---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22712'
abstract:
- lang: eng
  text: Ginseng (Panax ginseng) derives its renowned therapeutic properties from ginsenoside
    metabolites. However, the long cultivation cycle and susceptibility to diseases
    hinder the advancement of the ginseng industry. Here, we demonstrate that the
    embryonic protoderm of ginseng can efficiently produce ginsenosides. Single-cell
    transcriptome and mass spectrometry imaging analyses reveal that ginsenosides
    accumulate in the protoderm of ginseng embryonic callus (EC) at levels comparable
    to those in forest ginseng. Epigenetic analyses indicate that elevated histone
    acetylation and enhanced chromatin accessibility at regeneration- and ginsenoside
    metabolism-related gene loci are associated with the ginsenoside-producing capacity
    of EC. Increasing histone acetylation levels or overexpressing the regeneration-related
    WUSCHEL-RELATED HOMEOBOX11 (WOX11) gene further enhances ginsenoside production
    in EC. Our findings suggest that the protoderm of EC could serve as an in situ
    biological compartment for high-efficiency ginsenoside producion, offering a complementary
    approach to traditional ginseng cultivation.
acknowledgement: 'The authors are grateful to Professor Linfeng Li from the School
  of Life Science, Fudan University, for his assistance during the ginseng genome
  annotation. This work was supported by Key project at central government level:
  The ability establishment of sustainable use for valuable Chinese medicine resources
  (2060302-2401-08 to L.X. and J.L.), the National Natural Science Foundation of China
  (82373987 to J.L., 31701294 to L.X., 32225007 to L.X., and 32300285 to N.Z.), the
  Fundamental Research Funds for the Central public welfare research institutes (ZZ13-YQ-093,
  ZZXT202508 to J.L.), the CACMS Innovation Fund (CI2025G00-06 to J.L.), the Principle
  Investigator Program (HBMUPI202104 to Y.Z.), the Key R&D Program of Shandong Province,
  China (2024LZGC025 to L.X.), the National Key R&D Program of China (2024YFF1000700/2023YFE0101100
  to L.X.), Strategic Priority Research Program of Chinese Academy of Sciences (XDB0630000
  to L.X.), and China Postdoctoral Science Foundation (2023M733490 to N.Z.).'
article_number: '7994'
article_processing_charge: Yes
article_type: original
author:
- first_name: Juan
  full_name: Liu, Juan
  last_name: Liu
- first_name: Ning
  full_name: Zhai, Ning
  last_name: Zhai
- first_name: Shiyi
  full_name: Zhang, Shiyi
  last_name: Zhang
- first_name: Yosuke
  full_name: Tamada, Yosuke
  last_name: Tamada
- first_name: Tonghui
  full_name: Li, Tonghui
  last_name: Li
- first_name: Linfan
  full_name: Zhang, Linfan
  last_name: Zhang
- first_name: Tong
  full_name: Chen, Tong
  last_name: Chen
- first_name: Chenglin
  full_name: Wang, Chenglin
  last_name: Wang
- first_name: Jian
  full_name: Yang, Jian
  last_name: Yang
- first_name: Jiaqi
  full_name: Gao, Jiaqi
  last_name: Gao
- first_name: Xiang
  full_name: Li, Xiang
  id: 4B7E523C-F248-11E8-B48F-1D18A9856A87
  last_name: Li
- first_name: Junhui
  full_name: Zhou, Junhui
  last_name: Zhou
- first_name: Yonghong
  full_name: Zhang, Yonghong
  last_name: Zhang
- first_name: Yu
  full_name: Liu, Yu
  id: 2A70014E-F248-11E8-B48F-1D18A9856A87
  last_name: Liu
  orcid: 0000-0001-7313-6740
- first_name: Yuan
  full_name: Wang, Yuan
  last_name: Wang
- first_name: Jiří
  full_name: Friml, Jiří
  id: 4159519E-F248-11E8-B48F-1D18A9856A87
  last_name: Friml
  orcid: 0000-0002-8302-7596
- first_name: Eva
  full_name: Benková, Eva
  id: 38F4F166-F248-11E8-B48F-1D18A9856A87
  last_name: Benková
  orcid: 0000-0002-8510-9739
- first_name: Chen
  full_name: Li, Chen
  last_name: Li
- first_name: Lin
  full_name: Xu, Lin
  last_name: Xu
- first_name: Luqi
  full_name: Huang, Luqi
  last_name: Huang
citation:
  ama: Liu J, Zhai N, Zhang S, et al. Single-cell analyses identify the ginseng embryonic
    protoderm as a native compartment for high-efficiency ginsenoside production.
    <i>Nature Communications</i>. 2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-74881-5">10.1038/s41467-026-74881-5</a>
  apa: Liu, J., Zhai, N., Zhang, S., Tamada, Y., Li, T., Zhang, L., … Huang, L. (2026).
    Single-cell analyses identify the ginseng embryonic protoderm as a native compartment
    for high-efficiency ginsenoside production. <i>Nature Communications</i>. Springer
    Nature. <a href="https://doi.org/10.1038/s41467-026-74881-5">https://doi.org/10.1038/s41467-026-74881-5</a>
  chicago: Liu, Juan, Ning Zhai, Shiyi Zhang, Yosuke Tamada, Tonghui Li, Linfan Zhang,
    Tong Chen, et al. “Single-Cell Analyses Identify the Ginseng Embryonic Protoderm
    as a Native Compartment for High-Efficiency Ginsenoside Production.” <i>Nature
    Communications</i>. Springer Nature, 2026. <a href="https://doi.org/10.1038/s41467-026-74881-5">https://doi.org/10.1038/s41467-026-74881-5</a>.
  ieee: J. Liu <i>et al.</i>, “Single-cell analyses identify the ginseng embryonic
    protoderm as a native compartment for high-efficiency ginsenoside production,”
    <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.
  ista: Liu J, Zhai N, Zhang S, Tamada Y, Li T, Zhang L, Chen T, Wang C, Yang J, Gao
    J, Li X, Zhou J, Zhang Y, Liu Y, Wang Y, Friml J, Benková E, Li C, Xu L, Huang
    L. 2026. Single-cell analyses identify the ginseng embryonic protoderm as a native
    compartment for high-efficiency ginsenoside production. Nature Communications.
    17, 7994.
  mla: Liu, Juan, et al. “Single-Cell Analyses Identify the Ginseng Embryonic Protoderm
    as a Native Compartment for High-Efficiency Ginsenoside Production.” <i>Nature
    Communications</i>, vol. 17, 7994, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-74881-5">10.1038/s41467-026-74881-5</a>.
  short: J. Liu, N. Zhai, S. Zhang, Y. Tamada, T. Li, L. Zhang, T. Chen, C. Wang,
    J. Yang, J. Gao, X. Li, J. Zhou, Y. Zhang, Y. Liu, Y. Wang, J. Friml, E. Benková,
    C. Li, L. Xu, L. Huang, Nature Communications 17 (2026).
das_tickbox: '1'
dataavailabilitystatement: The RNA-seq data generated in this study have been deposited
  in the GSA database under accession code CRA008967. The scRNA-seq data generated
  in this study have been deposited in the GSA database under accession code CRA026200.
  The ATAC-seq data generated in this study have been deposited in the GSA database
  under accession code CRA008969. The ChIP-seq data generated in this study have been
  deposited in the GSA database under accession code CRA008968. Single-cell RNA-seq
  data and scripts are publicly available on Zenodo (https://zenodo.org/records/20392012).
  Primers are in Supplemental Table 5. Source data are provided with this paper.
date_created: 2026-08-16T22:01:42Z
date_published: 2026-08-07T00:00:00Z
date_updated: 2026-08-20T06:45:46Z
day: '07'
ddc:
- '580'
department:
- _id: JiFr
- _id: EvBe
doi: 10.1038/s41467-026-74881-5
external_id:
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  - '42350386'
file:
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  date_created: 2026-08-20T06:44:33Z
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language:
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month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Single-cell analyses identify the ginseng embryonic protoderm as a native compartment
  for high-efficiency ginsenoside production
tmp:
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  short: CC BY-NC-ND (4.0)
type: journal_article
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volume: 17
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '22711'
abstract:
- lang: eng
  text: When charge flows through a molecular circuit, it induces a magnetic field
    that allows the circuit to behave as a nanoscale electromagnet. However, in single-molecule
    circuits this magnetic field is usually weak. Here we show that radially π-conjugated
    carbon structures can support amplified circulating currents that generate local
    magnetic fields. Within tight-binding and density functional theory (DFT) frameworks,
    we first study cycloparaphenylene (CPP) junctions where both electrodes are attached
    to the same phenylene unit on the nanohoop. We observe an energy-dependent ring
    current component that traverses the whole macrocycle by mapping the local current
    density. Importantly, we find that destructive interference near degenerate resonances
    can reverse the ring current direction and amplify it strongly relative to the
    source–drain current. We show that this interference-driven design principle is
    general, and also carries over to C60 junctions. In fullerene, lower-lying degenerate
    resonances are more easily accessible through electrostatic gating, reaching a
    magnetic field of 14.2 mT under a 100 mV source–drain bias. This work thus provides
    new insights into ring currents in radially π-conjugated carbon structures and
    highlights their potential as design platforms for single-molecule electromagnets.
acknowledgement: The authors thank Jascha Repp from the University of Regensburg for
  helpful discussions. This paper is dedicated to the memory of Prof. Mark Ratner
  in appreciation of the encouragement offered many years ago, and whose influence
  had endured ever since. This work was supported by the National Science Foundation
  under grant NSF-DMR 2241180 and the Institute of Science and Technology Austria.
  The collaboration between L.V., R.K., and F.E. was supported by the Humboldt Foundation.
  This research was funded in part by the Austrian Science Fund (FWF) [10.55776/COE5]
  (Cluster of Excellence MECS).
article_number: '7916'
article_processing_charge: Yes
article_type: original
author:
- first_name: Wanzhuo
  full_name: Shi, Wanzhuo
  id: a3010425-87c8-11f0-8106-bec32bea74da
  last_name: Shi
- first_name: Richard
  full_name: Korytár, Richard
  last_name: Korytár
- first_name: Ferdinand
  full_name: Evers, Ferdinand
  last_name: Evers
- first_name: John D.
  full_name: Tovar, John D.
  last_name: Tovar
- first_name: Latha
  full_name: Venkataraman, Latha
  id: 9ebb78a5-cc0d-11ee-8322-fae086a32caf
  last_name: Venkataraman
  orcid: 0000-0002-6957-6089
citation:
  ama: Shi W, Korytár R, Evers F, Tovar JD, Venkataraman L. Designing effective single-molecule
    electromagnets with radially π-conjugated carbon structures. <i>Nature Communications</i>.
    2026;17. doi:<a href="https://doi.org/10.1038/s41467-026-74365-6">10.1038/s41467-026-74365-6</a>
  apa: Shi, W., Korytár, R., Evers, F., Tovar, J. D., &#38; Venkataraman, L. (2026).
    Designing effective single-molecule electromagnets with radially π-conjugated
    carbon structures. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-026-74365-6">https://doi.org/10.1038/s41467-026-74365-6</a>
  chicago: Shi, Wanzhuo, Richard Korytár, Ferdinand Evers, John D. Tovar, and Latha
    Venkataraman. “Designing Effective Single-Molecule Electromagnets with Radially
    π-Conjugated Carbon Structures.” <i>Nature Communications</i>. Springer Nature,
    2026. <a href="https://doi.org/10.1038/s41467-026-74365-6">https://doi.org/10.1038/s41467-026-74365-6</a>.
  ieee: W. Shi, R. Korytár, F. Evers, J. D. Tovar, and L. Venkataraman, “Designing
    effective single-molecule electromagnets with radially π-conjugated carbon structures,”
    <i>Nature Communications</i>, vol. 17. Springer Nature, 2026.
  ista: Shi W, Korytár R, Evers F, Tovar JD, Venkataraman L. 2026. Designing effective
    single-molecule electromagnets with radially π-conjugated carbon structures. Nature
    Communications. 17, 7916.
  mla: Shi, Wanzhuo, et al. “Designing Effective Single-Molecule Electromagnets with
    Radially π-Conjugated Carbon Structures.” <i>Nature Communications</i>, vol. 17,
    7916, Springer Nature, 2026, doi:<a href="https://doi.org/10.1038/s41467-026-74365-6">10.1038/s41467-026-74365-6</a>.
  short: W. Shi, R. Korytár, F. Evers, J.D. Tovar, L. Venkataraman, Nature Communications
    17 (2026).
corr_author: '1'
das_tickbox: '1'
dataavailabilitystatement: The data generated in this study have been deposited in
  the Code Ocean capsule. The capsule contains the FHI-aims and AITRANSS output matrices
  used for post-processing, precomputed cache files, and optimized atomic coordinate
  files. These data are sufficient to reproduce the results reported in the paper.
