---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21485'
abstract:
- lang: eng
text: Insulating oxides are among the most abundant solid materials in the universe1,2,3.
Of the many ways in which they influence natural phenomena, perhaps the most consequential
is their capacity to transfer electrical charge during contact4,5,6,7,8,9,10—which
occurs even between samples of the same oxide—yet the symmetry-breaking parameter
that causes this remains unidentified11,12. Here we show that adventitious carbonaceous
molecules adsorbed from the environment are the symmetry-breaking factor in same-material
oxide contact electrification (CE). We use acoustic levitation to measure charge
exchange between a sphere and a plate composed of identical amorphous silicon
dioxide (SiO2). Although charging polarity is random for co-prepared samples,
we control it with baking or plasma treatment. Observing the charge-exchange relaxation
afterwards, we see dynamics over a timescale of hours and connect this directly
to the presence of adventitious carbon with time-of-flight mass spectrometry,
low-energy ion scattering and infrared spectroscopy. Going further, we confirm
that adventitious carbon can even determine charge exchange among different oxides.
Our results identify the symmetry-breaking parameter that causes insulating oxides
to exchange charge in settings ranging from desert sands4 to volcanic plumes5,6,
while simultaneously highlighting an overlooked factor in CE more broadly.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: ScienComp
- _id: LifeSc
acknowledgement: This project has received support from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement no. 949120) and from the Marie Skłodowska-Curie programme (grant
agreement no. 754411). We acknowledge the state of Lower Austria and the European
Regional Development Fund under grant no. WST3-F-542638/004-2021. N.M. acknowledges
support from grant Fondecyt 1221597. G.G. is a Serra Húnter fellow. This research
was supported by the Scientific Service Units of the Institute of Science and Technology
Austria through resources provided by the Miba Machine Shop, Nanofabrication Facility,
Scientific Computing facility and Lab Support Facility. We thank the Modic group
for the use of the Laue camera, T. Zauner for the photography of the experimental
set-up and R. Möller for insightful discussions. Open access funding provided by
Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Galien M
full_name: Grosjean, Galien M
id: 0C5FDA4A-9CF6-11E9-8939-FF05E6697425
last_name: Grosjean
orcid: 0000-0001-5154-417X
- first_name: Markus
full_name: Ostermann, Markus
last_name: Ostermann
- first_name: Markus
full_name: Sauer, Markus
last_name: Sauer
- first_name: Michael
full_name: Hahn, Michael
last_name: Hahn
- first_name: Christian M.
full_name: Pichler, Christian M.
last_name: Pichler
- first_name: Florian
full_name: Fahrnberger, Florian
last_name: Fahrnberger
- first_name: Felix
full_name: Pertl, Felix
id: 6313aec0-15b2-11ec-abd3-ed67d16139af
last_name: Pertl
orcid: 0000-0003-0463-5794
- first_name: Daniel
full_name: Balazs, Daniel
id: 302BADF6-85FC-11EA-9E3B-B9493DDC885E
last_name: Balazs
orcid: 0000-0001-7597-043X
- first_name: Mason M.
full_name: Link, Mason M.
last_name: Link
- first_name: Seong H.
full_name: Kim, Seong H.
last_name: Kim
- first_name: Devin L.
full_name: Schrader, Devin L.
last_name: Schrader
- first_name: Adriana
full_name: Blanco, Adriana
last_name: Blanco
- first_name: Francisco
full_name: Gracia, Francisco
last_name: Gracia
- first_name: Nicolás
full_name: Mujica, Nicolás
last_name: Mujica
- first_name: Scott R
full_name: Waitukaitis, Scott R
id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
last_name: Waitukaitis
orcid: 0000-0002-2299-3176
citation:
ama: Grosjean GM, Ostermann M, Sauer M, et al. Adventitious carbon breaks symmetry
in oxide contact electrification. Nature. 2026;651(8106):626-631. doi:10.1038/s41586-025-10088-w
apa: Grosjean, G. M., Ostermann, M., Sauer, M., Hahn, M., Pichler, C. M., Fahrnberger,
F., … Waitukaitis, S. R. (2026). Adventitious carbon breaks symmetry in oxide
contact electrification. Nature. Springer Nature. https://doi.org/10.1038/s41586-025-10088-w
chicago: Grosjean, Galien M, Markus Ostermann, Markus Sauer, Michael Hahn, Christian
M. Pichler, Florian Fahrnberger, Felix Pertl, et al. “Adventitious Carbon Breaks
Symmetry in Oxide Contact Electrification.” Nature. Springer Nature, 2026.
https://doi.org/10.1038/s41586-025-10088-w.
ieee: G. M. Grosjean et al., “Adventitious carbon breaks symmetry in oxide
contact electrification,” Nature, vol. 651, no. 8106. Springer Nature,
pp. 626–631, 2026.
ista: Grosjean GM, Ostermann M, Sauer M, Hahn M, Pichler CM, Fahrnberger F, Pertl
F, Balazs D, Link MM, Kim SH, Schrader DL, Blanco A, Gracia F, Mujica N, Waitukaitis
SR. 2026. Adventitious carbon breaks symmetry in oxide contact electrification.
Nature. 651(8106), 626–631.
mla: Grosjean, Galien M., et al. “Adventitious Carbon Breaks Symmetry in Oxide Contact
Electrification.” Nature, vol. 651, no. 8106, Springer Nature, 2026, pp.
626–31, doi:10.1038/s41586-025-10088-w.
short: G.M. Grosjean, M. Ostermann, M. Sauer, M. Hahn, C.M. Pichler, F. Fahrnberger,
F. Pertl, D. Balazs, M.M. Link, S.H. Kim, D.L. Schrader, A. Blanco, F. Gracia,
N. Mujica, S.R. Waitukaitis, Nature 651 (2026) 626–631.
corr_author: '1'
date_created: 2026-03-23T15:04:00Z
date_published: 2026-03-18T00:00:00Z
date_updated: 2026-04-28T12:06:01Z
day: '18'
ddc:
- '540'
department:
- _id: ScWa
- _id: GradSch
- _id: LifeSc
doi: 10.1038/s41586-025-10088-w
ec_funded: 1
external_id:
pmid:
- '41851325'
file:
- access_level: open_access
checksum: dafef9ed575b44be4263e948a47ae056
content_type: application/pdf
creator: dernst
date_created: 2026-03-24T06:57:08Z
date_updated: 2026-03-24T06:57:08Z
file_id: '21494'
file_name: 2026_Nature_Grosjean.pdf
file_size: 12245694
relation: main_file
success: 1
file_date_updated: 2026-03-24T06:57:08Z
has_accepted_license: '1'
intvolume: ' 651'
issue: '8106'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '03'
oa: 1
oa_version: Published Version
page: 626-631
pmid: 1
project:
- _id: 0aa60e99-070f-11eb-9043-a6de6bdc3afa
call_identifier: H2020
grant_number: '949120'
name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/colliding-dust-and-the-sparks-of-creation/
status: public
title: Adventitious carbon breaks symmetry in oxide contact electrification
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 651
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21490'
abstract:
- lang: eng
text: Auxin canalization is a self-organizing process that governs the flexible
formation of vasculature by reinforcing the formation of auxin transport channels.
A key prerequisite is the feedback between auxin signaling and directional auxin
transport, mediated by PIN transporters. Despite the developmental importance
of canalization, the molecular components linking auxin perception to the regulation
of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel
and essential component of auxin canalization that links intracellular auxin signaling
with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23
transcriptional auxin signaling. tow mutants exhibit defects in regeneration and
de novo vasculature formation, along with impaired formation of polarized, PIN-expressing
auxin channels. At the subcellular level, these mutants display disrupted auxin-induced
PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes
predominantly to the plasma membrane, where it interacts with receptor-like kinases
involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR
complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at
the cell surface. Together, our findings identify TOW as a molecular link between
intracellular and cell surface auxin signaling mechanisms that converge on PIN
trafficking and polarity, providing new insights into how auxin signaling regulates
directional auxin transport for the self-organizing formation of vasculature during
flexible plant development.
acknowledged_ssus:
- _id: MassSpec
- _id: Bio
- _id: LifeSc
acknowledgement: We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9
system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof.
Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions,
and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also
acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging
& Optics Facility, and the Lab Support Facility at the Institute of Science and
Technology Austria. This research was supported by the Scientific Service Units
(SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF)
and the Lab Support Facility (LSF). The work conducted by the Friml group was funded
by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS)
and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the
core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant
Sciences Core Facility of CEITEC Masaryk University. E.M. received support from
the National Science Centre (NCN), Poland, through the OPUS call within the Weave
programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next
GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes
Amos Comenius.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Mingyue
full_name: Li, Mingyue
id: 01f96916-0235-11eb-9379-a323192643b7
last_name: Li
- first_name: Nikola
full_name: Rydza, Nikola
last_name: Rydza
- first_name: Ewa
full_name: Mazur, Ewa
last_name: Mazur
- first_name: Gergely
full_name: Molnar, Gergely
id: 34F1AF46-F248-11E8-B48F-1D18A9856A87
last_name: Molnar
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization. Current Biology.
2026;36(6):1468-1480.e6. doi:10.1016/j.cub.2026.02.023
apa: Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., & Friml, J. (2026).
Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin
canalization. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2026.02.023
chicago: Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński,
and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters
for Auxin Canalization.” Current Biology. Elsevier, 2026. https://doi.org/10.1016/j.cub.2026.02.023.
ieee: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization,” Current Biology,
vol. 36, no. 6. Elsevier, p. 1468–1480.e6, 2026.
ista: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting
protein TOW stabilizes PIN transporters for auxin canalization. Current Biology.
36(6), 1468–1480.e6.
mla: Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes
PIN Transporters for Auxin Canalization.” Current Biology, vol. 36, no.
6, Elsevier, 2026, p. 1468–1480.e6, doi:10.1016/j.cub.2026.02.023.
short: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology
36 (2026) 1468–1480.e6.
corr_author: '1'
date_created: 2026-03-23T15:11:16Z
date_published: 2026-03-23T00:00:00Z
date_updated: 2026-03-24T08:36:40Z
day: '23'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1016/j.cub.2026.02.023
external_id:
pmid:
- '41831441'
file:
- access_level: open_access
checksum: fe6c41fdab58a55df5f2a5860c02acdc
content_type: application/pdf
creator: dernst
date_created: 2026-03-24T08:34:37Z
date_updated: 2026-03-24T08:34:37Z
file_id: '21496'
file_name: 2026_CurrentBiology_Li.pdf
file_size: 12986894
relation: main_file
success: 1
file_date_updated: 2026-03-24T08:34:37Z
has_accepted_license: '1'
intvolume: ' 36'
issue: '6'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 1468-1480.e6
pmid: 1
project:
- _id: 8f347782-16d5-11f0-9cad-8c19706ee739
grant_number: '101142681'
name: Cyclic nucleotides as second messengers in plants
- _id: bd906599-d553-11ed-ba76-abf8547645d7
grant_number: E271
name: Identification of a novel regulator in auxin canalization
publication: Current Biology
publication_identifier:
issn:
- 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for
auxin canalization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21501'
abstract:
- lang: eng
text: "Kinetically constrained models were originally introduced to capture slow
relaxation in glassy systems, where dynamics are hindered by local constraints
instead of energy barriers. Their quantum counterparts have recently drawn attention
for exhibiting highly degenerate eigenstates at zero energy—known as zero modes—stemming
from chiral symmetry. Yet, the structure and implications of these zero modes
remain poorly understood. In this work, we focus on the properties of the zero
mode subspace in quantum kinetically constrained models with a U(1) particle-conservation
symmetry. We use the U(1) East, which lacks inversion symmetry, and the inversion-symmetric
U(1) East-West models to illustrate our two main results. First, we observe that
the simultaneous presence of constraints and chiral symmetry generally leads to
a parametric increase in the number of zero modes due to the fragmentation of
the many-body\r\nHilbert space into disconnected sectors. Second, we generalize
the concept of compact localized states from single-particle physics and introduce
the notion of collective bound states, a special kind of nonergodic eigenstates
that are robust to enlarging the system size. We formulate sufficient criteria
for their existence, arguing that the degenerate zero mode subspace plays a central
role, and demonstrate bound states in both example models and in a two-dimensional
model, the U(1) North-East, and in the pairflip model, a system without particle
conservation. Our results motivate a systematic study of bound states and their
relation to ergodicity breaking, transport, and other properties of quantum kinetically
constrained\r\nmodels. "
acknowledgement: The authors acknowledge useful discussions with Berislav Buca. This
work was supported by the European Research Council (ERC) under the European Union’s
Horizon 2020 research and innovation program (Grant Agreement No. 850899). M.L.
acknowledges support by the Deutsche Forschungsgemeinschaft (DFG, German Research
Foundation) under Germany’s Excellence Strategy—EXC-2111—390814868. This research
was supported in part by grant NSF PHY-2309135 to the Kavli Institute for Theoretical
Physics (KITP).
article_number: '010352'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Eulalia
full_name: Nicolau Jimenez, Eulalia
id: 04b4791c-8fd7-11ee-a7df-be2fdc569c48
last_name: Nicolau Jimenez
- first_name: Marko
full_name: Ljubotina, Marko
id: F75EE9BE-5C90-11EA-905D-16643DDC885E
last_name: Ljubotina
orcid: 0000-0003-0038-7068
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
citation:
ama: Nicolau Jimenez E, Ljubotina M, Serbyn M. Fragmentation, zero modes, and collective
bound states in constrained models. PRX Quantum. 2026;7. doi:10.1103/sl79-1xgb
apa: Nicolau Jimenez, E., Ljubotina, M., & Serbyn, M. (2026). Fragmentation,
zero modes, and collective bound states in constrained models. PRX Quantum.
American Physical Society. https://doi.org/10.1103/sl79-1xgb
chicago: Nicolau Jimenez, Eulalia, Marko Ljubotina, and Maksym Serbyn. “Fragmentation,
Zero Modes, and Collective Bound States in Constrained Models.” PRX Quantum.
American Physical Society, 2026. https://doi.org/10.1103/sl79-1xgb.
ieee: E. Nicolau Jimenez, M. Ljubotina, and M. Serbyn, “Fragmentation, zero modes,
and collective bound states in constrained models,” PRX Quantum, vol. 7.
