---
OA_place: publisher
OA_type: hybrid
_id: '21839'
abstract:
- lang: eng
  text: "Background & Aims: To develop and validate a CT-based radiomics model to
    assess HVPG and predict a composite endpoint of liver-related events (LRE: decompensation
    and liver-related death) in patients with cirrhosis.\r\n\r\nMethods: This retrospective
    study included 357 cirrhosis patients, who received invasive HVPG measurements,
    120 liver-healthy controls (training cohort) and 85 and 100 cirrhosis patients
    (internal and external validation cohorts, respectively), and contrast-enhanced
    abdominal CTs. After volumetric segmentation of the liver and spleen on CT, Bayesian
    parameter optimization was used for selection of extracted features and hyperparameter
    tuning in random forest or elastic net models. Prediction accuracy was evaluated
    using Pearson correlation coefficients of predicted (’radio-HVPG’) and invasive
    HVPG. Discrimination between relevant HVPG cut-offs was determined by receiver
    operating characteristic (ROC) analysis. The predictive value of radio-HVPG and
    invasive-HVPG for LRE was compared using Cox regression models.\r\n\r\nResults:
    Radio-HVPG, predicted by an optimized random forest model based on 74 selected
    CT features, correlated with invasive-HVPG and detected clinically significant
    portal hypertension (CSPH: HVPG ≥ 10 mmHg) on the internal (Pearson r = 0.63,
    AUC 0.89 [95% CI: 0.81–0.96]) and external (Pearson r = 0.62, AUC 0.80 [95% CI:
    0.64–0.91]) validation cohorts. Radio-HVPG predicted LRE when adjusting for MELD
    and albumin (adjusted HR: 1.14 [95% CI: 1.04–1.25], p = 0.005) and performed similarly
    to invasive-HVPG.\r\n\r\nConclusions: Radiomic features accurately predict HVPG
    in patients with cirrhosis and allow risk stratification for LRE in a radiomics-clinical
    signature."
acknowledgement: "The computational results presented were partly obtained using the
  CLIP cluster (https://clip.science/). The authors thank Clemens Watzenboeck from
  the Medical University of Vienna for the assistance in code upload and repository
  maintenance. The authors dedicate this work to the memory of Martin Watzenboeck,
  who served as first author and whose vision and scientific rigor were fundamental
  to the conception and completion of this study. Open Access funding provided by
  Medizinische Universitat Wien/KEMÖ. This work was supported by the Vienna Science
  and Technology Fund (WWTF) through projects VRG15-005 and NXT 19-008 granted to
  J.M and the Clinical Research Group MOTION, Medical University of Vienna, Vienna,
  Austria – a Clinical Research Group Programme project funded by the Ludwig Boltzmann
  Gesellschaft (Grant Nr LBG_KFG_22_32) with funds from the Fonds Zukunft Österreich.\r\n\r\nP-E.R.'s
  research laboratory is supported by the Fondation pour la Recherche Médicale (FRM
  EQU202303016287), “Institut National de la Santé et de la Recherche Médicale” (ATIP
  AVENIR), the “Agence Nationale de la Recherche” (ANR-18-CE14-0006-01, RHU QUID-NASH,
  ANR-18-IDEX-0001, ANR-22-CE14-0002) by « Émergence, Ville de Paris », by Fondation
  ARC, by the European Union's Horizon 2020 research and innovation programme under
  grant agreement No 847949 and by France 2030 RHU LIVER-TRACK."
article_number: e70633
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Celine
  full_name: Sin, Celine
  last_name: Sin
- first_name: Martin Luther
  full_name: Watzenboeck, Martin Luther
  last_name: Watzenboeck
- first_name: Eugenia B
  full_name: Iofinova, Eugenia B
  id: f9a17499-f6e0-11ea-865d-fdf9a3f77117
  last_name: Iofinova
  orcid: 0000-0002-7778-3221
- first_name: Lorenz
  full_name: Balcar, Lorenz
  last_name: Balcar
- first_name: Georg
  full_name: Semmler, Georg
  last_name: Semmler
- first_name: Bernhard
  full_name: Scheiner, Bernhard
  last_name: Scheiner
- first_name: Katharina
  full_name: Lampichler, Katharina
  last_name: Lampichler
- first_name: Mattias
  full_name: Mandorfer, Mattias
  last_name: Mandorfer
- first_name: Lucile
  full_name: Moga, Lucile
  last_name: Moga
- first_name: Pierre‐Emmanuel
  full_name: Rautou, Pierre‐Emmanuel
  last_name: Rautou
- first_name: Maxime
  full_name: Ronot, Maxime
  last_name: Ronot
- first_name: Jörg
  full_name: Menche, Jörg
  last_name: Menche
- first_name: Thomas
  full_name: Reiberger, Thomas
  last_name: Reiberger
- first_name: Martina
  full_name: Scharitzer, Martina
  last_name: Scharitzer
citation:
  ama: Sin C, Watzenboeck ML, Iofinova EB, et al. Radiomics‐based assessment of portal
    hypertension severity and risk stratification of cirrhotic patients using routine
    CT scans. <i>Liver International</i>. 2026;46(5). doi:<a href="https://doi.org/10.1111/liv.70633">10.1111/liv.70633</a>
  apa: Sin, C., Watzenboeck, M. L., Iofinova, E. B., Balcar, L., Semmler, G., Scheiner,
    B., … Scharitzer, M. (2026). Radiomics‐based assessment of portal hypertension
    severity and risk stratification of cirrhotic patients using routine CT scans.
    <i>Liver International</i>. Wiley. <a href="https://doi.org/10.1111/liv.70633">https://doi.org/10.1111/liv.70633</a>
  chicago: Sin, Celine, Martin Luther Watzenboeck, Eugenia B Iofinova, Lorenz Balcar,
    Georg Semmler, Bernhard Scheiner, Katharina Lampichler, et al. “Radiomics‐based
    Assessment of Portal Hypertension Severity and Risk Stratification of Cirrhotic
    Patients Using Routine CT Scans.” <i>Liver International</i>. Wiley, 2026. <a
    href="https://doi.org/10.1111/liv.70633">https://doi.org/10.1111/liv.70633</a>.
  ieee: C. Sin <i>et al.</i>, “Radiomics‐based assessment of portal hypertension severity
    and risk stratification of cirrhotic patients using routine CT scans,” <i>Liver
    International</i>, vol. 46, no. 5. Wiley, 2026.
  ista: Sin C, Watzenboeck ML, Iofinova EB, Balcar L, Semmler G, Scheiner B, Lampichler
    K, Mandorfer M, Moga L, Rautou P, Ronot M, Menche J, Reiberger T, Scharitzer M.
    2026. Radiomics‐based assessment of portal hypertension severity and risk stratification
    of cirrhotic patients using routine CT scans. Liver International. 46(5), e70633.
  mla: Sin, Celine, et al. “Radiomics‐based Assessment of Portal Hypertension Severity
    and Risk Stratification of Cirrhotic Patients Using Routine CT Scans.” <i>Liver
    International</i>, vol. 46, no. 5, e70633, Wiley, 2026, doi:<a href="https://doi.org/10.1111/liv.70633">10.1111/liv.70633</a>.
  short: C. Sin, M.L. Watzenboeck, E.B. Iofinova, L. Balcar, G. Semmler, B. Scheiner,
    K. Lampichler, M. Mandorfer, L. Moga, P. Rautou, M. Ronot, J. Menche, T. Reiberger,
    M. Scharitzer, Liver International 46 (2026).
date_created: 2026-05-07T08:51:47Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-18T07:20:20Z
day: '01'
ddc:
- '570'
doi: 10.1111/liv.70633
external_id:
  pmid:
  - '41943460'
file:
- access_level: open_access
  checksum: fafcc0b88b8e8caed85849627305d9ba
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-18T07:10:31Z
  date_updated: 2026-05-18T07:10:31Z
  file_id: '21888'
  file_name: 2026_LiverInternational_Sin.pdf
  file_size: 3550462
  relation: main_file
  success: 1
file_date_updated: 2026-05-18T07:10:31Z
has_accepted_license: '1'
intvolume: '        46'
issue: '5'
keyword:
- computed tomography
- liver
- portal hypertension
- radiomics
- spleen
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Liver International
publication_identifier:
  eissn:
  - 1478-3231
  issn:
  - 1478-3223
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Radiomics‐based assessment of portal hypertension severity and risk stratification
  of cirrhotic patients using routine CT scans
tmp:
  image: /images/cc_by_nc_nd.png
  legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 46
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21840'
abstract:
- lang: eng
  text: The transport properties of nanofluidic channels are usually studied under
    constant (DC) voltage or pressure driving. However, the frequency response under
    sinusoidal (AC) drivings offers rich insights into the time-dependent transport
    mechanisms. Inspired by recent electrochemical approaches, we investigate the
    couplings between ionic and electronic transport under AC driving. We show that
    conduction electrons of the channel walls participate in ionic current via capacitive
    electrochemical coupling, defining a critical frequency and length scale where
    electron-dominated conductivity emerges. We further analyze how electron–ion coupling
    modifies electro-osmotic flows and demonstrate that fluctuation-induced momentum
    transfer between the electrolyte and wall electrons produces distinct AC transport
    signatures, depending on the charge carrier polarity. Altogether, we establish
    a frequency-dependent transport matrix that couples ionic, electronic, and hydrodynamic
    flows. These findings establish AC nanofluidic transport as a powerful probe of
    interfacial phenomena under confinement and suggest new directions for engineering
    nanofluidic functionalities through electron–electrolyte coupling.
acknowledgement: The authors thank Nicolas Chapuis for fruitful discussions. L.B.
  acknowledges support from the ERC project n-AQUA under Grant Agreement No. 101071937.
  B.C. acknowledges support from the CFM Foundation and the NOMIS Foundation. N.K.
  acknowledges support from the Swiss National Science Foundation (SNSF) under Grant
  No. CRSK-2_237930.
article_number: '134704'
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Baptiste
  full_name: Coquinot, Baptiste
  id: f8417bd4-f599-11ee-a482-b927e3ed1e8e
  last_name: Coquinot
  orcid: 0000-0001-5524-596X
- first_name: Mathieu
  full_name: Lizée, Mathieu
  last_name: Lizée
- first_name: Lydéric
  full_name: Bocquet, Lydéric
  last_name: Bocquet
- first_name: Nikita
  full_name: Kavokine, Nikita
  last_name: Kavokine
citation:
  ama: Coquinot B, Lizée M, Bocquet L, Kavokine N. Electron–electrolyte coupling in
    AC transport through nanofluidic channels. <i>The Journal of Chemical Physics</i>.
    2026;164(13). doi:<a href="https://doi.org/10.1063/5.0313352">10.1063/5.0313352</a>
  apa: Coquinot, B., Lizée, M., Bocquet, L., &#38; Kavokine, N. (2026). Electron–electrolyte
    coupling in AC transport through nanofluidic channels. <i>The Journal of Chemical
    Physics</i>. AIP Publishing. <a href="https://doi.org/10.1063/5.0313352">https://doi.org/10.1063/5.0313352</a>
  chicago: Coquinot, Baptiste, Mathieu Lizée, Lydéric Bocquet, and Nikita Kavokine.
    “Electron–Electrolyte Coupling in AC Transport through Nanofluidic Channels.”
    <i>The Journal of Chemical Physics</i>. AIP Publishing, 2026. <a href="https://doi.org/10.1063/5.0313352">https://doi.org/10.1063/5.0313352</a>.
  ieee: B. Coquinot, M. Lizée, L. Bocquet, and N. Kavokine, “Electron–electrolyte
    coupling in AC transport through nanofluidic channels,” <i>The Journal of Chemical
    Physics</i>, vol. 164, no. 13. AIP Publishing, 2026.
  ista: Coquinot B, Lizée M, Bocquet L, Kavokine N. 2026. Electron–electrolyte coupling
    in AC transport through nanofluidic channels. The Journal of Chemical Physics.
    164(13), 134704.
  mla: Coquinot, Baptiste, et al. “Electron–Electrolyte Coupling in AC Transport through
    Nanofluidic Channels.” <i>The Journal of Chemical Physics</i>, vol. 164, no. 13,
    134704, AIP Publishing, 2026, doi:<a href="https://doi.org/10.1063/5.0313352">10.1063/5.0313352</a>.
  short: B. Coquinot, M. Lizée, L. Bocquet, N. Kavokine, The Journal of Chemical Physics
    164 (2026).
date_created: 2026-05-07T08:53:03Z
date_published: 2026-04-07T00:00:00Z
date_updated: 2026-05-18T07:34:57Z
day: '07'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1063/5.0313352
external_id:
  arxiv:
  - '2505.02478'
file:
- access_level: open_access
  checksum: a896969c829be2a79859bd277f87b44c
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-18T07:31:23Z
  date_updated: 2026-05-18T07:31:23Z
  file_id: '21889'
  file_name: 2026_JourChemPhysics_Coquinot.pdf
  file_size: 5497515
  relation: main_file
  success: 1
file_date_updated: 2026-05-18T07:31:23Z
has_accepted_license: '1'
intvolume: '       164'
issue: '13'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: The Journal of Chemical Physics
publication_identifier:
  eissn:
  - 1089-7690
  issn:
  - 0021-9606
publication_status: published
publisher: AIP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Electron–electrolyte coupling in AC transport through nanofluidic channels
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 164
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21841'
abstract:
- lang: eng
  text: The long-standing notion that genotypes map to phenotypes through simple one
    gene–one trait relationships continues to shape both research in the life sciences
    and public understanding, with implications for policy and funding priorities.
    Yet this paradigm is increasingly recognized as inadequate for explaining continuous
    phenotypic variation and the complex genetic architectures of the genotype–phenotype
    map. Modern genetics emerged from the early 20th-century synthesis of Mendelian
    and biometric schools of heredity, with R.A. Fisher demonstrating early on how
    multiple discrete loci could collectively produce continuous variation. Despite
    this fundamental insight, Mendelism—with its focus on single genes and standardized
    genetic backgrounds—became the dominant framework, shaping current genetics research
    and molecular biology as well as science education. The advent of large-scale
    genomic data has revealed yet again the limitations of this reductionist approach.
    Evidence from quantitative genetics now shows that most phenotypes arise from
    complex networks of many interdependent genes and their dynamic responses to environmental
    perturbations. Here we trace the historical roots of how Mendelian classical genetics
    departed from the biometric school to create the current predominant paradigm
    in genetics, despite fundamentally unresolved issues. Moving on from this one-sided
    paradigm will require systematic development of integrative, evolutionarily grounded
    experimental approaches that better capture the multigenic and context-dependent
    nature of inheritance. Achieving such an extended perspective will require methodological
    innovation, including advances in large-scale (e.g. automated) phenotyping. Dedicated
    research programs will be necessary to advance a new era of genetic research into
    the complex mechanisms underlying phenotypic variation.
acknowledgement: We thank a variety of further colleagues for the many inspiring discussions
  on the nature of heredity, especially the workshops in Berlin. Special thanks also
  to the Stellenbosch Institute for Advanced Studies (STIAS) to provide DT the leisure
  and freedom to write up the first version of this perspective. Thanks also to three
  reviewers who have helped to improve the manuscript. Two dedicated symposia on the
  topic were funded by the Max-Planck Society.
article_number: iyag024
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Diethard
  full_name: Tautz, Diethard
  last_name: Tautz
- first_name: Luisa F
  full_name: Pallares, Luisa F
  last_name: Pallares
- first_name: Leif
  full_name: Andersson, Leif
  last_name: Andersson
- first_name: Neda
  full_name: Barghi, Neda
  last_name: Barghi
- first_name: Nicholas H
  full_name: Barton, Nicholas H
  id: 4880FE40-F248-11E8-B48F-1D18A9856A87
  last_name: Barton
  orcid: 0000-0002-8548-5240
- first_name: Rachael
  full_name: Bay, Rachael
  last_name: Bay
- first_name: Yingguang Frank
  full_name: Chan, Yingguang Frank
  last_name: Chan
- first_name: Angela
  full_name: Hancock, Angela
  last_name: Hancock
- first_name: Tobias S
  full_name: Kaiser, Tobias S
  last_name: Kaiser
- first_name: Daniel
  full_name: Koenig, Daniel
  last_name: Koenig
- first_name: Zacharias
  full_name: Kontarakis, Zacharias
  last_name: Kontarakis
- first_name: Miriam
  full_name: Liedvogel, Miriam
  last_name: Liedvogel
- first_name: Juliette
  full_name: de Meaux, Juliette
  last_name: de Meaux
- first_name: Magnus
  full_name: Nordborg, Magnus
  last_name: Nordborg
- first_name: Abraham A
  full_name: Palmer, Abraham A
  last_name: Palmer
- first_name: Michael
  full_name: Purugganan, Michael
  last_name: Purugganan
- first_name: Christian
  full_name: Schlötterer, Christian
  last_name: Schlötterer
- first_name: Karl
  full_name: Schmid, Karl
  last_name: Schmid
- first_name: Didier Y R
  full_name: Stainier, Didier Y R
  last_name: Stainier
- first_name: Detlef
  full_name: Weigel, Detlef
  last_name: Weigel
- first_name: Jochen B W
  full_name: Wolf, Jochen B W
  last_name: Wolf
- first_name: Dieter
  full_name: Ebert, Dieter
  last_name: Ebert
- first_name: Greg
  full_name: Gibson, Greg
  last_name: Gibson
citation:
  ama: 'Tautz D, Pallares LF, Andersson L, et al. Beyond Mendel: A call to revisit
    the genotype–phenotype map through new experimental paradigms. <i>Genetics</i>.
    2026;232(4). doi:<a href="https://doi.org/10.1093/genetics/iyag024">10.1093/genetics/iyag024</a>'
  apa: 'Tautz, D., Pallares, L. F., Andersson, L., Barghi, N., Barton, N. H., Bay,
    R., … Gibson, G. (2026). Beyond Mendel: A call to revisit the genotype–phenotype
    map through new experimental paradigms. <i>Genetics</i>. Oxford University Press.
