[{"fulldoi":"https://doi.org/10.1016/j.rbmo.2025.104942","isi":1,"date_published":"2025-07-17T00:00:00Z","oa_version":"None","publication_status":"published","author":[{"first_name":"Iveta","last_name":"Yotova","full_name":"Yotova, Iveta"},{"first_name":"Katharina","last_name":"Proestling","full_name":"Proestling, Katharina"},{"last_name":"Pauler","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","full_name":"Pauler, Florian","first_name":"Florian","orcid":"0000-0002-7462-0048"},{"first_name":"Lisa","full_name":"Rainer, Lisa","last_name":"Rainer"},{"full_name":"Kaup, Leonie","last_name":"Kaup","first_name":"Leonie"},{"full_name":"Heine, Jana","last_name":"Heine","first_name":"Jana"},{"first_name":"Lejla","last_name":"Sandrieser","full_name":"Sandrieser, Lejla"},{"first_name":"René","last_name":"Wenzl","full_name":"Wenzl, René"},{"last_name":"Hudson","full_name":"Hudson, Quanah J.","first_name":"Quanah J."}],"issue":"3","intvolume":"        51","abstract":[{"lang":"eng","text":"Research question: Is LINC01638 involved in regulation of epithelial-to-mesenchymal transition (EMT) in endometriosis?\r\nDesign: A prospective patient cohort study was combined with functional experiments in the 12Z endometriosis epithelial cell line to investigate the role of LINC01638 in endometriosis. Eutopic endometrial samples were collected by curettage, and ectopic endometrial lesion samples were collected by laparoscopic surgery from 24 control patients and 41 patients with endometriosis. The phenotype of 12Z cells was assessed following LINC01638 knockdown using siRNA, performing proliferation, adhesion, migration and invasion assays, as well as assessing apoptosis and cell cycle changes with flow cytometry assays. In order to assess the relationship between LINC01638 and histone deacetylase class 1 enzyme (HDAC1), LINC01638 knockdown was combined with HDAC inhibition with the specific HDAC inhibitor romidepsin.\r\nResults: LINC01638 was up-regulated in the epithelial layer of endometriotic lesions, and LINC01638 knockdown in 12Z cells led to reduced proliferation, adhesion, migration and invasion. The reduction in proliferation was associated with increased p21 and p27 expression, and G1 phase arrest. Further analysis of LINC01638 control and knockdown cells revealed that a number of transcription factors associated with EMT are down-regulated in knockdown cells, along with the cytoskeleton regulatory gene RHOB, while HDAC1 was up-regulated. Chromatin immunoprecipitation analysis and HDAC1 inhibitory treatment combined with LINC01638 knockdown indicated that LINC01638 regulates RHOB expression via HDAC1-mediated promoter deacetylation. RHOB is up-regulated in the epithelial layer of endometriotic lesions compared with eutopic endometrium, supporting a role in the disease.\r\nConclusions: LINC01638 is an epigenetic regulator of the pathogenesis of endometriosis, promoting proliferation and EMT of endometriotic lesions."}],"quality_controlled":"1","doi":"10.1016/j.rbmo.2025.104942","year":"2025","_id":"20079","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","OA_type":"closed access","citation":{"ama":"Yotova I, Proestling K, Pauler F, et al. LINC01638 promotes epithelial-to-mesenchymal transition in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression. <i>Reproductive Biomedicine Online</i>. 2025;51(3). doi:<a href=\"https://doi.org/10.1016/j.rbmo.2025.104942\">10.1016/j.rbmo.2025.104942</a>","ista":"Yotova I, Proestling K, Pauler F, Rainer L, Kaup L, Heine J, Sandrieser L, Wenzl R, Hudson QJ. 2025. LINC01638 promotes epithelial-to-mesenchymal transition in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression. Reproductive Biomedicine Online. 51(3), 104942.","ieee":"I. Yotova <i>et al.</i>, “LINC01638 promotes epithelial-to-mesenchymal transition in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression,” <i>Reproductive Biomedicine Online</i>, vol. 51, no. 3. Elsevier, 2025.","apa":"Yotova, I., Proestling, K., Pauler, F., Rainer, L., Kaup, L., Heine, J., … Hudson, Q. J. (2025). LINC01638 promotes epithelial-to-mesenchymal transition in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression. <i>Reproductive Biomedicine Online</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.rbmo.2025.104942\">https://doi.org/10.1016/j.rbmo.2025.104942</a>","short":"I. Yotova, K. Proestling, F. Pauler, L. Rainer, L. Kaup, J. Heine, L. Sandrieser, R. Wenzl, Q.J. Hudson, Reproductive Biomedicine Online 51 (2025).","mla":"Yotova, Iveta, et al. “LINC01638 Promotes Epithelial-to-Mesenchymal Transition in Endometriosis Epithelial Cells by up-Regulating RHOB via HDAC1 Suppression.” <i>Reproductive Biomedicine Online</i>, vol. 51, no. 3, 104942, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.rbmo.2025.104942\">10.1016/j.rbmo.2025.104942</a>.","chicago":"Yotova, Iveta, Katharina Proestling, Florian Pauler, Lisa Rainer, Leonie Kaup, Jana Heine, Lejla Sandrieser, René Wenzl, and Quanah J. Hudson. “LINC01638 Promotes Epithelial-to-Mesenchymal Transition in Endometriosis Epithelial Cells by up-Regulating RHOB via HDAC1 Suppression.” <i>Reproductive Biomedicine Online</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.rbmo.2025.104942\">https://doi.org/10.1016/j.rbmo.2025.104942</a>."},"article_processing_charge":"No","external_id":{"pmid":["40680553"],"isi":["001549819000002"]},"publication":"Reproductive Biomedicine Online","article_number":"104942","type":"journal_article","month":"07","date_created":"2025-07-27T22:01:25Z","pmid":1,"acknowledgement":"The authors wish to thank all the participants and health professionals involved in this study. In addition, the authors wish to thank technical assistants Barbara Widmar, Matthias Witzmann-Stern and Isabella Haslinger for their work assisting with this study; and Simon Hippenmeyer for access to bioinformatic infrastructure and resources.\r\nOpen access funding was provided by the Medical University of Vienna.","article_type":"original","volume":51,"department":[{"_id":"SiHi"}],"language":[{"iso":"eng"}],"scopus_import":"1","publisher":"Elsevier","publication_identifier":{"eissn":["1472-6491"],"issn":["1472-6483"]},"date_updated":"2025-09-30T14:10:46Z","title":"LINC01638 promotes epithelial-to-mesenchymal transition in endometriosis epithelial cells by up-regulating RHOB via HDAC1 suppression","day":"17"},{"publisher":"Frontiers Media","ec_funded":1,"publication_identifier":{"eissn":["1664-462X"]},"corr_author":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"E-Lib"}],"OA_place":"publisher","file_date_updated":"2025-07-31T07:28:54Z","scopus_import":"1","has_accepted_license":"1","department":[{"_id":"EdHa"},{"_id":"EvBe"},{"_id":"CaGu"}],"language":[{"iso":"eng"}],"file":[{"date_created":"2025-07-31T07:28:54Z","access_level":"open_access","date_updated":"2025-07-31T07:28:54Z","success":1,"creator":"dernst","file_name":"2025_FrontiersPlantSc_Gallemi.pdf","relation":"main_file","content_type":"application/pdf","checksum":"9e6b8b53ba56d4a24a9bd91cf6d2dc58","file_size":3665187,"file_id":"20093"}],"type":"journal_article","month":"07","ddc":["580"],"pmid":1,"date_created":"2025-07-27T22:01:26Z","acknowledgement":"The author(s) declare that financial support was received for the research and/or publication of this article. This work was supported by grants from the European Research Council (Starting Independent Research Grant ERC-2007-Stg- 207362-HCPO to EB) and MG was recipient of an IST Interdisciplinary project (IC1022IPC03).\r\nWe acknowledge Jaume F. Martı́nez Garcı́a for phyAphyB mutant seeds. We acknowledge CF Nanobiotechnology of CIISB, Instruct-CZ Centre, supported by MEYS CR (LM2018127). We gratefully acknowledge support by the Scientific Service Units at ISTA, including the Imaging and Optics and Lab Support facilities and Library. We thank Stefan Riegler for the efforts to establish immunodetection method.","volume":16,"article_type":"original","day":"04","oa":1,"title":"Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties","DOAJ_listed":"1","APC_amount":"3642,79 EUR","date_updated":"2026-05-20T07:53:03Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"quality_controlled":"1","doi":"10.3389/fpls.2025.1612366","publication_status":"published","author":[{"id":"460C6802-F248-11E8-B48F-1D18A9856A87","full_name":"Gallemi, Marçal","last_name":"Gallemi","orcid":"0000-0003-4675-6893","first_name":"Marçal"},{"first_name":"Juan C","orcid":"0000-0001-9179-6099","last_name":"Montesinos López","id":"310A8E3E-F248-11E8-B48F-1D18A9856A87","full_name":"Montesinos López, Juan C"},{"last_name":"Zarevski","id":"18e95355-e05a-11ea-a9c0-8fba1b89e83a","full_name":"Zarevski, Nikola","first_name":"Nikola"},{"first_name":"Jan","last_name":"Pribyl","full_name":"Pribyl, Jan"},{"first_name":"Petr","full_name":"Skládal, Petr","last_name":"Skládal"},{"orcid":"0000-0001-6005-1561","first_name":"Edouard B","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","last_name":"Hannezo"},{"first_name":"Eva","orcid":"0000-0002-8510-9739","last_name":"Benková","full_name":"Benková, Eva","id":"38F4F166-F248-11E8-B48F-1D18A9856A87"}],"abstract":[{"text":"Introduction: Acid-growth theory has been postulated in the 70s to explain the rapid elongation of plant cells in response to the hormone auxin. More recently, it has been demonstrated that activation of the proton ATPs pump (H+-ATPs) promoting acidification of the apoplast is the principal mechanism by which auxin and other hormones such as brassinosteroids (BR) induce cell elongation. Despite these advances, the impact of this acidification on the mechanical properties of the cell wall remained largely unexplored.\r\n\r\nMethods: Here, we use elongation assays of Arabidopsis thaliana hypocotyls and Atomic Force Microscopy (AFM) to correlate hormone-induced tissue elongation and local changes in cell wall mechanical properties. Furthermore, employing transgenic lines over-expressing Pectin Methyl Esterase (PME), along with calcium chelators, we investigate the effect of pectin modification in hormone-driven cell elongation.\r\n\r\nResults: We demonstrate that acidification of apoplast is necessary and sufficient to induce cell elongation through promoting cell wall softening. Moreover, we show that enhanced PME activity can induce both cell wall softening or stiffening in extracellular calcium dependent-manner and that tight control of PME activity is required for proper hypocotyl elongation.\r\n\r\nDiscussion: Our results confirm a dual role of PME in plant cell elongation. However, further investigation is needed to assess the status of pectin following short- or long-term PME treatments in order to determine if pectin methyl-esterification might promote its degradation as well as the role of PME inhibitors upon PME induction.","lang":"eng"}],"intvolume":"        16","oa_version":"Published Version","fulldoi":"https://doi.org/10.3389/fpls.2025.1612366","project":[{"_id":"253FCA6A-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Hormonal cross-talk in plant organogenesis","grant_number":"207362"},{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"isi":1,"date_published":"2025-07-04T00:00:00Z","publication":"Frontiers in Plant Science","article_number":"1612366","citation":{"ama":"Gallemi M, Montesinos López JC, Zarevski N, et al. Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties. <i>Frontiers in Plant Science</i>. 2025;16. doi:<a href=\"https://doi.org/10.3389/fpls.2025.1612366\">10.3389/fpls.2025.1612366</a>","ista":"Gallemi M, Montesinos López JC, Zarevski N, Pribyl J, Skládal P, Hannezo EB, Benková E. 2025. Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties. Frontiers in Plant Science. 16, 1612366.","ieee":"M. Gallemi <i>et al.</i>, “Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties,” <i>Frontiers in Plant Science</i>, vol. 16. Frontiers Media, 2025.","apa":"Gallemi, M., Montesinos López, J. C., Zarevski, N., Pribyl, J., Skládal, P., Hannezo, E. B., &#38; Benková, E. (2025). Dual role of pectin methyl esterase activity in the regulation of plant cell wall biophysical properties. <i>Frontiers in Plant Science</i>. Frontiers Media. <a href=\"https://doi.org/10.3389/fpls.2025.1612366\">https://doi.org/10.3389/fpls.2025.1612366</a>","short":"M. Gallemi, J.C. Montesinos López, N. Zarevski, J. Pribyl, P. Skládal, E.B. Hannezo, E. Benková, Frontiers in Plant Science 16 (2025).","chicago":"Gallemi, Marçal, Juan C Montesinos López, Nikola Zarevski, Jan Pribyl, Petr Skládal, Edouard B Hannezo, and Eva Benková. “Dual Role of Pectin Methyl Esterase Activity in the Regulation of Plant Cell Wall Biophysical Properties.” <i>Frontiers in Plant Science</i>. Frontiers Media, 2025. <a href=\"https://doi.org/10.3389/fpls.2025.1612366\">https://doi.org/10.3389/fpls.2025.1612366</a>.","mla":"Gallemi, Marçal, et al. “Dual Role of Pectin Methyl Esterase Activity in the Regulation of Plant Cell Wall Biophysical Properties.” <i>Frontiers in Plant Science</i>, vol. 16, 1612366, Frontiers Media, 2025, doi:<a href=\"https://doi.org/10.3389/fpls.2025.1612366\">10.3389/fpls.2025.1612366</a>."