American Physical Society, 2026.
ista: Nicolau Jimenez E, Ljubotina M, Serbyn M. 2026. Fragmentation, zero modes,
and collective bound states in constrained models. PRX Quantum. 7, 010352.
mla: Nicolau Jimenez, Eulalia, et al. “Fragmentation, Zero Modes, and Collective
Bound States in Constrained Models.” PRX Quantum, vol. 7, 010352, American
Physical Society, 2026, doi:10.1103/sl79-1xgb.
short: E. Nicolau Jimenez, M. Ljubotina, M. Serbyn, PRX Quantum 7 (2026).
corr_author: '1'
date_created: 2026-03-28T14:57:56Z
date_published: 2026-03-13T00:00:00Z
date_updated: 2026-03-30T06:09:28Z
day: '13'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1103/sl79-1xgb
ec_funded: 1
external_id:
arxiv:
- '2504.17627'
file:
- access_level: open_access
checksum: d155ffa9e1a8275702149165f4bf963c
content_type: application/pdf
creator: dernst
date_created: 2026-03-30T06:08:07Z
date_updated: 2026-03-30T06:08:07Z
file_id: '21505'
file_name: 2026_PRXQuantum_Nicolau.pdf
file_size: 1848724
relation: main_file
success: 1
file_date_updated: 2026-03-30T06:08:07Z
has_accepted_license: '1'
intvolume: ' 7'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication: PRX Quantum
publication_identifier:
eissn:
- 2691-3399
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fragmentation, zero modes, and collective bound states in constrained models
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21503'
abstract:
- lang: eng
text: Currently, pharmacogenetics relies on partially annotated star alleles, leaving
novel variants and complex haplotypes uninterpretable. Computational scoring frameworks
could overcome these limitations. Here, we comprehensively evaluated the ability
of existing (CADD, FATHMM-XF, PROVEAN, MutationAssessor, SIFT, PhyloP100, APF,
APF2) and novel (PharmGScore and PharmMLScore) variant effect predictors to assess
pharmacogenetic alleles in multiple scenarios. Altogether we analyzed 541 PharmVar
alleles, high‑throughput CYP2C9 and CYP2C19 mutational maps, and 200 642 UK Biobank
exomes linked with health records containing antidepressant treatment outcomes.
Many evaluated tools, especially ensemble frameworks, matched or exceeded star
allele classifications (ROC‑AUC up to 0.85 for allele definitions, 0.95 in vitro;
TPR up to 0.99 for exomes) and accurately predicted severe antidepressant adverse
events for carriers of deleterious variants in CYP2C19 (OR 1.20–1.35). Our findings
show that computational predictors deliver star allele accuracy while overcoming
their limitations. With additional validation, computational tools could enhance
clinical decision frameworks by enabling continuous scoring, incorporating previously
unknown variants, and providing genome-wide applicability.
acknowledgement: "This research has been conducted using the UK Biobank Resource under
Application Number 62979. We are grateful to the UK Biobank and all its voluntary
participants. This work used data provided by patients and collected by the NHS
as part of their care and support.\r\n\r\nThis study was funded by the National
Science Center, Poland: PRELUDIUM BIS-3 grant no. 2021/43/O/NZ7/01187 (development
and benchmarking of variant scores) and SONATINA 5 grant 2021/40/C/NZ2/00218 (UKB
analyses). Additional support came from the statutory funds of the Maj Institute
of Pharmacology PAS. We gratefully acknowledge Poland’s high-performance Infrastructure
PLGrid ACK Cyfronet AGH, for providing computer facilities and support within computational
grant no PLG/2022/015861. DMF and GEB were funded by NIH grants NIH R35GM152106
and UM1HG011969."
article_number: '8'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jacek
full_name: Hajto, Jacek
last_name: Hajto
- first_name: Marcin
full_name: Piechota, Marcin
last_name: Piechota
- first_name: Ilse
full_name: Krätschmer, Ilse
id: 30d4014e-7753-11eb-b44b-db6d61112e73
last_name: Krätschmer
orcid: 0000-0002-5636-9259
- first_name: Paula
full_name: Konowalska, Paula
last_name: Konowalska
- first_name: Gabriel E.
full_name: Boyle, Gabriel E.
last_name: Boyle
- first_name: Douglas M.
full_name: Fowler, Douglas M.
last_name: Fowler
- first_name: Malgorzata
full_name: Borczyk, Malgorzata
last_name: Borczyk
- first_name: Michal
full_name: Korostynski, Michal
last_name: Korostynski
citation:
ama: 'Hajto J, Piechota M, Krätschmer I, et al. Computational variant predictors
for pharmacogenomics: From evaluation of single alleles to assessment of adverse
drug reactions to antidepressants. Pharmacogenomics Journal. 2026;26(2).
doi:10.1038/s41397-026-00399-0'
apa: 'Hajto, J., Piechota, M., Krätschmer, I., Konowalska, P., Boyle, G. E., Fowler,
D. M., … Korostynski, M. (2026). Computational variant predictors for pharmacogenomics:
From evaluation of single alleles to assessment of adverse drug reactions to antidepressants.
Pharmacogenomics Journal. Springer Nature. https://doi.org/10.1038/s41397-026-00399-0'
chicago: 'Hajto, Jacek, Marcin Piechota, Ilse Krätschmer, Paula Konowalska, Gabriel
E. Boyle, Douglas M. Fowler, Malgorzata Borczyk, and Michal Korostynski. “Computational
Variant Predictors for Pharmacogenomics: From Evaluation of Single Alleles to
Assessment of Adverse Drug Reactions to Antidepressants.” Pharmacogenomics
Journal. Springer Nature, 2026. https://doi.org/10.1038/s41397-026-00399-0.'
ieee: 'J. Hajto et al., “Computational variant predictors for pharmacogenomics:
From evaluation of single alleles to assessment of adverse drug reactions to antidepressants,”
Pharmacogenomics Journal, vol. 26, no. 2. Springer Nature, 2026.'
ista: 'Hajto J, Piechota M, Krätschmer I, Konowalska P, Boyle GE, Fowler DM, Borczyk
M, Korostynski M. 2026. Computational variant predictors for pharmacogenomics:
From evaluation of single alleles to assessment of adverse drug reactions to antidepressants.
Pharmacogenomics Journal. 26(2), 8.'
mla: 'Hajto, Jacek, et al. “Computational Variant Predictors for Pharmacogenomics:
From Evaluation of Single Alleles to Assessment of Adverse Drug Reactions to Antidepressants.”
Pharmacogenomics Journal, vol. 26, no. 2, 8, Springer Nature, 2026, doi:10.1038/s41397-026-00399-0.'
short: J. Hajto, M. Piechota, I. Krätschmer, P. Konowalska, G.E. Boyle, D.M. Fowler,
M. Borczyk, M. Korostynski, Pharmacogenomics Journal 26 (2026).
date_created: 2026-03-29T22:07:08Z
date_published: 2026-03-09T00:00:00Z
date_updated: 2026-03-30T07:10:50Z
day: '09'
ddc:
- '570'
department:
- _id: MaRo
doi: 10.1038/s41397-026-00399-0
external_id:
pmid:
- '41803106'
file:
- access_level: open_access
checksum: 2fd3d7e48b779ac24245f6c35449b89a
content_type: application/pdf
creator: dernst
date_created: 2026-03-30T07:04:08Z
date_updated: 2026-03-30T07:04:08Z
file_id: '21506'
file_name: 2026_PharmacogenomicsJour_Hajto.pdf
file_size: 2618963
relation: main_file
success: 1
file_date_updated: 2026-03-30T07:04:08Z
has_accepted_license: '1'
intvolume: ' 26'
issue: '2'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Pharmacogenomics Journal
publication_identifier:
eissn:
- 1473-1150
issn:
- ' 1470-269X'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Computational variant predictors for pharmacogenomics: From evaluation of
single alleles to assessment of adverse drug reactions to antidepressants'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21509'
abstract:
- lang: eng
text: Chromatin remodeling complexes mobilize nucleosomes and promote transcription
factor (TF) binding. Using ensemble and single-molecule assays combined with cryo-electron
microscopy (cryo-EM), we studied the interaction between pioneer TFs OCT4–SOX2
and the human BRG1/BRM-associated factor (BAF) complex on nucleosomes. BAF engages
TF-bound substrates in two orientations, placing OCT4–SOX2 at either the remodeler
ENTRY or EXIT site. At the ENTRY site, OCT4–SOX2 initially coexists with BAF without
structural interference. However, continued DNA translocation is expected to cause
collisions with bound TFs, which can trigger remodeling direction reversals or
may induce TF dissociation. To accommodate TFs at the EXIT site, BAF undergoes
structural rearrangements, and ensemble assays reveal a nucleosome subpopulation
translocating away from TF-binding sites. Moreover, single-molecule experiments
show that nucleosome-bound BAF frequently changes remodeling direction, and we
identify an ADP-bound remodeler conformation as a potential intermediate. Together,
these findings reveal key aspects of the conformational dynamics and remodeling
outcomes underlying BAF processing of TF-bound nucleosomes.
acknowledgement: We thank D. Hess, V. Iesmantavicius, and J. Seebacher (FMI Proteomics
and Protein Analysis Facility) for mass spectrometry support; S. Smallwood, K. Shimada,
D. Klein, and M. Schütz-Stoffregen for technical assistance; J. Côté and C. Lachance
for critical discussions; and members of the Thomä lab for helpful feedback. Support
for this work was provided to N.H.T. by the European Research Council under the
European Union’s Horizon 2020 research program (NucEM, no. 884331), the Novartis
Research Foundation, the Swiss National Science Foundation (SNF 31003A_179541, 310030_214852,
and Sinergia CRSII5_186230), and the Swiss Cancer Research (KFS-4980-02-2020 and
KFS-5933-08-2023). S.D. was supported by the European Research Council (DONUTS,
no. 101092623), the Knut and Alice Wallenberg Foundation (2024.0012), the Cancerfonden
(25 4453 Pj), and the Swedish Research Council (VR 03255). A.K.M. was supported
by a Human Frontier Science Program Long-Term Fellowship, and L.V. was supported
by an EMBO fellowship (ALTF 549-2021).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Joscha
full_name: Weiss, Joscha
last_name: Weiss
- first_name: Luca
full_name: Vecchia, Luca
last_name: Vecchia
- first_name: David
full_name: Domjan, David
last_name: Domjan
- first_name: Simone
full_name: Cavadini, Simone
last_name: Cavadini
- first_name: Anton
full_name: Sabantsev, Anton
last_name: Sabantsev
- first_name: Georg
full_name: Kempf, Georg
last_name: Kempf
- first_name: Ganesh R.
full_name: Pathare, Ganesh R.
last_name: Pathare
- first_name: Klaus
full_name: Brackmann, Klaus
last_name: Brackmann
- first_name: Alicia
full_name: Michael, Alicia
id: 6437c950-2a03-11ee-914d-d6476dd7b75c
last_name: Michael
orcid: 0000-0002-6080-839X
- first_name: Lukas
full_name: Kater, Lukas
last_name: Kater
- first_name: Eric
full_name: Hietter-Pfeiffer, Eric
last_name: Hietter-Pfeiffer
- first_name: Mina
full_name: Haddawi, Mina
last_name: Haddawi
- first_name: Urja P.
full_name: Kuber, Urja P.
last_name: Kuber
- first_name: Sandra
full_name: Mühlhäusser, Sandra
last_name: Mühlhäusser
- first_name: Ralph S.
full_name: Grand, Ralph S.
last_name: Grand
- first_name: Michael B.
full_name: Stadler, Michael B.
last_name: Stadler
- first_name: Sebastian
full_name: Deindl, Sebastian
last_name: Deindl
- first_name: Nicolas H.
full_name: Thomä, Nicolas H.
last_name: Thomä
citation:
ama: Weiss J, Vecchia L, Domjan D, et al. The human BAF chromatin remodeler processes
nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell.
2026;86(4):625-639.e8. doi:10.1016/j.molcel.2026.01.021
apa: Weiss, J., Vecchia, L., Domjan, D., Cavadini, S., Sabantsev, A., Kempf, G.,
… Thomä, N. H. (2026). The human BAF chromatin remodeler processes nucleosomes
bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. Elsevier.
https://doi.org/10.1016/j.molcel.2026.01.021
chicago: Weiss, Joscha, Luca Vecchia, David Domjan, Simone Cavadini, Anton Sabantsev,
Georg Kempf, Ganesh R. Pathare, et al. “The Human BAF Chromatin Remodeler Processes
Nucleosomes Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell.
Elsevier, 2026. https://doi.org/10.1016/j.molcel.2026.01.021.
ieee: J. Weiss et al., “The human BAF chromatin remodeler processes nucleosomes
bound by pioneer transcription factors OCT4–SOX2,” Molecular Cell, vol.
86, no. 4. Elsevier, p. 625–639.e8, 2026.
ista: Weiss J, Vecchia L, Domjan D, Cavadini S, Sabantsev A, Kempf G, Pathare GR,
Brackmann K, Michael AK, Kater L, Hietter-Pfeiffer E, Haddawi M, Kuber UP, Mühlhäusser
S, Grand RS, Stadler MB, Deindl S, Thomä NH. 2026. The human BAF chromatin remodeler
processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular
Cell. 86(4), 625–639.e8.
mla: Weiss, Joscha, et al. “The Human BAF Chromatin Remodeler Processes Nucleosomes
Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell, vol.
86, no. 4, Elsevier, 2026, p. 625–639.e8, doi:10.1016/j.molcel.2026.01.021.
short: J. Weiss, L. Vecchia, D. Domjan, S. Cavadini, A. Sabantsev, G. Kempf, G.R.
Pathare, K. Brackmann, A.K. Michael, L. Kater, E. Hietter-Pfeiffer, M. Haddawi,
U.P. Kuber, S. Mühlhäusser, R.S. Grand, M.B. Stadler, S. Deindl, N.H. Thomä, Molecular
Cell 86 (2026) 625–639.e8.
date_created: 2026-03-30T11:58:48Z
date_published: 2026-02-19T00:00:00Z
date_updated: 2026-03-30T12:09:08Z
day: '19'
ddc:
- '570'
department:
- _id: AlMi
doi: 10.1016/j.molcel.2026.01.021
external_id:
pmid:
- '41679301'
file:
- access_level: open_access
checksum: e16a7315b64a706184b177ea1621523c
content_type: application/pdf
creator: dernst
date_created: 2026-03-30T12:04:38Z
date_updated: 2026-03-30T12:04:38Z
file_id: '21510'
file_name: 2026_MolecularCell_Weiss.pdf
file_size: 9786677
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file_date_updated: 2026-03-30T12:04:38Z
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intvolume: ' 86'
issue: '4'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 625-639.e8
pmid: 1
publication: Molecular Cell
publication_identifier:
issn:
- 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription
factors OCT4–SOX2
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 86
year: '2026'
...
---
OA_place: publisher
_id: '21651'
abstract:
- lang: eng
text: "Blockchains enable distributed consensus in permissionless settings, where
participants\r\nare unknown, dynamically changing, and do not trust each other.
