml, M. Quint, C. Delker, Plant Physiology 180 (2019) 757–766.","ista":"Bellstaedt J, Trenner J, Lippmann R, Poeschl Y, Zhang X, Friml J, Quint M, Delker C. 2019. A mobile auxin signal connects temperature sensing in cotyledons with growth responses in hypocotyls. Plant Physiology. 180(2), 757–766."},"external_id":{"pmid":["31000634"],"isi":["000470086100019"]},"ddc":["580"],"intvolume":"       180","quality_controlled":"1","page":"757-766","author":[{"last_name":"Bellstaedt","full_name":"Bellstaedt, Julia","first_name":"Julia"},{"last_name":"Trenner","first_name":"Jana","full_name":"Trenner, Jana"},{"last_name":"Lippmann","full_name":"Lippmann, Rebecca","first_name":"Rebecca"},{"last_name":"Poeschl","first_name":"Yvonne","full_name":"Poeschl, Yvonne"},{"orcid":"0000-0001-7048-4627","last_name":"Zhang","full_name":"Zhang, Xixi","first_name":"Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596"},{"last_name":"Quint","first_name":"Marcel","full_name":"Quint, Marcel"},{"full_name":"Delker, Carolin","first_name":"Carolin","last_name":"Delker"}],"doi":"10.1104/pp.18.01377","_id":"6366","scopus_import":"1","isi":1,"pmid":1,"title":"A mobile auxin signal connects temperature sensing in cotyledons with growth responses in hypocotyls","main_file_link":[{"url":"www.doi.org/10.1104/pp.18.01377","open_access":"1"}],"language":[{"iso":"eng"}],"volume":180,"abstract":[{"text":"Plants have a remarkable capacity to adjust their growth and development to elevated ambient temperatures. Increased elongation growth of roots, hypocotyls and petioles in warm temperatures are hallmarks of seedling thermomorphogenesis. In the last decade, significant progress has been made to identify the molecular signaling components regulating these growth responses. Increased ambient temperature utilizes diverse components of the light sensing and signal transduction network to trigger growth adjustments. However, it remains unknown whether temperature sensing and responses are universal processes that occur uniformly in all plant organs. Alternatively, temperature sensing may be confined to specific tissues or organs, which would require a systemic signal that mediates responses in distal parts of the plant. Here we show that Arabidopsis (Arabidopsis thaliana) seedlings show organ-specific transcriptome responses to elevated temperatures, and that thermomorphogenesis involves both autonomous and organ-interdependent temperature sensing and signaling. Seedling roots can sense and respond to temperature in a shoot-independent manner, whereas shoot temperature responses require both local and systemic processes. The induction of cell elongation in hypocotyls requires temperature sensing in cotyledons, followed by generation of a mobile auxin signal. Subsequently, auxin travels to the hypocotyl where it triggers local brassinosteroid-induced cell elongation in seedling stems, which depends upon a distinct, permissive temperature sensor in the hypocotyl.","lang":"eng"}],"day":"01","date_created":"2019-04-30T15:24:22Z","publication_identifier":{"issn":["0032-0889"],"eissn":["1532-2548"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","issue":"2","status":"public","year":"2019","article_type":"original","date_published":"2019-06-01T00:00:00Z","month":"06","date_updated":"2026-06-18T19:03:49Z","publication_status":"published","publisher":"ASPB","oa":1,"article_processing_charge":"No","department":[{"_id":"JiFr"}]},{"oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"issn":["1552-4450"],"eissn":["1552-4469"]},"year":"2019","status":"public","issue":"6","publisher":"Springer Nature","date_published":"2019-06-01T00:00:00Z","month":"06","article_type":"original","publication_status":"published","date_updated":"2026-04-08T13:54:44Z","department":[{"_id":"JiFr"}],"article_processing_charge":"No","intvolume":"        15","citation":{"ista":"Dejonghe W, Sharma I, Denoo B, De Munck S, Lu Q, Mishev K, Bulut H, Mylle E, De Rycke R, Vasileva MK, Savatin DV, Nerinckx W, Staes A, Drozdzecki A, Audenaert D, Yperman K, Madder A, Friml J, Van Damme D, Gevaert K, Haucke V, Savvides SN, Winne J, Russinova E. 2019. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. Nature Chemical Biology. 15(6), 641–649.","short":"W. Dejonghe, I. Sharma, B. Denoo, S. De Munck, Q. Lu, K. Mishev, H. Bulut, E. Mylle, R. De Rycke, M.K. Vasileva, D.V. Savatin, W. Nerinckx, A. Staes, A. Drozdzecki, D. Audenaert, K. Yperman, A. Madder, J. Friml, D. Van Damme, K. Gevaert, V. Haucke, S.N. Savvides, J. Winne, E. Russinova, Nature Chemical Biology 15 (2019) 641–649.","chicago":"Dejonghe, Wim, Isha Sharma, Bram Denoo, Steven De Munck, Qing Lu, Kiril Mishev, Haydar Bulut, et al. “Disruption of Endocytosis through Chemical Inhibition of Clathrin Heavy Chain Function.” <i>Nature Chemical Biology</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41589-019-0262-1\">https://doi.org/10.1038/s41589-019-0262-1</a>.","mla":"Dejonghe, Wim, et al. “Disruption of Endocytosis through Chemical Inhibition of Clathrin Heavy Chain Function.” <i>Nature Chemical Biology</i>, vol. 15, no. 6, Springer Nature, 2019, pp. 641–649, doi:<a href=\"https://doi.org/10.1038/s41589-019-0262-1\">10.1038/s41589-019-0262-1</a>.","ieee":"W. Dejonghe <i>et al.</i>, “Disruption of endocytosis through chemical inhibition of clathrin heavy chain function,” <i>Nature Chemical Biology</i>, vol. 15, no. 6. Springer Nature, pp. 641–649, 2019.","ama":"Dejonghe W, Sharma I, Denoo B, et al. Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. <i>Nature Chemical Biology</i>. 2019;15(6):641–649. doi:<a href=\"https://doi.org/10.1038/s41589-019-0262-1\">10.1038/s41589-019-0262-1</a>","apa":"Dejonghe, W., Sharma, I., Denoo, B., De Munck, S., Lu, Q., Mishev, K., … Russinova, E. (2019). Disruption of endocytosis through chemical inhibition of clathrin heavy chain function. <i>Nature Chemical Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41589-019-0262-1\">https://doi.org/10.1038/s41589-019-0262-1</a>"},"external_id":{"isi":["000468195600018"]},"type":"journal_article","publication":"Nature Chemical Biology","doi":"10.1038/s41589-019-0262-1","_id":"6377","page":"641–649","author":[{"first_name":"Wim","full_name":"Dejonghe, Wim","last_name":"Dejonghe"},{"last_name":"Sharma","first_name":"Isha","full_name":"Sharma, Isha"},{"first_name":"Bram","full_name":"Denoo, Bram","last_name":"Denoo"},{"last_name":"De Munck","full_name":"De Munck, Steven","first_name":"Steven"},{"first_name":"Qing","full_name":"Lu, Qing","last_name":"Lu"},{"first_name":"Kiril","full_name":"Mishev, Kiril","last_name":"Mishev"},{"last_name":"Bulut","full_name":"Bulut, Haydar","first_name":"Haydar"},{"full_name":"Mylle, Evelien","first_name":"Evelien","last_name":"Mylle"},{"last_name":"De Rycke","full_name":"De Rycke, Riet","first_name":"Riet"},{"last_name":"Vasileva","id":"3407EB18-F248-11E8-B48F-1D18A9856A87","full_name":"Vasileva, Mina K","first_name":"Mina K"},{"first_name":"Daniel V.","full_name":"Savatin, Daniel V.","last_name":"Savatin"},{"first_name":"Wim","full_name":"Nerinckx, Wim","last_name":"Nerinckx"},{"last_name":"Staes","first_name":"An","full_name":"Staes, An"},{"last_name":"Drozdzecki","first_name":"Andrzej","full_name":"Drozdzecki, Andrzej"},{"last_name":"Audenaert","first_name":"Dominique","full_name":"Audenaert, Dominique"},{"full_name":"Yperman, Klaas","first_name":"Klaas","last_name":"Yperman"},{"last_name":"Madder","first_name":"Annemieke","full_name":"Madder, Annemieke"},{"last_name":"Friml","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří"},{"first_name":"Daniël","full_name":"Van Damme, Daniël","last_name":"Van Damme"},{"last_name":"Gevaert","full_name":"Gevaert, Kris","first_name":"Kris"},{"full_name":"Haucke, Volker","first_name":"Volker","last_name":"Haucke"},{"last_name":"Savvides","first_name":"Savvas N.","full_name":"Savvides, Savvas N."