  The code used to reproduce the local-current and magnetic-field analyses is available
  in the Code Ocean capsule. The capsule includes Python scripts for post-processing
  DFT output matrices and Mathematica notebooks for tight-binding calculations and
  reproducing visualizations.
date_created: 2026-08-16T22:01:42Z
date_published: 2026-08-06T00:00:00Z
date_updated: 2026-08-20T06:40:49Z
day: '06'
ddc:
- '530'
department:
- _id: LaVe
doi: 10.1038/s41467-026-74365-6
external_id:
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  - '42277037'
file:
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has_accepted_license: '1'
intvolume: '        17'
language:
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month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
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publication_status: published
publisher: Springer Nature
quality_controlled: '1'
researchdata_availability: yes
scopus_import: '1'
status: public
supplementarymaterial: yes
title: Designing effective single-molecule electromagnets with radially π-conjugated
  carbon structures
tmp:
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  short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2026'
...
---
OA_place: repository
_id: '22687'
abstract:
- lang: eng
  text: "Understanding enzyme function requires characterizing not only static structure
    but also dynamics and ligand interactions. NMR spectroscopy provides this insight
    at atomic resolution, yet for large proteins the difficulty of resonance assignment
    has largely confined such studies to systems below ∼50 kDa, or to observing only
    methyl groups. Here we present an integrated magic-angle spinning (MAS) and solution
    NMR study of the 134 kDa tetrameric malate dehydrogenase from Ignicoccus islandicus
    (IiMDH), an enzyme of particular interest as an evolutionary intermediate between
    allosteric lactate\r\ndehydrogenases and non-allosteric malate dehydrogenases.
    By combining high-dimensional (up to 4D) MAS NMR experiments on sedimented protein
    with solution NMR, we achieved 92% backbone heavy- atom assignment and 91% assignment
    of all Ile-δ1, Leu-δ1/-δ2, Val-γ1/-γ2, Met-ε and Thr-γ methyl groups. Building
    on these assignments, we use various probes of backbone and sidechain dynamics:
    elevated MAS NMR 15N rotating-frame relaxation (R1ρ) points to microsecond motions
    in functionally critical regions, including the catalytic loop and the mobile
    surface loop. Complementary methyl-axis order parameters from solution NMR identified
    additional flexible sites in the hydrophobic core. Chemical shift perturbation
    experiments upon addition of the substrate analogue oxamate, monitored via backbone
    1H-15N TROSY, revealed both active-site contacts and responses in helices α2F
    and α3G, regions implicated in allosteric signal transmission. The integrated
    approach demonstrated here exploits the distinct strengths of MAS and solution
    NMR, and provides a comprehensive view of structure, dynamics, and substrate interactions
    in a large oligomeric enzyme that would not be accessible by either technique
    alone."
acknowledged_ssus:
- _id: NMR
- _id: LifeSc
acknowledgement: This research was supported by the Scientific Service Units (SSU)
  of Institute of Science and Technology Austria (ISTA) through resources provided
  by the Nuclear Magnetic Resonance and the Lab Support Facilities. We thank Petra
  Rovó, Megha Mohan and Margarita Valhondo Falcón for excellent support of the NMR
  facility.
article_processing_charge: No
author:
- first_name: Paul
  full_name: Schanda, Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- first_name: Federico
  full_name: Napoli, Federico
  id: d42e08e7-f4fc-11eb-af0a-d71e26138f1b
  last_name: Napoli
  orcid: 0000-0002-9043-136X
citation:
  ama: 'Schanda P, Napoli F. Data and scripts for: “Integrated solid/solution NMR
    assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.” 2026.
    doi:<a href="https://doi.org/10.15479/AT-ISTA-22687">10.15479/AT-ISTA-22687</a>'
  apa: 'Schanda, P., &#38; Napoli, F. (2026). Data and scripts for: “Integrated solid/solution
    NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.”
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22687">https://doi.org/10.15479/AT-ISTA-22687</a>'
  chicago: 'Schanda, Paul, and Federico Napoli. “Data and Scripts for: ‘Integrated
    Solid/Solution NMR Assignment Allows Mapping Dynamics and Ligand Binding in a
    134 KDa Enzyme.’” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22687">https://doi.org/10.15479/AT-ISTA-22687</a>.'
  ieee: 'P. Schanda and F. Napoli, “Data and scripts for: ‘Integrated solid/solution
    NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme.’”
    Institute of Science and Technology Austria, 2026.'
  ista: 'Schanda P, Napoli F. 2026. Data and scripts for: ‘Integrated solid/solution
    NMR assignment allows mapping dynamics and ligand binding in a 134 kDa enzyme’,
    Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-22687">10.15479/AT-ISTA-22687</a>.'
  mla: 'Schanda, Paul, and Federico Napoli. <i>Data and Scripts for: “Integrated Solid/Solution
    NMR Assignment Allows Mapping Dynamics and Ligand Binding in a 134 KDa Enzyme.”</i>
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22687">10.15479/AT-ISTA-22687</a>.'
  short: P. Schanda, F. Napoli, (2026).
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  id: d42e08e7-f4fc-11eb-af0a-d71e26138f1b
  last_name: Napoli
  orcid: 0000-0002-9043-136X
- contributor_type: project_leader
  first_name: Paul
  id: 7B541462-FAF6-11E9-A490-E8DFE5697425
  last_name: Schanda
  orcid: 0000-0002-9350-7606
- contributor_type: project_member
  first_name: Rajkumar
  id: a3089acd-6806-11ee-bacc-f0c7d500ad20
  last_name: Singh
- contributor_type: project_member
  first_name: Anna
  id: 9fb2a840-89e1-11ee-a8b7-cc5c7ba62471
  last_name: Kapitonova
- contributor_type: project_member
  first_name: Virgil
  last_name: Aitenbichler
- contributor_type: project_member
  first_name: Giorgia
  id: 334a5e40-8747-11f0-b671-ba1f5154b4b4
  last_name: Toscano
- contributor_type: data_collector
  first_name: Barbara
  last_name: Perrone
corr_author: '1'
date_created: 2026-08-12T16:12:19Z
date_published: 2026-08-20T00:00:00Z
date_updated: 2026-08-20T07:40:15Z
day: '20'
department:
- _id: PaSc
doi: 10.15479/AT-ISTA-22687
doi_confirm: '1'
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month: '08'
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project:
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  grant_number: I05812
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publisher: Institute of Science and Technology Austria
status: public
title: 'Data and scripts for: "Integrated solid/solution NMR assignment allows mapping
  dynamics and ligand binding in a 134 kDa enzyme"'
tmp:
  image: /images/cc_by_nc.png
  legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
  name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
  short: CC BY-NC (4.0)
type: research_data
user_id: 68b8ca59-c5b3-11ee-8790-cd641c68093d
year: '2026'
...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '21746'
abstract:
- lang: eng
  text: As vertebrates transitioned from water to land, locomotion shifted from undulatory
    swimming to limb-based movement. How spinal circuits and their cell types evolved
    to support this transition remains unclear. We leverage frog metamorphosis, which
    recapitulates this transition within a single organism, to define how spinal circuits
    generate aquatic versus terrestrial motor patterns. At swim stages, spinal architecture
    is uniform, with a transcriptionally and anatomically homogeneous motor and interneurons.
    As limbs develop and their movement complexifies, spinal circuits expand in neuron
    number and subtype diversity. This expansion is most pronounced for V1 inhibitory
    neurons, which increase ∼70-fold and diversify into transcriptionally distinct
    subtypes. Disrupting transcription factors defining emerging motor and V1 populations
    reveals molecular segregation between swim and limb circuits, highlighting the
    role of subtype diversity in motor coordination. A multifold increase in inhibitory
    neuron diversity thus underlies the tail-to-limb locomotor transition, providing
    a framework for spinal circuit adaptation during vertebrate evolution.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: 'We would like to thank the members of the Sweeney Lab, Mario de
  Bono, Michael Forsthofer, Katharina Lust, and Meital Oren, for comments on the manuscript.
  We are also grateful to Tom Jessell and Chris Kintner for their scientific insight
  and mentorship during the conception of this project. It would also have not been
  possible without the technical support of the Aquatics and Imaging and Optics Facility
  support teams (ISTA). We thank Martin Estermann for preparing the initial draft
  of the graphical abstract and Niki Barolini for the final version. In addition,
  we thank our funding sources for providing the resources to do these experiments:
  GFF NÖ FTI Strategy Lower Austria dissertation grant FT121-D-046 (to D.V.), Horizon
  Europe ERC starting grant 101041551 (to Y.I., L.B.S., F.A.T., and D.V.), Special
  Research Program (SFB) of the Austrian Science Fund (FWF) project F7814-B (to L.B.S.),
  Austrian Science Fund (FWF) 10.55776/COE16 (to Y.I. and L.B.S.), NINDS 5R35NS116858
  (to J.S.D.), CZI grant DAF2020-225401 (DOI) 10.37921/120055ratwvi (to R.H.), NIH
  grant R01NS123116 (to J.B.B.), American Lebanese Syrian Associated Charities (ALSAC)
  (to J.B.B.), German Academic Exchange Service (DAAD) IFI grant 57515251-91853472
  (to Z.H.), and Project A.L.S. (to S.B.-M.).'
article_number: '117227'
article_processing_charge: Yes
article_type: original
author:
- first_name: David
  full_name: Vijatovic, David
  id: cf391e77-ec3c-11ea-a124-d69323410b58
  last_name: Vijatovic
  orcid: 0000-0002-5494-0941
- first_name: 'Florina Alexandra '
  full_name: 'Toma, Florina Alexandra '
  id: 2f73f876-f128-11eb-9611-b96b5a30cb0e
  last_name: Toma
- first_name: Y
  full_name: Ignatyev, Y
  last_name: Ignatyev
- first_name: Zoe P
  full_name: Harrington, Zoe P
  id: a8144562-32c9-11ee-b5ce-d9800628bda2
  last_name: Harrington
  orcid: 0009-0008-0158-4032
- first_name: Christoph M
  full_name: Sommer, Christoph M
  id: 4DF26D8C-F248-11E8-B48F-1D18A9856A87
  last_name: Sommer
  orcid: 0000-0003-1216-9105
- first_name: Robert
  full_name: Hauschild, Robert
  id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
  last_name: Hauschild
  orcid: 0000-0001-9843-3522
- first_name: Matthijs Geert
  full_name: Smits, Matthijs Geert
  id: 7a231d52-e216-11ee-a0bb-8acd55f8f1f0
  last_name: Smits
- first_name: Marco
  full_name: Dalla Vecchia, Marco
  id: 02a7a869-ff06-11ed-a87f-86649d6077e5
  last_name: Dalla Vecchia
- first_name: Alexandra J.
  full_name: Trevisan, Alexandra J.
  last_name: Trevisan
- first_name: Phillip
  full_name: Chapman, Phillip
  last_name: Chapman
- first_name: Mara
  full_name: Julseth, Mara
  id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
  last_name: Julseth
- first_name: Susan
  full_name: Brenner-Morton, Susan
  last_name: Brenner-Morton
- first_name: Mariano I.
  full_name: Gabitto, Mariano I.
  last_name: Gabitto
- first_name: Jeremy S.
  full_name: Dasen, Jeremy S.
  last_name: Dasen
- first_name: Jay B.
  full_name: Bikoff, Jay B.