While Bitcoin,\r\nbased on Proof-of-Work (PoW), was the first protocol in this
model, significant\r\nresearch has focused on permissionless protocols using alternative
physical resources,\r\nspecifically Proof-of-Space (PoSpace) and Verifiable Delay
Functions (VDFs). This\r\nthesis investigates the theoretical limits and design
space of longest-chain protocols in\r\nthe fully permissionless and dynamically
available settings using these three resources.\r\nFirst, we address the feasibility
of blockchains relying solely on storage as a resource.\r\nWe prove a fundamental
impossibility result: there exists no secure longest-chain\r\nprotocol based exclusively
on Proof-of-Space in the fully permissionless or dynamically\r\navailable settings.
Further, we quantify the adversarial capabilities required to execute\r\na double-spend
attack. Our result formally justifies the necessity of coupling PoSpace\r\nwith
time-dependent primitives (such as VDFs) or to move to less permissive settings\r\n(quasi-permissionless
or permissioned) to ensure security.\r\nSecond, we generalize Nakamoto-like heaviest
chain consensus to protocols utilizing\r\ncombinations of multiple physical resources.
We analyze chain selection rules governed\r\nby a weight function Γ(S, V,W), which
assigns weight to blocks based on recorded\r\nSpace (S), VDF speed (V ), and Work
(W). We provide a complete classification\r\nof secure weight functions, proving
that a weight function is secure against private\r\ndouble-spend attacks if and
only if it is homogeneous in the timed resources (V,W)\r\nand sub-homogeneous
in S. This framework unifies existing protocols like Bitcoin and\r\nChia under
a single theoretical model and provides a powerful tool for designing new\r\nlongest-chain
blockchains from a mix of physical resources."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Mirza Ahad
full_name: Baig, Mirza Ahad
id: 3EDE6DE4-AA5A-11E9-986D-341CE6697425
last_name: Baig
citation:
ama: Baig MA. On secure chain selection rules from physical resources in a permissionless
setting. 2026. doi:10.15479/AT-ISTA-21651
apa: Baig, M. A. (2026). On secure chain selection rules from physical resources
in a permissionless setting. Institute of Science and Technology Austria.
https://doi.org/10.15479/AT-ISTA-21651
chicago: Baig, Mirza Ahad. “On Secure Chain Selection Rules from Physical Resources
in a Permissionless Setting.” Institute of Science and Technology Austria, 2026.
https://doi.org/10.15479/AT-ISTA-21651.
ieee: M. A. Baig, “On secure chain selection rules from physical resources in a
permissionless setting,” Institute of Science and Technology Austria, 2026.
ista: Baig MA. 2026. On secure chain selection rules from physical resources in
a permissionless setting. Institute of Science and Technology Austria.
mla: Baig, Mirza Ahad. On Secure Chain Selection Rules from Physical Resources
in a Permissionless Setting. Institute of Science and Technology Austria,
2026, doi:10.15479/AT-ISTA-21651.
short: M.A. Baig, On Secure Chain Selection Rules from Physical Resources in a Permissionless
Setting, Institute of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-04-02T09:31:34Z
date_published: 2026-03-04T00:00:00Z
date_updated: 2026-04-15T08:45:19Z
day: '04'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: GradSch
- _id: KrPi
doi: 10.15479/AT-ISTA-21651
file:
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creator: mbaig
date_created: 2026-04-03T17:28:48Z
date_updated: 2026-04-13T08:24:13Z
file_id: '21655'
file_name: PhD-Thesis-Mirza-Ahad-Baig - Library Submission.zip
file_size: 139353434
relation: source_file
- access_level: open_access
checksum: 292a5989262521f7c145a109d1f348cb
content_type: application/pdf
creator: mbaig
date_created: 2026-04-03T17:29:30Z
date_updated: 2026-04-15T07:37:25Z
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file_name: 2026_Baig_Mirza_Ahad_Thesis.pdf
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file_date_updated: 2026-04-15T07:37:25Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '03'
oa: 1
oa_version: Published Version
publication_identifier:
isbn:
- 978-3-99078-078-7
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '21134'
relation: part_of_dissertation
status: public
- id: '20587'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
title: On secure chain selection rules from physical resources in a permissionless
setting
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21657'
abstract:
- lang: eng
text: We compare three global kilometer-scale models (ICON, IFS and NICAM) to clarify
the advantages and challenges of high-resolution global weather and climate modeling,
using different approaches to represent convection, from fully parameterized to
fully explicit. Our analysis focuses on tropical precipitation characteristics
spanning a wide range of spatio-temporal scales—including the diurnal cycle, extreme
precipitation, convective organization, and the Madden-Julian Oscillation (MJO)—along
with interactions between convection and the thermodynamic environment. All three
models commonly show weaker convective organization with smaller precipitation
cells than observed, though the strength of the bias varies by model. This diversity
is introduced by differences in the representation of (a) convective initiation
affected by the convective sensitivity to moisture and (b) tropospheric moistening
associated with deep convection. Models with stronger thermodynamic-convection
coupling increase environmental moisture near convection, thereby enhancing convective
organization. This has important upscale effects on the MJO; while IFS and NICAM
capture its eastward propagation well, ICON has difficulty reproducing it. The
amplitudes and phases of precipitation diurnal cycles over land show much greater
disagreement among the models than over ocean, influenced by how convection is
initiated. Biases in rain evaporation and cold pool formation hinder the propagation
of mesoscale convection, leading to errors such as the misrepresentation of nocturnal
convection moving off the coast of Sumatra in IFS and ICON. These results highlight
the importance of thermodynamic-convection coupling in realistically simulating
tropical convection across scales. To improve this coupling, kilometer-scale models
require better representation of the interaction between resolved convection and
three-dimensional turbulent mixing.
acknowledgement: 'We thank Peter Bechtold, Lukas Brunner, Peter Dueben, Richard Forbes,
Estibaliz Gascon, and Benoit Vanniere for providing insightful comments on the present
study. We also thank Sebastian Milinski, Xabier Pedruzo and Thomas Rackow for their
contributions to setting up IFS-FESOM for nextGEMS. We are also grateful to Dr.
Walter Hannah and an anonymous reviewer for their constructive comments, which improved
the original version of the manuscript. D. Takasuka was supported by JSPS KAKENHI
Grants 20H05728 and 24K22893 and by JSPS Core-to-Core Program, “International Core-to-Core
Project on Global Storm Resolving Analysis” (Grant Number: JPJSCCA20220001). T.
Becker was supported by the Horizon 2020 project nextGEMS under grant agreement
number 101003470. J. Bao acknowledges funding from the European Union''s Horizon
2020 research and innovation programme under the Marie Skłodowska-Curie grant (grant
agreement No 101034413). The ICON and IFS simulations were performed with supercomputing
resources of the German Climate Computing Centre (Deutsches Klimarechenzentrum,
DKRZ) granted by its Scientific Steering Committee (WLA) under project ID 1235.
The NICAM simulation was performed on the supercomputer Fugaku (proposal numbers
hp220132, hp230078, hp230108, hp230278, and hp240267).'
article_number: e2025MS005343
article_processing_charge: Yes
article_type: original
author:
- first_name: Daisuke
full_name: Takasuka, Daisuke
last_name: Takasuka
- first_name: Tobias
full_name: Becker, Tobias
last_name: Becker
- first_name: Jiawei
full_name: Bao, Jiawei
id: bb9a7399-fefd-11ed-be3c-ae648fd1d160
last_name: Bao
citation:
ama: Takasuka D, Becker T, Bao J. Precipitation characteristics and thermodynamic-convection
coupling in global kilometer-scale simulations. Journal of Advances in Modeling
Earth Systems. 2026;18(3). doi:10.1029/2025MS005343
apa: Takasuka, D., Becker, T., & Bao, J. (2026). Precipitation characteristics
and thermodynamic-convection coupling in global kilometer-scale simulations. Journal
of Advances in Modeling Earth Systems. Wiley. https://doi.org/10.1029/2025MS005343
chicago: Takasuka, Daisuke, Tobias Becker, and Jiawei Bao. “Precipitation Characteristics
and Thermodynamic-Convection Coupling in Global Kilometer-Scale Simulations.”
Journal of Advances in Modeling Earth Systems. Wiley, 2026. https://doi.org/10.1029/2025MS005343.
ieee: D. Takasuka, T. Becker, and J. Bao, “Precipitation characteristics and thermodynamic-convection
coupling in global kilometer-scale simulations,” Journal of Advances in Modeling
Earth Systems, vol. 18, no. 3. Wiley, 2026.
ista: Takasuka D, Becker T, Bao J. 2026. Precipitation characteristics and thermodynamic-convection
coupling in global kilometer-scale simulations. Journal of Advances in Modeling
Earth Systems. 18(3), e2025MS005343.
mla: Takasuka, Daisuke, et al. “Precipitation Characteristics and Thermodynamic-Convection
Coupling in Global Kilometer-Scale Simulations.” Journal of Advances in Modeling
Earth Systems, vol. 18, no. 3, e2025MS005343, Wiley, 2026, doi:10.1029/2025MS005343.
short: D. Takasuka, T. Becker, J. Bao, Journal of Advances in Modeling Earth Systems
18 (2026).
corr_author: '1'
date_created: 2026-04-05T22:01:31Z
date_published: 2026-03-01T00:00:00Z
date_updated: 2026-06-16T10:43:35Z
day: '01'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1029/2025MS005343
ec_funded: 1
file:
- access_level: open_access
checksum: ca7dac4bab31348d0640ed22580c6dce
content_type: application/pdf
creator: dernst
date_created: 2026-04-07T09:11:23Z
date_updated: 2026-04-07T09:11:23Z
file_id: '21665'
file_name: 2026_JAMES_Takasuka.pdf
file_size: 3854313
relation: main_file
success: 1
file_date_updated: 2026-04-07T09:11:23Z
has_accepted_license: '1'
intvolume: ' 18'
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Journal of Advances in Modeling Earth Systems
publication_identifier:
eissn:
- 1942-2466
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Precipitation characteristics and thermodynamic-convection coupling in global
kilometer-scale simulations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: diamond
PlanS_conform: '1'
_id: '21659'
abstract:
- lang: eng
text: The recent detection of solar equatorial Rossby waves has renewed interest
in the study of gravito-inertial waves propagating in the convective envelope
of solar-type stars. In particular, the ability of these envelope gravito-inertial
modes to couple with those trapped in the radiative interior could open up new
opportunities for probing the deep-layer dynamics of solar-type stars. The possibility
for such a coupling to occur is particularly favoured among pre-main-sequence
(PMS) solar-type stars. Indeed, due to the contraction of the protostellar object,
they are able to reach high rotation frequencies before nuclear reactions are
ignited and magnetic braking becomes the driving mechanism for their rotational
evolution. In this work, we studied the coupling between the envelope inertial
waves and the radiative interior g modes in PMS stars, focussing on the case of
prograde dipolar modes. We considered the cases of 0.5 M⊙ and 1 M⊙ PMS models,
each with three different scenarios of rotational evolution. We show that for
stars that have formed with a sufficient amount of angular momentum, this coupling
can occur in frequency ranges that are accessible to space-borne photometry, creating
inertial dips in the period spacing pattern. Using an asymptotic analysis, we
characterised the shape of these inertial dips to show that they depend on rotation
and on the stiffness of the convective-radiative interface.
acknowledgement: 'The authors want to thank the anonymous referee for useful comments.
SNB acknowledges support from PLATO ASI-INAF agreement no. 2022-28-HH.0 “PLATO Fase
D”. SNB and AFL acknowledge support from the INAF grant MASTODINT. CP thanks the
Belgian Federal Science Policy Office (BELSPO) for the financial support in the
framework of the PRODEX Program of the European Space Agency (ESA) under contract
number 4000141194. S.M acknowledges support from the CNES GOLF-SOHO and PLATO grants
at CEA/DAp. LB and SM gratefully acknowledge support from the European Research
Council (ERC) under the Horizon Europe programme (LB: Calcifer; Starting Grant agreement
N°101165631; SM: 4D-STAR; Synergy Grant agreement N°101071505). While partially
funded by the European Union, views and opinions expressed are, however, those of
the authors only and do not necessarily reflect those of the European Union or the
European Research Council. Neither the European Union nor the granting authority
can be held responsible for them. The authors acknowledge G. Buldgen, H. Dhouib,
and M.A. Dupret for fruitful discussions.'
article_number: L16
article_processing_charge: No
article_type: letter_editor
arxiv: 1
author:
- first_name: S. N.
full_name: Breton, S. N.
last_name: Breton
- first_name: C.
full_name: Pezzotti, C.
last_name: Pezzotti
- first_name: S.
full_name: Mathis, S.
last_name: Mathis
- first_name: Lisa Annabelle
full_name: Bugnet, Lisa Annabelle
id: d9edb345-f866-11ec-9b37-d119b5234501
last_name: Bugnet
orcid: 0000-0003-0142-4000
- first_name: M. P.
full_name: Di Mauro, M. P.
last_name: Di Mauro
- first_name: J.
full_name: Joergensen, J.
last_name: Joergensen
- first_name: K.
full_name: Zwintz, K.
last_name: Zwintz
- first_name: A. F.
full_name: Lanza, A. F.
last_name: Lanza
citation:
ama: Breton SN, Pezzotti C, Mathis S, et al. Core-envelope coupling of gravito-inertial
waves in pre-main-sequence solar-type stars. Astronomy & Astrophysics.
2026;707. doi:10.1051/0004-6361/202659309
apa: Breton, S. N., Pezzotti, C., Mathis, S., Bugnet, L. A., Di Mauro, M. P., Joergensen,
J., … Lanza, A. F. (2026). Core-envelope coupling of gravito-inertial waves in
pre-main-sequence solar-type stars. Astronomy & Astrophysics. Wiley.
https://doi.org/10.1051/0004-6361/202659309
chicago: Breton, S. N., C. Pezzotti, S. Mathis, Lisa Annabelle Bugnet, M. P. Di
Mauro, J. Joergensen, K. Zwintz, and A. F. Lanza. “Core-Envelope Coupling of Gravito-Inertial
Waves in Pre-Main-Sequence Solar-Type Stars.” Astronomy & Astrophysics.
Wiley, 2026. https://doi.org/10.1051/0004-6361/202659309.
ieee: S. N. Breton et al., “Core-envelope coupling of gravito-inertial waves
in pre-main-sequence solar-type stars,” Astronomy & Astrophysics, vol.
707. Wiley, 2026.
ista: Breton SN, Pezzotti C, Mathis S, Bugnet LA, Di Mauro MP, Joergensen J, Zwintz
K, Lanza AF. 2026. Core-envelope coupling of gravito-inertial waves in pre-main-sequence
solar-type stars. Astronomy & Astrophysics. 707, L16.
mla: Breton, S. N., et al. “Core-Envelope Coupling of Gravito-Inertial Waves in
Pre-Main-Sequence Solar-Type Stars.” Astronomy & Astrophysics, vol.