},{"first_name":"Johan","full_name":"Winne, Johan","last_name":"Winne"},{"last_name":"Russinova","full_name":"Russinova, Eugenia","first_name":"Eugenia"}],"quality_controlled":"1","isi":1,"scopus_import":"1","abstract":[{"lang":"eng","text":"Clathrin-mediated endocytosis (CME) is a highly conserved and essential cellular process in eukaryotic cells, but its dynamic and vital nature makes it challenging to study using classical genetics tools. In contrast, although small molecules can acutely and reversibly perturb CME, the few chemical CME inhibitors that have been applied to plants are either ineffective or show undesirable side effects. Here, we identify the previously described endosidin9 (ES9) as an inhibitor of clathrin heavy chain (CHC) function in both Arabidopsis and human cells through affinity-based target isolation, in vitro binding studies and X-ray crystallography. Moreover, we present a chemically improved ES9 analog, ES9-17, which lacks the undesirable side effects of ES9 while retaining the ability to target CHC. ES9 and ES9-17 have expanded the chemical toolbox used to probe CHC function, and present chemical scaffolds for further design of more specific and potent CHC inhibitors across different systems."}],"day":"01","date_created":"2019-05-05T21:59:11Z","volume":15,"title":"Disruption of endocytosis through chemical inhibition of clathrin heavy chain function","language":[{"iso":"eng"}],"related_material":{"record":[{"id":"7172","relation":"dissertation_contains","status":"public"}]}},{"external_id":{"isi":["000466118700002"]},"ddc":["570"],"citation":{"mla":"Moussa, Hagar F., et al. “Canonical PRC1 Controls Sequence-Independent Propagation of Polycomb-Mediated Gene Silencing.” <i>Nature Communications</i>, vol. 10, no. 1, 1931, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-09628-6\">10.1038/s41467-019-09628-6</a>.","ieee":"H. F. Moussa <i>et al.</i>, “Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing,” <i>Nature Communications</i>, vol. 10, no. 1. Springer Nature, 2019.","apa":"Moussa, H. F., Bsteh, D., Yelagandula, R., Pribitzer, C., Stecher, K., Bartalska, K., … Bell, O. (2019). Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-09628-6\">https://doi.org/10.1038/s41467-019-09628-6</a>","ama":"Moussa HF, Bsteh D, Yelagandula R, et al. Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. <i>Nature Communications</i>. 2019;10(1). doi:<a href=\"https://doi.org/10.1038/s41467-019-09628-6\">10.1038/s41467-019-09628-6</a>","ista":"Moussa HF, Bsteh D, Yelagandula R, Pribitzer C, Stecher K, Bartalska K, Michetti L, Wang J, Zepeda-Martinez JA, Elling U, Stuckey JI, James LI, Frye SV, Bell O. 2019. Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing. Nature Communications. 10(1), 1931.","chicago":"Moussa, Hagar F., Daniel Bsteh, Ramesh Yelagandula, Carina Pribitzer, Karin Stecher, Katarina Bartalska, Luca Michetti, et al. “Canonical PRC1 Controls Sequence-Independent Propagation of Polycomb-Mediated Gene Silencing.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-09628-6\">https://doi.org/10.1038/s41467-019-09628-6</a>.","short":"H.F. Moussa, D. Bsteh, R. Yelagandula, C. Pribitzer, K. Stecher, K. Bartalska, L. Michetti, J. Wang, J.A. Zepeda-Martinez, U. Elling, J.I. Stuckey, L.I. James, S.V. Frye, O. Bell, Nature Communications 10 (2019)."