    <a href="https://doi.org/10.1093/genetics/iyag024">https://doi.org/10.1093/genetics/iyag024</a>'
  chicago: 'Tautz, Diethard, Luisa F Pallares, Leif Andersson, Neda Barghi, Nicholas
    H Barton, Rachael Bay, Yingguang Frank Chan, et al. “Beyond Mendel: A Call to
    Revisit the Genotype–Phenotype Map through New Experimental Paradigms.” <i>Genetics</i>.
    Oxford University Press, 2026. <a href="https://doi.org/10.1093/genetics/iyag024">https://doi.org/10.1093/genetics/iyag024</a>.'
  ieee: 'D. Tautz <i>et al.</i>, “Beyond Mendel: A call to revisit the genotype–phenotype
    map through new experimental paradigms,” <i>Genetics</i>, vol. 232, no. 4. Oxford
    University Press, 2026.'
  ista: 'Tautz D, Pallares LF, Andersson L, Barghi N, Barton NH, Bay R, Chan YF, Hancock
    A, Kaiser TS, Koenig D, Kontarakis Z, Liedvogel M, de Meaux J, Nordborg M, Palmer
    AA, Purugganan M, Schlötterer C, Schmid K, Stainier DYR, Weigel D, Wolf JBW, Ebert
    D, Gibson G. 2026. Beyond Mendel: A call to revisit the genotype–phenotype map
    through new experimental paradigms. Genetics. 232(4), iyag024.'
  mla: 'Tautz, Diethard, et al. “Beyond Mendel: A Call to Revisit the Genotype–Phenotype
    Map through New Experimental Paradigms.” <i>Genetics</i>, vol. 232, no. 4, iyag024,
    Oxford University Press, 2026, doi:<a href="https://doi.org/10.1093/genetics/iyag024">10.1093/genetics/iyag024</a>.'
  short: D. Tautz, L.F. Pallares, L. Andersson, N. Barghi, N.H. Barton, R. Bay, Y.F.
    Chan, A. Hancock, T.S. Kaiser, D. Koenig, Z. Kontarakis, M. Liedvogel, J. de Meaux,
    M. Nordborg, A.A. Palmer, M. Purugganan, C. Schlötterer, K. Schmid, D.Y.R. Stainier,
    D. Weigel, J.B.W. Wolf, D. Ebert, G. Gibson, Genetics 232 (2026).
date_created: 2026-05-07T08:53:40Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-05-18T07:51:26Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1093/genetics/iyag024
external_id:
  pmid:
  - '41701356'
file:
- access_level: open_access
  checksum: 5a862c539f9dec4511277ad8927c549c
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-18T07:48:45Z
  date_updated: 2026-05-18T07:48:45Z
  file_id: '21890'
  file_name: 2026_Genetics_Tautz.pdf
  file_size: 542844
  relation: main_file
  success: 1
file_date_updated: 2026-05-18T07:48:45Z
has_accepted_license: '1'
intvolume: '       232'
issue: '4'
keyword:
- classic genetics
- quantitative genetics
- genotype–phenotype map
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
publication: Genetics
publication_identifier:
  eissn:
  - 1943-2631
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Beyond Mendel: A call to revisit the genotype–phenotype map through new experimental
  paradigms'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 232
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21842'
abstract:
- lang: eng
  text: "AM CVn stars are ultra-compact semi-detached binaries consisting of a white
    dwarf primary and a hydrogen-depleted secondary. In this\r\npaper, we present
    spectroscopic and photometric results of 15 transient sources pre-classified as
    AM CVn candidates. Our analysis confirms\r\n9 systems of the type AM CVn, 3 hydrogen-rich
    cataclysmic variables (accreting white dwarfs with near-main-sequence stars for
    donors),\r\nand 3 systems that could be evolved cataclysmic variables. Eight of
    the AM CVn stars are analysed spectroscopically for the first time,\r\nwhich increases
    the number of spectroscopically confirmed AM CVns by about 10%. TESS data revealed
    the orbital period of the AM CVn\r\nstar ASASSN-20pv to be Porb =27.282 min, which
    helps to constrain the possible values of its mass ratio. TESS also helped to
    determine\r\nthe superhump periods of one AM CVn star (ASASSN-19ct, Psh =30.94
    min) and two cataclysmic variables we classify as WZ Sge stars\r\n(Psh =90.77
    min for ZTF18aaaasnn and Psh =91.6min for ASASSN-15na).We identified very different
    abundances in the spectra of theAM\r\nCVns binaries ASASSN-15kf and ASASSN-20pv
    (both Porb ∼27.5min), suggesting different type of donors. Six of the studied
    AMCVns are\r\nX-ray sources, which helped to determine their mass accretion rates.
    Photometry shows that the duration of all the superoutbursts detected\r\nin the
    AM CVns is consistent with expectations from the disc instability model. Finally,
    we provide refined criteria for the identification of\r\nnew systems using all-sky
    surveys such as LSST."
acknowledgement: "We are grateful to the anonymous referee for providing\r\nus with
  useful comments and suggestions that improved our manuscript.\r\nJK and LRS acknowledge
  support from NASA grants NNH22ZDA001N-6152\r\nand 80NSSC24K0638. MPM is partially
  supported by the Swiss National\r\nScience Foundation IZSTZ0_216537 and by UNAM
  PAPIIT-IG101224. Based\r\non observations obtained at the international Gemini Observatory,
  a program\r\nof NSF NOIRLab, which is managed by the Association of Universities
  for\r\nResearch in Astronomy (AURA) under a cooperative agreement with the U.S.\r\nNational
  Science Foundation on behalf of the Gemini Observatory partnership:\r\nthe U.S.
  National Science Foundation (United States), National Research\r\nCouncil (Canada),
  Agencia Nacional de Investigación y Desarrollo (Chile), Ministerio de Ciencia, Tecnología
  e Innovación (Argentina), Ministério\r\nda Ciência, Tecnologia, Inovações e Comunicações
  (Brazil), and Korea\r\nAstronomy and Space Science Institute (Republic of Korea).
  The Gemini\r\ndata were obtained from programs GN-2023B-Q-310 and GS-2024A-Q-311\r\n(PI:
  Rivera Sandoval) and processed using DRAGONS (Data Reduction for\r\nAstronomy from
  Gemini Observatory North and South) The Digitized Sky\r\nSurveys were produced at
  the Space Telescope Science Institute under U.S.\r\nGovernment grant NAG W-2166.
  The images of these surveys are based on\r\nphotographic data obtained using the
  Oschin Schmidt Telescope on Palomar\r\nMountain and the UK Schmidt Telescope. The
  plates were processed into the\r\npresent compressed digital form with the permission
  of these institutions.\r\nThe National Geographic Society – Palomar Observatory
  Sky Atlas (POSS-I)\r\nwas made by the California Institute of Technology with grants
  from the\r\nNational Geographic Society. The Second Palomar Observatory Sky Survey\r\n(POSS-II)
  was made by the California Institute of Technology with funds\r\nfrom the National
  Science Foundation, the National Geographic Society, the\r\nSloan Foundation, the
  Samuel Oschin Foundation, and the Eastman Kodak\r\nCorporation. The Oschin Schmidt
  Telescope is operated by the California\r\nInstitute of Technology and Palomar Observatory.
  The UK Schmidt Telescope\r\nwas operated by the Royal Observatory Edinburgh, with
  funding from the\r\nUK Science and Engineering Research Council (later the UK Particle
  Physics\r\nand Astronomy Research Council), until 1988 June, and thereafter by the\r\nAnglo-Australian
  Observatory. The blue plates of the southern Sky Atlas\r\nand its Equatorial Extension
  (together known as the SERC-J), as well as the\r\nEquatorial Red (ER), and the Second
  Epoch [red] Survey (SES) were all taken\r\nwith the UK Schmidt. Supplemental funding
  for sky-survey work at the ST\r\nScI is provided by the European Southern Observatory.
  Based on observations\r\nobtained with the Samuel Oschin Telescope 48-inch and the
  60-inch Telescope\r\nat the Palomar Observatory as part of the Zwicky Transient
  Facility project.\r\nZTF is supported by the National Science Foundation under Grants
  No. AST-\r\n1440341 and AST-2034437 and a collaboration including current partners\r\nCaltech,
  IPAC, the Oskar Klein Center at Stockholm University, the University\r\nof Maryland,
  University of California, Berkeley, the University of Wisconsin\r\nat Milwaukee,
  University of Warwick, Ruhr University, Cornell University,\r\nNorthwestern University,
  and Drexel University. Operations are conducted\r\nby COO, IPAC, and UW. This work
  has used data from the European\r\nSpace Agency (ESA) mission Gaia (https://www.cosmos.esa.int/gaia),\r\nprocessed
  by the Gaia Data Processing and Analysis Consortium (DPAC,\r\nhttps://www.cosmos.esa.int/web/gaia/dpac/consortium).
  Funding for the\r\nDPAC has been provided by national institutions, in particular,
  the institutions\r\nparticipating in the Gaia Multilateral Agreement. We acknowledge
  with\r\nthanks the variable star observations from the AAVSO International Database\r\ncontributed
  by observers worldwide and used in this research. This paper\r\nincludes data collected
  by the TESS mission. Funding for the TESS mission\r\nis provided by the NASA Science
  Mission Directorate. Some of the data\r\npresented in this paper were obtained from
  the B. Mikulski Archive for Space\r\nTelescopes (MAST). This research has made use
  of the SIMBAD database,\r\noperated at CDS, Strasbourg, France. This research has
  made use of ‘Aladin\r\nsky atlas’ developed at CDS, Strasbourg Observatory, France.
  This research\r\nhas made use of the VizieR catalogue access tool, CDS, Strasbourg,
  France."
article_number: e052
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jan
  full_name: Kára, Jan
  last_name: Kára
- first_name: Liliana
  full_name: Rivera Sandoval, Liliana
  last_name: Rivera Sandoval
- first_name: Wendy
  full_name: Mendoza, Wendy
  last_name: Mendoza
- first_name: Thomas
  full_name: Maccarone, Thomas
  last_name: Maccarone
- first_name: Manuel
  full_name: Pichardo Marcano, Manuel
  last_name: Pichardo Marcano
- first_name: Luis E.
  full_name: Salazar Manzano, Luis E.
  last_name: Salazar Manzano
- first_name: Ryan J.
  full_name: Oelkers, Ryan J.
  last_name: Oelkers
- first_name: Joannes C
  full_name: van Roestel, Joannes C
  id: 4d122fc8-6083-11f0-87a5-97d68b860333
  last_name: van Roestel
citation:
  ama: Kára J, Rivera Sandoval L, Mendoza W, et al. A study of transients from ground-based
    surveys reveals new ultra-compact accreting white dwarf binaries. <i>Publications
    of the Astronomical Society of Australia</i>. 2026;43. doi:<a href="https://doi.org/10.1017/pasa.2026.10184">10.1017/pasa.2026.10184</a>
  apa: Kára, J., Rivera Sandoval, L., Mendoza, W., Maccarone, T., Pichardo Marcano,
    M., Salazar Manzano, L. E., … van Roestel, J. C. (2026). A study of transients
    from ground-based surveys reveals new ultra-compact accreting white dwarf binaries.
    <i>Publications of the Astronomical Society of Australia</i>. Cambridge University
    Press. <a href="https://doi.org/10.1017/pasa.2026.10184">https://doi.org/10.1017/pasa.2026.10184</a>
  chicago: Kára, Jan, Liliana Rivera Sandoval, Wendy Mendoza, Thomas Maccarone, Manuel
    Pichardo Marcano, Luis E. Salazar Manzano, Ryan J. Oelkers, and Joannes C van
    Roestel. “A Study of Transients from Ground-Based Surveys Reveals New Ultra-Compact
    Accreting White Dwarf Binaries.” <i>Publications of the Astronomical Society of
    Australia</i>. Cambridge University Press, 2026. <a href="https://doi.org/10.1017/pasa.2026.10184">https://doi.org/10.1017/pasa.2026.10184</a>.
  ieee: J. Kára <i>et al.</i>, “A study of transients from ground-based surveys reveals
    new ultra-compact accreting white dwarf binaries,” <i>Publications of the Astronomical
    Society of Australia</i>, vol. 43. Cambridge University Press, 2026.
  ista: Kára J, Rivera Sandoval L, Mendoza W, Maccarone T, Pichardo Marcano M, Salazar
    Manzano LE, Oelkers RJ, van Roestel JC. 2026. A study of transients from ground-based
    surveys reveals new ultra-compact accreting white dwarf binaries. Publications
    of the Astronomical Society of Australia. 43, e052.
  mla: Kára, Jan, et al. “A Study of Transients from Ground-Based Surveys Reveals
    New Ultra-Compact Accreting White Dwarf Binaries.” <i>Publications of the Astronomical
    Society of Australia</i>, vol. 43, e052, Cambridge University Press, 2026, doi:<a
    href="https://doi.org/10.1017/pasa.2026.10184">10.1017/pasa.2026.10184</a>.
  short: J. Kára, L. Rivera Sandoval, W. Mendoza, T. Maccarone, M. Pichardo Marcano,
    L.E. Salazar Manzano, R.J. Oelkers, J.C. van Roestel, Publications of the Astronomical
    Society of Australia 43 (2026).
date_created: 2026-05-07T08:55:00Z
date_published: 2026-03-27T00:00:00Z
date_updated: 2026-05-12T06:57:40Z
day: '27'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.1017/pasa.2026.10184
file:
- access_level: open_access
  checksum: f8f3cd3765948e8b276176c71c9d4e02
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-12T06:54:10Z
  date_updated: 2026-05-12T06:54:10Z
  file_id: '21862'
  file_name: 2026_PublAstronomicalSocAustralia_Kara.pdf
  file_size: 3681016
  relation: main_file
  success: 1
file_date_updated: 2026-05-12T06:54:10Z
has_accepted_license: '1'
intvolume: '        43'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Publications of the Astronomical Society of Australia
publication_identifier:
  eissn:
  - 1448-6083
  issn:
  - 1323-3580
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: A study of transients from ground-based surveys reveals new ultra-compact accreting
  white dwarf binaries
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21844'
abstract:
- lang: eng
  text: Little red dots (LRDs) are a newly identified class of broad-line active galactic
    nuclei (AGNs) with a distinctive V-shaped spectrum characterized by red optical
    and blue UV continuum emission. Their high abundance at redshifts of z ∼ 6–8 and
    decline at lower redshifts suggest a transient origin. We propose that the spectral
    shape of LRDs originates from compact binary black hole systems, in which each
    black hole is surrounded by a mini-disk and embedded within a larger circumbinary
    disk. With a binary separation of ≲103 Schwarzschild radii, the Wien tail of a
    T ≃ 5000 K blackbody spectrum at the inner edge of the circumbinary disk produces
    the red optical emission, while the mini-disks power the UV continuum. Binary
    torques carve out a gap between the circumbinary disk and the mini-disks, setting
    the turnover wavelength of the V-shaped spectrum around the Balmer limit. This
    scenario naturally reproduces LRD spectra requiring only modest dust attenuation
    (AV ≲ 1 mag), resolving overestimated luminosities for LRDs in previous studies
    and alleviating a tension with the so-called Sołtan argument. This model predicts
    distinct spectral evolution as the binary orbit decays through binary disk interactions
    and gravitational-wave (GW) emission, linking early-stage “proto-LRD” binaries
    to the broader AGN population and late-stage “LRD descendants” to coalescing binaries
    detectable in GW experiments.
acknowledgement: We greatly thank Kenta Hotokezaka and Hanpu Liu for constructive
  discussions. K.I., J.S., X.C., and L.C.H. acknowledge support from National Natural
  Science Foundation of China (grant Nos. 12573015, 1251101148, 12233001, and 12473037),
  the Beijing Natural Science Foundation (grant No. IS25003), and the China Manned
  Space Program (grant No. CMS-CSST-2025-A09). J.S. is also supported by “The Fundamental
  Research Funds for the Central Universities, Peking University” (grant No. 7100604896).
  Z.H. acknowledges support by US NSF grant AST-2006176 and by NASA grant Nos. 80NSSC24K0440
  and 80NSSC22K0822.
article_number: '25'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Kohei
  full_name: Inayoshi, Kohei
  last_name: Inayoshi
- first_name: Jinyi
  full_name: Shangguan, Jinyi
  last_name: Shangguan
- first_name: Xian
  full_name: Chen, Xian
  last_name: Chen
- first_name: Luis C.
  full_name: Ho, Luis C.
  last_name: Ho
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
  orcid: 0000-0003-3633-5403
citation:
  ama: Inayoshi K, Shangguan J, Chen X, Ho LC, Haiman Z. The emergence of Little Red
    Dots from binary massive black holes. <i>The Astrophysical Journal</i>. 2026;1002(1).
    doi:<a href="https://doi.org/10.3847/1538-4357/ae548d">10.3847/1538-4357/ae548d</a>
  apa: Inayoshi, K., Shangguan, J., Chen, X., Ho, L. C., &#38; Haiman, Z. (2026).
    The emergence of Little Red Dots from binary massive black holes. <i>The Astrophysical
    Journal</i>. IOP Publishing. <a href="https://doi.org/10.3847/1538-4357/ae548d">https://doi.org/10.3847/1538-4357/ae548d</a>
  chicago: Inayoshi, Kohei, Jinyi Shangguan, Xian Chen, Luis C. Ho, and Zoltán Haiman.