707, L16, Wiley, 2026, doi:10.1051/0004-6361/202659309.
short: S.N. Breton, C. Pezzotti, S. Mathis, L.A. Bugnet, M.P. Di Mauro, J. Joergensen,
K. Zwintz, A.F. Lanza, Astronomy & Astrophysics 707 (2026).
date_created: 2026-04-05T22:01:32Z
date_published: 2026-03-01T00:00:00Z
date_updated: 2026-04-07T09:23:27Z
day: '01'
ddc:
- '520'
department:
- _id: LiBu
doi: 10.1051/0004-6361/202659309
external_id:
arxiv:
- '2603.01979'
file:
- access_level: open_access
checksum: a7fd798bf450d67d4166fdf54ff2c70c
content_type: application/pdf
creator: dernst
date_created: 2026-04-07T09:20:02Z
date_updated: 2026-04-07T09:20:02Z
file_id: '21666'
file_name: 2026_AstronomyAstrophysics_Breton.pdf
file_size: 1535506
relation: main_file
success: 1
file_date_updated: 2026-04-07T09:20:02Z
has_accepted_license: '1'
intvolume: ' 707'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 914d8549-16d5-11f0-9cad-bbe6324c93a9
grant_number: '101165631'
name: 'Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology'
publication: Astronomy & Astrophysics
publication_identifier:
eissn:
- 1432-0746
issn:
- 0004-6361
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Core-envelope coupling of gravito-inertial waves in pre-main-sequence solar-type
stars
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 707
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21660'
abstract:
- lang: eng
text: Kapitza-Dirac scattering, the diffraction of matter waves from a standing
light field, is widely utilized in ultracold gases, but its behavior in the strongly
interacting regime is an open question. Here, we develop a numerically exact two-body
description of Kapitza-Dirac scattering for two contact-interacting atoms in a
one-dimensional harmonic trap subjected to a pulsed optical lattice, enabling
us to obtain the numerically exact dynamics. We map how interaction strength,
lattice depth, lattice wave number, and pulse duration reshape the diffraction
pattern, leading to an interaction-dependent population redistribution in real
and momentum space. By comparing the exact dynamics to an impulsive sudden-approximation
description, we delineate the parameter regimes where it remains accurate and
those, notably at strong attraction and small lattice wave number, where it fails.
Our results provide a controlled few-body benchmark for interacting Kapitza-Dirac
scattering and quantitative guidance for Kapitza-Dirac-based probes of ultracold
atomic systems.
acknowledgement: We thank Max Hachmann, Andreas Hemmerich, and Yann Kiefer for valuable
discussions. This work has been funded by the Cluster of Excellence “Advanced Imaging
of Matter” of the Deutsche Forschungsgemeinschaft (DFG) - EXC 2056 - Project ID
390715994. G.M.K. has received funding by the Austrian Science Fund (FWF) 10.55776/F1004.
article_number: '013297'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: A.
full_name: Becker, A.
last_name: Becker
- first_name: Georgios
full_name: Koutentakis, Georgios
id: d7b23d3a-9e21-11ec-b482-f76739596b95
last_name: Koutentakis
- first_name: P.
full_name: Schmelcher, P.
last_name: Schmelcher
citation:
ama: Becker A, Koutentakis G, Schmelcher P. Two-body Kapitza-Dirac scattering of
one-dimensional ultracold atoms. Physical Review Research. 2026;8. doi:10.1103/rdsn-stlq
apa: Becker, A., Koutentakis, G., & Schmelcher, P. (2026). Two-body Kapitza-Dirac
scattering of one-dimensional ultracold atoms. Physical Review Research.
American Physical Society. https://doi.org/10.1103/rdsn-stlq
chicago: Becker, A., Georgios Koutentakis, and P. Schmelcher. “Two-Body Kapitza-Dirac
Scattering of One-Dimensional Ultracold Atoms.” Physical Review Research.
American Physical Society, 2026. https://doi.org/10.1103/rdsn-stlq.
ieee: A. Becker, G. Koutentakis, and P. Schmelcher, “Two-body Kapitza-Dirac scattering
of one-dimensional ultracold atoms,” Physical Review Research, vol. 8.
American Physical Society, 2026.
ista: Becker A, Koutentakis G, Schmelcher P. 2026. Two-body Kapitza-Dirac scattering
of one-dimensional ultracold atoms. Physical Review Research. 8, 013297.
mla: Becker, A., et al. “Two-Body Kapitza-Dirac Scattering of One-Dimensional Ultracold
Atoms.” Physical Review Research, vol. 8, 013297, American Physical Society,
2026, doi:10.1103/rdsn-stlq.
short: A. Becker, G. Koutentakis, P. Schmelcher, Physical Review Research 8 (2026).
corr_author: '1'
date_created: 2026-04-05T22:01:32Z
date_published: 2026-03-18T00:00:00Z
date_updated: 2026-04-07T09:37:57Z
day: '18'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1103/rdsn-stlq
external_id:
arxiv:
- '2512.15260'
file:
- access_level: open_access
checksum: 339bff9d13486a8028049404988b9b0b
content_type: application/pdf
creator: dernst
date_created: 2026-04-07T09:34:31Z
date_updated: 2026-04-07T09:34:31Z
file_id: '21667'
file_name: 2026_PhysicalReviewResearch_Becker.pdf
file_size: 2131627
relation: main_file
success: 1
file_date_updated: 2026-04-07T09:34:31Z
has_accepted_license: '1'
intvolume: ' 8'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 7c040762-9f16-11ee-852c-dd79eeee4ab3
grant_number: F100403
name: Coherent Optical Metrology Beyond Electric-Dipole-Allowed Transitions
publication: Physical Review Research
publication_identifier:
issn:
- 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Two-body Kapitza-Dirac scattering of one-dimensional ultracold atoms
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21661'
abstract:
- lang: eng
text: Model checking undiscounted reachability and expected-reward properties on
Markov decision processes (MDPs) are key for the verification of systems that
act under uncertainty. Popular algorithms are policy iteration and variants of
value iteration; in tool competitions, most participants rely on the latter. These
algorithms generally need worst-case exponential time. However, the problem can
equally be formulated as a linear programme, solvable in polynomial time. In this
paper, we give a detailed overview of today’s state-of-the-art algorithms for
MDP model checking with a focus on performance and correctness. We highlight their
fundamental differences, and describe various optimizations and implementation
variants. We experimentally compare floating-point and exact-arithmetic implementations
of all algorithms on three benchmark sets using two probabilistic model checkers.
Our results show that (optimistic) value iteration is a sensible default, but
other algorithms are preferable in specific settings. This paper thereby provides
a guide for MDP verification practitioners—tool builders and users alike.
acknowledgement: "This research was funded by the European Union’s Horizon 2020 research
and innovation programme under Marie Skłodowska-Curie grant agreements 101008233
(MISSION)\r\nand 101034413 (IST-BRIDGE), by the Interreg North Sea project STORM_SAFE,
by a KI-Starter grant from the Ministerium für Kultur und Wissenschaft NRW, by NWO
VENI grant no. 639.021.754, and by NWO VIDI grant VI.Vidi.223.110 (TruSTy). Experiments
were performed with computing resources granted by RWTH Aachen University under
project rwth1632."
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Arnd
full_name: Hartmanns, Arnd
last_name: Hartmanns
- first_name: Sebastian
full_name: Junges, Sebastian
last_name: Junges
- first_name: Tim
full_name: Quatmann, Tim
last_name: Quatmann
- first_name: Maximilian
full_name: Weininger, Maximilian
id: 02ab0197-cc70-11ed-ab61-918e71f56881
last_name: Weininger
orcid: 0000-0002-0163-2152
citation:
ama: Hartmanns A, Junges S, Quatmann T, Weininger M. The revised practitioner’s
guide to MDP model checking algorithms. International Journal on Software Tools
for Technology Transfer. 2026. doi:10.1007/s10009-026-00848-y
apa: Hartmanns, A., Junges, S., Quatmann, T., & Weininger, M. (2026). The revised
practitioner’s guide to MDP model checking algorithms. International Journal
on Software Tools for Technology Transfer. Springer Nature. https://doi.org/10.1007/s10009-026-00848-y
chicago: Hartmanns, Arnd, Sebastian Junges, Tim Quatmann, and Maximilian Weininger.
“The Revised Practitioner’s Guide to MDP Model Checking Algorithms.” International
Journal on Software Tools for Technology Transfer. Springer Nature, 2026.
https://doi.org/10.1007/s10009-026-00848-y.
ieee: A. Hartmanns, S. Junges, T. Quatmann, and M. Weininger, “The revised practitioner’s
guide to MDP model checking algorithms,” International Journal on Software
Tools for Technology Transfer. Springer Nature, 2026.
ista: Hartmanns A, Junges S, Quatmann T, Weininger M. 2026. The revised practitioner’s
guide to MDP model checking algorithms. International Journal on Software Tools
for Technology Transfer.
mla: Hartmanns, Arnd, et al. “The Revised Practitioner’s Guide to MDP Model Checking
Algorithms.” International Journal on Software Tools for Technology Transfer,
Springer Nature, 2026, doi:10.1007/s10009-026-00848-y.
short: A. Hartmanns, S. Junges, T. Quatmann, M. Weininger, International Journal
on Software Tools for Technology Transfer (2026).
date_created: 2026-04-05T22:01:32Z
date_published: 2026-03-09T00:00:00Z
date_updated: 2026-04-07T09:52:54Z
day: '09'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1007/s10009-026-00848-y
ec_funded: 1
has_accepted_license: '1'
keyword:
- Quantitative model checking
- Markov decision process
- Linear programming
- Value iteration
- Policy iteration
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1007/s10009-026-00848-y
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: International Journal on Software Tools for Technology Transfer
publication_identifier:
eissn:
- 1433-2787
issn:
- 1433-2779
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '21668'
relation: software
status: public
scopus_import: '1'
status: public
title: The revised practitioner’s guide to MDP model checking algorithms
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21703'
abstract:
- lang: eng
text: Altermagnetism has recently emerged as a distinct class of collinear antiferromagnets
that break time-reversal symmetry, exhibiting a host of novel properties. Applied
strain has attracted particular attention as a key tuning parameter for altermagnets.
Although several experimental studies have demonstrated the preparation of single-domain
states through a combination of applied strain and magnetic field, the route to
such states remains unclear. Here, we use magneto-optical measurements on single
crystals of MnTe under applied strain to show that, in contrast to previous reports,
strain acts primarily to rotate the Néel vector L continuously. Since the orientation
of L determines the magnetic point group symmetry, this continuous rotation effectively
tunes the symmetry and its associated physical properties. Furthermore, we demonstrate
that built-in strain in free-standing crystals is sufficient to pin L into continuous
textures over millimeter length scales. Together, these results provide guidance
for future device design and open the door to leveraging the Néel vector orientation
as a tunable degree of freedom in spintronic applications.
acknowledgement: "This research was primarily funded by the Quantum Materials (KC2202)
program under the U.S. Department of Energy, Office of Science, Office of Basic
Energy Sciences, Materials Sciences and Engineering Division under Contract No.
DE-AC02-05CH11231, which supported the experimental and theoretical work at the
LBNL and UC Berkeley. N.J.G., R. B. R., and I.I.M.\r\nwere supported by Army Research
Office under Cooperative Agreement Number W911NF- 22-2-0173. H.M.L.N. and V.S. acknowledge
funding through the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation)
through Grant No. TRR288—422213477, Project No. A10. H.M.L.N. acknowledges financial
support from the Max Planck Society. Research in Dresden benefits from the environment
provided by the DFG Cluster of Excellence ctd.qmat (EXC2147, Project ID 390858490)."
article_number: '2604.07653'
article_processing_charge: No
arxiv: 1
author:
- first_name: Alex Liebman-Peláez
full_name: Alex Liebman-Peláez, Alex Liebman-Peláez
last_name: Alex Liebman-Peláez
- first_name: Jon
full_name: Kruppe, Jon
last_name: Kruppe
- first_name: Resham Babu
full_name: Regmi, Resham Babu
last_name: Regmi
- first_name: Nirmal J.
full_name: Ghimire, Nirmal J.
last_name: Ghimire
- first_name: Yue
full_name: Sun, Yue
last_name: Sun
- first_name: Igor I.
full_name: Mazin, Igor I.
last_name: Mazin
- first_name: Hilary M. L.
full_name: Noad, Hilary M. L.
last_name: Noad
- first_name: James
full_name: Analytis, James
last_name: Analytis
- first_name: Veronika
full_name: Sunko, Veronika
id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
last_name: Sunko
orcid: 0000-0003-2724-3523
- first_name: Joseph
full_name: Orenstein, Joseph
last_name: Orenstein
citation:
ama: Alex Liebman-Peláez AL-P, Kruppe J, Regmi RB, et al. Strain continuously rotates
the Néel vector in altermagnetic MnTe. arXiv. doi:10.48550/arXiv.2604.07653
apa: Alex Liebman-Peláez, A. L.-P., Kruppe, J., Regmi, R. B., Ghimire, N. J., Sun,
Y., Mazin, I. I., … Orenstein, J. (n.d.). Strain continuously rotates the Néel
vector in altermagnetic MnTe. arXiv. https://doi.org/10.48550/arXiv.2604.07653
chicago: Alex Liebman-Peláez, Alex Liebman-Peláez, Jon Kruppe, Resham Babu Regmi,
Nirmal J. Ghimire, Yue Sun, Igor I. Mazin, Hilary M. L. Noad, James Analytis,
Veronika Sunko, and Joseph Orenstein. “Strain Continuously Rotates the Néel Vector
in Altermagnetic MnTe.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2604.07653.
ieee: A. L.-P. Alex Liebman-Peláez et al., “Strain continuously rotates the
Néel vector in altermagnetic MnTe,” arXiv. .
ista: Alex Liebman-Peláez AL-P, Kruppe J, Regmi RB, Ghimire NJ, Sun Y, Mazin II,
Noad HML, Analytis J, Sunko V, Orenstein J. Strain continuously rotates the Néel
vector in altermagnetic MnTe. arXiv, 2604.07653.
mla: Alex Liebman-Peláez, Alex Liebman-Peláez, et al. “Strain Continuously Rotates
the Néel Vector in Altermagnetic MnTe.” ArXiv, 2604.07653, doi:10.48550/arXiv.2604.07653.
short: A.L.-P. Alex Liebman-Peláez, J. Kruppe, R.B. Regmi, N.J. Ghimire, Y. Sun,
I.I. Mazin, H.M.L. Noad, J. Analytis, V. Sunko, J. Orenstein, ArXiv (n.d.).
date_created: 2026-04-10T14:17:21Z
date_published: 2026-04-08T00:00:00Z
date_updated: 2026-05-04T06:27:12Z
day: '08'
department:
- _id: VeSu
doi: 10.48550/arXiv.2604.07653
external_id:
arxiv:
- '2604.07653'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2604.07653
month: '04'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
status: public
title: Strain continuously rotates the Néel vector in altermagnetic MnTe
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '21704'
abstract:
- lang: eng
text: How functional protein sequences are distributed in sequence space is fundamentally
important for evolutionary theory and protein design, particularly if a large
diversity of protein functions are hidden in evolutionarily unexplored areas of
the sequence space. However, this question is understudied in part because experimental
and computational studies use extant sequences as a starting point to study sequence
space. Here, we study whether extant sequences are representative of the entire
functional sequence space. Across thousands of protein families from vertebrates
and bacteria we calculate the dimensionality and the volume of sequence space
occupied by extant homologs. We find that the observed dimensionality and volume
of extant sequence space are minuscule, many orders of magnitude smaller than
what we estimated using a model of protein evolution. Simulating sequence evolution
we then quantify the impact of phylogeny, selection, and epistasis on restricting
the evolutionary exploration of sequence space. We find that sequence evolution
from a single common ancestor, or a single point of origin in sequence space,
is by far the largest limiting factor that reduces the dimensionality and volume
of extant sequence space. These results indicate that there are vast areas of
functional sequence space that have not been explored in evolution because of
the excessive restrictions on natural exploration of the protein sequence space
imposed by the point of origin effect. We suggest that protein design methods
that rely on extant sequences may be limited in their ability to discover truly
novel functions.
acknowledgement: We thank Olga Kalinina for feedback on our manuscript, Vsevolod Kuksin
for fruitful discussions and Lev Tsarin for participation in the design of our models.
