---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21849'
abstract:
- lang: eng
  text: The development of complex tissues relies on the precise assignment of cell
    identity. At the molecular scale, this process depends on the deposition of epigenetic
    modifications—such as methylation—that are regulated by complex biochemical networks
    and occur at specific regions on the DNA and chromatin. Here we show that despite
    the complexity of epigenetic regulation, dynamical scaling and self-similarity
    of DNA methylation marks emerge in embryonic development. Drawing on single-cell
    multi-omics experiments, super-resolution microscopy and statistical physics,
    we demonstrate that these phenomena originate in dynamical feedback between DNA
    methylation and the formation of nanoscale dynamic chromatin aggregates. These
    nanoscale processes lead to genome-wide increase in DNA methylation marks following
    a power law and self-similar correlation functions. Using this framework, we identify
    methylation patterns that precede gene expression changes in embryonic symmetry
    breaking. Our work identifies linear sequencing measurements as a laboratory to
    study mesoscopic biophysical processes in vivo.
acknowledgement: We thank all members of the W.R. and S.R. laboratories, F. Piazza,
  B. D. Simons, and F. Jülicher for helpful discussions. We thank M. Ciarchi for providing
  annotations for the chromatin compartments. S.R. is a member of the Center for Nano
  Science (CeNS). This project has received funding from the European Research Council
  (ERC) under the European Union’s Horizon 2020 research and innovation programme
  (grant agreement number 950349). Research in W.R.’s laboratory was supported by
  the Biotechnology and Biological Sciences Research Council (BB/K010867/1), Wellcome
  (095645/Z/11/Z) and the European Research Council (ERC) under the European Union’s
  Horizon 2020 research and innovation programme (EpiCell lineage 882798). F.O. received
  funding from the European Union’s Horizon 2020 research and innovation programme
  under the Marie Skłodowska-Curie grant agreement number 101034413. Open access funding
  provided by Max Planck Society.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fabrizio
  full_name: Olmeda, Fabrizio
  id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689
  last_name: Olmeda
- first_name: Tim
  full_name: Lohoff, Tim
  last_name: Lohoff
- first_name: Ioannis
  full_name: Kafetzopoulos, Ioannis
  last_name: Kafetzopoulos
- first_name: Stephen J.
  full_name: Clark, Stephen J.
  last_name: Clark
- first_name: Laura
  full_name: Benson, Laura
  last_name: Benson
- first_name: Fatima
  full_name: Santos, Fatima
  last_name: Santos
- first_name: Felix
  full_name: Krueger, Felix
  last_name: Krueger
- first_name: Simon
  full_name: Walker, Simon
  last_name: Walker
- first_name: Wolf
  full_name: Reik, Wolf
  last_name: Reik
- first_name: Steffen
  full_name: Rulands, Steffen
  last_name: Rulands
citation:
  ama: Olmeda F, Lohoff T, Kafetzopoulos I, et al. Scaling and self-similarity in
    the formation of the embryonic epigenome. <i>Nature Physics</i>. 2026;22:931-940.
    doi:<a href="https://doi.org/10.1038/s41567-026-03263-x">10.1038/s41567-026-03263-x</a>
  apa: Olmeda, F., Lohoff, T., Kafetzopoulos, I., Clark, S. J., Benson, L., Santos,
    F., … Rulands, S. (2026). Scaling and self-similarity in the formation of the
    embryonic epigenome. <i>Nature Physics</i>. Springer Nature. <a href="https://doi.org/10.1038/s41567-026-03263-x">https://doi.org/10.1038/s41567-026-03263-x</a>
  chicago: Olmeda, Fabrizio, Tim Lohoff, Ioannis Kafetzopoulos, Stephen J. Clark,
    Laura Benson, Fatima Santos, Felix Krueger, Simon Walker, Wolf Reik, and Steffen
    Rulands. “Scaling and Self-Similarity in the Formation of the Embryonic Epigenome.”
    <i>Nature Physics</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41567-026-03263-x">https://doi.org/10.1038/s41567-026-03263-x</a>.
  ieee: F. Olmeda <i>et al.</i>, “Scaling and self-similarity in the formation of
    the embryonic epigenome,” <i>Nature Physics</i>, vol. 22. Springer Nature, pp.
    931–940, 2026.
  ista: Olmeda F, Lohoff T, Kafetzopoulos I, Clark SJ, Benson L, Santos F, Krueger
    F, Walker S, Reik W, Rulands S. 2026. Scaling and self-similarity in the formation
    of the embryonic epigenome. Nature Physics. 22, 931–940.
  mla: Olmeda, Fabrizio, et al. “Scaling and Self-Similarity in the Formation of the
    Embryonic Epigenome.” <i>Nature Physics</i>, vol. 22, Springer Nature, 2026, pp.
    931–40, doi:<a href="https://doi.org/10.1038/s41567-026-03263-x">10.1038/s41567-026-03263-x</a>.
  short: F. Olmeda, T. Lohoff, I. Kafetzopoulos, S.J. Clark, L. Benson, F. Santos,
    F. Krueger, S. Walker, W. Reik, S. Rulands, Nature Physics 22 (2026) 931–940.
das_tickbox: '1'
dataavailabilitystatement: All sequencing datasets reported in this paper are available
  on Gene Expression Omnibus (GEO) under accession GSE166226. STORM localization data
  are available on Zenodo (https://doi.org/10.5281/zenodo.18965309)57. Raw images
  are available upon request. Code for computing the correlation functions and STORM
  analysis are available via GitHub at https://github.com/srulands/inference_of_spatio-temporal_processes.
date_created: 2026-05-10T22:02:16Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-27T13:56:09Z
day: '01'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41567-026-03263-x
ec_funded: 1
external_id:
  pmid:
  - '42318073'
file:
- access_level: open_access
  checksum: 58e7734f1ebaf6def642140cb489f08f
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  creator: dernst
  date_created: 2026-07-27T13:54:58Z
  date_updated: 2026-07-27T13:54:58Z
  file_id: '22591'
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  file_size: 7932222
  relation: main_file
  success: 1
file_date_updated: 2026-07-27T13:54:58Z
has_accepted_license: '1'
intvolume: '        22'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '06'
oa: 1
oa_version: Published Version
page: 931-940
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Nature Physics
publication_identifier:
  eissn:
  - 1745-2481
  issn:
  - 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Scaling and self-similarity in the formation of the embryonic epigenome
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21883'
abstract:
- lang: eng
  text: Three-dimensional (3D) printing has rapidly developed from a niche hobbyist
    activity into a widely accessible and indispensable technology across multiple
    scientific disciplines. Within microscopy, optical engineering laboratories and
    imaging core facilities, 3D printing enables creating customised solutions for
    sample holders, optical components and everyday laboratory tools that traditionally
    required specialised machining. By providing rapid prototyping, low-cost production
    and reproducibility, 3D printing facilitates innovation and efficiency in facility
    operations. This article provides a perspective on the possibilities, challenges,
    and practical aspects of implementing 3D printing within microscopy core facilities.
    Instead of providing technical review about 3D printing, we focus on service organisation,
    user engagement, resource management and community-driven repositories for design
    dissemination. Our aim is to share insights with those considering the implementation
    of 3D printing as a service for developing add-on components to ease the operation
    of different aspects of the machine-park driven services and those who are managing
    advanced instrumentation within research groups.
acknowledged_ssus:
- _id: Bio
- _id: M-Shop
acknowledgement: "This work was supported by the Scientific Service Units (SSU) of
  Institute of Science and Technology Austria (ISTA) through resources provided by
  the Imaging & Optics Facility (IOF) and the MiBa Machine Shop. Specifically; Robert
  Hauschild (IOF), sharing designs, insights and pioneering 3D printing activities
  at the Imaging and Optics Facility; Bernhard Hochreiter (IOF), for support and testing
  of anoxic chamber. We also thank Ana Rita Carvalho Faria and Oliver Biehlmaier (Biozentrum
  University of Basel, Imaging Core Facility) for sharing the design of the adopted
  power meter.\r\nOpen Access funding provided by Institute of Science and Technology
  Austria."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Mohammad
  full_name: Goudarzi, Mohammad
  id: 3384113A-F248-11E8-B48F-1D18A9856A87
  last_name: Goudarzi
- first_name: Maximilian
  full_name: Schuster, Maximilian
  id: 37e65def-d415-11eb-ae59-a7b67be103db
  last_name: Schuster
- first_name: Arthur
  full_name: Milberger, Arthur
  last_name: Milberger
- first_name: Manuel
  full_name: Gunkel, Manuel
  last_name: Gunkel
- first_name: Stefan
  full_name: Terjung, Stefan
  last_name: Terjung
- first_name: Gabriel
  full_name: Krens, Gabriel
  id: 2B819732-F248-11E8-B48F-1D18A9856A87
  last_name: Krens
  orcid: 0000-0003-4761-5996
citation:
  ama: Goudarzi M, Schuster M, Milberger A, Gunkel M, Terjung S, Krens G. 3D printing
    in core facilities – Low pain, high gain. <i>Journal of Microscopy</i>. 2026;302(3):382-395.
    doi:<a href="https://doi.org/10.1111/jmi.70106">10.1111/jmi.70106</a>
  apa: Goudarzi, M., Schuster, M., Milberger, A., Gunkel, M., Terjung, S., &#38; Krens,
    G. (2026). 3D printing in core facilities – Low pain, high gain. <i>Journal of
    Microscopy</i>. Wiley. <a href="https://doi.org/10.1111/jmi.70106">https://doi.org/10.1111/jmi.70106</a>
  chicago: Goudarzi, Mohammad, Maximilian Schuster, Arthur Milberger, Manuel Gunkel,
    Stefan Terjung, and Gabriel Krens. “3D Printing in Core Facilities – Low Pain,
    High Gain.” <i>Journal of Microscopy</i>. Wiley, 2026. <a href="https://doi.org/10.1111/jmi.70106">https://doi.org/10.1111/jmi.70106</a>.
  ieee: M. Goudarzi, M. Schuster, A. Milberger, M. Gunkel, S. Terjung, and G. Krens,
    “3D printing in core facilities – Low pain, high gain,” <i>Journal of Microscopy</i>,
    vol. 302, no. 3. Wiley, pp. 382–395, 2026.
  ista: Goudarzi M, Schuster M, Milberger A, Gunkel M, Terjung S, Krens G. 2026. 3D
    printing in core facilities – Low pain, high gain. Journal of Microscopy. 302(3),
    382–395.
  mla: Goudarzi, Mohammad, et al. “3D Printing in Core Facilities – Low Pain, High
    Gain.” <i>Journal of Microscopy</i>, vol. 302, no. 3, Wiley, 2026, pp. 382–95,
    doi:<a href="https://doi.org/10.1111/jmi.70106">10.1111/jmi.70106</a>.
  short: M. Goudarzi, M. Schuster, A. Milberger, M. Gunkel, S. Terjung, G. Krens,
    Journal of Microscopy 302 (2026) 382–395.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-05-17T22:02:11Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-27T14:02:46Z
day: '01'
ddc:
- '600'
department:
- _id: Bio
doi: 10.1111/jmi.70106
external_id:
  pmid:
  - '42104760'
file:
- access_level: open_access
  checksum: 06dfad92b1465ed614a1201b4129960a
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  creator: dernst
  date_created: 2026-07-27T14:01:34Z
  date_updated: 2026-07-27T14:01:34Z
  file_id: '22593'
  file_name: 2026_JourMicroscopy_Goudarzi.pdf
  file_size: 4625767
  relation: main_file
  success: 1
file_date_updated: 2026-07-27T14:01:34Z
has_accepted_license: '1'
intvolume: '       302'
issue: '3'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 382-395
pmid: 1
publication: Journal of Microscopy
publication_identifier:
  eissn:
  - 1365-2818
  issn:
  - 0022-2720
publication_status: published
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: 3D printing in core facilities – Low pain, high gain
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 302
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21872'
abstract:
- lang: eng
  text: Magneto-optic Kerr effect (MOKE) is a powerful probe of broken time-reversal
    symmetry (T), typically used to study ferromagnets. While MOKE has been observed
    in some antiferromagnets (AFMs) with vanishing magnetization, it is often associated
    with structures whose symmetry is lower than basic collinear, bipartite order.
    In contrast, theory predicts a mechanism for MOKE intrinsic to all AFMs of A-type,
    i.e. layered AFMs in which ferromagnetic layers are antiferromagnetically aligned.
    Here we report the experimental confirmation of this mechanism in a bulk AFM.
    We achieve this by measuring the imaginary component of MOKE as a function of
    photon energy in MnBi2Te4, an A-type AFM where T is preserved in combination with
    a translation, and comparing the experimental results with model calculations.
    Our model suggests that observable MOKE should be expected in all collinear A-type
    AFMs with out-of-plane spin order, thus enabling optical detection of AFM domains
    and expanding the scope of MOKE to few-layer AFMs.
acknowledgement: We thank Christine Kuntscher for providing optical conductivity and
  reflectance data published in ref. 33, and Nicola Spaldin, Joel Moore and Bevin
  Huang for useful discussions. V.S. and J.O. received support from the Gordon and
  Betty Moore Foundation’s EPiQS Initiative through Grant GBMF4537 awarded to J.O.
  at UC Berkeley. Experimental and theoretical work at LBNL and UC Berkeley was funded
  by the Quantum Materials (KC2202) program under the U.S. Department of Energy, Office
  of Science, Office of Basic Energy Sciences, Materials Sciences and Engineering
  Division under Contract No. DE-AC02-05CH11231. Work at the University of Kansas
  was supported by the U.S. Department of Energy, Office of Science, Basic Energy
  Sciences, EPSCoR, and Materials Sciences and Engineering Division under Award No.
  DE-SC0025319. Parts of device fabrication were performed in the KU Nanofabrication
  Facility, which is supported by the National Institutes of Health NIGMS P30GM145499.