    “The Emergence of Little Red Dots from Binary Massive Black Holes.” <i>The Astrophysical
    Journal</i>. IOP Publishing, 2026. <a href="https://doi.org/10.3847/1538-4357/ae548d">https://doi.org/10.3847/1538-4357/ae548d</a>.
  ieee: K. Inayoshi, J. Shangguan, X. Chen, L. C. Ho, and Z. Haiman, “The emergence
    of Little Red Dots from binary massive black holes,” <i>The Astrophysical Journal</i>,
    vol. 1002, no. 1. IOP Publishing, 2026.
  ista: Inayoshi K, Shangguan J, Chen X, Ho LC, Haiman Z. 2026. The emergence of Little
    Red Dots from binary massive black holes. The Astrophysical Journal. 1002(1),
    25.
  mla: Inayoshi, Kohei, et al. “The Emergence of Little Red Dots from Binary Massive
    Black Holes.” <i>The Astrophysical Journal</i>, vol. 1002, no. 1, 25, IOP Publishing,
    2026, doi:<a href="https://doi.org/10.3847/1538-4357/ae548d">10.3847/1538-4357/ae548d</a>.
  short: K. Inayoshi, J. Shangguan, X. Chen, L.C. Ho, Z. Haiman, The Astrophysical
    Journal 1002 (2026).
date_created: 2026-05-10T22:02:14Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-11T07:09:12Z
day: '01'
ddc:
- '520'
department:
- _id: ZoHa
doi: 10.3847/1538-4357/ae548d
external_id:
  arxiv:
  - '2505.05322'
file:
- access_level: open_access
  checksum: b4506dfef3dd6da335775071d8f2a0a6
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-11T07:07:22Z
  date_updated: 2026-05-11T07:07:22Z
  file_id: '21853'
  file_name: 2026_AstrophysicalJour_Inayoshi.pdf
  file_size: 3041897
  relation: main_file
  success: 1
file_date_updated: 2026-05-11T07:07:22Z
has_accepted_license: '1'
intvolume: '      1002'
issue: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: The emergence of Little Red Dots from binary massive black holes
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1002
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21845'
abstract:
- lang: eng
  text: UTe2 exhibits the remarkable phenomenon of re-entrant superconductivity, whereby
    the zero-resistance state reappears above 40 tesla after being suppressed with
    a field of around 10 tesla. One potential pairing mechanism, invoked in the related
    re-entrant superconductors UCoGe and URhGe, involves transverse fluctuations of
    a ferromagnetic order parameter. However, the requisite ferromagnetic order—present
    in both UCoGe and URhGe—is absent in UTe2, and neutron scattering shows instead
    that the magnetic susceptibility is peaked at an antiferromagnetic wavevector.
    Here, we measure the magnetotropic susceptibility of UTe2 across two field-angle
    planes. This quantity is sensitive to the magnetic susceptibility in a direction
    transverse to the applied magnetic field—a quantity that is not accessed in conventional
    magnetization measurements. We observe a very large decrease in the magnetotropic
    susceptibility over a broad range of field orientations, indicating a large increase
    in the transverse magnetic susceptibility. Because our technique probes the magnetic
    susceptibility in the long wavelength (q = 0) limit, this suggests that the strong
    transverse susceptibility arises from ferromagnetic spin fluctuations. These ferromagnetic
    fluctuations are likely important for understanding the pairing mechanism in UTe2,
    as all three superconducting phases of UTe2 surround this region of enhanced susceptibility
    in the field-angle phase diagram.
acknowledged_ssus:
- _id: NanoFab
acknowledgement: We appreciate technical support from Salvatore Bagiante, Evgeniia
  Volobueva, Lubuna Shafeek, Ali Bangura, and Zoltán Köllö, and scientific discussions
  with Daniel Agterberg, Johnpierre Paglione, Qimiao Si, Josephine Yu and Yue Yu.
  V.Z., A.N., M.N., and K.A.M. acknowledge funding received from the European Research
  Council (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (TROPIC-101078696). V.Z., A.N., M.N., and K.A.M. thank the ISTA Nanofabrication
  Facility for technical support. B.J.R. acknowledges funding from the Office of Basic
  Energy Sciences of the United States Department of Energy under award number DE-SC0020143
  for data analysis and writing. The National High Magnetic Field Laboratory is supported
  by the National Science Foundation through NSF/DMR-2128556*, the State of Florida,
  and the U.S. Department of Energy. A.S. acknowledges support from the DOE/BES “Science
  of 100 T” grant. A.S. thanks Downtown Subscription in Santa Fe, NM, for their patience
  in hosting him. Sample preparation and characterization were supported by the NSF
  through DMR-2105191.
article_number: '3742'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Valeska
  full_name: Zambra, Valeska
  id: 467ed36b-dc96-11ea-b7c8-b043a380b282
  last_name: Zambra
  orcid: 0000-0002-8806-5719
- first_name: Amit
  full_name: Nathwani, Amit
  id: 1a362536-4d02-11f1-8543-8351136efc50
  last_name: Nathwani
- first_name: Muhammad
  full_name: Nauman, Muhammad
  id: 32c21954-2022-11eb-9d5f-af9f93c24e71
  last_name: Nauman
  orcid: 0000-0002-2111-4846
- first_name: Sylvia K.
  full_name: Lewin, Sylvia K.
  last_name: Lewin
- first_name: Corey E.
  full_name: Frank, Corey E.
  last_name: Frank
- first_name: Nicholas P.
  full_name: Butch, Nicholas P.
  last_name: Butch
- first_name: Arkady
  full_name: Shekhter, Arkady
  last_name: Shekhter
- first_name: B. J.
  full_name: Ramshaw, B. J.
  last_name: Ramshaw
- first_name: Kimberly A
  full_name: Modic, Kimberly A
  id: 13C26AC0-EB69-11E9-87C6-5F3BE6697425
  last_name: Modic
  orcid: 0000-0001-9760-3147
citation:
  ama: Zambra V, Nathwani A, Nauman M, et al. Giant transverse magnetic fluctuations
    at the edge of re-entrant superconductivity in UTe2. <i>Nature Communications</i>.
    2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-71899-7">10.1038/s41467-026-71899-7</a>
  apa: Zambra, V., Nathwani, A., Nauman, M., Lewin, S. K., Frank, C. E., Butch, N.
    P., … Modic, K. A. (2026). Giant transverse magnetic fluctuations at the edge
    of re-entrant superconductivity in UTe2. <i>Nature Communications</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s41467-026-71899-7">https://doi.org/10.1038/s41467-026-71899-7</a>
  chicago: Zambra, Valeska, Amit Nathwani, Muhammad Nauman, Sylvia K. Lewin, Corey
    E. Frank, Nicholas P. Butch, Arkady Shekhter, B. J. Ramshaw, and Kimberly A Modic.
    “Giant Transverse Magnetic Fluctuations at the Edge of Re-Entrant Superconductivity
    in UTe2.” <i>Nature Communications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-71899-7">https://doi.org/10.1038/s41467-026-71899-7</a>.
  ieee: V. Zambra <i>et al.</i>, “Giant transverse magnetic fluctuations at the edge
    of re-entrant superconductivity in UTe2,” <i>Nature Communications</i>, vol. 17.
    Springer Nature, 2026.
  ista: Zambra V, Nathwani A, Nauman M, Lewin SK, Frank CE, Butch NP, Shekhter A,
    Ramshaw BJ, Modic KA. 2026. Giant transverse magnetic fluctuations at the edge
    of re-entrant superconductivity in UTe2. Nature Communications. 17, 3742.
  mla: Zambra, Valeska, et al. “Giant Transverse Magnetic Fluctuations at the Edge
    of Re-Entrant Superconductivity in UTe2.” <i>Nature Communications</i>, vol. 17,
    3742, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-71899-7">10.1038/s41467-026-71899-7</a>.
  short: V. Zambra, A. Nathwani, M. Nauman, S.K. Lewin, C.E. Frank, N.P. Butch, A.
    Shekhter, B.J. Ramshaw, K.A. Modic, Nature Communications 17 (2026).
corr_author: '1'
date_created: 2026-05-10T22:02:15Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-11T06:36:00Z
day: '29'
ddc:
- '530'
department:
- _id: KiMo
- _id: GradSch
doi: 10.1038/s41467-026-71899-7
external_id:
  arxiv:
  - '2506.08984'
file:
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  checksum: 8cb95b033ad2a1a7a8181f6f078c05b5
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  creator: dernst
  date_created: 2026-05-11T06:32:12Z
  date_updated: 2026-05-11T06:32:12Z
  file_id: '21850'
  file_name: 2026_NatureComm_Zambra.pdf
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  success: 1
file_date_updated: 2026-05-11T06:32:12Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd968c70-d553-11ed-ba76-cde40b0aba64
  grant_number: '101078696'
  name: Gaining leverage with spin liquids and superconductors
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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    status: public
scopus_import: '1'
status: public
title: Giant transverse magnetic fluctuations at the edge of re-entrant superconductivity
  in UTe2
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21846'
abstract:
- lang: eng
  text: 'We compile a sample of 83 little red dots (LRDs) with JWST imaging and find
    that a substantial fraction (∼43%, rising to ≳80% for the most luminous LRDs)
    host one or more spatially offset, UV-bright companions at projected separations
    of 0.5 kpc ≲ d ≲ 5 kpc, with median 〈d〉 = 1.0 kpc. This fraction is even higher
    when smaller spatial scales are probed at high signal-to-noise ratio: the two
    most strongly lensed LRDs, A383-LRD1 and the newly discovered A68-LRD1, both have
    UV-bright companions at separations of only d ∼ 0.3 kpc, below the resolution
    limit of most unlensed JWST samples. We explore whether these ubiquitous red/blue
    configurations may be physically linked to the formation of LRDs, in analogy with
    the “synchronized pair” scenario originally proposed for direct-collapse black
    hole formation. In this picture, UV radiation from the companions, with typically
    modest stellar masses (M∗ ∼ 108−109 M⊙), suppresses molecular hydrogen cooling
    in nearby gas, allowing nearly isothermal collapse and the formation of extremely
    compact objects, such as massive black holes, supermassive stars, or quasi-stars.
    Using component-resolved photometry and spectral energy distribution modeling,
    we infer Lyman–Werner radiation fields of J21,LW ∼ 102.5–105 at the locations
    of the red components, comparable to those required in direct-collapse models,
    suggesting that the necessary photodissociation conditions are realized in many
    LRD systems. This framework provides a simple and self-consistent explanation
    for the extreme compactness and distinctive spectral properties of LRDs and links
    long-standing theoretical models for early compact object formation directly to
    a population now observed with JWST in the early Universe.'
acknowledgement: 'We thank Earl Bellinger, Fabio Pacucci, Andrea Ferrara, and Dale
  Kocevski for useful discussions. This work is based on observations made with the
  NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski
  Archive for Space Telescopes at the Space Telescope Science Institute, which is
  operated by the Association of Universities for Research in Astronomy, Inc., under
  NASA contract NAS 5-03127 for JWST. These imaging observations are associated with
  programs 1345, 1180, 1181, 1243, 6882, 2561, 1324, 4111, and 1895. The compiled
  dataset can be accessed at doi:10.17909/1m8f-9c47. The Cosmic Dawn Center (DAWN)
  is funded by the Danish National Research Foundation under grant DNRF140. J.M. and
  A.T. acknowledge funding by the European Union (ERC, AGENTS, 101076224). This work
  was performed in part at Aspen Center for Physics, which is supported by National
  Science Foundation grant PHY-2210452. This work used the following Python packages:
  Matplotlib (J. D. Hunter 2007), SciPy (P. Virtanen et al. 2020), NumPy (S. van der
  Walt et al. 2011), AstroPy (Astropy Collaboration et al. 2022), colossus (B. Diemer
  2018), and photutils (L. Bradley et al. 2025).'
article_number: L4
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Josephine F.W.
  full_name: Baggen, Josephine F.W.
  last_name: Baggen
- first_name: Matthew T.
  full_name: Scoggins, Matthew T.
  last_name: Scoggins
- first_name: Pieter
  full_name: Van Dokkum, Pieter
  last_name: Van Dokkum
- first_name: Zoltán
  full_name: Haiman, Zoltán
  id: 7c006e8c-cc0d-11ee-8322-cb904ef76f36
  last_name: Haiman
  orcid: 0000-0003-3633-5403
- first_name: Alberto
  full_name: Torralba Torregrosa, Alberto
  id: 018f0249-0e87-11f0-b167-cbce08fbd541
  last_name: Torralba Torregrosa
  orcid: 0000-0001-5586-6950
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
citation:
  ama: 'Baggen JFW, Scoggins MT, Van Dokkum P, Haiman Z, Torralba Torregrosa A, Matthee
    JJ. Connecting the dots: UV-bright companions of Little Red Dots as Lyman–Werner
    sources enabling direct-collapse Black Hole formation. <i>The Astrophysical Journal
    Letters</i>. 2026;1002(1). doi:<a href="https://doi.org/10.3847/2041-8213/ae58a5">10.3847/2041-8213/ae58a5</a>'
  apa: 'Baggen, J. F. W., Scoggins, M. T., Van Dokkum, P., Haiman, Z., Torralba Torregrosa,
    A., &#38; Matthee, J. J. (2026). Connecting the dots: UV-bright companions of
    Little Red Dots as Lyman–Werner sources enabling direct-collapse Black Hole formation.
    <i>The Astrophysical Journal Letters</i>. IOP Publishing. <a href="https://doi.org/10.3847/2041-8213/ae58a5">https://doi.org/10.3847/2041-8213/ae58a5</a>'
  chicago: 'Baggen, Josephine F.W., Matthew T. Scoggins, Pieter Van Dokkum, Zoltán
    Haiman, Alberto Torralba Torregrosa, and Jorryt J Matthee. “Connecting the Dots:
    UV-Bright Companions of Little Red Dots as Lyman–Werner Sources Enabling Direct-Collapse
    Black Hole Formation.” <i>The Astrophysical Journal Letters</i>. IOP Publishing,
    2026. <a href="https://doi.org/10.3847/2041-8213/ae58a5">https://doi.org/10.3847/2041-8213/ae58a5</a>.'
  ieee: 'J. F. W. Baggen, M. T. Scoggins, P. Van Dokkum, Z. Haiman, A. Torralba Torregrosa,
    and J. J. Matthee, “Connecting the dots: UV-bright companions of Little Red Dots
    as Lyman–Werner sources enabling direct-collapse Black Hole formation,” <i>The
    Astrophysical Journal Letters</i>, vol. 1002, no. 1. IOP Publishing, 2026.'
  ista: 'Baggen JFW, Scoggins MT, Van Dokkum P, Haiman Z, Torralba Torregrosa A, Matthee
    JJ. 2026. Connecting the dots: UV-bright companions of Little Red Dots as Lyman–Werner
    sources enabling direct-collapse Black Hole formation. The Astrophysical Journal
    Letters. 1002(1), L4.'
  mla: 'Baggen, Josephine F. W., et al. “Connecting the Dots: UV-Bright Companions
    of Little Red Dots as Lyman–Werner Sources Enabling Direct-Collapse Black Hole
    Formation.” <i>The Astrophysical Journal Letters</i>, vol. 1002, no. 1, L4, IOP
    Publishing, 2026, doi:<a href="https://doi.org/10.3847/2041-8213/ae58a5">10.3847/2041-8213/ae58a5</a>.'
  short: J.F.W. Baggen, M.T. Scoggins, P. Van Dokkum, Z. Haiman, A. Torralba Torregrosa,
    J.J. Matthee, The Astrophysical Journal Letters 1002 (2026).
date_created: 2026-05-10T22:02:15Z
date_published: 2026-04-10T00:00:00Z
date_updated: 2026-05-11T06:48:33Z
day: '10'
ddc:
- '520'
department:
- _id: ZoHa
- _id: JoMa
doi: 10.3847/2041-8213/ae58a5
external_id:
  arxiv:
  - '2602.02702'
file:
- access_level: open_access
  checksum: 8c31d8603cd6ad39c772a72d136dc3f8
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-11T06:44:37Z
  date_updated: 2026-05-11T06:44:37Z
  file_id: '21851'
  file_name: 2026_AstrophysicalJourLetters_Baggen.pdf
  file_size: 13359642
  relation: main_file
  success: 1
file_date_updated: 2026-05-11T06:44:37Z
has_accepted_license: '1'
intvolume: '      1002'
issue: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: bd9b2118-d553-11ed-ba76-db24564edfea
  grant_number: '101076224'
  name: Young galaxies as tracers and agents of cosmic reionization
publication: The Astrophysical Journal Letters
publication_identifier:
  eissn:
  - 2041-8213
  issn:
  - 2041-8205
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Connecting the dots: UV-bright companions of Little Red Dots as Lyman–Werner
  sources enabling direct-collapse Black Hole formation'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1002
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21847'
abstract:
- lang: eng
  text: Analog quantum simulators provide access to many-body dynamics beyond the
    reach of classical computation. However, extracting physical insights from experimental
    data is often hindered by measurement noise, limited observables, and incomplete
    knowledge of the underlying microscopic model. Here, we develop a machine learning
    approach based on a variational autoencoder (VAE) to analyze interference measurements
    of tunnel-coupled one-dimensional Bose gases, which realize the sine-Gordon quantum
    field theory. Trained in an unsupervised manner, the VAE learns a minimal latent
    representation that strongly correlates with the equilibrium control parameter
    of the system. Applied to nonequilibrium protocols, the latent space uncovers
    signatures of frozen-in solitons following rapid cooling, and reveals anomalous
    postquench dynamics not captured by conventional correlation-based methods. These
    results demonstrate that generative models can extract physically interpretable
    variables directly from noisy and sparse experimental data, providing complementary
    probes of equilibrium and nonequilibrium physics in quantum simulators. More broadly,
    our work highlights how machine learning can supplement established field-theoretical
    techniques, paving the way for scalable, data-driven discovery in quantum many-body
    systems.
acknowledgement: "We thank Sebastian Erne and Igor Mazets for helpful discussions
  and sharing codes for the transfer matrix sampling. This research was funded in
  part by the European Research Council: ERC Advanced Grant “Emergence in Quantum
  Physics” (EmQ) under Grant Agreement No. 101097858 and ERC Advanced Grant “Artificial
  agency and learning in quantum environments” (QuantAI) under Grant Agreement No.