This work was supported by Japan Science and Technology Agency as part of Adopting
Sustainable Partnerships for Innovative Research Ecosystem, Grant No. JPMJAP24B2
(F.A.K. and L.H.I.), and Fonds Zur Förderung der Wissenschaftlichen Forschung Grant
ESP253-B (O.O.B.)
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Lada H.
full_name: Isakova, Lada H.
last_name: Isakova
- first_name: Elizaveta
full_name: Streltsova, Elizaveta
id: 57a170da-dc96-11ea-b7c8-ab3565071bf7
last_name: Streltsova
- first_name: Olga
full_name: Bochkareva, Olga
id: C4558D3C-6102-11E9-A62E-F418E6697425
last_name: Bochkareva
orcid: 0000-0003-1006-6639
- first_name: Peter K.
full_name: Vlasov, Peter K.
last_name: Vlasov
- first_name: Fyodor
full_name: Kondrashov, Fyodor
id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
last_name: Kondrashov
orcid: 0000-0001-8243-4694
citation:
ama: Isakova LH, Streltsova E, Bochkareva O, Vlasov PK, Kondrashov F. Descent from
a common ancestor restricts exploration of protein sequence space. Proceedings
of the National Academy of Sciences. 2026;123(14):e2532018123. doi:10.1073/pnas.2532018123
apa: Isakova, L. H., Streltsova, E., Bochkareva, O., Vlasov, P. K., & Kondrashov,
F. (2026). Descent from a common ancestor restricts exploration of protein sequence
space. Proceedings of the National Academy of Sciences. National Academy
of Sciences. https://doi.org/10.1073/pnas.2532018123
chicago: Isakova, Lada H., Elizaveta Streltsova, Olga Bochkareva, Peter K. Vlasov,
and Fyodor Kondrashov. “Descent from a Common Ancestor Restricts Exploration of
Protein Sequence Space.” Proceedings of the National Academy of Sciences.
National Academy of Sciences, 2026. https://doi.org/10.1073/pnas.2532018123.
ieee: L. H. Isakova, E. Streltsova, O. Bochkareva, P. K. Vlasov, and F. Kondrashov,
“Descent from a common ancestor restricts exploration of protein sequence space,”
Proceedings of the National Academy of Sciences, vol. 123, no. 14. National
Academy of Sciences, p. e2532018123, 2026.
ista: Isakova LH, Streltsova E, Bochkareva O, Vlasov PK, Kondrashov F. 2026. Descent
from a common ancestor restricts exploration of protein sequence space. Proceedings
of the National Academy of Sciences. 123(14), e2532018123.
mla: Isakova, Lada H., et al. “Descent from a Common Ancestor Restricts Exploration
of Protein Sequence Space.” Proceedings of the National Academy of Sciences,
vol. 123, no. 14, National Academy of Sciences, 2026, p. e2532018123, doi:10.1073/pnas.2532018123.
short: L.H. Isakova, E. Streltsova, O. Bochkareva, P.K. Vlasov, F. Kondrashov, Proceedings
of the National Academy of Sciences 123 (2026) e2532018123.
date_created: 2026-04-12T22:01:47Z
date_published: 2026-04-07T00:00:00Z
date_updated: 2026-05-04T06:57:31Z
day: '07'
ddc:
- '570'
department:
- _id: UlWa
doi: 10.1073/pnas.2532018123
external_id:
pmid:
- '41915737'
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checksum: 11b7a13a359e302498b2367906093a6b
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creator: dernst
date_created: 2026-05-04T06:46:31Z
date_updated: 2026-05-04T06:46:31Z
file_id: '21783'
file_name: 2026_PNAS_Isakova.pdf
file_size: 3355016
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intvolume: ' 123'
issue: '14'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: e2532018123
pmid: 1
publication: Proceedings of the National Academy of Sciences
publication_identifier:
eissn:
- 1091-6490
publication_status: published
publisher: National Academy of Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Descent from a common ancestor restricts exploration of protein sequence space
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 123
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21705'
abstract:
- lang: eng
text: "We report the discovery of ATLAS J101342.5−451656.8 (hereafter ATLAS J1013−4516),
an 8.56 minute orbital-period mass-transferring AM Canum Venaticorum (AM CVn)
binary with a mean Gaia magnitude of G = 19.51, identified via periodic variability
in light curves from the Asteroid Terrestrial-impact Last Alert System (ATLAS)
of Gaia white dwarf candidates. Follow-up with the Large Lenslet Array Magellan
Spectrograph shows a helium-dominated accretion disk, and high-speed ULTRACAM
photometry reveals pronounced primary and secondary eclipses. We construct a decade-long
timing baseline leveraging light curves from the ATLAS and Gaia surveys, as well
as the high-speed imagers ULTRACAM on the New Energy Telescope and proto-Lightspeed
on the Magellan Clay telescope. From this timing baseline, we measure an orbital
period derivative of P 1.60 0.07 10 = ± × 12 s s−1. Interpreted in the context
of stable mass transfer, the magnitude and sign of P indicate that the orbital
evolution is governed by the interplay between gravitationalwave-driven angular-momentum
losses and mass transfer, directly probing the donor’s structural response to
mass loss. We constrain the accretor and donor mass based on stable mass-transfer
arguments assuming angularmomentum loss dominated by gravitational-wave emission,
allowing us to infer the characteristic gravitational\r\nwave strain of the binary
for future space-based GW observatories such as the Laser Interferometer Space
Antenna (LISA). We predict a characteristic strain corresponding to a 4 yr LISA
signal-to-noise ratio ≳10, establishing ATLAS J1013−4516 as a strong prospective
LISA source that will probe long-term orbital evolution in the mass-transferring
regime."
acknowledgement: This work has made use of data from the Asteroid Terrestrial-impact
Last Alert System (ATLAS) project. The Asteroid Terrestrial-impact Last Alert System
(ATLAS) project is primarily funded to search for near-Earth asteroids through NASA
grants NN12AR55G, 80NSSC18K0284, and 80NSSC18K1575; byproducts of the NEO search
include images and catalogs from the survey area. This work was partially funded
by Kepler/K2 grant J1944/80NSSC19K0112 and HST GO-15889 and STFC grants ST/T000198/1
and ST/S006109/1. The ATLAS science products have been made possible through the
contributions of the University of Hawaii Institute for Astronomy, the Queen’s University
Belfast, the Space Telescope Science Institute, the South African Astronomical Observatory,
and the Millennium Institute of Astrophysics (MAS), Chile. VSD and ULTRACAM are
supported by STFC grant ST/Z000033/1. J.G.M. gratefully acknowledges support from
the Heising-Simons Foundation and the Pappalardo family through the MIT Pappalardo
Fellowship in Physics.
article_number: '237'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Emma T.
full_name: Chickles, Emma T.
last_name: Chickles
- first_name: Joheen
full_name: Chakraborty, Joheen
last_name: Chakraborty
- first_name: Kevin B.
full_name: Burdge, Kevin B.
last_name: Burdge
- first_name: Vik S.
full_name: Dhillon, Vik S.
last_name: Dhillon
- first_name: Paul
full_name: Draghis, Paul
last_name: Draghis
- first_name: Kareem
full_name: El-Badry, Kareem
last_name: El-Badry
- first_name: Matthew J.
full_name: Green, Matthew J.
last_name: Green
- first_name: Aaron
full_name: Householder, Aaron
last_name: Householder
- first_name: Sarah
full_name: Hughes, Sarah
last_name: Hughes
- first_name: Christopher
full_name: Layden, Christopher
last_name: Layden
- first_name: Stuart P.
full_name: Littlefair, Stuart P.
last_name: Littlefair
- first_name: James
full_name: Munday, James
last_name: Munday
- first_name: Ingrid
full_name: Pelisoli, Ingrid
last_name: Pelisoli
- first_name: Maya S.
full_name: Redden, Maya S.
last_name: Redden
- first_name: John
full_name: Tonry, John
last_name: Tonry
- first_name: Joannes C
full_name: van Roestel, Joannes C
id: 4d122fc8-6083-11f0-87a5-97d68b860333
last_name: van Roestel
- first_name: Francesco Elio
full_name: Angile, Francesco Elio
last_name: Angile
- first_name: Alex J.
full_name: Brown, Alex J.
last_name: Brown
- first_name: Noel Castro
full_name: Segura, Noel Castro
last_name: Segura
- first_name: Jack
full_name: Dinsmore, Jack
last_name: Dinsmore
- first_name: Martin
full_name: Dyer, Martin
last_name: Dyer
- first_name: Gabor
full_name: Furesz, Gabor
last_name: Furesz
- first_name: Michelle
full_name: Gabutti, Michelle
last_name: Gabutti
- first_name: James
full_name: Garbutt, James
last_name: Garbutt
- first_name: Juliana
full_name: García-Mejía, Juliana
last_name: García-Mejía
- first_name: Daniel
full_name: Jarvis, Daniel
last_name: Jarvis
- first_name: Mark R.
full_name: Kennedy, Mark R.
last_name: Kennedy
- first_name: Paul
full_name: Kerry, Paul
last_name: Kerry
- first_name: James
full_name: Mccormac, James
last_name: Mccormac
- first_name: Geoffrey
full_name: Mo, Geoffrey
last_name: Mo
- first_name: Dave
full_name: Osip, Dave
last_name: Osip
- first_name: Steven
full_name: Parsons, Steven
last_name: Parsons
- first_name: Eleanor
full_name: Pike, Eleanor
last_name: Pike
- first_name: John J.
full_name: Piotrowski, John J.
last_name: Piotrowski
- first_name: Roger W.
full_name: Romani, Roger W.
last_name: Romani
- first_name: David
full_name: Sahman, David
last_name: Sahman
- first_name: Rob
full_name: Simcoe, Rob
last_name: Simcoe
citation:
ama: Chickles ET, Chakraborty J, Burdge KB, et al. An eclipsing 8.56 minutes orbital
period mass-transferring binary. The Astrophysical Journal. 2026;1000(2).
doi:10.3847/1538-4357/ae4871
apa: Chickles, E. T., Chakraborty, J., Burdge, K. B., Dhillon, V. S., Draghis, P.,
El-Badry, K., … Simcoe, R. (2026). An eclipsing 8.56 minutes orbital period mass-transferring
binary. The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae4871
chicago: Chickles, Emma T., Joheen Chakraborty, Kevin B. Burdge, Vik S. Dhillon,
Paul Draghis, Kareem El-Badry, Matthew J. Green, et al. “An Eclipsing 8.56 Minutes
Orbital Period Mass-Transferring Binary.” The Astrophysical Journal. IOP
Publishing, 2026. https://doi.org/10.3847/1538-4357/ae4871.
ieee: E. T. Chickles et al., “An eclipsing 8.56 minutes orbital period mass-transferring
binary,” The Astrophysical Journal, vol. 1000, no. 2. IOP Publishing, 2026.
ista: Chickles ET, Chakraborty J, Burdge KB, Dhillon VS, Draghis P, El-Badry K,
Green MJ, Householder A, Hughes S, Layden C, Littlefair SP, Munday J, Pelisoli
I, Redden MS, Tonry J, van Roestel JC, Angile FE, Brown AJ, Segura NC, Dinsmore
J, Dyer M, Furesz G, Gabutti M, Garbutt J, García-Mejía J, Jarvis D, Kennedy MR,
Kerry P, Mccormac J, Mo G, Osip D, Parsons S, Pike E, Piotrowski JJ, Romani RW,
Sahman D, Simcoe R. 2026. An eclipsing 8.56 minutes orbital period mass-transferring
binary. The Astrophysical Journal. 1000(2), 237.
mla: Chickles, Emma T., et al. “An Eclipsing 8.56 Minutes Orbital Period Mass-Transferring
Binary.” The Astrophysical Journal, vol. 1000, no. 2, 237, IOP Publishing,
2026, doi:10.3847/1538-4357/ae4871.
short: E.T. Chickles, J. Chakraborty, K.B. Burdge, V.S. Dhillon, P. Draghis, K.
El-Badry, M.J. Green, A. Householder, S. Hughes, C. Layden, S.P. Littlefair, J.
Munday, I. Pelisoli, M.S. Redden, J. Tonry, J.C. van Roestel, F.E. Angile, A.J.
Brown, N.C. Segura, J. Dinsmore, M. Dyer, G. Furesz, M. Gabutti, J. Garbutt, J.
García-Mejía, D. Jarvis, M.R. Kennedy, P. Kerry, J. Mccormac, G. Mo, D. Osip,
S. Parsons, E. Pike, J.J. Piotrowski, R.W. Romani, D. Sahman, R. Simcoe, The Astrophysical
Journal 1000 (2026).
date_created: 2026-04-12T22:01:47Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-04T06:37:12Z
day: '01'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.3847/1538-4357/ae4871
external_id:
arxiv:
- '2601.07925'
file:
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checksum: c8f64a78f36224d8e0ea1f324e43e389
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T06:36:00Z
date_updated: 2026-05-04T06:36:00Z
file_id: '21782'
file_name: 2026_AstrophysicalJournal_Chickles.pdf
file_size: 1225916
relation: main_file
success: 1
file_date_updated: 2026-05-04T06:36:00Z
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intvolume: ' 1000'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: An eclipsing 8.56 minutes orbital period mass-transferring binary
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1000
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21707'
abstract:
- lang: eng
text: Structural and functional differences between brain hemispheres are a common
feature of animal nervous systems with reduced bilateral asymmetry often linked
to impaired cognitive performance. How neuronal left-right asymmetry is initiated
and integrated into a bilaterally symmetrical ground pattern is poorly understood.