  Work at ORNL was supported by the U. S. Department of Energy, Office of Science,
  Basic Energy Sciences, Materials Sciences and Engineering Division. For the DFT
  calculations we used resources provided by the Swedish National Infrastructure for
  Computing (SNIC) at C3SE. We acknowledge support from the US National Science Foundation
  (NSF) Grant Number 2201516 under the Accelnet program of Office of International
  Science and Engineering (OISE). This publication is funded in part by a QuantEmX
  grant from ICAM and the Gordon and Betty Moore Foundation through Grant GBMF9616
  to S. K.
article_number: '7364'
article_processing_charge: Yes
article_type: original
arxiv: 1
author:
- first_name: Veronika
  full_name: Sunko, Veronika
  id: 23cb1cf6-2c7a-11ef-91a4-f72fc19f20b3
  last_name: Sunko
  orcid: 0000-0003-2724-3523
- first_name: Salman
  full_name: Ahsanullah, Salman
  last_name: Ahsanullah
- first_name: Vivek
  full_name: Jain, Vivek
  last_name: Jain
- first_name: Sophie
  full_name: Weber, Sophie
  last_name: Weber
- first_name: Sivaloganathan
  full_name: Kumaran, Sivaloganathan
  last_name: Kumaran
- first_name: Jiaqiang
  full_name: Yan, Jiaqiang
  last_name: Yan
- first_name: Joseph
  full_name: Orenstein, Joseph
  last_name: Orenstein
- first_name: Dmitry
  full_name: Ovchinnikov, Dmitry
  last_name: Ovchinnikov
citation:
  ama: Sunko V, Ahsanullah S, Jain V, et al. Magneto-optical Kerr effect in an A-type
    antiferromagnet. <i>Nature Communications</i>. 2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-72577-4">10.1038/s41467-026-72577-4</a>
  apa: Sunko, V., Ahsanullah, S., Jain, V., Weber, S., Kumaran, S., Yan, J., … Ovchinnikov,
    D. (2026). Magneto-optical Kerr effect in an A-type antiferromagnet. <i>Nature
    Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-026-72577-4">https://doi.org/10.1038/s41467-026-72577-4</a>
  chicago: Sunko, Veronika, Salman Ahsanullah, Vivek Jain, Sophie Weber, Sivaloganathan
    Kumaran, Jiaqiang Yan, Joseph Orenstein, and Dmitry Ovchinnikov. “Magneto-Optical
    Kerr Effect in an A-Type Antiferromagnet.” <i>Nature Communications</i>. Springer
    Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-72577-4">https://doi.org/10.1038/s41467-026-72577-4</a>.
  ieee: V. Sunko <i>et al.</i>, “Magneto-optical Kerr effect in an A-type antiferromagnet,”
    <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.
  ista: Sunko V, Ahsanullah S, Jain V, Weber S, Kumaran S, Yan J, Orenstein J, Ovchinnikov
    D. 2026. Magneto-optical Kerr effect in an A-type antiferromagnet. Nature Communications.
    17, 7364.
  mla: Sunko, Veronika, et al. “Magneto-Optical Kerr Effect in an A-Type Antiferromagnet.”
    <i>Nature Communications</i>, vol. 17, 7364, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-72577-4">10.1038/s41467-026-72577-4</a>.
  short: V. Sunko, S. Ahsanullah, V. Jain, S. Weber, S. Kumaran, J. Yan, J. Orenstein,
    D. Ovchinnikov, Nature Communications 17 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: The datasets generated and analyzed during the study of
  “Magneto-optical Kerr effect in an A-type antiferromagnet" are available in the
  ISTA REx repository with https://doi.org/10.15479/AT-ISTA-21422.
date_created: 2026-05-12T21:31:27Z
date_published: 2026-07-27T00:00:00Z
date_updated: 2026-07-27T13:59:27Z
day: '27'
ddc:
- '530'
department:
- _id: VeSu
doi: 10.1038/s41467-026-72577-4
external_id:
  arxiv:
  - '2504.16167'
file:
- access_level: open_access
  checksum: bde19c4342933c05fe801c2bef7dc732
  content_type: application/pdf
  creator: dernst
  date_created: 2026-07-27T13:58:06Z
  date_updated: 2026-07-27T13:58:06Z
  file_id: '22592'
  file_name: 2026_NatureComm_Sunko.pdf
  file_size: 1054779
  relation: main_file
  success: 1
file_date_updated: 2026-07-27T13:58:06Z
has_accepted_license: '1'
intvolume: '        17'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
  record:
  - id: '21422'
    relation: research_data
    status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Magneto-optical Kerr effect in an A-type antiferromagnet
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_type: closed access
_id: '21950'
abstract:
- lang: eng
  text: One Health initiatives are modern paradigms for research and health care practices
    in various fields. Concrete definitions of the One Health framework, however,
    remain heterogeneous, leading to conceptual problems and uncertainties in the
    application of the framework. This article discusses several approaches to the
    One Health concept, and their associated consequences, with special focus on animal
    experimentation. The first issue addressed is how One Health should be defined,
    as well as what (and who) should be considered within a One Health approach. In
    order to shed further light on this, we explore the history of animals in biomedical
    science, highlighting historical milestones in the use of animal models, as well
    as the development and current state of ethical considerations in the field of
    animal experimentation. The second issue comes with the inclusion of animal experimentation
    per se as part of the One Health concept. Therefore, particular attention is paid
    to bioethical principles and the resulting problems that can arise when applying
    them to the One Health concept. Arguments such as the idea of inequality between
    humans and non-human animals, and the premise that all actions are done for the
    benefit of humans, are raised and then used to explore the question of whether
    the One Health concept is compatible with existing bioethical principles. Based
    on the bioethical principles of protecting the environment, the biodiversity and
    biosphere, this paper seeks an inclusive perspective of the One Health concept.
    Successful solutions will be based on this concept, which embraces all living
    beings. The authors conclude that a multispecies ethics approach could help create
    a more ethical ecosystem that is aligned with the wellbeing of all life on a shared
    planet.
article_processing_charge: No
article_type: original
author:
- first_name: Yesim Isil
  full_name: Ulman, Yesim Isil
  last_name: Ulman
- first_name: Nikos
  full_name: Kostomitsopoulos, Nikos
  last_name: Kostomitsopoulos
- first_name: Samuel
  full_name: Camenzind, Samuel
  last_name: Camenzind
- first_name: Maria
  full_name: Kitsara, Maria
  last_name: Kitsara
- first_name: Ilja Richard
  full_name: Pavone, Ilja Richard
  last_name: Pavone
- first_name: Sophie
  full_name: Schober, Sophie
  id: 80b0a0ef-4b9f-11ec-b119-8d9d94c4a1d8
  last_name: Schober
citation:
  ama: 'Ulman YI, Kostomitsopoulos N, Camenzind S, Kitsara M, Pavone IR, Schober S.
    Emerging bioethical conflicts: One Health and animal experimentation. <i>Alternatives
    to Laboratory Animals</i>. 2026;54(4):226-235. doi:<a href="https://doi.org/10.1177/02611929261453330">10.1177/02611929261453330</a>'
  apa: 'Ulman, Y. I., Kostomitsopoulos, N., Camenzind, S., Kitsara, M., Pavone, I.
    R., &#38; Schober, S. (2026). Emerging bioethical conflicts: One Health and animal
    experimentation. <i>Alternatives to Laboratory Animals</i>. SAGE Publications.
    <a href="https://doi.org/10.1177/02611929261453330">https://doi.org/10.1177/02611929261453330</a>'
  chicago: 'Ulman, Yesim Isil, Nikos Kostomitsopoulos, Samuel Camenzind, Maria Kitsara,
    Ilja Richard Pavone, and Sophie Schober. “Emerging Bioethical Conflicts: One Health
    and Animal Experimentation.” <i>Alternatives to Laboratory Animals</i>. SAGE Publications,
    2026. <a href="https://doi.org/10.1177/02611929261453330">https://doi.org/10.1177/02611929261453330</a>.'
  ieee: 'Y. I. Ulman, N. Kostomitsopoulos, S. Camenzind, M. Kitsara, I. R. Pavone,
    and S. Schober, “Emerging bioethical conflicts: One Health and animal experimentation,”
    <i>Alternatives to Laboratory Animals</i>, vol. 54, no. 4. SAGE Publications,
    pp. 226–235, 2026.'
  ista: 'Ulman YI, Kostomitsopoulos N, Camenzind S, Kitsara M, Pavone IR, Schober
    S. 2026. Emerging bioethical conflicts: One Health and animal experimentation.
    Alternatives to Laboratory Animals. 54(4), 226–235.'
  mla: 'Ulman, Yesim Isil, et al. “Emerging Bioethical Conflicts: One Health and Animal
    Experimentation.” <i>Alternatives to Laboratory Animals</i>, vol. 54, no. 4, SAGE
    Publications, 2026, pp. 226–35, doi:<a href="https://doi.org/10.1177/02611929261453330">10.1177/02611929261453330</a>.'
  short: Y.I. Ulman, N. Kostomitsopoulos, S. Camenzind, M. Kitsara, I.R. Pavone, S.
    Schober, Alternatives to Laboratory Animals 54 (2026) 226–235.
corr_author: '1'
das_tickbox: '1'
date_created: 2026-06-07T22:01:36Z
date_published: 2026-07-01T00:00:00Z
date_updated: 2026-07-27T14:13:17Z
day: '01'
department:
- _id: PreCl
doi: 10.1177/02611929261453330
external_id:
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  - '42185081'
intvolume: '        54'
issue: '4'
language:
- iso: eng
month: '07'
oa_version: None
page: 226-235
pmid: 1
publication: Alternatives to Laboratory Animals
publication_identifier:
  eissn:
  - 2632-3559
  issn:
  - 0261-1929
publication_status: published
publisher: SAGE Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Emerging bioethical conflicts: One Health and animal experimentation'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 54
year: '2026'
...
---
OA_type: closed access
_id: '21900'
abstract:
- lang: eng
  text: Individually silencing 125 fruit fly genes reveals opposing fitness effects
    of mutations between females and males, as well as between germline and somatic
    tissues.
article_processing_charge: No
article_type: comment
author:
- first_name: Filip
  full_name: Ruzicka, Filip
  id: 347955dd-57b0-11ee-9095-c28bdd368f4b
  last_name: Ruzicka
citation:
  ama: Ruzicka F. Reverse genetics of sexual antagonism. <i>Nature Ecology &#38; Evolution</i>.
    2026;10:1035-1036. doi:<a href="https://doi.org/10.1038/s41559-026-03036-y">10.1038/s41559-026-03036-y</a>
  apa: Ruzicka, F. (2026). Reverse genetics of sexual antagonism. <i>Nature Ecology
    &#38; Evolution</i>. Springer Nature. <a href="https://doi.org/10.1038/s41559-026-03036-y">https://doi.org/10.1038/s41559-026-03036-y</a>
  chicago: Ruzicka, Filip. “Reverse Genetics of Sexual Antagonism.” <i>Nature Ecology
    &#38; Evolution</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41559-026-03036-y">https://doi.org/10.1038/s41559-026-03036-y</a>.
  ieee: F. Ruzicka, “Reverse genetics of sexual antagonism,” <i>Nature Ecology &#38;
    Evolution</i>, vol. 10. Springer Nature, pp. 1035–1036, 2026.
  ista: Ruzicka F. 2026. Reverse genetics of sexual antagonism. Nature Ecology &#38;
    Evolution. 10, 1035–1036.
  mla: Ruzicka, Filip. “Reverse Genetics of Sexual Antagonism.” <i>Nature Ecology
    &#38; Evolution</i>, vol. 10, Springer Nature, 2026, pp. 1035–36, doi:<a href="https://doi.org/10.1038/s41559-026-03036-y">10.1038/s41559-026-03036-y</a>.
  short: F. Ruzicka, Nature Ecology &#38; Evolution 10 (2026) 1035–1036.
corr_author: '1'
das_tickbox: '0'
date_created: 2026-05-20T14:36:45Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-27T14:05:02Z
day: '01'
department:
- _id: BeVi
doi: 10.1038/s41559-026-03036-y
external_id:
  pmid:
  - '42067637 '
intvolume: '        10'
language:
- iso: eng
month: '06'
oa_version: None
page: 1035-1036
pmid: 1
publication: Nature Ecology & Evolution
publication_identifier:
  eissn:
  - 2397-334X
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Reverse genetics of sexual antagonism
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2026'
...
---
OA_place: publisher
_id: '21957'
abstract:
- lang: eng
  text: "This thesis investigates algorithmic certification and approximation methods
    for degenerate semidefinite programs (SDPs) and the singular roots of polynomial
    systems. In the first part, we present a hybrid symbolic-numeric algorithm for
    certifying the feasibility of weakly feasible, degenerate SDPs. By reformulating
    linear matrix inequalities (LMIs) into a structured polynomial system via facial
    reduction and incidence varieties, we guarantee the existence of an isolated exact
    solution. This algebraic reduction enables the certification of maximum-rank numerical
    approximations using methods from algebraic geometry.\r\n\r\nIn the second part,
    we address the severe ill-conditioning and loss of quadratic convergence that
    plague standard path-tracking methods near isolated singular roots. To overcome
    this, we propose tracking algorithms that achieve superlinear convergence without
    the computational bloat characteristic of classical deflation techniques. By modeling
    the solution path as a generalized fractional Puiseux series, our approach combines
    an explicitly derived algebraic predictor with a localized hyperplane desingularization
    phase during the corrector step. Furthermore, we introduce a continuous path-limit
    method and an extension of the geometric sequence rule to directly extract exact
    fractional exponents. This bypasses traditional heuristic trial-and-error methods
    and explicitly accommodates sparse series expansions. Numerical experiments confirm
    that our method significantly reduces the cumulative number of matrix inversions
    while achieving high-accuracy root approximations, even for heavily degenerate
    systems exhibiting higher coranks."
acknowledgement: 'Funding: Vienna Graduate School on Computational Optimization (FWF),
  grant DOI: 10.55776/W1260.'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jeferson
  full_name: Zapata, Jeferson
  id: 00223538-AF8F-11E9-A4C7-F729E6697425
  last_name: Zapata
citation:
  ama: 'Zapata J. Overcoming degeneracy and singularity: Techniques for semidefinite
    programs and homotopy continuation endgames. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21957">10.15479/AT-ISTA-21957</a>'
  apa: 'Zapata, J. (2026). <i>Overcoming degeneracy and singularity: Techniques for
    semidefinite programs and homotopy continuation endgames</i>. Institute of Science
    and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21957">https://doi.org/10.15479/AT-ISTA-21957</a>'
  chicago: 'Zapata, Jeferson. “Overcoming Degeneracy and Singularity: Techniques for
    Semidefinite Programs and Homotopy Continuation Endgames.” Institute of Science
    and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21957">https://doi.org/10.15479/AT-ISTA-21957</a>.'
  ieee: 'J. Zapata, “Overcoming degeneracy and singularity: Techniques for semidefinite
    programs and homotopy continuation endgames,” Institute of Science and Technology
    Austria, 2026.'
  ista: 'Zapata J. 2026. Overcoming degeneracy and singularity: Techniques for semidefinite
    programs and homotopy continuation endgames. Institute of Science and Technology
    Austria.'
  mla: 'Zapata, Jeferson. <i>Overcoming Degeneracy and Singularity: Techniques for
    Semidefinite Programs and Homotopy Continuation Endgames</i>. Institute of Science
    and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21957">10.15479/AT-ISTA-21957</a>.'
  short: 'J. Zapata, Overcoming Degeneracy and Singularity: Techniques for Semidefinite
    Programs and Homotopy Continuation Endgames, Institute of Science and Technology
    Austria, 2026.'
corr_author: '1'
das_tickbox: '1'
date_created: 2026-06-08T13:29:52Z
date_published: 2026-06-09T00:00:00Z
date_updated: 2026-07-27T14:30:42Z
day: '09'
ddc:
- '500'
degree_awarded: PhD
department:
- _id: GradSch
- _id: VlKo
doi: 10.15479/AT-ISTA-21957
doi_confirm: '1'
file:
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  file_id: '21958'
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  date_created: 2026-06-10T13:33:25Z
  date_updated: 2026-06-10T13:33:25Z
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  file_name: 4_Final_Thesis_JZapata_REX.pdf
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  success: 1
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language:
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month: '06'
oa: 1
oa_version: Published Version
page: '89'
project:
- _id: 9B9290DE-BA93-11EA-9121-9846C619BF3A
  grant_number: W1260-N35
  name: Vienna Graduate School on Computational Optimization
publication_identifier:
  isbn:
  - 978-3-99078-079-4
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
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    status: public
status: public
supervisor:
- first_name: Vladimir
  full_name: Kolmogorov, Vladimir
  id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
  last_name: Kolmogorov
title: 'Overcoming degeneracy and singularity: Techniques for semidefinite programs
  and homotopy continuation endgames'
tmp:
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type: dissertation
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year: '2026'
...