  101055129. This work was also supported by the Austrian Science Fund (FWF) (SFB
  BeyondC F7102, 10.55776/F71). G.F.-F. acknowledges the European Research Council
  AdG NOQIA; MCIN/AEI [PGC2018-0910.13039/501100011033, CEX2019-000910-S/10.13039/501100011033,
  Plan National FIDEUA PID2019-106901GB-I00, Plan National STAMEENA PID2022-139099NB,
  I00, project funded by MCIN/AEI/10.13039/501100011033 and by the “European Union
  NextGenerationEU/PRTR” (PRTR-C17.I1), FPI]; QUANTERA DYNAMITE PCI2022-132919 under
  Grant Agreement No. 101017733; Ministry for Digital Transformation and of Civil
  Service of the Spanish Government through the QUANTUM ENIA project call—Quantum
  Spain project, and by the European Union through the Recovery, Transformation and
  Resilience Plan—NextGenerationEU within the framework of the Digital Spain 2026
  Agenda; Fundació Cellex; Fundació Mir-Puig; Generalitat de Catalunya (European Social
  Fund FEDER and CERCA program); Barcelona Supercomputing Center MareNostrum (FI-2023-3-0024);
  (HORIZON-CL4-2022-QUANTUM-02-SGA PASQuanS2.1, 101113690, EU Horizon 2020 FET-OPEN
  OPTOlogic, Grant No. 899794, QU-ATTO, 101168628), EU Horizon Europe Program (This
  project has received funding from the European Union's Horizon Europe research and
  innovation program under Grant Agreement No. 101080086 NeQST); ICFO Internal “QuantumGaudi”
  project. This research was funded in whole or in part by the Austrian Science Fund
  (FWF) [10.55776/COE1] through the Cluster of Excellence quantA (Quantum Science
  Austria).\r\n\r\nThe views and opinions expressed in this article are however those
  of the author(s) only and do not necessarily reflect those of the European Union
  or the European Research Council—neither the European Union nor the granting authority
  can be held responsible for them."
article_number: '023094'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Frederik Skovbo
  full_name: Moller, Frederik Skovbo
  id: 43cbcc83-0564-11f0-a935-e37325525859
  last_name: Moller
- first_name: Gabriel
  full_name: Fernández-Fernández, Gabriel
  last_name: Fernández-Fernández
- first_name: Thomas
  full_name: Schweigler, Thomas
  last_name: Schweigler
- first_name: Paulin
  full_name: De Schoulepnikoff, Paulin
  last_name: De Schoulepnikoff
- first_name: Jörg
  full_name: Schmiedmayer, Jörg
  last_name: Schmiedmayer
- first_name: Gorka
  full_name: Muñoz-Gil, Gorka
  last_name: Muñoz-Gil
citation:
  ama: Moller FS, Fernández-Fernández G, Schweigler T, De Schoulepnikoff P, Schmiedmayer
    J, Muñoz-Gil G. Learning minimal representations of many-body physics from snapshots
    of a quantum simulator. <i>Physical Review Research</i>. 2026;8(2). doi:<a href="https://doi.org/10.1103/r7pj-gl7r">10.1103/r7pj-gl7r</a>
  apa: Moller, F. S., Fernández-Fernández, G., Schweigler, T., De Schoulepnikoff,
    P., Schmiedmayer, J., &#38; Muñoz-Gil, G. (2026). Learning minimal representations
    of many-body physics from snapshots of a quantum simulator. <i>Physical Review
    Research</i>. American Physical Society. <a href="https://doi.org/10.1103/r7pj-gl7r">https://doi.org/10.1103/r7pj-gl7r</a>
  chicago: Moller, Frederik Skovbo, Gabriel Fernández-Fernández, Thomas Schweigler,
    Paulin De Schoulepnikoff, Jörg Schmiedmayer, and Gorka Muñoz-Gil. “Learning Minimal
    Representations of Many-Body Physics from Snapshots of a Quantum Simulator.” <i>Physical
    Review Research</i>. American Physical Society, 2026. <a href="https://doi.org/10.1103/r7pj-gl7r">https://doi.org/10.1103/r7pj-gl7r</a>.
  ieee: F. S. Moller, G. Fernández-Fernández, T. Schweigler, P. De Schoulepnikoff,
    J. Schmiedmayer, and G. Muñoz-Gil, “Learning minimal representations of many-body
    physics from snapshots of a quantum simulator,” <i>Physical Review Research</i>,
    vol. 8, no. 2. American Physical Society, 2026.
  ista: Moller FS, Fernández-Fernández G, Schweigler T, De Schoulepnikoff P, Schmiedmayer
    J, Muñoz-Gil G. 2026. Learning minimal representations of many-body physics from
    snapshots of a quantum simulator. Physical Review Research. 8(2), 023094.
  mla: Moller, Frederik Skovbo, et al. “Learning Minimal Representations of Many-Body
    Physics from Snapshots of a Quantum Simulator.” <i>Physical Review Research</i>,
    vol. 8, no. 2, 023094, American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/r7pj-gl7r">10.1103/r7pj-gl7r</a>.
  short: F.S. Moller, G. Fernández-Fernández, T. Schweigler, P. De Schoulepnikoff,
    J. Schmiedmayer, G. Muñoz-Gil, Physical Review Research 8 (2026).
date_created: 2026-05-10T22:02:15Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-11T06:58:56Z
day: '29'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1103/r7pj-gl7r
external_id:
  arxiv:
  - '2509.13821'
file:
- access_level: open_access
  checksum: dbfc58e1e176f7b63e0d274eb0d1bffa
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-11T06:56:58Z
  date_updated: 2026-05-11T06:56:58Z
  file_id: '21852'
  file_name: 2026_PhysicalReviewResearch_Moller.pdf
  file_size: 1829628
  relation: main_file
  success: 1
file_date_updated: 2026-05-11T06:56:58Z
has_accepted_license: '1'
intvolume: '         8'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Physical Review Research
publication_identifier:
  eissn:
  - 2643-1564
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Learning minimal representations of many-body physics from snapshots of a quantum
  simulator
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21848'
abstract:
- lang: eng
  text: 'Despite the success of mRNA therapeutics, challenges remain in optimizing
    immune responses and minimizing side effects. Cell-specific antigen delivery may
    help reduce required doses and improve vaccine efficacy. In this study, we report
    on a targeted delivery system for mRNA to a specific subset of skin-resident antigen-presenting
    cells: Langerhans cells. By functionalizing lipid nanoparticles with a langerin-specific
    glycomimetic ligand, we achieve selective mRNA delivery to both murine and human
    primary Langerhans cells with minimal off-target uptake, at the same time resulting
    in significantly increased mRNA translation. This targeted mRNA delivery not only
    enhances antigen presentation and T-cell responses but also enables dose-sparing
    and superior antitumor immunity compared with conventional immunization in a B16-OVA
    tumor model. Importantly, our platform’s high compatibility with various lipid
    nanoparticle formulations offers a flexible and precise tool for skin-directed
    mRNA delivery.'
acknowledged_ssus:
- _id: PreCl
acknowledgement: We thank Mareike Rentzsch for her intellectual contributions during
  the course of our discussions. We thank Michael Schunn from the Preclinical Facility
  of the Institute of Science and Technology Austria for his continuous technical
  support. Guarantor of the work is FS. This project was supported by “Seedfinancing”
  (P2282679) of the Austrian Federal Ministry of Digital and Economic Affairs and
  the Ministry of Climate Action and Energy, handled by the Austrian Wirtschaftsservice,
  as well as by...
article_processing_charge: No
article_type: original
author:
- first_name: Klara
  full_name: Klein, Klara
  last_name: Klein
- first_name: Litty
  full_name: Johnson, Litty
  last_name: Johnson
- first_name: Ramona
  full_name: Rîca, Ramona
  last_name: Rîca
- first_name: Mirza
  full_name: Sarcevic, Mirza
  last_name: Sarcevic
- first_name: Gabriele
  full_name: Carta, Gabriele
  last_name: Carta
- first_name: Saskia
  full_name: Seiser, Saskia
  last_name: Seiser
- first_name: Adelheid
  full_name: Elbe-Bürger, Adelheid
  last_name: Elbe-Bürger
- first_name: Freyja
  full_name: Langer, Freyja
  id: 3C1BE782-F248-11E8-B48F-1D18A9856A87
  last_name: Langer
- first_name: Nowras
  full_name: Rahhal, Nowras
  last_name: Rahhal
- first_name: Christoph
  full_name: Rademacher, Christoph
  last_name: Rademacher
- first_name: Robert
  full_name: Wawrzinek, Robert
  last_name: Wawrzinek
- first_name: Federica
  full_name: Quattrone, Federica
  last_name: Quattrone
- first_name: Florian
  full_name: Sparber, Florian
  last_name: Sparber
citation:
  ama: 'Klein K, Johnson L, Rîca R, et al. Langerhans cell–targeted mRNA delivery:
    A strategy for dose-sparing and enhanced antitumor immunity. <i>Journal of Investigative
    Dermatology</i>. doi:<a href="https://doi.org/10.1016/j.jid.2026.03.026">10.1016/j.jid.2026.03.026</a>'
  apa: 'Klein, K., Johnson, L., Rîca, R., Sarcevic, M., Carta, G., Seiser, S., … Sparber,
    F. (n.d.). Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing
    and enhanced antitumor immunity. <i>Journal of Investigative Dermatology</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.jid.2026.03.026">https://doi.org/10.1016/j.jid.2026.03.026</a>'
  chicago: 'Klein, Klara, Litty Johnson, Ramona Rîca, Mirza Sarcevic, Gabriele Carta,
    Saskia Seiser, Adelheid Elbe-Bürger, et al. “Langerhans Cell–Targeted MRNA Delivery:
    A Strategy for Dose-Sparing and Enhanced Antitumor Immunity.” <i>Journal of Investigative
    Dermatology</i>. Elsevier, n.d. <a href="https://doi.org/10.1016/j.jid.2026.03.026">https://doi.org/10.1016/j.jid.2026.03.026</a>.'
  ieee: 'K. Klein <i>et al.</i>, “Langerhans cell–targeted mRNA delivery: A strategy
    for dose-sparing and enhanced antitumor immunity,” <i>Journal of Investigative
    Dermatology</i>. Elsevier.'
  ista: 'Klein K, Johnson L, Rîca R, Sarcevic M, Carta G, Seiser S, Elbe-Bürger A,
    Langer F, Rahhal N, Rademacher C, Wawrzinek R, Quattrone F, Sparber F. Langerhans
    cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced antitumor
    immunity. Journal of Investigative Dermatology.'
  mla: 'Klein, Klara, et al. “Langerhans Cell–Targeted MRNA Delivery: A Strategy for
    Dose-Sparing and Enhanced Antitumor Immunity.” <i>Journal of Investigative Dermatology</i>,
    Elsevier, doi:<a href="https://doi.org/10.1016/j.jid.2026.03.026">10.1016/j.jid.2026.03.026</a>.'
  short: K. Klein, L. Johnson, R. Rîca, M. Sarcevic, G. Carta, S. Seiser, A. Elbe-Bürger,
    F. Langer, N. Rahhal, C. Rademacher, R. Wawrzinek, F. Quattrone, F. Sparber, Journal
    of Investigative Dermatology (n.d.).
date_created: 2026-05-10T22:02:16Z
date_published: 2026-04-07T00:00:00Z
date_updated: 2026-05-11T06:07:32Z
day: '07'
department:
- _id: PreCl
doi: 10.1016/j.jid.2026.03.026
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2025.06.25.661517
month: '04'
oa: 1
oa_version: Preprint
publication: Journal of Investigative Dermatology
publication_identifier:
  eissn:
  - 1523-1747
  issn:
  - 0022-202X
publication_status: inpress
publisher: Elsevier
scopus_import: '1'
status: public
title: 'Langerhans cell–targeted mRNA delivery: A strategy for dose-sparing and enhanced
  antitumor immunity'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21860'
abstract:
- lang: eng
  text: Glutamate excitotoxicity is a cell death mechanism triggered by accumulation
    of glutamate in the extracellular space. The α-ketoglutarate dehydrogenase complex
    (αKGDHC), an enzyme of the tricarboxylic acid cycle, represents a branching point
    controlling glutamate formation and its consumption as a fuel. Hence, modulation
    of the activity of αKGDHC might alter the amount of glutamate available for excitotoxic
    effects. To address this hypothesis, hippocampal neurons in primary co-culture
    with glial cells were exposed to zero-Mg2 buffer to elicit excitotoxicity through
    N-methyl-D-aspartic acid (NMDA) receptor disinhibition. Pretreatment of the cultures
    with succinyl phosphonate, to inhibit αKGDHC, enhanced excitotoxity, whereas promotion
    of αKGDHC activity by pretreatment with thiamine caused an opposite action. Moreover,
    NMDA receptor currents – but not those mediated by α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
    acid (AMPA) receptors – were potentiated in neurons with impaired αKGDHC activity
    and diminished in neurons with boosted αKGDHC activity. The sensitization of NMDA
    receptors involved mGluR1 activation and was accompanied by enhanced neuronal
    discharge activity, elevated basal cytosolic Ca2+ levels, and augmented Ca2+ responses
    evoked by glutamate application. These results suggest that mGluR1-mediated potentiation
    of NMDA receptors contributes to a mechanism by which inhibition of αKGDHC might
    exacerbate glutamate excitotoxicity.
acknowledgement: The technical assistance by Tanja Wagner and Elena Lilliu is gratefully
  acknowledged. This research was funded in whole or in part by the Austrian Science
  Fund (FWF) (P36145 to H.K., PAT8605623 to M.H. and P33799 to A.V.K.]. Open Access
  funding provided by Medical University of Vienna and the Austrian Science Fund (FWF).
  Deposited in PMC for immediate release.
article_number: jcs264420
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Vanessa
  full_name: Goeschl, Vanessa
  last_name: Goeschl
- first_name: Matej
  full_name: Hotka, Matej
  last_name: Hotka
- first_name: Bernhard
  full_name: Hochreiter, Bernhard
  id: e6cab3de-17f6-11ed-9210-c1e42e045e9d
  last_name: Hochreiter
- first_name: Karlheinz
  full_name: Hilber, Karlheinz
  last_name: Hilber
- first_name: Stefan
  full_name: Boehm, Stefan
  last_name: Boehm
- first_name: Andrey V.
  full_name: Kozlov, Andrey V.
  last_name: Kozlov
- first_name: Helmut
  full_name: Kubista, Helmut
  last_name: Kubista
citation:
  ama: Goeschl V, Hotka M, Hochreiter B, et al. α-ketoglutarate dehydrogenase complex
    activity modulates glutamate excitotoxicity via metabotropic regulation of NMDA
    receptors in primary cultures. <i>Journal of Cell Science</i>. 2026;139(8). doi:<a
    href="https://doi.org/10.1242/jcs.264420">10.1242/jcs.264420</a>
  apa: Goeschl, V., Hotka, M., Hochreiter, B., Hilber, K., Boehm, S., Kozlov, A. V.,
    &#38; Kubista, H. (2026). α-ketoglutarate dehydrogenase complex activity modulates
    glutamate excitotoxicity via metabotropic regulation of NMDA receptors in primary
    cultures. <i>Journal of Cell Science</i>. The Company of Biologists. <a href="https://doi.org/10.1242/jcs.264420">https://doi.org/10.1242/jcs.264420</a>
  chicago: Goeschl, Vanessa, Matej Hotka, Bernhard Hochreiter, Karlheinz Hilber, Stefan
    Boehm, Andrey V. Kozlov, and Helmut Kubista. “α-Ketoglutarate Dehydrogenase Complex
    Activity Modulates Glutamate Excitotoxicity via Metabotropic Regulation of NMDA
    Receptors in Primary Cultures.” <i>Journal of Cell Science</i>. The Company of
    Biologists, 2026. <a href="https://doi.org/10.1242/jcs.264420">https://doi.org/10.1242/jcs.264420</a>.
  ieee: V. Goeschl <i>et al.</i>, “α-ketoglutarate dehydrogenase complex activity
    modulates glutamate excitotoxicity via metabotropic regulation of NMDA receptors
    in primary cultures,” <i>Journal of Cell Science</i>, vol. 139, no. 8. The Company
    of Biologists, 2026.
  ista: Goeschl V, Hotka M, Hochreiter B, Hilber K, Boehm S, Kozlov AV, Kubista H.
    2026. α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity
    via metabotropic regulation of NMDA receptors in primary cultures. Journal of
    Cell Science. 139(8), jcs264420.
  mla: Goeschl, Vanessa, et al. “α-Ketoglutarate Dehydrogenase Complex Activity Modulates
    Glutamate Excitotoxicity via Metabotropic Regulation of NMDA Receptors in Primary
    Cultures.” <i>Journal of Cell Science</i>, vol. 139, no. 8, jcs264420, The Company
    of Biologists, 2026, doi:<a href="https://doi.org/10.1242/jcs.264420">10.1242/jcs.264420</a>.
  short: V. Goeschl, M. Hotka, B. Hochreiter, K. Hilber, S. Boehm, A.V. Kozlov, H.
    Kubista, Journal of Cell Science 139 (2026).
date_created: 2026-05-11T10:52:27Z
date_published: 2026-04-27T00:00:00Z
date_updated: 2026-05-12T06:40:18Z
day: '27'
ddc:
- '570'
department:
- _id: Bio
doi: 10.1242/jcs.264420
external_id:
  pmid:
  - '41834724'
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pmid: 1
publication: Journal of Cell Science
publication_identifier:
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publication_status: published
publisher: The Company of Biologists
quality_controlled: '1'
scopus_import: '1'
status: public
title: α-ketoglutarate dehydrogenase complex activity modulates glutamate excitotoxicity
  via metabotropic regulation of NMDA receptors in primary cultures
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
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  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 139
year: '2026'
...