Here, we show that the directional asymmetry of a Drosophila central brain circuit
originates from axonal interactions of two types of bilateral pioneer neurons.
Subsequent recruitment of neighboring neurons into the asymmetric neuropil primordium
results in hemisphere-specific microcircuits. Circuit lateralization requires
dynamic expression of the cell adhesion molecule Fasciclin 2 to maintain structural
plasticity in axonal remodeling. Reduced circuit asymmetry following cell type–specific
Fasciclin 2 manipulation affects adult brain function. These results reveal an
unexpected degree of developmental plasticity of late-born Drosophila neurons
in the formation of a circuit node via the lateralized recruitment of symmetric
circuit components.
acknowledgement: "We thank I. Salecker (Flybow), B. Altenhein (Fas2-Gal4Mz507), A.
Nose (UAS-intra- and extra-Fas2::YFP), and C. S. Goodman (UAS-Fas2PEST+/−), as well
as the Bloomington Stock Center for providing materials and fly stocks. We thank
S. Waddell and the lab, especially B. Senapati, for providing the opportunity to
conduct memory experiments at the CNCB, University of Oxford, and for supervision
and discussions during this period. We also thank W. Kallina, S. Ilgerl, D. Bartel,
A. Grimm, and A. Litin for technical support and the Hummel Lab for stimulating
discussions and critical comments on the manuscript. We acknowledge the early exploratory
work of A. Mattia, S. Trkulja, C. Schönherr, S. Bogner, B. Simpson, L. Tomasek,
H. Roth, H. Vokač, R. Gredler, F. Kapelari, T. Kolarova, C. Ignitsch, Á. Bautista-Soldevila,
and M. Kassem.\r\nThis research was funded by the University of Vienna, the Vienna
Doctoral School Cognition, Behaviour and Neuroscience (uni:docs fellowship) (to
J.W.M.) and by the Austrian Science Fund (FWF) (Cluster of Excellence Neuronal Circuits
in Health and Disease, grant DOI 10.55776/COE16; https://www.fwf.ac.at/en/research-radar/10.55776/COE16)
(to T.H.). For open access purposes, the author has applied a CC BY public copyright
license to any author-accepted manuscript version arising from this submission."
article_number: eaea6020
article_processing_charge: Yes
article_type: original
author:
- first_name: Johann W.
full_name: Markovitsch, Johann W.
last_name: Markovitsch
- first_name: Daniel
full_name: Mitić, Daniel
last_name: Mitić
- first_name: Alisa
full_name: Del Pilar Jiménez García, Alisa
last_name: Del Pilar Jiménez García
- first_name: Alsberga
full_name: Zane, Alsberga
id: 60f7509a-f652-11ea-9d86-b963d6490d7c
last_name: Zane
orcid: 0009-0003-0415-7603
- first_name: Sarah
full_name: Kainz, Sarah
last_name: Kainz
- first_name: Rashmit
full_name: Kaur, Rashmit
last_name: Kaur
- first_name: Thomas
full_name: Hummel, Thomas
last_name: Hummel
citation:
ama: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, et al. Sequential formation
of Drosophila circuit asymmetry via prolonged structural plasticity. Science
Advances. 2026;12(13). doi:10.1126/sciadv.aea6020
apa: Markovitsch, J. W., Mitić, D., Del Pilar Jiménez García, A., Zane, A., Kainz,
S., Kaur, R., & Hummel, T. (2026). Sequential formation of Drosophila circuit
asymmetry via prolonged structural plasticity. Science Advances. American
Association for the Advancement of Science. https://doi.org/10.1126/sciadv.aea6020
chicago: Markovitsch, Johann W., Daniel Mitić, Alisa Del Pilar Jiménez García, Alsberga
Zane, Sarah Kainz, Rashmit Kaur, and Thomas Hummel. “Sequential Formation of Drosophila
Circuit Asymmetry via Prolonged Structural Plasticity.” Science Advances.
American Association for the Advancement of Science, 2026. https://doi.org/10.1126/sciadv.aea6020.
ieee: J. W. Markovitsch et al., “Sequential formation of Drosophila circuit
asymmetry via prolonged structural plasticity,” Science Advances, vol.
12, no. 13. American Association for the Advancement of Science, 2026.
ista: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, Zane A, Kainz S, Kaur
R, Hummel T. 2026. Sequential formation of Drosophila circuit asymmetry via prolonged
structural plasticity. Science Advances. 12(13), eaea6020.
mla: Markovitsch, Johann W., et al. “Sequential Formation of Drosophila Circuit
Asymmetry via Prolonged Structural Plasticity.” Science Advances, vol.
12, no. 13, eaea6020, American Association for the Advancement of Science, 2026,
doi:10.1126/sciadv.aea6020.
short: J.W. Markovitsch, D. Mitić, A. Del Pilar Jiménez García, A. Zane, S. Kainz,
R. Kaur, T. Hummel, Science Advances 12 (2026).
date_created: 2026-04-12T22:01:48Z
date_published: 2026-03-27T00:00:00Z
date_updated: 2026-05-04T09:18:06Z
day: '27'
ddc:
- '570'
department:
- _id: MiSi
- _id: GradSch
doi: 10.1126/sciadv.aea6020
file:
- access_level: open_access
checksum: 3eed470fe73e53d2a8d55d6fba6934e3
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T09:16:36Z
date_updated: 2026-05-04T09:16:36Z
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file_name: 2026_ScienceAdv_Markovitsch.pdf
file_size: 11101140
relation: main_file
success: 1
file_date_updated: 2026-05-04T09:16:36Z
has_accepted_license: '1'
intvolume: ' 12'
issue: '13'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Science Advances
publication_identifier:
eissn:
- 2375-2548
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sequential formation of Drosophila circuit asymmetry via prolonged structural
plasticity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21708'
abstract:
- lang: eng
text: On October 4, 2023, a proglacial lake named the South Lhonak lake was the
source of a catastrophic Glacier Lake Outburst Flood (GLOF) in the Teesta river
basin area, resulting in 24 fatalities and leaving over 70 persons missing. The
GLOF also destroyed 13 bridges and a major hydropower plant in the Chungthang
region. Over 60,000 individuals in four districts of Sikkim were impacted by this
GLOF event. This study examines the factors that led to the GLOF event. Our study
shows that the cause of this GLOF was initiated by a landslide, that dumped a
substantial amount (~ 38.31 million m3) of debris into the South Lhonak Lake.
Furthermore, the glacier that was connected to the lake, lost a big chunk of ice
mass (~ 7 million m3) due to calving. The combination of these two processes led
to the collapse of the left lateral moraine that consequently generated flood
waves which breached the terminal moraine dam of the lake. We recommend monitoring
land subsidence and calving events for large proglacial lakes to prevent the disastrous
consequences of such GLOFs in the future.
acknowledgement: This work was carried out independently without the support of any
funding agency or sponsors. The authors thank the SARPROZ team for providing an
evaluation license for the MTInSAR processing software.
article_number: '9741'
article_processing_charge: Yes
article_type: original
author:
- first_name: Litan Kumar
full_name: Mohanty, Litan Kumar
last_name: Mohanty
- first_name: Prateek
full_name: Gantayat, Prateek
id: 02734268-3e8d-11ef-80a1-cec4a088d004
last_name: Gantayat
- first_name: Ankur
full_name: Dixit, Ankur
last_name: Dixit
- first_name: Manik
full_name: Das Adhikari, Manik
last_name: Das Adhikari
- first_name: Rahul
full_name: Biswas, Rahul
last_name: Biswas
- first_name: Vivek Kumar
full_name: Singh, Vivek Kumar
last_name: Singh
citation:
ama: Mohanty LK, GANTAYAT P, Dixit A, Das Adhikari M, Biswas R, Singh VK. Sequence
of events that led to the South Lhonak lake outburst flood in Sikkim, India. Scientific
Reports. 2026;16. doi:10.1038/s41598-026-35895-7
apa: Mohanty, L. K., GANTAYAT, P., Dixit, A., Das Adhikari, M., Biswas, R., &
Singh, V. K. (2026). Sequence of events that led to the South Lhonak lake outburst
flood in Sikkim, India. Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-026-35895-7
chicago: Mohanty, Litan Kumar, PRATEEK GANTAYAT, Ankur Dixit, Manik Das Adhikari,
Rahul Biswas, and Vivek Kumar Singh. “Sequence of Events That Led to the South
Lhonak Lake Outburst Flood in Sikkim, India.” Scientific Reports. Springer
Nature, 2026. https://doi.org/10.1038/s41598-026-35895-7.
ieee: L. K. Mohanty, P. GANTAYAT, A. Dixit, M. Das Adhikari, R. Biswas, and V. K.
Singh, “Sequence of events that led to the South Lhonak lake outburst flood in
Sikkim, India,” Scientific Reports, vol. 16. Springer Nature, 2026.
ista: Mohanty LK, GANTAYAT P, Dixit A, Das Adhikari M, Biswas R, Singh VK. 2026.
Sequence of events that led to the South Lhonak lake outburst flood in Sikkim,
India. Scientific Reports. 16, 9741.
mla: Mohanty, Litan Kumar, et al. “Sequence of Events That Led to the South Lhonak
Lake Outburst Flood in Sikkim, India.” Scientific Reports, vol. 16, 9741,
Springer Nature, 2026, doi:10.1038/s41598-026-35895-7.
short: L.K. Mohanty, P. GANTAYAT, A. Dixit, M. Das Adhikari, R. Biswas, V.K. Singh,
Scientific Reports 16 (2026).
corr_author: '1'
date_created: 2026-04-12T22:01:48Z
date_published: 2026-03-24T00:00:00Z
date_updated: 2026-05-04T07:54:53Z
day: '24'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.1038/s41598-026-35895-7
external_id:
pmid:
- '41876546'
file:
- access_level: open_access
checksum: cf13f61c38609ce6518d74562319c35f
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T07:24:59Z
date_updated: 2026-05-04T07:24:59Z
file_id: '21785'
file_name: 2026_ScienceAdv_Mohanty.pdf
file_size: 17406006
relation: main_file
success: 1
file_date_updated: 2026-05-04T07:24:59Z
has_accepted_license: '1'
intvolume: ' 16'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sequence of events that led to the South Lhonak lake outburst flood in Sikkim,
India
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21709'
abstract:
- lang: eng
text: 'JWST’s “little red dots” (LRDs) are increasingly interpreted as active galactic
nuclei (AGN) obscured by dense thermalized gas rather than dust as evidenced by
their X-ray weakness, blackbody-like continua, and Balmer line profiles. Key questions
are how LRDs connect to standard UV-luminous AGN, whether transitional phases
exist, and whether they are observable. We present the “X-ray dot” (XRD), a compact
source at z = 3.28 observed by the NIRSpec Wide Guaranteed Time Observation survey.
The XRD exhibits LRD hallmarks: a blackbody-like (Teff ≃ 6400 K) red continuum,
a faint but blue rest-UV excess, falling mid-IR emission, and broad Balmer lines
(FWHM ∼ 2700–3200 km s−1). Unlike LRDs, however, it is remarkably X-ray luminous
(L2−10 keV = 1044.18 erg s−1) and has a continuum inflection that is blueward
of the Balmer limit. We find that the red rest-optical and blue mid-IR continuum
cannot be reproduced by standard dust-attenuated AGN models without invoking extremely
steep extinction curves, nor can the weak mid-IR emission be reconciled with well-established
X-ray–torus scaling relations. We therefore consider an alternative scenario:
the XRD may be an LRD in transition, where the gas envelope dominates the optical
continuum but optically thin sight lines allow X-rays to escape. The XRD may thus
provide a physical link between LRDs and standard AGN, offering direct evidence
that LRDs are powered by supermassive black holes and providing insight into their
accretion properties.'
acknowledgement: "We would like to thank the anonymous reviewer for their constructive
comments, which improved the final manuscript.\r\n\r\nWe thank Bernd Husemann for
his critical contributions to the NIRSpec Wide GTO survey, and in particular his
help in selecting high-priority X-ray-luminous targets.\r\n\r\nR.E.H. acknowledges
support by the German Aerospace Center (DLR) and the Federal Ministry for Economic
Affairs and Energy (BMWi) through program 50OR2403 “RUBIES.” A.d.G. acknowledges
support from a Clay Fellowship awarded by the Smithsonian Astrophysical Observatory.
A.J.B. acknowledges funding from the “FirstGalaxies” Advanced grant from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
program (grant agreement No. 789056). R.P.N. thanks Neil Pappalardo and Jane Pappalardo
for their generous support of the MIT Pappalardo Fellowships in Physics. Support
for this work was provided by the Brinson Foundation through a Brinson Prize Fellowship
grant. H.Ü. acknowledges funding by the European Union (ERC APEX, 101164796). Views
and opinions expressed are, however, those of the authors only and do not necessarily
reflect those of the European Union or the European Research Council Executive Agency.
Neither the European Union nor the granting authority can be held responsible for
them. G.V. acknowledges support from European Union’s HE ERC Starting grant No.
101040227—WINGS. B.W. acknowledges support provided by NASA through Hubble Fellowship
grant HST-HF2-51592.001 awarded by the Space Telescope Science Institute, which
is operated by the Association of Universities for Research in Astronomy, In., for
NASA, under the contract NAS 5-26555.\r\n\r\nThe data products presented herein
were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic
Dawn Center (DAWN).\r\n\r\nThis work is based in part on observations made with
the NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski
Archive for Space Telescopes at the Space Telescope Science Institute, which is
operated by the Association of Universities for Research in Astronomy, Inc., under
NASA contract NAS 5-03127 for JWST. These observations are associated with programs
Nos. GTO-1213. The data described here may be obtained from the MAST archive at
DOI: 10.17909/qffz-b324.\r\n\r\nThis Letter employs a list of Chandra datasets,
obtained by the Chandra X-ray Observatory, contained in DOI: 10.25574/cdc.540.\r\n\r\nThis
work is based on observations taken by the 3D-HST Treasury Program (GO 12177 and
12328) with the NASA/ESA HST, which is operated by the Association of Universities
for Research in Astronomy, Inc., under NASA contract NAS5-26555.\r\n\r\nThis work
makes use of color palettes created by Martin Krzywinski designed for colorblindness.
