--- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '22306' abstract: - lang: eng text: "The AP3 complex mediates cargo sorting and carrier assembly for the trafficking of transmembrane proteins from endosomes to lysosomes. AP3 is generally believed to localize to clathrin-free, ARF1-positive, elongated carriers in cells, but the architecture of AP3-based coats was unknown. Using in vitro reconstitution and cryo–electron tomography, we demonstrate that AP3:ARF1 spontaneously remodels membranes containing cargo and the phosphoinositide PI(3,5)P\r\n 2\r\n \ into tubular structures coated in spiraling rows of AP3 arches and ARF1 dimers. Targeted point mutations disrupting critical AP3:ARF1 and AP3:AP3 lattice interfaces disrupt AP3 recruitment, carrier formation, and lysosomal cargo trafficking in cells. We propose that AP3 generates tubular carriers on endosomes by organizing ARF1 dimers into elongated membrane-deforming arrays while simultaneously selecting cargo. By demonstrating that AP3:ARF1 can generate carriers without using a clathrin lattice, we explain the clathrin independence of AP3-mediated trafficking." acknowledgement: "We thank P. Luzio, N. Bright, and M. S. Robinson for helpful discussions;\r\nJ. Stacey and Y. Fujiharu for technical discussions and assistance; F. Beck for assistance with\r\ncomputing infrastructure; and M. Riggi for discussion of data presentation and figure design.\r\nCryo-E\r\nM data was collected at the Department of Cell and Virus Structure, Max Planck Institute\r\nof Biochemistry. Funding: This work was funded by: the Wellcome Trust, Wellcome Discovery\r\nAward 227915/Z/23/Z (to D.J.O., J.A.G.B., and D.G.S.) and Wellcome PRF 207455/Z/17/Z (to\r\nD.J.O.); the Max Planck Society (to J.A.G.B.); the Medical Research Council (UKRI) MC_\r\nUP_1201/16 (to J.A.G.B.) and MRC DT P MR/N013433/1 (to J.G.G.K.); EMBO Long-term\r\nPostdoctoral Fellowship ALT F-383-\r\n2022\r\n(to G.T.); and the Wellcome Trust/Royal Society, Sir\r\nHenry Dale Fellowship 210481 (to D.C.G) and the Biotechnology and Biological Sciences\r\nResearch Council (UKRI) responsive mode grants BB/W005905/1 and UKRI715 (to D.C.G.)." article_number: eaed1529 article_processing_charge: Yes article_type: original author: - first_name: Jonathan G.G. full_name: Kaufman, Jonathan G.G. last_name: Kaufman - first_name: Grigory full_name: Tagiltsev, Grigory last_name: Tagiltsev - first_name: Danièle S. full_name: Stalder, Danièle S. last_name: Stalder - first_name: Rebecca J. full_name: Taylor, Rebecca J. last_name: Taylor - first_name: Ioana full_name: Sava, Ioana last_name: Sava - first_name: Hui full_name: Guo, Hui last_name: Guo - first_name: Katarzyna A. full_name: Ciazynska, Katarzyna A. last_name: Ciazynska - first_name: Nathan R. full_name: Zaccai, Nathan R. last_name: Zaccai - first_name: Sally R. full_name: Gray, Sally R. last_name: Gray - first_name: Yvonne full_name: Vallis, Yvonne id: 05A2795C-31B5-11EA-83A7-7DA23DDC885E last_name: Vallis orcid: 0000-0002-5408-5906 - first_name: Stefan full_name: Höning, Stefan last_name: Höning - first_name: Bernard T. full_name: Kelly, Bernard T. last_name: Kelly - first_name: David C. full_name: Gershlick, David C. last_name: Gershlick - first_name: John A.G. full_name: Briggs, John A.G. last_name: Briggs - first_name: David J. full_name: Owen, David J. last_name: Owen citation: ama: Kaufman JGG, Tagiltsev G, Stalder DS, et al. Architecture of clathrin-independent AP3:ARF1-coated carriers. Science Advances. 2026;12(20). doi:10.1126/sciadv.aed1529 apa: Kaufman, J. G. G., Tagiltsev, G., Stalder, D. S., Taylor, R. J., Sava, I., Guo, H., … Owen, D. J. (2026). Architecture of clathrin-independent AP3:ARF1-coated carriers. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aed1529 chicago: Kaufman, Jonathan G.G., Grigory Tagiltsev, Danièle S. Stalder, Rebecca J. Taylor, Ioana Sava, Hui Guo, Katarzyna A. Ciazynska, et al. “Architecture of Clathrin-Independent AP3:ARF1-Coated Carriers.” Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.aed1529. ieee: J. G. G. Kaufman et al., “Architecture of clathrin-independent AP3:ARF1-coated carriers,” Science Advances, vol. 12, no. 20. AAAS, 2026. ista: Kaufman JGG, Tagiltsev G, Stalder DS, Taylor RJ, Sava I, Guo H, Ciazynska KA, Zaccai NR, Gray SR, Vallis Y, Höning S, Kelly BT, Gershlick DC, Briggs JAG, Owen DJ. 2026. Architecture of clathrin-independent AP3:ARF1-coated carriers. Science Advances. 12(20), eaed1529. mla: Kaufman, Jonathan G. G., et al. “Architecture of Clathrin-Independent AP3:ARF1-Coated Carriers.” Science Advances, vol. 12, no. 20, eaed1529, AAAS, 2026, doi:10.1126/sciadv.aed1529. short: J.G.G. Kaufman, G. Tagiltsev, D.S. Stalder, R.J. Taylor, I. Sava, H. Guo, K.A. Ciazynska, N.R. Zaccai, S.R. Gray, Y. Vallis, S. Höning, B.T. Kelly, D.C. Gershlick, J.A.G. Briggs, D.J. Owen, Science Advances 12 (2026). das_tickbox: '1' dataavailabilitystatement: "Structures determined by electron microscopy are deposited in the Electron\r\nMicroscopy Data Bank under accession codes EMD-54255,\r\nEMD-54256,\r\nEMD-54257,\r\nand\r\nEMD-54258.\r\nCorresponding molecular models are deposited in the Protein Data Bank under\r\naccession codes 9RTW, 9RTX, 9RTY, and 9RTZ. All additional data and code required to\r\nevaluate and reproduce the results in the paper are present in the paper and/or the\r\nsupplementary materials. Any code used is explicitly stated and available in the original\r\npublications. Plasmids and cell lines can be requested by writing to D.C.G. (dg553@ cam. ac. uk)\r\nor D.J.O. (djo30@ cam. ac. uk). All reasonable requests for materials will be honored." date_created: 2026-07-13T10:52:15Z date_published: 2026-05-15T00:00:00Z date_updated: 2026-10-20T08:11:46Z day: '15' ddc: - '570' department: - _id: MaDe doi: 10.1126/sciadv.aed1529 file: - access_level: open_access checksum: 461b5f73941fe6b5df2a129c7563601f content_type: application/pdf creator: dernst date_created: 2026-07-14T06:45:37Z date_updated: 2026-07-14T06:45:37Z file_id: '22331' file_name: 2026_ScienceAdv_Kaufman.pdf file_size: 8269526 relation: main_file success: 1 file_date_updated: 2026-07-14T06:45:37Z fulldoi: https://doi.org/10.1126/sciadv.aed1529 has_accepted_license: '1' intvolume: ' 12' issue: '20' language: - iso: eng month: '05' oa: 1 oa_version: Published Version publication: Science Advances publication_identifier: eissn: - 2375-2548 publication_status: published publisher: AAAS quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Architecture of clathrin-independent AP3:ARF1-coated carriers tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold PlanS_conform: '1' _id: '21340' abstract: - lang: eng text: Equilibrium quantum systems are often described by a gas of weakly interacting normal modes. Bringing such systems far from equilibrium, however, can drastically enhance mode-to-mode interactions. Understanding the resulting liquid is a fundamental question for quantum statistical mechanics and a practical question for engineering driven quantum devices. To tackle this question, we probe the non-equilibrium kinetics of one-dimensional plasmons in a long chain of Josephson junctions. We introduce multimode spectroscopy to controllably study the departure from equilibrium, witnessing the evolution from pairwise coupling between plasma modes at weak driving to dramatic, high-order, cascaded couplings at strong driving. Scaling to many-mode drives, we stimulate interactions between hundreds of modes, resulting in near-continuum internal dynamics. Imaging the resulting non-equilibrium plasmon populations, we then resolve the nonlocal redistribution of energy in the response to a weak perturbation—an explicit verification of the emergence of a strongly interacting, non-equilibrium liquid of plasmons. acknowledged_ssus: - _id: NanoFab - _id: M-Shop acknowledgement: We thank V. Vitelli, M. Fruchart, and A. Burshstein for helpful input. We acknowledge technical support from the Nanofabrication Facility and the MIBA machine shop at IST Austria. This research was supported in part by grant NSF PHY-2309135 to the Kavli Institute for Theoretical Physics (KITP), by the Austrian Science Fund (FWF) SFB F86, and by the NOMIS foundation. article_number: eady7222 article_processing_charge: Yes article_type: original arxiv: 1 author: - first_name: Anton full_name: Bubis, Anton id: 1f6212b5-f795-11ec-9c0c-de4780302890 last_name: Bubis - first_name: Lucia full_name: Vigliotti, Lucia id: 539e1e1a-e604-11ee-a1df-f02b018e5c8c last_name: Vigliotti - first_name: Maksym full_name: Serbyn, Maksym id: 47809E7E-F248-11E8-B48F-1D18A9856A87 last_name: Serbyn orcid: 0000-0002-2399-5827 - first_name: Andrew P full_name: Higginbotham, Andrew P id: 4AD6785A-F248-11E8-B48F-1D18A9856A87 last_name: Higginbotham orcid: 0000-0003-2607-2363 citation: ama: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. Non-equilibrium plasmon liquid in a Josephson junction chain. Science Advances. 