---
OA_place: publisher
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abstract:
- lang: eng
  text: "Atoms and photons, two things so different but yet so alike. The former,
    the building block of matter, something we learn about in school and imagine it
    as some tiny marbles encircled by other tinier marbles. The latter, an electromagnetic
    wave, a light particle or an excitation of the electromagnetic field. Quantum
    mechanics tells us about the properties of these two entities. And even if it
    sounds, looks and writes counter-intuitive, it has proven right for over a century
    now.\r\n\r\nIn this work, I elaborate on how we tested the laws of quantum mechanics
    and how we used them learn more about the tiny building blocks of nature and the
    fields they use to talk to each other. The atoms we use, are artificial. Superconducting
    qubits, small electrical circuits with quantized energy levels behave like electrons
    that transition between different orbitals in an atom. One of the qubits' advantages,
    is also a big disadvantage. We design the circuits' energy levels and fabricate
    them in a cleanroom. This allows for arbitrary spaced energy levels but in contrast
    to real atoms, prevents two superconducting qubits from being alike. Still, this
    qubit platform is one of the frontrunners for future quantum computing technology
    and testing fundamental physics due to their scalability.\r\n\r\nWe interface
    superconducting qubits, which operate in the GHz regime, with microwave photons.
    We use 3D aluminum cavities as mediators between qubits and photons. The cavities
    allow for non-destructive readout of the qubit state, they shield the qubits from
    noise at the qubit frequency and they give us an easy way to frequency-tune these
    joint systems.\r\n\r\nWe need to operate superconducting qubits and their cavities
    at millikelvin temperatures in dilution refrigerators. At higher temperatures,
    superconductivity suffers and even worse, the environment is filled with thermal
    noise photons. This poses a fundamental limitation on the scalability of superconducting
    qubit devices. Also connecting multiple devices in different fridges does not
    work over room temperature links because the microwave photons used for this purpose
    will be covered in noise and the quantum information they carry, will be unusable.\r\n\r\nInfrared
    photons do not suffer from this noise problem since there are close to zero thermal
    noise photons at their frequencies at room temperature. We cannot simply interface
    superconducting devices with optical photons due their frequency mismatch and
    the destructive effect of optical photons on superconductors. Therefore, we use
    microwave-to-optics transducers that allow to convert microwave photons into optical
    ones and vice-versa. The transducers that we use are macroscopic electro-optic
    transducers using the Pockels effect in a disk-shaped Lithium Niobate whispering
    gallery mode resonator. By using a strong optical pump, photons from the two frequency
    domains experience a beam-splitter interaction and get converted from one to the
    other.\r\n\r\nWe measure the generated optical photons using elaborate optical
    setups, optical heterodyning and single photon detectors to gain knowledge about
    the qubit state or the converted microwave photons. Bridging the microwave and
    the optical world allows us to take advantage of both of their strengths but it
    also requires deep knowledge about both of their working principles.\r\n\r\nIn
    this work, we describe two experiments that our group conducted to showcase the
    opportunities that arise from interfacing superconducting qubits with optical
    photons but also the pitfalls, one may encounter on the way.\r\n\r\nIn the first
    experiment, we managed to all-optically read out a superconducting qubit. We show
    that the assignment fidelity, the probability that a measurement of the qubit
    state matches the prepared state, is close to equal for all-optical, microwave-to-optics
    and conventional microwave readout. We show T1 and T2 measurements for all three
    readout types and give an analysis of the noise caused by the optics. Finally,
    we show that the infrared light does not affect the qubit performance in a negative
    way but that the heating it causes does. This is an important insight that we
    used in the next experiment.\r\n\r\nThe second experiment is the upconversion
    of itinerant single microwave photons to the optical domain. We show that we can
    generate single microwave photons from a qubit-cavity system. We upconvert these
    single photons, measure them with a single photon detector and reconstruct their
    shape. By conducting a single photon Rabi measurement, we show correlations between
    the microwave and the optical domain. And by thorough signal-to-noise measurements
    and noise analysis, we find that we can generate single infrared photons with
    high signal-to-noise ratio 5.1 and low transducer added noise (<0.012 quanta).
    We show that this measurement creates a path towards entanglement of a superconducting
    qubit and an optical photon and what parameters need to be improved to achieve
    it. Additionally, this experiment is a proof of principle for an on-demand infrared
    single photon source. More generally, it allows to link microwave quantum technology
    in general to the optical domain."
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
- _id: LifeSc
- _id: SSU
acknowledgement: "The author of this work was supported by the European Research Council
  under grant no.\r\n101089099 (ERC CoG cQEO) and the European Union’s Horizon 2020
  research and innovation\r\nprogram under grant no. 899354 (FETopen SuperQuLAN).\r\nThis
  work was also supported by the European Research Council under grant nos. 758053\r\n(ERC
  StG QUNNECT), 101248662 (ERC POC CoupledEOT), and the European Innovation\r\nCouncil
  no. 101187231 (PathfinderOpen CIELO). This research was funded in whole or in part\r\nby
  the Austrian Science Fund (FWF) [10.55776/F71]. For open access purposes, the author\r\nhas
  applied a CC BY public copyright license to any author accepted manuscript version
  arising\r\nfrom this submission.\r\niii\r\nMy co-authors in the works mentioned
  later acknowledge generous support from the ISTFELLOW program, the NOMIS-ISTA fellowship,
  the Horizon Europe Program HORIZONCL4-2022-QUANTUM-01-SGA via Project No. 101113946
  OpenSuperQPlus100 and a DOC fellowship of the Austrian Academy of Sciences at IST
  Austria.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Thomas
  full_name: Werner, Thomas
  id: 1fcd8497-dba3-11ea-a45e-c6fbd715f7c7
  last_name: Werner
  orcid: 0009-0001-2346-5236
citation:
  ama: Werner T. Interfacing superconducting qubits with optical photons. 2026. doi:<a
    href="https://doi.org/10.15479/AT-ISTA-21863">10.15479/AT-ISTA-21863</a>
  apa: Werner, T. (2026). <i>Interfacing superconducting qubits with optical photons</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21863">https://doi.org/10.15479/AT-ISTA-21863</a>
  chicago: Werner, Thomas. “Interfacing Superconducting Qubits with Optical Photons.”
    Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21863">https://doi.org/10.15479/AT-ISTA-21863</a>.
  ieee: T. Werner, “Interfacing superconducting qubits with optical photons,” Institute
    of Science and Technology Austria, 2026.
  ista: Werner T. 2026. Interfacing superconducting qubits with optical photons. Institute
    of Science and Technology Austria.
  mla: Werner, Thomas. <i>Interfacing Superconducting Qubits with Optical Photons</i>.
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21863">10.15479/AT-ISTA-21863</a>.
  short: T. Werner, Interfacing Superconducting Qubits with Optical Photons, Institute
    of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-05-12T09:04:02Z
date_published: 2026-05-12T00:00:00Z
date_updated: 2026-05-20T13:35:43Z
day: '12'
ddc:
- '530'
- '537'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoFi
doi: 10.15479/AT-ISTA-21863
ec_funded: 1
file:
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  creator: twerner
  date_created: 2026-05-15T15:53:57Z
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file_date_updated: 2026-05-15T15:54:06Z
has_accepted_license: '1'
keyword:
- Superconducting qubits
- Quantum optics
- Single photons and quantum effects
- Nonlinear optics
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '97'
project:
- _id: bdadfa0d-d553-11ed-ba76-fb85edbd456a
  grant_number: '101089099'
  name: 'Cavity Quantum Electro Optics: Microwave photonics with nonclassical states'
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
  call_identifier: H2020
  grant_number: '899354'
  name: Quantum Local Area Networks with Superconducting Qubits
- _id: 26336814-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '758053'
  name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 5b807754-ab3d-11f0-914f-ff8c34502cc9
  grant_number: '101248662'
  name: Integrated optical coupling for low loss electro-optic interconnects
- _id: 91aaf765-16d5-11f0-9cad-a8e7e44cccb7
  grant_number: '101187231'
  name: 'Cavity-Integrated Electro-Optics: Measuring, Converting and Manipulating
    Microwaves with Light'
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
  grant_number: F07105
  name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
    of Superconducting Quantum Circuits
- _id: bdb7cfc1-d553-11ed-ba76-d2eaab167738
  grant_number: '101080139'
  name: Open Superconducting Quantum Computers (OpenSuperQPlus)
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '19073'
    relation: part_of_dissertation
    status: public
  - id: '21870'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
title: Interfacing superconducting qubits with optical photons
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '21870'
abstract:
- lang: eng
  text: Superconducting qubits are a leading candidate for utility-scale quantum computing
    due to their fast gate speeds and steadily decreasing error rates. The requirement
    for millikelvin operating temperatures, however, creates a significant scaling
    bottleneck. Modular architectures using optical fiber links could bridge separate
    cryogenic nodes, but superconducting circuits do not have coherent optical transitions
    and microwave-to-optical conversion has not been shown for any non-classical photon
    state. In this work, we demonstrate the on-demand generation and tomographic reconstruction
    of itinerant single microwave photons at 8.9 GHz from a superconducting qubit.
    We upconvert this non-Gaussian state with a transducer added noise below 0.012
    quanta and count the converted telecom photons at 193.4 THz with a signal-to-noise
    ratio of up to 5.1$\pm$1.1. We characterize the trade-offs between throughput
    and noise, and establish a viable path toward heralded entanglement distribution
    and gate teleportation. Looking ahead, these results empower existing superconducting
    devices to take a key role in distributed quantum technologies and heterogeneous
    quantum systems.
acknowledgement: "We thank Fritz Diorico and Onur Hosten who suggested the filter
  cavity design, and gave important insights about the assembly and the testing of
  the FabryPerot filter cavities. Ekatrina Fedotova and Diego A.\r\nLancheros Naranjo
  worked on the filter cavity setup in\r\nthe early stages of this work. Gustavo Wiederhecker
  and\r\nYiewen Chu provided insights as to the origins of the\r\nobserved optical
  noise and Nicola Carlon Zambon suggested using telecom filters to mitigate it further.
  This\r\nwork was supported by the European Research Council under grant agreement
  no. 101089099 (ERC CoG\r\ncQEO), and 101248662 (ERC POC CoupledEOT), the\r\nEuropean
  Unions Horizon 2020 research and innovation\r\nprogram under grant agreement no.
  899354 (FETopen\r\nSuperQuLAN), the European Innovation Council no.\r\n101187231
  (PathfinderOpen CIELO), and the Austrian\r\nScience Fund (FWF) no. F7105 (SFB BeyondC).
  J.F.\r\nand L.K. acknowledge support from the Horizon Europe\r\nProgram HORIZON-CL4-2022-QUANTUM-01-SGA
  via\r\nProject No. 101113946 OpenSuperQPlus100. A.M. acknowledges support from the
  NOMIS-ISTA fellowship."
article_processing_charge: No
arxiv: 1
author:
- first_name: Thomas
  full_name: Werner, Thomas
  id: 1fcd8497-dba3-11ea-a45e-c6fbd715f7c7
  last_name: Werner
  orcid: 0009-0001-2346-5236
- first_name: Erfan
  full_name: Riyazi, Erfan
  id: 53322f94-5355-11ee-ae5a-ff6f81c87d51
  last_name: Riyazi
- first_name: Samarth
  full_name: Hawaldar, Samarth
  id: 221708e1-1ff6-11ee-9fa6-85146607433e
  last_name: Hawaldar
  orcid: 0000-0002-1965-4309
- first_name: Rishabh
  full_name: Sahu, Rishabh
  id: 47D26E34-F248-11E8-B48F-1D18A9856A87
  last_name: Sahu
  orcid: 0000-0001-6264-2162
- first_name: Georg M
  full_name: Arnold, Georg M
  id: 3770C838-F248-11E8-B48F-1D18A9856A87
  last_name: Arnold
  orcid: 0000-0003-1397-7876
- first_name: Paul Falthansl-Scheinecker
  full_name: Paul Falthansl-Scheinecker, Paul Falthansl-Scheinecker
  last_name: Paul Falthansl-Scheinecker
- first_name: Jennifer A. Sánchez
  full_name: Naranjo, Jennifer A. Sánchez
  last_name: Naranjo
- first_name: Dante
  full_name: Loi, Dante
  last_name: Loi
- first_name: Lucky N.
  full_name: Kapoor, Lucky N.
  last_name: Kapoor
- first_name: Martin
  full_name: Zemlicka, Martin
  id: 2DCF8DE6-F248-11E8-B48F-1D18A9856A87
  last_name: Zemlicka
  orcid: 0009-0005-0878-3032
- first_name: Liu
  full_name: Qiu, Liu
  id: 45e99c0d-1eb1-11eb-9b96-ed8ab2983cac
  last_name: Qiu
  orcid: 0000-0003-4345-4267
- first_name: Andrei
  full_name: Militaru, Andrei
  id: d67706f8-8eb1-11ee-ad1b-9c30dfa19e0b
  last_name: Militaru
- first_name: Johannes M
  full_name: Fink, Johannes M
  id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
  last_name: Fink
  orcid: 0000-0001-8112-028X
citation:
  ama: Werner T, Riyazi E, Hawaldar S, et al. Electro-optic conversion of itinerant
    Fock states. <i>arXiv</i>. doi:<a href="https://doi.org/10.48550/arXiv.2602.00928">10.48550/arXiv.2602.00928</a>
  apa: Werner, T., Riyazi, E., Hawaldar, S., Sahu, R., Arnold, G. M., Paul Falthansl-Scheinecker,
    P. F.-S., … Fink, J. M. (n.d.). Electro-optic conversion of itinerant Fock states.
    <i>arXiv</i>. <a href="https://doi.org/10.48550/arXiv.2602.00928">https://doi.org/10.48550/arXiv.2602.00928</a>
  chicago: Werner, Thomas, Erfan Riyazi, Samarth Hawaldar, Rishabh Sahu, Georg M Arnold,
    Paul Falthansl-Scheinecker Paul Falthansl-Scheinecker, Jennifer A. Sánchez Naranjo,
    et al. “Electro-Optic Conversion of Itinerant Fock States.” <i>ArXiv</i>, n.d.
    <a href="https://doi.org/10.48550/arXiv.2602.00928">https://doi.org/10.48550/arXiv.2602.00928</a>.
  ieee: T. Werner <i>et al.</i>, “Electro-optic conversion of itinerant Fock states,”
    <i>arXiv</i>. .
  ista: Werner T, Riyazi E, Hawaldar S, Sahu R, Arnold GM, Paul Falthansl-Scheinecker
    PF-S, Naranjo JAS, Loi D, Kapoor LN, Zemlicka M, Qiu L, Militaru A, Fink JM. Electro-optic
    conversion of itinerant Fock states. arXiv, <a href="https://doi.org/10.48550/arXiv.2602.00928">10.48550/arXiv.2602.00928</a>.
  mla: Werner, Thomas, et al. “Electro-Optic Conversion of Itinerant Fock States.”
    <i>ArXiv</i>, doi:<a href="https://doi.org/10.48550/arXiv.2602.00928">10.48550/arXiv.2602.00928</a>.
  short: T. Werner, E. Riyazi, S. Hawaldar, R. Sahu, G.M. Arnold, P.F.-S. Paul Falthansl-Scheinecker,
    J.A.S. Naranjo, D. Loi, L.N. Kapoor, M. Zemlicka, L. Qiu, A. Militaru, J.M. Fink,
    ArXiv (n.d.).
corr_author: '1'
date_created: 2026-05-12T13:58:18Z
date_published: 2026-01-31T00:00:00Z
date_updated: 2026-05-20T13:35:42Z
day: '31'
department:
- _id: JoFi
- _id: GradSch
doi: 10.48550/arXiv.2602.00928
ec_funded: 1
external_id:
  arxiv:
  - '2602.00928'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.48550/arXiv.2602.00928
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: bdadfa0d-d553-11ed-ba76-fb85edbd456a
  grant_number: '101089099'
  name: 'Cavity Quantum Electro Optics: Microwave photonics with nonclassical states'
- _id: 5b807754-ab3d-11f0-914f-ff8c34502cc9
  grant_number: '101248662'
  name: Integrated optical coupling for low loss electro-optic interconnects
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
  call_identifier: H2020
  grant_number: '899354'
  name: Quantum Local Area Networks with Superconducting Qubits
- _id: 91aaf765-16d5-11f0-9cad-a8e7e44cccb7
  grant_number: '101187231'
  name: 'Cavity-Integrated Electro-Optics: Measuring, Converting and Manipulating
    Microwaves with Light'
- _id: 26927A52-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: F07105
  name: Integrating superconducting quantum circuits
- _id: 9B861AAC-BA93-11EA-9121-9846C619BF3A
  name: NOMIS Fellowship Program
publication: arXiv
publication_status: draft
related_material:
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scopus_import: '1'
status: public
title: Electro-optic conversion of itinerant Fock states
tmp:
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  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: preprint
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21881'
abstract:
- lang: eng
  text: "I review recent contributions on nonlinear Dirichlet forms. Then, I specialise
    to the case of 2-\r\nhomogeneous and local forms. Inspired by the theory of Finsler
    manifolds and metric measure spaces, I establish new properties of such nonlinear
    Dirichlet forms, which are reminiscent of differential calculus formulae."
acknowledgement: I am thankful to G. Savaré, for introducing me to the study of nonlinear
  Dirichlet forms and metric measure spaces, and to D. Manini for stimulating discussions.
  Open access funding provided by Institute of Science and Technology (IST Austria).
  The author has been funded by the European Union’s Horizon 2020 research and innovation
  program under the Marie Skłodowska-Curie grant agreement No 754362. Partial support
  has been obtained from the EFI ANR-17-CE40-0030 Project of the French National Research
  Agency.
article_number: '33'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Giovanni
  full_name: Brigati, Giovanni
  id: 63ff57e8-1fbb-11ee-88f2-f558ffc59cf1
  last_name: Brigati
citation:
  ama: Brigati G. Nonlinear Dirichlet forms, energy spaces, and calculus rules. <i>La
    Matematica</i>. 2026;5(2). doi:<a href="https://doi.org/10.1007/s44007-026-00217-w">10.1007/s44007-026-00217-w</a>
  apa: Brigati, G. (2026). Nonlinear Dirichlet forms, energy spaces, and calculus
    rules. <i>La Matematica</i>. Springer Nature. <a href="https://doi.org/10.1007/s44007-026-00217-w">https://doi.org/10.1007/s44007-026-00217-w</a>
  chicago: Brigati, Giovanni. “Nonlinear Dirichlet Forms, Energy Spaces, and Calculus
    Rules.” <i>La Matematica</i>. Springer Nature, 2026. <a href="https://doi.org/10.1007/s44007-026-00217-w">https://doi.org/10.1007/s44007-026-00217-w</a>.
  ieee: G. Brigati, “Nonlinear Dirichlet forms, energy spaces, and calculus rules,”
    <i>La Matematica</i>, vol. 5, no. 2. Springer Nature, 2026.
  ista: Brigati G. 2026. Nonlinear Dirichlet forms, energy spaces, and calculus rules.