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acknowledged_ssus:
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- _id: Bio
acknowledgement: "I would like to acknowledge the Austrian Academy of Sciences (ÖAW)
  and European\r\nResearch Executive Agency (REA) for funding my research (DOC ÖAW
  Fellowship\r\n26130, Horizon Europe BOLERO Project 101060393). "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
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  full_name: Riegler, Stefan
  id: FF6018E0-D806-11E9-8E43-0B14E6697425
  last_name: Riegler
  orcid: 0000-0003-3413-1343
citation:
  ama: 'Riegler S. Root system plasticity under nutrient limitation: Investigating
    hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. 2026.
    doi:<a href="https://doi.org/10.15479/AT-ISTA-21360">10.15479/AT-ISTA-21360</a>'
  apa: 'Riegler, S. (2026). <i>Root system plasticity under nutrient limitation: Investigating
    hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21360">https://doi.org/10.15479/AT-ISTA-21360</a>'
  chicago: 'Riegler, Stefan. “Root System Plasticity under Nutrient Limitation: Investigating
    Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species.” Institute
    of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21360">https://doi.org/10.15479/AT-ISTA-21360</a>.'
  ieee: 'S. Riegler, “Root system plasticity under nutrient limitation: Investigating
    hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species,” Institute
    of Science and Technology Austria, 2026.'
  ista: 'Riegler S. 2026. Root system plasticity under nutrient limitation: Investigating
    hormonal and molecular drivers in Arabidopsis thaliana and Coffea  species. Institute
    of Science and Technology Austria.'
  mla: 'Riegler, Stefan. <i>Root System Plasticity under Nutrient Limitation: Investigating
    Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species</i>.
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-21360">10.15479/AT-ISTA-21360</a>.'
  short: 'S. Riegler, Root System Plasticity under Nutrient Limitation: Investigating
    Hormonal and Molecular Drivers in Arabidopsis Thaliana and Coffea  Species, Institute
    of Science and Technology Austria, 2026.'
corr_author: '1'
das_tickbox: '1'
date_created: 2026-02-27T09:08:14Z
date_published: 2026-02-26T00:00:00Z
date_updated: 2026-07-27T14:30:08Z
day: '26'
ddc:
- '570'
- '575'
- '583'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/AT-ISTA-21360
doi_confirm: '1'
file:
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  date_updated: 2026-03-02T10:59:49Z
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file_date_updated: 2026-03-02T10:59:50Z
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language:
- iso: eng
license: https://creativecommons.org/licenses/by-sa/4.0/
month: '02'
oa_version: Published Version
page: '185'
project:
- _id: 34afa094-11ca-11ed-8bc3-a375845a59fb
  grant_number: '101060393'
  name: Breeding for coffee and cocoa root resilience in low input farming systems
    based on improved rootstocks
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '21363'
    relation: research_data
    status: public
status: public
supervisor:
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
title: 'Root system plasticity under nutrient limitation: Investigating hormonal and
  molecular drivers in Arabidopsis thaliana and Coffea  species'
tmp:
  image: /images/cc_by_sa.png
  legal_code_url: https://creativecommons.org/licenses/by-sa/4.0/legalcode
  name: Creative Commons Attribution-ShareAlike 4.0 International Public License (CC
    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
_id: '21363'
abstract:
- lang: eng
  text: The data contains information on coffee differential gene expression as well
    as co-expression and trait correlations in two separate experiments. First, contrasting
    nitrogen supply, second, intra- and interspecific grafting.
article_processing_charge: No
author:
- first_name: Stefan
  full_name: Riegler, Stefan
  id: FF6018E0-D806-11E9-8E43-0B14E6697425
  last_name: Riegler
  orcid: 0000-0003-3413-1343
citation:
  ama: 'Riegler S. Thesis Data for Root System Plasticity under Nutrient Limitation:
    Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea 
    species. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-21363">10.15479/AT-ISTA-21363</a>'
  apa: 'Riegler, S. (2026). Thesis Data for Root System Plasticity under Nutrient
    Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana
    and Coffea  species. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-21363">https://doi.org/10.15479/AT-ISTA-21363</a>'
  chicago: 'Riegler, Stefan. “Thesis Data for Root System Plasticity under Nutrient
    Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana
    and Coffea  Species.” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-21363">https://doi.org/10.15479/AT-ISTA-21363</a>.'
  ieee: 'S. Riegler, “Thesis Data for Root System Plasticity under Nutrient Limitation:
    Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea 
    species.” Institute of Science and Technology Austria, 2026.'
  ista: 'Riegler S. 2026. Thesis Data for Root System Plasticity under Nutrient Limitation:
    Investigating Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea 
    species, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-21363">10.15479/AT-ISTA-21363</a>.'
  mla: 'Riegler, Stefan. <i>Thesis Data for Root System Plasticity under Nutrient
    Limitation: Investigating Hormonal and Molecular Drivers in Arabidopsis Thaliana
    and Coffea  Species</i>. Institute of Science and Technology Austria, 2026, doi:<a
    href="https://doi.org/10.15479/AT-ISTA-21363">10.15479/AT-ISTA-21363</a>.'
  short: S. Riegler, (2026).
contributor:
- contributor_type: supervisor
  first_name: Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
corr_author: '1'
date_created: 2026-02-27T09:18:41Z
date_published: 2026-02-27T00:00:00Z
date_updated: 2026-07-27T14:30:07Z
day: '27'
ddc:
- '575'
department:
- _id: GradSch
- _id: EvBe
doi: 10.15479/AT-ISTA-21363
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  date_created: 2026-02-27T09:11:33Z
  date_updated: 2026-02-27T09:11:33Z
  embargo: 2027-02-27
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  file_name: SupplementaryTables.xlsx
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  date_created: 2026-02-27T09:13:11Z
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has_accepted_license: '1'
month: '02'
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
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status: public
title: 'Thesis Data for Root System Plasticity under Nutrient Limitation: Investigating
  Hormonal and Molecular Drivers in Arabidopsis thaliana and Coffea  species'
tmp:
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    BY-SA 4.0)
  short: CC BY-SA (4.0)
type: research_data
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...
---
OA_type: closed access
_id: '21164'
abstract:
- lang: eng
  text: 'Global emission inventories often fail to capture the complexities of vehicular
    pollution in regions with unique fuel mixes, such as Brazil’s extensive biofuel
    use, leading to significant uncertainties in atmospheric modeling. This study
    presents a century-long (1960–2100) bottom-up vehicular emission inventory for
    Brazil, leveraging locally derived emission factors. Our estimates reveal substantial
    discrepancies in magnitude, timing, and speciation of non-CO2 pollutants (CO,
    NMHC, PM2.5) compared to leading global inventories (EDGAR, CEDS, CAMS), highlighting
    critical inaccuracies in widely used data sets. More critically, future projections
    under Shared Socioeconomic Pathways (SSPs) uncover a novel positive feedback mechanism:
    rising temperatures significantly enhance vehicular evaporative nonmethane hydrocarbon
    (NMHC) emissions. This temperature-dependent increase and subsequent NMHC oxidation
    to CO2 suggest an overlooked pathway that could amplify climate warming and air
    pollution globally, particularly after a breakpoint around 2050 (p < 0.05). While
    historical emissions peaked in the 1990s–2000s, nonexhaust PM becomes increasingly
    important. Air quality simulations using our inventory in the MUSICA model show
    good regional PM2.5 agreement but highlight challenges in resolving local primary
    pollutant peaks. This comprehensive inventory provides crucial data for Brazil
    and uncovers globally relevant climate–chemistry interactions, urging a re-evaluation
    of regional specificities in global emission assessments.'
acknowledgement: Part of this material is based upon work supported by the NSF National
  Center for Atmospheric Research, which is a major facility sponsored by the National
  Science Foundation under Cooperative Agreement No. 1852977. Casallas was supported
  by the European Union’s Horizon 2020 research and innovation program under the Marie
  Skłodowska-Curie grant agreement No. 101034413. E. D. Freitas thanks the support
  provided by the National Council for Scientific and Technological Development (CNPq,
  Process number 313210/2022–5). Silva gratefully acknowledges the financial support
  from the National Council for Scientific and Technological Development (CNPq), process
  number 140512/2021–7. P. Lichtig was supported by base funding from the National
  Commission for Atomic Energy (CNEA, Arg.) and by NSF NCAR. R.Y. Ynoue thanks the
  support provided by the National Council for Scientific and Technological Development
  (CNPq, Process number 406728/2022–4). M. A. Franco thanks the support provided by
  the National Council for Scientific and Technological Development (CNPq, Process
  number 407752/2023–4). G. M. Pereira thanks the support by the Fundação de Amparo
  à Pesquisa do Estado de São Paulo (FAPESP; Process numbers 2018/07848–9, 2016/18438–0,
  and 2019/01316–80) and Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  (CAPES; Process number 88887.103225/2025–00). M.F. Andrade thanks the support by
  FAPESP (Process number 2016/18438–0) and CNPQ (Klimapolis INCT).
article_number: 5c08400
article_processing_charge: No
article_type: original
author:
- first_name: Sergio
  full_name: Ibarra-Espinosa, Sergio
  last_name: Ibarra-Espinosa
- first_name: Edmilson
  full_name: Dias de Freitas, Edmilson
  last_name: Dias de Freitas
- first_name: Benjamin
  full_name: Gaubert, Benjamin
  last_name: Gaubert
- first_name: Pablo
  full_name: Lichtig, Pablo
  last_name: Lichtig
- first_name: Karl
  full_name: Ropkins, Karl
  last_name: Ropkins
- first_name: Iara
  full_name: da Silva, Iara
  last_name: da Silva
- first_name: Guilherme
  full_name: Martins Pereira, Guilherme
  last_name: Martins Pereira
- first_name: Daniel
  full_name: Schuch, Daniel
  last_name: Schuch
- first_name: Janaina
  full_name: Nascimento, Janaina
  last_name: Nascimento
- first_name: Leonardo
  full_name: Hoinaski, Leonardo
  last_name: Hoinaski
- first_name: Leila Droprinchinski
  full_name: Martins, Leila Droprinchinski
  last_name: Martins
- first_name: Mario
  full_name: Gavidia-Calderón, Mario
  last_name: Gavidia-Calderón
- first_name: Angel
  full_name: Vara-Vela, Angel
  last_name: Vara-Vela
- first_name: Taciana
  full_name: Toledo de Almeida Albuquerque, Taciana
  last_name: Toledo de Almeida Albuquerque
- first_name: Rita Yuri
  full_name: Ynoue, Rita Yuri
  last_name: Ynoue
- first_name: Sebastian
  full_name: Diez, Sebastian
  last_name: Diez
- first_name: Zamir
  full_name: Mera, Zamir
  last_name: Mera
- first_name: Alejandro
  full_name: Casallas Garcia, Alejandro
  id: 92081129-2d75-11ef-a48d-b04dd7a2385a
  last_name: Casallas Garcia
  orcid: 0000-0002-1988-5035
- first_name: Fidel
  full_name: Vallejo, Fidel
  last_name: Vallejo
- first_name: Valeria
  full_name: Diaz, Valeria
  last_name: Diaz
- first_name: Rizzieri
  full_name: Pedruzzi, Rizzieri
  last_name: Pedruzzi
- first_name: Rosana
  full_name: Abrutzky, Rosana
  last_name: Abrutzky
- first_name: Marco A.
  full_name: Franco, Marco A.
  last_name: Franco
- first_name: Nicolas
  full_name: Huneeus, Nicolas
  last_name: Huneeus
- first_name: Hector
  full_name: Jorquera, Hector
  last_name: Jorquera
- first_name: Luis Carlos
  full_name: Belalcázar-Cerón, Luis Carlos
  last_name: Belalcázar-Cerón
- first_name: Néstor Y.
  full_name: Rojas, Néstor Y.
  last_name: Rojas
- first_name: Maria
  full_name: de Fatima Andrade, Maria
  last_name: de Fatima Andrade
- first_name: Louisa
  full_name: Emmons, Louisa
  last_name: Emmons
- first_name: Guy
  full_name: Brasseur, Guy
  last_name: Brasseur
citation:
  ama: 'Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, et al. A century of vehicular
    emissions in Brazil: Unveiling the impacts of unique fuel mix on air quality.
