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Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat, Dryad, <a href=\"https://doi.org/10.5061/dryad.8tp0900\">10.5061/dryad.8tp0900</a>.","ama":"Sachdeva H. Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.8tp0900\">10.5061/dryad.8tp0900</a>","apa":"Sachdeva, H. (2019). Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat. Dryad. <a href=\"https://doi.org/10.5061/dryad.8tp0900\">https://doi.org/10.5061/dryad.8tp0900</a>","ieee":"H. Sachdeva, “Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat.” Dryad, 2019.","mla":"Sachdeva, Himani. <i>Data from: Effect of Partial Selfing and Polygenic Selection on Establishment in a New Habitat</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.8tp0900\">10.5061/dryad.8tp0900</a>."},"oa_version":"Published Version","year":"2019","author":[{"last_name":"Sachdeva","id":"42377A0A-F248-11E8-B48F-1D18A9856A87","full_name":"Sachdeva, Himani","first_name":"Himani"}],"status":"public","doi":"10.5061/dryad.8tp0900","_id":"9802","date_published":"2019-07-16T00:00:00Z","month":"07","date_updated":"2024-10-09T20:58:56Z","publisher":"Dryad","title":"Data from: Effect of partial selfing and polygenic selection on establishment in a new habitat","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.8tp0900"}],"oa":1,"related_material":{"record":[{"relation":"used_in_publication","id":"6680","status":"public"}]},"day":"16","abstract":[{"text":"This paper analyzes how partial selfing in a large source population influences its ability to colonize a new habitat via the introduction of a few founder individuals. Founders experience inbreeding depression due to partially recessive deleterious alleles as well as maladaptation to the new environment due to selection on a large number of additive loci. I first introduce a simplified version of the Inbreeding History Model (Kelly, 2007) in order to characterize mutation-selection balance in a large, partially selfing source population under selection involving multiple non-identical loci. I then use individual-based simulations to study the eco-evolutionary dynamics of founders establishing in the new habitat under a model of hard selection. The study explores how selfing rate shapes establishment probabilities of founders via effects on both inbreeding depression and adaptability to the new environment, and also distinguishes the effects of selfing on the initial fitness of founders from its effects on the long-term adaptive response of the populations they found. A high rate of (but not complete) selfing is found to aid establishment over a wide range of parameters, even in the absence of mate limitation. The sensitivity of the results to assumptions about the nature of polygenic selection are discussed.","lang":"eng"}],"article_processing_charge":"No","date_created":"2021-08-06T11:45:11Z","department":[{"_id":"NiBa"}]},{"date_updated":"2026-04-07T13:25:33Z","month":"07","date_published":"2019-07-22T00:00:00Z","publisher":"Dryad","related_material":{"record":[{"status":"public","id":"6831","relation":"used_in_publication"},{"status":"public","relation":"used_in_publication","id":"14058"}]},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.n1701c9"}],"oa":1,"title":"Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics","department":[{"_id":"NiBa"},{"_id":"BeVi"}],"date_created":"2021-08-06T11:48:42Z","day":"22","abstract":[{"text":"Understanding the mechanisms causing phenotypic differences between females and males has long fascinated evolutionary biologists. An extensive literature exists on animal sexual dimorphism but less is known about sex differences in plants, particularly the extent of geographical variation in sexual dimorphism and its life-cycle dynamics. Here, we investigate patterns of genetically-based sexual dimorphism in vegetative and reproductive traits of a wind-pollinated dioecious plant, Rumex hastatulus, across three life-cycle stages using open-pollinated families from 30 populations spanning the geographic range and chromosomal variation (XY and XY1Y2) of the species. The direction and degree of sexual dimorphism was highly variable among populations and life-cycle stages. Sex-specific differences in reproductive function explained a significant amount of temporal change in sexual dimorphism. For several traits, geographical variation in sexual dimorphism was associated with bioclimatic parameters, likely due to the differential responses of the sexes to climate. We found no systematic differences in sexual dimorphism between chromosome races. Sex-specific trait differences in dioecious plants largely result from a balance between sexual and natural selection on resource allocation. Our results indicate that abiotic factors associated with geographical context also play a role in modifying sexual dimorphism during the plant life cycle.","lang":"eng"}],"article_processing_charge":"No","type":"research_data_reference","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","oa_version":"Published Version","citation":{"ista":"Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics, Dryad, <a href=\"https://doi.org/10.5061/dryad.n1701c9\">10.5061/dryad.n1701c9</a>.","short":"G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, (2019).","chicago":"Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett. “Data from: Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle Dynamics.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.n1701c9\">https://doi.org/10.5061/dryad.n1701c9</a>.","mla":"Puixeu Sala, Gemma, et al. <i>Data from: Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle Dynamics</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.n1701c9\">10.5061/dryad.n1701c9</a>.","ieee":"G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics.” Dryad, 2019.","ama":"Puixeu Sala G, Pickup M, Field D, Barrett SCH. Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.n1701c9\">10.5061/dryad.n1701c9</a>","apa":"Puixeu Sala, G., Pickup, M., Field, D., &#38; Barrett, S. C. H. (2019). Data from: Variation in sexual dimorphism in a wind-pollinated plant: the influence of geographical context and life-cycle dynamics. Dryad. <a href=\"https://doi.org/10.5061/dryad.n1701c9\">https://doi.org/10.5061/dryad.n1701c9</a>"},"status":"public","year":"2019","author":[{"orcid":"0000-0001-8330-1754","last_name":"Puixeu Sala","first_name":"Gemma","full_name":"Puixeu Sala, Gemma","id":"33AB266C-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Melinda","full_name":"Pickup, Melinda","id":"2C78037E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6118-0541","last_name":"Pickup"},{"last_name":"Field","full_name":"Field, David","first_name":"David"},{"first_name":"Spencer C.H.","full_name":"Barrett, Spencer C.H.","last_name":"Barrett"}],"_id":"9803","doi":"10.5061/dryad.n1701c9"},{"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","citation":{"mla":"Castro, João Pl, et al. <i>Data from: An Integrative Genomic Analysis of the Longshanks Selection Experiment for Longer Limbs in Mice</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">10.5061/dryad.0q2h6tk</a>.","ieee":"J. P. Castro <i>et al.</i>, “Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice.” Dryad, 2019.","apa":"Castro, J. P., Yancoskie, M. N., Marchini, M., Belohlavy, S., Hiramatsu, L., Kučka, M., … Chan, Y. F. (2019). Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice. Dryad. <a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">https://doi.org/10.5061/dryad.0q2h6tk</a>","ama":"Castro JP, Yancoskie MN, Marchini M, et al. Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">10.5061/dryad.0q2h6tk</a>","ista":"Castro JP, Yancoskie MN, Marchini M, Belohlavy S, Hiramatsu L, Kučka M, Beluch WH, Naumann R, Skuplik I, Cobb J, Barton NH, Rolian C, Chan YF. 2019. Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice, Dryad, <a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">10.5061/dryad.0q2h6tk</a>.","chicago":"Castro, João Pl, Michelle N. Yancoskie, Marta Marchini, Stefanie Belohlavy, Layla Hiramatsu, Marek Kučka, William H. Beluch, et al. “Data from: An Integrative Genomic Analysis of the Longshanks Selection Experiment for Longer Limbs in Mice.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.0q2h6tk\">https://doi.org/10.5061/dryad.0q2h6tk</a>.","short":"J.P. Castro, M.N. Yancoskie, M. Marchini, S. Belohlavy, L. Hiramatsu, M. Kučka, W.H. Beluch, R. Naumann, I. Skuplik, J. Cobb, N.H. Barton, C. Rolian, Y.F. Chan, (2019)."