The color palettes and more information can be found at http://mkweb.bcgsc.ca/colorblind/.\r\n\r\nFacilities:
CXO - Chandra X-ray Observatory satellite (ACIS), HST - Hubble Space Telescope satellite
(ACS, WFC3) - , CFHT - Canada-France-Hawaii Telescope (WIRCam), JWST - James Webb
Space Telescope (NIRSpec), Spitzer - Spitzer Space Telescope satellite (IRAC, MIPS)
- , JCMT - James Clerk Maxwell Telescope (SCUBA).\r\n\r\nSoftware: Astropy (Astropy
Collaboration et al. 2013, 2018, 2022), dust_attenuation, dust_extinction (K. Gordon
2024), jax (J. Bradbury et al. 2018), LaTeX (L. Lamport 1994), Matplotlib (J. D.
Hunter 2007), NumPy (T. E. Oliphant 2006; S. van der Walt et al. 2011; C. R. Harris
et al. 2020), NumPyro (D. Phan et al. 2019), scipy (P. Virtanen et al. 2020), sedpy
(B. Johnson & J. Leja 2017), specutils (Astropy-Specutils Development Team 2019),
unite (R. E. Hviding 2025)."
article_number: L18
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Raphael E.
full_name: Hviding, Raphael E.
last_name: Hviding
- first_name: Anna
full_name: De Graaff, Anna
last_name: De Graaff
- first_name: Hanpu
full_name: Liu, Hanpu
last_name: Liu
- first_name: Andy D.
full_name: Goulding, Andy D.
last_name: Goulding
- first_name: Yilun
full_name: Ma, Yilun
last_name: Ma
- first_name: Jenny E.
full_name: Greene, Jenny E.
last_name: Greene
- first_name: Leindert A.
full_name: Boogaard, Leindert A.
last_name: Boogaard
- first_name: Andrew J.
full_name: Bunker, Andrew J.
last_name: Bunker
- first_name: Nikko J.
full_name: Cleri, Nikko J.
last_name: Cleri
- first_name: Marijn
full_name: Franx, Marijn
last_name: Franx
- first_name: Michaela
full_name: Hirschmann, Michaela
last_name: Hirschmann
- first_name: Joel
full_name: Leja, Joel
last_name: Leja
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: Rohan P.
full_name: Naidu, Rohan P.
last_name: Naidu
- first_name: David J.
full_name: Setton, David J.
last_name: Setton
- first_name: Hannah
full_name: Übler, Hannah
last_name: Übler
- first_name: Giacomo
full_name: Venturi, Giacomo
last_name: Venturi
- first_name: Bingjie
full_name: Wang, Bingjie
last_name: Wang
citation:
ama: 'Hviding RE, De Graaff A, Liu H, et al. The X-ray dot: Exotic dust or a late-stage
Little Red Dot? The Astrophysical Journal Letters. 2026;1000(1). doi:10.3847/2041-8213/ae4c88'
apa: 'Hviding, R. E., De Graaff, A., Liu, H., Goulding, A. D., Ma, Y., Greene, J.
E., … Wang, B. (2026). The X-ray dot: Exotic dust or a late-stage Little Red Dot?
The Astrophysical Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae4c88'
chicago: 'Hviding, Raphael E., Anna De Graaff, Hanpu Liu, Andy D. Goulding, Yilun
Ma, Jenny E. Greene, Leindert A. Boogaard, et al. “The X-Ray Dot: Exotic Dust
or a Late-Stage Little Red Dot?” The Astrophysical Journal Letters. IOP
Publishing, 2026. https://doi.org/10.3847/2041-8213/ae4c88.'
ieee: 'R. E. Hviding et al., “The X-ray dot: Exotic dust or a late-stage
Little Red Dot?,” The Astrophysical Journal Letters, vol. 1000, no. 1.
IOP Publishing, 2026.'
ista: 'Hviding RE, De Graaff A, Liu H, Goulding AD, Ma Y, Greene JE, Boogaard LA,
Bunker AJ, Cleri NJ, Franx M, Hirschmann M, Leja J, Matthee JJ, Naidu RP, Setton
DJ, Übler H, Venturi G, Wang B. 2026. The X-ray dot: Exotic dust or a late-stage
Little Red Dot? The Astrophysical Journal Letters. 1000(1), L18.'
mla: 'Hviding, Raphael E., et al. “The X-Ray Dot: Exotic Dust or a Late-Stage Little
Red Dot?” The Astrophysical Journal Letters, vol. 1000, no. 1, L18, IOP
Publishing, 2026, doi:10.3847/2041-8213/ae4c88.'
short: R.E. Hviding, A. De Graaff, H. Liu, A.D. Goulding, Y. Ma, J.E. Greene, L.A.
Boogaard, A.J. Bunker, N.J. Cleri, M. Franx, M. Hirschmann, J. Leja, J.J. Matthee,
R.P. Naidu, D.J. Setton, H. Übler, G. Venturi, B. Wang, The Astrophysical Journal
Letters 1000 (2026).
date_created: 2026-04-12T22:01:48Z
date_published: 2026-03-20T00:00:00Z
date_updated: 2026-05-04T07:13:07Z
day: '20'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/2041-8213/ae4c88
external_id:
arxiv:
- '2601.09778'
file:
- access_level: open_access
checksum: 1be4f361bf59aa08b8c98ed4f475a463
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T07:11:37Z
date_updated: 2026-05-04T07:11:37Z
file_id: '21784'
file_name: 2026_AstrophysicalJourLetters_Hviding.pdf
file_size: 2821786
relation: main_file
success: 1
file_date_updated: 2026-05-04T07:11:37Z
has_accepted_license: '1'
intvolume: ' 1000'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal Letters
publication_identifier:
eissn:
- 2041-8213
issn:
- 2041-8205
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The X-ray dot: Exotic dust or a late-stage Little Red Dot?'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1000
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '21710'
abstract:
- lang: eng
text: "Early results from JWST suggest that Epoch of Reionization (EoR) galaxies
produce copious ionizing photons, which, if they escape efficiently, could cause
reionization to occur too early. We study this problem using JWST imaging and
prism spectroscopy for 412 galaxies at 4.5 < z < 9.0. We fit these data simultaneously
with stellar population and nebular emission models that include a parameter for
the fraction of ionizing photons that escape the galaxy, fesc. We find that the
ionization production efficiency, ξion = Q(H0)/LUV, increases with redshift and
decreasing UV luminosity, but shows significant scatter, (log ion z, MUV) 0.3
dex. The inferred escape fractions averaged over the population are low, ranging
from〈fesc〉 ≃ 2.6% ± 1.4% at 6 < z < 9 to 6.5% ± 2.2% at 4.5 < z < 6, with weak
or no indication of evolution with redshift. This implies that in our models most
of the ionizing photons need to be absorbed to account for the nebular emission.
We compute the impact of our results on reionization, including the distributions
for ξion and fesc, and the evolution and uncertainty of the UV luminosity function.
Considering galaxies brighter than MUV < −16 mag would produce an intergalactic
medium hydrogen-ionized fraction of xe = 0.5 at 5.3 < z < 5.8, possibly too late
compared to constraints from from quasistellar\r\nobject (QSO) sight lines. Including
fainter galaxies, MUV < −14 mag, we obtain xe = 0.5 at 6.0 < z < 8.1, fully consistent
with QSO and cosmic microwave background data. This implies that EoR galaxies
produce plenty of ionizing photons, but that these do not efficiently escape.
This may be a result of high gas column densities combined with burstier star
formation histories, which limit the time massive stars are able to clear channels
through the gas for ionizing photons to escape."
acknowledgement: "We wish to thank our colleagues in the CEERS collaboration for their
hard work and valuable contributions on this project. We extend our sincerest thanks
to the anonymous referee whose critical and constructive report improved the quality
of this manuscript. We also thank the JADES team for providing an excellent dataset
for science. We with to thank colleagues for valuable discussions, feedback, and
suggestions, including John Chisholm, Kevin Huffenberger, Jessica\r\nMeh, Julian
Muñoz, Irene Shivaei, Justin Spilker, Aaron Smith, and Romain Teyssier.\r\nPortions
of this research were conducted with the advanced computing resources provided by
Texas A&M High Performance Research Computing (HPRC, http://hprc.tamu.edu). This
work benefited from support from the George P. and Cynthia Woods Mitchell Institute
for Fundamental Physics and Astronomy at Texas A&M University. CP thanks Marsha
and Ralph Schilling for generous support of this research. This work was partially
support by the Future Investigators in NASA Earth and Space Science and Technology
(FINESST) program grant No. 80NSSC23K1487. R.A. acknowledges support of grant PID2023-147386NB-I00
funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU, and the Severo Ochoa grant
CEX2021-001131-S funded by MCIN/AEI/10.13039/50110001103. A.C.C. acknowledges support
from a UKRI Frontier Research Guarantee Grant (PI Carnall; grant reference EP/Y037065/1)
This work acknowledges support from the NASA/ESA/CSA James Webb Space Telescope
through the\r\nSpace Telescope Science Institute, which is operated by the Association
of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-03127.
Support for program JWST-ERS-01345.009-A, JWST-GO-02079.013-A, JWST-GO-06368.011-A,
and JWST-GO-01837.030-A, was provided by NASA through a grant from the Space Telescope
Science Institute, which is operated by the Association of Universities for Research
in Astronomy, Inc., under NASA contract NAS 5-03127. This work made use of v2.2
of the Binary Population\r\nand Spectral Synthesis (BPASS) models as described in
E. R. Stanway & J. J. Eldridge (2018)."
article_number: '111'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Casey
full_name: Papovich, Casey
last_name: Papovich
- first_name: Justin W.
full_name: Cole, Justin W.
last_name: Cole
- first_name: Weida
full_name: Hu, Weida
last_name: Hu
- first_name: Steven L.
full_name: Finkelstein, Steven L.
last_name: Finkelstein
- first_name: Lu
full_name: Shen, Lu
last_name: Shen
- first_name: Pablo
full_name: Arrabal Haro, Pablo
last_name: Arrabal Haro
- first_name: Ricardo O.
full_name: Amorín, Ricardo O.
last_name: Amorín
- first_name: Bren E.
full_name: Backhaus, Bren E.
last_name: Backhaus
- first_name: Micaela B.
full_name: Bagley, Micaela B.
last_name: Bagley
- first_name: Rachana
full_name: Bhatawdekar, Rachana
last_name: Bhatawdekar
- first_name: Antonello
full_name: Calabrò, Antonello
last_name: Calabrò
- first_name: Adam C.
full_name: Carnall, Adam C.
last_name: Carnall
- first_name: Nikko J.
full_name: Cleri, Nikko J.
last_name: Cleri
- first_name: Emanuele
full_name: Daddi, Emanuele
last_name: Daddi
- first_name: Mark
full_name: Dickinson, Mark
last_name: Dickinson
- first_name: Norman A.
full_name: Grogin, Norman A.
last_name: Grogin
- first_name: Benne W.
full_name: Holwerda, Benne W.
last_name: Holwerda
- first_name: Anne E.
full_name: Jaskot, Anne E.
last_name: Jaskot
- first_name: Anton M.
full_name: Koekemoer, Anton M.
last_name: Koekemoer
- first_name: Mario
full_name: Llerena, Mario
last_name: Llerena
- first_name: Ray A.
full_name: Lucas, Ray A.
last_name: Lucas
- first_name: Sara
full_name: Mascia, Sara
id: edaf889c-c7cd-11ef-ab1b-bb28c431bd29
last_name: Mascia
- first_name: Fabio
full_name: Pacucci, Fabio
last_name: Pacucci
- first_name: Laura
full_name: Pentericci, Laura
last_name: Pentericci
- first_name: Pablo G.
full_name: Pérez-González, Pablo G.
last_name: Pérez-González
- first_name: Nor
full_name: Pirzkal, Nor
last_name: Pirzkal
- first_name: Srinivasan
full_name: Raghunathan, Srinivasan
last_name: Raghunathan
- first_name: Lise Marie
full_name: Seillé, Lise Marie
last_name: Seillé
- first_name: Rachel S.
full_name: Somerville, Rachel S.
last_name: Somerville
- first_name: L. Y.Aaron
full_name: Yung, L. Y.Aaron
last_name: Yung
citation:
ama: Papovich C, Cole JW, Hu W, et al. Galaxies in the epoch of reionization are
all bark and no bite-plenty of ionizing photons, low escape fractions. The
Astrophysical Journal. 2026;1000(1). doi:10.3847/1538-4357/ae3b25
apa: Papovich, C., Cole, J. W., Hu, W., Finkelstein, S. L., Shen, L., Arrabal Haro,
P., … Yung, L. Y. A. (2026). Galaxies in the epoch of reionization are all bark
and no bite-plenty of ionizing photons, low escape fractions. The Astrophysical
Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae3b25
chicago: Papovich, Casey, Justin W. Cole, Weida Hu, Steven L. Finkelstein, Lu Shen,
Pablo Arrabal Haro, Ricardo O. Amorín, et al. “Galaxies in the Epoch of Reionization
Are All Bark and No Bite-Plenty of Ionizing Photons, Low Escape Fractions.” The
Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae3b25.
ieee: C. Papovich et al., “Galaxies in the epoch of reionization are all
bark and no bite-plenty of ionizing photons, low escape fractions,” The Astrophysical
Journal, vol. 1000, no. 1. IOP Publishing, 2026.
ista: Papovich C, Cole JW, Hu W, Finkelstein SL, Shen L, Arrabal Haro P, Amorín
RO, Backhaus BE, Bagley MB, Bhatawdekar R, Calabrò A, Carnall AC, Cleri NJ, Daddi
E, Dickinson M, Grogin NA, Holwerda BW, Jaskot AE, Koekemoer AM, Llerena M, Lucas
RA, Mascia S, Pacucci F, Pentericci L, Pérez-González PG, Pirzkal N, Raghunathan
S, Seillé LM, Somerville RS, Yung LYA. 2026. Galaxies in the epoch of reionization
are all bark and no bite-plenty of ionizing photons, low escape fractions. The
Astrophysical Journal. 1000(1), 111.
mla: Papovich, Casey, et al. “Galaxies in the Epoch of Reionization Are All Bark
and No Bite-Plenty of Ionizing Photons, Low Escape Fractions.” The Astrophysical
Journal, vol. 1000, no. 1, 111, IOP Publishing, 2026, doi:10.3847/1538-4357/ae3b25.
short: C. Papovich, J.W. Cole, W. Hu, S.L. Finkelstein, L. Shen, P. Arrabal Haro,
R.O. Amorín, B.E. Backhaus, M.B. Bagley, R. Bhatawdekar, A. Calabrò, A.C. Carnall,
N.J. Cleri, E. Daddi, M. Dickinson, N.A. Grogin, B.W. Holwerda, A.E. Jaskot, A.M.
Koekemoer, M. Llerena, R.A. Lucas, S. Mascia, F. Pacucci, L. Pentericci, P.G.