    <i>Environmental Science &#38;amp; Technology</i>. 2026;60(6). doi:<a href="https://doi.org/10.1021/acs.est.5c08400">10.1021/acs.est.5c08400</a>'
  apa: 'Ibarra-Espinosa, S., Dias de Freitas, E., Gaubert, B., Lichtig, P., Ropkins,
    K., da Silva, I., … Brasseur, G. (2026). A century of vehicular emissions in Brazil:
    Unveiling the impacts of unique fuel mix on air quality. <i>Environmental Science
    &#38;amp; Technology</i>. American Chemical Society. <a href="https://doi.org/10.1021/acs.est.5c08400">https://doi.org/10.1021/acs.est.5c08400</a>'
  chicago: 'Ibarra-Espinosa, Sergio, Edmilson Dias de Freitas, Benjamin Gaubert, Pablo
    Lichtig, Karl Ropkins, Iara da Silva, Guilherme Martins Pereira, et al. “A Century
    of Vehicular Emissions in Brazil: Unveiling the Impacts of Unique Fuel Mix on
    Air Quality.” <i>Environmental Science &#38;amp; Technology</i>. American Chemical
    Society, 2026. <a href="https://doi.org/10.1021/acs.est.5c08400">https://doi.org/10.1021/acs.est.5c08400</a>.'
  ieee: 'S. Ibarra-Espinosa <i>et al.</i>, “A century of vehicular emissions in Brazil:
    Unveiling the impacts of unique fuel mix on air quality,” <i>Environmental Science
    &#38;amp; Technology</i>, vol. 60, no. 6. American Chemical Society, 2026.'
  ista: 'Ibarra-Espinosa S, Dias de Freitas E, Gaubert B, Lichtig P, Ropkins K, da
    Silva I, Martins Pereira G, Schuch D, Nascimento J, Hoinaski L, Martins LD, Gavidia-Calderón
    M, Vara-Vela A, Toledo de Almeida Albuquerque T, Ynoue RY, Diez S, Mera Z, Casallas
    Garcia A, Vallejo F, Diaz V, Pedruzzi R, Abrutzky R, Franco MA, Huneeus N, Jorquera
    H, Belalcázar-Cerón LC, Rojas NY, de Fatima Andrade M, Emmons L, Brasseur G. 2026.
    A century of vehicular emissions in Brazil: Unveiling the impacts of unique fuel
    mix on air quality. Environmental Science &#38;amp; Technology. 60(6), 5c08400.'
  mla: 'Ibarra-Espinosa, Sergio, et al. “A Century of Vehicular Emissions in Brazil:
    Unveiling the Impacts of Unique Fuel Mix on Air Quality.” <i>Environmental Science
    &#38;amp; Technology</i>, vol. 60, no. 6, 5c08400, American Chemical Society,
    2026, doi:<a href="https://doi.org/10.1021/acs.est.5c08400">10.1021/acs.est.5c08400</a>.'
  short: S. Ibarra-Espinosa, E. Dias de Freitas, B. Gaubert, P. Lichtig, K. Ropkins,
    I. da Silva, G. Martins Pereira, D. Schuch, J. Nascimento, L. Hoinaski, L.D. Martins,
    M. Gavidia-Calderón, A. Vara-Vela, T. Toledo de Almeida Albuquerque, R.Y. Ynoue,
    S. Diez, Z. Mera, A. Casallas Garcia, F. Vallejo, V. Diaz, R. Pedruzzi, R. Abrutzky,
    M.A. Franco, N. Huneeus, H. Jorquera, L.C. Belalcázar-Cerón, N.Y. Rojas, M. de
    Fatima Andrade, L. Emmons, G. Brasseur, Environmental Science &#38;amp; Technology
    60 (2026).
das_tickbox: '1'
dataavailabilitystatement: Scripts available here https://github.com/ibarraespinosa/musica_vein
  and here https://github.com/atmoschem/vein.
date_created: 2026-02-09T06:54:10Z
date_published: 2026-02-17T00:00:00Z
date_updated: 2026-07-28T07:03:54Z
day: '17'
ddc:
- '550'
department:
- _id: CaMu
doi: 10.1021/acs.est.5c08400
ec_funded: 1
external_id:
  pmid:
  - '41636708'
has_accepted_license: '1'
intvolume: '        60'
issue: '6'
language:
- iso: eng
month: '02'
oa_version: None
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Environmental Science &amp; Technology
publication_identifier:
  eissn:
  - 1520-5851
  issn:
  - 0013-936X
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: 'A century of vehicular emissions in Brazil: Unveiling the impacts of unique
  fuel mix on air quality'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 60
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20971'
abstract:
- lang: eng
  text: Mountain glaciers are among the natural systems most vulnerable to climate
    change. However, their interactions with the atmosphere are complex and not fully
    understood. These interactions can trigger rapid adjustments and climate feedbacks
    that either amplify or attenuate atmospheric signals, influencing both glacier
    response and large-scale atmospheric circulation. Observing this functional coupling
    in nature is challenging because the key processes occur over a wide range of
    spatial and temporal scales. However, recent advances in observational techniques
    and modeling have provided new insights into these interactions. In this review,
    we summarize the current state of knowledge on glacier-atmosphere interactions
    in high-mountain regions at different scales, and highlight recent advances in
    observational and numerical modeling. We also highlight important knowledge gaps
    and outline future research directions to improve the prediction of glacier change
    in a warming world.
acknowledgement: This work is the result of collaboration and discussions within HEFEX
  II, and we are grateful to all colleagues who have contributed to and enriched these
  discussions in various ways. T. Sauter acknowledges funding from the German Research
  Foundation (DFG) (Grant 543257843). This research was funded in part by the Austrian
  Science Fund (FWF) (Grant https://doi.org/10.55776/P36624 and https://doi.org/10.55776/P36306)
  for which E. Collier and R. Prinz are grateful. A. R. Groos, T. E. Shaw, R. Mott
  and M. Haugeneder acknowledge Transnational Access from the European Union's H2020
  project INTERACT III (Grant 871120) for participation in the HEFEX II campaign and
  working group. I. Stiperski (Grant Agreement No. 101001691) and A. R. Groos (Grant
  Agreement No. 948290) acknowledge funding from the European Research Council (ERC)
  under the European Union's Horizon 2020 research and innovation program. R. Mott
  acknowledges funding from the Swiss National Science Foundation (SNSF) (Grant 200021_219918).
  B. Goger is supported by EXCLAIM, a project funded by ETH Zurich. J.E. Sicart acknowledges
  LabEx OSUG@2020 (Investissements d'avenir - ANR10 LABX56) for participation in the
  HEFEX II campaign and working group. T. E. Shaw acknowledges funding from the EU
  Horizon 2020 Marie Skłodowska-Curie Grant 101026058 and 101034413. K. F. Haualand
  and T. Sauter are supported by the JOSTICE project funded by the Research Council
  of Norway (RCN Grant 302458).
article_number: e2024RG000869
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: T.
  full_name: Sauter, T.
  last_name: Sauter
- first_name: B. W.
  full_name: Brock, B. W.
  last_name: Brock
- first_name: E.
  full_name: Collier, E.
  last_name: Collier
- first_name: B.
  full_name: Goger, B.
  last_name: Goger
- first_name: A. R.
  full_name: Groos, A. R.
  last_name: Groos
- first_name: K. F.
  full_name: Haualand, K. F.
  last_name: Haualand
- first_name: R.
  full_name: Mott, R.
  last_name: Mott
- first_name: L.
  full_name: Nicholson, L.
  last_name: Nicholson
- first_name: R.
  full_name: Prinz, R.
  last_name: Prinz
- first_name: Thomas
  full_name: Shaw, Thomas
  id: 3caa3f91-1f03-11ee-96ce-e0e553054d6e
  last_name: Shaw
  orcid: 0000-0001-7640-6152
- first_name: I.
  full_name: Stiperski, I.
  last_name: Stiperski
- first_name: A.
  full_name: Georgi, A.
  last_name: Georgi
- first_name: M.
  full_name: Haugeneder, M.
  last_name: Haugeneder
- first_name: A.
  full_name: Mandal, A.
  last_name: Mandal
- first_name: D.
  full_name: Reynolds, D.
  last_name: Reynolds
- first_name: M.
  full_name: Saigger, M.
  last_name: Saigger
- first_name: J. E.
  full_name: Sicart, J. E.
  last_name: Sicart
- first_name: A.
  full_name: Voordendag, A.
  last_name: Voordendag
citation:
  ama: Sauter T, Brock BW, Collier E, et al. Glacier-atmosphere interactions and feedbacks
    in high-mountain regions - A review. <i>Reviews of Geophysics</i>. 2026;64(1).
    doi:<a href="https://doi.org/10.1029/2024RG000869">10.1029/2024RG000869</a>
  apa: Sauter, T., Brock, B. W., Collier, E., Goger, B., Groos, A. R., Haualand, K.
    F., … Voordendag, A. (2026). Glacier-atmosphere interactions and feedbacks in
    high-mountain regions - A review. <i>Reviews of Geophysics</i>. Wiley. <a href="https://doi.org/10.1029/2024RG000869">https://doi.org/10.1029/2024RG000869</a>
  chicago: Sauter, T., B. W. Brock, E. Collier, B. Goger, A. R. Groos, K. F. Haualand,
    R. Mott, et al. “Glacier-Atmosphere Interactions and Feedbacks in High-Mountain
    Regions - A Review.” <i>Reviews of Geophysics</i>. Wiley, 2026. <a href="https://doi.org/10.1029/2024RG000869">https://doi.org/10.1029/2024RG000869</a>.
  ieee: T. Sauter <i>et al.</i>, “Glacier-atmosphere interactions and feedbacks in
    high-mountain regions - A review,” <i>Reviews of Geophysics</i>, vol. 64, no.
    1. Wiley, 2026.
  ista: Sauter T, Brock BW, Collier E, Goger B, Groos AR, Haualand KF, Mott R, Nicholson
    L, Prinz R, Shaw T, Stiperski I, Georgi A, Haugeneder M, Mandal A, Reynolds D,
    Saigger M, Sicart JE, Voordendag A. 2026. Glacier-atmosphere interactions and
    feedbacks in high-mountain regions - A review. Reviews of Geophysics. 64(1), e2024RG000869.
  mla: Sauter, T., et al. “Glacier-Atmosphere Interactions and Feedbacks in High-Mountain
    Regions - A Review.” <i>Reviews of Geophysics</i>, vol. 64, no. 1, e2024RG000869,
    Wiley, 2026, doi:<a href="https://doi.org/10.1029/2024RG000869">10.1029/2024RG000869</a>.
  short: T. Sauter, B.W. Brock, E. Collier, B. Goger, A.R. Groos, K.F. Haualand, R.
    Mott, L. Nicholson, R. Prinz, T. Shaw, I. Stiperski, A. Georgi, M. Haugeneder,
    A. Mandal, D. Reynolds, M. Saigger, J.E. Sicart, A. Voordendag, Reviews of Geophysics
    64 (2026).
das_tickbox: '1'
dataavailabilitystatement: Data were not used, nor created for this research. Software
  (other than for typesetting) was not used for this research.
date_created: 2026-01-11T23:01:33Z
date_published: 2026-03-01T00:00:00Z
date_updated: 2026-07-28T06:49:58Z
day: '01'
ddc:
- '550'
department:
- _id: FrPe
doi: 10.1029/2024RG000869
ec_funded: 1
file:
- access_level: open_access
  checksum: 9d46167619be91210c45ee9e1f187395
  content_type: application/pdf
  creator: dernst
  date_created: 2026-07-28T06:48:08Z
  date_updated: 2026-07-28T06:48:08Z
  file_id: '22594'
  file_name: 2026_ReviewsGeophysics_Sauter.pdf
  file_size: 3012737
  relation: main_file
  success: 1
file_date_updated: 2026-07-28T06:48:08Z
has_accepted_license: '1'
intvolume: '        64'
issue: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
  call_identifier: H2020
  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
publication: Reviews of Geophysics
publication_identifier:
  eissn:
  - 1944-9208
  issn:
  - 8755-1209
publication_status: published
publisher: Wiley
quality_controlled: '1'
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Glacier-atmosphere interactions and feedbacks in high-mountain regions - A
  review
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 64
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '20935'
abstract:
- lang: eng
  text: In situ cryo-electron tomography (cryo-ET) has emerged as the method of choice
    to investigate the structures of biomolecules in their native context. However,
    challenges remain for the efficient production and sharing of large-scale cryo-ET
    datasets. Here, we combined cryogenic plasma-based focused ion beam (cryo-PFIB)
    milling with recent advances in cryo-ET acquisition and processing to generate
    a dataset of 1,829 annotated tomograms of the green alga Chlamydomonas reinhardtii,
    which we provide as a community resource to drive method development and inspire
    biological discovery. To assay data quality, we performed subtomogram averaging
    of both soluble and membrane-bound complexes ranging in size from >3 MDa to ∼200
    kDa, including 80S ribosomes, Rubisco, nucleosomes, microtubules, clathrin, photosystem
    II, and mitochondrial ATP synthase. The majority of these density maps reached
    sub-nanometer resolution, demonstrating the potential of this C. reinhardtii dataset
    as well as the promise of modern cryo-ET workflows and open data sharing to empower
    visual proteomics.
acknowledgement: Calculations were performed at the Max Planck Institute of Biochemistry
  and the Raven Supercomputer of the Max Planck Computing and Data Facility (MPCDF)
  in Garching, Germany; at the sciCORE (http://scicore.unibas.ch/) scientific computing
  center at the University of Basel, Switzerland; and at Thermo Fisher Scientific,
  in Eindhoven, the Netherlands. This work was supported by Thermo Fisher Scientific.