},"article_processing_charge":"Yes","PlanS_conform":"1","external_id":{"isi":["001530690900001"],"pmid":["40688689"]},"_id":"20080","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","OA_type":"gold","year":"2025"},{"corr_author":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"scopus_import":"1","OA_place":"publisher","file_date_updated":"2025-07-31T08:00:33Z","has_accepted_license":"1","publisher":"Springer Nature","publication_identifier":{"eissn":["1529-2916"],"issn":["1529-2908"]},"type":"journal_article","month":"08","ddc":["570"],"pmid":1,"page":"1258–1266","date_created":"2025-07-27T22:01:26Z","article_type":"letter_note","volume":26,"acknowledgement":"This research was supported by the Scientific Service Units of ISTA through resources provided by the Imaging and Optics, Preclinical and Lab Support Facilities. In particular, we thank M. A. Symth and F. G. G. Leite, from the Virus Service Team, who helped generating the lentiviral particles used in this study. We thank all the members of the Sixt group for valuable discussions and feedback, in particular, I. Mayer, for helping with T cell isolation and Z. (P.) Li for providing the Actin–GFP DC line. We are also thankful to J. Mandl and C. Shen for their feedback during the writing of this manuscript. This work was supported by a European Research Council grant ERC-SyG 101071793 to M.S. M.J.A. was supported by an HFSP Postdoctoral Fellowship LTF 177 2021 and A.J.G. by a Lise Meitner Fellowship of the FWF (Austrian Science Fund). Y.F. was supported by the AMED-CREST (JP19gm1310005), the Medical Research Center Initiative for High Depth Omics and CURE:JPMXP1323015486 for MIB, Kyushu University. Open access funding provided by Institute of Science and Technology (IST Austria).","department":[{"_id":"MiSi"},{"_id":"NanoFab"},{"_id":"Bio"}],"language":[{"iso":"eng"}],"file":[{"file_name":"2025_NatureImmunology_ReisRodrigues.pdf","creator":"dernst","date_updated":"2025-07-31T08:00:33Z","success":1,"date_created":"2025-07-31T08:00:33Z","access_level":"open_access","file_id":"20096","file_size":13514646,"checksum":"0c725123dca7797c682609bff2c4c5ac","content_type":"application/pdf","relation":"main_file"}],"oa":1,"day":"01","related_material":{"record":[{"status":"public","id":"20149","relation":"dissertation_contains"}],"link":[{"description":"News on ISTA website","url":"https://ista.ac.at/en/news/bench-pressing-cells/","relation":"press_release"}]},"date_updated":"2026-04-28T13:26:50Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"Migrating immune cells globally coordinate protrusive forces","quality_controlled":"1","doi":"10.1038/s41590-025-02211-w","date_published":"2025-08-01T00:00:00Z","fulldoi":"https://doi.org/10.1038/s41590-025-02211-w","project":[{"_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","grant_number":"101071793","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces"},{"_id":"c092d618-5a5b-11eb-8a69-f92e1e843fc8","grant_number":"944-2020","name":"Bioelectric patrolling: the role of the local membrane potential in immune cell migration"}],"isi":1,"oa_version":"Published Version","author":[{"orcid":"0000-0003-1681-508X","first_name":"Patricia","id":"26E95904-5160-11E9-9C0B-C5B0DC97E90F","full_name":"Dos Reis Rodrigues, Patricia","last_name":"Dos Reis Rodrigues"},{"first_name":"Mario","orcid":"0000-0001-6406-524X","last_name":"Avellaneda Sarrió","id":"DC4BA84C-56E6-11EA-AD5D-348C3DDC885E","full_name":"Avellaneda Sarrió, Mario"},{"full_name":"Canigova, Nikola","id":"3795523E-F248-11E8-B48F-1D18A9856A87","last_name":"Canigova","orcid":"0000-0002-8518-5926","first_name":"Nikola"},{"id":"397A88EE-F248-11E8-B48F-1D18A9856A87","full_name":"Gärtner, Florian R","last_name":"Gärtner","orcid":"0000-0001-6120-3723","first_name":"Florian R"},{"last_name":"Vaahtomeri","id":"368EE576-F248-11E8-B48F-1D18A9856A87","full_name":"Vaahtomeri, Kari","first_name":"Kari","orcid":"0000-0001-7829-3518"},{"orcid":"0000-0003-4844-6311","first_name":"Michael","id":"3BE60946-F248-11E8-B48F-1D18A9856A87","full_name":"Riedl, Michael","last_name":"Riedl"},{"id":"4C7D837E-F248-11E8-B48F-1D18A9856A87","full_name":"De Vries, Ingrid","last_name":"De Vries","first_name":"Ingrid"},{"first_name":"Jack","orcid":"0000-0001-5145-4609","last_name":"Merrin","id":"4515C308-F248-11E8-B48F-1D18A9856A87","full_name":"Merrin, Jack"},{"last_name":"Hauschild","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert","first_name":"Robert","orcid":"0000-0001-9843-3522"},{"first_name":"Yoshinori","last_name":"Fukui","full_name":"Fukui, Yoshinori"},{"full_name":"Juanes Garcia, Alba","id":"40F05888-F248-11E8-B48F-1D18A9856A87","last_name":"Juanes Garcia","orcid":"0000-0002-1009-9652","first_name":"Alba"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt"}],"publication_status":"published","abstract":[{"lang":"eng","text":"Efficient immune responses rely on the capacity of leukocytes to traverse diverse and complex tissues. To meet such changing environmental conditions, leukocytes usually adopt an ameboid configuration, using their forward-positioned nucleus as a probe to identify and follow the path of least resistance among pre-existing pores. We show that, in dense environments where even the largest pores preclude free passage, leukocytes position their nucleus behind the centrosome and organelles. The local compression imposed on the cell body by its surroundings triggers assembly of a central F-actin pool, located between cell front and nucleus. Central actin pushes outward to transiently dilate a path for organelles and nucleus. Pools of central and front actin are tightly coupled and experimental depletion of the central pool enhances actin accumulation and protrusion formation at the cell front. Although this shifted balance speeds up cells in permissive environments, migration in restrictive environments is impaired, as the unleashed leading edge dissociates from the trapped cell body. Our findings establish an actin regulatory loop that balances path dilation with advancement of the leading edge to maintain cellular coherence."}],"intvolume":"        26","citation":{"ista":"Dos Reis Rodrigues P, Avellaneda Sarrió M, Canigova N, Gärtner FR, Vaahtomeri K, Riedl M, de Vries I, Merrin J, Hauschild R, Fukui Y, Juanes Garcia A, Sixt MK. 2025. Migrating immune cells globally coordinate protrusive forces. Nature Immunology. 26, 1258–1266.","apa":"Dos Reis Rodrigues, P., Avellaneda Sarrió, M., Canigova, N., Gärtner, F. R., Vaahtomeri, K., Riedl, M., … Sixt, M. K. (2025). Migrating immune cells globally coordinate protrusive forces. <i>Nature Immunology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41590-025-02211-w\">https://doi.org/10.1038/s41590-025-02211-w</a>","ieee":"P. Dos Reis Rodrigues <i>et al.</i>, “Migrating immune cells globally coordinate protrusive forces,” <i>Nature Immunology</i>, vol. 26. Springer Nature, pp. 1258–1266, 2025.","short":"P. Dos Reis Rodrigues, M. Avellaneda Sarrió, N. Canigova, F.R. Gärtner, K. Vaahtomeri, M. Riedl, I. de Vries, J. Merrin, R. Hauschild, Y. Fukui, A. Juanes Garcia, M.K. Sixt, Nature Immunology 26 (2025) 1258–1266.","mla":"Dos Reis Rodrigues, Patricia, et al. “Migrating Immune Cells Globally Coordinate Protrusive Forces.” <i>Nature Immunology</i>, vol. 26, Springer Nature, 2025, pp. 1258–1266, doi:<a href=\"https://doi.org/10.1038/s41590-025-02211-w\">10.1038/s41590-025-02211-w</a>.","chicago":"Dos Reis Rodrigues, Patricia, Mario Avellaneda Sarrió, Nikola Canigova, Florian R Gärtner, Kari Vaahtomeri, Michael Riedl, Ingrid de Vries, et al. “Migrating Immune Cells Globally Coordinate Protrusive Forces.” <i>Nature Immunology</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41590-025-02211-w\">https://doi.org/10.1038/s41590-025-02211-w</a>.","ama":"Dos Reis Rodrigues P, Avellaneda Sarrió M, Canigova N, et al. Migrating immune cells globally coordinate protrusive forces. <i>Nature Immunology</i>. 2025;26:1258–1266. doi:<a href=\"https://doi.org/10.1038/s41590-025-02211-w\">10.1038/s41590-025-02211-w</a>"},"article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","external_id":{"pmid":["40664976"],"isi":["001529134300001"]},"publication":"Nature Immunology","year":"2025","_id":"20082","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","status":"public","OA_type":"hybrid"},{"status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20098","OA_type":"gold","year":"2025","publication":"Environmental Research: Climate","article_number":"035005","citation":{"short":"Y.-L. Hwong, E. Byers, M. Werning, Y. Quilcaille, Environmental Research: Climate 4 (2025).","chicago":"Hwong, Yi-Ling, Edward Byers, Michaela Werning, and Yann Quilcaille. “Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages.” <i>Environmental Research: Climate</i>. IOP Publishing, 2025. <a href=\"https://doi.org/10.1088/2752-5295/adec11\">https://doi.org/10.1088/2752-5295/adec11</a>.","mla":"Hwong, Yi-Ling, et al. “Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages.” <i>Environmental Research: Climate</i>, vol. 4, no. 3, 035005, IOP Publishing, 2025, doi:<a href=\"https://doi.org/10.1088/2752-5295/adec11\">10.1088/2752-5295/adec11</a>.","ieee":"Y.-L. Hwong, E. Byers, M. Werning, and Y. Quilcaille, “Sustainable development key to limiting climate change-driven wildfire damages,” <i>Environmental Research: Climate</i>, vol. 4, no. 3. IOP Publishing, 2025.","ista":"Hwong Y-L, Byers E, Werning M, Quilcaille Y. 2025. Sustainable development key to limiting climate change-driven wildfire damages. Environmental Research: Climate. 4(3), 035005.","apa":"Hwong, Y.-L., Byers, E., Werning, M., &#38; Quilcaille, Y. (2025). Sustainable development key to limiting climate change-driven wildfire damages. <i>Environmental Research: Climate</i>. IOP Publishing. <a href=\"https://doi.org/10.1088/2752-5295/adec11\">https://doi.org/10.1088/2752-5295/adec11</a>","ama":"Hwong Y-L, Byers E, Werning M, Quilcaille Y. Sustainable development key to limiting climate change-driven wildfire damages. <i>Environmental Research: Climate</i>. 2025;4(3). doi:<a href=\"https://doi.org/10.1088/2752-5295/adec11\">10.1088/2752-5295/adec11</a>"},"article_processing_charge":"Yes","PlanS_conform":"1","author":[{"first_name":"Yi-Ling","orcid":"0000-0001-9281-3479","last_name":"Hwong","full_name":"Hwong, Yi-Ling","id":"1217aa61-4dd1-11ec-9ac3-f2ba3f17ee22"},{"last_name":"Byers","full_name":"Byers, Edward","first_name":"Edward"},{"first_name":"Michaela","last_name":"Werning","full_name":"Werning, Michaela"},{"first_name":"Yann","full_name":"Quilcaille, Yann","last_name":"Quilcaille"}],"publication_status":"published","issue":"3","abstract":[{"text":"Climate change is causing wildfires to become more frequent and intense. While predicting burned areas using bioclimatic and anthropogenic factors is an active research area, few studies have examined what drives the economic damages of wildfires. Our study aims to fill this gap by analyzing key factors influencing global economic wildfire damages and projecting future damages under three shared socioeconomic pathways (SSPs). We apply regression analyses to identify significant predictors of economic wildfire damages at country levels and use the fitted model to project future damages under SSP126, SSP245, and SSP370. Results show that the human vulnerability index (HVI), reflecting socioeconomic conditions, is the strongest predictor of historical wildfire damages, followed by water vapor pressure deficit during the fire season and population density around forested areas. We found high population density to be associated with lower damages. These findings contrast with studies of burned areas, where climate factors are more dominant. Our model projects that by 2070, average global economic wildfire damages will be three times higher under SSP370 than SSP126. Our model also shows that following SSP126 not only reduces wildfire damages but also lessens the inequalities in damage distribution across countries. This pathway’s dual focus on equitable socioeconomic progress and climate action potentially enhances a country’s resilience that helps mitigate wildfire damages. Our analyses also indicate that strong socioeconomic development can offset wildfire damages associated with climate hazards, although this is less certain under SSP370. SSP126’s integrated approach improves both socioeconomic conditions and limits global warming, providing substantial benefits to less developed countries while still reducing damages in developed nations, despite their already low HVI scores. Our work complements existing research on burned areas and underscores the importance of sustainable development and international collaboration in reducing the economic damages of wildfires.","lang":"eng"}],"intvolume":"         4","oa_version":"Published Version","fulldoi":"https://doi.org/10.1088/2752-5295/adec11","date_published":"2025-07-15T00:00:00Z","project":[{"name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"}],"doi":"10.1088/2752-5295/adec11","quality_controlled":"1","DOAJ_listed":"1","title":"Sustainable development key to limiting climate change-driven wildfire damages","date_updated":"2025-08-04T07:46:33Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"15","related_material":{"record":[{"id":"20107","relation":"research_data","status":"public"}]},"oa":1,"language":[{"iso":"eng"}],"department":[{"_id":"CaMu"}],"file":[{"creator":"dernst","file_name":"2025_EnvironResearchClimate_Hwong.pdf","date_created":"2025-08-04T07:38:14Z","access_level":"open_access","success":1,"date_updated":"2025-08-04T07:38:14Z","checksum":"ca679496767021e792b0378c48fdee8c","file_size":2807041,"file_id":"20108","relation":"main_file","content_type":"application/pdf"}],"ddc":["550"],"type":"journal_article","month":"07","article_type":"original","acknowledgement":"We thank Marina Andrijevic, Giacomo Falchetta, Samuel Lüthi, Caroline Muller, Carl Schleussner, and Adriano Vinca for providing useful ideas and feedback for this work. YLH is supported by funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie Grant No. 101034413. EB, MW, and YQ are supported by the European Union’s Horizon Europe research and innovation programme under Grant Agreement No. 101081369 (SPARCCLE). We also thank the two anonymous reviewers for providing helpful feedback that greatly improved this manuscript.","volume":4,"date_created":"2025-07-31T14:03:16Z","publisher":"IOP Publishing","publication_identifier":{"eissn":["2752-5295"]},"ec_funded":1,"OA_place":"publisher","file_date_updated":"2025-08-04T07:38:14Z","scopus_import":"1","corr_author":"1","has_accepted_license":"1"},{"publication":"Computational and Structural Biotechnology Journal","external_id":{"isi":["001583543100001"]},"article_processing_charge":"Yes","PlanS_conform":"1","citation":{"ama":"Vedula S, Bronstein AM, Marx A. Improving prediction accuracy in chimeric proteins with windowed multiple sequence alignment. <i>Computational and Structural Biotechnology Journal</i>. 