2026;12(7). doi:10.1126/sciadv.ady7222 apa: Bubis, A., Vigliotti, L., Serbyn, M., & Higginbotham, A. P. (2026). Non-equilibrium plasmon liquid in a Josephson junction chain. Science Advances. AAAS. https://doi.org/10.1126/sciadv.ady7222 chicago: Bubis, Anton, Lucia Vigliotti, Maksym Serbyn, and Andrew P Higginbotham. “Non-Equilibrium Plasmon Liquid in a Josephson Junction Chain.” Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.ady7222. ieee: A. Bubis, L. Vigliotti, M. Serbyn, and A. P. Higginbotham, “Non-equilibrium plasmon liquid in a Josephson junction chain,” Science Advances, vol. 12, no. 7. AAAS, 2026. ista: Bubis A, Vigliotti L, Serbyn M, Higginbotham AP. 2026. Non-equilibrium plasmon liquid in a Josephson junction chain. Science Advances. 12(7), eady7222. mla: Bubis, Anton, et al. “Non-Equilibrium Plasmon Liquid in a Josephson Junction Chain.” Science Advances, vol. 12, no. 7, eady7222, AAAS, 2026, doi:10.1126/sciadv.ady7222. short: A. Bubis, L. Vigliotti, M. Serbyn, A.P. Higginbotham, Science Advances 12 (2026). corr_author: '1' date_created: 2026-02-22T20:47:38Z date_published: 2026-02-13T00:00:00Z date_updated: 2026-10-20T08:10:46Z day: '13' ddc: - '530' department: - _id: MaSe - _id: AnHi - _id: GeKa doi: 10.1126/sciadv.ady7222 external_id: arxiv: - '2504.09721' file: - access_level: open_access checksum: 8402f322f8f0e858b1d9aac57e306e31 content_type: application/pdf creator: dernst date_created: 2026-02-24T07:23:32Z date_updated: 2026-02-24T07:23:32Z file_id: '21353' file_name: 2026_ScienceAdv_Bubis.pdf file_size: 2775975 relation: main_file success: 1 file_date_updated: 2026-02-24T07:23:32Z fulldoi: https://doi.org/10.1126/sciadv.ady7222 has_accepted_license: '1' intvolume: ' 12' issue: '7' language: - iso: eng month: '02' oa: 1 oa_version: Published Version publication: Science Advances publication_identifier: eissn: - 2375-2548 publication_status: published publisher: AAAS quality_controlled: '1' status: public title: Non-equilibrium plasmon liquid in a Josephson junction chain tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21383' abstract: - lang: eng text: 'Planarian flatworms are known for their remarkable regenerative capacity; however, the precise intercellular communication mechanisms underlying this process remain unsolved. Here, we report the discovery and characterization of abundant extracellular vesicles (EVs) in planarians. Using imaging and molecular analysis, we show conservation of biogenesis, morphology, and protein composition of planarian EVs. Environmental stressors significantly elevate EV release, indicating that planarians dynamically regulate vesicle production. Functionally, planarian EVs mediate intercellular communication by transferring regulatory signals: We find that they shuttle small RNAs that effect systemic RNA interference (RNAi) throughout the organism. Notably, gene knockdown experiments reveal a crucial role for AGO-3, a member of the Argonaute family of proteins, in modulating the association of small interfering RNAs with EVs, linking the intracellular RNAi machinery to EV-based signaling. These findings highlight EVs as pivotal mediators of cell-cell communication in planarians, with broad implications for understanding the coordination of gene regulation and tissue regeneration in animals.' acknowledgement: 'We thank all the Sánchez Alvarado lab members for inputs and discussions. We are grateful to the Stowers Aquatics (particularly the Planarian team), Microscopy, and Molecular Biology core facilities for technical contributions and method development; e. n. lissek and A. Fujii from Oni US and S. Wang from the University of Missouri, Kansas city, for assistance with dStORM imaging; and d. Alburty and A. Page from innovaprep for assisting with the ntA. We also thank M. Miller for the illustrations. This work was supported by the hhMi and Stowers institute. ' article_number: eady1461 article_processing_charge: Yes article_type: original author: - first_name: Vidyanand full_name: Sasidharan, Vidyanand last_name: Sasidharan - first_name: Laura full_name: Ancellotti, Laura last_name: Ancellotti - first_name: Viraj full_name: Doddihal, Viraj id: 034e0824-174b-11ef-b32b-9366a0e70d1c last_name: Doddihal - first_name: Carolyn full_name: Brewster, Carolyn last_name: Brewster - first_name: Frederick full_name: Mann, Frederick last_name: Mann - first_name: Mary Cathleen full_name: McKinney, Mary Cathleen last_name: McKinney - first_name: Joseph full_name: Varberg, Joseph last_name: Varberg - first_name: Eric full_name: Ross, Eric last_name: Ross - first_name: Fengyan full_name: Deng, Fengyan last_name: Deng - first_name: Kexi full_name: Yi, Kexi last_name: Yi - first_name: Alejandro full_name: Sánchez Alvarado, Alejandro last_name: Sánchez Alvarado citation: ama: Sasidharan V, Ancellotti L, Doddihal V, et al. Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians. Science Advances. 2026;12(6). doi:10.1126/sciadv.ady1461 apa: Sasidharan, V., Ancellotti, L., Doddihal, V., Brewster, C., Mann, F., McKinney, M. C., … Sánchez Alvarado, A. (2026). Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians. Science Advances. AAAS. https://doi.org/10.1126/sciadv.ady1461 chicago: Sasidharan, Vidyanand, Laura Ancellotti, Viraj Doddihal, Carolyn Brewster, Frederick Mann, Mary Cathleen McKinney, Joseph Varberg, et al. “Extracellular Vesicles Mediate Stem Cell Signaling and Systemic RNAi in Planarians.” Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.ady1461. ieee: V. Sasidharan et al., “Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians,” Science Advances, vol. 12, no. 6. AAAS, 2026. ista: Sasidharan V, Ancellotti L, Doddihal V, Brewster C, Mann F, McKinney MC, Varberg J, Ross E, Deng F, Yi K, Sánchez Alvarado A. 2026. Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians. Science Advances. 12(6), eady1461. mla: Sasidharan, Vidyanand, et al. “Extracellular Vesicles Mediate Stem Cell Signaling and Systemic RNAi in Planarians.” Science Advances, vol. 12, no. 6, eady1461, AAAS, 2026, doi:10.1126/sciadv.ady1461. short: V. Sasidharan, L. Ancellotti, V. Doddihal, C. Brewster, F. Mann, M.C. McKinney, J. Varberg, E. Ross, F. Deng, K. Yi, A. Sánchez Alvarado, Science Advances 12 (2026). date_created: 2026-03-02T10:08:07Z date_published: 2026-02-01T00:00:00Z date_updated: 2026-10-20T08:11:11Z day: '01' ddc: - '570' department: - _id: CaHe doi: 10.1126/sciadv.ady1461 file: - access_level: open_access checksum: fa9f6dafe3538e2d2872c098e06d1712 content_type: application/pdf creator: dernst date_created: 2026-03-02T14:19:35Z date_updated: 2026-03-02T14:19:35Z file_id: '21389' file_name: 2026_ScienceAdv_Sasidharan.pdf file_size: 2841345 relation: main_file success: 1 file_date_updated: 2026-03-02T14:19:35Z fulldoi: https://doi.org/10.1126/sciadv.ady1461 has_accepted_license: '1' intvolume: ' 12' issue: '6' language: - iso: eng month: '02' oa: 1 oa_version: Published Version publication: Science Advances publication_identifier: eissn: - 2375-2548 publication_status: published publisher: AAAS quality_controlled: '1' scopus_import: '1' status: public title: Extracellular vesicles mediate stem cell signaling and systemic RNAi in planarians tmp: image: /images/cc_by_nc.png legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) short: CC BY-NC (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21707' abstract: - lang: eng text: Structural and functional differences between brain hemispheres are a common feature of animal nervous systems with reduced bilateral asymmetry often linked to impaired cognitive