  last_name: Bikoff
- first_name: Lora Beatrice Jaeger
  full_name: Sweeney, Lora Beatrice Jaeger
  id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
  last_name: Sweeney
  orcid: 0000-0001-9242-5601
citation:
  ama: Vijatovic D, Toma FA, Ignatyev Y, et al. Multifold increase in spinal inhibitory
    cell types with emergence of limb movement. <i>Cell Reports</i>. 2026;45(4). doi:<a
    href="https://doi.org/10.1016/j.celrep.2026.117227">10.1016/j.celrep.2026.117227</a>
  apa: Vijatovic, D., Toma, F. A., Ignatyev, Y., Harrington, Z. P., Sommer, C. M.,
    Hauschild, R., … Sweeney, L. B. (2026). Multifold increase in spinal inhibitory
    cell types with emergence of limb movement. <i>Cell Reports</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.celrep.2026.117227">https://doi.org/10.1016/j.celrep.2026.117227</a>
  chicago: Vijatovic, David, Florina Alexandra  Toma, Y Ignatyev, Zoe P Harrington,
    Christoph M Sommer, Robert Hauschild, Matthijs Geert Smits, et al. “Multifold
    Increase in Spinal Inhibitory Cell Types with Emergence of Limb Movement.” <i>Cell
    Reports</i>. Elsevier, 2026. <a href="https://doi.org/10.1016/j.celrep.2026.117227">https://doi.org/10.1016/j.celrep.2026.117227</a>.
  ieee: D. Vijatovic <i>et al.</i>, “Multifold increase in spinal inhibitory cell
    types with emergence of limb movement,” <i>Cell Reports</i>, vol. 45, no. 4. Elsevier,
    2026.
  ista: Vijatovic D, Toma FA, Ignatyev Y, Harrington ZP, Sommer CM, Hauschild R, Smits
    MG, Dalla Vecchia M, Trevisan AJ, Chapman P, Julseth M, Brenner-Morton S, Gabitto
    MI, Dasen JS, Bikoff JB, Sweeney LB. 2026. Multifold increase in spinal inhibitory
    cell types with emergence of limb movement. Cell Reports. 45(4), 117227.
  mla: Vijatovic, David, et al. “Multifold Increase in Spinal Inhibitory Cell Types
    with Emergence of Limb Movement.” <i>Cell Reports</i>, vol. 45, no. 4, 117227,
    Elsevier, 2026, doi:<a href="https://doi.org/10.1016/j.celrep.2026.117227">10.1016/j.celrep.2026.117227</a>.
  short: D. Vijatovic, F.A. Toma, Y. Ignatyev, Z.P. Harrington, C.M. Sommer, R. Hauschild,
    M.G. Smits, M. Dalla Vecchia, A.J. Trevisan, P. Chapman, M. Julseth, S. Brenner-Morton,
    M.I. Gabitto, J.S. Dasen, J.B. Bikoff, L.B. Sweeney, Cell Reports 45 (2026).
corr_author: '1'
date_created: 2026-04-19T22:07:43Z
date_published: 2026-04-28T00:00:00Z
date_updated: 2026-08-20T14:45:18Z
day: '28'
ddc:
- '570'
department:
- _id: LoSw
- _id: GradSch
- _id: TiVo
- _id: Bio
- _id: NiBa
doi: 10.1016/j.celrep.2026.117227
external_id:
  pmid:
  - '41964955 '
file:
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has_accepted_license: '1'
intvolume: '        45'
issue: '4'
language:
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month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: ebb66355-77a9-11ec-83b8-b8ac210a4dae
  grant_number: '101041551'
  name: Development and Evolution of Tetrapod Motor Circuits
- _id: 8da85f50-16d5-11f0-9cad-eab8b0ff6c9e
  grant_number: F7814
  name: 'Stem Cell Modulation in Neural Development and Regeneration/ P14-Swim-to-limb
    transition: cell type to connection diversity'
- _id: c08e9ad1-5a5b-11eb-8a69-9d1cf3b07473
  grant_number: CZI01
  name: Tools for automation and feedback microscopy
- _id: bd73af52-d553-11ed-ba76-912049f0ac7a
  grant_number: FTI21-D-046
  name: Development of V1 interneuron diversity during swim-to-walk transition of
    Xenopus metamorphosis
publication: Cell Reports
publication_identifier:
  eissn:
  - 2211-1247
  issn:
  - 2639-1856
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
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    status: public
scopus_import: '1'
status: public
title: Multifold increase in spinal inhibitory cell types with emergence of limb movement
tmp:
  image: /images/cc_by.png
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  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 45
year: '2026'
...
---
OA_place: publisher
_id: '22664'
abstract:
- lang: eng
  text: "The widespread adoption of apps like Whatsapp and Signal has translated into
    billions of people all around the world communicating on a regular basis by making
    use of services that offer end-to-end encryption and even provide security guarantees
    when a user's device is compromised.\r\n\r\nThis was made possible by the introduction
    of the Double Ratchet Algorithm~\\cite{double_ratchet}, which was designed for
    a setting where communication takes place between two parties.\r\nHowever, in
    practice, many apps offer the possibility of creating groups.\r\nThe protocols
    they use to secure communication are inefficient for large group which has the
    undesireable consequence that the aforementioned apps have established limits
    on the group size of roughly 1000 users.\r\nThis has motivated the introduction
    of the Messaging Layer Security (MLS) standard~\\cite{rfc9420} by the IETF which
    is based on a primitive called Continuous Group Key Agreement (CGKA)~\\cite{C:ACDT20}.\r\n\r\nThis
    primitive allows a group of users to maintain a shared secret key that is frequently
    rotated by the group members in order to change group membership, achieve forward
    secrecy (FS) and post compromise security (PCS).\r\nMost protocols are based on
    binary trees where the nodes are associated to a pair formed by public key and
    a secret key.\r\nEach leaf corresponds to one of the group members and a user
    knows the secret keys associated to nodes along the path from their leaf to the
    root.\r\nWhen a user wants to update their key material they have to change $
    \\log(N) $ many keys.\r\nThis requires uploading $ \\log(N) $ many ciphertexts
    to communicate the new keys to the rest of the group members in a way that respects
    the tree structure.\r\n\r\nIn this thesis we study how much communication between
    group members is required in order to add and remove users from a group as well
    as in order to provide PCS when we consider CGKAs built using standard cryptographic
    primitives like pseudo-random functions and public-key encryption. Furthermore,
    we also consider the case of MLS and provide the first lower bound showing that
    its communication complexity is much worse than previously believed, i.e., it
    is very far from $ \\log(N) $.\r\nFinally, we also propose a variant of MLS which
    provably achieves the same security properties with a much lower communication
    cost."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Miguel
  full_name: Cueto Noval, Miguel
  id: ffc563a3-f6e0-11ea-865d-e3cce03d17cc
  last_name: Cueto Noval
  orcid: 0000-0002-2505-4246
citation:
  ama: Cueto Noval M. Towards efficient secure group messaging. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22664">10.15479/AT-ISTA-22664</a>
  apa: Cueto Noval, M. (2026). <i>Towards efficient secure group messaging</i>. Institute
    of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22664">https://doi.org/10.15479/AT-ISTA-22664</a>
  chicago: Cueto Noval, Miguel. “Towards Efficient Secure Group Messaging.” Institute
    of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22664">https://doi.org/10.15479/AT-ISTA-22664</a>.
  ieee: M. Cueto Noval, “Towards efficient secure group messaging,” Institute of Science
    and Technology Austria, 2026.
  ista: Cueto Noval M. 2026. Towards efficient secure group messaging. Institute of
    Science and Technology Austria.
  mla: Cueto Noval, Miguel. <i>Towards Efficient Secure Group Messaging</i>. Institute
    of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22664">10.15479/AT-ISTA-22664</a>.
  short: M. Cueto Noval, Towards Efficient Secure Group Messaging, Institute of Science
    and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-08-10T10:18:35Z
date_published: 2026-08-10T00:00:00Z
date_updated: 2026-08-21T10:53:17Z
day: '10'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: GradSch
- _id: KrPi
doi: 10.15479/AT-ISTA-22664
doi_confirm: '1'
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  file_id: '22702'
  file_name: 2026_CuetoNoval_Miguel_Thesis.pdf
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  checksum: 4d6def422cc93a108faf5e5defc0f807
  content_type: application/zip
  creator: mcuetono
  date_created: 2026-08-13T09:39:01Z
  date_updated: 2026-08-14T10:26:06Z
  file_id: '22703'
  file_name: 2026_CuetoNoval_Miguel_Thesis.zip
  file_size: 9923509
  relation: source_file
file_date_updated: 2026-08-19T11:36:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '187'
publication_identifier:
  isbn:
  - ' 978-3-99078-087-9'
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
  record:
  - id: '14691'
    relation: part_of_dissertation
    status: public
  - id: '18702'
    relation: part_of_dissertation
    status: public
  - id: '21262'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
title: Towards efficient secure group messaging
tmp:
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    BY-NC-SA 4.0)
  short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: publisher
_id: '22694'
abstract:
- lang: eng
  text: "We develop and employ techniques from equivariant algebraic K-theory and
    related invariants\r\nin the context of geometric representation theory, in both
    arithmetic and topological situations.\r\nWe showcase the use of such techniques
    on the affine Grassmannian Gr, a space of fundamental\r\ninterest in the geometric
    Langlands program.\r\n\r\nIt is a deep development of mathematics of the last
    century that many concrete, yet combina-\r\ntorially complex algebraic problems
    may be effectively studied through the lens of algebraic\r\ngeometry. The objects
    of interest can be often realized as cohomological invariants of algebraic\r\nvarieties,
    and good understanding of their geometry sheds light into the original questions.\r\nSuch
    techniques have seen immense applications in the Langlands program, where they
    go\r\nunder the label of geometric representation theory.\r\n\r\nOne source of
    powerful invariants in algebraic geometry comes from algebraic K-theory,\r\nHochschild
    homology, and their relatives. These localizing invariants contain large amount\r\nof
    information, but are quite hard to compute. For this reason, their usage in geometric\r\nrepresentation
    theory has been limited.\r\n\r\nThe aim of this thesis is to showcase how to control
    such invariants in the situations of\r\ninterest and use them to obtain new insights.
    We start by reinterpreting equivariant Hochschild\r\nhomology in terms of functions
    on certain fixed-point schemes, which are of independent\r\ninterest. We compare
    it to equivariant K-theory via the trace map. We give new computations\r\nand
    comparisons of such invariants of affine Schubert varieties in Gr, including arithmetic\r\nsituations.
    We show that they behave much better than expected.\r\n\r\nWe finally utilize
    this circle of ideas in a purely topological setting. We describe the varying\r\nfixed
    points of the extended torus action on the affine Grassmannian, and use it to
    compute\r\nits equivariant topological K-theory ring. The answer is nontrivial
    and verifies an outstanding\r\nconjecture in the subject.\r\n\r\nWe compare, partly
    conjecturally, the resulting K-theory ring to the completed center of an\r\nintegral
    even hybrid quantum group and its deformed quantum category O. This gives a\r\ngenuine
    application of our computations in pure representation theory."
acknowledgement: "It was funded by a DOC Fellowship of the Austrian Academy of Sciences
  entitled Arithmetic,\r\ngeometry, topology and representation theory arising from
  the affine Grassmannian. It was\r\nfurther funded by the Austrian Science Fund FWF
  10.55776/P35847, and an Erasmus+ staff\r\nmobility training. \r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Jakub
  full_name: Löwit, Jakub
  id: e3b80ae2-eb8e-11eb-b029-9aef4a9108a0
  last_name: Löwit
citation:
  ama: Löwit J. Equivariant K-theory of affine Grassmannians in representation theory
    and arithmetic. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22694">10.15479/AT-ISTA-22694</a>
  apa: Löwit, J. (2026). <i>Equivariant K-theory of affine Grassmannians in representation
    theory and arithmetic</i>. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22694">https://doi.org/10.15479/AT-ISTA-22694</a>
  chicago: Löwit, Jakub. “Equivariant K-Theory of Affine Grassmannians in Representation
    Theory and Arithmetic.” Institute of Science and Technology Austria, 2026. <a
    href="https://doi.org/10.15479/AT-ISTA-22694">https://doi.org/10.15479/AT-ISTA-22694</a>.
  ieee: J. Löwit, “Equivariant K-theory of affine Grassmannians in representation
    theory and arithmetic,” Institute of Science and Technology Austria, 2026.
  ista: Löwit J. 2026. Equivariant K-theory of affine Grassmannians in representation
    theory and arithmetic. Institute of Science and Technology Austria.