  All lamella preparations and tilt-series collections used in this work were conducted
  at Thermo Fisher R&D facilities in Brno and Eindhoven, utilizing Arctis and Krios
  microscopes. This work was also supported by the ERC consolidator grant “cryOcean”
  (fulfilled by the Swiss State Secretariat for Education, Research and Innovation,
  M822.00045) as well as a Swiss Nanoscience Institute PhD school grant to B.D.E.
  and P.V.d.S., an EMBO long-term postdoctoral fellowship (ALTF-383-2022) to G.T.,
  an SNSF Postdoctoral Fellowship (project 210561) to F.W., a Boehringer Ingelheim
  Fonds fellowship to L.L., and by the Max Planck Society to J.A.G.B. and J.M.P.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Ron
  full_name: Kelley, Ron
  last_name: Kelley
- first_name: Sagar
  full_name: Khavnekar, Sagar
  last_name: Khavnekar
- first_name: Ricardo D.
  full_name: Righetto, Ricardo D.
  last_name: Righetto
- first_name: Jessica
  full_name: Heebner, Jessica
  last_name: Heebner
- first_name: Martin
  full_name: Obr, Martin
  id: 4741CA5A-F248-11E8-B48F-1D18A9856A87
  last_name: Obr
  orcid: 0000-0003-1756-6564
- first_name: Xianjun
  full_name: Zhang, Xianjun
  last_name: Zhang
- first_name: Saikat
  full_name: Chakraborty, Saikat
  last_name: Chakraborty
- first_name: Grigory
  full_name: Tagiltsev, Grigory
  last_name: Tagiltsev
- first_name: Alicia
  full_name: Michael, Alicia
  id: 6437c950-2a03-11ee-914d-d6476dd7b75c
  last_name: Michael
  orcid: 0000-0002-6080-839X
- first_name: Sofie
  full_name: Van Dorst, Sofie
  last_name: Van Dorst
- first_name: Florent
  full_name: Waltz, Florent
  last_name: Waltz
- first_name: Caitlyn L.
  full_name: Mccafferty, Caitlyn L.
  last_name: Mccafferty
- first_name: Lorenz
  full_name: Lamm, Lorenz
  last_name: Lamm
- first_name: Simon
  full_name: Zufferey, Simon
  last_name: Zufferey
- first_name: Philippe
  full_name: Van Der Stappen, Philippe
  last_name: Van Der Stappen
- first_name: Hugo
  full_name: Van Den Hoek, Hugo
  last_name: Van Den Hoek
- first_name: Wojciech
  full_name: Wietrzynski, Wojciech
  last_name: Wietrzynski
- first_name: Pavol
  full_name: Harar, Pavol
  id: e03d953a-6e8c-11ef-99e4-f0717d385cd5
  last_name: Harar
  orcid: 0000-0001-5206-1794
- first_name: William
  full_name: Wan, William
  last_name: Wan
- first_name: John A.G.
  full_name: Briggs, John A.G.
  last_name: Briggs
- first_name: Jürgen M.
  full_name: Plitzko, Jürgen M.
  last_name: Plitzko
- first_name: Benjamin D.
  full_name: Engel, Benjamin D.
  last_name: Engel
- first_name: Abhay
  full_name: Kotecha, Abhay
  last_name: Kotecha
citation:
  ama: Kelley R, Khavnekar S, Righetto RD, et al. Toward community-driven visual proteomics
    with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. <i>Molecular
    Cell</i>. 2026;86(1):213-230.e7. doi:<a href="https://doi.org/10.1016/j.molcel.2025.11.029">10.1016/j.molcel.2025.11.029</a>
  apa: Kelley, R., Khavnekar, S., Righetto, R. D., Heebner, J., Obr, M., Zhang, X.,
    … Kotecha, A. (2026). Toward community-driven visual proteomics with large-scale
    cryo-electron tomography of Chlamydomonas reinhardtii. <i>Molecular Cell</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.molcel.2025.11.029">https://doi.org/10.1016/j.molcel.2025.11.029</a>
  chicago: Kelley, Ron, Sagar Khavnekar, Ricardo D. Righetto, Jessica Heebner, Martin
    Obr, Xianjun Zhang, Saikat Chakraborty, et al. “Toward Community-Driven Visual
    Proteomics with Large-Scale Cryo-Electron Tomography of Chlamydomonas Reinhardtii.”
    <i>Molecular Cell</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.molcel.2025.11.029">https://doi.org/10.1016/j.molcel.2025.11.029</a>.
  ieee: R. Kelley <i>et al.</i>, “Toward community-driven visual proteomics with large-scale
    cryo-electron tomography of Chlamydomonas reinhardtii,” <i>Molecular Cell</i>,
    vol. 86, no. 1. Elsevier, p. 213–230.e7, 2026.
  ista: Kelley R, Khavnekar S, Righetto RD, Heebner J, Obr M, Zhang X, Chakraborty
    S, Tagiltsev G, Michael AK, Van Dorst S, Waltz F, Mccafferty CL, Lamm L, Zufferey
    S, Van Der Stappen P, Van Den Hoek H, Wietrzynski W, Harar P, Wan W, Briggs JAG,
    Plitzko JM, Engel BD, Kotecha A. 2026. Toward community-driven visual proteomics
    with large-scale cryo-electron tomography of Chlamydomonas reinhardtii. Molecular
    Cell. 86(1), 213–230.e7.
  mla: Kelley, Ron, et al. “Toward Community-Driven Visual Proteomics with Large-Scale
    Cryo-Electron Tomography of Chlamydomonas Reinhardtii.” <i>Molecular Cell</i>,
    vol. 86, no. 1, Elsevier, 2026, p. 213–230.e7, doi:<a href="https://doi.org/10.1016/j.molcel.2025.11.029">10.1016/j.molcel.2025.11.029</a>.
  short: R. Kelley, S. Khavnekar, R.D. Righetto, J. Heebner, M. Obr, X. Zhang, S.
    Chakraborty, G. Tagiltsev, A.K. Michael, S. Van Dorst, F. Waltz, C.L. Mccafferty,
    L. Lamm, S. Zufferey, P. Van Der Stappen, H. Van Den Hoek, W. Wietrzynski, P.
    Harar, W. Wan, J.A.G. Briggs, J.M. Plitzko, B.D. Engel, A. Kotecha, Molecular
    Cell 86 (2026) 213–230.e7.
das_tickbox: '1'
dataavailabilitystatement: "Raw EM data are available at the EMPIAR under accession
  code EMPIAR: EMPIAR-11830. Annotation and processing information for all 1,829 tomograms
  are provided in spreadsheet format.153 The following subtomogram averages have been
  deposited at the Electron Microscopy Data Bank (EMDB): 80S ribosome (EMDB: EMD-51847),
  nucleosome (EMDB: EMD-19906), PSII (EMDB: EMD-51731), Rubisco (EMDB: EMD-51848),
  microtubule (EMDB: EMD-51804), clathrin (EMDB: EMD-51789), and ATP synthase (EMDB:
  EMD-51802). Segmentations shown in Figures 2 and 3 are deposited on Zenodo (https://doi.org/10.5281/zenodo.15875785).
  Particle positions and orientations used for STA, along with all resources derived
  from this work, are available on GitHub (https://github.com/Chromatin-Structure-Rhythms-Lab/ChlamyAnnotations).
  Reconstructed tomograms and annotations are also available to explore interactively
  at the CZII Cryo-ET Data Portal (DS-10302, https://cryoetdataportal.czscience.com/datasets/10302/).
  Raw data for cryo-PFIB/SEM slice-and-view of a whole C. reinhardtii cell has also
  been deposited (EMPIAR: EMPIAR-11275).\r\n\r\nThis paper does not report original
  code.\r\n\r\nAny additional information required to reanalyze the data reported
  in this paper is available from the lead contact upon request."
date_created: 2026-01-04T23:01:36Z
date_published: 2026-01-08T00:00:00Z
date_updated: 2026-07-28T07:39:23Z
day: '08'
ddc:
- '570'
department:
- _id: AlMi
doi: 10.1016/j.molcel.2025.11.029
file:
- access_level: open_access
  checksum: 96a2f8519124d1a0d9de8d2594bf7147
  content_type: application/pdf
  creator: dernst
  date_created: 2026-07-28T07:38:45Z
  date_updated: 2026-07-28T07:38:45Z
  file_id: '22599'
  file_name: 2026_MolecularCell_Kelley.pdf
  file_size: 26749637
  relation: main_file
  success: 1
file_date_updated: 2026-07-28T07:38:45Z
has_accepted_license: '1'
intvolume: '        86'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: 213-230.e7
publication: Molecular Cell
publication_identifier:
  eissn:
  - 1097-4164
  issn:
  - 1097-2765
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Toward community-driven visual proteomics with large-scale cryo-electron tomography
  of Chlamydomonas reinhardtii
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 86
year: '2026'
...
---
OA_place: repository
OA_type: green
_id: '20858'
abstract:
- lang: eng
  text: Targeted antigen delivery to immune cells, particularly dendritic cells, has
    emerged as a promising strategy to enhance therapeutic efficacy of vaccines, while
    minimizing adverse effects associated with conventional immunization. In this
    study, we use our previously described small glycomimetic molecule that is selectively
    recognized by the Langerhans cell (LC)-specific surface receptor Langerin and
    demonstrate specific delivery of protein antigens to these specialized dendritic
    cells. Our results show that Langerin-mediated antigen delivery significantly
    enhances the immune response in vivo, resulting in increased expansion and activation
    of antigen-specific T cells, compared to immunization with unmodified antigen.
    We demonstrate the feasibility of our LC-targeted platform for immune cell-specific
    immunization with protein antigen and underscore the potential of LCs as an access
    point for next-generation vaccines and immunotherapies.
acknowledgement: This project was generously supported by Seedfinancing (grant no.
  P2282679) of the Austrian Bundesministerium für Digitalisierung und Wirtschaftsstandort
  and the Bundesministerium für Klimaschutz, Umwelt, Energie, Mobilität, Innovation,
  und Technologie, handled by the Austrian Wirtschaftsservice (aws), as well as by
  Life Science Call 2022 (grant no. FO999896442) of the Austrian Research Promotion
  Agency (FFG). We thank Mag. Michael Schunn from the PCF of the Institute of Science
  and Technology Austria for his continuous technical support.
article_processing_charge: No
article_type: original
author:
- first_name: Ramona
  full_name: Rica, Ramona
  last_name: Rica
- first_name: Klara
  full_name: Klein, Klara
  last_name: Klein
- first_name: Litty
  full_name: Johnson, Litty
  last_name: Johnson
- first_name: Gabriele
  full_name: Carta, Gabriele
  last_name: Carta
- first_name: Mirza
  full_name: Sarcevic, Mirza
  last_name: Sarcevic
- first_name: Freyja
  full_name: Langer, Freyja
  id: 3C1BE782-F248-11E8-B48F-1D18A9856A87
  last_name: Langer
- first_name: Christoph
  full_name: Rademacher, Christoph
  last_name: Rademacher
- first_name: Robert
  full_name: Wawrzinek, Robert
  last_name: Wawrzinek
- first_name: Federica
  full_name: Quattrone, Federica
  last_name: Quattrone
- first_name: Florian
  full_name: Sparber, Florian
  last_name: Sparber
biorxivid: 1
citation:
  ama: Rica R, Klein K, Johnson L, et al. Langerhans cell-targeted protein delivery
    enhances antigen-specific cellular immune response. <i>Molecular Therapy</i>.
    2026;34(1):397-406. doi:<a href="https://doi.org/10.1016/j.ymthe.2025.10.008">10.1016/j.ymthe.2025.10.008</a>
  apa: Rica, R., Klein, K., Johnson, L., Carta, G., Sarcevic, M., Langer, F., … Sparber,
    F. (2026). Langerhans cell-targeted protein delivery enhances antigen-specific
    cellular immune response. <i>Molecular Therapy</i>. Elsevier. <a href="https://doi.org/10.1016/j.ymthe.2025.10.008">https://doi.org/10.1016/j.ymthe.2025.10.008</a>
  chicago: Rica, Ramona, Klara Klein, Litty Johnson, Gabriele Carta, Mirza Sarcevic,
    Freyja Langer, Christoph Rademacher, Robert Wawrzinek, Federica Quattrone, and
    Florian Sparber. “Langerhans Cell-Targeted Protein Delivery Enhances Antigen-Specific
    Cellular Immune Response.” <i>Molecular Therapy</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.ymthe.2025.10.008">https://doi.org/10.1016/j.ymthe.2025.10.008</a>.
  ieee: R. Rica <i>et al.</i>, “Langerhans cell-targeted protein delivery enhances
    antigen-specific cellular immune response,” <i>Molecular Therapy</i>, vol. 34,
    no. 1. Elsevier, pp. 397–406, 2026.
  ista: Rica R, Klein K, Johnson L, Carta G, Sarcevic M, Langer F, Rademacher C, Wawrzinek
    R, Quattrone F, Sparber F. 2026. Langerhans cell-targeted protein delivery enhances
    antigen-specific cellular immune response. Molecular Therapy. 34(1), 397–406.
  mla: Rica, Ramona, et al. “Langerhans Cell-Targeted Protein Delivery Enhances Antigen-Specific
    Cellular Immune Response.” <i>Molecular Therapy</i>, vol. 34, no. 1, Elsevier,
    2026, pp. 397–406, doi:<a href="https://doi.org/10.1016/j.ymthe.2025.10.008">10.1016/j.ymthe.2025.10.008</a>.
  short: R. Rica, K. Klein, L. Johnson, G. Carta, M. Sarcevic, F. Langer, C. Rademacher,
    R. Wawrzinek, F. Quattrone, F. Sparber, Molecular Therapy 34 (2026) 397–406.
dataavailabilitystatement: The data that support the findings of this study are available
  on request from the corresponding authors.
date_created: 2025-12-28T23:01:26Z
date_published: 2026-01-07T00:00:00Z
date_updated: 2026-07-28T07:37:08Z
day: '07'
department:
- _id: PreCl
doi: 10.1016/j.ymthe.2025.10.008
external_id:
  biorxivid:
  - 10.1101/2025.05.05.652195
intvolume: '        34'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/2025.05.05.652195
month: '01'
oa: 1
oa_version: Preprint
page: 397-406
publication: Molecular Therapy
publication_identifier:
  eissn:
  - 1525-0024
  issn:
  - 1525-0016
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Langerhans cell-targeted protein delivery enhances antigen-specific cellular
  immune response
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 34
year: '2026'
...
---
OA_type: closed access
_id: '20537'
abstract:
- lang: eng
  text: In this personal account, I describe the work performed in my research group
    on the development of methods that harness heterogeneous photocatalysts for light-mediated
    nickel-catalyzed cross-couplings. This includes catalytic systems using carbon
    nitride materials, dye-sensitized TiO₂, covalent organic frameworks (COFs), and
    conjugated polymers. The rationale behind the selection of materials and how their
    use led to the identification of catalyst deactivation, structure–activity relationships,
    and future opportunities is discussed.
article_processing_charge: No
article_type: original
author:
- first_name: Bartholomäus
  full_name: Pieber, Bartholomäus
  id: 93e5e5b2-0da6-11ed-8a41-af589a024726
  last_name: Pieber
  orcid: 0000-0001-8689-388X
citation:
  ama: Pieber B. Photochemical cross-couplings using semiconducting materials. <i>Synlett</i>.
    2026;37(1):43-54. doi:<a href="https://doi.org/10.1055/a-2690-9269">10.1055/a-2690-9269</a>
  apa: Pieber, B. (2026). Photochemical cross-couplings using semiconducting materials.