performance. How neuronal left-right asymmetry is initiated and integrated into a bilaterally symmetrical ground pattern is poorly understood. Here, we show that the directional asymmetry of a Drosophila central brain circuit originates from axonal interactions of two types of bilateral pioneer neurons. Subsequent recruitment of neighboring neurons into the asymmetric neuropil primordium results in hemisphere-specific microcircuits. Circuit lateralization requires dynamic expression of the cell adhesion molecule Fasciclin 2 to maintain structural plasticity in axonal remodeling. Reduced circuit asymmetry following cell type–specific Fasciclin 2 manipulation affects adult brain function. These results reveal an unexpected degree of developmental plasticity of late-born Drosophila neurons in the formation of a circuit node via the lateralized recruitment of symmetric circuit components. acknowledgement: "We thank I. Salecker (Flybow), B. Altenhein (Fas2-Gal4Mz507), A. Nose (UAS-intra- and extra-Fas2::YFP), and C. S. Goodman (UAS-Fas2PEST+/−), as well as the Bloomington Stock Center for providing materials and fly stocks. We thank S. Waddell and the lab, especially B. Senapati, for providing the opportunity to conduct memory experiments at the CNCB, University of Oxford, and for supervision and discussions during this period. We also thank W. Kallina, S. Ilgerl, D. Bartel, A. Grimm, and A. Litin for technical support and the Hummel Lab for stimulating discussions and critical comments on the manuscript. We acknowledge the early exploratory work of A. Mattia, S. Trkulja, C. Schönherr, S. Bogner, B. Simpson, L. Tomasek, H. Roth, H. Vokač, R. Gredler, F. Kapelari, T. Kolarova, C. Ignitsch, Á. Bautista-Soldevila, and M. Kassem.\r\nThis research was funded by the University of Vienna, the Vienna Doctoral School Cognition, Behaviour and Neuroscience (uni:docs fellowship) (to J.W.M.) and by the Austrian Science Fund (FWF) (Cluster of Excellence Neuronal Circuits in Health and Disease, grant DOI 10.55776/COE16; https://www.fwf.ac.at/en/research-radar/10.55776/COE16) (to T.H.). For open access purposes, the author has applied a CC BY public copyright license to any author-accepted manuscript version arising from this submission." article_number: eaea6020 article_processing_charge: Yes article_type: original author: - first_name: Johann W. full_name: Markovitsch, Johann W. last_name: Markovitsch - first_name: Daniel full_name: Mitić, Daniel last_name: Mitić - first_name: Alisa full_name: Del Pilar Jiménez García, Alisa last_name: Del Pilar Jiménez García - first_name: Alsberga full_name: Zane, Alsberga id: 60f7509a-f652-11ea-9d86-b963d6490d7c last_name: Zane orcid: 0009-0003-0415-7603 - first_name: Sarah full_name: Kainz, Sarah last_name: Kainz - first_name: Rashmit full_name: Kaur, Rashmit last_name: Kaur - first_name: Thomas full_name: Hummel, Thomas last_name: Hummel citation: ama: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, et al. Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity. Science Advances. 2026;12(13). doi:10.1126/sciadv.aea6020 apa: Markovitsch, J. W., Mitić, D., Del Pilar Jiménez García, A., Zane, A., Kainz, S., Kaur, R., & Hummel, T. (2026). Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity. Science Advances. AAAS. https://doi.org/10.1126/sciadv.aea6020 chicago: Markovitsch, Johann W., Daniel Mitić, Alisa Del Pilar Jiménez García, Alsberga Zane, Sarah Kainz, Rashmit Kaur, and Thomas Hummel. “Sequential Formation of Drosophila Circuit Asymmetry via Prolonged Structural Plasticity.” Science Advances. AAAS, 2026. https://doi.org/10.1126/sciadv.aea6020. ieee: J. W. Markovitsch et al., “Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity,” Science Advances, vol. 12, no. 13. AAAS, 2026. ista: Markovitsch JW, Mitić D, Del Pilar Jiménez García A, Zane A, Kainz S, Kaur R, Hummel T. 2026. Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity. Science Advances. 12(13), eaea6020. mla: Markovitsch, Johann W., et al. “Sequential Formation of Drosophila Circuit Asymmetry via Prolonged Structural Plasticity.” Science Advances, vol. 12, no. 13, eaea6020, AAAS, 2026, doi:10.1126/sciadv.aea6020. short: J.W. Markovitsch, D. Mitić, A. Del Pilar Jiménez García, A. Zane, S. Kainz, R. Kaur, T. Hummel, Science Advances 12 (2026). date_created: 2026-04-12T22:01:48Z date_published: 2026-03-27T00:00:00Z date_updated: 2026-10-20T08:11:29Z day: '27' ddc: - '570' department: - _id: MiSi - _id: GradSch doi: 10.1126/sciadv.aea6020 file: - access_level: open_access checksum: 3eed470fe73e53d2a8d55d6fba6934e3 content_type: application/pdf creator: dernst date_created: 2026-05-04T09:16:36Z date_updated: 2026-05-04T09:16:36Z file_id: '21786' file_name: 2026_ScienceAdv_Markovitsch.pdf file_size: 11101140 relation: main_file success: 1 file_date_updated: 2026-05-04T09:16:36Z fulldoi: https://doi.org/10.1126/sciadv.aea6020 has_accepted_license: '1' intvolume: ' 12' issue: '13' language: - iso: eng month: '03' oa: 1 oa_version: Published Version publication: Science Advances publication_identifier: eissn: - 2375-2548 publication_status: published publisher: AAAS quality_controlled: '1' scopus_import: '1' status: public title: Sequential formation of Drosophila circuit asymmetry via prolonged structural plasticity tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 12 year: '2026' ... --- OA_type: closed access _id: '22315' abstract: - lang: eng text: Plant tropisms enable roots to navigate complex soils by responding to directional environmental cues. Biological decay, although central to nutrient cycling, also creates microbially active and potentially hostile niches. In this work, we identified “saprotropism,” a previously unrecognized growth response that enables roots to actively bend away from decaying plant-derived matter. Fungal-driven microbial decomposition released organic acids and formed stable pH gradients in surrounding soil, allowing roots to pinpoint decay without direct contact. Root epidermal cells sensed this acidic gradient through the root meristem growth factor peptide-receptor module, converting external pH asymmetry into asymmetric abscisic acid (ABA) distribution. ABA asymmetry drove microtubule reorganization, which was decoded into decay-avoidant root bending. Together, these findings establish microbial decay–derived chemical gradients as an instructive signal for root navigation and expand the framework of microbe-soil-plant communication. acknowledgement: 'We are grateful to H. Guo and L. Liu (Department of Biology, Southern University of Science and Technology) for providing the rgf1/2/3, rgi1/2/3/4, tpst-1, and pepr1/2 lines. We thank K.-h. Liu (College of Life Science, Northwest A&F University) for generously providing the ABA biosensor nlsABACUS2-400n. We also thank J. Li and J. Chang (School of Life Sciences, Lanzhou University) for providing the ahk2-5/cre1-2, ahp1/2/3, arr16/arr17, and pTCSn::GFP lines. Our thanks further extend to D. Qian, also from the School of Life Sciences at Lanzhou University, for sharing Arabidopsis line pTUB6::mCherry-TUB6. We are grateful to Y. Zhao (CAS Center for Excellence in Molecular Plant Sciences, Chinese Academy of Sciences) for providing nced3/5, snrk2.2/2.3/2.6, and pyl duodecuple mutants. We also acknowledge the Teaching and Research Core Facility at the College of Life Sciences, Northwest A&F University, particularly N. Fan, for their invaluable technical assistance. We also thank Life Science Research Core Services (LSRCS), Northwest A&F University, for helping with characterization, including CLSM (X. Liu). Fundamental and Interdisciplinary Disciplines Breakthrough Plan of the Ministry of Education of China JYB2025XDXM706 (Y.Z.); Qin Chuangyuan High-level Innovation and Entrepreneurship Talent Program QCYRCXM-2022-237 (Y.Z.); Fundamental Research Funds for the Central Universities K20200168 (Y.Z.); National Natural Science Foundation of China 32570375 (Y.Z.); National Natural Science Foundation of China 32400699 (A.Z.); European Research Council (ERC, CYNIPS) 101142681 (J.F.); Austrian Science Fund (FWF): P 37051-B (J.F.).' article_number: eadw6568 article_processing_charge: No article_type: original author: - first_name: Zhulatai full_name: Bao, Zhulatai last_name: Bao - first_name: Huihui full_name: Wang, Huihui last_name: Wang - first_name: Ai full_name: Zhang, Ai last_name: Zhang - first_name: Ruxi full_name: Gao, Ruxi last_name: Gao - first_name: Wen full_name: Gu, Wen last_name: Gu - first_name: Ni full_name: Fan, Ni last_name: Fan - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 - first_name: Yuzhou full_name: Zhang, Yuzhou last_name: Zhang citation: ama: Bao Z, Wang H, Zhang A, et al. Roots navigate around decay regions by sensing local pH gradients. Science. 