},"oa_version":"Published Version","year":"2019","author":[{"full_name":"Castro, João Pl","first_name":"João Pl","last_name":"Castro"},{"last_name":"Yancoskie","first_name":"Michelle N.","full_name":"Yancoskie, Michelle N."},{"full_name":"Marchini, Marta","first_name":"Marta","last_name":"Marchini"},{"first_name":"Stefanie","full_name":"Belohlavy, Stefanie","id":"43FE426A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9849-498X","last_name":"Belohlavy"},{"first_name":"Layla","full_name":"Hiramatsu, Layla","last_name":"Hiramatsu"},{"last_name":"Kučka","first_name":"Marek","full_name":"Kučka, Marek"},{"first_name":"William H.","full_name":"Beluch, William H.","last_name":"Beluch"},{"first_name":"Ronald","full_name":"Naumann, Ronald","last_name":"Naumann"},{"last_name":"Skuplik","full_name":"Skuplik, Isabella","first_name":"Isabella"},{"last_name":"Cobb","first_name":"John","full_name":"Cobb, John"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H","first_name":"Nicholas H","last_name":"Barton","orcid":"0000-0002-8548-5240"},{"full_name":"Rolian, Campbell","first_name":"Campbell","last_name":"Rolian"},{"last_name":"Chan","first_name":"Yingguang Frank","full_name":"Chan, Yingguang Frank"}],"status":"public","doi":"10.5061/dryad.0q2h6tk","_id":"9804","month":"06","date_published":"2019-06-06T00:00:00Z","date_updated":"2023-08-29T06:41:51Z","publisher":"Dryad","title":"Data from: An integrative genomic analysis of the Longshanks selection experiment for longer limbs in mice","related_material":{"record":[{"status":"public","id":"6713","relation":"used_in_publication"}]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.5061/dryad.0q2h6tk","open_access":"1"}],"department":[{"_id":"NiBa"}],"day":"06","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Evolutionary studies are often limited by missing data that are critical to understanding the history of selection. Selection experiments, which reproduce rapid evolution under controlled conditions, are excellent tools to study how genomes evolve under selection. Here we present a genomic dissection of the Longshanks selection experiment, in which mice were selectively bred over 20 generations for longer tibiae relative to body mass, resulting in 13% longer tibiae in two replicates. We synthesized evolutionary theory, genome sequences and molecular genetics to understand the selection response and found that it involved both polygenic adaptation and discrete loci of major effect, with the strongest loci tending to be selected in parallel between replicates. We show that selection may favor de-repression of bone growth through inactivating two limb enhancers of an inhibitor, Nkx3-2. Our integrative genomic analyses thus show that it is possible to connect individual base-pair changes to the overall selection response."}],"date_created":"2021-08-06T11:52:54Z"},{"author":[{"orcid":"0000-0002-8548-5240","last_name":"Barton","full_name":"Barton, Nicholas H","first_name":"Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87"}],"year":"2019","status":"public","doi":"10.5061/dryad.2kb6fh4","_id":"9805","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","citation":{"ama":"Barton NH. Data from: The consequences of an introgression event. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">10.5061/dryad.2kb6fh4</a>","apa":"Barton, N. H. (2019). Data from: The consequences of an introgression event. Dryad. <a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">https://doi.org/10.5061/dryad.2kb6fh4</a>","ieee":"N. H. Barton, “Data from: The consequences of an introgression event.” Dryad, 2019.","mla":"Barton, Nicholas H. <i>Data from: The Consequences of an Introgression Event</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">10.5061/dryad.2kb6fh4</a>.","short":"N.H. Barton, (2019).","chicago":"Barton, Nicholas H. “Data from: The Consequences of an Introgression Event.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">https://doi.org/10.5061/dryad.2kb6fh4</a>.","ista":"Barton NH. 2019. Data from: The consequences of an introgression event, Dryad, <a href=\"https://doi.org/10.5061/dryad.2kb6fh4\">10.5061/dryad.2kb6fh4</a>."},"oa_version":"Published Version","title":"Data from: The consequences of an introgression event","related_material":{"record":[{"status":"public","relation":"used_in_publication","id":"40"}]},"oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.2kb6fh4"}],"department":[{"_id":"NiBa"}],"article_processing_charge":"No","abstract":[{"text":"The spread of adaptive alleles is fundamental to evolution, and in theory, this process is well‐understood. However, only rarely can we follow this process—whether it originates from the spread of a new mutation, or by introgression from another population. In this issue of Molecular Ecology, Hanemaaijer et al. (2018) report on a 25‐year long study of the mosquitoes Anopheles gambiae (Figure 1) and Anopheles coluzzi in Mali, based on genotypes at 15 single‐nucleotide polymorphism (SNP). The species are usually reproductively isolated from each other, but in 2002 and 2006, bursts of hybridization were observed, when F1 hybrids became abundant. Alleles backcrossed from A. gambiae into A. coluzzi, but after the first event, these declined over the following years. In contrast, after 2006, an insecticide resistance allele that had established in A. gambiae spread into A. coluzzi, and rose to high frequency there, over 6 years (~75 generations). Whole genome sequences of 74 individuals showed that A. gambiae SNP from across the genome had become common in the A. coluzzi population, but that most of these were clustered in 34 genes around the resistance locus. A new set of SNP from 25 of these genes were assayed over time; over the 4 years since near‐fixation of the resistance allele; some remained common, whereas others declined. What do these patterns tell us about this introgression event?","lang":"eng"}],"day":"09","date_created":"2021-08-06T12:03:50Z","month":"01","date_published":"2019-01-09T00:00:00Z","date_updated":"2025-07-10T11:52:34Z","publisher":"Dryad"},{"month":"02","date_published":"2019-02-05T00:00:00Z","date_updated":"2025-07-10T11:53:11Z","publisher":"Dryad","title":"Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance","related_material":{"record":[{"status":"public","id":"6105","relation":"used_in_publication"}]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.5061/dryad.9kj41f0","open_access":"1"}],"department":[{"_id":"SyCr"}],"article_processing_charge":"No","abstract":[{"text":"1. Hosts can alter their strategy towards pathogens during their lifetime, i.e., they can show phenotypic plasticity in immunity or life history. Immune priming is one such example, where a previous encounter with a pathogen confers enhanced protection upon secondary challenge, resulting in reduced pathogen load (i.e. resistance) and improved host survival. However, an initial encounter might also enhance tolerance, particularly to less virulent opportunistic pathogens that establish persistent infections. In this scenario, individuals are better able to reduce the negative fitness consequences that result from a high pathogen load. Finally, previous exposure may also lead to life history adjustments, such as terminal investment into reproduction. 2. Using different Drosophila melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas entomophila, we tested if previous exposure results in resistance or tolerance and whether it modifies immune gene expression during an acute-phase infection (one day post-challenge). We then asked if previous pathogen exposure affects chronic-phase pathogen persistence and longer-term survival (28 days post-challenge). 3. We predicted that previous exposure would increase host resistance to an early stage bacterial infection while it might come at a cost to host fecundity tolerance. We reasoned that resistance would be due in part to stronger immune gene expression after challenge. We expected that previous exposure would improve long-term survival, that it would reduce infection persistence, and we expected to find genetic variation in these responses. 