    <i>Synlett</i>. Georg Thieme Verlag. <a href="https://doi.org/10.1055/a-2690-9269">https://doi.org/10.1055/a-2690-9269</a>
  chicago: Pieber, Bartholomäus. “Photochemical Cross-Couplings Using Semiconducting
    Materials.” <i>Synlett</i>. Georg Thieme Verlag, 2026. <a href="https://doi.org/10.1055/a-2690-9269">https://doi.org/10.1055/a-2690-9269</a>.
  ieee: B. Pieber, “Photochemical cross-couplings using semiconducting materials,”
    <i>Synlett</i>, vol. 37, no. 1. Georg Thieme Verlag, pp. 43–54, 2026.
  ista: Pieber B. 2026. Photochemical cross-couplings using semiconducting materials.
    Synlett. 37(1), 43–54.
  mla: Pieber, Bartholomäus. “Photochemical Cross-Couplings Using Semiconducting Materials.”
    <i>Synlett</i>, vol. 37, no. 1, Georg Thieme Verlag, 2026, pp. 43–54, doi:<a href="https://doi.org/10.1055/a-2690-9269">10.1055/a-2690-9269</a>.
  short: B. Pieber, Synlett 37 (2026) 43–54.
corr_author: '1'
das_tickbox: '1'
date_created: 2025-10-26T23:01:35Z
date_published: 2026-01-01T00:00:00Z
date_updated: 2026-07-28T07:42:47Z
day: '01'
department:
- _id: BaPi
doi: 10.1055/a-2690-9269
external_id:
  isi:
  - '001582268500001'
intvolume: '        37'
isi: 1
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 43-54
publication: Synlett
publication_identifier:
  eissn:
  - 1437-2096
  issn:
  - 0936-5214
publication_status: published
publisher: Georg Thieme Verlag
quality_controlled: '1'
scopus_import: '1'
status: public
title: Photochemical cross-couplings using semiconducting materials
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2026'
...
---
OA_place: publisher
_id: '22258'
abstract:
- lang: eng
  text: "Uncovering the genetic architecture of complex traits and pinpointing causal
    molecular drivers require the ability to distinguish true signals from noise within
    massive, high-dimensional omics datasets. To extract meaningful biological insights
    from these datasets, such as identifying causal genetic variants and proteins,
    scalable and accurate inference methods are essential. To this end, this thesis
    develops novel Bayesian inference frameworks based on Vector Approximate Message
    Passing and demonstrates their effectiveness in the modeling of disease onset
    times and quantitative physical and clinical measures.\r\n\r\nFirst, we introduce
    gVAMP, a Bayesian framework tailored for Genome-Wide Association Studies that
    enables the joint modeling of quantitative complex traits across millions of genetic
    variants. gVAMP demonstrates superior accuracy in variable selection and out-of-sample
    polygenic risk prediction compared to state-of-the-art approaches. We model human
    height using 17 million whole-genome sequence variants from the UK Biobank, incorporating
    a vast number of rare variants and revealing novel associations. gVAMP achieves
    a prediction accuracy of approximately 46% for human height, representing the
    highest reported performance for this trait to date. \r\n\r\nSecond, we present
    vampW, a Bayesian framework for survival analysis applied to proteomic data. By
    effectively handling right-censoring and complex protein dependencies within the
    UK Biobank Pharma Proteomics Project dataset, vampW identifies 219 protein associations
    across 24 disease outcomes, the majority of which are not among the top marginal
    discoveries. We further adjust protein levels for exponential age effects, yielding
    1,308 associations and highlighting the sensitivity of the analysis to the chosen
    age-correction methodology. Finally, vampW improves upon the variable selection
    capabilities of the commonly used (penalized) variants of the Cox proportional
    hazards model and delivers state-of-the-art out-of-sample prediction of disease
    onset times.\r\n\r\nCollectively, these methods provide powerful tools for dissecting
    the genetic architecture of complex traits and the proteomic drivers of disease
    onset. Furthermore, by delivering accurate polygenic risk scores and precise predictions
    of onset times, this work advances the capabilities of personalized medicine and
    clinical risk stratification."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "This work was supported in part by the Swiss National Science Foundation
  through the\r\nEccellenza Grant \"Improving estimation and prediction of common
  complex disease risk\"\r\n(grant number PCEGP3_181181); the European Research Council
  through the grant\r\n\"Inference in High Dimensions: Light-speed Algorithms and
  Information Limits\" (grant\r\nnumber 101161364); and the Fondation Jean-Jacques
  et Felicia Lopez-Loreta through the\r\nPrix Lopez-Loretta 2019.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Al
  full_name: Depope, Al
  id: 0b77531d-dbcd-11ea-9d1d-a8eee0bf3830
  last_name: Depope
citation:
  ama: 'Depope A. From sparse selection to risk prediction: Approximate message passing
    for proteomic survival models and large-scale genomics. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22258">10.15479/AT-ISTA-22258</a>'
  apa: 'Depope, A. (2026). <i>From sparse selection to risk prediction: Approximate
    message passing for proteomic survival models and large-scale genomics</i>. Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22258">https://doi.org/10.15479/AT-ISTA-22258</a>'
  chicago: 'Depope, Al. “From Sparse Selection to Risk Prediction: Approximate Message
    Passing for Proteomic Survival Models and Large-Scale Genomics.” Institute of
    Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22258">https://doi.org/10.15479/AT-ISTA-22258</a>.'
  ieee: 'A. Depope, “From sparse selection to risk prediction: Approximate message
    passing for proteomic survival models and large-scale genomics,” Institute of
    Science and Technology Austria, 2026.'
  ista: 'Depope A. 2026. From sparse selection to risk prediction: Approximate message
    passing for proteomic survival models and large-scale genomics. Institute of Science
    and Technology Austria.'
  mla: 'Depope, Al. <i>From Sparse Selection to Risk Prediction: Approximate Message
    Passing for Proteomic Survival Models and Large-Scale Genomics</i>. Institute
    of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22258">10.15479/AT-ISTA-22258</a>.'
  short: 'A. Depope, From Sparse Selection to Risk Prediction: Approximate Message
    Passing for Proteomic Survival Models and Large-Scale Genomics, Institute of Science
    and Technology Austria, 2026.'
corr_author: '1'
das_tickbox: '1'
date_created: 2026-07-10T13:27:20Z
date_published: 2026-07-11T00:00:00Z
date_updated: 2026-07-28T07:08:15Z
day: '11'
ddc:
- '576'
- '610'
- '006'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaRo
- _id: MaMo
doi: 10.15479/AT-ISTA-22258
doi_confirm: '1'
file:
- access_level: open_access
  checksum: 9ab386790515628d957a194f30a7ccb4
  content_type: application/pdf
  creator: adepope
  date_created: 2026-07-13T14:52:19Z
  date_updated: 2026-07-13T14:52:19Z
  file_id: '22316'
  file_name: 2026_Depope_Al_Thesis.pdf
  file_size: 25109878
  relation: main_file
- access_level: closed
  checksum: 8ed8fb63f76a695d5b6fec35343f4b90
  content_type: application/zip
  creator: adepope
  date_created: 2026-07-13T14:56:41Z
  date_updated: 2026-07-13T14:56:41Z
  file_id: '22317'
  file_name: 2026_Depope_Al_Thesis.zip
  file_size: 1203199939
  relation: source_file
file_date_updated: 2026-07-13T14:56:41Z
has_accepted_license: '1'
keyword:
- Approximate Message Passing
- GWAS
- Genomics
- Proteomics
- Survival modeling
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '169'
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
- _id: 911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf
  grant_number: '101161364'
  name: 'Inference in High Dimensions: Light-speed Algorithms and Information Limits'
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
  grant_number: PCEGP3_181181
  name: Improving estimation and prediction of common complex disease risk
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '21488'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
title: 'From sparse selection to risk prediction: Approximate message passing for
  proteomic survival models and large-scale genomics'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '21488'
abstract:
- lang: eng
  text: Human height is a model for the genetic analysis of complex traits, and recent
    studies suggest the presence of thousands of common genetic variant associations
    and hundreds of low-frequency/rare variants. Here, we develop a new algorithmic
    paradigm based on approximate message passing (genomic vector approximate message
    passing [gVAMP]) for identifying DNA sequence variants associated with complex
    traits and common diseases in large-scale whole-genome sequencing (WGS) data.
    We show that gVAMP accurately localizes associations to variants with the correct
    frequency and position in the DNA, outperforming existing fine-mapping methods
    in selecting the appropriate genetic variants within WGS data. We then apply gVAMP
    to jointly model the relationship of tens of millions of WGS variants with human
    height in hundreds of thousands of UK Biobank individuals. We identify 59 rare
    variants and gene burden scores alongside many hundreds of DNA regions containing
    common variant associations and show that understanding the genetic basis of complex
    traits will require the joint analysis of hundreds of millions of variables measured
    on millions of people. The polygenic risk scores obtained from gVAMP have high
    accuracy (including a prediction accuracy of ∼46% for human height) and outperform
    current methods for downstream tasks such as mixed linear model association testing
    across 13 UK Biobank traits. In conclusion, gVAMP offers a scalable foundation
    for a wider range of analyses in WGS data.
acknowledgement: We thank Malgorzata Borczyk for creating the gene burden scores.
  We thank Robin Beaumont, Amedeo Roberto Esposito, Gareth Hawkes, Philip Schniter,
  Matthew Stephens, Pragya Sur, Peter Visscher, Michael Weedon, and Harry Wright for
  providing valuable suggestions and comments on earlier versions of the work. This
  project was funded by a Lopez-Loreta Prize to M.M., an SNSF Eccellenza Grant to
  M.R.R. (PCEGP3-181181), an ERC Starting Grant to M.M. (INF2, project number 101161364),
  and core funding from ISTA. High-performance computing was supported by the Scientific
  Service Units (SSU) of ISTA through resources provided by Scientific Computing (SciComp).
  We would like to acknowledge the participants and investigators of the UK Biobank
  study. We gratefully acknowledge the All of Us participants for their contributions,
  without whom this research would not have been possible. We also thank the National
  Institutes of Health All of Us Research Program for making available the participant
  data (and/or samples and/or cohort) examined in this study.
article_number: '101162'
article_processing_charge: Yes
article_type: original
author:
- first_name: Al
  full_name: Depope, Al
  id: 0b77531d-dbcd-11ea-9d1d-a8eee0bf3830
  last_name: Depope
- first_name: Jakub
  full_name: Bajzik, Jakub
  id: b995e25b-8c4b-11ed-a6d8-f71b7bcd6122
  last_name: Bajzik
- first_name: Marco
  full_name: Mondelli, Marco
  id: 27EB676C-8706-11E9-9510-7717E6697425
  last_name: Mondelli
  orcid: 0000-0002-3242-7020
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
citation:
  ama: Depope A, Bajzik J, Mondelli M, Robinson MR. Joint modeling of whole-genome
    sequencing data for human height via approximate message passing. <i>Cell Genomics</i>.
    2026;6(5). doi:<a href="https://doi.org/10.1016/j.xgen.2026.101162">10.1016/j.xgen.2026.101162</a>
  apa: Depope, A., Bajzik, J., Mondelli, M., &#38; Robinson, M. R. (2026). Joint modeling
    of whole-genome sequencing data for human height via approximate message passing.
    <i>Cell Genomics</i>. Elsevier. <a href="https://doi.org/10.1016/j.xgen.2026.101162">https://doi.org/10.1016/j.xgen.2026.101162</a>
  chicago: Depope, Al, Jakub Bajzik, Marco Mondelli, and Matthew Richard Robinson.
    “Joint Modeling of Whole-Genome Sequencing Data for Human Height via Approximate
    Message Passing.” <i>Cell Genomics</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.xgen.2026.101162">https://doi.org/10.1016/j.xgen.2026.101162</a>.
  ieee: A. Depope, J. Bajzik, M. Mondelli, and M. R. Robinson, “Joint modeling of
    whole-genome sequencing data for human height via approximate message passing,”
    <i>Cell Genomics</i>, vol. 6, no. 5. Elsevier, 2026.
  ista: Depope A, Bajzik J, Mondelli M, Robinson MR. 2026. Joint modeling of whole-genome
    sequencing data for human height via approximate message passing. Cell Genomics.
    6(5), 101162.
  mla: Depope, Al, et al. “Joint Modeling of Whole-Genome Sequencing Data for Human
    Height via Approximate Message Passing.” <i>Cell Genomics</i>, vol. 6, no. 5,
    101162, Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.xgen.2026.101162">10.1016/j.xgen.2026.101162</a>.
  short: A. Depope, J. Bajzik, M. Mondelli, M.R. Robinson, Cell Genomics 6 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: "This project uses the UK Biobank data under project number
  35520. UK Biobank genotypic and phenotypic data are available through a formal request
  at http://www.ukbiobank.ac.uk. It also uses genotypic and phenotypic data from the
  All of Us study, which are also available through a formal request at https://www.researchallofus.org/data-tools/data-access/.
  All summary statistic estimates are released publicly on Dryad: https://doi.org/10.5061/dryad.cz8w9gjjc.\r\n•\r\nThe
  gVAMP code developed in this work is open source and has been deposited on GitHub,
  where it is publicly available at https://github.com/medical-genomics-group/gVAMP,
  and the code used to generate the data in the manuscript are available from Zenodo
  https://doi.org/10.5281/zenodo.17935521. The URLs of other software used are listed
  in the key resources table."
date_created: 2026-03-23T15:10:03Z
date_published: 2026-05-13T00:00:00Z
date_updated: 2026-07-28T07:08:15Z
day: '13'
ddc:
- '000'
- '570'
department:
- _id: MaMo
- _id: MaRo
doi: 10.1016/j.xgen.2026.101162
external_id:
  pmid:
  - '41713425'
file:
- access_level: open_access
  checksum: 6b59686f8d9733add4f23d23f3dd9df0
  content_type: application/pdf
  creator: dernst
  date_created: 2026-07-28T07:06:26Z
  date_updated: 2026-07-28T07:06:26Z
  file_id: '22596'
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file_date_updated: 2026-07-28T07:06:26Z
has_accepted_license: '1'
intvolume: '         6'
issue: '5'
language:
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license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
  name: Prix Lopez-Loretta 2019 - Marco Mondelli
- _id: 911e6d1f-16d5-11f0-9cad-c5c68c6a1cdf
  grant_number: '101161364'
  name: 'Inference in High Dimensions: Light-speed Algorithms and Information Limits'
- _id: 9B8D11D6-BA93-11EA-9121-9846C619BF3A
  grant_number: PCEGP3_181181
  name: Improving estimation and prediction of common complex disease risk
publication: Cell Genomics
publication_identifier:
  eissn:
  - 2666-979X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
  link:
  - description: News on ISTA website
    relation: press_release
    url: https://ista.ac.at/en/news/big-data-and-human-height/
  record:
  - id: '22258'
    relation: dissertation_contains
    status: public
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Joint modeling of whole-genome sequencing data for human height via approximate
  message passing
tmp:
  image: /images/cc_by_nc_nd.png
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  name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
_id: '22267'
abstract:
- lang: eng
  text: Thermal pollution, whether local or driven by global warming, threatens biodiversity
    in part through its detrimental effects on reproduction. Non-coding small RNAs
    (sRNAs) are crucial for maintaining germline developmental robustness under heat
    stress. Remarkably, we uncovered that neuronal sRNAs regulate germ cells’ thermotolerance,
    affecting both spermatogenic and oogenic germlines in a cell-non-autonomous manner.