2026;393(6807). doi:10.1126/science.adw6568 apa: Bao, Z., Wang, H., Zhang, A., Gao, R., Gu, W., Fan, N., … Zhang, Y. (2026). Roots navigate around decay regions by sensing local pH gradients. Science. AAAS. https://doi.org/10.1126/science.adw6568 chicago: Bao, Zhulatai, Huihui Wang, Ai Zhang, Ruxi Gao, Wen Gu, Ni Fan, Jiří Friml, and Yuzhou Zhang. “Roots Navigate around Decay Regions by Sensing Local PH Gradients.” Science. AAAS, 2026. https://doi.org/10.1126/science.adw6568. ieee: Z. Bao et al., “Roots navigate around decay regions by sensing local pH gradients,” Science, vol. 393, no. 6807. AAAS, 2026. ista: Bao Z, Wang H, Zhang A, Gao R, Gu W, Fan N, Friml J, Zhang Y. 2026. Roots navigate around decay regions by sensing local pH gradients. Science. 393(6807), eadw6568. mla: Bao, Zhulatai, et al. “Roots Navigate around Decay Regions by Sensing Local PH Gradients.” Science, vol. 393, no. 6807, eadw6568, AAAS, 2026, doi:10.1126/science.adw6568. short: Z. Bao, H. Wang, A. Zhang, R. Gao, W. Gu, N. Fan, J. Friml, Y. Zhang, Science 393 (2026). das_tickbox: '1' dataavailabilitystatement: All data are available in the manuscript or the supplementary materials. The raw RNA-seq data have been deposited in the NCBI Gene Expression Omnibus (GEO) under accession number GSE315473. Microbiome sequencing data have been deposited in the Sequence Read Archive (SRA) under BioProject number PRJNA1397137. Materials are available upon request from the corresponding author. date_created: 2026-07-13T14:57:10Z date_published: 2026-07-09T00:00:00Z date_updated: 2026-10-20T08:12:03Z day: '09' department: - _id: JiFr doi: 10.1126/science.adw6568 external_id: pmid: - '42424472' fulldoi: https://doi.org/10.1126/science.adw6568 intvolume: ' 393' issue: '6807' language: - iso: eng month: '07' oa_version: None pmid: 1 project: - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants - _id: 7bcece63-9f16-11ee-852c-ae94e099eeb6 grant_number: P37051 name: Guanylate cyclase activity of TIR1/AFBs auxin receptors publication: Science publication_identifier: eissn: - 1095-9203 issn: - 0036-8075 publication_status: published publisher: AAAS quality_controlled: '1' related_material: link: - description: News on ISTA website relation: press_release url: https://ista.ac.at/en/news/roots-steer-clear-of-plant-rot/ researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: yes title: Roots navigate around decay regions by sensing local pH gradients type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 393 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '23044' abstract: - lang: eng text: We report the discovery of 31 new high-z quasars in the redshift range 6.6 < z < 7.8. These quasars were selected from approximately 3000 deg2 of sky covered during the first 1.5 years of the Euclid Wide Survey, representing the initial results of the Euclid high-z quasar search. Our candidate selection employed multiple machine-learning and probabilistic techniques applied to the EuclidIE, YE, JE, and HE images, supplemented by ancillary z-band data when available. Spectroscopic follow-up observations were carried out with Keck, Magellan, and the Large Binocular Telescope (LBT). Among the new discoveries, there are 12 quasars at z ≥ 7, more than doubling the number of previously known quasars at z ≥ 7. The newly discovered quasars exhibit 21.2 < JE < 23.2 (−25.5 < M1450 < −23.6), extending quasar studies to the faint end of the quasar luminosity function (QLF) at z ≳ 7. The quasar with the highest-z, EUCL J172902.75+641018.1 at z ≈ 7.77, sets the new redshift record for the most distant quasar ever reported. These discoveries demonstrate Euclid’s transformative role in high-z quasar discovery and set the stage for future follow-up studies of the early galaxies hosting quasars, supermassive black hole growth, and the intergalactic medium in the epoch of reionisation. acknowledgement: 'D. Yang acknowledges helpful discussions with members of the ENIGMA group at UC Santa Barbara and Leiden University, in particular Elia Pizzati, Silvia Onorato, and Diego González for their valuable feedback. D. Yang thanks Shane Bechtel for assistance during observations, and acknowledges the early contributions of Riccardo Nanni, which helped lay the foundation for this work. D. Yang and J. F. Hennawi acknowledge support from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement No 885301). J. F. Hennawi acknowledges support from NSF grant No. 2307180. F. Guarneri and J.-T. Schindler are supported by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) – Project number 518006966. F. Wang acknowledges support from NSF award AST-2513040. R. Decarli acknowledges support from the INAF GO 2022 grant “The birth of the giants: JWST sheds light on the build-up of quasars at cosmic dawn”, INAF Minigrant 2024 “The interstellar medium at high redshift”, and by the PRIN MUR “2022935STW”, RFF M4.C2.1.1, CUP J53D23001570006 and C53D23000950006. S. E. I. Bosman is supported by the Deutsche Forschungsgemeinschaft (DFG) under Emmy Noether grant number BO 5771/1-1. Y. Harikane acknowledges support from the Japan Society for the Promotion of Science (JSPS) Grant-in-Aid for Scientific Research (24H00245), the JSPS Core-to-Core Program (JPJSCCA20210003), and the JSPS International Leading Research (22K21349). J. R. Weaver acknowledges that support for this work was provided by The Brinson Foundation through a Brinson Prize Fellowship grant. The Euclid Consortium acknowledges the European Space Agency and a number of agencies and institutes that have supported the development of Euclid, in particular the Agenzia Spaziale Italiana, the Austrian Forschungsförderungsgesellschaft funded through BMIMI, the Belgian Science Policy, the Canadian Euclid Consortium, the Deutsches Zentrum für Luft- und Raumfahrt, the DTU Space and the Niels Bohr Institute in Denmark, the French Centre National d’Etudes Spatiales, the Fundação para a Ciência e a Tecnologia, the Hungarian Academy of Sciences, the Ministerio de Ciencia, Innovación y Universidades, the National Aeronautics and Space Administration, the National Astronomical Observatory of Japan, the Netherlandse Onderzoekschool Voor Astronomie, the Norwegian Space Agency, the Research Council of Finland, the Romanian Space Agency, the State Secretariat for Education, Research, and Innovation (SERI) at the Swiss Space Office (SSO), and the United Kingdom Space Agency. A complete and detailed list is available on the Euclid web site (www.euclid-ec.org). Some of the data presented herein were obtained at Keck Observatory, which is a private 501(c)3 non-profit organization operated as a scientific partnership among the California Institute of Technology, the University of California, and the National Aeronautics and Space Administration. The Observatory was made possible by the generous financial support of the W. M. Keck Foundation. The authors wish to recognise and acknowledge the very significant cultural role and reverence that the summit of Maunakea has always had within the Native Hawaiian community. We are most fortunate to have the opportunity to conduct observations from this mountain. This paper includes data gathered with the 6.5 meter Magellan Telescopes located at Las Campanas Observatory, Chile. This work uses LBT data from programmes: MPIA-2025A-007 and MPIA-2025B-004. The LBT is an international collaboration among institutions in the United States, Italy and Germany. LBT Corporation partners are: The University of Arizona on behalf of the Arizona university system; Istituto Nazionale di Astrofisica, Italy; LBT Beteiligungsgesellschaft, Germany, representing the Max-Planck Society, the Astrophysical Institute Potsdam, and Heidelberg University; The