4. We found that previous exposure to P. entomophila weakened host resistance to a second infection independent of genotype and had no effect on immune gene expression. Fecundity tolerance showed genotypic variation but was not influenced by previous exposure. However, L. lactis persisted as a chronic infection, whereas survivors cleared the more pathogenic P. entomophila infection. 5. To our knowledge, this is the first study that addresses host tolerance to bacteria in relation to previous exposure, taking a multi-faceted approach to address the topic. Our results suggest that previous exposure comes with transient costs to resistance during the early stage of infection in this host-pathogen system and that infection persistence may be bacterium-specific.","lang":"eng"}],"day":"05","date_created":"2021-08-06T12:06:40Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","citation":{"mla":"Kutzer, Megan, et al. <i>Data from: A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.9kj41f0\">10.5061/dryad.9kj41f0</a>.","ieee":"M. Kutzer, J. Kurtz, and S. A. O. Armitage, “Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance.” Dryad, 2019.","ama":"Kutzer M, Kurtz J, Armitage SAO. Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.9kj41f0\">10.5061/dryad.9kj41f0</a>","apa":"Kutzer, M., Kurtz, J., &#38; Armitage, S. A. O. (2019). Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Dryad. <a href=\"https://doi.org/10.5061/dryad.9kj41f0\">https://doi.org/10.5061/dryad.9kj41f0</a>","ista":"Kutzer M, Kurtz J, Armitage SAO. 2019. Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance, Dryad, <a href=\"https://doi.org/10.5061/dryad.9kj41f0\">10.5061/dryad.9kj41f0</a>.","short":"M. Kutzer, J. Kurtz, S.A.O. Armitage, (2019).","chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “Data from: A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.9kj41f0\">https://doi.org/10.5061/dryad.9kj41f0</a>."},"oa_version":"Published Version","status":"public","author":[{"full_name":"Kutzer, Megan","first_name":"Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8696-6978","last_name":"Kutzer"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"},{"full_name":"Armitage, Sophie A.O.","first_name":"Sophie A.O.","last_name":"Armitage"}],"year":"2019","doi":"10.5061/dryad.9kj41f0","_id":"9806"},{"doi":"10.5061/dryad.5vv37","_id":"9839","year":"2019","author":[{"orcid":"0000-0003-0951-3112","last_name":"Polechova","full_name":"Polechova, Jitka","first_name":"Jitka","id":"3BBFB084-F248-11E8-B48F-1D18A9856A87"}],"status":"public","citation":{"mla":"Polechova, Jitka. <i>Data from: Is the Sky the Limit? On the Expansion Threshold of a Species’ Range</i>. Dryad, 2019, doi:<a href=\"https://doi.org/10.5061/dryad.5vv37\">10.5061/dryad.5vv37</a>.","ieee":"J. Polechova, “Data from: Is the sky the limit? On the expansion threshold of a species’ range.” Dryad, 2019.","apa":"Polechova, J. (2019). Data from: Is the sky the limit? On the expansion threshold of a species’ range. Dryad. <a href=\"https://doi.org/10.5061/dryad.5vv37\">https://doi.org/10.5061/dryad.5vv37</a>","ama":"Polechova J. Data from: Is the sky the limit? On the expansion threshold of a species’ range. 2019. doi:<a href=\"https://doi.org/10.5061/dryad.5vv37\">10.5061/dryad.5vv37</a>","ista":"Polechova J. 2019. Data from: Is the sky the limit? On the expansion threshold of a species’ range, Dryad, <a href=\"https://doi.org/10.5061/dryad.5vv37\">10.5061/dryad.5vv37</a>.","chicago":"Polechova, Jitka. “Data from: Is the Sky the Limit? On the Expansion Threshold of a Species’ Range.” Dryad, 2019. <a href=\"https://doi.org/10.5061/dryad.5vv37\">https://doi.org/10.5061/dryad.5vv37</a>.","short":"J. Polechova, (2019)."},"oa_version":"Published Version","type":"research_data_reference","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","day":"22","abstract":[{"lang":"eng","text":"More than 100 years after Grigg’s influential analysis of species’ borders, the causes of limits to species’ ranges still represent a puzzle that has never been understood with clarity. The topic has become especially important recently as many scientists have become interested in the potential for species’ ranges to shift in response to climate change—and yet nearly all of those studies fail to recognise or incorporate evolutionary genetics in a way that relates to theoretical developments. I show that range margins can be understood based on just two measurable parameters: (i) the fitness cost of dispersal—a measure of environmental heterogeneity—and (ii) the strength of genetic drift, which reduces genetic diversity. Together, these two parameters define an ‘expansion threshold’: adaptation fails when genetic drift reduces genetic diversity below that required for adaptation to a heterogeneous environment. When the key parameters drop below this expansion threshold locally, a sharp range margin forms. When they drop below this threshold throughout the species’ range, adaptation collapses everywhere, resulting in either extinction or formation of a fragmented metapopulation. Because the effects of dispersal differ fundamentally with dimension, the second parameter—the strength of genetic drift—is qualitatively different compared to a linear habitat. In two-dimensional habitats, genetic drift becomes effectively independent of selection. It decreases with ‘neighbourhood size’—the number of individuals accessible by dispersal within one generation. Moreover, in contrast to earlier predictions, which neglected evolution of genetic variance and/or stochasticity in two dimensions, dispersal into small marginal populations aids adaptation. This is because the reduction of both genetic and demographic stochasticity has a stronger effect than the cost of dispersal through increased maladaptation. The expansion threshold thus provides a novel, theoretically justified, and testable prediction for formation of the range margin and collapse of the species’ range."}],"article_processing_charge":"No","date_created":"2021-08-09T13:07:28Z","department":[{"_id":"NiBa"}],"title":"Data from: Is the sky the limit? On the expansion threshold of a species' range","main_file_link":[{"url":"https://doi.org/10.5061/dryad.5vv37","open_access":"1"}],"oa":1,"related_material":{"record":[{"status":"public","id":"315","relation":"used_in_publication"}]},"publisher":"Dryad","month":"06","date_published":"2019-06-22T00:00:00Z","date_updated":"2025-07-10T11:52:26Z"},{"type":"journal_article","publication":"PLoS Genetics","intvolume":"        15","citation":{"ieee":"V. Pokusaeva <i>et al.</i>, “An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape,” <i>PLoS Genetics</i>, vol. 15, no. 4. Public Library of Science, 2019.","mla":"Pokusaeva, Victoria, et al. “An Experimental Assay of the Interactions of Amino Acids from Orthologous Sequences Shaping a Complex Fitness Landscape.” <i>PLoS Genetics</i>, vol. 15, no. 4, e1008079, Public Library of Science, 2019, doi:<a href=\"https://doi.org/10.1371/journal.pgen.1008079\">10.1371/journal.pgen.1008079</a>.","apa":"Pokusaeva, V., Usmanova, D. R., Putintseva, E. V., Espinar, L., Sarkisyan, K., Mishin, A. S., … Kondrashov, F. (2019). An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape. <i>PLoS Genetics</i>. Public Library of Science. <a href=\"https://doi.org/10.1371/journal.pgen.1008079\">https://doi.org/10.1371/journal.pgen.1008079</a>","ama":"Pokusaeva V, Usmanova DR, Putintseva EV, et al. An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape. <i>PLoS Genetics</i>. 2019;15(4). doi:<a href=\"https://doi.org/10.1371/journal.pgen.1008079\">10.1371/journal.pgen.1008079</a>","ista":"Pokusaeva V, Usmanova DR, Putintseva EV, Espinar L, Sarkisyan K, Mishin AS, Bogatyreva NS, Ivankov D, Akopyan A, Avvakumov S, Povolotskaya IS, Filion GJ, Carey LB, Kondrashov F. 2019. An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape. PLoS Genetics. 15(4), e1008079.","chicago":"Pokusaeva, Victoria, Dinara R. Usmanova, Ekaterina V. Putintseva, Lorena Espinar, Karen Sarkisyan, Alexander S. Mishin, Natalya S. Bogatyreva, et al. “An Experimental Assay of the Interactions of Amino Acids from Orthologous Sequences Shaping a Complex Fitness Landscape.” <i>PLoS Genetics</i>. Public Library of Science, 2019. <a href=\"https://doi.org/10.1371/journal.pgen.1008079\">https://doi.org/10.1371/journal.pgen.1008079</a>.","short":"V. Pokusaeva, D.R. Usmanova, E.V. Putintseva, L. Espinar, K. Sarkisyan, A.S. Mishin, N.S. Bogatyreva, D. Ivankov, A. Akopyan, S. Avvakumov, I.S. Povolotskaya, G.J. Filion, L.B. Carey, F. Kondrashov, PLoS Genetics 15 (2019)."