    Furthermore, we demonstrate that, in RNAi mutants, an oxygen-sensing neural circuit,
    modulated by neuropeptide signaling, antagonizes germline maintenance, likely
    reflecting the nematode’s innate association of reduced oxygen levels with food
    availability and reproductive permissive environments. Finally, we provide evidence
    that laboratory-domesticated alleles of oxygen-response genes encoding neuropeptide
    receptor NPR-1 and hexacoordinated globin GLB-5 compromise germline thermotolerance.
    Hence, our findings raise the possibility that sensory perception, independent
    of direct environmental change, modulates germline integrity, highlighting a novel
    mechanism by which neural circuits integrate environmental information to safeguard
    reproductive fitness in fluctuating environments.
acknowledgement: We thank Itai Reiger for their assistance with experiments. We thank
  Cori Bargmann (Rockefeller University) for providing introgressed strains carrying
  HW alleles of npr-1 and glb-5. Some graphics were created with Biorender.com. We
  are grateful to WormBase for providing valuable data and resources. Some strains
  were provided by the Caenorhabditis Genetics Center (CGC), which is funded by NIH
  Office of Research Infrastructure Programs (P40 OD010440). O.R. is grateful for
  the support of the Morris Kahn Foundation. C.K.E. was supported by an EMBO fellowship
  ALTF 6-2022. This work is funded by Eric and Wendy Schmidt Fund for Strategic Innovation
  Polymath Award 0140001000 (O.R.); European Research Council grant 335624 (O.R.);
  Israel Science Foundation 979/21 (Y.B.T.); and the US-Israel Binational Science
  Foundation 2023036 (Y.B.T.).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Chee Kiang
  full_name: Ewe, Chee Kiang
  last_name: Ewe
- first_name: Hanna
  full_name: Achache, Hanna
  last_name: Achache
- first_name: Hanna
  full_name: Schön, Hanna
  id: C8E17EDC-D7AA-11E9-B7B7-45ECE5697425
  last_name: Schön
- first_name: Leonid
  full_name: Kontorovich, Leonid
  last_name: Kontorovich
- first_name: Guy
  full_name: Teichman, Guy
  last_name: Teichman
- first_name: Shir
  full_name: Weiss, Shir
  last_name: Weiss
- first_name: Anna
  full_name: Mogilevskaya, Anna
  last_name: Mogilevskaya
- first_name: Myriam
  full_name: Valenski, Myriam
  last_name: Valenski
- first_name: Sarit
  full_name: Anava, Sarit
  last_name: Anava
- first_name: Rutwik
  full_name: Bardapurkar, Rutwik
  last_name: Bardapurkar
- first_name: Hila
  full_name: Gingold, Hila
  last_name: Gingold
- first_name: Rachel
  full_name: Posner, Rachel
  last_name: Posner
- first_name: Olga
  full_name: Antonova, Olga
  last_name: Antonova
- first_name: Mario
  full_name: De Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: De Bono
  orcid: 0000-0001-8347-0443
- first_name: Yonatan B.
  full_name: Tzur, Yonatan B.
  last_name: Tzur
- first_name: Oded
  full_name: Rechavi, Oded
  last_name: Rechavi
citation:
  ama: Ewe CK, Achache H, Schön H, et al. Neuronal RNAi and oxygen-sensing circuit
    shape germline resilience to heat stress. <i>Current Biology</i>. 2026;36(14):3566-3579.e5.
    doi:<a href="https://doi.org/10.1016/j.cub.2026.06.016">10.1016/j.cub.2026.06.016</a>
  apa: Ewe, C. K., Achache, H., Schön, H., Kontorovich, L., Teichman, G., Weiss, S.,
    … Rechavi, O. (2026). Neuronal RNAi and oxygen-sensing circuit shape germline
    resilience to heat stress. <i>Current Biology</i>. Elsevier. <a href="https://doi.org/10.1016/j.cub.2026.06.016">https://doi.org/10.1016/j.cub.2026.06.016</a>
  chicago: Ewe, Chee Kiang, Hanna Achache, Hanna Schön, Leonid Kontorovich, Guy Teichman,
    Shir Weiss, Anna Mogilevskaya, et al. “Neuronal RNAi and Oxygen-Sensing Circuit
    Shape Germline Resilience to Heat Stress.” <i>Current Biology</i>. Elsevier, 2026.
    <a href="https://doi.org/10.1016/j.cub.2026.06.016">https://doi.org/10.1016/j.cub.2026.06.016</a>.
  ieee: C. K. Ewe <i>et al.</i>, “Neuronal RNAi and oxygen-sensing circuit shape germline
    resilience to heat stress,” <i>Current Biology</i>, vol. 36, no. 14. Elsevier,
    p. 3566–3579.e5, 2026.
  ista: Ewe CK, Achache H, Schön H, Kontorovich L, Teichman G, Weiss S, Mogilevskaya
    A, Valenski M, Anava S, Bardapurkar R, Gingold H, Posner R, Antonova O, de Bono
    M, Tzur YB, Rechavi O. 2026. Neuronal RNAi and oxygen-sensing circuit shape germline
    resilience to heat stress. Current Biology. 36(14), 3566–3579.e5.
  mla: Ewe, Chee Kiang, et al. “Neuronal RNAi and Oxygen-Sensing Circuit Shape Germline
    Resilience to Heat Stress.” <i>Current Biology</i>, vol. 36, no. 14, Elsevier,
    2026, p. 3566–3579.e5, doi:<a href="https://doi.org/10.1016/j.cub.2026.06.016">10.1016/j.cub.2026.06.016</a>.
  short: C.K. Ewe, H. Achache, H. Schön, L. Kontorovich, G. Teichman, S. Weiss, A.
    Mogilevskaya, M. Valenski, S. Anava, R. Bardapurkar, H. Gingold, R. Posner, O.
    Antonova, M. de Bono, Y.B. Tzur, O. Rechavi, Current Biology 36 (2026) 3566–3579.e5.
das_tickbox: '1'
dataavailabilitystatement: "* All NGS data are available through GEO under accession
  number GSE331410.\r\n* This paper does not report original code.\r\n* Any additional
  information required to reanalyze the data reported in this paper is available from
  the lead contact upon request."
date_created: 2026-07-12T22:02:18Z
date_published: 2026-07-20T00:00:00Z
date_updated: 2026-07-28T07:32:06Z
day: '20'
ddc:
- '570'
department:
- _id: MaDe
doi: 10.1016/j.cub.2026.06.016
external_id:
  pmid:
  - '42409014'
file:
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  date_created: 2026-07-28T07:31:44Z
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file_date_updated: 2026-07-28T07:31:44Z
has_accepted_license: '1'
intvolume: '        36'
issue: '14'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 3566-3579.e5
pmid: 1
publication: Current Biology
publication_identifier:
  eissn:
  - 1879-0445
  issn:
  - 0960-9822
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: upon request
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat
  stress
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21980'
abstract:
- lang: eng
  text: Despite significant progress in the field of molecular electronics over the
    last two decades, the quantitative prediction of metal-molecule-metal junction
    conductance remains a challenge. The standard computational framework combines
    density functional theory (DFT) with nonequilibrium Green’s functions (NEGF) using
    low-rung exchange-correlation functionals such as PBE, which overestimate the
    conductances. More advanced correction methods exist but require complex workflows
    and high computational cost, limiting their accessibility. Here, we introduce
    a physically motivated approach that approximates results obtained with high-rung
    functionals. Our method fits the PBE-calculated transmission to a Breit-Wigner
    form and subsequently refines the fit parameters using molecular orbital energies
    and metal densities of states computed for the isolated subsystems with high-rung
    functionals. This approach is applicable to a broad range of molecular junctions
    yielding conductance values in quantitative agreement with experiments. Our approach
    is simple, low-cost, and accurate, making it well-suited for routine and large-scale
    prediction of single-molecule junction conductance.
acknowledgement: This work was supported primarily by the Institute of Science and
  Technology Austria. L.V. was supported in part by the National Science Foundation
  (No. NSF-DMR 2241180). Z.-F.L. was supported by an NSF CAREER Award, No. DMR-2044552
  and an Alfred P. Sloan Research Fellowship, No. FG-2024-21750.
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Artem
  full_name: Gulyaev, Artem
  id: 83ed7901-7380-11f0-bf20-a0788d5e654d
  last_name: Gulyaev
- first_name: Jyotisman
  full_name: Hazarika, Jyotisman
  id: d87714c4-663d-11f0-bd06-caece19833e5
  last_name: Hazarika
  orcid: 0009-0007-2542-7878
- first_name: Zhen-Fei
  full_name: Liu, Zhen-Fei
  last_name: Liu
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
chemrxivid: 1
citation:
  ama: Gulyaev A, Hazarika J, Liu Z-F, Venkataraman L. A computationally efficient
    and accurate method for predicting conductance of single-molecule junctions. <i>Nano
    Letters</i>. 2026;26(22):7429–7434. doi:<a href="https://doi.org/10.1021/acs.nanolett.6c01462">10.1021/acs.nanolett.6c01462</a>
  apa: Gulyaev, A., Hazarika, J., Liu, Z.-F., &#38; Venkataraman, L. (2026). A computationally
    efficient and accurate method for predicting conductance of single-molecule junctions.
    <i>Nano Letters</i>. American Chemical Society. <a href="https://doi.org/10.1021/acs.nanolett.6c01462">https://doi.org/10.1021/acs.nanolett.6c01462</a>
  chicago: Gulyaev, Artem, Jyotisman Hazarika, Zhen-Fei Liu, and Latha Venkataraman.
    “A Computationally Efficient and Accurate Method for Predicting Conductance of
    Single-Molecule Junctions.” <i>Nano Letters</i>. American Chemical Society, 2026.
    <a href="https://doi.org/10.1021/acs.nanolett.6c01462">https://doi.org/10.1021/acs.nanolett.6c01462</a>.
  ieee: A. Gulyaev, J. Hazarika, Z.-F. Liu, and L. Venkataraman, “A computationally
    efficient and accurate method for predicting conductance of single-molecule junctions,”
    <i>Nano Letters</i>, vol. 26, no. 22. American Chemical Society, pp. 7429–7434,
    2026.
  ista: Gulyaev A, Hazarika J, Liu Z-F, Venkataraman L. 2026. A computationally efficient
    and accurate method for predicting conductance of single-molecule junctions. Nano
    Letters. 26(22), 7429–7434.
  mla: Gulyaev, Artem, et al. “A Computationally Efficient and Accurate Method for
    Predicting Conductance of Single-Molecule Junctions.” <i>Nano Letters</i>, vol.
    26, no. 22, American Chemical Society, 2026, pp. 7429–7434, doi:<a href="https://doi.org/10.1021/acs.nanolett.6c01462">10.1021/acs.nanolett.6c01462</a>.
  short: A. Gulyaev, J. Hazarika, Z.-F. Liu, L. Venkataraman, Nano Letters 26 (2026)
    7429–7434.
corr_author: '1'
das_tickbox: '1'
date_created: 2026-06-10T07:27:19Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-28T09:57:28Z
day: '01'
ddc:
- '540'
department:
- _id: LaVe
- _id: GradSch
doi: 10.1021/acs.nanolett.6c01462
external_id:
  chemrxivid:
  - 10.26434/chemrxiv.15001696
  pmid:
  - '42223342'
file:
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  date_created: 2026-06-16T09:11:35Z
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  success: 1
file_date_updated: 2026-06-16T09:11:35Z
has_accepted_license: '1'
intvolume: '        26'
issue: '22'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 7429–7434
pmid: 1
publication: Nano Letters
publication_identifier:
  eissn:
  - 1530-6992
  issn:
  - 1530-6984
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: A computationally efficient and accurate method for predicting conductance
  of single-molecule junctions
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 26
year: '2026'
...
---
OA_place: publisher
_id: '22017'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Tobias
  full_name: Kleinhanns, Tobias
  id: 8BD9DE16-AB3C-11E9-9C8C-2A03E6697425
  last_name: Kleinhanns
  orcid: 0000-0003-1537-7436
citation:
  ama: Kleinhanns T. Unraveling the origin and evolution of defects to enable advanced
    thermoelectric performance. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22017">10.15479/AT-ISTA-22017</a>
  apa: Kleinhanns, T. (2026). <i>Unraveling the origin and evolution of defects to
    enable advanced thermoelectric performance</i>. Institute of Science and Technology
    Austria. <a href="https://doi.org/10.15479/AT-ISTA-22017">https://doi.org/10.15479/AT-ISTA-22017</a>
  chicago: Kleinhanns, Tobias. “Unraveling the Origin and Evolution of Defects to
    Enable Advanced Thermoelectric Performance.” Institute of Science and Technology
    Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22017">https://doi.org/10.15479/AT-ISTA-22017</a>.
  ieee: T. Kleinhanns, “Unraveling the origin and evolution of defects to enable advanced
    thermoelectric performance,” Institute of Science and Technology Austria, 2026.
  ista: Kleinhanns T. 2026. Unraveling the origin and evolution of defects to enable
    advanced thermoelectric performance. Institute of Science and Technology Austria.
  mla: Kleinhanns, Tobias. <i>Unraveling the Origin and Evolution of Defects to Enable
    Advanced Thermoelectric Performance</i>. Institute of Science and Technology Austria,
    2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22017">10.15479/AT-ISTA-22017</a>.
  short: T. Kleinhanns, Unraveling the Origin and Evolution of Defects to Enable Advanced
    Thermoelectric Performance, Institute of Science and Technology Austria, 2026.
corr_author: '1'
das_tickbox: '1'
date_created: 2026-06-18T08:00:03Z
date_published: 2026-06-18T00:00:00Z
date_updated: 2026-07-28T09:55:13Z
day: '18'
ddc:
- '546'
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaIb
doi: 10.15479/AT-ISTA-22017
doi_confirm: '1'
file:
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  date_created: 2026-06-30T09:17:15Z
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  date_created: 2026-07-01T07:35:17Z
  date_updated: 2026-07-01T07:35:17Z
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  relation: main_file
file_date_updated: 2026-07-01T07:35:17Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa_version: Published Version
page: '59'
project:
- _id: 9B8F7476-BA93-11EA-9121-9846C619BF3A
  name: 'HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of
    Semiconductors for Waste Heat Recovery'
publication_identifier:
  isbn:
  - 978-3-99078-081-7
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '15182'
    relation: part_of_dissertation
    status: public
  - id: '12237'
    relation: part_of_dissertation
    status: public
  - id: '20326'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Maria
  full_name: Ibáñez, Maria
  id: 43C61214-F248-11E8-B48F-1D18A9856A87
  last_name: Ibáñez
  orcid: 0000-0001-5013-2843
title: Unraveling the origin and evolution of defects to enable advanced thermoelectric
  performance
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21009'
abstract:
- lang: eng
  text: We demonstrate that periodically driven quantum rotors provide a promising
    and broadly applicable platform to implement multigap topological phases, where
    groups of bands can acquire topological invariants due to non-Abelian braiding
    of band degeneracies. By adiabatically varying the periodic kicks to the rotor
    we find nodal-line braiding, which causes sign flips of topological charges of
    band nodes and can prevent them from annihilating, indicated by nonzero values
    of the patch Euler class. In particular, we report on the emergence of an anomalous
    Dirac string phase arising in the strongly driven regime, a truly out-of-equilibrium
    phase of the quantum rotor. This phase emanates from braiding processes involving
    all (quasienergy) gaps and manifests itself with edge states at zero angular momentum.