Ohio State University, and The Research Corporation, on behalf of The University of Notre Dame, University of Minnesota, and University of Virginia, LOFAR data products were provided by the LOFAR Surveys Key Science project (LSKSP; https://lofar-surveys.org/) and were derived from observations with the International LOFAR Telescope (ILT). LOFAR is the Low Frequency Array designed and constructed by ASTRON. It has observing, data processing, and data storage facilities in several countries, which are owned by various parties (each with their own funding sources), and which are collectively operated by the ILT foundation under a joint scientific policy. The efforts of the LSKSP have benefited from funding from the European Research Council, NOVA, NWO, CNRS-INSU, the SURF Co-operative, the UK Science and Technology Funding Council and the Jülich Supercomputing Centre. We make use of z-band imaging from the Wide Imaging with Subaru HSC of the Euclid Sky (WISHES) program operated by the Subaru Telescope, which is operated by the National Astronomical Observatory of Japan. We also make use of z-band imaging from the Dark Energy Survey (DES), based on observations obtained at the Cerro Tololo Inter-American Observatory, National Optical Astronomy Observatory, which is operated by AURA under a cooperative agreement with the National Science Foundation. This work made use of NumPy (Harris et al. 2020), SciPy (Virtanen et al. 2020), Astropy (Astropy Collaboration 2013, 2018, 2022), PypeIt (Prochaska et al. 2020), Sculptor (Schindler 2022), condXD (Kang et al. 2025), pysersic (Pasha & Miller 2023), Matplotlib (Hunter 2007), corner.py (Foreman-Mackey 2016), healpy (Zonca et al. 2020).' article_number: A104 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: D. full_name: Yang, D. last_name: Yang - first_name: J. F. full_name: Hennawi, J. F. last_name: Hennawi - first_name: F. full_name: Guarneri, F. last_name: Guarneri - first_name: J. full_name: Wolf, J. last_name: Wolf - first_name: S. full_name: Belladitta, S. last_name: Belladitta - first_name: J. T. full_name: Schindler, J. T. last_name: Schindler - first_name: A. C.N. full_name: Hughes, A. C.N. last_name: Hughes - first_name: E. full_name: Bañados, E. last_name: Bañados - first_name: D. J. full_name: Mortlock, D. 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W. last_name: Rix - first_name: E. full_name: Romelli, E. last_name: Romelli - first_name: M. full_name: Roncarelli, M. last_name: Roncarelli - first_name: C. full_name: Rosset, C. last_name: Rosset - first_name: B. full_name: Rusholme, B. last_name: Rusholme - first_name: R. full_name: Saglia, R. last_name: Saglia - first_name: Z. full_name: Sakr, Z. last_name: Sakr - first_name: D. full_name: Sapone, D. last_name: Sapone - first_name: M. full_name: Sauvage, M. last_name: Sauvage - first_name: M. full_name: Schirmer, M. last_name: Schirmer - first_name: P. full_name: Schneider, P. last_name: Schneider - first_name: T. full_name: Schrabback, T. last_name: Schrabback - first_name: A. full_name: Secroun, A. last_name: Secroun - first_name: G. full_name: Seidel, G. last_name: Seidel - first_name: S. full_name: Serrano, S. last_name: Serrano - first_name: E. full_name: Sihvola, E. last_name: Sihvola - first_name: P. full_name: Simon, P. last_name: Simon - first_name: C. full_name: Sirignano, C. last_name: Sirignano - first_name: G. full_name: Sirri, G. last_name: Sirri - first_name: L. full_name: Stanco, L. last_name: Stanco - first_name: J. full_name: Steinwagner, J. last_name: Steinwagner - first_name: P. full_name: Tallada-Crespí, P. last_name: Tallada-Crespí - first_name: I. full_name: Tereno, I. last_name: Tereno - first_name: N. full_name: Tessore, N. last_name: Tessore - first_name: S. full_name: Toft, S. last_name: Toft - first_name: R. full_name: Toledo-Moreo, R. last_name: Toledo-Moreo - first_name: F. full_name: Torradeflot, F. last_name: Torradeflot - first_name: I. full_name: Tutusaus, I. last_name: Tutusaus - first_name: L. full_name: Valenziano, L. last_name: Valenziano - first_name: J. full_name: Valiviita, J. last_name: Valiviita - first_name: T. full_name: Vassallo, T. last_name: Vassallo - first_name: Y. full_name: Wang, Y. last_name: Wang - first_name: J. full_name: Weller, J. last_name: Weller - first_name: F. M. full_name: Zerbi, F. M. last_name: Zerbi - first_name: E. full_name: Zucca, E. last_name: Zucca - first_name: G. full_name: Fabbian, G. last_name: Fabbian - first_name: M. full_name: Huertas-Company, M. last_name: Huertas-Company - first_name: J. full_name: Martín-Fleitas, J. last_name: Martín-Fleitas - first_name: P. full_name: Monaco, P. last_name: Monaco - first_name: V. full_name: Scottez, V. last_name: Scottez - first_name: M. full_name: Viel, M. last_name: Viel citation: ama: 'Yang D, Hennawi JF, Guarneri F, et al. Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8. Astronomy & Astrophysics. 2026;711. doi:10.1051/0004-6361/202658883' apa: 'Yang, D., Hennawi, J. F., Guarneri, F., Wolf, J., Belladitta, S., Schindler, J. T., … Viel, M. (2026). Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202658883' chicago: 'Yang, D., J. F. Hennawi, F. Guarneri, J. Wolf, S. Belladitta, J. T. Schindler, A. C.N. Hughes, et al. “Euclid: Discovery of 31 New Quasars at 6.6 < z < 7.8.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202658883.' ieee: 'D. Yang et al., “Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8,” Astronomy & Astrophysics, vol. 711. EDP Sciences, 2026.' ista: 'Yang D et al. 2026. Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8. Astronomy & Astrophysics. 711, A104.' mla: 'Yang, D., et al. “Euclid: Discovery of 31 New Quasars at 6.6 < z < 7.8.” Astronomy & Astrophysics, vol. 711, A104, EDP Sciences, 2026, doi:10.1051/0004-6361/202658883.' short: D. Yang, J.F. Hennawi, F. Guarneri, J. Wolf, S. Belladitta, J.T. Schindler, A.C.N. Hughes, E. Bañados, D.J. Mortlock, J. Yang, F. Wang, X. Fan, K. Jahnke, D. Stern, C.J. Willott, A.J. Barth, H.J.A. Rottgering, R.G. Varadaraj, R. Decarli, A.C. Eilers, M. Ezziati, Y. Fu, J. Huang, X. Jin, Y. Kang, L.N. Martinez-Ramirez, Y. Matsuoka, M. Onoue, R. Pello, R.P. Remigio, W.L. Tee, B. Venemans, G. Vietri, B. Wang, L.J. Abbo, H. Atek, S. Bisogni, S.E.I. Bosman, R.A.A. Bowler, C.J. Conselice, F.B. Davies, C.M. Gutierrez, Y. Harikane, K. Rubinur, C.C. Lovell, M. Magliocchetti, J.J. Matthee, F. Ricci, M. Scialpi, D. Scott, L. Spinoglio, F. Tarsitano, Y. Toba, F. Walter, J.R. Weaver, G. Zamorani, B. Altieri, A. Amara, S. Andreon, H. Aussel, C. Baccigalupi, M. Baldi, A. Balestra, S. Bardelli, P. Battaglia, A. Biviano, E. Branchini, M. Brescia, S. Camera, G. Cañas-Herrera, V. Capobianco, C. Carbone, J. Carretero, M. Castellano, G. Castignani, S. Cavuoti, K.C. Chambers, A. Cimatti, C. Colodro-Conde, G. Congedo, L. Conversi, Y. Copin, F. Courbin, H.M. Courtois, M. Cropper, J.C. Cuillandre, H. Degaudenzi, G. De Lucia, C. Dolding, H. Dole, M. Douspis, F. Dubath, X. Dupac, S. Dusini, S. Escoffier, M. Farina, R. Farinelli, S. Ferriol, F. Finelli, N. Fourmanoit, M. Frailis, E. Franceschi, M. Fumana, S. Galeotta, K. George, B. Gillis, C. Giocoli, P. Gómez-Alvarez, J. Gracia-Carpio, A. Grazian, F. Grupp, L. Guzzo, S. Gwyn, S.V.H. Haugan, H. Hoekstra, W. Holmes, I.M. Hook, F. Hormuth, A. Hornstrup, M. Jhabvala, S. Kermiche, B. Kubik, K. Kuijken, M. Kümmel, M. Kunz, H. Kurki-Suonio, A.M.C. Le Brun, S. Ligori, P.B. Lilje, V. Lindholm, I. Lloro, G. Mainetti, D. Maino, E. Maiorano, O. Mansutti, O. Marggraf, M. Martinelli, N. Martinet, F. Marulli, R.J. Massey, H.J. Mccracken, E. Medinaceli, S. Mei, Y. Mellier, M. Meneghetti, E. Merlin, G. Meylan, J.J. Mohr, A. Mora, M. Moresco, L. Moscardini, E. Munari, R. Nakajima, C. Neissner, R.C. Nichol, S.M. Niemi, C. Padilla, S. Paltani, F. Pasian, K. Pedersen, W.J. Percival, V. Pettorino, S. Pires, G. Polenta, M. Poncet, L.A. Popa, L. Pozzetti, G.D. Racca, F. Raison, R. Rebolo, A. Renzi, J. Rhodes, G. Riccio, H.W. Rix, E. Romelli, M. Roncarelli, C. Rosset, B. Rusholme, R. Saglia, Z. Sakr, D. Sapone, M. Sauvage, M. Schirmer, P. Schneider, T. Schrabback, A. Secroun, G. Seidel, S. Serrano, E. Sihvola, P. Simon, C. Sirignano, G. Sirri, L. Stanco, J. Steinwagner, P. Tallada-Crespí, I. Tereno, N. Tessore, S. Toft, R. Toledo-Moreo, F. Torradeflot, I. Tutusaus, L. Valenziano, J. Valiviita, T. Vassallo, Y. Wang, J. Weller, F.M. Zerbi, E. Zucca, G. Fabbian, M. Huertas-Company, J. Martín-Fleitas, P. Monaco, V. Scottez, M. Viel, Astronomy & Astrophysics 711 (2026). das_tickbox: '1' dataavailabilitystatement: This work has made use of Euclid data from the European Space Agency (ESA) mission Euclid. The quasar cutouts are available at https://doi.org/10.57780/esa-50769fd. The discovery spectra are available from the corresponding author upon reasonable request. date_created: 2026-10-04T22:01:54Z date_published: 2026-07-01T00:00:00Z date_updated: 2026-10-20T08:15:12Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.1051/0004-6361/202658883 external_id: arxiv: - '2607.03432' file: - access_level: open_access checksum: 055c80a2cd071884e2804ef17dcf1e16 content_type: application/pdf creator: dernst date_created: 2026-10-12T06:20:29Z date_updated: 2026-10-12T06:20:29Z file_id: '23097' file_name: 2026_AstronomyAstrophysics_Yang.pdf file_size: 14151909 relation: main_file success: 1 file_date_updated: 2026-10-12T06:20:29Z fulldoi: https://doi.org/10.1051/0004-6361/202658883 has_accepted_license: '1' intvolume: ' 711' language: - iso: eng month: '07' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: 'Euclid: Discovery of 31 new quasars at 6.6 < z < 7.8' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 711 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '23049' abstract: - lang: eng text: 'We investigate the properties of extreme emission line galaxies (EELGs) at z = 4 − 9 and their role in reionization. Compact, low-mass galaxies with intense optical emission lines are linked to elevated specific star formation rates (sSFRs) and recent bursts of star formation. Feedback in these systems may enable the leakage of ionizing radiation into the intergalactic medium. Using JWST/NIRSpec spectroscopy from the CAPERS, CEERS, and RUBIES surveys, we compiled 160 NIRCam-selected EELGs in the EGS field. These galaxies show extreme rest-frame equivalent widths (EWs), with a median EW([O III]+Hβ) = 1616 Å and EW(Hα) = 763 Å. They are low-mass (median log(M★/M⊙) = 8.26) with high sSFRs (median 43 Gyr−1), above the z ∼ 6 main sequence. UV slopes are diverse, with a median value of β = −2.0, and only 7% have extremely blue continua (β < −2.6). Emission-line diagnostics suggest stellar populations as the primary ionizing source, although an AGN fraction of 14% cannot be entirely ruled out. These galaxies are efficient ionizing photon producers, with median log(ξion [Hz erg−1]) = 25.37, exceeding typical values at similar redshifts. Escape fractions, however, are heterogeneous: 16% of EELGs at z < 7 show escape fractions > 5% for both Lyα and LyC photons, while 82% lack detectable Lyα emission. The median inferred LyC escape fraction is modest (5%) but enhanced in compact super-Eddington systems with sSFR > 25 Gyr−1. These results indicate that EELGs contribute approximately 16 − 40% of the total ionizing emissivity required to sustain hydrogen reionization. EELGs are extremely compact, with a median effective radius of 0.49 kpc, and exhibit a recent star formation burst. Our analysis indicates that sSFR and star formation rate surface density are the primary drivers of their extreme emission line strengths.' acknowledgement: 'We thank the anonymous referee for the thorough review and constructive suggestions that significantly improved this paper. We also thank Sophia Flury for valuable feedback and insightful comments, which helped refine our interpretation of the results. MLl acknowledges support from the INAF Large Grant 2022 “Extragalactic Surveys with JWST” (PI L. Pentericci), the PRIN 2022 MUR project 2022CB3PJ3 – First Light And Galaxy aSsembly (FLAGS) funded by the European Union – Next Generation EU, the INAF Mini-grant 2024 “Galaxies in the epoch of Reionization and their analogs at lower redshift” (PI M. Llerena), and the Large Grant RF 2023 F.O. 1.05.23.01.11 “The MOONS Extragalactic Survey”. RA acknowledges support of Grant PID2023-147386NB-I00 funded by MICIU/AEI/10.13039/501100011033 and by ERDF/EU, and the Severo Ochoa award to the IAA-CSIC CEX2021-001131-S. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-03127. Support for program number GO-6368 was provided through a grant from the STScI under NASA contract NAS5-03127. The data were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute. These observations are associated with program #6368, and can be accessed via doi. Some of the data products presented herein were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation under grant DNRF140. These observations are associated with programs #1345, #2750, and #4233. This work has made extensive use of Python packages astropy (Astropy Collaboration 2018), numpy (Harris et al. 2020), Matplotlib (Hunter 2007) and LiMe (Fernández et al. 2024).' article_number: A152 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: M. full_name: Llerena, M. last_name: Llerena - first_name: L. full_name: Pentericci, L. last_name: Pentericci - first_name: R. full_name: Amorín, R. last_name: Amorín - first_name: A. full_name: Ferrara, A. last_name: Ferrara - first_name: M. full_name: Dickinson, M. last_name: Dickinson - first_name: F. full_name: Arevalo-Gonzalez, F. last_name: Arevalo-Gonzalez - first_name: A. full_name: Calabrò, A. last_name: Calabrò - first_name: L. full_name: Napolitano, L. last_name: Napolitano - first_name: Sara full_name: Mascia, Sara id: edaf889c-c7cd-11ef-ab1b-bb28c431bd29 last_name: Mascia - first_name: P. full_name: Arrabal Haro, P. last_name: Arrabal Haro - first_name: R. full_name: Begley, R. last_name: Begley - first_name: N. J. full_name: Cleri, N. J. last_name: Cleri - first_name: K. full_name: Davis, K. last_name: Davis - first_name: W. full_name: Hu, W. last_name: Hu - first_name: J. S. full_name: Kartaltepe, J. S. last_name: Kartaltepe - first_name: A. M. full_name: Koekemoer, A. M. last_name: Koekemoer - first_name: R. A. full_name: Lucas, R. A. last_name: Lucas - first_name: E. full_name: Mcgrath, E. last_name: Mcgrath - first_name: D. J. full_name: Mcleod, D. J. last_name: Mcleod - first_name: C. full_name: Papovich, C. last_name: Papovich - first_name: T. M. full_name: Stanton, T. M. last_name: Stanton - first_name: A. J. full_name: Taylor, A. J. last_name: Taylor - first_name: R. full_name: Tripodi, R. last_name: Tripodi - first_name: X. full_name: Wang, X. last_name: Wang - first_name: L. Y.A. full_name: Yung, L. Y.A. last_name: Yung citation: ama: 'Llerena M, Pentericci L, Amorín R, et al. Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202557897' apa: 'Llerena, M., Pentericci, L., Amorín, R., Ferrara, A., Dickinson, M., Arevalo-Gonzalez, F., … Yung, L. Y. A. (2026). Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202557897' chicago: 'Llerena, M., L. Pentericci, R. Amorín, A. Ferrara, M. Dickinson, F. Arevalo-Gonzalez, A. Calabrò, et al. “Extreme Equivalent-Width-Selected Low-Mass Starbursts at z = 4 − 9: Insights into Their Role in Cosmic Reionization.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202557897.' ieee: 'M. Llerena et al., “Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.' ista: 'Llerena M, Pentericci L, Amorín R, Ferrara A, Dickinson M, Arevalo-Gonzalez F, Calabrò A, Napolitano L, Mascia S, Arrabal Haro P, Begley R, Cleri NJ, Davis K, Hu W, Kartaltepe JS, Koekemoer AM, Lucas RA, Mcgrath E, Mcleod DJ, Papovich C, Stanton TM, Taylor AJ, Tripodi R, Wang X, Yung LYA. 2026. Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization. Astronomy & Astrophysics. 