  mla: Löwit, Jakub. <i>Equivariant K-Theory of Affine Grassmannians in Representation
    Theory and Arithmetic</i>. Institute of Science and Technology Austria, 2026,
    doi:<a href="https://doi.org/10.15479/AT-ISTA-22694">10.15479/AT-ISTA-22694</a>.
  short: J. Löwit, Equivariant K-Theory of Affine Grassmannians in Representation
    Theory and Arithmetic, Institute of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-08-12T14:05:36Z
date_published: 2026-08-05T00:00:00Z
date_updated: 2026-08-26T06:53:55Z
day: '05'
ddc:
- '510'
- '516'
- '512'
- '514'
- '513'
degree_awarded: PhD
department:
- _id: GradSch
- _id: TaHa
doi: 10.15479/AT-ISTA-22694
doi_confirm: '1'
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  date_updated: 2026-08-14T11:42:42Z
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  file_name: 2026_Löwit_Jakub_Source_files.zip
  file_size: 1085118
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file_date_updated: 2026-08-14T11:42:42Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '185'
project:
- _id: 901e2a43-16d5-11f0-9cad-9cead34748d6
  grant_number: '27004'
  name: Arithmetic, geometry, topology and representation theory arising from the
    affine Grassmannian
- _id: 34b2c9cb-11ca-11ed-8bc3-a50ba74ca4a3
  grant_number: P35847
  name: Geometry of the tip of the global nilpotent cone
publication_identifier:
  issn:
  - 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
publisher_comment: "For open access purposes, the author has applied a CC BY public
  copyright\r\nlicense to any author-accepted manuscript version arising from this
  submission."
related_material:
  record:
  - id: '21751'
    relation: part_of_dissertation
    status: public
  - id: '22693'
    relation: part_of_dissertation
    status: public
status: public
supervisor:
- first_name: Tamás
  full_name: Hausel, Tamás
  id: 4A0666D8-F248-11E8-B48F-1D18A9856A87
  last_name: Hausel
  orcid: 0000-0002-9582-2634
title: Equivariant K-theory of affine Grassmannians in representation theory and arithmetic
tmp:
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  short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21751'
abstract:
- lang: eng
  text: 'We define a certain class of simple varieties over a field k by a constructive
    recipe and show how to control their (equivariant) truncating invariants. Consequently,
    we prove that on simple varieties: (i) if k = k and char k = p, the p-adic cyclotomic
    trace is an equivalence; (ii) if k = Q, the Goodwillie–Jones trace is an isomorphism
    in degree zero; (iii) we can control homotopy invariant K-theory KH, which is
    equivariantly formal and determined by its topological counterparts. Simple varieties
    are quite special, but encompass important singular examples appearing in geometric
    representation theory. We, in particular, show that both finite and affine Schubert
    varieties for GLn lie in this class, so all the above results hold for them. '
acknowledgement: "This work was supported by a DOC Fellowship of the Austrian Academy
  of Sciences at the Institute of Science and Technology Austria (ISTA) and by an
  Erasmus+ staff mobility training. It took place during the author’s visit to Laboratoire
  de Mathématiques d’Orsay in the course of his PhD at the Institute of Science and
  Technology Austria. First and foremost, I would like to thank Matthew Morrow for
  discussions, explanations and ideas without which this work would not have been
  carried out. I would further like to thank Brian Conrad for providing an amazing
  reference on projective cones in appropriate generality, to Vova Sosnilo for carefully
  discussing – among other things – the derived nilinvariance for quotients by any
  linearly reductive group, and to Adeel Khan, Timo Richarz, Matthias Wendt and Xinwen
  Zhu for helpful conversations\r\nabout the results. I would moreover like to thank
  the referee for the very useful comments."
article_number: rnag058
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Jakub
  full_name: Löwit, Jakub
  id: e3b80ae2-eb8e-11eb-b029-9aef4a9108a0
  last_name: Löwit
citation:
  ama: Löwit J. Equivariant localizing invariants of simple varieties. <i>International
    Mathematics Research Notices</i>. 2026;2026(7). doi:<a href="https://doi.org/10.1093/imrn/rnag058">10.1093/imrn/rnag058</a>
  apa: Löwit, J. (2026). Equivariant localizing invariants of simple varieties. <i>International
    Mathematics Research Notices</i>. Oxford University Press. <a href="https://doi.org/10.1093/imrn/rnag058">https://doi.org/10.1093/imrn/rnag058</a>
  chicago: Löwit, Jakub. “Equivariant Localizing Invariants of Simple Varieties.”
    <i>International Mathematics Research Notices</i>. Oxford University Press, 2026.
    <a href="https://doi.org/10.1093/imrn/rnag058">https://doi.org/10.1093/imrn/rnag058</a>.
  ieee: J. Löwit, “Equivariant localizing invariants of simple varieties,” <i>International
    Mathematics Research Notices</i>, vol. 2026, no. 7. Oxford University Press, 2026.
  ista: Löwit J. 2026. Equivariant localizing invariants of simple varieties. International
    Mathematics Research Notices. 2026(7), rnag058.
  mla: Löwit, Jakub. “Equivariant Localizing Invariants of Simple Varieties.” <i>International
    Mathematics Research Notices</i>, vol. 2026, no. 7, rnag058, Oxford University
    Press, 2026, doi:<a href="https://doi.org/10.1093/imrn/rnag058">10.1093/imrn/rnag058</a>.
  short: J. Löwit, International Mathematics Research Notices 2026 (2026).
corr_author: '1'
date_created: 2026-04-19T22:07:48Z
date_published: 2026-04-01T00:00:00Z
date_updated: 2026-08-26T06:53:54Z
day: '01'
ddc:
- '510'
department:
- _id: TaHa
doi: 10.1093/imrn/rnag058
external_id:
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abstract:
- lang: eng
  text: We study torus-equivariant algebraic K-theory of affine Schubert varieties
    in the perfect affine Grassmannians over Fp. We further compare it to the torus-equivariant
    Hochschild homology of perfect complexes, which has a geometric description in
    terms of global functions on certain fixed-point schemes. We prove that Fp-linearly,
    this comparison is an isomorphism. Our approach is quite constructive, resulting
    in new computations of these K-theory rings. We establish various structural results
    for equivariant perfect algebraic K-theory on the way; we believe these are of
    independent interest.
acknowledgement: "I would like to thank the following people for fruitful discussions,\r\nhelpful
  sanity checks or comments on previous drafts: Roman Bezrukavnikov, Jens Niklas Eberhardt,
  Mischa Elkner, Tamás Hausel, Andres Fernandez Herrero, Adeel Khan,\r\nBernhard Köck,
  Andrei Konovalov, Quoc Ho, Mirko Mauri, Matthew Morrow, Charanya\r\nRavi, Kamil
  Rychlewicz, Shyiu Shen, Vladimir Sosnilo, Georg Tamme, Xinwen Zhu. I\r\nwould further
  like to thank Marc Hoyois and the anonymous referee for spotting an error\r\nin
  a previous version.\r\nThis work was done during author’s PhD at the Institute of
  Science and Technology Austria (ISTA). It was funded by a DOC Fellowship of the
  Austrian Academy\r\nof Sciences and by the Austrian Science Fund (FWF) 10.55776/P35847.
  For open access\r\npurposes, the author has applied a CC BY public copyright license
  to any author-accepted\r\nmanuscript version arising from this submission."
article_processing_charge: Yes (in subscription journal)
article_type: original
arxiv: 1
author:
- first_name: Jakub
  full_name: Löwit, Jakub
  id: e3b80ae2-eb8e-11eb-b029-9aef4a9108a0
  last_name: Löwit
citation:
  ama: Löwit J. Equivariant K-theory, affine Grassmannian and perfection. <i>Documenta
    Mathematica</i>. 2026. doi:<a href="https://doi.org/10.4171/dm/1064">10.4171/dm/1064</a>
  apa: Löwit, J. (2026). Equivariant K-theory, affine Grassmannian and perfection.
    <i>Documenta Mathematica</i>. EMS Press. <a href="https://doi.org/10.4171/dm/1064">https://doi.org/10.4171/dm/1064</a>
  chicago: Löwit, Jakub. “Equivariant K-Theory, Affine Grassmannian and Perfection.”
    <i>Documenta Mathematica</i>. EMS Press, 2026. <a href="https://doi.org/10.4171/dm/1064">https://doi.org/10.4171/dm/1064</a>.
  ieee: J. Löwit, “Equivariant K-theory, affine Grassmannian and perfection,” <i>Documenta
    Mathematica</i>. EMS Press, 2026.
  ista: Löwit J. 2026. Equivariant K-theory, affine Grassmannian and perfection. Documenta
    Mathematica.
  mla: Löwit, Jakub. “Equivariant K-Theory, Affine Grassmannian and Perfection.” <i>Documenta
    Mathematica</i>, EMS Press, 2026, doi:<a href="https://doi.org/10.4171/dm/1064">10.4171/dm/1064</a>.
  short: J. Löwit, Documenta Mathematica (2026).
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-12T13:29:17Z
date_published: 2026-03-26T00:00:00Z
date_updated: 2026-08-26T06:53:54Z
day: '26'
ddc:
- '500'
department:
- _id: GradSch
- _id: TaHa
doi: 10.4171/dm/1064
external_id:
  arxiv:
  - '2409.18925'
has_accepted_license: '1'
keyword:
- equivariant algebraic K-theory
- perfection in positive characteristic
- affine Grassmannian
- affine Schubert varieties
- Dennis trace map
- equivariant Hochschild homology
- fixed-point schemes
- toric varieties
language:
- iso: eng
main_file_link:
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  url: https://doi.org/10.4171/DM/1064
mathsc:
- '19E08'
- 19L47
- 20G44
- 14G17
- 19D55
- 14F43
- 14L30
- 14D24
- 14M25
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 34b2c9cb-11ca-11ed-8bc3-a50ba74ca4a3
  grant_number: P35847
  name: Geometry of the tip of the global nilpotent cone
publication: Documenta Mathematica
publication_identifier:
  eissn:
  - 1431-0643
  issn:
  - 1431-0635
publication_status: epub_ahead
publisher: EMS Press
quality_controlled: '1'
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title: Equivariant K-theory, affine Grassmannian and perfection
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_id: '22684'
abstract:
- lang: eng
  text: "Contact electrification (CE) is a simple yet elusive phenomenon that occurs
    when two materials come into contact and separate, leaving behind net electrical
    charge. Despite its ubiquity, the microscopic origin of CE remains unclear. In
    this thesis, we investigate CE from three complementary perspectives: developing
    a quantitative method to measure charge at the nanoscale, exploring the dynamic
    behavior of charge on insulating surfaces, and uncovering the role of mechanical
    history in forming a triboelectric series.\r\n\r\nIn the first part, we establish
    a rigorous framework for converting qualitative Kelvin probe force microscopy
    (KPFM) voltage maps into quantitative charge density distributions. Using finite
    element method (FEM) simulations, we determine the point-spread function of the
    KPFM tip–sample geometry and demonstrate that the true surface charge can be reconstructed
    by numerical deconvolution. This procedure enables the recovery of both the magnitude
    and sign of charge density with high fidelity, resolving nanoscale features that
    are otherwise obscured. Applying the method to contact-charged SiO$_2$ surfaces,
    we show that existing analytical approximations, such as parallel plate or spherical
    models, can miscalculate charge magnitude by orders of magnitude. Our hybrid FEM/KPFM
    approach therefore provides a fast and general method to convert qualitative KPFM
    signals into quantitative charge data, enabling nanoscale charge mapping under
    realistic experimental conditions.\r\n\r\nIn the second part, we study the temporal
    stability of CE-induced charges and identify the key material factors that determine
    whether KPFM can capture meaningful charge patterns. Through time-resolved experiments
    combining a custom-built transfer system with both microscopic and macroscopic
    measurements, we demonstrate that only the best insulators, such as SiO$_2$, preserve
    CE charge long enough for stationary imaging. For less conductive polymers, such
    as PDMS, charge decays within the duration of a single KPFM scan due to bulk conduction.
    Using a simple capacitor-based model, we reproduce the observed decay dynamics
    and confirm that the transferred charge decays characteristic to the sample's
    bulk conductivity. Further, we always observe homogeneous charge transfer.\r\n\r\nIn
    the third part, we address the question: can we form a triboelectric series with
    identical materials? Using controlled repetitive contact experiments, we show
    that nominally identical materials can progressively order themselves into a triboelectric
    series, where surfaces with more contact history charge negatively relative to
    fresher ones. By constructing a minimal model based on this ``contact bias'',
    we replicate the evolution from random to ordered charging observed in experiments.