Pérez-González, N. Pirzkal, S. Raghunathan, L.M. Seillé, R.S. Somerville, L.Y.A.
Yung, The Astrophysical Journal 1000 (2026).
date_created: 2026-04-12T22:01:49Z
date_published: 2026-03-20T00:00:00Z
date_updated: 2026-05-04T10:44:57Z
day: '20'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ae3b25
external_id:
arxiv:
- '2505.08870'
file:
- access_level: open_access
checksum: 0031a6f197a3fa8c2845de10b6bdc696
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T10:40:07Z
date_updated: 2026-05-04T10:40:07Z
file_id: '21791'
file_name: 2026_AstrophysicalJour_Papovich.pdf
file_size: 6670398
relation: main_file
success: 1
file_date_updated: 2026-05-04T10:40:07Z
has_accepted_license: '1'
intvolume: ' 1000'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Galaxies in the epoch of reionization are all bark and no bite-plenty of ionizing
photons, low escape fractions
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1000
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21711'
abstract:
- lang: eng
text: 'Background: Low-volume trapping columns are essential for sample enrichment,
desalting, and injection profile focusing on nano-LC–MS-based proteomics. They
enable higher sample loading, improve chromatographic performance, and protect
the analytical column by removing salts and contaminants. Recently, monolithic
trap columns with micropillar architecture have emerged as alternatives to conventionally
packed traps. This study compares the performance of a packed and a micropillar
monolithic trap column for the analysis of tryptic peptides. Methods: A tryptic
digest of HeLa cell lysate was analyzed under identical LC–MS conditions using
both trap types. Peptides were detected at 214 nm and analyzed by nano-ESI on
a Q Exactive Plus Orbitrap. Data were searched against the human UniProt database
(February 2023) using FragPipe v20.0, and statistical evaluation of MaxLFQ intensities
was performed in Perseus using Welch’s t-test and clustering analysis. Results:
Over 2500 proteins were identified with both setups. The packed trap column yielded
more total peptides, particularly those with post-translational modifications
and higher hydrophilicity, whereas the monolithic column favored peptides of intermediate
hydrophobicity. Chromatographic profiles confirmed a slight reduction in the trapping
efficiency of hydrophilic peptides by the monolithic trap. Conclusions: Trap column
design significantly influences peptide recovery and proteome coverage.'
acknowledgement: 'The authors thank Gábor Tóth, Uppsala University, Sweden, and Armel
Nicolas, Institute for Science and Technology Austria, for their support. This research
was conducted during a student residency in Vienna under the auspices of OeAD. ZI:
ICM-2016-03196.'
article_number: '10'
article_processing_charge: Yes
article_type: original
author:
- first_name: Jadranka
full_name: Miletić Vukajlović, Jadranka
last_name: Miletić Vukajlović
- first_name: Bojana
full_name: Ilić, Bojana
last_name: Ilić
- first_name: Bella
full_name: Bruszel, Bella
id: 70abbbb3-88ea-11ec-8e0a-e8c939944834
last_name: Bruszel
- first_name: Tanja
full_name: Panić-Janković, Tanja
last_name: Panić-Janković
- first_name: Goran
full_name: Mitulović, Goran
last_name: Mitulović
citation:
ama: Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. Comparison
of the trapping efficiency for tryptic peptides on particle-packed and micro-pillar
trap columns for proteomics analyses. Proteomes. 2026;14(1). doi:10.3390/proteomes14010010
apa: Miletić Vukajlović, J., Ilić, B., Bruszel, B., Panić-Janković, T., & Mitulović,
G. (2026). Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses. Proteomes. MDPI.
https://doi.org/10.3390/proteomes14010010
chicago: Miletić Vukajlović, Jadranka, Bojana Ilić, Bella Bruszel, Tanja Panić-Janković,
and Goran Mitulović. “Comparison of the Trapping Efficiency for Tryptic Peptides
on Particle-Packed and Micro-Pillar Trap Columns for Proteomics Analyses.” Proteomes.
MDPI, 2026. https://doi.org/10.3390/proteomes14010010.
ieee: J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, and G. Mitulović,
“Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses,” Proteomes, vol.
14, no. 1. MDPI, 2026.
ista: Miletić Vukajlović J, Ilić B, Bruszel B, Panić-Janković T, Mitulović G. 2026.
Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses. Proteomes. 14(1), 10.
mla: Miletić Vukajlović, Jadranka, et al. “Comparison of the Trapping Efficiency
for Tryptic Peptides on Particle-Packed and Micro-Pillar Trap Columns for Proteomics
Analyses.” Proteomes, vol. 14, no. 1, 10, MDPI, 2026, doi:10.3390/proteomes14010010.
short: J. Miletić Vukajlović, B. Ilić, B. Bruszel, T. Panić-Janković, G. Mitulović,
Proteomes 14 (2026).
date_created: 2026-04-12T22:01:49Z
date_published: 2026-03-01T00:00:00Z
date_updated: 2026-05-04T10:36:21Z
day: '01'
ddc:
- '540'
department:
- _id: MassSpec
doi: 10.3390/proteomes14010010
external_id:
pmid:
- '41893725'
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- access_level: open_access
checksum: 1e0c66bbf4b6e0be626a8639ea664b63
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T10:31:35Z
date_updated: 2026-05-04T10:31:35Z
file_id: '21790'
file_name: 2026_Proteomes_Vukajlovic.pdf
file_size: 1009723
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success: 1
file_date_updated: 2026-05-04T10:31:35Z
has_accepted_license: '1'
intvolume: ' 14'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
publication: Proteomes
publication_identifier:
eissn:
- 2227-7382
publication_status: published
publisher: MDPI
quality_controlled: '1'
scopus_import: '1'
status: public
title: Comparison of the trapping efficiency for tryptic peptides on particle-packed
and micro-pillar trap columns for proteomics analyses
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21712'
abstract:
- lang: eng
text: Supermassive black hole binary (SMBHB) systems are expected to form as a consequence
of galaxy mergers. At subparsec separations, SMBHBs can be identified as quasars
with periodic variability, with previous periodicity searches uncovering significant
candidates. However, these searches focused primarily on sinusoidal signals, while
theoretical models and hydrodynamical simulations predict that binaries produce
more complex non-sinusoidal pulse shapes. Here we examine the efficacy of the
Lomb–Scargle periodogram (LSP; one of the most popular tools for periodicity searches
in unevenly sampled lightcurves) to detect periodicities with a sawtooth shape
mimicking results of hydrodynamical simulations. We simulate idealized well-sampled
lightcurves, lightcurves that mimic the data in the Palomar Transient Factory
(PTF) analyzed in M. Charisi et al. (2016), and lightcurves that resemble our
expectations for single-band data in the upcoming Legacy Survey of Space and Time
(LSST) of the Rubin Observatory. We approximate quasar variability with a damped
random walk (DRW) model, inject sinusoidal and sawtooth pulse shapes, and assess
their statistical significance. We find that in the presence of red noise, the
LSP detects a relatively low fraction of the sinusoidal signals (∼45%, ∼24%, and
∼23%, in the PTF-like, idealized, and LSST-like lightcurves, respectively). The
fraction is significantly reduced for sawtooth periodicity (with only ∼9% in PTF-like
and ∼1% in idealized and LSST-like lightcurves). These low recovery rates imply
that previous searches have missed the large majority of binaries. They also have
significant implications for the detection of SMBHBs in upcoming LSST necessitating
the development of advanced tools that go beyond the simple LSP.
acknowledgement: M.C. acknowledges support by the European Union (ERC; MMMonsters,
101117624). This work was also supported in part by NASA grants 80NSSC24K0440 and
80NSSC22K0822. This research used the resources of the Center for Institutional
Research Computing at Washington State University.
article_number: '316'
article_processing_charge: Yes
article_type: original
author:
- first_name: Allison
full_name: Lin, Allison
last_name: Lin
- first_name: Maria
full_name: Charisi, Maria
last_name: Charisi
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
citation:
ama: Lin A, Charisi M, Haiman Z. Lomb-scargle periodogram struggles with non-sinusoidal
supermassive Black Hole binary signatures in quasar lightcurves. The Astrophysical
Journal. 2026;997(2). doi:10.3847/1538-4357/ae29a7
apa: Lin, A., Charisi, M., & Haiman, Z. (2026). Lomb-scargle periodogram struggles
with non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves.
The Astrophysical Journal. IOP Publishing. https://doi.org/10.3847/1538-4357/ae29a7
chicago: Lin, Allison, Maria Charisi, and Zoltán Haiman. “Lomb-Scargle Periodogram
Struggles with Non-Sinusoidal Supermassive Black Hole Binary Signatures in Quasar
Lightcurves.” The Astrophysical Journal. IOP Publishing, 2026. https://doi.org/10.3847/1538-4357/ae29a7.
ieee: A. Lin, M. Charisi, and Z. Haiman, “Lomb-scargle periodogram struggles with
non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves,”
The Astrophysical Journal, vol. 997, no. 2. IOP Publishing, 2026.
ista: Lin A, Charisi M, Haiman Z. 2026. Lomb-scargle periodogram struggles with
non-sinusoidal supermassive Black Hole binary signatures in quasar lightcurves.
The Astrophysical Journal. 997(2), 316.
mla: Lin, Allison, et al. “Lomb-Scargle Periodogram Struggles with Non-Sinusoidal
Supermassive Black Hole Binary Signatures in Quasar Lightcurves.” The Astrophysical
Journal, vol. 997, no. 2, 316, IOP Publishing, 2026, doi:10.3847/1538-4357/ae29a7.
short: A. Lin, M. Charisi, Z. Haiman, The Astrophysical Journal 997 (2026).
date_created: 2026-04-12T22:01:49Z
date_published: 2026-02-01T00:00:00Z
date_updated: 2026-05-04T10:26:59Z
day: '01'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/1538-4357/ae29a7
file:
- access_level: open_access
checksum: 5162d1539ef7d10927ef73d8b4500017
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T10:24:49Z
date_updated: 2026-05-04T10:24:49Z
file_id: '21789'
file_name: 2026_AstrophysicalJour_Lin.pdf
file_size: 2619679
relation: main_file
success: 1
file_date_updated: 2026-05-04T10:24:49Z
has_accepted_license: '1'
intvolume: ' 997'
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
eissn:
- 1538-4357
issn:
- 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Lomb-scargle periodogram struggles with non-sinusoidal supermassive Black Hole
binary signatures in quasar lightcurves
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 997
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21713'
abstract:
- lang: eng
text: GW231123 represents the most massive binary–black hole merger detected to
date, lying firmly within, or even above, the pair-instability mass gap. The component
spins are both exceptionally high (a1 = 0.90 +0.10/-0.19, a2 = 0.80 +0.20/-0.51),
which is difficult to explain with repeated mergers. Here we show that the black
hole spin vectors are closely aligned with each other while significantly tilted
relative to the binary’s orbital angular momentum, pointing to a common accretion-driven
origin. We examine astrophysical formation channels capable of producing near-equal,
high-mass, and mutually aligned spins consistent with GW231123—particularly binaries
embedded in AGN disks and Population III remnants, which grew via coherent misaligned
gas accretion. We further argue that other high-mass, high-spin events, e.g.,
GW190521, may share a similar evolutionary pathway. These findings underscore
the critical role of sustained, coherent accretion in shaping the most extreme
black hole binaries.
acknowledgement: The authors thank Davide Gerosa and Matthew Mould for valuable suggestions.
We are grateful for support by the National Science Foundation under grant No. PHY-2309024
(I.B.) and by NASA under grants 80NSSC22K0822 and 80NSSC24K0440 (Z.H.). We used
OpenAI’s ChatGPT (OpenAI 2025) during the preparation of this manuscript. This material
is based upon work supported by NSF’s LIGO Laboratory, which is a major facility
fully funded by the National Science Foundation.
article_number: L44
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Imre
full_name: Bartos, Imre
last_name: Bartos
- first_name: Zoltán
full_name: Haiman, Zoltán
id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
last_name: Haiman
orcid: 0000-0003-3633-5403
citation:
ama: 'Bartos I, Haiman Z. Accretion is all you need: Black Hole spin alignment in
merger GW231123 indicates accretion pathway. The Astrophysical Journal Letters.
2026;996(2). doi:10.3847/2041-8213/ae2bff'
apa: 'Bartos, I., & Haiman, Z. (2026). Accretion is all you need: Black Hole
spin alignment in merger GW231123 indicates accretion pathway. The Astrophysical
Journal Letters. IOP Publishing. https://doi.org/10.3847/2041-8213/ae2bff'
chicago: 'Bartos, Imre, and Zoltán Haiman. “Accretion Is All You Need: Black Hole
Spin Alignment in Merger GW231123 Indicates Accretion Pathway.” The Astrophysical
Journal Letters. IOP Publishing, 2026. https://doi.org/10.3847/2041-8213/ae2bff.'
ieee: 'I. Bartos and Z. Haiman, “Accretion is all you need: Black Hole spin alignment
in merger GW231123 indicates accretion pathway,” The Astrophysical Journal
Letters, vol. 996, no. 2. IOP Publishing, 2026.'
ista: 'Bartos I, Haiman Z. 2026. Accretion is all you need: Black Hole spin alignment
in merger GW231123 indicates accretion pathway. The Astrophysical Journal Letters.
996(2), L44.'
mla: 'Bartos, Imre, and Zoltán Haiman. “Accretion Is All You Need: Black Hole Spin
Alignment in Merger GW231123 Indicates Accretion Pathway.” The Astrophysical
Journal Letters, vol. 996, no. 2, L44, IOP Publishing, 2026, doi:10.3847/2041-8213/ae2bff.'
short: I. Bartos, Z. Haiman, The Astrophysical Journal Letters 996 (2026).
corr_author: '1'
date_created: 2026-04-12T22:01:49Z
date_published: 2026-01-10T00:00:00Z
date_updated: 2026-05-04T09:54:18Z
day: '10'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/2041-8213/ae2bff
external_id:
arxiv:
- '2508.08558'
file:
- access_level: open_access
checksum: ac46ba3d13f0150ccbc42665bed3ae47
content_type: application/pdf
creator: dernst
date_created: 2026-05-04T09:49:53Z
date_updated: 2026-05-04T09:49:53Z
file_id: '21788'
file_name: 2026_AstrophysicalJourLetters_Bartos.pdf
file_size: 866725
relation: main_file
success: 1
file_date_updated: 2026-05-04T09:49:53Z
has_accepted_license: '1'
intvolume: ' 996'
issue: '2'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal Letters
publication_identifier:
eissn:
- 2041-8213
issn:
- 2041-8205
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Accretion is all you need: Black Hole spin alignment in merger GW231123 indicates
accretion pathway'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 996
year: '2026'
...