2025;27:3292-3298. doi:<a href=\"https://doi.org/10.1016/j.csbj.2025.07.039\">10.1016/j.csbj.2025.07.039</a>","short":"S. Vedula, A.M. Bronstein, A. Marx, Computational and Structural Biotechnology Journal 27 (2025) 3292–3298.","chicago":"Vedula, Sanketh, Alex M. Bronstein, and Ailie Marx. “Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment.” <i>Computational and Structural Biotechnology Journal</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.csbj.2025.07.039\">https://doi.org/10.1016/j.csbj.2025.07.039</a>.","mla":"Vedula, Sanketh, et al. “Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment.” <i>Computational and Structural Biotechnology Journal</i>, vol. 27, Elsevier, 2025, pp. 3292–98, doi:<a href=\"https://doi.org/10.1016/j.csbj.2025.07.039\">10.1016/j.csbj.2025.07.039</a>.","ieee":"S. Vedula, A. M. Bronstein, and A. Marx, “Improving prediction accuracy in chimeric proteins with windowed multiple sequence alignment,” <i>Computational and Structural Biotechnology Journal</i>, vol. 27. Elsevier, pp. 3292–3298, 2025.","ista":"Vedula S, Bronstein AM, Marx A. 2025. Improving prediction accuracy in chimeric proteins with windowed multiple sequence alignment. Computational and Structural Biotechnology Journal. 27, 3292–3298.","apa":"Vedula, S., Bronstein, A. M., &#38; Marx, A. (2025). Improving prediction accuracy in chimeric proteins with windowed multiple sequence alignment. <i>Computational and Structural Biotechnology Journal</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.csbj.2025.07.039\">https://doi.org/10.1016/j.csbj.2025.07.039</a>"},"OA_type":"gold","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20100","year":"2025","doi":"10.1016/j.csbj.2025.07.039","quality_controlled":"1","intvolume":"        27","abstract":[{"lang":"eng","text":"A key step in protein structure prediction involves the detection of co-evolving pairs of residues, a signal for spatial proximity. This information is gleaned from multiple sequence alignment and underscores Alphafold’s structure prediction for almost every known protein. A simple means to create proteins beyond those found in nature, is by unnaturally fusing together two known proteins or protein parts. Here we demonstrate that structured peptides are predicted with significantly reduced accuracy when added to the terminal ends of scaffold proteins. Appending the multiple sequence alignment for the individual peptide tags to that of the scaffold protein often restores prediction accuracy. This work suggests that this windowed multiple sequence alignment approach can be a useful tool for predicting the structure of fused, chimeric proteins."}],"publication_status":"published","author":[{"first_name":"Sanketh","last_name":"Vedula","id":"94f2fe44-70fa-11f0-b76b-92922c09452b","full_name":"Vedula, Sanketh"},{"id":"58f3726e-7cba-11ef-ad8b-e6e8cb3904e6","full_name":"Bronstein, Alexander","last_name":"Bronstein","orcid":"0000-0001-9699-8730","first_name":"Alexander"},{"first_name":"Ailie","full_name":"Marx, Ailie","last_name":"Marx"}],"fulldoi":"https://doi.org/10.1016/j.csbj.2025.07.039","isi":1,"oa_version":"Published Version","date_published":"2025-06-27T00:00:00Z","related_material":{"record":[{"id":"20103","relation":"software","status":"public"}],"link":[{"url":"https://github.com/sankethvedula/AFChimera","relation":"software"}]},"day":"27","oa":1,"title":"Improving prediction accuracy in chimeric proteins with windowed multiple sequence alignment","DOAJ_listed":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2025-11-27T14:09:59Z","publication_identifier":{"eissn":["2001-0370"]},"publisher":"Elsevier","has_accepted_license":"1","scopus_import":"1","file_date_updated":"2025-08-04T06:25:23Z","OA_place":"publisher","file":[{"content_type":"application/pdf","relation":"main_file","file_size":6609770,"file_id":"20104","checksum":"78d01f30fc1dc11dd2bd1d7bb7ac8a62","date_updated":"2025-08-04T06:25:23Z","success":1,"date_created":"2025-08-04T06:25:23Z","access_level":"open_access","file_name":"2025_CompStrucBiotechJour_Vedula.pdf","creator":"dernst"}],"language":[{"iso":"eng"}],"department":[{"_id":"AlBr"}],"volume":27,"acknowledgement":"AM acknowledges the financial support of the Helmsley Fellowships Program for Sustainability and Health. AMB is supported by the Schmidt Chair in Artificial Intelligence.","article_type":"original","date_created":"2025-08-03T22:01:31Z","page":"3292-3298","type":"journal_article","month":"06","ddc":["000","570"]},{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","_id":"20102","OA_type":"hybrid","year":"2025","publication":"Molecular Ecology","article_number":"e70025","citation":{"ama":"Raffini F, De Jode A, Johannesson K, et al. Phenotypic divergence and genomic architecture between parallel ecotypes at two different points on the speciation continuum in a marine snail. <i>Molecular Ecology</i>. 2025;34(21). doi:<a href=\"https://doi.org/10.1111/mec.70025\">10.1111/mec.70025</a>","ieee":"F. Raffini <i>et al.</i>, “Phenotypic divergence and genomic architecture between parallel ecotypes at two different points on the speciation continuum in a marine snail,” <i>Molecular Ecology</i>, vol. 34, no. 21. Wiley, 2025.","ista":"Raffini F, De Jode A, Johannesson K, Faria R, Zagrodzka ZB, Westram AM, Galindo J, Rolán-Alvarez E, Butlin RK. 2025. Phenotypic divergence and genomic architecture between parallel ecotypes at two different points on the speciation continuum in a marine snail. Molecular Ecology. 34(21), e70025.","apa":"Raffini, F., De Jode, A., Johannesson, K., Faria, R., Zagrodzka, Z. B., Westram, A. M., … Butlin, R. K. (2025). Phenotypic divergence and genomic architecture between parallel ecotypes at two different points on the speciation continuum in a marine snail. <i>Molecular Ecology</i>. Wiley. <a href=\"https://doi.org/10.1111/mec.70025\">https://doi.org/10.1111/mec.70025</a>","mla":"Raffini, Francesca, et al. “Phenotypic Divergence and Genomic Architecture between Parallel Ecotypes at Two Different Points on the Speciation Continuum in a Marine Snail.” <i>Molecular Ecology</i>, vol. 34, no. 21, e70025, Wiley, 2025, doi:<a href=\"https://doi.org/10.1111/mec.70025\">10.1111/mec.70025</a>.","chicago":"Raffini, Francesca, Aurélien De Jode, Kerstin Johannesson, Rui Faria, Zuzanna B. Zagrodzka, Anja M Westram, Juan Galindo, Emilio Rolán-Alvarez, and Roger K. Butlin. “Phenotypic Divergence and Genomic Architecture between Parallel Ecotypes at Two Different Points on the Speciation Continuum in a Marine Snail.” <i>Molecular Ecology</i>. Wiley, 2025. <a href=\"https://doi.org/10.1111/mec.70025\">https://doi.org/10.1111/mec.70025</a>.","short":"F. Raffini, A. De Jode, K. Johannesson, R. Faria, Z.B. Zagrodzka, A.M. Westram, J. Galindo, E. Rolán-Alvarez, R.K. Butlin, Molecular Ecology 34 (2025)."},"external_id":{"isi":["001538172800001"]},"article_processing_charge":"Yes (in subscription journal)","PlanS_conform":"1","issue":"21","author":[{"first_name":"Francesca","full_name":"Raffini, Francesca","last_name":"Raffini"},{"full_name":"De Jode, Aurélien","last_name":"De Jode","first_name":"Aurélien"},{"first_name":"Kerstin","last_name":"Johannesson","full_name":"Johannesson, Kerstin"},{"first_name":"Rui","full_name":"Faria, Rui","last_name":"Faria"},{"last_name":"Zagrodzka","full_name":"Zagrodzka, Zuzanna B.","first_name":"Zuzanna B."},{"last_name":"Westram","id":"3C147470-F248-11E8-B48F-1D18A9856A87","full_name":"Westram, Anja M","first_name":"Anja M","orcid":"0000-0003-1050-4969"},{"first_name":"Juan","full_name":"Galindo, Juan","last_name":"Galindo"},{"full_name":"Rolán-Alvarez, Emilio","last_name":"Rolán-Alvarez","first_name":"Emilio"},{"full_name":"Butlin, Roger K.","last_name":"Butlin","first_name":"Roger K."}],"publication_status":"published","intvolume":"        34","abstract":[{"lang":"eng","text":"Speciation is rarely observable directly. A way forward is to compare pairs of ecotypes that evolved in parallel in similar contexts but have reached different degrees of reproductive isolation. Such comparisons are possible in the marine snail Littorina saxatilis by contrasting barriers to gene flow between parallel ecotypes in Spain and Sweden. In both countries, divergent ecotypes have evolved to withstand either crab predation or wave action. Here, we explore transects spanning contact zones between the Crab and the Wave ecotypes using low-coverage whole-genome sequencing, morphological and behavioural traits. Despite parallel phenotypic divergence, distinct patterns of differentiation between the ecotypes emerged: a continuous cline in Sweden indicating a weak barrier to gene flow, but two highly genetically and phenotypically divergent, and partly spatially overlapping clusters in Spain suggesting a much stronger barrier to gene flow. The absence of Spanish early-generation hybrids supported strong isolation, but a low level of gene flow is evident from molecular data. In both countries, highly differentiated loci were located in both shared and country-specific chromosomal inversions but were also present in collinear regions. Despite being considered the same species and showing similar levels of phenotypic divergence, the Spanish ecotypes are much closer to full reproductive isolation than the Swedish ones. Barriers to gene flow of very different strengths between ecotypes within the same species might be explained by dissimilarities in the spatial arrangement of habitats, the selection gradients or the ages of the systems."}],"fulldoi":"https://doi.org/10.1111/mec.70025","oa_version":"Published Version","isi":1,"date_published":"2025-11-01T00:00:00Z","doi":"10.1111/mec.70025","quality_controlled":"1","title":"Phenotypic divergence and genomic architecture between parallel ecotypes at two different points on the speciation continuum in a marine snail","date_updated":"2025-12-30T09:25:45Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"day":"01","oa":1,"language":[{"iso":"eng"}],"department":[{"_id":"NiBa"}],"file":[{"date_created":"2025-12-30T09:25:17Z","access_level":"open_access","success":1,"date_updated":"2025-12-30T09:25:17Z","creator":"dernst","file_name":"2025_MolecEcology_Raffini.pdf","relation":"main_file","content_type":"application/pdf","checksum":"ec01edda64cfbc6cbc8adf300f719644","file_id":"20906","file_size":2767745}],"month":"11","type":"journal_article","ddc":["570"],"article_type":"original","acknowledgement":"This study was supported by European Research Council grant 693030-BARRIERS to RKB; the Swedish Research Council (grant number 2021-04191) to KJ; the Portuguese Foundation for Science and Technology (FCT: 2020.00275.CEECIND and PTDC/BIA-EVL/1614/2021) to RF; grant PID2022-137935NB-I00 by MICIU/AEI/ 10.13039/501100011033/and ERDF/EU (ED431C 2020-05) to JG, grant PID2021-124930NB-I00 funded by MICIU/AEI/ 10.13039/501100011033/and ERDF/EU to ERA, Xunta de Galicia (ED431C 2024/22), Centro singular de Investigación de Galicia accreditation 2024-2027 (ED431G 2023/07), ‘ERDF A way of making Europe’ and Norwegian Research Council RCN, project 315287 to AMW.","volume":34,"date_created":"2025-08-03T22:01:31Z","publisher":"Wiley","publication_identifier":{"issn":["0962-1083"],"eissn":["1365-294X"]},"file_date_updated":"2025-12-30T09:25:17Z","OA_place":"publisher","scopus_import":"1","has_accepted_license":"1"},{"citation":{"mla":"Vedula, Sanketh, et al. <i>Replication Data for: “Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment.”</i> Harvard Dataverse, 2025, doi:<a href=\"https://doi.org/10.7910/DVN/DYEBVM\">10.7910/DVN/DYEBVM</a>.","chicago":"Vedula, Sanketh, Alex M. Bronstein, and Ailie Marx. “Replication Data for: ‘Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment.’” Harvard Dataverse, 2025. <a href=\"https://doi.org/10.7910/DVN/DYEBVM\">https://doi.org/10.7910/DVN/DYEBVM</a>.","short":"S. Vedula, A.M. Bronstein, A. Marx, (2025).","ieee":"S. Vedula, A. M. Bronstein, and A. Marx, “Replication Data for: ‘Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment.’” Harvard Dataverse, 2025.","ista":"Vedula S, Bronstein AM, Marx A. 2025. Replication Data for: ‘Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment’, Harvard Dataverse, <a href=\"https://doi.org/10.7910/DVN/DYEBVM\">10.7910/DVN/DYEBVM</a>.","apa":"Vedula, S., Bronstein, A. M., &#38; Marx, A. (2025). Replication Data for: “Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment.” Harvard Dataverse. <a href=\"https://doi.org/10.7910/DVN/DYEBVM\">https://doi.org/10.7910/DVN/DYEBVM</a>","ama":"Vedula S, Bronstein AM, Marx A. Replication Data for: “Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment.” 2025. doi:<a href=\"https://doi.org/10.7910/DVN/DYEBVM\">10.7910/DVN/DYEBVM</a>"},"oa":1,"article_processing_charge":"No","day":"27","related_material":{"record":[{"relation":"used_for_analysis_in","id":"20100","status":"public"}]},"date_updated":"2025-11-27T14:09:58Z","tmp":{"image":"/images/cc_0.png","name":"Creative Commons Public Domain Dedication (CC0 1.0)","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","short":"CC0 (1.0)"},"year":"2025","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","title":"Replication Data for: \"Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment\"","_id":"20103","OA_place":"repository","has_accepted_license":"1","publisher":"Harvard Dataverse","doi":"10.7910/DVN/DYEBVM","fulldoi":"https://doi.org/10.7910/DVN/DYEBVM","oa_version":"Published Version","date_published":"2025-06-27T00:00:00Z","type":"research_data_reference","ddc":["000"],"month":"06","license":"https://creativecommons.org/publicdomain/zero/1.0/","date_created":"2025-08-04T06:18:55Z","author":[{"first_name":"Sanketh","id":"94f2fe44-70fa-11f0-b76b-92922c09452b","full_name":"Vedula, Sanketh","last_name":"Vedula"},{"orcid":"0000-0001-9699-8730","first_name":"Alexander","full_name":"Bronstein, Alexander","id":"58f3726e-7cba-11ef-ad8b-e6e8cb3904e6","last_name":"Bronstein"},{"full_name":"Marx, Ailie","last_name":"Marx","first_name":"Ailie"}],"main_file_link":[{"url":"https://doi.org/10.7910/DVN/DYEBVM","open_access":"1"}],"department":[{"_id":"AlBr"}],"abstract":[{"text":"Official implementation, windowed MSAs, and the predictions as reported in the manuscript titled \"Improving Prediction Accuracy in Chimeric Proteins with Windowed Multiple Sequence Alignment\". (2025-06-27)","lang":"eng"}]},{"doi":"10.5281/ZENODO.13988679","project":[{"grant_number":"101034413","name":"IST-BRIDGE: International postdoctoral program","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"}],"fulldoi":"https://doi.org/10.5281/ZENODO.13988679","date_published":"2025-05-21T00:00:00Z","oa_version":"Published Version","author":[{"first_name":"Yi-Ling","orcid":"0000-0001-9281-3479","last_name":"Hwong","id":"1217aa61-4dd1-11ec-9ac3-f2ba3f17ee22","full_name":"Hwong, Yi-Ling"},{"first_name":"Edward","last_name":"Byers","full_name":"Byers, Edward"},{"first_name":"Michaela","last_name":"Werning","full_name":"Werning, Michaela"},{"first_name":"Yann","full_name":"Quilcaille, Yann","last_name":"Quilcaille"}],"abstract":[{"lang":"eng","text":"This repository contains the data and scripts required to reproduce the results of the manuscript \"Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages\" submitted to the Environmental Research Climate Journal (ERCL). "}],"citation":{"chicago":"Hwong, Yi-Ling, Edward Byers, Michaela Werning, and Yann Quilcaille. “Data - Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages.” Zenodo, 2025. <a href=\"https://doi.org/10.5281/ZENODO.13988679\">https://doi.org/10.5281/ZENODO.13988679</a>.","mla":"Hwong, Yi-Ling, et al. <i>Data - Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages</i>. Zenodo, 2025, doi:<a href=\"https://doi.org/10.5281/ZENODO.13988679\">10.5281/ZENODO.13988679</a>.","short":"Y.