    Supporting surface analyses, including atomic force microscopy, reveal that repeated
    contact induces nanoscale morphological changes, suggesting a mechanism tightly
    coupled to mechanical strain. These results highlight the crucial role of surface
    history and nanoscale mechanics in dictating charge transfer, motivating further
    exploration of mechanisms such as mechanochemical bond cleavage and flexoelectric
    polarization."
acknowledged_ssus:
- _id: NanoFab
- _id: ScienComp
- _id: LifeSc
- _id: M-Shop
- _id: EM-Fac
acknowledgement: "This project has received financing from the European Research Council
  grant agreement\r\nno. 949120 under the European Union’s Horizon 2020 research and
  innovation programme.\r\nThis research was supported by the Scientific Service Units
  of The Institute of Science\r\nand Technology Austria (ISTA) through resources provided
  by the Miba Machine Shop, the\r\nNanofabrication Facility, the Lab Support Facility,
  the Scientific Computing Facility and the\r\nElectron Microscopy Facility. We thank
  Florian Stumpf from Park Systems for useful discussions\r\nand support with scanning
  probe microscopy. We thank Joaquin Garcia-Suarez and Guillaume\r\nAnciaux for the
  suggestion to look into the roughness power spectral density. We thank\r\nIrina-Malina
  Strugaru for help with testing the device for Young’s modulus measurements.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Felix
  full_name: Pertl, Felix
  id: 6313aec0-15b2-11ec-abd3-ed67d16139af
  last_name: Pertl
  orcid: 0000-0003-0463-5794
citation:
  ama: Pertl F. Experimental probing of nanoscale charge features and surface morphology
    changes during tribocharging. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22684">10.15479/AT-ISTA-22684</a>
  apa: Pertl, F. (2026). <i>Experimental probing of nanoscale charge features and
    surface morphology changes during tribocharging</i>. Institute of Science and
    Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22684">https://doi.org/10.15479/AT-ISTA-22684</a>
  chicago: Pertl, Felix. “Experimental Probing of Nanoscale Charge Features and Surface
    Morphology Changes during Tribocharging.” Institute of Science and Technology
    Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22684">https://doi.org/10.15479/AT-ISTA-22684</a>.
  ieee: F. Pertl, “Experimental probing of nanoscale charge features and surface morphology
    changes during tribocharging,” Institute of Science and Technology Austria, 2026.
  ista: Pertl F. 2026. Experimental probing of nanoscale charge features and surface
    morphology changes during tribocharging. Institute of Science and Technology Austria.
  mla: Pertl, Felix. <i>Experimental Probing of Nanoscale Charge Features and Surface
    Morphology Changes during Tribocharging</i>. Institute of Science and Technology
    Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22684">10.15479/AT-ISTA-22684</a>.
  short: F. Pertl, Experimental Probing of Nanoscale Charge Features and Surface Morphology
    Changes during Tribocharging, Institute of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-08-12T09:44:40Z
date_published: 2026-08-12T00:00:00Z
date_updated: 2026-08-27T11:42:44Z
day: '12'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: ScWa
doi: 10.15479/AT-ISTA-22684
doi_confirm: '1'
ec_funded: 1
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language:
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oa_version: Published Version
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project:
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  call_identifier: H2020
  grant_number: '949120'
  name: 'Tribocharge: a multi-scale approach to an enduring problem in physics'
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  issn:
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publisher: Institute of Science and Technology Austria
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supervisor:
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  full_name: Waitukaitis, Scott R
  id: 3A1FFC16-F248-11E8-B48F-1D18A9856A87
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  orcid: 0000-0002-2299-3176
title: Experimental probing of nanoscale charge features and surface morphology changes
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acknowledgement: "This research was supported by the Scientific Service Units of Institute
  of Science and\r\nTechnology Austria through resources provided by the Lab Support
  Facility and Electron\r\nMicroscopy Facility at ISTA. Monoclonal Antibody Facility
  at Max Perutz laboratories are\r\nacknowledged for raising anti-pSer1022 MDA5 antibody.
  Proteomics core facility CEITEC MUNI\r\nBrno, namely David Pospíšil, are acknowledged
  for their help with measuring MS data as well\r\nas help with interpreting them
  and the introduction into MS data analysis. CIISB, Instruct-CZ\r\nCentre of Instruct-ERIC
  EU consortium, funded by MEYS CR infrastructure project LM2023042,\r\nis gratefully
  acknowledged for the financial support of the measurements at the CEITEC\r\nProteomics
  Core Facility. Computational resources were provided by the e-INFRA CZ project\r\n(ID:90254),
  supported by MEYS CR.\r\nThis work was supported by the Austrian Science Fund (FWF)
  grant F8003-B RNA-DECO:\r\nDecorating RNA for a purpose (10.55776/F80)."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: David
  full_name: Michalik, David
  id: B9577E20-AA38-11E9-AC9A-0930E6697425
  last_name: Michalik
citation:
  ama: Michalik D. Mechanistic insights into MDA5 selectivity and regulation. 2026.
    doi:<a href="https://doi.org/10.15479/AT-ISTA-22745">10.15479/AT-ISTA-22745</a>
  apa: Michalik, D. (2026). <i>Mechanistic insights into MDA5 selectivity and regulation</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22745">https://doi.org/10.15479/AT-ISTA-22745</a>
  chicago: Michalik, David. “Mechanistic Insights into MDA5 Selectivity and Regulation.”
    Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22745">https://doi.org/10.15479/AT-ISTA-22745</a>.
  ieee: D. Michalik, “Mechanistic insights into MDA5 selectivity and regulation,”
    Institute of Science and Technology Austria, 2026.
  ista: Michalik D. 2026. Mechanistic insights into MDA5 selectivity and regulation.
    Institute of Science and Technology Austria.
  mla: Michalik, David. <i>Mechanistic Insights into MDA5 Selectivity and Regulation</i>.
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22745">10.15479/AT-ISTA-22745</a>.
  short: D. Michalik, Mechanistic Insights into MDA5 Selectivity and Regulation, Institute
    of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-08-21T09:29:34Z
date_published: 2026-08-21T00:00:00Z
date_updated: 2026-08-28T08:34:46Z
day: '21'
ddc:
- '572'
degree_awarded: PhD
department:
- _id: CaBe
- _id: GradSch
doi: 10.15479/AT-ISTA-22745
doi_confirm: '1'
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publication_identifier:
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  - 2663-337X
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publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Carrie A
  full_name: Bernecky, Carrie A
  id: 2CB9DFE2-F248-11E8-B48F-1D18A9856A87
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acknowledged_ssus:
- _id: M-Shop
- _id: PreCl
- _id: Bio
acknowledgement: "This project was supported by the following funding agencies: ERC
  under the European\r\nUnion's Horizon 2020 research and innovation program (ERC
  Advanced Grants No 692692\r\n“GIANTSYN” and 101199096 “CA3-SYNGRAM” to P.J.), the
  Fonds zur Förderung der\r\nwissenschaftlichen Forschung (P 36232-B, stand-alone
  grant, PAT 4178023, principal\r\ninvestigator project, and 10.55776/CoE 16 “GABA
  neurons” to P.J.), and the European Union’s\r\nHorizon 2020 research and innovation
  programme under the Marie Skłodowska-Curie grant\r\nagreement (No 101034413, to
  K.L.)."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Peipeng
  full_name: Lin, Peipeng
  id: 7E3060D0-A92C-11E9-A326-26C8E5697425
  last_name: Lin
citation:
  ama: 'Lin P. Calibrating the teacher synapse: Mechanisms and functional significance
    of presynaptic inhibition at hippocampal mossy fiber synapses. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22735">10.15479/AT-ISTA-22735</a>'
  apa: 'Lin, P. (2026). <i>Calibrating the teacher synapse: Mechanisms and functional
    significance of presynaptic inhibition at hippocampal mossy fiber synapses</i>.
    Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22735">https://doi.org/10.15479/AT-ISTA-22735</a>'
  chicago: 'Lin, Peipeng. “Calibrating the Teacher Synapse: Mechanisms and Functional
    Significance of Presynaptic Inhibition at Hippocampal Mossy Fiber Synapses.” Institute
    of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22735">https://doi.org/10.15479/AT-ISTA-22735</a>.'
  ieee: 'P. Lin, “Calibrating the teacher synapse: Mechanisms and functional significance
    of presynaptic inhibition at hippocampal mossy fiber synapses,” Institute of Science
    and Technology Austria, 2026.'
  ista: 'Lin P. 2026. Calibrating the teacher synapse: Mechanisms and functional significance
    of presynaptic inhibition at hippocampal mossy fiber synapses. Institute of Science
    and Technology Austria.'
  mla: 'Lin, Peipeng. <i>Calibrating the Teacher Synapse: Mechanisms and Functional
    Significance of Presynaptic Inhibition at Hippocampal Mossy Fiber Synapses</i>.
    Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22735">10.15479/AT-ISTA-22735</a>.'
  short: 'P. Lin, Calibrating the Teacher Synapse: Mechanisms and Functional Significance
    of Presynaptic Inhibition at Hippocampal Mossy Fiber Synapses, Institute of Science
    and Technology Austria, 2026.'
corr_author: '1'
das_tickbox: '0'
date_created: 2026-08-18T15:23:41Z
date_published: 2026-08-25T00:00:00Z
date_updated: 2026-08-31T11:11:55Z
day: '25'
ddc:
- '571'
- '573'
degree_awarded: PhD
department:
- _id: GradSch
- _id: PeJo
doi: 10.15479/AT-ISTA-22735
doi_confirm: '1'
ec_funded: 1
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language:
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month: '08'
oa_version: Published Version
page: '88'
project:
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  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
- _id: e62b56fe-ab3c-11f0-94c7-d181dd352b3b
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  name: Mechanisms of GABA release in hippocampal circuits
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publication_identifier:
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  issn:
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publication_status: published
publisher: Institute of Science and Technology Austria
researchdata_availability: upon request
status: public
supervisor:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
supplementarymaterial: yes
title: 'Calibrating the teacher synapse: Mechanisms and functional significance of
  presynaptic inhibition at hippocampal mossy fiber synapses'
tmp:
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    (CC BY-NC-ND 4.0)
  short: CC BY-NC-ND (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_type: closed access
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abstract:
- lang: eng
  text: Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular
    organization. The plasmid-encoded ParMRC system forms actin-like filaments that
    segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena
    sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal
    system named CorMR with a function in cell shape control rather than DNA segregation.
    Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed
    that CorM formed dynamically unstable, antiparallel double-stranded filaments
    that were recruited to the membrane by CorR through an amphipathic helix conserved
    in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which
    excluded them from the poles and division plane. Comparative genomics indicated
    that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity,
    highlighting the evolutionary plasticity of cytoskeletal systems in bacteria.
acknowledged_ssus:
- _id: Bio
- _id: ScienComp
- _id: EM-Fac
- _id: LifeSc
acknowledgement: "We thank all members of the Loose lab at ISTA for helpful discussions;
  M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University)
  for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial
  strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial
  strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing
  the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix
  screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data
  collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work
  was supported by the Scientific Service Units (SSU) of ISTA through resources provided
  by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the
  Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work
  was funded by the European Union’s Horizon 2020 research and innovation program
  (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council
  (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National
  Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques
  et Letitia Lopez-Loreta Foundation (G.L.W.)."
article_number: eaea6343
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin L
  full_name: Springstein, Benjamin L
  id: b4eb62ef-ac72-11ed-9503-ed3b4d66c083
  last_name: Springstein
  orcid: 0000-0002-3461-5391
- first_name: Manjunath
  full_name: Javoor, Manjunath
  id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
  last_name: Javoor
  orcid: 0000-0003-2311-2112
- first_name: Daniela
  full_name: Megrian, Daniela
  last_name: Megrian
- first_name: Roman
  full_name: Hajdu, Roman
  id: ffab949d-133f-11ed-8f02-94de21ace503
  last_name: Hajdu
- first_name: Dustin M.
  full_name: Hanke, Dustin M.
  last_name: Hanke
- first_name: Bettina
  full_name: Zens, Bettina
  id: 45FD126C-F248-11E8-B48F-1D18A9856A87
  last_name: Zens
  orcid: 0000-0002-9561-1239
- first_name: Gregor L.
  full_name: Weiss, Gregor L.
  last_name: Weiss
- first_name: Florian Km
  full_name: Schur, Florian Km
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
  last_name: Schur
  orcid: 0000-0003-4790-8078
- first_name: Martin
  full_name: Loose, Martin
  id: 462D4284-F248-11E8-B48F-1D18A9856A87
  last_name: Loose
  orcid: 0000-0001-7309-9724
citation:
  ama: Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation
    machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. 2026;392(6795).
    doi:<a href="https://doi.org/10.1126/science.aea6343">10.1126/science.aea6343</a>
  apa: Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens,
    B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal
    system controlling cell shape. <i>Science</i>. AAAS. <a href="https://doi.org/10.1126/science.aea6343">https://doi.org/10.1126/science.aea6343</a>
  chicago: Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu,
    Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose.