},"external_id":{"isi":["000466866000029"]},"ddc":["570"],"author":[{"full_name":"Pokusaeva, Victoria","first_name":"Victoria","id":"3184041C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7660-444X","last_name":"Pokusaeva"},{"last_name":"Usmanova","first_name":"Dinara R.","full_name":"Usmanova, Dinara R."},{"first_name":"Ekaterina V.","full_name":"Putintseva, Ekaterina V.","last_name":"Putintseva"},{"last_name":"Espinar","full_name":"Espinar, Lorena","first_name":"Lorena"},{"full_name":"Sarkisyan, Karen","first_name":"Karen","id":"39A7BF80-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-5375-6341","last_name":"Sarkisyan"},{"full_name":"Mishin, Alexander S.","first_name":"Alexander S.","last_name":"Mishin"},{"full_name":"Bogatyreva, Natalya S.","first_name":"Natalya S.","last_name":"Bogatyreva"},{"orcid":"0000-0002-8224-4118","last_name":"Ivankov","full_name":"Ivankov, Dmitry","first_name":"Dmitry","id":"49FF1036-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Akopyan","orcid":"0000-0002-2548-617X","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","first_name":"Arseniy","full_name":"Akopyan, Arseniy"},{"id":"3827DAC8-F248-11E8-B48F-1D18A9856A87","first_name":"Sergey","full_name":"Avvakumov, Sergey","last_name":"Avvakumov","orcid":"0000-0002-7840-5062"},{"first_name":"Inna S.","full_name":"Povolotskaya, Inna S.","last_name":"Povolotskaya"},{"first_name":"Guillaume J.","full_name":"Filion, Guillaume J.","last_name":"Filion"},{"full_name":"Carey, Lucas B.","first_name":"Lucas B.","last_name":"Carey"},{"last_name":"Kondrashov","orcid":"0000-0001-8243-4694","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","full_name":"Kondrashov, Fyodor","first_name":"Fyodor"}],"quality_controlled":"1","project":[{"call_identifier":"H2020","grant_number":"665385","name":"International IST Doctoral Program","_id":"2564DBCA-B435-11E9-9278-68D0E5697425"}],"doi":"10.1371/journal.pgen.1008079","_id":"6419","isi":1,"scopus_import":"1","file_date_updated":"2020-07-14T12:47:30Z","volume":15,"title":"An experimental assay of the interactions of amino acids from orthologous sequences shaping a complex fitness landscape","related_material":{"record":[{"relation":"research_data","id":"9789","status":"public"},{"relation":"research_data","id":"9790","status":"public"},{"id":"9797","relation":"research_data","status":"public"}]},"language":[{"iso":"eng"}],"abstract":[{"text":"Characterizing the fitness landscape, a representation of fitness for a large set of genotypes, is key to understanding how genetic information is interpreted to create functional organisms. Here we determined the evolutionarily-relevant segment of the fitness landscape of His3, a gene coding for an enzyme in the histidine synthesis pathway, focusing on combinations of amino acid states found at orthologous sites of extant species. Just 15% of amino acids found in yeast His3 orthologues were always neutral while the impact on fitness of the remaining 85% depended on the genetic background. Furthermore, at 67% of sites, amino acid replacements were under sign epistasis, having both strongly positive and negative effect in different genetic backgrounds. 46% of sites were under reciprocal sign epistasis. The fitness impact of amino acid replacements was influenced by only a few genetic backgrounds but involved interaction of multiple sites, shaping a rugged fitness landscape in which many of the shortest paths between highly fit genotypes are inaccessible.","lang":"eng"}],"day":"10","date_created":"2019-05-13T07:58:38Z","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_identifier":{"eissn":["1553-7404"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"file":[{"file_name":"2019_PLOSGenetics_Pokusaeva.pdf","date_created":"2019-05-14T08:26:08Z","relation":"main_file","file_id":"6445","creator":"dernst","access_level":"open_access","content_type":"application/pdf","file_size":3726017,"checksum":"cf3889c8a8a16053dacf9c3776cbe217","date_updated":"2020-07-14T12:47:30Z"}],"oa_version":"Published Version","status":"public","year":"2019","issue":"4","has_accepted_license":"1","month":"04","date_published":"2019-04-10T00:00:00Z","publication_status":"published","date_updated":"2026-04-03T09:45:19Z","ec_funded":1,"publisher":"Public Library of Science","oa":1,"article_number":"e1008079","department":[{"_id":"FyKo"}],"article_processing_charge":"No"},{"has_accepted_license":"1","status":"public","year":"2019","file":[{"file_id":"8633","relation":"main_file","date_created":"2020-10-08T17:25:45Z","file_name":"2019_ACM_Ferrere.pdf","date_updated":"2020-10-08T17:25:45Z","success":1,"file_size":1055421,"content_type":"application/pdf","access_level":"open_access","checksum":"b8e967081e051d1c55ca5d18fb187890","creator":"dernst"}],"oa_version":"Submitted Version","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_identifier":{"isbn":["9781450362825"]},"department":[{"_id":"ToHe"}],"conference":{"location":"Montreal, Canada","end_date":"2019-04-18","name":"HSCC: Hybrid Systems - Computation and Control","start_date":"2019-04-16"},"article_processing_charge":"No","oa":1,"publisher":"ACM","month":"04","date_published":"2019-04-16T00:00:00Z","publication_status":"published","date_updated":"2025-07-10T11:53:22Z","project":[{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","grant_number":"S 11407_N23","call_identifier":"FWF"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"Z211","name":"Formal methods for the design and analysis of complex systems"}],"doi":"10.1145/3302504.3311800","_id":"6428","author":[{"last_name":"Ferrere","orcid":"0000-0001-5199-3143","id":"40960E6E-F248-11E8-B48F-1D18A9856A87","first_name":"Thomas","full_name":"Ferrere, Thomas"},{"last_name":"Nickovic","first_name":"Dejan","full_name":"Nickovic, Dejan","id":"41BCEE5C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Donzé, Alexandre","first_name":"Alexandre","last_name":"Donzé"},{"full_name":"Ito, Hisahiro","first_name":"Hisahiro","last_name":"Ito"},{"last_name":"Kapinski","first_name":"James","full_name":"Kapinski, James"}],"page":"57-66","quality_controlled":"1","citation":{"short":"T. Ferrere, D. Nickovic, A. Donzé, H. Ito, J. Kapinski, in:, Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control, ACM, 2019, pp. 57–66.","chicago":"Ferrere, Thomas, Dejan Nickovic, Alexandre Donzé, Hisahiro Ito, and James Kapinski. “Interface-Aware Signal Temporal Logic.” In <i>Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control</i>, 57–66. ACM, 2019. <a href=\"https://doi.org/10.1145/3302504.3311800\">https://doi.org/10.1145/3302504.3311800</a>.","ista":"Ferrere T, Nickovic D, Donzé A, Ito H, Kapinski J. 2019. Interface-aware signal temporal logic. Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control. HSCC: Hybrid Systems - Computation and Control, 57–66.","ama":"Ferrere T, Nickovic D, Donzé A, Ito H, Kapinski J. Interface-aware signal temporal logic. In: <i>Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control</i>. ACM; 2019:57-66. doi:<a href=\"https://doi.org/10.1145/3302504.3311800\">10.1145/3302504.3311800</a>","apa":"Ferrere, T., Nickovic, D., Donzé, A., Ito, H., &#38; Kapinski, J. (2019). Interface-aware signal temporal logic. In <i>Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control</i> (pp. 57–66). Montreal, Canada: ACM. <a href=\"https://doi.org/10.1145/3302504.3311800\">https://doi.org/10.1145/3302504.3311800</a>","ieee":"T. Ferrere, D. Nickovic, A. Donzé, H. Ito, and J. Kapinski, “Interface-aware signal temporal logic,” in <i>Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control</i>, Montreal, Canada, 2019, pp. 57–66.","mla":"Ferrere, Thomas, et al. “Interface-Aware Signal Temporal Logic.” <i>Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control</i>, ACM, 2019, pp. 57–66, doi:<a href=\"https://doi.org/10.1145/3302504.3311800\">10.1145/3302504.3311800</a>."