-L. Hwong, E. Byers, M. Werning, Y. Quilcaille, (2025).","ista":"Hwong Y-L, Byers E, Werning M, Quilcaille Y. 2025. Data - Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages, Zenodo, <a href=\"https://doi.org/10.5281/ZENODO.13988679\">10.5281/ZENODO.13988679</a>.","apa":"Hwong, Y.-L., Byers, E., Werning, M., &#38; Quilcaille, Y. (2025). Data - Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages. Zenodo. <a href=\"https://doi.org/10.5281/ZENODO.13988679\">https://doi.org/10.5281/ZENODO.13988679</a>","ieee":"Y.-L. Hwong, E. Byers, M. Werning, and Y. Quilcaille, “Data - Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages.” Zenodo, 2025.","ama":"Hwong Y-L, Byers E, Werning M, Quilcaille Y. Data - Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages. 2025. doi:<a href=\"https://doi.org/10.5281/ZENODO.13988679\">10.5281/ZENODO.13988679</a>"},"article_processing_charge":"No","year":"2025","_id":"20107","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","OA_type":"green","corr_author":"1","OA_place":"repository","has_accepted_license":"1","publisher":"Zenodo","ec_funded":1,"month":"05","type":"research_data_reference","ddc":["550"],"date_created":"2025-08-04T07:34:39Z","department":[{"_id":"CaMu"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5281/zenodo.15409324"}],"oa":1,"day":"21","related_material":{"record":[{"relation":"used_in_publication","id":"20098","status":"public"}]},"date_updated":"2025-08-04T07:46:33Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"title":"Data - Sustainable Development Key to Limiting Climate Change-Driven Wildfire Damages"},{"abstract":[{"lang":"eng","text":"This criteria catalogue and the accompanying assessment questions were developed by a working group of KEMÖ (Kooperation E-Medien Österreich, the Austrian Academic Library Consortium). They are intended to support research institutions and organisations in the evaluation of Open Science Infrastructures. The 20 criteria outlined in the catalogue provide a structured basis for making informed decisions regarding the financial support of these infrastructures.\r\n\r\nThe assessment questions are intended to be completed by Open Science Infrastructures and can be shared with them accordingly."}],"language":[{"iso":"eng"}],"author":[{"first_name":"Paul","full_name":"Gredler, Paul","last_name":"Gredler"},{"last_name":"Kaier","full_name":"Kaier, Christian","first_name":"Christian"},{"orcid":"0000-0002-6026-4409","first_name":"Patrick","id":"2EBD1598-F248-11E8-B48F-1D18A9856A87","full_name":"Danowski, Patrick","last_name":"Danowski"},{"full_name":"Zoyer, Michael","last_name":"Zoyer","first_name":"Michael"},{"full_name":"Rieck, Katharina","last_name":"Rieck","first_name":"Katharina"},{"full_name":"Ferus, Andreas","last_name":"Ferus","first_name":"Andreas"},{"last_name":"Rosenberger","full_name":"Rosenberger, Elisabeth","first_name":"Elisabeth"},{"last_name":"Löffler","full_name":"Löffler, Alexander","first_name":"Alexander"},{"full_name":"Hofer, Lisa","last_name":"Hofer","first_name":"Lisa"},{"last_name":"Still","full_name":"Still, Laura","first_name":"Laura"}],"main_file_link":[{"url":"https://doi.org/10.5281/zenodo.15269364","open_access":"1"}],"department":[{"_id":"E-Lib"}],"publication_status":"published","date_created":"2025-08-07T11:10:14Z","fulldoi":"https://doi.org/10.5281/zenodo.15269364","date_published":"2025-08-07T00:00:00Z","oa_version":"Published Version","type":"working_paper","ddc":["020"],"month":"08","doi":"10.5281/zenodo.15269364","publisher":"Zenodo","has_accepted_license":"1","OA_place":"publisher","OA_type":"gold","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures","_id":"20146","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"year":"2025","date_updated":"2025-08-11T07:20:03Z","day":"07","article_processing_charge":"No","citation":{"ista":"Gredler P, Kaier C, Danowski P, Zoyer M, Rieck K, Ferus A, Rosenberger E, Löffler A, Hofer L, Still L. 2025. Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures, Zenodo,p.","apa":"Gredler, P., Kaier, C., Danowski, P., Zoyer, M., Rieck, K., Ferus, A., … Still, L. (2025). <i>Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures</i>. Zenodo. <a href=\"https://doi.org/10.5281/zenodo.15269364\">https://doi.org/10.5281/zenodo.15269364</a>","ieee":"P. Gredler <i>et al.</i>, <i>Catalogue of criteria for assessing the funding eligibility of Open Science infrastructures</i>. Zenodo, 2025.","short":"P. Gredler, C. Kaier, P. Danowski, M. Zoyer, K. Rieck, A. Ferus, E. Rosenberger, A. Löffler, L. Hofer, L. Still, Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures, Zenodo, 2025.","mla":"Gredler, Paul, et al. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo, 2025, doi:<a href=\"https://doi.org/10.5281/zenodo.15269364\">10.5281/zenodo.15269364</a>.","chicago":"Gredler, Paul, Christian Kaier, Patrick Danowski, Michael Zoyer, Katharina Rieck, Andreas Ferus, Elisabeth Rosenberger, Alexander Löffler, Lisa Hofer, and Laura Still. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo, 2025. <a href=\"https://doi.org/10.5281/zenodo.15269364\">https://doi.org/10.5281/zenodo.15269364</a>.","ama":"Gredler P, Kaier C, Danowski P, et al. <i>Catalogue of Criteria for Assessing the Funding Eligibility of Open Science Infrastructures</i>. Zenodo; 2025. doi:<a href=\"https://doi.org/10.5281/zenodo.15269364\">10.5281/zenodo.15269364</a>"},"oa":1},{"date_updated":"2026-04-28T13:26:50Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"title":"Coordination of protrusive forces in immune cell migration ","oa":1,"day":"08","related_material":{"record":[{"relation":"part_of_dissertation","id":"10703","status":"public"},{"id":"20082","relation":"part_of_dissertation","status":"public"}]},"month":"08","ddc":["570"],"type":"dissertation","date_created":"2025-08-08T09:18:02Z","page":"114","acknowledgement":"I would like to acknowledge the\r\nfinancial support of the European Research Council through the ERC-SyG grant “Pushing from\r\nwithin: Control of cell shape, integrity and motility by cytoskeletal pushing forces”\r\n(01071793), which made this research possible. ","department":[{"_id":"GradSch"},{"_id":"MiSi"}],"language":[{"iso":"eng"}],"file":[{"file_name":"2025_ReisRodrigues_Patricia_Thesis.pdf","creator":"prodrigu","success":1,"date_updated":"2025-08-27T12:59:10Z","date_created":"2025-08-27T12:59:10Z","access_level":"open_access","file_id":"20232","file_size":63885565,"checksum":"fda8a1070667c3562263f4867609b41b","content_type":"application/pdf","relation":"main_file"},{"creator":"prodrigu","file_name":"2025_ReisRodrigues_Patricia_Thesis.docx","date_created":"2025-08-27T13:00:30Z","access_level":"closed","date_updated":"2025-08-27T13:02:28Z","checksum":"e8b65affcbce846a926454df4b2867b9","file_size":50483434,"file_id":"20233","relation":"source_file","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document"}],"corr_author":"1","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"NanoFab"}],"OA_place":"publisher","file_date_updated":"2025-08-27T13:02:28Z","alternative_title":["ISTA Thesis"],"has_accepted_license":"1","publisher":"Institute of Science and Technology Austria","supervisor":[{"first_name":"Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"publication_identifier":{"issn":["2663-337X"]},"year":"2025","degree_awarded":"PhD","_id":"20149","status":"public","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","citation":{"ieee":"P. Dos Reis Rodrigues, “Coordination of protrusive forces in immune cell migration ,” Institute of Science and Technology Austria, 2025.","ista":"Dos Reis Rodrigues P. 2025. Coordination of protrusive forces in immune cell migration . Institute of Science and Technology Austria.","apa":"Dos Reis Rodrigues, P. (2025). <i>Coordination of protrusive forces in immune cell migration </i>. Institute of Science and Technology Austria. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>","short":"P. Dos Reis Rodrigues, Coordination of Protrusive Forces in Immune Cell Migration , Institute of Science and Technology Austria, 2025.","chicago":"Dos Reis Rodrigues, Patricia. “Coordination of Protrusive Forces in Immune Cell Migration .” Institute of Science and Technology Austria, 2025. <a href=\"https://doi.org/10.15479/AT-ISTA-20149\">https://doi.org/10.15479/AT-ISTA-20149</a>.","mla":"Dos Reis Rodrigues, Patricia. <i>Coordination of Protrusive Forces in Immune Cell Migration </i>. Institute of Science and Technology Austria, 2025, doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>.","ama":"Dos Reis Rodrigues P. Coordination of protrusive forces in immune cell migration . 2025. doi:<a href=\"https://doi.org/10.15479/AT-ISTA-20149\">10.15479/AT-ISTA-20149</a>"},"article_processing_charge":"No","project":[{"_id":"bd91e723-d553-11ed-ba76-fe7eeb2185fd","name":"Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces","grant_number":"101071793"}],"fulldoi":"https://doi.org/10.15479/AT-ISTA-20149","date_published":"2025-08-08T00:00:00Z","oa_version":"Published Version","publication_status":"published","author":[{"orcid":"0000-0003-1681-508X","first_name":"Patricia","id":"26E95904-5160-11E9-9C0B-C5B0DC97E90F","full_name":"Dos Reis Rodrigues, Patricia","last_name":"Dos Reis Rodrigues"}],"abstract":[{"lang":"eng","text":"Immune responses depend on the coordinated and efficient migration of leukocytes. These\r\ncells, which are embedded and tightly confined within tissues, must navigate and traverse\r\ndiverse and complex three-dimensional environments. Leukocytes adapt their locomotory\r\nbehavior to the mechanical, geometrical, and biochemical characteristics of their\r\nsurroundings. In low-density environments, where the pore size of the interstitial matrix\r\nallows free passage, these cells position the nucleus directly behind the lamellipodium, the\r\nprotrusive actin structure that forms the leading front of the cell. In this configuration, they\r\nuse the nucleus as a gauge to identify the path of least resistance.\r\nHere, we show that in high-density environments, where the pore size precludes free passage\r\nof the cell body, leukocytes reposition the microtubule-organizing center (MTOC) and\r\nassociated organelles in front of the nucleus. In this configuration, they use actin structures\r\nprotruding orthogonally to the direction of migration in order to open a path for the cell body.\r\nWe identify two distinct actin populations that serve this purpose at different subcellular\r\nlocalizations. At the leading edge, local indentation of the plasma membrane leads to\r\nrecruitment of the Wiskott-Aldrich syndrome protein (WASp), which, via Arp2/3, results in\r\nthe formation of individual actin foci. At the cell body, actin polymerization is triggered by\r\nDOCK8, a Cdc42 exchange factor, resulting in the formation of a central actin pool.\r\nWe demonstrate that the central and peripheral actin pools are functionally communicating\r\nand that depletion of the central actin pool leads to increased actin accumulation at the cell\r\nfront, resulting in excessive extension of the leading edge."}],"doi":"10.15479/AT-ISTA-20149"},{"title":"How to construct explicit decay rates for kinetic Fokker–Planck equations?","date_updated":"2025-11-05T13:51:40Z","day":"01","oa":1,"department":[{"_id":"JaMa"}],"main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2302.14506","open_access":"1"}],"arxiv":1,"language":[{"iso":"eng"}],"type":"journal_article","month":"08","date_created":"2025-08-10T22:01:29Z","page":"3587-3622","volume":57,"article_type":"original","acknowledgement":"The first author was funded by the European Union's Horizon 2020 research andinnovation program under the Marie Sklodowska-Curie grant agreements 754362 and 101034413,and partially by Project EFI (ANR-17-CE40-0030) of the French National Research Agency (ANR).The work of the second author was partially funded by the European Research Council (ERC) underthe European Union's Horizon 2020 research and innovation programme (grant agreement 810367),and by the Agence Nationale de la Recherche under grants ANR-19-CE40-0010 (QuAMProcs) andANR-21-CE40-0006 (SINEQ).","publisher":"Society for Industrial and Applied Mathematics","ec_funded":1,"publication_identifier":{"eissn":["1095-7154"],"issn":["0036-1410"]},"corr_author":"1","scopus_import":"1","OA_place":"repository","_id":"20155","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","OA_type":"green","year":"2025","publication":"SIAM Journal on Mathematical Analysis","citation":{"ama":"Brigati G, Stoltz G. How to construct explicit decay rates for kinetic Fokker–Planck equations? <i>SIAM Journal on Mathematical Analysis</i>. 