708, A152.' mla: 'Llerena, M., et al. “Extreme Equivalent-Width-Selected Low-Mass Starbursts at z = 4 − 9: Insights into Their Role in Cosmic Reionization.” Astronomy & Astrophysics, vol. 708, A152, EDP Sciences, 2026, doi:10.1051/0004-6361/202557897.' short: M. Llerena, L. Pentericci, R. Amorín, A. Ferrara, M. Dickinson, F. Arevalo-Gonzalez, A. Calabrò, L. Napolitano, S. Mascia, P. Arrabal Haro, R. Begley, N.J. Cleri, K. Davis, W. Hu, J.S. Kartaltepe, A.M. Koekemoer, R.A. Lucas, E. Mcgrath, D.J. Mcleod, C. Papovich, T.M. Stanton, A.J. Taylor, R. Tripodi, X. Wang, L.Y.A. Yung, Astronomy & Astrophysics 708 (2026). das_tickbox: '1' dataavailabilitystatement: Table A.1 is available at the CDS via https://cdsarc.cds.unistra.fr/viz-bin/cat/J/A+A/708/A152 date_created: 2026-10-04T22:01:55Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-10-20T08:15:59Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.1051/0004-6361/202557897 external_id: arxiv: - '2510.25647' file: - access_level: open_access checksum: d678534203385bec7579e68e12cc09b4 content_type: application/pdf creator: dernst date_created: 2026-10-12T07:19:26Z date_updated: 2026-10-12T07:19:26Z file_id: '23100' file_name: 2026_AstronomyAstrophysics_Llerena.pdf file_size: 5918938 relation: main_file success: 1 file_date_updated: 2026-10-12T07:19:26Z fulldoi: https://doi.org/10.1051/0004-6361/202557897 has_accepted_license: '1' intvolume: ' 708' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: 'Extreme equivalent-width-selected low-mass starbursts at z = 4 − 9: Insights into their role in cosmic reionization' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 708 year: '2026' ... --- OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '23050' abstract: - lang: eng text: The resonant scattering nature of Lyα photons interacting with neutral hydrogen makes Lyα emitters (LAEs) robust tracers of the intergalactic neutral hydrogen fraction, and thus sensitive probes of cosmic reionization. We present an extensive study of the Lyα evolution from galaxies at 4.5 ≤ z ≤ 11 in the UDS field, observed as part of the CAPERS survey, and complemented with spectra from the DAWN JWST Archive. The combined sample includes 651 spectroscopically confirmed Lyα-break galaxies, among which we find 73 S/N > 3 LAEs in JWST-NIRSpec PRISM spectra. We trace the redshift evolution of the LAE fraction with EW0 > 25 Å (XLyα) between z = 5 and z = 9, extending such an analysis to the UDS field for the first time. At z = 5 and 6, the UDS results agree with the average JWST XLyα values from multiple fields. However, JWST measurements are consistently lower than ground-based results. To investigate this, we compare JWST observations to a population of star-forming galaxies at z ∼ 6 observed with VLT-FORS2. We find that a Lyα slit-loss of 35 ± 10% in JWST spectra accounts for the offset, as the resonant Lyα emission is more spatially extended than the stellar continuum. From z = 6 to 7, the UDS field shows a significant drop in Lyα visibility, from which we infer a neutral hydrogen fraction of XHI = 0.7–0.9. Finally, we identify two robust ionized bubbles at z = 7.29 and 7.77, with radii of Rion = 0.6 and 0.5 physical Mpc and photometric overdensities of N/⟨N⟩ = 3 and 4, based on candidate counts down to the photometric completeness limit. Compared to the large ionized region at z ∼ 7 in the EGS field, these results indicate significant field-to-field variation, supporting a patchy, inhomogeneous reionization process. acknowledgement: 'We thank the anonymous referee for the constructive feedback provided. LN acknowledges support from grant “Progetti per Avvio alla Ricerca – Tipo 1, Unveiling Cosmic Dawn: Galaxy Evolution with CAPERS” (AR1241906F947685) and from PRIN 2022 MUR project 2022CB3PJ3 – First Light And Galaxy aSsembly (FLAGS) funded by the European Union – Next Generation EU. LN, LP, AB, and BC acknowledge support from the ERC synergy grant 101166930 – RECAP. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope, obtained at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-03127. These observations are associated with programs #6368, #4233, #1215, #2565, and #3543. Support for program number GO-6368 was provided through a grant from the STScI under NASA contract NAS5-03127. The data were obtained from the Mikulski Archive for Space Telescopes (MAST) at the Space Telescope Science Institute. These observations can be accessed via DOI. Some of the data products presented in this work were retrieved from the Dawn JWST Archive (DJA). DJA is an initiative of the Cosmic Dawn Center (DAWN), which is funded by the Danish National Research Foundation under grant DNRF140.' article_number: A102 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: L. full_name: Napolitano, L. last_name: Napolitano - first_name: L. full_name: Pentericci, L. last_name: Pentericci - first_name: M. full_name: Dickinson, M. last_name: Dickinson - first_name: P. full_name: Arrabal Haro, P. last_name: Arrabal Haro - first_name: A. J. full_name: Taylor, A. J. last_name: Taylor - first_name: A. full_name: Calabrò, A. last_name: Calabrò - first_name: A. full_name: Bhagwat, A. last_name: Bhagwat - first_name: P. full_name: Santini, P. last_name: Santini - first_name: F. full_name: Arevalo-Gonzalez, F. last_name: Arevalo-Gonzalez - first_name: R. full_name: Begley, R. last_name: Begley - first_name: M. full_name: Castellano, M. last_name: Castellano - first_name: B. full_name: Ciardi, B. last_name: Ciardi - first_name: C. T. full_name: Donnan, C. T. last_name: Donnan - first_name: D. full_name: Dottorini, D. last_name: Dottorini - first_name: J. S. full_name: Dunlop, J. S. last_name: Dunlop - first_name: S. L. full_name: Finkelstein, S. L. last_name: Finkelstein - first_name: A. full_name: Fontana, A. last_name: Fontana - first_name: M. full_name: Giavalisco, M. last_name: Giavalisco - first_name: M. full_name: Hirschmann, M. last_name: Hirschmann - first_name: I. full_name: Jung, I. last_name: Jung - first_name: A. M. full_name: Koekemoer, A. M. last_name: Koekemoer - first_name: V. full_name: Kokorev, V. last_name: Kokorev - first_name: M. full_name: Llerena, M. last_name: Llerena - first_name: R. A. full_name: Lucas, R. A. last_name: Lucas - first_name: Sara full_name: Mascia, Sara id: edaf889c-c7cd-11ef-ab1b-bb28c431bd29 last_name: Mascia - first_name: E. full_name: Merlin, E. last_name: Merlin - first_name: P. G. full_name: Pérez-González, P. G. last_name: Pérez-González - first_name: T. M. full_name: Stanton, T. M. last_name: Stanton - first_name: R. full_name: Tripodi, R. last_name: Tripodi - first_name: X. full_name: Wang, X. last_name: Wang - first_name: B. J. full_name: Weiner, B. J. last_name: Weiner citation: ama: 'Napolitano L, Pentericci L, Dickinson M, et al. Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202556912' apa: 'Napolitano, L., Pentericci, L., Dickinson, M., Arrabal Haro, P., Taylor, A. J., Calabrò, A., … Weiner, B. J. (2026). Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202556912' chicago: 'Napolitano, L., L. Pentericci, M. Dickinson, P. Arrabal Haro, A. J. Taylor, A. Calabrò, A. Bhagwat, et al. “Lyα Visibility from z = 4.5 to 11 in the UDS Field: Evidence for a High Neutral Hydrogen Fraction and Small Ionized Bubbles at z ∼ 7.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202556912.' ieee: 'L. Napolitano et al., “Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026.' ista: 'Napolitano L, Pentericci L, Dickinson M, Arrabal Haro P, Taylor AJ, Calabrò A, Bhagwat A, Santini P, Arevalo-Gonzalez F, Begley R, Castellano M, Ciardi B, Donnan CT, Dottorini D, Dunlop JS, Finkelstein SL, Fontana A, Giavalisco M, Hirschmann M, Jung I, Koekemoer AM, Kokorev V, Llerena M, Lucas RA, Mascia S, Merlin E, Pérez-González PG, Stanton TM, Tripodi R, Wang X, Weiner BJ. 2026. Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7. Astronomy & Astrophysics. 