},"ddc":["000"],"external_id":{"isi":["000516713900007"]},"publication":"Proceedings of the 2019 22nd ACM International Conference on Hybrid Systems: Computation and Control","type":"conference","abstract":[{"text":"Safety and security are major concerns in the development of Cyber-Physical Systems (CPS). Signal temporal logic (STL) was proposedas a language to specify and monitor the correctness of CPS relativeto formalized requirements. Incorporating STL into a developmentprocess enables designers to automatically monitor and diagnosetraces, compute robustness estimates based on requirements, andperform requirement falsification, leading to productivity gains inverification and validation activities; however, in its current formSTL is agnostic to the input/output classification of signals, andthis negatively impacts the relevance of the analysis results.In this paper we propose to make the interface explicit in theSTL language by introducing input/output signal declarations. Wethen define new measures of input vacuity and output robustnessthat better reflect the nature of the system and the specification in-tent. The resulting framework, which we call interface-aware signaltemporal logic (IA-STL), aids verification and validation activities.We demonstrate the benefits of IA-STL on several CPS analysisactivities: (1) robustness-driven sensitivity analysis, (2) falsificationand (3) fault localization. We describe an implementation of our en-hancement to STL and associated notions of robustness and vacuityin a prototype extension of Breach, a MATLAB®/Simulink®toolboxfor CPS verification and validation. We explore these methodologi-cal improvements and evaluate our results on two examples fromthe automotive domain: a benchmark powertrain control systemand a hydrogen fuel cell system.","lang":"eng"}],"day":"16","date_created":"2019-05-13T08:13:46Z","file_date_updated":"2020-10-08T17:25:45Z","title":"Interface-aware signal temporal logic","language":[{"iso":"eng"}],"isi":1,"scopus_import":"1"},{"project":[{"_id":"258AA5B2-B435-11E9-9278-68D0E5697425","grant_number":"682815","call_identifier":"H2020","name":"Teaching Old Crypto New Tricks"}],"doi":"10.1007/978-3-030-17259-6_11","_id":"6430","author":[{"last_name":"Fuchsbauer","id":"46B4C3EE-F248-11E8-B48F-1D18A9856A87","full_name":"Fuchsbauer, Georg","first_name":"Georg"},{"id":"4BD3F30E-F248-11E8-B48F-1D18A9856A87","first_name":"Chethan","full_name":"Kamath Hosdurg, Chethan","last_name":"Kamath Hosdurg","orcid":"0009-0006-6812-7317"},{"id":"3E83A2F8-F248-11E8-B48F-1D18A9856A87","full_name":"Klein, Karen","first_name":"Karen","last_name":"Klein"},{"id":"3E04A7AA-F248-11E8-B48F-1D18A9856A87","full_name":"Pietrzak, Krzysztof Z","first_name":"Krzysztof Z","last_name":"Pietrzak","orcid":"0000-0002-9139-1654"}],"page":"317-346","quality_controlled":"1","intvolume":"     11443","citation":{"apa":"Fuchsbauer, G., Kamath Hosdurg, C., Klein, K., &#38; Pietrzak, K. Z. (2019). Adaptively secure proxy re-encryption (Vol. 11443, pp. 317–346). Presented at the PKC: Public-Key Cryptograhy, Beijing, China: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-030-17259-6_11\">https://doi.org/10.1007/978-3-030-17259-6_11</a>","ama":"Fuchsbauer G, Kamath Hosdurg C, Klein K, Pietrzak KZ. Adaptively secure proxy re-encryption. In: Vol 11443. Springer Nature; 2019:317-346. doi:<a href=\"https://doi.org/10.1007/978-3-030-17259-6_11\">10.1007/978-3-030-17259-6_11</a>","mla":"Fuchsbauer, Georg, et al. <i>Adaptively Secure Proxy Re-Encryption</i>. Vol. 11443, Springer Nature, 2019, pp. 317–46, doi:<a href=\"https://doi.org/10.1007/978-3-030-17259-6_11\">10.1007/978-3-030-17259-6_11</a>.","ieee":"G. Fuchsbauer, C. Kamath Hosdurg, K. Klein, and K. Z. Pietrzak, “Adaptively secure proxy re-encryption,” presented at the PKC: Public-Key Cryptograhy, Beijing, China, 2019, vol. 11443, pp. 317–346.","chicago":"Fuchsbauer, Georg, Chethan Kamath Hosdurg, Karen Klein, and Krzysztof Z Pietrzak. “Adaptively Secure Proxy Re-Encryption,” 11443:317–46. Springer Nature, 2019. <a href=\"https://doi.org/10.1007/978-3-030-17259-6_11\">https://doi.org/10.1007/978-3-030-17259-6_11</a>.","short":"G. Fuchsbauer, C. Kamath Hosdurg, K. Klein, K.Z. Pietrzak, in:, Springer Nature, 2019, pp. 317–346.","ista":"Fuchsbauer G, Kamath Hosdurg C, Klein K, Pietrzak KZ. 2019. Adaptively secure proxy re-encryption. PKC: Public-Key Cryptograhy, LNCS, vol. 11443, 317–346."},"external_id":{"isi":["001299215500011"]},"type":"conference","abstract":[{"text":"A proxy re-encryption (PRE) scheme is a public-key encryption scheme that allows the holder of a key pk to derive a re-encryption key for any other key 𝑝𝑘′. This re-encryption key lets anyone transform ciphertexts under pk into ciphertexts under 𝑝𝑘′ without having to know the underlying message, while transformations from 𝑝𝑘′ to pk should not be possible (unidirectional). Security is defined in a multi-user setting against an adversary that gets the users’ public keys and can ask for re-encryption keys and can corrupt users by requesting their secret keys. Any ciphertext that the adversary cannot trivially decrypt given the obtained secret and re-encryption keys should be secure.\r\n\r\nAll existing security proofs for PRE only show selective security, where the adversary must first declare the users it wants to corrupt. This can be lifted to more meaningful adaptive security by guessing the set of corrupted users among the n users, which loses a factor exponential in  Open image in new window , rendering the result meaningless already for moderate Open image in new window .\r\n\r\nJafargholi et al. (CRYPTO’17) proposed a framework that in some cases allows to give adaptive security proofs for schemes which were previously only known to be selectively secure, while avoiding the exponential loss that results from guessing the adaptive choices made by an adversary. We apply their framework to PREs that satisfy some natural additional properties. Concretely, we give a more fine-grained reduction for several unidirectional PREs, proving adaptive security at a much smaller loss. The loss depends on the graph of users whose edges represent the re-encryption keys queried by the adversary. For trees and chains the loss is quasi-polynomial in the size and for general graphs it is exponential in their depth and indegree (instead of their size as for previous reductions). Fortunately, trees and low-depth graphs cover many, if not most, interesting applications.\r\n\r\nOur results apply e.g. to the bilinear-map based PRE schemes by Ateniese et al. (NDSS’05 and CT-RSA’09), Gentry’s FHE-based scheme (STOC’09) and the LWE-based scheme by Chandran et al. (PKC’14).","lang":"eng"}],"day":"06","date_created":"2019-05-13T08:13:46Z","volume":11443,"title":"Adaptively secure proxy re-encryption","main_file_link":[{"open_access":"1","url":"https://eprint.iacr.org/2018/426"}],"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"10035"}]},"language":[{"iso":"eng"}],"isi":1,"scopus_import":"1","year":"2019","status":"public","alternative_title":["LNCS"],"oa_version":"Preprint","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_identifier":{"eissn":["1611-3349"],"isbn":["9783030172589"],"issn":["0302-9743"]},"department":[{"_id":"KrPi"}],"conference":{"start_date":"2019-04-14","name":"PKC: Public-Key Cryptograhy","end_date":"2019-04-17","location":"Beijing, China"},"article_processing_charge":"No","oa":1,"ec_funded":1,"publisher":"Springer Nature","month":"04","date_published":"2019-04-06T00:00:00Z","publication_status":"published","date_updated":"2026-04-16T09:52:04Z"},{"department":[{"_id":"ChWo"}],"article_number":"130","article_processing_charge":"No","oa":1,"ec_funded":1,"publisher":"ACM","acknowledged_ssus":[{"_id":"ScienComp"}],"date_published":"2019-07-01T00:00:00Z","month":"07","publication_status":"published","date_updated":"2024-10-22T09:58:22Z","has_accepted_license":"1","issue":"4","year":"2019","status":"public","file":[{"file_id":"6443","file_name":"2019_ACM_Schreck.pdf","date_created":"2019-05-14T07:03:55Z","relation":"main_file","date_updated":"2020-07-14T12:47:30Z","creator":"dernst","file_size":44328918,"content_type":"application/pdf","access_level":"open_access","checksum":"1b737dfe3e051aba8f3f4ab1dceda673"}],"oa_version":"Submitted Version","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"text":"This paper investigates the use of fundamental solutions for animating detailed linear water surface waves. We first propose an analytical solution for efficiently animating circular ripples in closed form. We then show how to adapt the method of fundamental solutions (MFS) to create ambient waves interacting with complex obstacles. Subsequently, we present a novel wavelet-based discretization which outperforms the state of the art MFS approach for simulating time-varying water surface waves with moving obstacles. Our results feature