2025;57(4):3587-3622. doi:<a href=\"https://doi.org/10.1137/24M1700351\">10.1137/24M1700351</a>","ista":"Brigati G, Stoltz G. 2025. How to construct explicit decay rates for kinetic Fokker–Planck equations? SIAM Journal on Mathematical Analysis. 57(4), 3587–3622.","apa":"Brigati, G., &#38; Stoltz, G. (2025). How to construct explicit decay rates for kinetic Fokker–Planck equations? <i>SIAM Journal on Mathematical Analysis</i>. Society for Industrial and Applied Mathematics. <a href=\"https://doi.org/10.1137/24M1700351\">https://doi.org/10.1137/24M1700351</a>","ieee":"G. Brigati and G. Stoltz, “How to construct explicit decay rates for kinetic Fokker–Planck equations?,” <i>SIAM Journal on Mathematical Analysis</i>, vol. 57, no. 4. Society for Industrial and Applied Mathematics, pp. 3587–3622, 2025.","short":"G. Brigati, G. Stoltz, SIAM Journal on Mathematical Analysis 57 (2025) 3587–3622.","chicago":"Brigati, Giovanni, and Gabriel Stoltz. “How to Construct Explicit Decay Rates for Kinetic Fokker–Planck Equations?” <i>SIAM Journal on Mathematical Analysis</i>. Society for Industrial and Applied Mathematics, 2025. <a href=\"https://doi.org/10.1137/24M1700351\">https://doi.org/10.1137/24M1700351</a>.","mla":"Brigati, Giovanni, and Gabriel Stoltz. “How to Construct Explicit Decay Rates for Kinetic Fokker–Planck Equations?” <i>SIAM Journal on Mathematical Analysis</i>, vol. 57, no. 4, Society for Industrial and Applied Mathematics, 2025, pp. 3587–622, doi:<a href=\"https://doi.org/10.1137/24M1700351\">10.1137/24M1700351</a>."},"article_processing_charge":"No","external_id":{"isi":["001550830900006"],"arxiv":["2302.14506"]},"issue":"4","publication_status":"published","author":[{"first_name":"Giovanni","last_name":"Brigati","full_name":"Brigati, Giovanni","id":"63ff57e8-1fbb-11ee-88f2-f558ffc59cf1"},{"first_name":"Gabriel","full_name":"Stoltz, Gabriel","last_name":"Stoltz"}],"intvolume":"        57","abstract":[{"lang":"eng","text":"We study time averages for the norm of solutions to kinetic Fokker–Planck equations associated with general Hamiltonians. We provide fully explicit and constructive decay estimates for systems subject to a confining potential, allowing fat-tail, subexponential and (super-)exponential local equilibria, which also include the classic Maxwellian case. The key step in our estimates is a modified Poincaré inequality, obtained via a Lions–Poincaré inequality and an averaging lemma."}],"fulldoi":"https://doi.org/10.1137/24M1700351","oa_version":"Preprint","date_published":"2025-08-01T00:00:00Z","isi":1,"project":[{"name":"IST-BRIDGE: International postdoctoral program","grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","call_identifier":"H2020"}],"quality_controlled":"1","doi":"10.1137/24M1700351"},{"has_accepted_license":"1","file_date_updated":"2025-12-30T13:14:20Z","scopus_import":"1","OA_place":"publisher","corr_author":"1","publication_identifier":{"issn":["2214-5745"],"eissn":["2214-5753"]},"publisher":"Elsevier","volume":72,"acknowledgement":"This work was supported by an Austrian Research Fund (FWF) grant to B.V. (PAT 8748323) and by the Louisiana Board of Regents Research Competitiveness Subprogram (LEQSF(2025-28)-RD-A-20) to MAT.","article_type":"review","date_created":"2025-08-17T22:01:35Z","ddc":["570"],"type":"journal_article","month":"12","file":[{"access_level":"open_access","date_created":"2025-12-30T13:14:20Z","success":1,"date_updated":"2025-12-30T13:14:20Z","creator":"dernst","file_name":"2025_CurrOpinionInsectScience_Toups.pdf","relation":"main_file","content_type":"application/pdf","checksum":"262640abc34277686b56eb60102976f6","file_size":897079,"file_id":"20917"}],"language":[{"iso":"eng"}],"department":[{"_id":"BeVi"}],"oa":1,"day":"01","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2025-12-30T13:14:38Z","title":"Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation","doi":"10.1016/j.cois.2025.101411","quality_controlled":"1","date_published":"2025-12-01T00:00:00Z","fulldoi":"https://doi.org/10.1016/j.cois.2025.101411","oa_version":"Published Version","isi":1,"project":[{"_id":"8ed82125-16d5-11f0-9cad-fbcae312235b","grant_number":"PAT 8748323","name":"Sex chromosomes in evolution and development"}],"intvolume":"        72","abstract":[{"lang":"eng","text":"Sex chromosomes have evolved many times throughout the tree of life, and understanding what has shaped their unusual morphological, sequence, and regulatory features has been a long-standing goal. Most early insights into insect sex chromosome biology came from a few model species, such as the fruit fly Drosophila melanogaster, which limited broad-scale evolutionary inferences. More recently, extensive comparative genomics studies have uncovered several unexpected patterns, which we highlight in this review. First, we describe the conservation of the ancestral X chromosome over 450 million years but also its recurrent turnover (i.e. its reversal to an autosome when a new X chromosome arose) in at least one order. We then summarize classical and more recent findings on how insects modulate the expression of X-linked genes following the degradation of the Y chromosome and how the diverse mechanisms of dosage compensation identified may elucidate important principles of sex chromosome regulatory evolution."}],"author":[{"id":"4E099E4E-F248-11E8-B48F-1D18A9856A87","full_name":"Toups, Melissa A","last_name":"Toups","orcid":"0000-0002-9752-7380","first_name":"Melissa A"},{"last_name":"Vicoso","id":"49E1C5C6-F248-11E8-B48F-1D18A9856A87","full_name":"Vicoso, Beatriz","first_name":"Beatriz","orcid":"0000-0002-4579-8306"}],"publication_status":"published","external_id":{"isi":["001582424100001"]},"article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","citation":{"ama":"Toups MA, Vicoso B. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. 2025;72. doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>","ieee":"M. A. Toups and B. Vicoso, “Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation,” <i>Current Opinion in Insect Science</i>, vol. 72. Elsevier, 2025.","apa":"Toups, M. A., &#38; Vicoso, B. (2025). Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. <i>Current Opinion in Insect Science</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>","ista":"Toups MA, Vicoso B. 2025. Insect sex chromosome evolution: Conservation, turnover, and mechanisms of dosage compensation. Current Opinion in Insect Science. 72, 101411.","mla":"Toups, Melissa A., and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>, vol. 72, 101411, Elsevier, 2025, doi:<a href=\"https://doi.org/10.1016/j.cois.2025.101411\">10.1016/j.cois.2025.101411</a>.","chicago":"Toups, Melissa A, and Beatriz Vicoso. “Insect Sex Chromosome Evolution: Conservation, Turnover, and Mechanisms of Dosage Compensation.” <i>Current Opinion in Insect Science</i>. Elsevier, 2025. <a href=\"https://doi.org/10.1016/j.cois.2025.101411\">https://doi.org/10.1016/j.cois.2025.101411</a>.","short":"M.A. Toups, B. Vicoso, Current Opinion in Insect Science 72 (2025)."},"article_number":"101411","publication":"Current Opinion in Insect Science","year":"2025","OA_type":"hybrid","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20182"},{"file":[{"relation":"main_file","content_type":"application/pdf","checksum":"f28e73963ea1f55876d0d1afca0f706a","file_size":3775190,"file_id":"20261","access_level":"open_access","date_created":"2025-09-01T09:46:44Z","success":1,"date_updated":"2025-09-01T09:46:44Z","creator":"dernst","file_name":"2025_NatureComm_Segos.pdf"}],"language":[{"iso":"eng"}],"department":[{"_id":"CaHe"}],"acknowledgement":"We thank members of the Conradt lab, the Center for Cell and Molecular Dynamics (https://www.uclccmd.co.uk/) and T. Schedl for discussions and comments on the manuscript. We thank L. McGuinness for excellent technical support. Some strains were provided by the Caenorhabditis Genetics Center (CGC), which is funded by NIH Office of Research Infrastructure Programs (P40 OD010440). We thank Alex Hajnal (University of Zurich, Switzerland) and Andrew deMello (ETH Zurich, Switzerland) for their support of S.B. This work was supported by a predoctoral fellowship from the Studienstiftung des deutschen Volkes to NM, funds from UCL (Division of Biosciences, UCL LSM Capital Equipment Fund) to B.C., and a Wolfson Fellowship from the Royal Society (https://royalsociety.org/) to B.C. (RSWF\\R1\\180008), and the Biotechnology and Biological Sciences Research Council (https://bbsrc.ukri.org/) (BB/V007572/1 and BB/V015648/1to B.C.).","volume":16,"article_type":"original","pmid":1,"date_created":"2025-08-17T22:01:35Z","month":"08","type":"journal_article","ddc":["570"],"publication_identifier":{"eissn":["2041-1723"]},"publisher":"Springer Nature","has_accepted_license":"1","scopus_import":"1","file_date_updated":"2025-09-01T09:46:44Z","OA_place":"publisher","title":"Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo","DOAJ_listed":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2025-09-01T09:47:29Z","day":"04","oa":1,"intvolume":"        16","abstract":[{"lang":"eng","text":"The unequal segregation of organelles has been proposed to be an intrinsic mechanism that contributes to cell fate divergence during asymmetric cell division; however, in vivo evidence is sparse. Using super-resolution microscopy, we analysed the segregation of organelles during the division of the neuroblast QL.p in C. elegans larvae. QL.p divides to generate a daughter that survives, QL.pa, and a daughter that dies, QL.pp. We found that mitochondria segregate unequally by density and morphology and that this is dependent on mitochondrial dynamics. Furthermore, we found that mitochondrial density in QL.pp correlates with the time it takes QL.pp to die. We propose that low mitochondrial density in QL.pp promotes the cell death fate and ensures that QL.pp dies in a highly reproducible and timely manner. Our results provide in vivo evidence that the unequal segregation of mitochondria can contribute to cell fate divergence during asymmetric cell division in a developing animal."}],"publication_status":"published","author":[{"last_name":"Segos","full_name":"Segos, Ioannis","first_name":"Ioannis"},{"full_name":"Van Eeckhoven, Jens","last_name":"Van Eeckhoven","first_name":"Jens"},{"first_name":"Simon","last_name":"Berger","full_name":"Berger, Simon"},{"orcid":"0000-0002-6425-5788","first_name":"Nikhil","id":"C4D70E82-1081-11EA-B3ED-9A4C3DDC885E","full_name":"Mishra, Nikhil","last_name":"Mishra"},{"first_name":"Eric J.","last_name":"Lambie","full_name":"Lambie, Eric J."},{"last_name":"Conradt","full_name":"Conradt, Barbara","first_name":"Barbara"}],"oa_version":"Published Version","fulldoi":"https://doi.org/10.1038/s41467-025-62484-5","date_published":"2025-08-04T00:00:00Z","doi":"10.1038/s41467-025-62484-5","quality_controlled":"1","OA_type":"gold","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","_id":"20183","year":"2025","article_number":"7174","publication":"Nature Communications","external_id":{"pmid":["40759648"]},"PlanS_conform":"1","article_processing_charge":"Yes","citation":{"ieee":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E. J. Lambie, and B. Conradt, “Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo,” <i>Nature Communications</i>, vol. 16. Springer Nature, 2025.","ista":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. 2025. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. Nature Communications. 16, 7174.","apa":"Segos, I., Van Eeckhoven, J., Berger, S., Mishra, N., Lambie, E. J., &#38; Conradt, B. (2025). Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>","mla":"Segos, Ioannis, et al. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>, vol. 16, 7174, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>.","chicago":"Segos, Ioannis, Jens Van Eeckhoven, Simon Berger, Nikhil Mishra, Eric J. Lambie, and Barbara Conradt. “Unequal Segregation of Mitochondria during Asymmetric Cell Division Contributes to Cell Fate Divergence in Sister Cells in Vivo.” <i>Nature Communications</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41467-025-62484-5\">https://doi.org/10.1038/s41467-025-62484-5</a>.","short":"I. Segos, J. Van Eeckhoven, S. Berger, N. Mishra, E.J. Lambie, B. Conradt, Nature Communications 16 (2025).","ama":"Segos I, Van Eeckhoven J, Berger S, Mishra N, Lambie EJ, Conradt B. Unequal segregation of mitochondria during asymmetric cell division contributes to cell fate divergence in sister cells in vivo. <i>Nature Communications</i>. 2025;16. doi:<a href=\"https://doi.org/10.1038/s41467-025-62484-5\">10.1038/s41467-025-62484-5</a>"}},{"date_updated":"2025-09-30T14:18:46Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"title":"The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa","DOAJ_listed":"1","oa":1,"day":"02","ddc":["570"],"type":"journal_article","month":"08","volume":8,"article_type":"original","acknowledgement":"This work was supported by the Secretaría de Ciencia y Técnica (33620230100926CB), Universidad Nacional de Córdoba; and the Agencia Nacional de Promoción Científica y Técnica (PICT 2018-4527).\r\n\r\n","pmid":1,"date_created":"2025-08-17T22:01:35Z","language":[{"iso":"eng"}],"department":[{"_id":"PaSc"},{"_id":"GradSch"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s42003-025-08589-5"}],"scopus_import":"1","OA_place":"publisher","has_accepted_license":"1","publisher":"Springer Nature","publication_identifier":{"eissn":["2399-3642"]},"year":"2025","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","_id":"20184","OA_type":"gold","citation":{"ista":"Castell SD, Fernandez CM, Tumas IN, Margara LM, Miserendino MC, Ceschin DG, Pezza RJ, Monti MR. 2025. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. Communications Biology. 