    Our results reveal direct applications in state-of-the-art experiments of quantum
    rotors, such as linear molecules driven by periodic far-off-resonant laser pulses
    or artificial quantum rotors in optical lattices, whose extensive versatility
    offers precise modification and observation of novel non-Abelian topological properties.
acknowledgement: We thank G. M. Koutentakis, S. Wimberger, J. G. E. Harris, T. Enss,
  and A. Ghazaryan for fruitful discussions. M.L. acknowledges support by the European
  Research Council (ERC) Starting Grant No. 801770 (ANGULON). R.-J.S. acknowledges
  funding from a EPSRC ERC underwrite (Grant No. EP/X025829/1), a EPSRC New Investigator
  Award (Grant No. EP/W00187X/1), and Trinity College, Cambridge. F.N.Ü. acknowledges
  support from the Marie Skłodowska-Curie Programme of the European Commission (Grant
  No. 893915), a Simons Investigator Award (Grant No. 511029), Trinity College Cambridge,
  and the Royal Society (Grant No. URF/R1/241667).
article_number: '012216'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Volker
  full_name: Karle, Volker
  id: D7C012AE-D7ED-11E9-95E8-1EC5E5697425
  last_name: Karle
  orcid: 0000-0002-6963-0129
- first_name: Mikhail
  full_name: Lemeshko, Mikhail
  id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
  last_name: Lemeshko
  orcid: 0000-0002-6990-7802
- first_name: Adrien
  full_name: Bouhon, Adrien
  last_name: Bouhon
- first_name: Robert-Jan
  full_name: Slager, Robert-Jan
  last_name: Slager
- first_name: F. Nur
  full_name: Ünal, F. Nur
  last_name: Ünal
citation:
  ama: Karle V, Lemeshko M, Bouhon A, Slager R-J, Ünal FN. Anomalous multigap topological
    phases in periodically driven quantum rotors. <i>Physical Review A</i>. 2026;113(1).
    doi:<a href="https://doi.org/10.1103/db9d-9bns">10.1103/db9d-9bns</a>
  apa: Karle, V., Lemeshko, M., Bouhon, A., Slager, R.-J., &#38; Ünal, F. N. (2026).
    Anomalous multigap topological phases in periodically driven quantum rotors. <i>Physical
    Review A</i>. American Physical Society. <a href="https://doi.org/10.1103/db9d-9bns">https://doi.org/10.1103/db9d-9bns</a>
  chicago: Karle, Volker, Mikhail Lemeshko, Adrien Bouhon, Robert-Jan Slager, and
    F. Nur Ünal. “Anomalous Multigap Topological Phases in Periodically Driven Quantum
    Rotors.” <i>Physical Review A</i>. American Physical Society, 2026. <a href="https://doi.org/10.1103/db9d-9bns">https://doi.org/10.1103/db9d-9bns</a>.
  ieee: V. Karle, M. Lemeshko, A. Bouhon, R.-J. Slager, and F. N. Ünal, “Anomalous
    multigap topological phases in periodically driven quantum rotors,” <i>Physical
    Review A</i>, vol. 113, no. 1. American Physical Society, 2026.
  ista: Karle V, Lemeshko M, Bouhon A, Slager R-J, Ünal FN. 2026. Anomalous multigap
    topological phases in periodically driven quantum rotors. Physical Review A. 113(1),
    012216.
  mla: Karle, Volker, et al. “Anomalous Multigap Topological Phases in Periodically
    Driven Quantum Rotors.” <i>Physical Review A</i>, vol. 113, no. 1, 012216, American
    Physical Society, 2026, doi:<a href="https://doi.org/10.1103/db9d-9bns">10.1103/db9d-9bns</a>.
  short: V. Karle, M. Lemeshko, A. Bouhon, R.-J. Slager, F.N. Ünal, Physical Review
    A 113 (2026).
corr_author: '1'
date_created: 2026-01-20T10:06:07Z
date_published: 2026-01-12T00:00:00Z
date_updated: 2026-07-29T08:59:30Z
day: '12'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1103/db9d-9bns
ec_funded: 1
external_id:
  arxiv:
  - '2408.16848'
file:
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  creator: dernst
  date_created: 2026-01-21T09:04:48Z
  date_updated: 2026-01-21T09:04:48Z
  file_id: '21029'
  file_name: 2026_PhysicalReviewA_Karle.pdf
  file_size: 2650256
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  success: 1
file_date_updated: 2026-01-21T09:04:48Z
has_accepted_license: '1'
intvolume: '       113'
issue: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 2688CF98-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '801770'
  name: 'Angulon: physics and applications of a new quasiparticle'
publication: Physical Review A
publication_identifier:
  eissn:
  - 2469-9934
  issn:
  - 2469-9926
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
  record:
  - id: '19425'
    relation: earlier_version
    status: public
scopus_import: '1'
status: public
title: Anomalous multigap topological phases in periodically driven quantum rotors
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 113
year: '2026'
...
---
OA_type: closed access
_id: '21406'
abstract:
- lang: eng
  text: 'This preliminary study investigates the trace-element composition of ostracod
    shells (Ostracoda: Crustacea) as biogenic calcium carbonates in their role as
    environmental sentinels of pollution. Using high-resolution in-situ analysis,
    we compared two contrasting coastal systems: the highly urbanized seascape of
    metropolitan megacity Hong Kong (HKSAR) and the agriculturally dominated waters
    of rural retreat Jeju Island, Republic of Korea (ROK). The goal was to assess
    whether anthropogenic stress gradients affect trace element-to‑calcium ratios
    (E/Ca) in the carapaces of shallow-marine Neonesidea Maddocks, 1969 species. Hereby,
    the focus is laid on potential differences in the effects of extreme urbanization
    and extreme agriculturalization. We analyzed 12 trace elements commonly incorporated
    into ostracod shells using Inductively Coupled Plasma–Mass Spectrometry (ICP-MS).
    Only Mn/Ca, Mg/Ca, and Ni/Ca ratios showed strong correlations with specific seawater
    physicochemical parameters. Notably, Mn/Ca differed significantly between the
    two sites, seemingly driven mainly by variations in nitrite nitrogen levels. This
    suggests that Mn incorporation is sensitive to pollution source, urban versus
    agricultural, though species-specific uptake effects cannot be excluded. No significant
    differences in elemental uptake were found between adult and A-1 juvenile stages
    of Neonesidea mutsuensis Ishizaki, 1961 or Neonesidea elegans (Brady, 1969), supporting
    the use of both age groups in environmental reconstructions and increasing potential
    sample yields. While remaining empirical and exploratory, our tentative findings
    suggest that ostracod geochemistry holds promise for marine pollution monitoring
    and cautiously supports the application of ostracod Mn/Ca ratios to reconstruct
    anthropogenic, particularly nitrogen-related, impacts in nearshore environments
    using sediment core records.'
acknowledgement: 'We thank the KIOST staff of the Jeju Marine Research Center for
  assisting sample collection, the research assistants and students of the Yoon Idea
  Lab led by Prof. Dr. Tae-Hyun Yoon at Hanyang University for facilitating and assisting
  in ICP-MS test runs involved in a pilot study preceding this study, Ms. Garance
  Perrois and Mr. Léonard Pons for assistance with statistics-related questions, and
  the two anonymous reviewers for their valuable comments and suggestions. The study
  described in this article was partially supported by grants from the Brain Pool
  Program through NRF funded by the Ministry of Science and ICT (reference code: 2019H1D3A1A01070922
  to ABJ), by the Ministry of Oceans and Fisheries (grant number RS-2024-00406249
  to TK), by the Korea Institute of Marine Science and Technology (KIMST), funded
  by the Ministry of Oceans and Fisheries (grant number RS-2025-02304432 to TK), and
  by the Korea Institute of Ocean Science and Technology (PEA0404 to TK).'
article_number: '119493'
article_processing_charge: No
article_type: original
author:
- first_name: Anna B.
  full_name: Jöst, Anna B.
  last_name: Jöst
- first_name: Maximiliano J
  full_name: Rodriguez Moreno, Maximiliano J
  id: 59bea3b2-8c82-11ef-a41a-af7b0efd9065
  last_name: Rodriguez Moreno
- first_name: Taihun
  full_name: Kim, Taihun
  last_name: Kim
- first_name: David M.
  full_name: Baker, David M.
  last_name: Baker
- first_name: Moriaki
  full_name: Yasuhara, Moriaki
  last_name: Yasuhara
- first_name: Christelle A.
  full_name: Not, Christelle A.
  last_name: Not
- first_name: Ivana
  full_name: Karanovic, Ivana
  last_name: Karanovic
citation:
  ama: Jöst AB, Rodriguez Moreno MJ, Kim T, et al. Ostracod shell chemistry as proxy
    for coastal marine conditions of a highly urbanized megacity (Hong Kong SAR) and
    an agro-centric oceanic province (Jeju Island, Republic of Korea) – a preliminary
    comparative analysis. <i>Marine Pollution Bulletin</i>. 2026;227(6). doi:<a href="https://doi.org/10.1016/j.marpolbul.2026.119493">10.1016/j.marpolbul.2026.119493</a>
  apa: Jöst, A. B., Rodriguez Moreno, M. J., Kim, T., Baker, D. M., Yasuhara, M.,
    Not, C. A., &#38; Karanovic, I. (2026). Ostracod shell chemistry as proxy for
    coastal marine conditions of a highly urbanized megacity (Hong Kong SAR) and an
    agro-centric oceanic province (Jeju Island, Republic of Korea) – a preliminary
    comparative analysis. <i>Marine Pollution Bulletin</i>. Elsevier. <a href="https://doi.org/10.1016/j.marpolbul.2026.119493">https://doi.org/10.1016/j.marpolbul.2026.119493</a>
  chicago: Jöst, Anna B., Maximiliano J Rodriguez Moreno, Taihun Kim, David M. Baker,
    Moriaki Yasuhara, Christelle A. Not, and Ivana Karanovic. “Ostracod Shell Chemistry
    as Proxy for Coastal Marine Conditions of a Highly Urbanized Megacity (Hong Kong
    SAR) and an Agro-Centric Oceanic Province (Jeju Island, Republic of Korea) – a
    Preliminary Comparative Analysis.” <i>Marine Pollution Bulletin</i>. Elsevier,
    2026. <a href="https://doi.org/10.1016/j.marpolbul.2026.119493">https://doi.org/10.1016/j.marpolbul.2026.119493</a>.
  ieee: A. B. Jöst <i>et al.</i>, “Ostracod shell chemistry as proxy for coastal marine
    conditions of a highly urbanized megacity (Hong Kong SAR) and an agro-centric
    oceanic province (Jeju Island, Republic of Korea) – a preliminary comparative
    analysis,” <i>Marine Pollution Bulletin</i>, vol. 227, no. 6. Elsevier, 2026.
  ista: Jöst AB, Rodriguez Moreno MJ, Kim T, Baker DM, Yasuhara M, Not CA, Karanovic
    I. 2026. Ostracod shell chemistry as proxy for coastal marine conditions of a
    highly urbanized megacity (Hong Kong SAR) and an agro-centric oceanic province
    (Jeju Island, Republic of Korea) – a preliminary comparative analysis. Marine
    Pollution Bulletin. 227(6), 119493.
  mla: Jöst, Anna B., et al. “Ostracod Shell Chemistry as Proxy for Coastal Marine
    Conditions of a Highly Urbanized Megacity (Hong Kong SAR) and an Agro-Centric
    Oceanic Province (Jeju Island, Republic of Korea) – a Preliminary Comparative
    Analysis.” <i>Marine Pollution Bulletin</i>, vol. 227, no. 6, 119493, Elsevier,
    2026, doi:<a href="https://doi.org/10.1016/j.marpolbul.2026.119493">10.1016/j.marpolbul.2026.119493</a>.
  short: A.B. Jöst, M.J. Rodriguez Moreno, T. Kim, D.M. Baker, M. Yasuhara, C.A. Not,
    I. Karanovic, Marine Pollution Bulletin 227 (2026).
das_tickbox: '1'
dataavailabilitystatement: The datasets analysed during the current study are available
  within the manuscript and the associated supplementary materials.
date_created: 2026-03-08T23:01:44Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-07-29T10:09:31Z
day: '01'
department:
- _id: FrPe
doi: 10.1016/j.marpolbul.2026.119493
external_id:
  pmid:
  - '41774948'
intvolume: '       227'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
pmid: 1
publication: Marine Pollution Bulletin
publication_identifier:
  eissn:
  - 1879-3363
  issn:
  - 002-5326X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Ostracod shell chemistry as proxy for coastal marine conditions of a highly
  urbanized megacity (Hong Kong SAR) and an agro-centric oceanic province (Jeju Island,
  Republic of Korea) – a preliminary comparative analysis
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 227
year: '2026'
...