high-resolution spatial details, interactions with complex boundaries, and large open ocean domains. Our method compares favorably with previous work as well as known analytical solutions. We also present comparisons between our method and real world examples.","lang":"eng"}],"day":"01","date_created":"2019-05-14T07:04:06Z","file_date_updated":"2020-07-14T12:47:30Z","volume":38,"title":"Fundamental solutions for water wave animation","language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/new-method-makes-realistic-water-wave-animations-more-efficient/","description":"News on IST Homepage","relation":"press_release"}]},"isi":1,"scopus_import":"1","project":[{"_id":"2533E772-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"638176","name":"Big Splash: Efficient Simulation of Natural Phenomena at Extremely Large Scales"},{"grant_number":"715767","call_identifier":"H2020","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling","_id":"24F9549A-B435-11E9-9278-68D0E5697425"},{"_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","grant_number":"665385","call_identifier":"H2020"}],"doi":"10.1145/3306346.3323002","_id":"6442","author":[{"last_name":"Schreck","full_name":"Schreck, Camille","first_name":"Camille","id":"2B14B676-F248-11E8-B48F-1D18A9856A87"},{"id":"400429CC-F248-11E8-B48F-1D18A9856A87","full_name":"Hafner, Christian","first_name":"Christian","last_name":"Hafner"},{"id":"3C61F1D2-F248-11E8-B48F-1D18A9856A87","full_name":"Wojtan, Christopher J","first_name":"Christopher J","last_name":"Wojtan","orcid":"0000-0001-6646-5546"}],"quality_controlled":"1","intvolume":"        38","citation":{"ista":"Schreck C, Hafner C, Wojtan C. 2019. Fundamental solutions for water wave animation. ACM Transactions on Graphics. 38(4), 130.","chicago":"Schreck, Camille, Christian Hafner, and Chris Wojtan. “Fundamental Solutions for Water Wave Animation.” <i>ACM Transactions on Graphics</i>. ACM, 2019. <a href=\"https://doi.org/10.1145/3306346.3323002\">https://doi.org/10.1145/3306346.3323002</a>.","short":"C. Schreck, C. Hafner, C. Wojtan, ACM Transactions on Graphics 38 (2019).","ieee":"C. Schreck, C. Hafner, and C. Wojtan, “Fundamental solutions for water wave animation,” <i>ACM Transactions on Graphics</i>, vol. 38, no. 4. ACM, 2019.","mla":"Schreck, Camille, et al. “Fundamental Solutions for Water Wave Animation.” <i>ACM Transactions on Graphics</i>, vol. 38, no. 4, 130, ACM, 2019, doi:<a href=\"https://doi.org/10.1145/3306346.3323002\">10.1145/3306346.3323002</a>.","apa":"Schreck, C., Hafner, C., &#38; Wojtan, C. (2019). Fundamental solutions for water wave animation. <i>ACM Transactions on Graphics</i>. ACM. <a href=\"https://doi.org/10.1145/3306346.3323002\">https://doi.org/10.1145/3306346.3323002</a>","ama":"Schreck C, Hafner C, Wojtan C. Fundamental solutions for water wave animation. <i>ACM Transactions on Graphics</i>. 2019;38(4). doi:<a href=\"https://doi.org/10.1145/3306346.3323002\">10.1145/3306346.3323002</a>"},"external_id":{"isi":["000475740600104"]},"ddc":["000","005"],"publication":"ACM Transactions on Graphics","type":"journal_article"},{"publisher":"Elsevier","date_updated":"2023-09-08T11:38:04Z","publication_status":"published","month":"05","date_published":"2019-05-31T00:00:00Z","article_processing_charge":"No","department":[{"_id":"SiHi"}],"oa":1,"oa_version":"Published Version","file":[{"date_updated":"2020-07-14T12:47:30Z","access_level":"open_access","file_size":8365970,"checksum":"a9ad2296726c9474ad5860c9c2f53622","content_type":"application/pdf","creator":"dernst","file_id":"6452","relation":"main_file","date_created":"2019-05-14T11:51:51Z","file_name":"2019_iScience_Amberg.pdf"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"publication_identifier":{"issn":["2589-0042"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","has_accepted_license":"1","status":"public","year":"2019","isi":1,"date_created":"2019-05-14T11:47:40Z","day":"31","abstract":[{"lang":"eng","text":"Epidermal growth factor receptor (EGFR) signaling controls skin development and homeostasis inmice and humans, and its deficiency causes severe skin inflammation, which might affect epidermalstem cell behavior. Here, we describe the inflammation-independent effects of EGFR deficiency dur-ing skin morphogenesis and in adult hair follicle stem cells. Expression and alternative splicing analysisof RNA sequencing data from interfollicular epidermis and outer root sheath indicate that EGFR con-trols genes involved in epidermal differentiation and also in centrosome function, DNA damage, cellcycle, and apoptosis. Genetic experiments employingp53deletion in EGFR-deficient epidermis revealthat EGFR signaling exhibitsp53-dependent functions in proliferative epidermal compartments, aswell asp53-independent functions in differentiated hair shaft keratinocytes. Loss of EGFR leads toabsence of LEF1 protein specifically in the innermost epithelial hair layers, resulting in disorganizationof medulla cells. Thus, our results uncover important spatial and temporal features of cell-autonomousEGFR functions in the epidermis."}],"language":[{"iso":"eng"}],"title":"EGFR controls hair shaft differentiation in a p53-independent manner","volume":15,"file_date_updated":"2020-07-14T12:47:30Z","ddc":["570"],"external_id":{"isi":["000470104600022"]},"citation":{"ama":"Amberg N, Sotiropoulou PA, Heller G, et al. EGFR controls hair shaft differentiation in a p53-independent manner. <i>iScience</i>. 2019;15:243-256. doi:<a href=\"https://doi.org/10.1016/j.isci.2019.04.018\">10.1016/j.isci.2019.04.018</a>","apa":"Amberg, N., Sotiropoulou, P. A., Heller, G., Lichtenberger, B. M., Holcmann, M., Camurdanoglu, B., … Sibilia, M. (2019). EGFR controls hair shaft differentiation in a p53-independent manner. <i>IScience</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.isci.2019.04.018\">https://doi.org/10.1016/j.isci.2019.04.018</a>","mla":"Amberg, Nicole, et al. “EGFR Controls Hair Shaft Differentiation in a P53-Independent Manner.” <i>IScience</i>, vol. 15, Elsevier, 2019, pp. 243–56, doi:<a href=\"https://doi.org/10.1016/j.isci.2019.04.018\">10.1016/j.isci.2019.04.018</a>.","ieee":"N. Amberg <i>et al.</i>, “EGFR controls hair shaft differentiation in a p53-independent manner,” <i>iScience</i>, vol. 15. Elsevier, pp. 243–256, 2019.","short":"N. Amberg, P.A. Sotiropoulou, G. Heller, B.M. Lichtenberger, M. Holcmann, B. Camurdanoglu, T. Baykuscheva-Gentscheva, C. Blanpain, M. Sibilia, IScience 15 (2019) 243–256.","chicago":"Amberg, Nicole, Panagiota A. Sotiropoulou, Gerwin Heller, Beate M. Lichtenberger, Martin Holcmann, Bahar Camurdanoglu, Temenuschka Baykuscheva-Gentscheva, Cedric Blanpain, and Maria Sibilia. “EGFR Controls Hair Shaft Differentiation in a P53-Independent Manner.” <i>IScience</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.isci.2019.04.018\">https://doi.org/10.1016/j.isci.2019.04.018</a>.","ista":"Amberg N, Sotiropoulou PA, Heller G, Lichtenberger BM, Holcmann M, Camurdanoglu B, Baykuscheva-Gentscheva T, Blanpain C, Sibilia M. 2019. EGFR controls hair shaft differentiation in a p53-independent manner. iScience. 15, 243–256."},"intvolume":"        15","publication":"iScience","type":"journal_article","_id":"6451","doi":"10.1016/j.isci.2019.04.018","quality_controlled":"1","author":[{"last_name":"Amberg","orcid":"0000-0002-3183-8207","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole","first_name":"Nicole"},{"last_name":"Sotiropoulou","full_name":"Sotiropoulou, Panagiota A.","first_name":"Panagiota A."