8, 1148.","apa":"Castell, S. D., Fernandez, C. M., Tumas, I. N., Margara, L. M., Miserendino, M. C., Ceschin, D. G., … Monti, M. R. (2025). The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. <i>Communications Biology</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s42003-025-08589-5\">https://doi.org/10.1038/s42003-025-08589-5</a>","ieee":"S. D. Castell <i>et al.</i>, “The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa,” <i>Communications Biology</i>, vol. 8. Springer Nature, 2025.","mla":"Castell, Sofía D., et al. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” <i>Communications Biology</i>, vol. 8, 1148, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1038/s42003-025-08589-5\">10.1038/s42003-025-08589-5</a>.","chicago":"Castell, Sofía D., Consuelo M. Fernandez, Ignacio N. Tumas, Lucía M. Margara, Maria C Miserendino, Danilo G. Ceschin, Roberto J. Pezza, and Mariela R. Monti. “The Low-Fidelity DNA Pol IV Accelerates Evolution of Pathogenicity Genes in Pseudomonas Aeruginosa.” <i>Communications Biology</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s42003-025-08589-5\">https://doi.org/10.1038/s42003-025-08589-5</a>.","short":"S.D. Castell, C.M. Fernandez, I.N. Tumas, L.M. Margara, M.C. Miserendino, D.G. Ceschin, R.J. Pezza, M.R. Monti, Communications Biology 8 (2025).","ama":"Castell SD, Fernandez CM, Tumas IN, et al. The low-fidelity DNA Pol IV accelerates evolution of pathogenicity genes in Pseudomonas aeruginosa. <i>Communications Biology</i>. 2025;8. doi:<a href=\"https://doi.org/10.1038/s42003-025-08589-5\">10.1038/s42003-025-08589-5</a>"},"external_id":{"isi":["001541878500001"],"pmid":["40753298"]},"article_processing_charge":"Yes","PlanS_conform":"1","publication":"Communications Biology","article_number":"1148","fulldoi":"https://doi.org/10.1038/s42003-025-08589-5","date_published":"2025-08-02T00:00:00Z","isi":1,"oa_version":"Published Version","publication_status":"published","author":[{"full_name":"Castell, Sofía D.","last_name":"Castell","first_name":"Sofía D."},{"last_name":"Fernandez","full_name":"Fernandez, Consuelo M.","first_name":"Consuelo M."},{"first_name":"Ignacio N.","full_name":"Tumas, Ignacio N.","last_name":"Tumas"},{"full_name":"Margara, Lucía M.","last_name":"Margara","first_name":"Lucía M."},{"id":"273e0cbd-72f0-11ef-b75a-f9f932e292fa","full_name":"Miserendino, Maria C","last_name":"Miserendino","first_name":"Maria C"},{"full_name":"Ceschin, Danilo G.","last_name":"Ceschin","first_name":"Danilo G."},{"last_name":"Pezza","full_name":"Pezza, Roberto J.","first_name":"Roberto J."},{"first_name":"Mariela R.","full_name":"Monti, Mariela R.","last_name":"Monti"}],"intvolume":"         8","abstract":[{"lang":"eng","text":"Specialized DNA polymerases facilitate various cellular processes. Despite extensive research, the mutagenic effects of these error-prone enzymes on genomes are not fully understood. Here we show that Pol IV promotes genomic instability in Pseudomonas aeruginosa by misincorporating oxidized guanine nucleotides. This activity led to a distinctive mutational signature, characterized by A-to-C transversions occurring preferentially at AT sites flanked by a 5’G and/or 3’C. Furthermore, Pol IV preferentially targeted pathogenicity genes located at specific chromosomal locations near the replication termination region and rRNA-encoding operons. Half of the mutation events catalyzed by Pol IV impaired gene function. This can be attributed to the bias of Pol IV for mutating codons with its preferred sequence contexts, leading to substitutions to unreactive alanine and glycine residues. Remarkably, mutation signatures identified for Pol IV were found in clinical isolate genomes of P. aeruginosa, providing compelling evidence for its role in genetic diversification during pathogen adaptation."}],"doi":"10.1038/s42003-025-08589-5","quality_controlled":"1"},{"publisher":"Springer Nature","publication_identifier":{"issn":["1050-6926"]},"ec_funded":1,"scopus_import":"1","file_date_updated":"2025-12-30T09:28:58Z","OA_place":"publisher","corr_author":"1","has_accepted_license":"1","arxiv":1,"language":[{"iso":"eng"}],"department":[{"_id":"VaKa"}],"file":[{"content_type":"application/pdf","relation":"main_file","file_size":484344,"file_id":"20907","checksum":"ed86500742b3fd93db3287558a630383","success":1,"date_updated":"2025-12-30T09:28:58Z","date_created":"2025-12-30T09:28:58Z","access_level":"open_access","file_name":"2025_JourGeomAnalysis_Tsodikovich.pdf","creator":"dernst"}],"month":"08","ddc":["510"],"type":"journal_article","volume":35,"acknowledgement":"The author would like to thank Corentin Fierobe, Vadim Kaloshin, Illya Koval and Yunzhe Li for useful discussions. The author would also like to thank the referee for useful remarks. Open access funding provided by Institute of Science and Technology (IST Austria). European Research Council (885707) Mr Daniel Tsodikovich","article_type":"original","date_created":"2025-08-17T22:01:35Z","day":"07","oa":1,"title":"Local rigidity for symplectic billiards","date_updated":"2025-12-30T09:29:27Z","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"doi":"10.1007/s12220-025-02148-4","quality_controlled":"1","publication_status":"published","author":[{"first_name":"Daniel","last_name":"Tsodikovich","full_name":"Tsodikovich, Daniel","id":"04531810-fb3e-11ef-87f0-800a4ce333db"}],"issue":"10","abstract":[{"lang":"eng","text":"We show a local rigidity result for the integrability of symplectic billiards. We prove that any domain which is close to an ellipse, and for which the symplectic billiard map is rationally integrable must be an ellipse as well. This is in spirit of the result of [2] for Birkhoff billiards."}],"intvolume":"        35","oa_version":"Published Version","fulldoi":"https://doi.org/10.1007/s12220-025-02148-4","date_published":"2025-08-07T00:00:00Z","isi":1,"project":[{"grant_number":"885707","name":"Spectral rigidity and integrability for billiards and geodesic flows","call_identifier":"H2020","_id":"9B8B92DE-BA93-11EA-9121-9846C619BF3A"}],"publication":"Journal of Geometric Analysis","article_number":"306","citation":{"ama":"Tsodikovich D. Local rigidity for symplectic billiards. <i>Journal of Geometric Analysis</i>. 2025;35(10). doi:<a href=\"https://doi.org/10.1007/s12220-025-02148-4\">10.1007/s12220-025-02148-4</a>","short":"D. Tsodikovich, Journal of Geometric Analysis 35 (2025).","mla":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” <i>Journal of Geometric Analysis</i>, vol. 35, no. 10, 306, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1007/s12220-025-02148-4\">10.1007/s12220-025-02148-4</a>.","chicago":"Tsodikovich, Daniel. “Local Rigidity for Symplectic Billiards.” <i>Journal of Geometric Analysis</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s12220-025-02148-4\">https://doi.org/10.1007/s12220-025-02148-4</a>.","ista":"Tsodikovich D. 2025. Local rigidity for symplectic billiards. Journal of Geometric Analysis. 35(10), 306.","apa":"Tsodikovich, D. (2025). Local rigidity for symplectic billiards. <i>Journal of Geometric Analysis</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s12220-025-02148-4\">https://doi.org/10.1007/s12220-025-02148-4</a>","ieee":"D. Tsodikovich, “Local rigidity for symplectic billiards,” <i>Journal of Geometric Analysis</i>, vol. 35, no. 10. Springer Nature, 2025."},"external_id":{"isi":["001546433200002"],"arxiv":["2501.08849"]},"PlanS_conform":"1","article_processing_charge":"Yes (via OA deal)","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20185","OA_type":"hybrid","year":"2025"},{"article_number":"30","publication":"Acta Informatica","external_id":{"isi":["001546115300001"]},"article_processing_charge":"Yes (via OA deal)","PlanS_conform":"1","citation":{"ama":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. Gray-box runtime enforcement of hyperproperties. <i>Acta Informatica</i>. 2025;62(3). doi:<a href=\"https://doi.org/10.1007/s00236-025-00502-1\">10.1007/s00236-025-00502-1</a>","apa":"Hsu, T. H., Oliveira da Costa, A. A., Wintenberg, A., Bartocci, E., &#38; Bonakdarpour, B. (2025). Gray-box runtime enforcement of hyperproperties. <i>Acta Informatica</i>. Springer Nature. <a href=\"https://doi.org/10.1007/s00236-025-00502-1\">https://doi.org/10.1007/s00236-025-00502-1</a>","ista":"Hsu TH, Oliveira da Costa AA, Wintenberg A, Bartocci E, Bonakdarpour B. 2025. Gray-box runtime enforcement of hyperproperties. Acta Informatica. 62(3), 30.","ieee":"T. H. Hsu, A. A. Oliveira da Costa, A. Wintenberg, E. Bartocci, and B. Bonakdarpour, “Gray-box runtime enforcement of hyperproperties,” <i>Acta Informatica</i>, vol. 62, no. 3. Springer Nature, 2025.","mla":"Hsu, Tzu Han, et al. “Gray-Box Runtime Enforcement of Hyperproperties.” <i>Acta Informatica</i>, vol. 62, no. 3, 30, Springer Nature, 2025, doi:<a href=\"https://doi.org/10.1007/s00236-025-00502-1\">10.1007/s00236-025-00502-1</a>.","chicago":"Hsu, Tzu Han, Ana A Oliveira da Costa, Andrew Wintenberg, Ezio Bartocci, and Borzoo Bonakdarpour. “Gray-Box Runtime Enforcement of Hyperproperties.” <i>Acta Informatica</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/s00236-025-00502-1\">https://doi.org/10.1007/s00236-025-00502-1</a>.","short":"T.H. Hsu, A.A. Oliveira da Costa, A. Wintenberg, E. Bartocci, B. Bonakdarpour, Acta Informatica 62 (2025)."},"OA_type":"hybrid","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","status":"public","_id":"20186","year":"2025","doi":"10.1007/s00236-025-00502-1","quality_controlled":"1","abstract":[{"text":"Enforcement of information-flow policies has been extensively studied by language-based approaches over the past few decades. In this paper, we propose an alternative, novel, general, and effective approach using enforcement of hyperproperties– a powerful formalism for expressing and reasoning about a wide range of information-flow security policies. We study black- vs. gray- vs. white-box enforcement of hyperproperties expressed by nondeterministic finite-word hyperautomata (NFH), where the enforcer has null, some, or complete information about the implementation of the system under scrutiny. Given an NFH, in order to generate a runtime enforcer, we reduce the problem to controller synthesis for hyperproperties and subsequently to the satisfiability problem for quantified Boolean formulas (QBFs). The resulting enforcers are transferable with low-overhead. We conduct a rich set of case studies, including information-flow control for JavaScript code, as well as synthesizing obfuscators for control plants.","lang":"eng"}],"intvolume":"        62","publication_status":"published","author":[{"first_name":"Tzu Han","full_name":"Hsu, Tzu Han","last_name":"Hsu"},{"first_name":"Ana A","last_name":"Oliveira Da Costa","full_name":"Oliveira Da Costa, Ana A","id":"8b282559-50b0-11ef-861e-d6ace0d92e9b"},{"full_name":"Wintenberg, Andrew","last_name":"Wintenberg","first_name":"Andrew"},{"first_name":"Ezio","last_name":"Bartocci","full_name":"Bartocci, Ezio"},{"last_name":"Bonakdarpour","full_name":"Bonakdarpour, Borzoo","first_name":"Borzoo"}],"issue":"3","date_published":"2025-09-01T00:00:00Z","fulldoi":"https://doi.org/10.1007/s00236-025-00502-1","isi":1,"project":[{"_id":"34a1b658-11ca-11ed-8bc3-c75229f0241e","grant_number":"F8502","name":"Interface Theory for Security and Privacy"}],"oa_version":"Published Version","day":"01","oa":1,"title":"Gray-box runtime enforcement of hyperproperties","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2025-09-30T14:20:11Z","publication_identifier":{"eissn":["1432-0525"],"issn":["0001-5903"]},"publisher":"Springer Nature","has_accepted_license":"1","scopus_import":"1","OA_place":"publisher","file_date_updated":"2025-09-02T05:53:47Z","corr_author":"1","file":[{"date_updated":"2025-09-02T05:53:47Z","success":1,"date_created":"2025-09-02T05:53:47Z","access_level":"open_access","file_name":"2025_ActaInformatica_Hsu.pdf","creator":"dernst","content_type":"application/pdf","relation":"main_file","file_id":"20267","file_size":6505049,"checksum":"90a43350fd4a8c5cb5b1b0e1aea7970d"}],"language":[{"iso":"eng"}],"department":[{"_id":"ToHe"}],"volume":62,"acknowledgement":"This project was funded in part by the Austrian Science Fund (FWF) SFB project SpyCoDe F8502, Vienna Science and Technology Fund (WWTF) [10.47379/ICT19018] (ProbInG) and WWTF project ICT22-023 (TAIGER), National Science Foundation (NSF) CPS Award 1837680, NSF award ECCS-2144416 and NSF SaTC Award 2245114. Open access funding provided by Institute of Science and Technology (IST Austria).","article_type":"original","date_created":"2025-08-17T22:01:36Z","ddc":["000"],"month":"09","type":"journal_article"},{"oa":1,"day":"01","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2025-11-27T14:12:24Z","title":"Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration","has_accepted_license":"1","file_date_updated":"2025-09-01T10:02:24Z","OA_place":"publisher","scopus_import":"1","publication_identifier":{"issn":[" 0021-9533"],"eissn":["1477-9137"]},"publisher":"The Company of Biologists","date_created":"2025-08-17T22:01:36Z","pmid":1,"acknowledgement":"We are grateful to the members of the Matsuda Laboratory for their helpful input, to K. Hirano, T. Uesugi and K. Takakura, who provided technical assistance, and to the Medical Research Support Center of Kyoto University for DNA sequence analysis. This work was supported by the Kyoto University Live Imaging Center. Financial support was provided by Japan Society for the Promotion of Science (JSPS) KAKENHI grants (21H05226 to K.T., 19H00993 and 20H05898 to M.M.), a Japan Science and Technology Agency (JST) CREST grant (JPMJCR1654 to M.M.), and a JST Moonshot Research and Development Program grant (JPMJPS2022 to M.M.). Open Access funding provided by Tokushima University. Deposited in PMC for immediate release.","volume":138,"article_type":"original","month":"08","type":"journal_article","ddc":["570"],"file":[{"file_name":"2025_JourCellScience_Jikko.pdf","creator":"dernst","success":1,"date_updated":"2025-09-01T10:02:24Z","date_created":"2025-09-01T10:02:24Z","access_level":"open_access","file_size":12393297,"file_id":"20262","checksum":"29f42619dab5ce251a20c769ed4581c0","content_type":"application/pdf","relation":"main_file"}],"department":[{"_id":"CaHe"}],"language":[{"iso":"eng"}],"PlanS_conform":"1","article_processing_charge":"Yes (via OA deal)","external_id":{"pmid":["40667649"],"isi":["001567723900009"]},"citation":{"ista":"Jikko Y, Deguchi E, Matsuda K, Hino N, Tsukiji S, Matsuda M, Terai K. 2025. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. Journal of Cell Science. 138(15), 263779.","ieee":"Y. Jikko <i>et al.</i>, “Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration,” <i>Journal of Cell Science</i>, vol. 138, no. 15. The Company of Biologists, 2025.","apa":"Jikko, Y., Deguchi, E., Matsuda, K., Hino, N., Tsukiji, S., Matsuda, M., &#38; Terai, K. (2025). Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. <i>Journal of Cell Science</i>. The Company of Biologists. <a href=\"https://doi.org/10.1242/jcs.263779\">https://doi.org/10.1242/jcs.263779</a>","short":"Y. Jikko, E. Deguchi, K. Matsuda, N. Hino, S. Tsukiji, M. Matsuda, K. Terai, Journal of Cell Science 138 (2025).","mla":"Jikko, Yuya, et al. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” <i>Journal of Cell Science</i>, vol. 138, no. 15, 263779, The Company of Biologists, 2025, doi:<a href=\"https://doi.org/10.1242/jcs.263779\">10.1242/jcs.263779</a>.","chicago":"Jikko, Yuya, Eriko Deguchi, Kimiya Matsuda, Naoya Hino, Shinya Tsukiji, Michiyuki Matsuda, and Kenta Terai. “Front-Biased Activation of the Ras-Rab5-Rac1 Loop Coordinates Collective Cell Migration.” <i>Journal of Cell Science</i>. The Company of Biologists, 2025. <a href=\"https://doi.org/10.1242/jcs.263779\">https://doi.org/10.1242/jcs.263779</a>.","ama":"Jikko Y, Deguchi E, Matsuda K, et al. Front-biased activation of the Ras-Rab5-Rac1 loop coordinates collective cell migration. <i>Journal of Cell Science</i>. 2025;138(15). doi:<a href=\"https://doi.org/10.1242/jcs.263779\">10.1242/jcs.263779</a>"},"article_number":"263779","publication":"Journal of Cell Science","year":"2025","OA_type":"hybrid","_id":"20188","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","quality_controlled":"1","doi":"10.1242/jcs.263779","fulldoi":"https://doi.org/10.1242/jcs.263779","date_published":"2025-08-01T00:00:00Z","isi":1,"oa_version":"Published Version","abstract":[{"text":"Collective cell migration is coordinated by the front-to-rear intercellular propagation of EGFR-Ras-ERK pathway activation. However, the molecular mechanisms integrating front-to-rear information into this intercellular signaling cascade, particularly the determinants of cellular front-side specification, remain elusive. We visualized the activity of EGFR, Ras, Rac1 and Rab5A (hereafter Rab5) by using FRET biosensors and chemogenetic tools. Whereas EGFR activation was uniformly observed within cells, Ras activation was biased to the front side within cells. The polarized Ras activation depended on Merlin and Rac1, which also showed front-biased activation. Furthermore, Rab5, a crucial regulator of cell migration, demonstrated similar front-biased activation and was found to function downstream of Ras while being necessary for Rac1 activation. Thus, the positive feedback loop consisting of Ras, Rab5 and Rac1 is activated primarily at the front of collectively migrating cells. These findings offer new spatio-temporal insight into processing front–rear information during collective cell migration.","lang":"eng"}],"intvolume":"       138","publication_status":"published","issue":"15","author":[{"first_name":"Yuya","last_name":"Jikko","full_name":"Jikko, Yuya"},{"full_name":"Deguchi, Eriko","last_name":"Deguchi","first_name":"Eriko"},{"full_name":"Matsuda, Kimiya","last_name":"Matsuda","first_name":"Kimiya"},{"first_name":"Naoya","id":"5299a9ce-7679-11eb-a7bc-d1e62b936307","full_name":"Hino, Naoya","last_name":"Hino"},{"first_name":"Shinya","last_name":"Tsukiji","full_name":"Tsukiji, Shinya"},{"first_name":"Michiyuki","last_name":"Matsuda","full_name":"Matsuda, Michiyuki"},{"full_name":"Terai, Kenta","last_name":"Terai","first_name":"Kenta"}]},{"title":"Introducing certificates to the hardware model checking competition","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2025-12-01T12:34:05Z","day":"01","oa":1,"file":[{"date_updated":"2025-09-02T05:46:10Z","success":1,"access_level":"open_access","date_created":"2025-09-02T05:46:10Z","file_name":"2025_CAV_Froleyks.pdf","creator":"dernst","content_type":"application/pdf","relation":"main_file","file_id":"20266","file_size":1078274,"checksum":"15ec1bc9b9409d3b2736f4c9d5f42fd1"}],"language":[{"iso":"eng"}],"department":[{"_id":"ToHe"}],"acknowledgement":"This work is supported in part by the ERC-2020-AdG 101020093, the LIT AI Lab funded by the State of Upper Austria, the Research Council of Finland under the project 336092, and a gift from Intel Corporation.\r\nFurthermore we of course also owe a big thank-you to the submitters of model checkers and benchmarks to the competition over all these years. Without their enthusiasm and support neither the competition nor this study would exist.","volume":15931,"date_created":"2025-08-17T22:01:36Z","page":"281-295","month":"01","ddc":["000"],"type":"conference","publication_identifier":{"isbn":["9783031986673"],"issn":["0302-9743"],"eissn":["1611-3349"]},"ec_funded":1,"publisher":"Springer Nature","has_accepted_license":"1","alternative_title":["LNCS"],"scopus_import":"1","file_date_updated":"2025-09-02T05:46:10Z","OA_place":"publisher","OA_type":"hybrid","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"20189","year":"2025","publication":"37th International Conference on Computer Aided Verification","external_id":{"isi":["001562507100014"]},"article_processing_charge":"Yes (in subscription journal)","citation":{"ista":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. 2025. Introducing certificates to the hardware model checking competition. 37th International Conference on Computer Aided Verification. CAV: Computer Aided Verification, LNCS, vol. 15931, 281–295.","ieee":"N. Froleyks, E. Yu, M. Preiner, A. Biere, and K. Heljanko, “Introducing certificates to the hardware model checking competition,” in <i>37th International Conference on Computer Aided Verification</i>, Zagreb, Croatia, 2025, vol. 15931, pp. 281–295.","apa":"Froleyks, N., Yu, E., Preiner, M., Biere, A., &#38; Heljanko, K. (2025). Introducing certificates to the hardware model checking competition. In <i>37th International Conference on Computer Aided Verification</i> (Vol. 15931, pp. 281–295). Zagreb, Croatia: Springer Nature. <a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">https://doi.org/10.1007/978-3-031-98668-0_14</a>","short":"N. Froleyks, E. Yu, M. Preiner, A. Biere, K. Heljanko, in:, 37th International Conference on Computer Aided Verification, Springer Nature, 2025, pp. 281–295.","mla":"Froleyks, Nils, et al. “Introducing Certificates to the Hardware Model Checking Competition.” <i>37th International Conference on Computer Aided Verification</i>, vol. 15931, Springer Nature, 2025, pp. 281–95, doi:<a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">10.1007/978-3-031-98668-0_14</a>.","chicago":"Froleyks, Nils, Emily Yu, Mathias Preiner, Armin Biere, and Keijo Heljanko. “Introducing Certificates to the Hardware Model Checking Competition.” In <i>37th International Conference on Computer Aided Verification</i>, 15931:281–95. Springer Nature, 2025. <a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">https://doi.org/10.1007/978-3-031-98668-0_14</a>.","ama":"Froleyks N, Yu E, Preiner M, Biere A, Heljanko K. Introducing certificates to the hardware model checking competition. In: <i>37th International Conference on Computer Aided Verification</i>. Vol 15931. Springer Nature; 2025:281-295. doi:<a href=\"https://doi.org/10.1007/978-3-031-98668-0_14\">10.1007/978-3-031-98668-0_14</a>"},"intvolume":"     15931","abstract":[{"lang":"eng","text":"Certification was made mandatory for the first time in the latest hardware model checking competition. In this case study, we investigate the trade-offs of requiring certificates for both passing and failing properties in the competition. Our evaluation shows that participating model checkers were able to produce compact, correct certificates that could be verified with minimal overhead. Furthermore, the certifying winner of the competition outperforms the previous non-certifying state-of-the-art model checker, demonstrating that certification can be adopted without compromising model checking efficiency."}],"publication_status":"published","author":[{"last_name":"Froleyks","full_name":"Froleyks, Nils","first_name":"Nils"},{"orcid":"0000-0002-4993-773X","first_name":"Zhengqi","full_name":"Yu, Zhengqi","id":"20aa2ae8-f2f1-11ed-bbfa-8205053f1342","last_name":"Yu"},{"last_name":"Preiner","full_name":"Preiner, Mathias","first_name":"Mathias"},{"last_name":"Biere","full_name":"Biere, Armin","first_name":"Armin"},{"first_name":"Keijo","last_name":"Heljanko","full_name":"Heljanko, Keijo"}],"fulldoi":"https://doi.org/10.1007/978-3-031-98668-0_14","oa_version":"Published Version","date_published":"2025-01-01T00:00:00Z","isi":1,"project":[{"call_identifier":"H2020","_id":"62781420-2b32-11ec-9570-8d9b63373d4d","grant_number":"101020093","name":"Vigilant Algorithmic Monitoring of Software"}],"conference":{"location":"Zagreb, Croatia","name":"CAV: Computer Aided Verification","start_date":"2025-07-23","end_date":"2025-07-25"},"doi":"10.1007/978-3-031-98668-0_14","quality_controlled":"1"},{"year":"2025","OA_type":"diamond","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","_id":"20192","external_id":{"arxiv":["2408.03189"]},"article_processing_charge":"No","PlanS_conform":"1","citation":{"apa":"Katz, H., Cameron, A. J., Saxena, A., Barrufet, L., Choustikov, N., Cleri, N. J., … Oesch, P. A. (2025). 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing. <a href=\"https://doi.org/10.33232/001c.142570\">https://doi.org/10.33232/001c.142570</a>","ieee":"H. Katz <i>et al.</i>, “21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations,” <i>The Open Journal of Astrophysics</i>, vol. 8. Maynooth Academic Publishing, 2025.","ista":"Katz H, Cameron AJ, Saxena A, Barrufet L, Choustikov N, Cleri NJ, De Graaff A, Ellis RS, Fosbury RAE, Heintz KE, Maseda M, Matthee JJ, Mcconachie I, Oesch PA. 2025. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. The Open Journal of Astrophysics. 8.","short":"H. Katz, A.J. Cameron, A. Saxena, L. Barrufet, N. Choustikov, N.J. Cleri, A. De Graaff, R.S. Ellis, R.A.E. Fosbury, K.E. Heintz, M. Maseda, J.J. Matthee, I. Mcconachie, P.A. Oesch, The Open Journal of Astrophysics 8 (2025).","chicago":"Katz, Harley, Alex J. Cameron, Aayush Saxena, Laia Barrufet, Nicholas Choustikov, Nikko J. Cleri, Anna De Graaff, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” <i>The Open Journal of Astrophysics</i>. Maynooth Academic Publishing, 2025. <a href=\"https://doi.org/10.33232/001c.142570\">https://doi.org/10.33232/001c.142570</a>.","mla":"Katz, Harley, et al. “21 Balmer Jump Street: The Nebular Continuum at High Redshift and Implications for the Bright Galaxy Problem, UV Continuum Slopes, and Early Stellar Populations.” <i>The Open Journal of Astrophysics</i>, vol. 8, Maynooth Academic Publishing, 2025, doi:<a href=\"https://doi.org/10.33232/001c.142570\">10.33232/001c.142570</a>.","ama":"Katz H, Cameron AJ, Saxena A, et al. 21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations. <i>The Open Journal of Astrophysics</i>. 2025;8. doi:<a href=\"https://doi.org/10.33232/001c.142570\">10.33232/001c.142570</a>"},"publication":"The Open Journal of Astrophysics","fulldoi":"https://doi.org/10.33232/001c.142570","date_published":"2025-07-25T00:00:00Z","oa_version":"Published Version","abstract":[{"text":"We study the physical origin and spectroscopic impact of extreme nebular emission in high-redshift galaxies. The nebular continuum, which can appear during an extreme starburst, is of particular importance as it tends to redden UV slopes and has a significant contribution to the UV luminosities of galaxies. Furthermore, its shape can be used to infer the gas density and temperature of the interstellar medium. First, we provide a theoretical background, showing how different stellar populations (SPS models, initial mass functions (IMFs), and stellar temperatures) and nebular conditions impact observed galaxy spectra. We demonstrate that, for systems with strong nebular continuum emission, 1) UV fluxes can increase by up to 0.7~mag (or more in the case of hot/massive stars) above the stellar continuum, which may help reconcile the surprising abundance of bright high-redshift galaxies and the elevated UV luminosity density at z>10, 2) at high gas densities, UV slopes can redden from \\beta<-2.5 to \\beta\\sim-1, 3) observational measurements of \\xi_{\\rm ion} are gross underestimates, and 4) UV downturns from two-photon emission can masquerade as damped Ly\\alpha systems. Second, we present a dataset of 58 galaxies observed with NIRSpec on JWST at 2.5<z<9.0 that are selected to have strong nebular continuum emission via the detection of the Balmer jump. Five of the 58 spectra are consistent with being dominated by nebular emission, exhibiting both a Balmer jump and a UV downturn consistent with two-photon emission. For some galaxies, this may imply the presence of hot massive stars and a top-heavy IMF. We conclude by exploring the properties of spectroscopically confirmed z>10 galaxies, finding that UV slopes and UV downturns are in some cases redder or steeper than expected from SPS models, which may hint at more exotic (e.g. hotter/more massive stars or AGN) ionizing sources.","lang":"eng"}],"intvolume":"         8","publication_status":"published","author":[{"last_name":"Katz","full_name":"Katz, Harley","first_name":"Harley"},{"full_name":"Cameron, Alex J.","last_name":"Cameron","first_name":"Alex J."},{"full_name":"Saxena, Aayush","last_name":"Saxena","first_name":"Aayush"},{"first_name":"Laia","full_name":"Barrufet, Laia","last_name":"Barrufet"},{"first_name":"Nicholas","last_name":"Choustikov","full_name":"Choustikov, Nicholas"},{"full_name":"Cleri, Nikko J.","last_name":"Cleri","first_name":"Nikko J."