},"intvolume":"        10","publication":"Nature Communications","type":"journal_article","_id":"6412","doi":"10.1038/s41467-019-09628-6","quality_controlled":"1","author":[{"last_name":"Moussa","first_name":"Hagar F.","full_name":"Moussa, Hagar F."},{"full_name":"Bsteh, Daniel","first_name":"Daniel","last_name":"Bsteh"},{"last_name":"Yelagandula","full_name":"Yelagandula, Ramesh","first_name":"Ramesh"},{"full_name":"Pribitzer, Carina","first_name":"Carina","last_name":"Pribitzer"},{"full_name":"Stecher, Karin","first_name":"Karin","last_name":"Stecher"},{"full_name":"Bartalska, Katarina","first_name":"Katarina","id":"4D883232-F248-11E8-B48F-1D18A9856A87","last_name":"Bartalska"},{"last_name":"Michetti","full_name":"Michetti, Luca","first_name":"Luca"},{"last_name":"Wang","first_name":"Jingkui","full_name":"Wang, Jingkui"},{"last_name":"Zepeda-Martinez","full_name":"Zepeda-Martinez, Jorge A.","first_name":"Jorge A."},{"full_name":"Elling, Ulrich","first_name":"Ulrich","last_name":"Elling"},{"full_name":"Stuckey, Jacob I.","first_name":"Jacob I.","last_name":"Stuckey"},{"last_name":"James","first_name":"Lindsey I.","full_name":"James, Lindsey I."},{"last_name":"Frye","full_name":"Frye, Stephen V.","first_name":"Stephen V."},{"first_name":"Oliver","full_name":"Bell, Oliver","last_name":"Bell"}],"scopus_import":"1","isi":1,"date_created":"2019-05-13T07:58:35Z","abstract":[{"lang":"eng","text":"Polycomb group (PcG) proteins play critical roles in the epigenetic inheritance of cell fate. The Polycomb Repressive Complexes PRC1 and PRC2 catalyse distinct chromatin modifications to enforce gene silencing, but how transcriptional repression is propagated through mitotic cell divisions remains a key unresolved question. Using reversible tethering of PcG proteins to ectopic sites in mouse embryonic stem cells, here we show that PRC1 can trigger transcriptional repression and Polycomb-dependent chromatin modifications. We find that canonical PRC1 (cPRC1), but not variant PRC1, maintains gene silencing through cell division upon reversal of tethering. Propagation of gene repression is sustained by cis-acting histone modifications, PRC2-mediated H3K27me3 and cPRC1-mediated H2AK119ub1, promoting a sequence-independent feedback mechanism for PcG protein recruitment. Thus, the distinct PRC1 complexes present in vertebrates can differentially regulate epigenetic maintenance of gene silencing, potentially enabling dynamic heritable responses to complex stimuli. Our findings reveal how PcG repression is potentially inherited in vertebrates."}],"day":"29","language":[{"iso":"eng"}],"title":"Canonical PRC1 controls sequence-independent propagation of Polycomb-mediated gene silencing","volume":10,"file_date_updated":"2020-07-14T12:47:29Z","oa_version":"Published Version","file":[{"file_id":"6448","file_name":"2019_NatureComm_Moussa.pdf","date_created":"2019-05-14T08:45:51Z","relation":"main_file","date_updated":"2020-07-14T12:47:29Z","creator":"dernst","file_size":1223647,"content_type":"application/pdf","access_level":"open_access","checksum":"6550a328335396c856db4cbdda7d2994"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"publication_identifier":{"eissn":["2041-1723"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","has_accepted_license":"1","issue":"1","year":"2019","status":"public","publisher":"Springer Nature","publication_status":"published","date_updated":"2026-04-03T09:38:23Z","month":"04","date_published":"2019-04-29T00:00:00Z","article_processing_charge":"No","department":[{"_id":"SaSi"}],"article_number":"1931","oa":1}]