    La Matematica. 5(2), 33.
  mla: Brigati, Giovanni. “Nonlinear Dirichlet Forms, Energy Spaces, and Calculus
    Rules.” <i>La Matematica</i>, vol. 5, no. 2, 33, Springer Nature, 2026, doi:<a
    href="https://doi.org/10.1007/s44007-026-00217-w">10.1007/s44007-026-00217-w</a>.
  short: G. Brigati, La Matematica 5 (2026).
corr_author: '1'
date_created: 2026-05-17T22:02:10Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-18T08:27:08Z
day: '29'
ddc:
- '510'
department:
- _id: JaMa
doi: 10.1007/s44007-026-00217-w
external_id:
  arxiv:
  - '2309.00377'
file:
- access_level: open_access
  checksum: f75bffe3c793a2cbb26b8494024d0681
  content_type: application/pdf
  creator: dernst
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  date_updated: 2026-05-18T08:26:15Z
  file_id: '21892'
  file_name: 2026_LaMathematica_Brigati.pdf
  file_size: 394082
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has_accepted_license: '1'
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language:
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month: '04'
oa: 1
oa_version: Published Version
publication: La Matematica
publication_identifier:
  eissn:
  - 2730-9657
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Nonlinear Dirichlet forms, energy spaces, and calculus rules
tmp:
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 5
year: '2026'
...
---
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_id: '21882'
abstract:
- lang: eng
  text: The nature of little red dots (LRDs) has largely been investigated through
    their continuum emission, with lines assumed to arise from a broad-line region.
    In this paper, we instead use recombination lines to infer the intrinsic properties
    of the central engine. Our analysis first reveals a tension between the ionizing
    properties implied from Hα and He ii λ4686. The high Hα EWs require copious H-ionizing
    photons, more than the bluest active galactic nucleus (AGN) ionizing spectra can
    provide. In contrast, He ii emission is marginally detected, and its low EW is,
    at most, consistent with the softest AGN spectra. The low He ii/Hβ (∼10−2, <20×  local
    AGN median) further points to an unusually soft ionizing spectrum. We extend our
    analysis to dense gas envelopes (quasi-star/black-hole star) and find that hydrogen
    recombination lines become optically thick and lose diagnostic power, but He ii
    remains optically thin and a robust tracer. Photoionization modeling with Cloudy
    rules out standard AGN accretion disk spectra. Alternative explanations include
    exotic AGN with red rest-optical emission, high average optical depth (>10) from
    gas/dust, and soft ionizing spectra with abundant H-ionizing photons, consistent
    with, e.g., a cold accretion disk or a composite of AGN and stars. The latter
    is an intriguing scenario since high hydrogen densities are highly conducive for
    star formation, and nuclear star clusters are found in the vicinity of local massive
    black holes. While previous studies have mostly focused on features dominated
    by the absorbing hydrogen cloud, the He ii-based diagnostic proposed here represents
    a crucial step toward understanding the central engine of LRDs.
acknowledgement: "B.W. thanks Michael Eracleous for valuable discussions. B.W. and
  J.L. acknowledge support from JWST-GO-04233.009. B.W. also acknowledges support
  provided by NASA through Hubble Fellowship grant HST-HF2-51592.001 awarded by the
  Space Telescope Science Institute, which is operated by the Association of Universities
  for Research in Astronomy, Inc., for NASA, under the contract NAS 5-26555. K.I.
  acknowledges support from the National Natural Science Foundation of China (12573015,
  W2532003), the Beijing Natural Science Foundation (IS25003), and the China Manned
  Space Program (CMS-CSST-2025-A09). R.E.H. acknowledges support by the German Aerospace
  Center (DLR) and the Federal Ministry for Economic Affairs and Energy (BMWi) through
  program 50OR2403 “RUBIES.”\r\n\r\nThis work is based on observations made with the
  NASA/ESA/CSA James Webb Space Telescope. The data were obtained from the Mikulski
  Archive for Space Telescopes at the Space Telescope Science Institute, which is
  operated by the Association of Universities for Research in Astronomy, Inc., under
  NASA contract NAS 5-03127 for JWST. These observations are associated with program
  # 1433, 2561, 4106, 4233, 5224, 6585. The specific observations analyzed can be
  accessed via DOI: 10.17909/9hpc-nc45. Computations for this research were performed
  on the Pennsylvania State University’s Institute for Computational and Data Sciences’
  Roar supercomputer; and on computational resources managed and supported by Princeton
  Research Computing, a consortium of groups including the Princeton Institute for
  Computational Science and Engineering (PICSciE) and Research Computing at Princeton
  University. Some of the stellar spectra are retrieved from the POLLUX database (pollux.oreme.org)
  operated at LUPM (Université de Montpellier—CNRS, France) with the support of the
  PNPS and INSU. This publication made use of the NASA Astrophysical Data System for
  bibliographic information."
article_number: '10'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Bingjie
  full_name: Wang, Bingjie
  last_name: Wang
- first_name: Joel
  full_name: Leja, Joel
  last_name: Leja
- first_name: Harley
  full_name: Katz, Harley
  last_name: Katz
- first_name: Kohei
  full_name: Inayoshi, Kohei
  last_name: Inayoshi
- first_name: Nikko J.
  full_name: Cleri, Nikko J.
  last_name: Cleri
- first_name: Anna
  full_name: De Graaff, Anna
  last_name: De Graaff
- first_name: Raphael E.
  full_name: Hviding, Raphael E.
  last_name: Hviding
- first_name: Pieter
  full_name: Van Dokkum, Pieter
  last_name: Van Dokkum
- first_name: Jenny E.
  full_name: Greene, Jenny E.
  last_name: Greene
- first_name: Ivo
  full_name: Labbé, Ivo
  last_name: Labbé
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Ian
  full_name: Mcconachie, Ian
  last_name: Mcconachie
- first_name: Rohan P.
  full_name: Naidu, Rohan P.
  last_name: Naidu
- first_name: Erica J.
  full_name: Nelson, Erica J.
  last_name: Nelson
citation:
  ama: 'Wang B, Leja J, Katz H, et al. The missing hard photons of Little Red Dots:
    Their incident ionizing spectra resemble massive stars. <i>The Astrophysical Journal</i>.
    2026;1003(1). doi:<a href="https://doi.org/10.3847/1538-4357/ae5bab">10.3847/1538-4357/ae5bab</a>'
  apa: 'Wang, B., Leja, J., Katz, H., Inayoshi, K., Cleri, N. J., De Graaff, A., …
    Nelson, E. J. (2026). The missing hard photons of Little Red Dots: Their incident
    ionizing spectra resemble massive stars. <i>The Astrophysical Journal</i>. IOP
    Publishing. <a href="https://doi.org/10.3847/1538-4357/ae5bab">https://doi.org/10.3847/1538-4357/ae5bab</a>'
  chicago: 'Wang, Bingjie, Joel Leja, Harley Katz, Kohei Inayoshi, Nikko J. Cleri,
    Anna De Graaff, Raphael E. Hviding, et al. “The Missing Hard Photons of Little
    Red Dots: Their Incident Ionizing Spectra Resemble Massive Stars.” <i>The Astrophysical
    Journal</i>. IOP Publishing, 2026. <a href="https://doi.org/10.3847/1538-4357/ae5bab">https://doi.org/10.3847/1538-4357/ae5bab</a>.'
  ieee: 'B. Wang <i>et al.</i>, “The missing hard photons of Little Red Dots: Their
    incident ionizing spectra resemble massive stars,” <i>The Astrophysical Journal</i>,
    vol. 1003, no. 1. IOP Publishing, 2026.'
  ista: 'Wang B, Leja J, Katz H, Inayoshi K, Cleri NJ, De Graaff A, Hviding RE, Van
    Dokkum P, Greene JE, Labbé I, Matthee JJ, Mcconachie I, Naidu RP, Nelson EJ. 2026.
    The missing hard photons of Little Red Dots: Their incident ionizing spectra resemble
    massive stars. The Astrophysical Journal. 1003(1), 10.'
  mla: 'Wang, Bingjie, et al. “The Missing Hard Photons of Little Red Dots: Their
    Incident Ionizing Spectra Resemble Massive Stars.” <i>The Astrophysical Journal</i>,
    vol. 1003, no. 1, 10, IOP Publishing, 2026, doi:<a href="https://doi.org/10.3847/1538-4357/ae5bab">10.3847/1538-4357/ae5bab</a>.'
  short: B. Wang, J. Leja, H. Katz, K. Inayoshi, N.J. Cleri, A. De Graaff, R.E. Hviding,
    P. Van Dokkum, J.E. Greene, I. Labbé, J.J. Matthee, I. Mcconachie, R.P. Naidu,
    E.J. Nelson, The Astrophysical Journal 1003 (2026).
date_created: 2026-05-17T22:02:10Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-18T08:18:39Z
day: '01'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.3847/1538-4357/ae5bab
external_id:
  arxiv:
  - '2508.18358'
file:
- access_level: open_access
  checksum: ee9ebc8ae2304fec04f24b82ebaac8bc
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  creator: dernst
  date_created: 2026-05-18T08:17:26Z
  date_updated: 2026-05-18T08:17:26Z
  file_id: '21891'
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  file_size: 2584417
  relation: main_file
  success: 1
file_date_updated: 2026-05-18T08:17:26Z
has_accepted_license: '1'
intvolume: '      1003'
issue: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: The Astrophysical Journal
publication_identifier:
  eissn:
  - 1538-4357
  issn:
  - 0004-637X
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The missing hard photons of Little Red Dots: Their incident ionizing spectra
  resemble massive stars'
tmp:
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 1003
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21884'
abstract:
- lang: eng
  text: "We show that a randomly perturbed digraph, where we start with a dense digraph
    Dα and add a small number of random edges to it, will typically contain a fixed
    orientation of a bounded-degree spanning tree. This answers a question posed by
    Araujo, Balogh, Krueger, Piga and Treglown and generalizes the corresponding result
    for randomly perturbed graphs by Krivelevich, Kwan and Sudakov. More specifically,
    we prove that there exists a constant c=c(α,Δ) such that if \r\nT is an oriented
    tree with maximum degree Δ and Dα is an n-vertex digraph with minimum semidegree
    αn, then the graph obtained by adding cn uniformly random edges to Dα will contain
    T with high probability."
acknowledgement: "We thank the anonymous referees for many helpful comments on an
  earlier version of this\r\narticle. Kalina Petrova was supported by grant no. CRSII5
  173721 of the Swiss National\r\nScience Foundation, and by the European Union’s
  Horizon 2020 research and innovation\r\nprogramme under the Marie Sk lodowska-Curie
  grant agreement No. 101034413"
article_number: P2.24
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Patryk
  full_name: Morawski, Patryk
  last_name: Morawski
- first_name: Kalina H
  full_name: Petrova, Kalina H
  id: 554ff4e4-f325-11ee-b0c4-a10dbd523381
  last_name: Petrova
citation:
  ama: Morawski P, Petrova KH. Randomly perturbed digraphs also have bounded-degree
    spanning trees. <i>Electronic Journal of Combinatorics</i>. 2026;33(2). doi:<a
    href="https://doi.org/10.37236/13316">10.37236/13316</a>
  apa: Morawski, P., &#38; Petrova, K. H. (2026). Randomly perturbed digraphs also
    have bounded-degree spanning trees. <i>Electronic Journal of Combinatorics</i>.
    Electronic Journal of Combinatorics. <a href="https://doi.org/10.37236/13316">https://doi.org/10.37236/13316</a>
  chicago: Morawski, Patryk, and Kalina H Petrova. “Randomly Perturbed Digraphs Also
    Have Bounded-Degree Spanning Trees.” <i>Electronic Journal of Combinatorics</i>.
    Electronic Journal of Combinatorics, 2026. <a href="https://doi.org/10.37236/13316">https://doi.org/10.37236/13316</a>.
  ieee: P. Morawski and K. H. Petrova, “Randomly perturbed digraphs also have bounded-degree
    spanning trees,” <i>Electronic Journal of Combinatorics</i>, vol. 33, no. 2. Electronic
    Journal of Combinatorics, 2026.
  ista: Morawski P, Petrova KH. 2026. Randomly perturbed digraphs also have bounded-degree
    spanning trees. Electronic Journal of Combinatorics. 33(2), P2.24.
  mla: Morawski, Patryk, and Kalina H. Petrova. “Randomly Perturbed Digraphs Also
    Have Bounded-Degree Spanning Trees.” <i>Electronic Journal of Combinatorics</i>,
    vol. 33, no. 2, P2.24, Electronic Journal of Combinatorics, 2026, doi:<a href="https://doi.org/10.37236/13316">10.37236/13316</a>.
  short: P. Morawski, K.H. Petrova, Electronic Journal of Combinatorics 33 (2026).
corr_author: '1'
date_created: 2026-05-17T22:02:11Z
date_published: 2026-05-08T00:00:00Z
date_updated: 2026-05-18T08:50:18Z
day: '08'
ddc:
- '510'
department:
- _id: MaKw
doi: 10.37236/13316
ec_funded: 1
external_id:
  arxiv:
  - '2306.14648'
file:
- access_level: open_access
  checksum: 9e8402cb2e8870ba7ded9ae7b308201a
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-18T08:46:26Z
  date_updated: 2026-05-18T08:46:26Z
  file_id: '21893'
  file_name: 2026_ElectrJournCombinatorics_Morawski.pdf
  file_size: 399969
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  success: 1
file_date_updated: 2026-05-18T08:46:26Z
has_accepted_license: '1'
intvolume: '        33'
issue: '2'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Electronic Journal of Combinatorics
publication_identifier:
  eissn:
  - 1077-8926
publication_status: published
publisher: Electronic Journal of Combinatorics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Randomly perturbed digraphs also have bounded-degree spanning trees
tmp:
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  short: CC BY-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 33
year: '2026'
...
---
APC_amount: 1352,08 EUR
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21894'
abstract:
- lang: eng
  text: "The Dean–Kawasaki equation—one of the most fundamental SPDEs of\r\nfluctuating
    hydrodynamics—has been proposed as a model for density fluctuations in weakly
    interacting particle systems. In its original form, it is highly\r\nsingular and
    fails to be renormalizable, even by approaches such as regularity structures and
    paracontrolled distributions, hindering mathematical approaches to its rigorous
    justification. It has been understood recently that it is\r\nnatural to introduce
    a suitable regularization, for example, by applying a formal spatial discretization
    or by truncating high-frequency noise: This yields\r\nwell-posed equations that
    should still precisely approximate the law of the\r\nparticle density fluctuations.\r\nIn
    the present work, we prove that a regularization in the form of a formal\r\ndiscretization
    of the Dean–Kawasaki equation indeed accurately describes\r\ndensity fluctuations
    in systems of weakly interacting diffusing particles: We\r\nshow that, in suitable
    weak metrics, the law of fluctuations as predicted by\r\nthe discretized Dean–Kawasaki
    SPDE approximates the law of fluctuations\r\nof the original particle system,
    up to an error that is of arbitrarily high order in\r\nthe inverse particle number
    and a discretization error. In particular, the Dean–\r\nKawasaki equation provides
    a means for efficient and accurate simulations of\r\ndensity fluctuations in weakly
    interacting particle systems."
acknowledgement: All authors gratefully acknowledge funding from the Austrian Science
  Fund (FWF) through the project F65. CR gratefully acknowledges support from the
  Austrian Science Fund (FWF), grants P30000, P33010, W1245. FC gratefully acknowledges
  funding from the European Union’s Horizon 2020 research and innovation programme
  under the Marie Skłodowska-Curie grant agreement No. 754411.
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Federico
  full_name: Cornalba, Federico
  last_name: Cornalba
- first_name: Julian L
  full_name: Fischer, Julian L
  id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
  last_name: Fischer
  orcid: 0000-0002-0479-558X
- first_name: Jonas
  full_name: Ingmanns, Jonas
  id: 71523d30-15b2-11ec-abd3-f80aa909d6b0
  last_name: Ingmanns
  orcid: 0009-0008-1310-7946
- first_name: Claudia
  full_name: Raithel, Claudia
  last_name: Raithel
citation:
  ama: Cornalba F, Fischer JL, Ingmanns J, Raithel C. Density fluctuations in weakly
    interacting particle systems via the Dean–Kawasaki equation. <i>The Annals of
    Probability</i>. 2026;54(1):155-215. doi:<a href="https://doi.org/10.1214/25-aop1763">10.1214/25-aop1763</a>
  apa: Cornalba, F., Fischer, J. L., Ingmanns, J., &#38; Raithel, C. (2026). Density
    fluctuations in weakly interacting particle systems via the Dean–Kawasaki equation.
    <i>The Annals of Probability</i>. Institute of Mathematical Statistics. <a href="https://doi.org/10.1214/25-aop1763">https://doi.org/10.1214/25-aop1763</a>
  chicago: Cornalba, Federico, Julian L Fischer, Jonas Ingmanns, and Claudia Raithel.
    “Density Fluctuations in Weakly Interacting Particle Systems via the Dean–Kawasaki
    Equation.” <i>The Annals of Probability</i>. Institute of Mathematical Statistics,
    2026. <a href="https://doi.org/10.1214/25-aop1763">https://doi.org/10.1214/25-aop1763</a>.
  ieee: F. Cornalba, J. L. Fischer, J. Ingmanns, and C. Raithel, “Density fluctuations
    in weakly interacting particle systems via the Dean–Kawasaki equation,” <i>The
    Annals of Probability</i>, vol. 54, no. 1. Institute of Mathematical Statistics,
    pp. 155–215, 2026.
  ista: Cornalba F, Fischer JL, Ingmanns J, Raithel C. 2026. Density fluctuations
    in weakly interacting particle systems via the Dean–Kawasaki equation. The Annals
    of Probability. 54(1), 155–215.
  mla: Cornalba, Federico, et al. “Density Fluctuations in Weakly Interacting Particle
    Systems via the Dean–Kawasaki Equation.” <i>The Annals of Probability</i>, vol.