},{"full_name":"De Graaff, Anna","last_name":"De Graaff","first_name":"Anna"},{"first_name":"Richard S.","last_name":"Ellis","full_name":"Ellis, Richard S."},{"first_name":"Robert A.E.","full_name":"Fosbury, Robert A.E.","last_name":"Fosbury"},{"first_name":"Kasper E.","full_name":"Heintz, Kasper E.","last_name":"Heintz"},{"first_name":"Michael","last_name":"Maseda","full_name":"Maseda, Michael"},{"first_name":"Jorryt J","orcid":"0000-0003-2871-127X","last_name":"Matthee","full_name":"Matthee, Jorryt J","id":"7439a258-f3c0-11ec-9501-9df22fe06720"},{"last_name":"Mcconachie","full_name":"Mcconachie, Ian","first_name":"Ian"},{"full_name":"Oesch, Pascal A.","last_name":"Oesch","first_name":"Pascal A."}],"doi":"10.33232/001c.142570","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_updated":"2025-09-30T14:29:33Z","title":"21 Balmer Jump Street: The nebular continuum at high redshift and implications for the bright galaxy problem, UV continuum slopes, and early stellar populations","oa":1,"day":"25","article_type":"original","acknowledgement":"HK thanks Andrey Kravtsov for insightful comments and thoughtful discussions. We sincerely thank the PIs and Co-Is of the JWST programs where spectral data was made publicly available on the DJA. We refer interested readers to the following papers for survey descriptions regarding the spectral data: Bunker et al. (2023a); D’Eugenio et al. (2024); Bezanson et al. (2022); Barrufet et al. (2024); de Graaff et al. (2024); Finkelstein et al. (2024); Glazebrook et al. (2024); Pierel et al. (2024); Siebert et al. (2024); Maseda et al. (2024). This work is based in part on observations made with the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with programs listed in Table 1. AJC and AS acknowledge funding from the “FirstGalaxies” Advanced Grant from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant agreement No. 789056). ","volume":8,"date_created":"2025-08-17T22:01:37Z","type":"journal_article","month":"07","ddc":["520"],"file":[{"date_updated":"2025-09-30T14:28:25Z","success":1,"access_level":"open_access","date_created":"2025-09-30T14:28:25Z","file_name":"2025_OpenJourAstrophysics_Katz.pdf","creator":"dernst","content_type":"application/pdf","relation":"main_file","file_size":1836432,"file_id":"20412","checksum":"ba469d132907147f9e86d87f9124dd14"}],"language":[{"iso":"eng"}],"arxiv":1,"department":[{"_id":"JoMa"}],"has_accepted_license":"1","scopus_import":"1","OA_place":"publisher","file_date_updated":"2025-09-30T14:28:25Z","publication_identifier":{"eissn":["2565-6120"]},"publisher":"Maynooth Academic Publishing"},{"day":"01","oa":1,"title":"A post-starburst pathway for the formation of massive galaxies and black holes at z > 6","date_updated":"2025-12-30T13:08:12Z","publisher":"Springer Nature","publication_identifier":{"eissn":["2397-3366"]},"scopus_import":"1","OA_place":"repository","department":[{"_id":"ZoHa"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2409.07113"}],"arxiv":1,"language":[{"iso":"eng"}],"month":"10","type":"journal_article","page":"1541-1552","date_created":"2025-08-17T22:01:38Z","article_type":"original","acknowledgement":"We thank A. C. Carnall for supporting our use of Bagpipes. We thank Y. Fu for his help on the use of QSOFitMORE. We thank J. Greene, S. Toft, T. Kakimoto and M. Tanaka for fruitful discussions. This work is based on observations made with the NASA/ESA/CSA JWST. The data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, under NASA contract NAS 5-03127 for JWST. These observations are associated with programmes GO 1967 and GO 3859. Support for these programmes was provided by NASA through a grant from the Space Telescope Science Institute. This work was supported by World Premier International Research Center Initiative, MEXT, Japan. This work used computing resources at Kavli IPMU. M.O., X.D., J.D.S., Y.M., T.I., K. Ito, K.K. and H.U. are supported by the Japan Society for the Promotion of Science (KAKENHI Grant Numbers JP24K22894, JP22K14071, JP18H01251, JP22H01262, JP21H04494, JP20K14531, JP23K13141, JP17H06130 and JP20H01953). M.O. and K. Inayoshi acknowledge support from the National Natural Science Foundation of China (Grant Numbers 12150410307, 12073003, 11721303, 11991052 and 11950410493). K. Inayoshi acknowledges support from the China Manned Space Project (Grant Numbers CMS-CSST-2021-A04 and CMS-CSST-2021-A06). S.E.I.B. is funded by the Deutsche Forschungsgemeinschaft (German Research Foundation) under Emmy Noether Grant Number BO 5771/1-1. Z.H., T.T. and M.S. acknowledge support from the NSF (Grant Numbers AST-2006176, AST-1907208 and AST-2006177). A.L. acknowledges funding from MUR (Grant Number PRIN 2022935STW). B.T. acknowledges support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (Grant Agreement Number 950533) and from the Israel Science Foundation (Grant Number 1849/19). F. Walter acknowledges support from the ERC (Grant Cosmic_gas). J.-T.S. is supported by the Deutsche Forschungsgemeinschaft (Project Number 518006966). M.T. acknowledges support from the NWO (Grant Number 0.16.VIDI.189.162, ODIN). S.F. acknowledges support from NASA through the NASA Hubble Fellowship (Grant Number HST-HF2-51505.001-A awarded by the Space Telescope Science Institute). K. Iwasawa acknowledges support under Grant Number PID2022-136827NB-C44 funded by MCIN/AEI/10.13039/501100011033 /FEDER, EU. M. Vestergaard gratefully acknowledges financial support from the Independent Research Fund Denmark (Grant Numbers DFF 8021-00130 and 3103-00146). F. Wang acknowledges support from the NSF (Award Number AST-2513040). R.B. is supported by the SNSF through the Ambizione Grant PZ00P2_223532.","volume":9,"publication":"Nature Astronomy","citation":{"mla":"Onoue, Masafusa, et al. “A Post-Starburst Pathway for the Formation of Massive Galaxies and Black Holes at z &#62; 6.” <i>Nature Astronomy</i>, vol. 9, Springer Nature, 2025, pp. 1541–52, doi:<a href=\"https://doi.org/10.1038/s41550-025-02628-1\">10.1038/s41550-025-02628-1</a>.","chicago":"Onoue, Masafusa, Xuheng Ding, John D. Silverman, Yoshiki Matsuoka, Takuma Izumi, Michael A. Strauss, Charlotte Ward, et al. “A Post-Starburst Pathway for the Formation of Massive Galaxies and Black Holes at z &#62; 6.” <i>Nature Astronomy</i>. Springer Nature, 2025. <a href=\"https://doi.org/10.1038/s41550-025-02628-1\">https://doi.org/10.1038/s41550-025-02628-1</a>.","short":"M. Onoue, X. Ding, J.D. Silverman, Y. Matsuoka, T. Izumi, M.A. Strauss, C. Ward, C.L. Phillips, K. Ito, I.T. Andika, K. Aoki, J. Arita, S. Baba, R. Bieri, S.E.I. Bosman, A.C. Eilers, S. Fujimoto, M. Habouzit, Z. Haiman, M. Imanishi, K. Inayoshi, K. Iwasawa, K. Jahnke, N. Kashikawa, T. Kawaguchi, K. Kohno, C.H. Lee, J. Li, A. Lupi, J. Lyu, T. Nagao, R. Overzier, J.T. Schindler, M. Schramm, M.T. Scoggins, K. Shimasaku, Y. Toba, B. Trakhtenbrot, M. Trebitsch, T. Treu, H. Umehata, B. Venemans, M. Vestergaard, M. Volonteri, F. Walter, F. Wang, J. Yang, H. Zhang, Nature Astronomy 9 (2025) 1541–1552.","apa":"Onoue, M., Ding, X., Silverman, J. D., Matsuoka, Y., Izumi, T., Strauss, M. A., … Zhang, H. (2025). A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6. <i>Nature Astronomy</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41550-025-02628-1\">https://doi.org/10.1038/s41550-025-02628-1</a>","ieee":"M. Onoue <i>et al.</i>, “A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6,” <i>Nature Astronomy</i>, vol. 9. Springer Nature, pp. 1541–1552, 2025.","ista":"Onoue M, Ding X, Silverman JD, Matsuoka Y, Izumi T, Strauss MA, Ward C, Phillips CL, Ito K, Andika IT, Aoki K, Arita J, Baba S, Bieri R, Bosman SEI, Eilers AC, Fujimoto S, Habouzit M, Haiman Z, Imanishi M, Inayoshi K, Iwasawa K, Jahnke K, Kashikawa N, Kawaguchi T, Kohno K, Lee CH, Li J, Lupi A, Lyu J, Nagao T, Overzier R, Schindler JT, Schramm M, Scoggins MT, Shimasaku K, Toba Y, Trakhtenbrot B, Trebitsch M, Treu T, Umehata H, Venemans B, Vestergaard M, Volonteri M, Walter F, Wang F, Yang J, Zhang H. 2025. A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6. Nature Astronomy. 9, 1541–1552.","ama":"Onoue M, Ding X, Silverman JD, et al. A post-starburst pathway for the formation of massive galaxies and black holes at z &#62; 6. <i>Nature Astronomy</i>. 2025;9:1541-1552. doi:<a href=\"https://doi.org/10.1038/s41550-025-02628-1\">10.1038/s41550-025-02628-1</a>"},"article_processing_charge":"No","external_id":{"arxiv":["2409.07113"],"isi":["001548138600001"]},"_id":"20193","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","OA_type":"green","year":"2025","quality_controlled":"1","doi":"10.1038/s41550-025-02628-1","publication_status":"published","author":[{"full_name":"Onoue, Masafusa","last_name":"Onoue","first_name":"Masafusa"},{"full_name":"Ding, Xuheng","last_name":"Ding","first_name":"Xuheng"},{"last_name":"Silverman","full_name":"Silverman, John D.","first_name":"John D."},{"last_name":"Matsuoka","full_name":"Matsuoka, Yoshiki","first_name":"Yoshiki"},{"full_name":"Izumi, Takuma","last_name":"Izumi","first_name":"Takuma"},{"first_name":"Michael A.","last_name":"Strauss","full_name":"Strauss, Michael A."},{"first_name":"Charlotte","full_name":"Ward, Charlotte","last_name":"Ward"},{"full_name":"Phillips, Camryn L.","last_name":"Phillips","first_name":"Camryn L."},{"first_name":"Kei","last_name":"Ito","full_name":"Ito, Kei"},{"last_name":"Andika","full_name":"Andika, Irham T.","first_name":"Irham T."},{"first_name":"Kentaro","full_name":"Aoki, Kentaro","last_name":"Aoki"},{"first_name":"Junya","last_name":"Arita","full_name":"Arita, Junya"},{"first_name":"Shunsuke","full_name":"Baba, Shunsuke","last_name":"Baba"},{"last_name":"Bieri","full_name":"Bieri, Rebekka","first_name":"Rebekka"},{"first_name":"Sarah E.I.","last_name":"Bosman","full_name":"Bosman, Sarah E.I."},{"first_name":"Anna Christina","full_name":"Eilers, Anna Christina","last_name":"Eilers"},{"first_name":"Seiji","full_name":"Fujimoto, Seiji","last_name":"Fujimoto"},{"full_name":"Habouzit, Melanie","last_name":"Habouzit","first_name":"Melanie"},{"first_name":"Zoltán","orcid":"0000-0003-3633-5403","last_name":"Haiman","id":"7c006e8c-cc0d-11ee-8322-cb904ef76f36","full_name":"Haiman, Zoltán"},{"full_name":"Imanishi, Masatoshi","last_name":"Imanishi","first_name":"Masatoshi"},{"first_name":"Kohei","full_name":"Inayoshi, Kohei","last_name":"Inayoshi"},{"last_name":"Iwasawa","full_name":"Iwasawa, Kazushi","first_name":"Kazushi"},{"first_name":"Knud","full_name":"Jahnke, Knud","last_name":"Jahnke"},{"first_name":"Nobunari","full_name":"Kashikawa, Nobunari","last_name":"Kashikawa"},{"first_name":"Toshihiro","last_name":"Kawaguchi","full_name":"Kawaguchi, Toshihiro"},{"first_name":"Kotaro","last_name":"Kohno","full_name":"Kohno, Kotaro"},{"last_name":"Lee","full_name":"Lee, Chien Hsiu","first_name":"Chien Hsiu"},{"first_name":"Junyao","full_name":"Li, Junyao","last_name":"Li"},{"first_name":"Alessandro","full_name":"Lupi, Alessandro","last_name":"Lupi"},{"first_name":"Jianwei","full_name":"Lyu, Jianwei","last_name":"Lyu"},{"full_name":"Nagao, Tohru","last_name":"Nagao","first_name":"Tohru"},{"last_name":"Overzier","full_name":"Overzier, Roderik","first_name":"Roderik"},{"full_name":"Schindler, Jan Torge","last_name":"Schindler","first_name":"Jan Torge"},{"last_name":"Schramm","full_name":"Schramm, Malte","first_name":"Malte"},{"last_name":"Scoggins","full_name":"Scoggins, Matthew T.","first_name":"Matthew T."},{"full_name":"Shimasaku, Kazuhiro","last_name":"Shimasaku","first_name":"Kazuhiro"},{"first_name":"Yoshiki","full_name":"Toba, Yoshiki","last_name":"Toba"},{"first_name":"Benny","full_name":"Trakhtenbrot, Benny","last_name":"Trakhtenbrot"},{"first_name":"Maxime","full_name":"Trebitsch, Maxime","last_name":"Trebitsch"},{"first_name":"Tommaso","last_name":"Treu","full_name":"Treu, Tommaso"},{"first_name":"Hideki","last_name":"Umehata","full_name":"Umehata, Hideki"},{"full_name":"Venemans, Bram","last_name":"Venemans","first_name":"Bram"},{"first_name":"Marianne","full_name":"Vestergaard, Marianne","last_name":"Vestergaard"},{"first_name":"Marta","full_name":"Volonteri, Marta","last_name":"Volonteri"},{"last_name":"Walter","full_name":"Walter, Fabian","first_name":"Fabian"},{"last_name":"Wang","full_name":"Wang, Feige","first_name":"Feige"},{"first_name":"Jinyi","full_name":"Yang, Jinyi","last_name":"Yang"},{"full_name":"Zhang, Haowen","last_name":"Zhang","first_name":"Haowen"}],"intvolume":"         9","abstract":[{"text":"Understanding the rapid formation of supermassive black holes in the early Universe requires insights into stellar mass growth in host galaxies. Here we present NIRSpec rest-frame optical spectra and NIRCam imaging from JWST of two galaxies at z > 6, both hosting moderate-luminosity quasars. These galaxies exhibit Balmer absorption lines, like low-redshift post-starburst galaxies. Our analyses of the medium-resolution spectra and multiband photometry show that the bulk of the stellar mass (log(M*/M☉) ≥ 10.6) formed in starburst episodes at redshift 9 and 7. One of the galaxies shows a clear Balmer break and lacks spatially resolved Hα emission. It falls well below the star-formation main sequence at z = 6, indicating quiescence. The other is transitioning to quiescence; together, these massive galaxies are among the most distant post-starburst systems known. The blueshifted wings of the quasar [O iii] emission lines indicate quasar-driven outflow, which possibly influences star formation. Direct stellar velocity dispersion measurements reveal that one galaxy follows the local black hole mass versus σ* relation whereas the other is overmassive. The existence of massive post-starburst galaxies hosting billion-solar-mass black holes in short-lived quasar phases indicates that supermassive black holes and host galaxies played a principal role in each other’s rapid early formation.","lang":"eng"}],"fulldoi":"https://doi.org/10.1038/s41550-025-02628-1","oa_version":"Preprint","isi":1,"date_published":"2025-10-01T00:00:00Z"}]