    “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling
    Cell Shape.” <i>Science</i>. AAAS, 2026. <a href="https://doi.org/10.1126/science.aea6343">https://doi.org/10.1126/science.aea6343</a>.
  ieee: B. L. Springstein <i>et al.</i>, “Repurposing of a DNA segregation machinery
    into a cytoskeletal system controlling cell shape,” <i>Science</i>, vol. 392,
    no. 6795. AAAS, 2026.
  ista: Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL,
    Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal
    system controlling cell shape. Science. 392(6795), eaea6343.
  mla: Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery
    into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>, vol. 392,
    no. 6795, eaea6343, AAAS, 2026, doi:<a href="https://doi.org/10.1126/science.aea6343">10.1126/science.aea6343</a>.
  short: B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L.
    Weiss, F.K. Schur, M. Loose, Science 392 (2026).
corr_author: '1'
date_created: 2026-04-26T22:01:46Z
date_published: 2026-04-16T00:00:00Z
date_updated: 2026-09-03T09:36:24Z
day: '16'
department:
- _id: MaLo
- _id: FlSc
- _id: GradSch
- _id: EM-Fac
doi: 10.1126/science.aea6343
ec_funded: 1
external_id:
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intvolume: '       392'
issue: '6795'
language:
- iso: eng
month: '04'
oa_version: None
pmid: 1
project:
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  grant_number: '101034413'
  name: 'IST-BRIDGE: International postdoctoral program'
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  grant_number: '101076260'
  name: A molecular atlas of Actin filament IDentities in the cell motility machinery
publication: Science
publication_identifier:
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  issn:
  - 0036-8075
publication_status: published
publisher: AAAS
quality_controlled: '1'
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scopus_import: '1'
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title: Repurposing of a DNA segregation machinery into a cytoskeletal system controlling
  cell shape
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 392
year: '2026'
...
---
OA_embargo: '12'
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acknowledged_ssus:
- _id: Bio
- _id: EM-Fac
- _id: ScienComp
- _id: LifeSc
acknowledgement: "This work was supported by the ERC StG grant ActinID (PRA01221F1049A)
  awarded to Florian\r\nSchur, the ERC-SyG grant Pushing from within (P01071793) awarded
  to Michael Sixt, and by ISTA.\r\nI would like to thank the Scientific Service Units
  at ISTA for their essential support throughout\r\nthis work. In particular, I am
  grateful to the Electron Microscopy Facility, Imaging and Optics\r\nFacility, Zebrafish
  Facility, Scientific Computing Facility, and Lab Support Facility for their services,\r\nand
  technical support, all of which were important for the successful completion of
  this project."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Manjunath
  full_name: Javoor, Manjunath
  id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2
  last_name: Javoor
  orcid: 0000-0003-2311-2112
citation:
  ama: Javoor M. Large-scale imaging of cellular actin networks at single filament
    resolution using montage cryo-electron tomography. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22744">10.15479/AT-ISTA-22744</a>
  apa: Javoor, M. (2026). <i>Large-scale imaging of cellular actin networks at single
    filament resolution using montage cryo-electron tomography</i>. Institute of Science
    and Technology Austria . <a href="https://doi.org/10.15479/AT-ISTA-22744">https://doi.org/10.15479/AT-ISTA-22744</a>
  chicago: Javoor, Manjunath. “Large-Scale Imaging of Cellular Actin Networks at Single
    Filament Resolution Using Montage Cryo-Electron Tomography.” Institute of Science
    and Technology Austria , 2026. <a href="https://doi.org/10.15479/AT-ISTA-22744">https://doi.org/10.15479/AT-ISTA-22744</a>.
  ieee: M. Javoor, “Large-scale imaging of cellular actin networks at single filament
    resolution using montage cryo-electron tomography,” Institute of Science and Technology
    Austria , 2026.
  ista: Javoor M. 2026. Large-scale imaging of cellular actin networks at single filament
    resolution using montage cryo-electron tomography. Institute of Science and Technology
    Austria .
  mla: Javoor, Manjunath. <i>Large-Scale Imaging of Cellular Actin Networks at Single
    Filament Resolution Using Montage Cryo-Electron Tomography</i>. Institute of Science
    and Technology Austria , 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22744">10.15479/AT-ISTA-22744</a>.
  short: M. Javoor, Large-Scale Imaging of Cellular Actin Networks at Single Filament
    Resolution Using Montage Cryo-Electron Tomography, Institute of Science and Technology
    Austria , 2026.
corr_author: '1'
date_created: 2026-08-21T09:11:04Z
date_published: 2026-08-21T00:00:00Z
date_updated: 2026-09-03T09:36:24Z
day: '21'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: FlSc
- _id: MiSi
doi: 10.15479/AT-ISTA-22744
doi_confirm: '1'
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has_accepted_license: '1'
keyword:
- Actin cytoskeleton
- Cell migration
- cryo-electron tomography
language:
- iso: eng
month: '08'
oa_version: None
page: '121'
project:
- _id: bd980d18-d553-11ed-ba76-ceaa645c97eb
  grant_number: '101076260'
  name: A molecular atlas of Actin filament IDentities in the cell motility machinery
- _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd
  grant_number: '101071793'
  name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal
    pushing forces'
publication_identifier:
  isbn:
  - '978-3-99078-090-9 '
  issn:
  - 2663-337X
publication_status: published
publisher: 'Institute of Science and Technology Austria '
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supervisor:
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  full_name: Schur, Florian KM
  id: 48AD8942-F248-11E8-B48F-1D18A9856A87
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  orcid: 0000-0003-4790-8078
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  id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
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  orcid: 0000-0002-6620-9179
title: Large-scale imaging of cellular actin networks at single filament resolution
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  short: CC BY-NC-ND (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: publisher
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acknowledged_ssus:
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- _id: LifeSc
acknowledgement: "I am also grateful for the financial support that made this work
  possible, including the\r\nEuropean Research Council (ERC Starting Grant 101041551),
  the Austrian Science\r\nFund (FWF, Cluster of Excellence 10.55776/COE16), the GFF
  Lower Austria FTI\r\nStrategy Dissertation Fellowship (FTI21-D-046), and the FENS/IBRO-PERC\r\nExchange
  Fellowship. "
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
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  id: cf391e77-ec3c-11ea-a124-d69323410b58
  last_name: Vijatovic
  orcid: 0000-0002-5494-0941
citation:
  ama: Vijatovic D. Dissecting the molecular and functional basis of motor control
    in the frog Xenopus laevis. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22667">10.15479/AT-ISTA-22667</a>
  apa: Vijatovic, D. (2026). <i>Dissecting the molecular and functional basis of motor
    control in the frog Xenopus laevis</i>. Institute of Science and Technology Austria.
    <a href="https://doi.org/10.15479/AT-ISTA-22667">https://doi.org/10.15479/AT-ISTA-22667</a>
  chicago: Vijatovic, David. “Dissecting the Molecular and Functional Basis of Motor
    Control in the Frog Xenopus Laevis.” Institute of Science and Technology Austria,
    2026. <a href="https://doi.org/10.15479/AT-ISTA-22667">https://doi.org/10.15479/AT-ISTA-22667</a>.
  ieee: D. Vijatovic, “Dissecting the molecular and functional basis of motor control
    in the frog Xenopus laevis,” Institute of Science and Technology Austria, 2026.
  ista: Vijatovic D. 2026. Dissecting the molecular and functional basis of motor
    control in the frog Xenopus laevis. Institute of Science and Technology Austria.
  mla: Vijatovic, David. <i>Dissecting the Molecular and Functional Basis of Motor
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    2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22667">10.15479/AT-ISTA-22667</a>.
  short: D. Vijatovic, Dissecting the Molecular and Functional Basis of Motor Control
    in the Frog Xenopus Laevis, Institute of Science and Technology Austria, 2026.
corr_author: '1'
date_created: 2026-08-10T13:44:30Z
date_published: 2026-08-10T00:00:00Z
date_updated: 2026-09-04T10:02:55Z
day: '10'
ddc:
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department:
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  name: Development of Viral Vectors for Amphibian Gene Delivery and Manipulation
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supervisor:
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  full_name: Sweeney, Lora Beatrice Jaeger
  id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
  last_name: Sweeney
  orcid: 0000-0001-9242-5601
title: Dissecting the molecular and functional basis of motor control in the frog
  Xenopus laevis
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2026'
...
---
OA_place: repository
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acknowledged_ssus:
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- _id: LifeSc
article_processing_charge: No
author:
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  full_name: Tong, Xin
  id: 50F65CDC-AA30-11E9-A72B-8A12E6697425
  last_name: Tong
citation:
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    movies. 2026. doi:<a href="https://doi.org/10.15479/AT-ISTA-22777">10.15479/AT-ISTA-22777</a>
  apa: Tong, X. (2026). Towards a deeper understanding of meroblastic cleavage - supplementary
    movies. Institute of Science and Technology Austria. <a href="https://doi.org/10.15479/AT-ISTA-22777">https://doi.org/10.15479/AT-ISTA-22777</a>
  chicago: Tong, Xin. “Towards a Deeper Understanding of Meroblastic Cleavage - Supplementary
    Movies.” Institute of Science and Technology Austria, 2026. <a href="https://doi.org/10.15479/AT-ISTA-22777">https://doi.org/10.15479/AT-ISTA-22777</a>.
  ieee: X. Tong, “Towards a deeper understanding of meroblastic cleavage - supplementary
    movies.” Institute of Science and Technology Austria, 2026.
  ista: Tong X. 2026. Towards a deeper understanding of meroblastic cleavage - supplementary
    movies, Institute of Science and Technology Austria, <a href="https://doi.org/10.15479/AT-ISTA-22777">10.15479/AT-ISTA-22777</a>.
  mla: Tong, Xin. <i>Towards a Deeper Understanding of Meroblastic Cleavage - Supplementary
    Movies</i>. Institute of Science and Technology Austria, 2026, doi:<a href="https://doi.org/10.15479/AT-ISTA-22777">10.15479/AT-ISTA-22777</a>.
  short: X. Tong, (2026).
corr_author: '1'
date_created: 2026-09-03T10:48:15Z
date_published: 2026-09-04T00:00:00Z
date_updated: 2026-09-04T12:49:45Z
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month: '9'
oa: 1
oa_version: None
project:
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  name: NOMIS Fellowship Program
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  call_identifier: H2020
  grant_number: '851288'
  name: Design Principles of Branching Morphogenesis
publisher: Institute of Science and Technology Austria
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status: public
title: Towards a deeper understanding of meroblastic cleavage - supplementary movies
tmp:
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type: research_data
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...
---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
PlanS_conform: '1'
_id: '18706'
abstract:
- lang: eng
  text: "We prove discrete-to-continuum convergence for dynamical optimal transport
    on  Zd\r\n -periodic graphs with cost functional having linear growth at infinity.