    54, no. 1, Institute of Mathematical Statistics, 2026, pp. 155–215, doi:<a href="https://doi.org/10.1214/25-aop1763">10.1214/25-aop1763</a>.
  short: F. Cornalba, J.L. Fischer, J. Ingmanns, C. Raithel, The Annals of Probability
    54 (2026) 155–215.
corr_author: '1'
date_created: 2026-05-20T08:25:25Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-05-21T07:21:25Z
day: '01'
ddc:
- '510'
department:
- _id: JuFi
doi: 10.1214/25-aop1763
ec_funded: 1
external_id:
  arxiv:
  - '2303.00429'
file:
- access_level: open_access
  checksum: 3e60c0e25a1c96342029a7d2b031505f
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-21T07:11:27Z
  date_updated: 2026-05-21T07:11:27Z
  file_id: '21906'
  file_name: 2026_AnnalsProbability_Cornalba.pdf
  file_size: 865745
  relation: main_file
  success: 1
file_date_updated: 2026-05-21T07:11:27Z
has_accepted_license: '1'
intvolume: '        54'
issue: '1'
keyword:
- Weakly interacting particle systems
- fluctuating hydrodynamics
- Dean-Kawasaki equation
- stochastic PDEs
- numerical approximation
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 155-215
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
  grant_number: F6504
  name: Taming Complexity in Partial Differential Systems
publication: The Annals of Probability
publication_identifier:
  eissn:
  - 2168-894X
  issn:
  - 0091-1798
publication_status: published
publisher: Institute of Mathematical Statistics
quality_controlled: '1'
scopus_import: '1'
status: public
title: Density fluctuations in weakly interacting particle systems via the Dean–Kawasaki
  equation
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21895'
abstract:
- lang: eng
  text: The mammalian brain organises knowledge about entities in the world and relationships
    between them using cognitive maps. When forming a cognitive map, there is a necessary
    trade-off between extending the map to make novel inferences, and storing a veridical
    copy of past experience. However, the neural mechanisms that control this trade-off
    remain unknown. Using a cross-scale approach that combines a pharmacological intervention
    in humans with neural network modelling, we show that the neuromodulator noradrenaline
    elicits a significant ‘spread of association’ across hippocampal cognitive maps.
    This neural spread of association can be explained by changes in synaptic plasticity
    that predict overgeneralisation in behaviour. Thus, elevated noradrenaline during
    learning increases the ‘smoothing kernel’ for plasticity across the cognitive
    map, allowing disparate memories to become linked and distorted.
acknowledgement: 'We would like to thank Chamith Halahakoon, Phil Cowen, Angharad
  De Cates, Beata Godlewska, Riccardo De Giorgi, Katherine Smith and Edoardo Ostinelli
  for enabling this study by providing medical cover. We would like to thank Douglas
  F. Tomé and Everton J. Agnes for their guidance and advice with earlier versions
  of the neural network model. We would like to thank Rob Froemke for helpful discussion
  when preparing the experiments. We thank Leonie Glitz and Valentina Mancini for
  comments on an earlier version of the manuscript. R.S.K. was supported by an EPSRC/MRC-funded
  studentship (EP/L016052/1). P.P. was supported by the Cambridge Trust, Trinity Henry
  Barlow Scholarship and Trinity Hall Brockhouse Scholarship. L.C. is supported by
  the Foundation for Science and Technology (FCT) (Portuguese State Budget: UID/PSI/01662/2020;
  Research fellowship: 2021.00415.CEECIND). W.T.C. is funded by the Wellcome Trust
  [225924/Z/22/Z]. H.C.B. is supported by a UKRI Future Leaders Fellowship (MR/W008939/1)
  and the Wellcome Institutional Strategic Support Fund. H.C.B. and J.X.O. are supported
  by the Medical Research Council (MR/W01971X/1). The study was supported by the NIHR
  Oxford Health Biomedical Research Centre (NIHR203316). The views expressed are those
  of the author(s) and not necessarily those of the NIHR or the Department of Health
  and Social Care. The Wellcome Centre for Integrative Neuroimaging is supported by
  core funding from the Wellcome Trust (203139/Z/16/Z and 203139/A/16/Z). This research
  was funded in part by the Wellcome Trust. For the purpose of open access, the author(s)
  have applied a CC BY public copyright license to any Author Accepted Manuscript
  version arising from this submission.'
article_number: '3961'
article_processing_charge: Yes
article_type: original
author:
- first_name: Renée S.
  full_name: Koolschijn, Renée S.
  last_name: Koolschijn
- first_name: Prakriti
  full_name: Parthasarathy, Prakriti
  last_name: Parthasarathy
- first_name: Michael
  full_name: Browning, Michael
  last_name: Browning
- first_name: Xenia
  full_name: Przygodda, Xenia
  last_name: Przygodda
- first_name: Liliana P.
  full_name: Capitão, Liliana P.
  last_name: Capitão
- first_name: William T.
  full_name: Clarke, William T.
  last_name: Clarke
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Jill X.
  full_name: O’Reilly, Jill X.
  last_name: O’Reilly
- first_name: Helen C.
  full_name: Barron, Helen C.
  last_name: Barron
citation:
  ama: Koolschijn RS, Parthasarathy P, Browning M, et al. Noradrenaline causes a spread
    of association in the hippocampal cognitive map. <i>Nature Communications</i>.
    2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-70659-x">10.1038/s41467-026-70659-x</a>
  apa: Koolschijn, R. S., Parthasarathy, P., Browning, M., Przygodda, X., Capitão,
    L. P., Clarke, W. T., … Barron, H. C. (2026). Noradrenaline causes a spread of
    association in the hippocampal cognitive map. <i>Nature Communications</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s41467-026-70659-x">https://doi.org/10.1038/s41467-026-70659-x</a>
  chicago: Koolschijn, Renée S., Prakriti Parthasarathy, Michael Browning, Xenia Przygodda,
    Liliana P. Capitão, William T. Clarke, Tim P Vogels, Jill X. O’Reilly, and Helen
    C. Barron. “Noradrenaline Causes a Spread of Association in the Hippocampal Cognitive
    Map.” <i>Nature Communications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-70659-x">https://doi.org/10.1038/s41467-026-70659-x</a>.
  ieee: R. S. Koolschijn <i>et al.</i>, “Noradrenaline causes a spread of association
    in the hippocampal cognitive map,” <i>Nature Communications</i>, vol. 17. Springer
    Nature, 2026.
  ista: Koolschijn RS, Parthasarathy P, Browning M, Przygodda X, Capitão LP, Clarke
    WT, Vogels TP, O’Reilly JX, Barron HC. 2026. Noradrenaline causes a spread of
    association in the hippocampal cognitive map. Nature Communications. 17, 3961.
  mla: Koolschijn, Renée S., et al. “Noradrenaline Causes a Spread of Association
    in the Hippocampal Cognitive Map.” <i>Nature Communications</i>, vol. 17, 3961,
    Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-70659-x">10.1038/s41467-026-70659-x</a>.
  short: R.S. Koolschijn, P. Parthasarathy, M. Browning, X. Przygodda, L.P. Capitão,
    W.T. Clarke, T.P. Vogels, J.X. O’Reilly, H.C. Barron, Nature Communications 17
    (2026).
date_created: 2026-05-20T14:30:37Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-21T07:05:01Z
day: '01'
ddc:
- '570'
department:
- _id: TiVo
doi: 10.1038/s41467-026-70659-x
external_id:
  pmid:
  - '41832186'
file:
- access_level: open_access
  checksum: 1b529e06b1c5d6e085d60743317fd4f9
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-21T07:01:35Z
  date_updated: 2026-05-21T07:01:35Z
  file_id: '21905'
  file_name: 2026_NatureComm_Koolschijn.pdf
  file_size: 2059139
  relation: main_file
  success: 1
file_date_updated: 2026-05-21T07:01:35Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Noradrenaline causes a spread of association in the hippocampal cognitive map
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21897'
abstract:
- lang: eng
  text: Ultracompact binary systems, consisting of two compact objects in an orbit
    $\lesssim 0.5 {\rm R}_\odot$, should exhibit measurable rates of orbital period
    change ($\dot{P} \ne 0$) due to the emission of gravitational waves (GWs). Measurements
    of $\dot{P}$ have so far been limited to the shortest-period ultracompact binaries
    ($\lesssim 20$  min). Among the AM CVn-type subclass, several works have proposed
    the presence of extra angular momentum loss beyond GW emission, with magnetic
    braking being a widely discussed mechanism. If present, this magnetic braking
    would dominate the angular momentum loss of AM CVn-type binaries with orbital
    periods $\gtrsim 30$ min. In this work, we present a long-term eclipse timing
    study of two AM CVn-type binaries, YZ LMi and Gaia14aae, with respective orbital
    periods of 28.3 min and 49.7 min and continuous observations since 2006 and 2015.
    Both systems show $\dot{P}$ consistent with zero within $2\sigma$. Their $3\sigma$
    upper limits are $1.1 \times 10^{-13}\, {\rm s \, s}^{-1}$ and $9.7 \times 10^{-14}\,
    {\rm s \, s}^{-1}$, respectively. These non-detections are most simply explained
    by a scenario in which secular angular momentum loss is not substantially stronger
    than GW emission at all orbital periods, but is combined with deviations from
    the secular $\dot{P}$ whose time-scales span decades but whose amplitude is $\lesssim
    10^{-13}\, {\rm s \, s}^{-1}$. Our non-detections of $\dot{P}$ represent a limit
    on the strength of any enhanced angular momentum loss beyond pure GW emission.
acknowledgement: "We are grateful to the anonymousreferee fortheirinsightful comments.
  MJG thanks Mitch Begelman and the JILA department at the University of Colorado,
  Boulder, for providing office space at which much of this paper was written. This
  work is supported in part by the United States National Aeronautics and Space Administration
  (NASA) under grants\r\n80NSSC24K0436, 80NSSC22K0479, and 80NSSC24K0380, and the
  United States National Science Foundation (NSF) under grant AST-2508429. VSD and
  HiPERCAM are funded by the Science and Technology Facilities Council (grant ST/Z000033/1).
  IP acknowledges support from the Royal Society through a University Research Fellowship
  (URF\\R1\\231496). This project has received funding from the European Research
  Council under the European Union’s Horizon 2020 research and innovation programme
  (grant agreement numbers 101002408 – MOS100PC). CMC receives funding from United
  Kingdom Research and Innovation grant numbers ST/X005933/1 and ST/W001934/1. This
  article is based in part on observations made in the Observatorios de Canarias del
  Instituto de Astrofísica de Canarias (IAC) with the the William Herschel Telescope
  (WHT) operated on the island of La Palma by the Isaac Newton Group (ING) in the
  Observatorio del Roque de los Muchachos. It is also based in part on observations
  made with the Gran Telescopio Canarias (GTC) under proposal ID GTC18-24A, installed
  at the Spanish Observatorio del Roque de los Muchachos of the Instituto de Astrofísica
  de Canarias, in the island of La Palma. Further data were obtained using the 2.4
  m Thai National Telescope (TNT) operated by the National Astronomy Research Institute
  of Thailand\r\n(NARIT), and the 200-inch Hale Telescope at Palomar Observatory operated
  by the California Institute of Technology. Software packages used in this work include
  the ultracam and hipercam reduction pipelines, lcurve (C. M. Copperwheat et al.
  2010), numpy, astropy, matplotlib, and emcee (D. Foreman-Mackey et al. 2013)."
article_number: stag673
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Matthew J
  full_name: Green, Matthew J
  last_name: Green
- first_name: Thomas R
  full_name: Marsh, Thomas R
  last_name: Marsh
- first_name: Joannes C
  full_name: van Roestel, Joannes C
  id: 4d122fc8-6083-11f0-87a5-97d68b860333
  last_name: van Roestel
- first_name: Tin Long Sunny
  full_name: Wong, Tin Long Sunny
  last_name: Wong
- first_name: Diogo
  full_name: Belloni, Diogo
  last_name: Belloni
- first_name: Mukremin
  full_name: Kilic, Mukremin
  last_name: Kilic
- first_name: Elmé
  full_name: Breedt, Elmé
  last_name: Breedt
- first_name: Alex
  full_name: Brown, Alex
  last_name: Brown
- first_name: Chris M
  full_name: Copperwheat, Chris M
  last_name: Copperwheat
- first_name: Anurak
  full_name: Chakpor, Anurak
  last_name: Chakpor
- first_name: V S
  full_name: Dhillon, V S
  last_name: Dhillon
- first_name: Noel Castro
  full_name: Segura, Noel Castro
  last_name: Segura
- first_name: Martin J
  full_name: Dyer, Martin J
  last_name: Dyer
- first_name: James
  full_name: Garbutt, James
  last_name: Garbutt
- first_name: Dan
  full_name: Jarvis, Dan
  last_name: Jarvis
- first_name: Vasu
  full_name: Kengkriangkrai, Vasu
  last_name: Kengkriangkrai
- first_name: Mark R
  full_name: Kennedy, Mark R
  last_name: Kennedy
- first_name: Paul
  full_name: Kerry, Paul
  last_name: Kerry
- first_name: Thomas
  full_name: Kupfer, Thomas
  last_name: Kupfer
- first_name: S P
  full_name: Littlefair, S P
  last_name: Littlefair
- first_name: James
  full_name: McCormac, James
  last_name: McCormac
- first_name: James
  full_name: Munday, James
  last_name: Munday
- first_name: Steven G
  full_name: Parsons, Steven G
  last_name: Parsons
- first_name: Eleanor
  full_name: Pike, Eleanor
  last_name: Pike
- first_name: Ingrid
  full_name: Pelisoli, Ingrid
  last_name: Pelisoli
- first_name: Pablo
  full_name: Rodríguez-Gil, Pablo
  last_name: Rodríguez-Gil
- first_name: David I
  full_name: Sahman, David I
  last_name: Sahman
- first_name: Amalie
  full_name: Yates, Amalie
  last_name: Yates
citation:
  ama: Green MJ, Marsh TR, van Roestel JC, et al. No period change in two long-period
    AM CVn binaries. <i>Monthly Notices of the Royal Astronomical Society</i>. 2026;548(3).
    doi:<a href="https://doi.org/10.1093/mnras/stag673">10.1093/mnras/stag673</a>
  apa: Green, M. J., Marsh, T. R., van Roestel, J. C., Wong, T. L. S., Belloni, D.,
    Kilic, M., … Yates, A. (2026). No period change in two long-period AM CVn binaries.
    <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University Press.
    <a href="https://doi.org/10.1093/mnras/stag673">https://doi.org/10.1093/mnras/stag673</a>
  chicago: Green, Matthew J, Thomas R Marsh, Joannes C van Roestel, Tin Long Sunny
    Wong, Diogo Belloni, Mukremin Kilic, Elmé Breedt, et al. “No Period Change in
    Two Long-Period AM CVn Binaries.” <i>Monthly Notices of the Royal Astronomical
    Society</i>. Oxford University Press, 2026. <a href="https://doi.org/10.1093/mnras/stag673">https://doi.org/10.1093/mnras/stag673</a>.
  ieee: M. J. Green <i>et al.</i>, “No period change in two long-period AM CVn binaries,”
    <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 548, no. 3. Oxford
    University Press, 2026.
  ista: Green MJ, Marsh TR, van Roestel JC, Wong TLS, Belloni D, Kilic M, Breedt E,
    Brown A, Copperwheat CM, Chakpor A, Dhillon VS, Segura NC, Dyer MJ, Garbutt J,
    Jarvis D, Kengkriangkrai V, Kennedy MR, Kerry P, Kupfer T, Littlefair SP, McCormac
    J, Munday J, Parsons SG, Pike E, Pelisoli I, Rodríguez-Gil P, Sahman DI, Yates
    A. 2026. No period change in two long-period AM CVn binaries. Monthly Notices
    of the Royal Astronomical Society. 548(3), stag673.
  mla: Green, Matthew J., et al. “No Period Change in Two Long-Period AM CVn Binaries.”
    <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 548, no. 3, stag673,
    Oxford University Press, 2026, doi:<a href="https://doi.org/10.1093/mnras/stag673">10.1093/mnras/stag673</a>.
  short: M.J. Green, T.R. Marsh, J.C. van Roestel, T.L.S. Wong, D. Belloni, M. Kilic,
    E. Breedt, A. Brown, C.M. Copperwheat, A. Chakpor, V.S. Dhillon, N.C. Segura,
    M.J. Dyer, J. Garbutt, D. Jarvis, V. Kengkriangkrai, M.R. Kennedy, P. Kerry, T.