},{"full_name":"Heller, Gerwin","first_name":"Gerwin","last_name":"Heller"},{"full_name":"Lichtenberger, Beate M.","first_name":"Beate M.","last_name":"Lichtenberger"},{"last_name":"Holcmann","full_name":"Holcmann, Martin","first_name":"Martin"},{"last_name":"Camurdanoglu","first_name":"Bahar","full_name":"Camurdanoglu, Bahar"},{"full_name":"Baykuscheva-Gentscheva, Temenuschka","first_name":"Temenuschka","last_name":"Baykuscheva-Gentscheva"},{"full_name":"Blanpain, Cedric","first_name":"Cedric","last_name":"Blanpain"},{"last_name":"Sibilia","full_name":"Sibilia, Maria","first_name":"Maria"}],"page":"243-256"},{"day":"03","abstract":[{"text":"Adult neural stem cells and multiciliated ependymalcells are glial cells essential for neurological func-tions. Together, they make up the adult neurogenicniche. Using both high-throughput clonal analysisand single-cell resolution of progenitor division pat-terns and fate, we show that these two componentsof the neurogenic niche are lineally related: adult neu-ral stem cells are sister cells to ependymal cells,whereas most ependymal cells arise from the termi-nal symmetric divisions of the lineage. Unexpectedly,we found that the antagonist regulators of DNA repli-cation, GemC1 and Geminin, can tune the proportionof neural stem cells and ependymal cells. Our find-ings reveal the controlled dynamic of the neurogenicniche ontogeny and identify the Geminin familymembers as key regulators of the initial pool of adultneural stem cells.","lang":"eng"}],"date_created":"2019-05-14T13:06:30Z","title":"Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members","language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:30Z","volume":102,"pmid":1,"scopus_import":"1","isi":1,"doi":"10.1016/j.neuron.2019.01.051","_id":"6454","project":[{"_id":"260018B0-B435-11E9-9278-68D0E5697425","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","call_identifier":"H2020","grant_number":"725780"}],"quality_controlled":"1","page":"159-172.e7","author":[{"first_name":"G","full_name":"Ortiz-Álvarez, G","last_name":"Ortiz-Álvarez"},{"last_name":"Daclin","first_name":"M","full_name":"Daclin, M"},{"last_name":"Shihavuddin","full_name":"Shihavuddin, A","first_name":"A"},{"last_name":"Lansade","first_name":"P","full_name":"Lansade, P"},{"last_name":"Fortoul","full_name":"Fortoul, A","first_name":"A"},{"last_name":"Faucourt","full_name":"Faucourt, M","first_name":"M"},{"first_name":"S","full_name":"Clavreul, S","last_name":"Clavreul"},{"last_name":"Lalioti","full_name":"Lalioti, ME","first_name":"ME"},{"full_name":"Taraviras, S","first_name":"S","last_name":"Taraviras"},{"first_name":"Simon","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer"},{"last_name":"Livet","full_name":"Livet, J","first_name":"J"},{"last_name":"Meunier","full_name":"Meunier, A","first_name":"A"},{"full_name":"Genovesio, A","first_name":"A","last_name":"Genovesio"},{"full_name":"Spassky, N","first_name":"N","last_name":"Spassky"}],"citation":{"ieee":"G. Ortiz-Álvarez <i>et al.</i>, “Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members,” <i>Neuron</i>, vol. 102, no. 1. Elsevier, p. 159–172.e7, 2019.","mla":"Ortiz-Álvarez, G., et al. “Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.” <i>Neuron</i>, vol. 102, no. 1, Elsevier, 2019, p. 159–172.e7, doi:<a href=\"https://doi.org/10.1016/j.neuron.2019.01.051\">10.1016/j.neuron.2019.01.051</a>.","apa":"Ortiz-Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt, M., … Spassky, N. (2019). Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members. <i>Neuron</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.neuron.2019.01.051\">https://doi.org/10.1016/j.neuron.2019.01.051</a>","ama":"Ortiz-Álvarez G, Daclin M, Shihavuddin A, et al. Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members. <i>Neuron</i>. 2019;102(1):159-172.e7. doi:<a href=\"https://doi.org/10.1016/j.neuron.2019.01.051\">10.1016/j.neuron.2019.01.051</a>","ista":"Ortiz-Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M, Clavreul S, Lalioti M, Taraviras S, Hippenmeyer S, Livet J, Meunier A, Genovesio A, Spassky N. 2019. Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members. Neuron. 102(1), 159–172.e7.","chicago":"Ortiz-Álvarez, G, M Daclin, A Shihavuddin, P Lansade, A Fortoul, M Faucourt, S Clavreul, et al. “Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.” <i>Neuron</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.neuron.2019.01.051\">https://doi.org/10.1016/j.neuron.2019.01.051</a>.","short":"G. Ortiz-Álvarez, M. Daclin, A. Shihavuddin, P. Lansade, A. Fortoul, M. Faucourt, S. Clavreul, M. Lalioti, S. Taraviras, S. Hippenmeyer, J. Livet, A. Meunier, A. Genovesio, N. Spassky, Neuron 102 (2019) 159–172.e7."},"ddc":["570"],"external_id":{"pmid":["30824354"],"isi":["000463337900018"]},"intvolume":"       102","type":"journal_article","publication":"Neuron","article_processing_charge":"No","department":[{"_id":"SiHi"}],"oa":1,"publisher":"Elsevier","ec_funded":1,"date_published":"2019-04-03T00:00:00Z","month":"04","date_updated":"2025-04-14T07:43:05Z","publication_status":"published","has_accepted_license":"1","year":"2019","status":"public","issue":"1","file":[{"date_created":"2019-05-15T09:28:41Z","file_name":"2019_Neuron_Ortiz.pdf","relation":"main_file","file_id":"6457","file_size":7288572,"content_type":"application/pdf","checksum":"1fb6e195c583eb0c5cabf26f69ff6675","access_level":"open_access","creator":"dernst","date_updated":"2020-07-14T12:47:30Z"}],"oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"publication_identifier":{"eissn":["1097-4199"],"issn":["0896-6273"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"publication":"Science","type":"journal_article","ddc":["570"],"external_id":{"isi":["000467631800034"],"pmid":["31073041"]},"citation":{"ama":"Telley L, Agirman G, Prados J, et al. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. <i>Science</i>. 2019;364(6440). doi:<a href=\"https://doi.org/10.1126/science.aav2522\">10.1126/science.aav2522</a>","apa":"Telley, L., Agirman, G., Prados, J., Amberg, N., Fièvre, S., Oberst, P., … Jabaudon, D. (2019). Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aav2522\">https://doi.org/10.1126/science.aav2522</a>","mla":"Telley, L., et al. “Temporal Patterning of Apical Progenitors and Their Daughter Neurons in the Developing Neocortex.” <i>Science</i>, vol. 364, no. 6440, eaav2522, AAAS, 2019, doi:<a href=\"https://doi.org/10.1126/science.aav2522\">10.1126/science.aav2522</a>.","ieee":"L. Telley <i>et al.</i>, “Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex,” <i>Science</i>, vol. 364, no. 6440. AAAS, 2019.","short":"L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fièvre, P. Oberst, G. Bartolini, I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon, Science 364 (2019).","chicago":"Telley, L, G Agirman, J Prados, Nicole Amberg, S Fièvre, P Oberst, G Bartolini, et al. “Temporal Patterning of Apical Progenitors and Their Daughter Neurons in the Developing Neocortex.” <i>Science</i>. AAAS, 2019. <a href=\"https://doi.org/10.1126/science.aav2522\">https://doi.org/10.1126/science.aav2522</a>.","ista":"Telley L, Agirman G, Prados J, Amberg N, Fièvre S, Oberst P, Bartolini G, Vitali I, Cadilhac C, Hippenmeyer S, Nguyen L, Dayer A, Jabaudon D. 2019. Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex. Science. 364(6440), eaav2522."},"intvolume":"       364","quality_controlled":"1","author":[{"full_name":"Telley, L","first_name":"L","last_name":"Telley"},{"full_name":"Agirman, G","first_name":"G","last_name":"Agirman"},{"last_name":"Prados","full_name":"Prados, J","first_name":"J"},{"full_name":"Amberg, Nicole","first_name":"Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3183-8207","last_name":"Amberg"},{"full_name":"Fièvre, S","first_name":"S","last_name":"Fièvre"},{"last_name":"Oberst","full_name":"Oberst, P","first_name":"P"},{"last_name":"Bartolini","full_name":"Bartolini, G","first_name":"G"},{"first_name":"I","full_name":"Vitali, I","last_name":"Vitali"},{"full_name":"Cadilhac, C","first_name":"C","last_name":"Cadilhac"},{"full_name":"Hippenmeyer, Simon","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer"},{"last_name":"Nguyen","full_name":"Nguyen, L","first_name":"L"},{"full_name":"Dayer, A","first_name":"A","last_name":"Dayer"},{"last_name":"Jabaudon","first_name":"D","full_name":"Jabaudon, D"}],"_id":"6455","doi":"10.1126/science.aav2522","project":[{"_id":"260018B0-B435-11E9-9278-68D0E5697425","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","call_identifier":"H2020"},{"name":"Role of Eed in neural stem cell lineage progression","call_identifier":"FWF","grant_number":"T01031","_id":"268F8446-B435-11E9-9278-68D0E5697425"}],"scopus_import":"1","isi":1,"pmid":1,"main_file_link":[{"open_access":"1","url":"https://orbi.uliege.be/bitstream/2268/239604/1/Telley_Agirman_Science2019.pdf"}],"related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/how-to-generate-a-brain-of-correct-size-and-composition/"}]},"language":[{"iso":"eng"}],"title":"Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex","volume":364,"date_created":"2019-05-14T13:07:47Z","abstract":[{"lang":"eng","text":"During corticogenesis, distinct subtypes of neurons are sequentially born from ventricular zone progenitors. How these cells are molecularly temporally patterned is poorly understood. We used single-cell RNA sequencing at high temporal resolution to trace the lineage of the molecular identities of successive generations of apical progenitors (APs) and their daughter neurons in mouse embryos. We identified a core set of evolutionarily conserved, temporally patterned genes that drive APs from internally driven to more exteroceptive states. We found that the Polycomb repressor complex 2 (PRC2) epigenetically regulates AP temporal progression. Embryonic age–dependent AP molecular states are transmitted to their progeny as successive ground states, onto which essentially conserved early postmitotic differentiation programs are applied, and are complemented by later-occurring environment-dependent signals. Thus, epigenetically regulated temporal molecular birthmarks present in progenitors act in their postmitotic progeny to seed adult neuronal diversity."