    This result provides an answer to a problem left open by Gladbach, Kopfer, Maas,
    and Portinale (Calc Var Partial Differential Equations 62(5), 2023), where the
    convergence behaviour of discrete boundary-value dynamical transport problems
    is proved under the stronger assumption of superlinear growth. Our result extends
    the known literature to some important classes of examples, such as scaling limits
    of  1 -Wasserstein transport problems. Similarly to what happens in the quadratic
    case, the geometry of the graph plays a crucial role in the structure of the limit
    cost function, as we discuss in the final part of this work, which includes some
    visual representations."
acknowledgement: L.P. gratefully acknowledges fundings from the Deutsche Forschungsgemeinschaft
  (DFG, German Research Foundation) under Germany’s Excellence Strategy – GZ 2047/1,
  Projekt-ID 390685813. F.Q. gratefully acknowledges support from the Austrian Science
  Fund (FWF) project 10.55776/F65.
article_processing_charge: Yes
article_type: original
author:
- first_name: Lorenzo
  full_name: Portinale, Lorenzo
  id: 30AD2CBC-F248-11E8-B48F-1D18A9856A87
  last_name: Portinale
- first_name: Filippo
  full_name: Quattrocchi, Filippo
  id: 3ebd6ba8-edfb-11eb-afb5-91a9745ba308
  last_name: Quattrocchi
  orcid: 0009-0000-9773-1931
citation:
  ama: Portinale L, Quattrocchi F. Discrete-to-continuum limits of optimal transport
    with linear growth on periodic graphs. <i>European Journal of Applied Mathematics</i>.
    2026;37(3):614-642. doi:<a href="https://doi.org/10.1017/s0956792524000810">10.1017/s0956792524000810</a>
  apa: Portinale, L., &#38; Quattrocchi, F. (2026). Discrete-to-continuum limits of
    optimal transport with linear growth on periodic graphs. <i>European Journal of
    Applied Mathematics</i>. Cambridge University Press. <a href="https://doi.org/10.1017/s0956792524000810">https://doi.org/10.1017/s0956792524000810</a>
  chicago: Portinale, Lorenzo, and Filippo Quattrocchi. “Discrete-to-Continuum Limits
    of Optimal Transport with Linear Growth on Periodic Graphs.” <i>European Journal
    of Applied Mathematics</i>. Cambridge University Press, 2026. <a href="https://doi.org/10.1017/s0956792524000810">https://doi.org/10.1017/s0956792524000810</a>.
  ieee: L. Portinale and F. Quattrocchi, “Discrete-to-continuum limits of optimal
    transport with linear growth on periodic graphs,” <i>European Journal of Applied
    Mathematics</i>, vol. 37, no. 3. Cambridge University Press, pp. 614–642, 2026.
  ista: Portinale L, Quattrocchi F. 2026. Discrete-to-continuum limits of optimal
    transport with linear growth on periodic graphs. European Journal of Applied Mathematics.
    37(3), 614–642.
  mla: Portinale, Lorenzo, and Filippo Quattrocchi. “Discrete-to-Continuum Limits
    of Optimal Transport with Linear Growth on Periodic Graphs.” <i>European Journal
    of Applied Mathematics</i>, vol. 37, no. 3, Cambridge University Press, 2026,
    pp. 614–42, doi:<a href="https://doi.org/10.1017/s0956792524000810">10.1017/s0956792524000810</a>.
  short: L. Portinale, F. Quattrocchi, European Journal of Applied Mathematics 37
    (2026) 614–642.
das_tickbox: '0'
date_created: 2024-12-23T11:03:59Z
date_published: 2026-06-01T00:00:00Z
date_updated: 2026-09-04T22:31:07Z
day: '01'
ddc:
- '500'
department:
- _id: GradSch
- _id: JaMa
doi: 10.1017/s0956792524000810
external_id:
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  - '001381435800001'
file:
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  file_size: 612317
  relation: main_file
  success: 1
file_date_updated: 2026-07-23T05:55:03Z
has_accepted_license: '1'
intvolume: '        37'
isi: 1
issue: '3'
keyword:
- optimal transport
- discrete-to-continuum
- homogenisation
- linear growth
- gamma-convergence
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 614-642
project:
- _id: fc31cba2-9c52-11eb-aca3-ff467d239cd2
  grant_number: F6504
  name: Taming Complexity in Partial Differential Systems
publication: European Journal of Applied Mathematics
publication_identifier:
  eissn:
  - 1469-4425
  issn:
  - 0956-7925
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
related_material:
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  - id: '20563'
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    status: public
researchdata_availability: no
scopus_import: '1'
status: public
supplementarymaterial: no
title: Discrete-to-continuum limits of optimal transport with linear growth on periodic
  graphs
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2026'
...
---
OA_place: publisher
OA_type: gold
_id: '22007'
abstract:
- lang: eng
  text: "Truncation of cryptographic outputs is a technique that was recently introduced
    in Baldimtsi et al. [Foteini Baldimtsi et al., 2022]. The general idea is to try
    out many inputs to some cryptographic algorithm until the output (e.g. a public-key
    or some hash value) falls into some sparse set and thus can be compressed: by
    trying out an expected 2^k different inputs one will find an output that starts
    with k zeros.\r\nUsing such truncation one can for example save substantial gas
    fees on Blockchains where storing values is very expensive. While [Foteini Baldimtsi
    et al., 2022] show that truncation preserves the security of the underlying primitive,
    they only consider a setting without preprocessing. In this work we show that
    lower bounds on the time-space tradeoff for inverting random functions and permutations
    also hold with truncation, except for parameters ranges where the bound fails
    to hold for \"trivial\" reasons.\r\nConcretely, it’s known that any algorithm
    that inverts a random function or permutation with range N making T queries and
    using S bits of auxiliary input must satisfy S⋅ T ≥ Nlog N. This lower bound no
    longer holds in the truncated setting where one must only invert a challenge from
    a range of size N/2^k, as now one can simply save the replies to all N/2^k challenges,
    which requires S = log N⋅ N /2^k bits and allows to invert with T = 1 query.\r\nWe
    show that with truncation, whenever S is somewhat smaller than the log N⋅ N /2^k
    bits required to store the entire truncated function table, the known S⋅ T ≥ Nlog
    N lower bound applies."
alternative_title:
- LIPIcs
article_number: 4:1-4:10
article_processing_charge: Yes
author:
- first_name: Krzysztof Z
  full_name: Pietrzak, Krzysztof Z
  id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
  last_name: Pietrzak
  orcid: 0000-0002-9139-1654
- first_name: Pengxiang
  full_name: Wang, Pengxiang
  last_name: Wang
citation:
  ama: 'Pietrzak KZ, Wang P. Time-space tradeoffs of truncation with preprocessing.
    In: <i>6th Conference on Information-Theoretic Cryptography</i>. Vol 343. Schloss
    Dagstuhl - Leibniz-Zentrum für Informatik; 2025. doi:<a href="https://doi.org/10.4230/LIPIcs.ITC.2025.4">10.4230/LIPIcs.ITC.2025.4</a>'
  apa: 'Pietrzak, K. Z., &#38; Wang, P. (2025). Time-space tradeoffs of truncation
    with preprocessing. In <i>6th Conference on Information-Theoretic Cryptography</i>
    (Vol. 343). Santa Barbara, CA, United States: Schloss Dagstuhl - Leibniz-Zentrum
    für Informatik. <a href="https://doi.org/10.4230/LIPIcs.ITC.2025.4">https://doi.org/10.4230/LIPIcs.ITC.2025.4</a>'
  chicago: Pietrzak, Krzysztof Z, and Pengxiang Wang. “Time-Space Tradeoffs of Truncation
    with Preprocessing.” In <i>6th Conference on Information-Theoretic Cryptography</i>,
    Vol. 343. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2025. <a href="https://doi.org/10.4230/LIPIcs.ITC.2025.4">https://doi.org/10.4230/LIPIcs.ITC.2025.4</a>.
  ieee: K. Z. Pietrzak and P. Wang, “Time-space tradeoffs of truncation with preprocessing,”
    in <i>6th Conference on Information-Theoretic Cryptography</i>, Santa Barbara,
    CA, United States, 2025, vol. 343.
  ista: 'Pietrzak KZ, Wang P. 2025. Time-space tradeoffs of truncation with preprocessing.
    6th Conference on Information-Theoretic Cryptography. ITC: Information Theoretic
    Cryptography, LIPIcs, vol. 343, 4:1-4:10.'
  mla: Pietrzak, Krzysztof Z., and Pengxiang Wang. “Time-Space Tradeoffs of Truncation
    with Preprocessing.” <i>6th Conference on Information-Theoretic Cryptography</i>,
    vol. 343, 4:1-4:10, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2025, doi:<a
    href="https://doi.org/10.4230/LIPIcs.ITC.2025.4">10.4230/LIPIcs.ITC.2025.4</a>.
  short: K.Z. Pietrzak, P. Wang, in:, 6th Conference on Information-Theoretic Cryptography,
    Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2025.
conference:
  end_date: 2025-08-17
  location: Santa Barbara, CA, United States
  name: 'ITC: Information Theoretic Cryptography'
  start_date: 2025-08-16
corr_author: '1'
cryptoeprintid: 1
das_tickbox: '0'
date_created: 2026-06-14T22:01:45Z
date_published: 2025-09-08T00:00:00Z
date_updated: 2026-06-22T08:57:41Z
day: '08'
ddc:
- '000'
department:
- _id: KrPi
doi: 10.4230/LIPIcs.ITC.2025.4
external_id:
  cryptoeprintid:
  - 2025/723
file:
- access_level: open_access
  checksum: 3f791b03df26853342855a9d9581cb58
  content_type: application/pdf
  creator: dernst
  date_created: 2026-06-22T08:54:32Z
  date_updated: 2026-06-22T08:54:32Z
  file_id: '22118'
  file_name: 2025_LIPIcs_Pietrzak.pdf
  file_size: 772046
  relation: main_file
  success: 1
file_date_updated: 2026-06-22T08:54:32Z
has_accepted_license: '1'
intvolume: '       343'
keyword:
- Time-Space Lower Bounds
- Blockchains
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
publication: 6th Conference on Information-Theoretic Cryptography
publication_identifier:
  eissn:
  - 1868-8969
  isbn:
  - '9783959773850'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: Time-space tradeoffs of truncation with preprocessing
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 343
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '12662'
abstract:
- lang: eng
  text: 'Modern machine learning tasks often require considering not just one but
    multiple objectives. For example, besides the prediction quality, this could be
    the efficiency, robustness or fairness of the learned models, or any of their
    combinations. Multi-objective learning offers a natural framework for handling
    such problems without having to commit to early trade-offs. Surprisingly, statistical
    learning theory so far offers almost no insight into the generalization properties
    of multi-objective learning. In this work, we make first steps to fill this gap:
    We establish foundational generalization bounds for the multi-objective setting
    as well as generalization and excess bounds for learning with scalarizations.
    We also provide the first theoretical analysis of the relation between the Pareto-optimal
    sets of the true objectives and the Pareto-optimal sets of their empirical approximations
    from training data. In particular, we show a surprising asymmetry: All Pareto-optimal
    solutions can be approximated by empirically Pareto-optimal ones, but not vice
    versa.'
acknowledgement: Open access funding provided by Institute of Science and Technology
  (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Peter
  full_name: Súkeník, Peter
  id: d64d6a8d-eb8e-11eb-b029-96fd216dec3c
  last_name: Súkeník
- first_name: Christoph
  full_name: Lampert, Christoph
  id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
  last_name: Lampert
  orcid: 0000-0001-8622-7887
citation:
  ama: Súkeník P, Lampert C. Generalization in multi-objective machine learning. <i>Neural
    Computing and Applications</i>. 2025;37:24669–24683. doi:<a href="https://doi.org/10.1007/s00521-024-10616-1">10.1007/s00521-024-10616-1</a>
  apa: Súkeník, P., &#38; Lampert, C. (2025). Generalization in multi-objective machine
    learning. <i>Neural Computing and Applications</i>. Springer Nature. <a href="https://doi.org/10.1007/s00521-024-10616-1">https://doi.org/10.1007/s00521-024-10616-1</a>
  chicago: Súkeník, Peter, and Christoph Lampert. “Generalization in Multi-Objective
    Machine Learning.” <i>Neural Computing and Applications</i>. Springer Nature,
    2025. <a href="https://doi.org/10.1007/s00521-024-10616-1">https://doi.org/10.1007/s00521-024-10616-1</a>.
  ieee: P. Súkeník and C. Lampert, “Generalization in multi-objective machine learning,”
    <i>Neural Computing and Applications</i>, vol. 37. Springer Nature, pp. 24669–24683,
    2025.
  ista: Súkeník P, Lampert C. 2025. Generalization in multi-objective machine learning.