    Kupfer, S.P. Littlefair, J. McCormac, J. Munday, S.G. Parsons, E. Pike, I. Pelisoli,
    P. Rodríguez-Gil, D.I. Sahman, A. Yates, Monthly Notices of the Royal Astronomical
    Society 548 (2026).
date_created: 2026-05-20T14:34:03Z
date_published: 2026-04-09T00:00:00Z
date_updated: 2026-05-21T06:41:41Z
day: '09'
ddc:
- '520'
department:
- _id: IlCa
doi: 10.1093/mnras/stag673
external_id:
  arxiv:
  - '2604.06460'
file:
- access_level: open_access
  checksum: 2c4463926c5cb84ce555ef2005b52ddd
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-21T06:37:42Z
  date_updated: 2026-05-21T06:37:42Z
  file_id: '21903'
  file_name: 2026_MNRAS_Green.pdf
  file_size: 3960296
  relation: main_file
  success: 1
file_date_updated: 2026-05-21T06:37:42Z
has_accepted_license: '1'
intvolume: '       548'
issue: '3'
keyword:
- 'binaries: close – stars'
- dwarf novae – novae
- cataclysmic variables – white dwarfs
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  eissn:
  - 1365-2966
  issn:
  - 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: No period change in two long-period AM CVn binaries
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 548
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21898'
abstract:
- lang: eng
  text: We investigate the nature and spectroscopic diversity of early galaxies from
    a sample of 41 sources at $z\geqslant 10$ with James Webb Space Telescope (JWST)/NIRSpec
    prism observations. We compare the properties of strong ultraviolet (UV) line
    emitters, traced by intense C iv emission, with those of more ‘typical’ sources
    with weak or undetected C iv. The more typical (or ‘C iv-weak’) sources reveal
    significant scatter in their C iii] line strengths, UV continuum slopes, and physical
    sizes, spanning C iii] equivalent widths (EWs) of $\sim$1–51 Å, UV slopes of $\beta
    \sim -1.6$ to $-2.6$, and half-light radii of $\sim$50–1000 pc. In contrast, C iv-strong
    sources occupy the tail of these distributions, with C iii] EWs of 16–51 Å, UV
    slopes $\beta \lesssim -2.5$, compact morphologies ($r_{\rm 50} \lesssim 100$ pc),
    and elevated star formation surface densities ($\Sigma _{\rm SFR} \gtrsim 100\,
    M_\odot \, \mathrm{yr}^{-1}\, \mathrm{kpc}^{-2}$). These properties suggest concentrated
    starbursts that temporarily outshine the host galaxy. Comparing average properties
    from composite spectra, we find the diversity of the sample is primarily driven
    by bursty star formation on very short time-scales ($\le$3 Myr), with strong C iv
    emitters observed at the apex of the bursts and sources devoid of emission lines
    during relative inactivity. An apparent association between strong C iv and enhanced
    nitrogen abundance suggests both may be modulated by the same duty cycle, reflecting
    a generic mode of star formation. We show that active galactic nuclei are unlikely
    to contribute significantly to this duty cycle based on UV line diagnostics and
    photoionization models. Our results support a picture whereby brief bursts and
    lulls can explain the spectral diversity and early growth of bright galaxies in
    the first 500 Myr.
acknowledgement: "We thank the anonymous referee for useful and constructive\r\nfeedback
  that improved the manuscript. GRB is grateful to Vasily\r\nBelokurov and Sarah Kane
  for providing the relevant abundances\r\nforthe Aurora data in Fig. 11, as well
  asto Tiger Yu-Yang Hsiao for\r\nhelpful discussions regarding the MACS 0647-JD source.
  We are\r\nalso grateful to Gabe Brammerfor useful discussions and his continuous
  efforts in maintaining and improving the msaexp code,\r\nfrom which the high-z community
  continues to benefit greatly.\r\nLastly, we also thank the numerous teams of the
  observational\r\nprograms used in this study, for developing these valuable data\r\nsets.
  The data used in this study are derived from the following\r\nprograms: 1181 (PI
  Eisenstein; D. J. Eisenstein et al. 2023a), 1210\r\n(PI Luetzgendorf; D. J. Eisenstein
  et al. 2023a), 1211 (PI Isaak;\r\nM. V. Maseda et al. 2024), 1286 (PI Luetzgendorf;
  D. J. Eisenstein\r\net al. 2023a), 1287 (PI Isaak; D. J. Eisenstein et al. 2023a),
  1345\r\n(PI Finkelstein; S. L. Finkelstein et al. 2025), 1433 (PI Coe; T. Y.-\r\nY.
  Hsiao et al. 2024a), 2561 (PI Labbé; R. Bezanson et al. 2022),\r\n2750 (PI Arrabal
  Haro; P. Arrabal Haro et al. 2023b), 3073 (PI\r\nCastellano; M. Castellano et al.
  2024), 3215 (PIs Eisenstein &\r\nMaiolino; D. J. Eisenstein et al. 2023b), 5224
  (PIs Oesch & Naidu;\r\nOesch et al. in preparation), 6368 (PI Dickinson; V. Kokorev
  et al.\r\n2025). The authors acknowledge the aforementioned teams and\r\nPIs where
  development of their observing program(s) was done\r\nwith a zero-exclusive-access
  period.\r\nThis work is based on observations made with the\r\nNASA/ESA/CSA JWST.
  The data were obtained from the\r\nMikulski Archive for Space Telescopes at the
  Space Telescope\r\nScience Institute, which is operated by the Association of\r\nUniversities
  for Research in Astronomy, Inc., under NASA\r\ncontract NAS 5-03127 for JWST. The
  specific observations\r\nanalysed can be accessed via DOI 10.17909/jqj3-ws37. Some\r\nof
  the data products presented herein were retrieved from the\r\nDawn JWST Archive
  (DJA). DJA is an initiative of the Cosmic\r\nDawn Center (DAWN), which is funded
  by the Danish National\r\nResearch Foundation under grant DNRF140.\r\nRSE acknowledges
  generous financial support from the Peter\r\nand Patricia Gruber Foundation. YF
  acknowledgessupportsfrom\r\nJSPS KAKENHI Grant Numbers JP22K21349 and JP23K13149.\r\nThis
  work has received funding from the Swiss State Secretariat\r\nfor Education, Research
  and Innovation (SERI) under contract\r\nnumber MB22.00072, as well as from the Swiss
  National Science\r\nFoundation (SNSF) through project grant 200020_207349."
article_number: stag701
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Guido
  full_name: Roberts-Borsani, Guido
  last_name: Roberts-Borsani
- first_name: Pascal A
  full_name: Oesch, Pascal A
  last_name: Oesch
- first_name: Richard
  full_name: Ellis, Richard
  last_name: Ellis
- first_name: Andrea
  full_name: Weibel, Andrea
  last_name: Weibel
- first_name: Emma
  full_name: Giovinazzo, Emma
  last_name: Giovinazzo
- first_name: Rychard
  full_name: Bouwens, Rychard
  last_name: Bouwens
- first_name: Pratika
  full_name: Dayal, Pratika
  last_name: Dayal
- first_name: Adriano
  full_name: Fontana, Adriano
  last_name: Fontana
- first_name: Kasper E
  full_name: Heintz, Kasper E
  last_name: Heintz
- first_name: Jorryt J
  full_name: Matthee, Jorryt J
  id: 7439a258-f3c0-11ec-9501-9df22fe06720
  last_name: Matthee
  orcid: 0000-0003-2871-127X
- first_name: Romain A
  full_name: Meyer, Romain A
  last_name: Meyer
- first_name: Laura
  full_name: Pentericci, Laura
  last_name: Pentericci
- first_name: Alice
  full_name: Shapley, Alice
  last_name: Shapley
- first_name: Sandro
  full_name: Tacchella, Sandro
  last_name: Tacchella
- first_name: Tommaso
  full_name: Treu, Tommaso
  last_name: Treu
- first_name: Fabian
  full_name: Walter, Fabian
  last_name: Walter
- first_name: Hakim
  full_name: Atek, Hakim
  last_name: Atek
- first_name: Sownak
  full_name: Bose, Sownak
  last_name: Bose
- first_name: Marco
  full_name: Castellano, Marco
  last_name: Castellano
- first_name: Yoshinobu
  full_name: Fudamoto, Yoshinobu
  last_name: Fudamoto
- first_name: Takahiro
  full_name: Morishita, Takahiro
  last_name: Morishita
- first_name: Rohan P
  full_name: Naidu, Rohan P
  last_name: Naidu
- first_name: Ryan L
  full_name: Sanders, Ryan L
  last_name: Sanders
- first_name: Arjen
  full_name: van der Wel, Arjen
  last_name: van der Wel
citation:
  ama: 'Roberts-Borsani G, Oesch PA, Ellis R, et al. JWST spectroscopic insights into
    the diversity of galaxies in the first 500 Myr: Short-lived snapshots along a
    common evolutionary pathway. <i>Monthly Notices of the Royal Astronomical Society</i>.
    2026;548(3). doi:<a href="https://doi.org/10.1093/mnras/stag701">10.1093/mnras/stag701</a>'
  apa: 'Roberts-Borsani, G., Oesch, P. A., Ellis, R., Weibel, A., Giovinazzo, E.,
    Bouwens, R., … van der Wel, A. (2026). JWST spectroscopic insights into the diversity
    of galaxies in the first 500 Myr: Short-lived snapshots along a common evolutionary
    pathway. <i>Monthly Notices of the Royal Astronomical Society</i>. Oxford University
    Press. <a href="https://doi.org/10.1093/mnras/stag701">https://doi.org/10.1093/mnras/stag701</a>'
  chicago: 'Roberts-Borsani, Guido, Pascal A Oesch, Richard Ellis, Andrea Weibel,
    Emma Giovinazzo, Rychard Bouwens, Pratika Dayal, et al. “JWST Spectroscopic Insights
    into the Diversity of Galaxies in the First 500 Myr: Short-Lived Snapshots along
    a Common Evolutionary Pathway.” <i>Monthly Notices of the Royal Astronomical Society</i>.
    Oxford University Press, 2026. <a href="https://doi.org/10.1093/mnras/stag701">https://doi.org/10.1093/mnras/stag701</a>.'
  ieee: 'G. Roberts-Borsani <i>et al.</i>, “JWST spectroscopic insights into the diversity
    of galaxies in the first 500 Myr: Short-lived snapshots along a common evolutionary
    pathway,” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 548,
    no. 3. Oxford University Press, 2026.'
  ista: 'Roberts-Borsani G, Oesch PA, Ellis R, Weibel A, Giovinazzo E, Bouwens R,
    Dayal P, Fontana A, Heintz KE, Matthee JJ, Meyer RA, Pentericci L, Shapley A,
    Tacchella S, Treu T, Walter F, Atek H, Bose S, Castellano M, Fudamoto Y, Morishita
    T, Naidu RP, Sanders RL, van der Wel A. 2026. JWST spectroscopic insights into
    the diversity of galaxies in the first 500 Myr: Short-lived snapshots along a
    common evolutionary pathway. Monthly Notices of the Royal Astronomical Society.
    548(3), stag701.'
  mla: 'Roberts-Borsani, Guido, et al. “JWST Spectroscopic Insights into the Diversity
    of Galaxies in the First 500 Myr: Short-Lived Snapshots along a Common Evolutionary
    Pathway.” <i>Monthly Notices of the Royal Astronomical Society</i>, vol. 548,
    no. 3, stag701, Oxford University Press, 2026, doi:<a href="https://doi.org/10.1093/mnras/stag701">10.1093/mnras/stag701</a>.'
  short: G. Roberts-Borsani, P.A. Oesch, R. Ellis, A. Weibel, E. Giovinazzo, R. Bouwens,
    P. Dayal, A. Fontana, K.E. Heintz, J.J. Matthee, R.A. Meyer, L. Pentericci, A.
    Shapley, S. Tacchella, T. Treu, F. Walter, H. Atek, S. Bose, M. Castellano, Y.
    Fudamoto, T. Morishita, R.P. Naidu, R.L. Sanders, A. van der Wel, Monthly Notices
    of the Royal Astronomical Society 548 (2026).
date_created: 2026-05-20T14:34:29Z
date_published: 2026-05-01T00:00:00Z
date_updated: 2026-05-21T06:16:04Z
day: '01'
ddc:
- '520'
department:
- _id: JoMa
doi: 10.1093/mnras/stag701
external_id:
  arxiv:
  - '2508.21708'
file:
- access_level: open_access
  checksum: b8f52c6fc5e06b3a505310e7d5898ecf
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  date_created: 2026-05-21T06:14:23Z
  date_updated: 2026-05-21T06:14:23Z
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file_date_updated: 2026-05-21T06:14:23Z
has_accepted_license: '1'
intvolume: '       548'
issue: '3'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
  eissn:
  - 1365-2966
  issn:
  - 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'JWST spectroscopic insights into the diversity of galaxies in the first 500
  Myr: Short-lived snapshots along a common evolutionary pathway'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 548
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21899'
abstract:
- lang: eng
  text: Cell extrusion is an essential mechanism for controlling cell density in epithelial
    tissues. Another essential element of epithelia is curvature, which is required
    to achieve complex shapes, like in the lung or intestine. Here, we introduce a
    three-dimensional bubbly vertex model to study the interplay between extrusion
    and curvature. We find a generic cellular bulging instability at topological defects,
    which is much stronger than for standard vertex models. Analyzing cell shapes
    in three-dimensional imaging data of spherical mouse colon organoids, we infer
    that pentagonal cells have an increased basal interfacial tension, suggesting
    that cells at topological defects react to the different force conditions. Using
    the bubbly vertex model, we show that such basal tensions stabilize against the
    predicted instability and result in better cell shape control than tissue-scale
    mechanisms such as lumen pressure and spontaneous curvature. Our theory suggests
    that epithelial curvature naturally leads to bulged and extrusionlike cell shapes
    because the interfacial curvature of individual cells at the defects strongly
    amplifies buckling effected by tissue-scale topological defects in elastic sheets.
    Our results highlight the complex interplay of forces across scales in three-dimensional
    tissue organization.
acknowledgement: O. M. D., M. B., and U.S. S. acknowledge support from the Max Planck
  School Matter to Life, with funding by the German Federal Ministry of Education
  and Research (BMBF), the Dieter Schwarz Foundation, and the Max Planck Society.
  M. B. and U.S. S. acknowledge support from the cluster of excellence 3DMM2O (EXC
  2082/1-390761711 and EXC 2082/2-390761711) funded by the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation). The authors acknowledge the data storage service
  SDS@hd supported by the Ministry of Science, Research and the Arts Baden-Württemberg
  (MWK) and the DFG through Grant No. INST 35/1503-1 FUGG. For the publication fee
  we acknowledge financial support by Heidelberg University. O. M. D. thanks Edouard
  Hannezo for valuable discussions. U.S. S. is a member of the Interdisciplinary Center
  for Scientific Computing (IWR) at Heidelberg.
article_number: '021023'
article_processing_charge: Yes
article_type: original
author:
- first_name: Oliver M
  full_name: Drozdowski, Oliver M
  id: cd4ed792-b872-11ef-bb90-b7b3a3f62f75
  last_name: Drozdowski
- first_name: Büşra
  full_name: "Kocameşe-Tamgac\U0001D6A4, Büşra"
  last_name: "Kocameşe-Tamgac\U0001D6A4"
- first_name: Kim E.
  full_name: Boonekamp, Kim E.
  last_name: Boonekamp
- first_name: Michael
  full_name: Boutros, Michael
  last_name: Boutros
- first_name: Ulrich S.
  full_name: Schwarz, Ulrich S.
  last_name: Schwarz
citation:
  ama: "Drozdowski OM, Kocameşe-Tamgac\U0001D6A4 B, Boonekamp KE, Boutros M, Schwarz
    US. Cell bulging and extrusion in a three-dimensional bubbly vertex model for
    curved epithelial sheets. <i>Physical Review X</i>. 2026;16(2). doi:<a href=\"https://doi.org/10.1103/x82g-cq7n\">10.1103/x82g-cq7n</a>"
  apa: "Drozdowski, O. M., Kocameşe-Tamgac\U0001D6A4, B., Boonekamp, K. E., Boutros,
    M., &#38; Schwarz, U. S. (2026). Cell bulging and extrusion in a three-dimensional
    bubbly vertex model for curved epithelial sheets. <i>Physical Review X</i>. American
    Physical Society. <a href=\"https://doi.org/10.1103/x82g-cq7n\">https://doi.org/10.1103/x82g-cq7n</a>"
  chicago: "Drozdowski, Oliver M, Büşra Kocameşe-Tamgac\U0001D6A4, Kim E. Boonekamp,
    Michael Boutros, and Ulrich S. Schwarz. “Cell Bulging and Extrusion in a Three-Dimensional
    Bubbly Vertex Model for Curved Epithelial Sheets.” <i>Physical Review X</i>. American
    Physical Society, 2026. <a href=\"https://doi.org/10.1103/x82g-cq7n\">https://doi.org/10.1103/x82g-cq7n</a>."
  ieee: "O. M. Drozdowski, B. Kocameşe-Tamgac\U0001D6A4, K. E. Boonekamp, M. Boutros,
    and U. S. Schwarz, “Cell bulging and extrusion in a three-dimensional bubbly vertex
    model for curved epithelial sheets,” <i>Physical Review X</i>, vol. 16, no. 2.
    American Physical Society, 2026."
  ista: "Drozdowski OM, Kocameşe-Tamgac\U0001D6A4 B, Boonekamp KE, Boutros M, Schwarz
    US. 2026. Cell bulging and extrusion in a three-dimensional bubbly vertex model
    for curved epithelial sheets. Physical Review X. 16(2), 021023."
  mla: Drozdowski, Oliver M., et al. “Cell Bulging and Extrusion in a Three-Dimensional
    Bubbly Vertex Model for Curved Epithelial Sheets.” <i>Physical Review X</i>, vol.
    16, no. 2, 021023, American Physical Society, 2026, doi:<a href="https://doi.org/10.1103/x82g-cq7n">10.1103/x82g-cq7n</a>.
  short: "O.M. Drozdowski, B. Kocameşe-Tamgac\U0001D6A4, K.E. Boonekamp, M. Boutros,
    U.S. Schwarz, Physical Review X 16 (2026)."
date_created: 2026-05-20T14:35:57Z
date_published: 2026-04-30T00:00:00Z
date_updated: 2026-05-21T06:08:11Z
day: '30'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1103/x82g-cq7n
file:
- access_level: open_access
  checksum: a90e905968648ac4425c256de901e9c3
  content_type: application/pdf
  creator: dernst
  date_created: 2026-05-21T06:05:49Z
  date_updated: 2026-05-21T06:05:49Z
  file_id: '21901'
  file_name: 2026_PhysicalReviewX_Drozdowski.pdf
  file_size: 5603164
  relation: main_file
  success: 1
file_date_updated: 2026-05-21T06:05:49Z
has_accepted_license: '1'
intvolume: '        16'
issue: '2'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: Physical Review X
publication_identifier:
  issn:
  - 2160-3308
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Cell bulging and extrusion in a three-dimensional bubbly vertex model for curved
  epithelial sheets
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 16
year: '2026'
...