}],"day":"10","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa_version":"Published Version","year":"2019","status":"public","issue":"6440","publication_status":"published","date_updated":"2026-06-18T19:04:26Z","article_type":"original","date_published":"2019-05-10T00:00:00Z","month":"05","publisher":"AAAS","ec_funded":1,"oa":1,"article_processing_charge":"No","article_number":"eaav2522","department":[{"_id":"SiHi"}]},{"oa":1,"department":[{"_id":"ToHe"},{"_id":"KrCh"}],"conference":{"start_date":"2019-07-13","name":"CAV: Computer Aided Verification","end_date":"2019-07-18","location":"New York, NY, United States"},"article_processing_charge":"No","date_published":"2019-07-12T00:00:00Z","month":"07","publication_status":"published","date_updated":"2025-04-15T06:26:05Z","publisher":"Springer","status":"public","year":"2019","has_accepted_license":"1","corr_author":"1","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_identifier":{"isbn":["9783030255398"],"issn":["0302-9743"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png"},"alternative_title":["LNCS"],"file":[{"date_updated":"2020-07-14T12:47:31Z","creator":"dernst","content_type":"application/pdf","checksum":"c231579f2485c6fd4df17c9443a4d80b","file_size":659766,"access_level":"open_access","file_id":"6816","relation":"main_file","file_name":"2019_CAV_Avni.pdf","date_created":"2019-08-14T09:35:24Z"}],"oa_version":"Published Version","file_date_updated":"2020-07-14T12:47:31Z","volume":11561,"title":"Run-time optimization for learned controllers through quantitative games","language":[{"iso":"eng"}],"day":"12","abstract":[{"lang":"eng","text":"A controller is a device that interacts with a plant. At each time point,it reads the plant’s state and issues commands with the goal that the plant oper-ates optimally. Constructing optimal controllers is a fundamental and challengingproblem. Machine learning techniques have recently been successfully applied totrain controllers, yet they have limitations. Learned controllers are monolithic andhard to reason about. In particular, it is difficult to add features without retraining,to guarantee any level of performance, and to achieve acceptable performancewhen encountering untrained scenarios. These limitations can be addressed bydeploying quantitative run-timeshieldsthat serve as a proxy for the controller.At each time point, the shield reads the command issued by the controller andmay choose to alter it before passing it on to the plant. We show how optimalshields that interfere as little as possible while guaranteeing a desired level ofcontroller performance, can be generated systematically and automatically usingreactive  synthesis.  First,  we  abstract  the  plant  by  building  a  stochastic  model.Second, we consider the learned controller to be a black box. Third, we mea-surecontroller performanceandshield interferenceby two quantitative run-timemeasures that are formally defined using weighted automata. Then, the problemof constructing a shield that guarantees maximal performance with minimal inter-ference is the problem of finding an optimal strategy in a stochastic2-player game“controller versus shield” played on the abstract state space of the plant with aquantitative objective obtained from combining the performance and interferencemeasures. We illustrate the effectiveness of our approach by automatically con-structing lightweight shields for learned traffic-light controllers in various roadnetworks. The shields we generate avoid liveness bugs, improve controller per-formance in untrained and changing traffic situations, and add features to learnedcontrollers, such as giving priority to emergency vehicles."}],"date_created":"2019-05-16T11:22:30Z","isi":1,"scopus_import":"1","author":[{"id":"463C8BC2-F248-11E8-B48F-1D18A9856A87","full_name":"Avni, Guy","first_name":"Guy","last_name":"Avni","orcid":"0000-0001-5588-8287"},{"last_name":"Bloem","first_name":"Roderick","full_name":"Bloem, Roderick"},{"orcid":"0000-0002-4561-241X","last_name":"Chatterjee","first_name":"Krishnendu","full_name":"Chatterjee, Krishnendu","id":"2E5DCA20-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000−0002−2985−7724","last_name":"Henzinger","first_name":"Thomas A","full_name":"Henzinger, Thomas A","id":"40876CD8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Konighofer","first_name":"Bettina","full_name":"Konighofer, Bettina"},{"last_name":"Pranger","full_name":"Pranger, Stefan","first_name":"Stefan"}],"page":"630-649","quality_controlled":"1","project":[{"_id":"264B3912-B435-11E9-9278-68D0E5697425","name":"Formal Methods meets Algorithmic Game Theory","grant_number":"M02369","call_identifier":"FWF"},{"_id":"25F42A32-B435-11E9-9278-68D0E5697425","grant_number":"Z211","call_identifier":"FWF","name":"Formal methods for the design and analysis of complex systems"},{"_id":"25832EC2-B435-11E9-9278-68D0E5697425","name":"Rigorous Systems Engineering","call_identifier":"FWF","grant_number":"S 11407_N23"}],"doi":"10.1007/978-3-030-25540-4_36","_id":"6462","type":"conference","publication":"31st International Conference on Computer-Aided Verification","intvolume":"     11561","citation":{"short":"G. Avni, R. Bloem, K. Chatterjee, T.A. Henzinger, B. Konighofer, S. Pranger, in:, 31st International Conference on Computer-Aided Verification, Springer, 2019, pp. 630–649.","chicago":"Avni, Guy, Roderick Bloem, Krishnendu Chatterjee, Thomas A Henzinger, Bettina Konighofer, and Stefan Pranger. “Run-Time Optimization for Learned Controllers through Quantitative Games.” In <i>31st International Conference on Computer-Aided Verification</i>, 11561:630–49. Springer, 2019. <a href=\"https://doi.org/10.1007/978-3-030-25540-4_36\">https://doi.org/10.1007/978-3-030-25540-4_36</a>.","ista":"Avni G, Bloem R, Chatterjee K, Henzinger TA, Konighofer B, Pranger S. 2019. Run-time optimization for learned controllers through quantitative games. 31st International Conference on Computer-Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 11561, 630–649.","ama":"Avni G, Bloem R, Chatterjee K, Henzinger TA, Konighofer B, Pranger S. Run-time optimization for learned controllers through quantitative games. In: <i>31st International Conference on Computer-Aided Verification</i>. Vol 11561. Springer; 2019:630-649. doi:<a href=\"https://doi.org/10.1007/978-3-030-25540-4_36\">10.1007/978-3-030-25540-4_36</a>","apa":"Avni, G., Bloem, R., Chatterjee, K., Henzinger, T. A., Konighofer, B., &#38; Pranger, S. (2019). Run-time optimization for learned controllers through quantitative games. In <i>31st International Conference on Computer-Aided Verification</i> (Vol. 11561, pp. 630–649). New York, NY, United States: Springer. <a href=\"https://doi.org/10.1007/978-3-030-25540-4_36\">https://doi.org/10.1007/978-3-030-25540-4_36</a>","mla":"Avni, Guy, et al. “Run-Time Optimization for Learned Controllers through Quantitative Games.” <i>31st International Conference on Computer-Aided Verification</i>, vol. 11561, Springer, 2019, pp. 630–49, doi:<a href=\"https://doi.org/10.1007/978-3-030-25540-4_36\">10.1007/978-3-030-25540-4_36</a>.","ieee":"G. Avni, R. Bloem, K. Chatterjee, T. A. Henzinger, B. Konighofer, and S. Pranger, “Run-time optimization for learned controllers through quantitative games,” in <i>31st International Conference on Computer-Aided Verification</i>, New York, NY, United States, 2019, vol. 11561, pp. 630–649."},"external_id":{"isi":["000491468000036"]},"ddc":["000"]}]