    Neural Computing and Applications. 37, 24669–24683.
  mla: Súkeník, Peter, and Christoph Lampert. “Generalization in Multi-Objective Machine
    Learning.” <i>Neural Computing and Applications</i>, vol. 37, Springer Nature,
    2025, pp. 24669–24683, doi:<a href="https://doi.org/10.1007/s00521-024-10616-1">10.1007/s00521-024-10616-1</a>.
  short: P. Súkeník, C. Lampert, Neural Computing and Applications 37 (2025) 24669–24683.
corr_author: '1'
date_created: 2023-02-20T08:23:06Z
date_published: 2025-10-01T00:00:00Z
date_updated: 2025-12-30T06:39:56Z
day: '01'
ddc:
- '004'
department:
- _id: ChLa
doi: 10.1007/s00521-024-10616-1
external_id:
  arxiv:
  - '2208.13499'
file:
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  creator: dernst
  date_created: 2025-12-30T06:39:11Z
  date_updated: 2025-12-30T06:39:11Z
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language:
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month: '10'
oa: 1
oa_version: Published Version
page: 24669–24683
publication: Neural Computing and Applications
publication_identifier:
  eissn:
  - 1433-3058
  issn:
  - 0941-0643
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Generalization in multi-objective machine learning
tmp:
  image: /images/cc_by.png
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  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 37
year: '2025'
...
---
OA_place: publisher
OA_type: gold
_id: '20820'
abstract:
- lang: eng
  text: 'The high computational costs of large language models (LLMs) have led to
    a flurry of research on LLM compression, via methods such as quantization, sparsification,
    or structured pruning. A new frontier in this area is given by dynamic, non-uniform
    compression methods, which adjust the compression levels (e.g., sparsity) per-block
    or even per-layer in order to minimize accuracy loss, while guaranteeing a global
    compression threshold. Yet, current methods rely on estimating the "importance"
    of a given layer, implicitly assuming that layers contribute independently to
    the overall compression error. We begin from the motivating observation that this
    independence assumption does not generally hold for LLM compression: pruning a
    model further may even significantly recover performance. To address this, we
    propose EvoPress, a novel evolutionary framework for dynamic LLM compression.
    By formulating dynamic compression as a general optimization problem, EvoPress
    identifies optimal compression profiles in a highly efficient manner, and generalizes
    across diverse models and compression techniques. Via EvoPress, we achieve state-of-the-art
    performance for dynamic compression of Llama, Mistral, and Phi models, setting
    new benchmarks for structural pruning (block/layer dropping), unstructured sparsity,
    and quantization with dynamic bitwidths.'
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Oliver
  full_name: Sieberling, Oliver
  last_name: Sieberling
- first_name: Denis
  full_name: Kuznedelev, Denis
  last_name: Kuznedelev
- first_name: Eldar
  full_name: Kurtic, Eldar
  id: 47beb3a5-07b5-11eb-9b87-b108ec578218
  last_name: Kurtic
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
citation:
  ama: 'Sieberling O, Kuznedelev D, Kurtic E, Alistarh D-A. EvoPress: Accurate dynamic
    model compression via evolutionary search. In: <i>42nd International Conference
    on Machine Learning</i>. Vol 267. ML Research Press; 2025:55556-55590.'
  apa: 'Sieberling, O., Kuznedelev, D., Kurtic, E., &#38; Alistarh, D.-A. (2025).
    EvoPress: Accurate dynamic model compression via evolutionary search. In <i>42nd
    International Conference on Machine Learning</i> (Vol. 267, pp. 55556–55590).
    Vancouver, Canada: ML Research Press.'
  chicago: 'Sieberling, Oliver, Denis Kuznedelev, Eldar Kurtic, and Dan-Adrian Alistarh.
    “EvoPress: Accurate Dynamic Model Compression via Evolutionary Search.” In <i>42nd
    International Conference on Machine Learning</i>, 267:55556–90. ML Research Press,
    2025.'
  ieee: 'O. Sieberling, D. Kuznedelev, E. Kurtic, and D.-A. Alistarh, “EvoPress: Accurate
    dynamic model compression via evolutionary search,” in <i>42nd International Conference
    on Machine Learning</i>, Vancouver, Canada, 2025, vol. 267, pp. 55556–55590.'
  ista: 'Sieberling O, Kuznedelev D, Kurtic E, Alistarh D-A. 2025. EvoPress: Accurate
    dynamic model compression via evolutionary search. 42nd International Conference
    on Machine Learning. ICML: International Conference on Machine Learning, PMLR,
    vol. 267, 55556–55590.'
  mla: 'Sieberling, Oliver, et al. “EvoPress: Accurate Dynamic Model Compression via
    Evolutionary Search.” <i>42nd International Conference on Machine Learning</i>,
    vol. 267, ML Research Press, 2025, pp. 55556–90.'
  short: O. Sieberling, D. Kuznedelev, E. Kurtic, D.-A. Alistarh, in:, 42nd International
    Conference on Machine Learning, ML Research Press, 2025, pp. 55556–55590.
conference:
  end_date: 2025-07-19
  location: Vancouver, Canada
  name: 'ICML: International Conference on Machine Learning'
  start_date: 2025-07-13
corr_author: '1'
date_created: 2025-12-14T23:02:05Z
date_published: 2025-05-01T00:00:00Z
date_updated: 2025-12-16T12:34:32Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
external_id:
  arxiv:
  - '2410.14649'
file:
- access_level: open_access
  checksum: 1d744fbaeb199b08e8b6f48bc0dd047e
  content_type: application/pdf
  creator: dernst
  date_created: 2025-12-16T12:32:40Z
  date_updated: 2025-12-16T12:32:40Z
  file_id: '20828'
  file_name: 2025_ICML_Sieberling.pdf
  file_size: 908379
  relation: main_file
  success: 1
file_date_updated: 2025-12-16T12:32:40Z
has_accepted_license: '1'
intvolume: '       267'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 55556-55590
publication: 42nd International Conference on Machine Learning
publication_identifier:
  eissn:
  - 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'EvoPress: Accurate dynamic model compression via evolutionary search'
tmp:
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  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 267
year: '2025'
...
---
OA_place: publisher
OA_type: gold
_id: '20821'
abstract:
- lang: eng
  text: Modern deep neural networks exhibit heterogeneity across numerous layers of
    various types such as residuals, multi-head attention, etc., due to varying structures
    (dimensions, activation functions, etc.), distinct representation characteristics,
    which impact predictions. We develop a general layer-wise quantization framework
    with tight variance and code-length bounds, adapting to the heterogeneities over
    the course of training. We then apply a new layer-wise quantization technique
    within distributed variational inequalities (VIs), proposing a novel Quantized
    Optimistic Dual Averaging (QODA) algorithm with adaptive learning rates, which
    achieves competitive convergence rates for monotone VIs. We empirically show that
    QODA achieves up to a 150% speedup over the baselines in end-to-end training time
    for training Wasserstein GAN on 12+GPUs.
acknowledgement: "This work was supported by Hasler Foundation Program: Hasler Responsible
  AI (project number 21043). The research was also sponsored by the Army Research
  Office and was accomplished under Grant Number W911NF-24-1-0048. This work was further
  funded by the Swiss National Science Foundation (SNSF) under grant number 200021_205011.
  We also acknowledge project A11 of the Swiss National Supercomputing Centre (CSCS)
  for providing computing resources. Dan Alistarh and Ilia Markov were supported in
  part through the ERC Proofof-Concept grant FastML (Grant Agreement 101158077). Ali
  Ramezani-Kebrya was supported by the Research Council of Norway through FRIPRO Grant
  under project number 356103, its Centres of Excellence scheme, Integreat - Norwegian
  Centre for knowledge-driven machine learning under\r\nproject number 332645 - and
  its Centre for Research-based Innovation funding scheme (Visual Intelligence under
  grant no. 309439)."
alternative_title:
- PMLR
article_processing_charge: No
arxiv: 1
author:
- first_name: Anh Duc
  full_name: Nguyen, Anh Duc
  last_name: Nguyen
- first_name: Ilia
  full_name: Markov, Ilia
  id: D0CF4148-C985-11E9-8066-0BDEE5697425
  last_name: Markov
- first_name: Frank Zhengqing
  full_name: Wu, Frank Zhengqing
  last_name: Wu
- first_name: Ali
  full_name: Ramezani-Kebrya, Ali
  last_name: Ramezani-Kebrya
- first_name: Kimon
  full_name: Antonakopoulos, Kimon
  last_name: Antonakopoulos
- first_name: Dan-Adrian
  full_name: Alistarh, Dan-Adrian
  id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
  last_name: Alistarh
  orcid: 0000-0003-3650-940X
- first_name: Volkan
  full_name: Cevher, Volkan
  last_name: Cevher
citation:
  ama: 'Nguyen AD, Markov I, Wu FZ, et al. Layer-wise quantization for quantized optimistic
    dual averaging. In: <i>42nd International Conference on Machine Learning</i>.
    Vol 267. ML Research Press; 2025:46026-46072.'
  apa: 'Nguyen, A. D., Markov, I., Wu, F. Z., Ramezani-Kebrya, A., Antonakopoulos,
    K., Alistarh, D.-A., &#38; Cevher, V. (2025). Layer-wise quantization for quantized
    optimistic dual averaging. In <i>42nd International Conference on Machine Learning</i>
    (Vol. 267, pp. 46026–46072). Vancouver, Canada: ML Research Press.'
  chicago: Nguyen, Anh Duc, Ilia Markov, Frank Zhengqing Wu, Ali Ramezani-Kebrya,
    Kimon Antonakopoulos, Dan-Adrian Alistarh, and Volkan Cevher. “Layer-Wise Quantization
    for Quantized Optimistic Dual Averaging.” In <i>42nd International Conference
    on Machine Learning</i>, 267:46026–72. ML Research Press, 2025.
  ieee: A. D. Nguyen <i>et al.</i>, “Layer-wise quantization for quantized optimistic
    dual averaging,” in <i>42nd International Conference on Machine Learning</i>,
    Vancouver, Canada, 2025, vol. 267, pp. 46026–46072.
  ista: 'Nguyen AD, Markov I, Wu FZ, Ramezani-Kebrya A, Antonakopoulos K, Alistarh
    D-A, Cevher V. 2025. Layer-wise quantization for quantized optimistic dual averaging.
    42nd International Conference on Machine Learning. ICML: International Conference
    on Machine Learning, PMLR, vol. 267, 46026–46072.'
  mla: Nguyen, Anh Duc, et al. “Layer-Wise Quantization for Quantized Optimistic Dual
    Averaging.” <i>42nd International Conference on Machine Learning</i>, vol. 267,
    ML Research Press, 2025, pp. 46026–72.
  short: A.D. Nguyen, I. Markov, F.Z. Wu, A. Ramezani-Kebrya, K. Antonakopoulos, D.-A.
    Alistarh, V. Cevher, in:, 42nd International Conference on Machine Learning, ML
    Research Press, 2025, pp. 46026–46072.
conference:
  end_date: 2025-07-19
  location: Vancouver, Canada
  name: 'ICML: International Conference on Machine Learning'
  start_date: 2025-07-13
date_created: 2025-12-14T23:02:06Z
date_published: 2025-05-01T00:00:00Z
date_updated: 2025-12-16T12:46:54Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
external_id:
  arxiv:
  - '2505.14371'
file:
- access_level: open_access
  checksum: a7edf0e4304171a3e035842b3aab1704
  content_type: application/pdf
  creator: dernst
  date_created: 2025-12-16T12:45:41Z
  date_updated: 2025-12-16T12:45:41Z
  file_id: '20830'
  file_name: 2025_ICML_Nguyen.pdf
  file_size: 756213
  relation: main_file
  success: 1
file_date_updated: 2025-12-16T12:45:41Z
has_accepted_license: '1'
intvolume: '       267'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 46026-46072
project:
- _id: 8e35c14b-16d5-11f0-9cad-a3fc35339161
  grant_number: '101158077'
  name: 'FastML: Efficient and Cost-Effective Distributed Machine Learning'
publication: 42nd International Conference on Machine Learning
publication_identifier:
  eissn:
  - 2640-3498
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Layer-wise quantization for quantized optimistic dual averaging
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 267
year: '2025'
...