708, A102.' mla: 'Napolitano, L., et al. “Lyα Visibility from z = 4.5 to 11 in the UDS Field: Evidence for a High Neutral Hydrogen Fraction and Small Ionized Bubbles at z ∼ 7.” Astronomy & Astrophysics, vol. 708, A102, EDP Sciences, 2026, doi:10.1051/0004-6361/202556912.' short: L. Napolitano, L. Pentericci, M. Dickinson, P. Arrabal Haro, A.J. Taylor, A. Calabrò, A. Bhagwat, P. Santini, F. Arevalo-Gonzalez, R. Begley, M. Castellano, B. Ciardi, C.T. Donnan, D. Dottorini, J.S. Dunlop, S.L. Finkelstein, A. Fontana, M. Giavalisco, M. Hirschmann, I. Jung, A.M. Koekemoer, V. Kokorev, M. Llerena, R.A. Lucas, S. Mascia, E. Merlin, P.G. Pérez-González, T.M. Stanton, R. Tripodi, X. Wang, B.J. Weiner, Astronomy & Astrophysics 708 (2026). das_tickbox: '0' date_created: 2026-10-04T22:01:55Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-10-20T08:15:36Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.1051/0004-6361/202556912 external_id: arxiv: - '2508.14171' file: - access_level: open_access checksum: adff12137f194affedd27fa07c82e062 content_type: application/pdf creator: dernst date_created: 2026-10-12T07:09:27Z date_updated: 2026-10-12T07:09:27Z file_id: '23099' file_name: 2026_AstronomyAstrophysics_Napolitano.pdf file_size: 3265893 relation: main_file success: 1 file_date_updated: 2026-10-12T07:09:27Z fulldoi: https://doi.org/10.1051/0004-6361/202556912 has_accepted_license: '1' intvolume: ' 708' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: 'Lyα visibility from z = 4.5 to 11 in the UDS field: Evidence for a high neutral hydrogen fraction and small ionized bubbles at z ∼ 7' tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 708 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '23048' abstract: - lang: eng text: The previously inaccessible star formation tracer Paschen-Alpha (Paα) can now be spatially resolved by JWST NIRCam slitless spectroscopy in distant galaxies up to cosmic noon. In the first study of its kind, we combine JWST NGDEEP NIRISS and FRESCO NIRCam slitless spectroscopy to provide the first direct comparison of spatially resolved dust-obscured (traced by Paα) versus unobscured (traced by Hα) star formation across the main sequence. We stacked Paα and Hα emission-line maps, along with stellar continuum images at both wavelengths of 31 galaxies at 1 < z < 1.8 in three bins of stellar mass spanning 7.7 ≤ log(M*/M⊙) < 11. Surface brightness profiles were measured and equivalent width (EW) profiles computed. Increasing Paα and Hα EW profiles with galactocentric radius across all stellar masses probed provides direct evidence for the inside-out growth of galaxies both via dust-obscured and unobscured star formation for the first time. For galaxies predominantly on the main sequence (log(M*/M⊙)≥8.8), a weakly positive (0.1 ± 0.1) Paα/Hα line profile gradient as a function of radius is found at 8.8 ≤ log(M*/M⊙) < 9.9, with a negative (−0.4 ± 0.1) Paα/Hα line profile gradient as a function of radius found at the highest stellar masses of 9.9 ≤ log(M*/M⊙) < 11.0. Low-mass galaxies (7.7 ≤ log(M*/M⊙) < 8.8) with predominantly high specific star formation rates relative to the main sequence are also found to have a negative (−0.5 ± 0.1) Paα/Hα line profile gradient as a function of radius. Our results demonstrate that while inside-out growth via star formation is ubiquitous across the main sequence just after cosmic noon, centrally concentrated dust attenuation is not. Along with other recent work in the literature, our findings now motivate future studies of resolved SFR and dust attenuation profiles in large samples of individual cosmic noon galaxies across the main sequence, aimed at understanding the intrinsic scatter in spatially resolved star formation. acknowledgement: 'JM is grateful to the Max Planck Society for the MPIA Prize Fellowship and to the Cosmic Dawn Center for the DAWN Fellowship. This work is based on observations made with the NASA/ESA/CSA James Webb Space Telescope. The raw data were obtained from the Mikulski Archive for Space Telescopes at the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy, Inc., under NASA contract NAS 5-03127 for JWST. These observations are associated with JWST Cycle 1 GO programs #1895 and #2079. Support for both programs was provided by NASA through a grant from the Space Telescope Science Institute, which is operated by the Associations of Universities for Research in Astronomy, Incorporated, under NASA contract NAS5-26555. The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation under grant DNRF140. This work has received funding from the Swiss State Secretariat for Education, Research and Innovation (SERI) under contract number MB22.00072, as well as from the Swiss National Science Foundation (SNSF) through project grant 200020_207349. This work benefited from support from the George P. and Cynthia Woods Mitchell Institute for Fundamental Physics and Astronomy at Texas A&M University. CP thanks Marsha and Ralph Schilling for generous support of this research.' article_number: A33 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Jasleen full_name: Matharu, Jasleen last_name: Matharu - first_name: Lu full_name: Shen, Lu last_name: Shen - first_name: Irene full_name: Shivaei, Irene last_name: Shivaei - first_name: Pascal A. full_name: Oesch, Pascal A. last_name: Oesch - first_name: Casey full_name: Papovich, Casey last_name: Papovich - first_name: Gabriel full_name: Brammer, Gabriel last_name: Brammer - first_name: Naveen A. full_name: Reddy, Naveen A. last_name: Reddy - first_name: Yingjie full_name: Cheng, Yingjie last_name: Cheng - first_name: Pieter full_name: Van Dokkum, Pieter last_name: Van Dokkum - first_name: Steven L. full_name: Finkelstein, Steven L. last_name: Finkelstein - first_name: Nimish P. full_name: Hathi, Nimish P. last_name: Hathi - first_name: Jeyhan S. full_name: Kartaltepe, Jeyhan S. last_name: Kartaltepe - first_name: Anton M. full_name: Koekemoer, Anton M. last_name: Koekemoer - first_name: Jorryt J full_name: Matthee, Jorryt J id: 7439a258-f3c0-11ec-9501-9df22fe06720 last_name: Matthee orcid: 0000-0003-2871-127X - first_name: Nor full_name: Pirzkal, Nor last_name: Pirzkal - first_name: Stephen M. full_name: Wilkins, Stephen M. last_name: Wilkins - first_name: Michael A. full_name: Wozniak, Michael A. last_name: Wozniak - first_name: Mengyuan full_name: Xiao, Mengyuan last_name: Xiao citation: ama: Matharu J, Shen L, Shivaei I, et al. A first look at a complete view of spatially resolved star formation at 1  <  z  <  1.8 with JWST NGDEEP+FRESCO slitless spectroscopy. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202558205 apa: Matharu, J., Shen, L., Shivaei, I., Oesch, P. A., Papovich, C., Brammer, G., … Xiao, M. (2026). A first look at a complete view of spatially resolved star formation at 1  <  z  <  1.8 with JWST NGDEEP+FRESCO slitless spectroscopy. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202558205 chicago: Matharu, Jasleen, Lu Shen, Irene Shivaei, Pascal A. Oesch, Casey Papovich, Gabriel Brammer, Naveen A. Reddy, et al. “A First Look at a Complete View of Spatially Resolved Star Formation at 1  <  z  <  1.8 with JWST NGDEEP+FRESCO Slitless Spectroscopy.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202558205. ieee: J. Matharu et al., “A first look at a complete view of spatially resolved star formation at 1  <  z  <  1.8 with JWST NGDEEP+FRESCO slitless spectroscopy,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026. ista: Matharu J, Shen L, Shivaei I, Oesch PA, Papovich C, Brammer G, Reddy NA, Cheng Y, Van Dokkum P, Finkelstein SL, Hathi NP, Kartaltepe JS, Koekemoer AM, Matthee JJ, Pirzkal N, Wilkins SM, Wozniak MA, Xiao M. 2026. A first look at a complete view of spatially resolved star formation at 1  <  z  <  1.8 with JWST NGDEEP+FRESCO slitless spectroscopy. Astronomy & Astrophysics. 708, A33. mla: Matharu, Jasleen, et al. “A First Look at a Complete View of Spatially Resolved Star Formation at 1  <  z  <  1.8 with JWST NGDEEP+FRESCO Slitless Spectroscopy.” Astronomy & Astrophysics, vol. 708, A33, EDP Sciences, 2026, doi:10.1051/0004-6361/202558205. short: J. Matharu, L. Shen, I. Shivaei, P.A. Oesch, C. Papovich, G. Brammer, N.A. Reddy, Y. Cheng, P. Van Dokkum, S.L. Finkelstein, N.P. Hathi, J.S. Kartaltepe, A.M. Koekemoer, J.J. Matthee, N. Pirzkal, S.M. Wilkins, M.A. Wozniak, M. Xiao, Astronomy & Astrophysics 708 (2026). das_tickbox: '0' date_created: 2026-10-04T22:01:55Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-10-20T08:16:24Z day: '01' ddc: - '520' department: - _id: JoMa doi: 10.1051/0004-6361/202558205 external_id: arxiv: - '2511.15792' file: - access_level: open_access checksum: 875d217ea15192fa1208f3db34a7fad6 content_type: application/pdf creator: dernst date_created: 2026-10-12T07:31:23Z date_updated: 2026-10-12T07:31:23Z file_id: '23101' file_name: 2026_AstronomyAstrophysics_Matharu.pdf file_size: 587642 relation: main_file success: 1 file_date_updated: 2026-10-12T07:31:23Z fulldoi: https://doi.org/10.1051/0004-6361/202558205 has_accepted_license: '1' intvolume: ' 708' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: yes scopus_import: '1' status: public supplementarymaterial: no title: A first look at a complete view of spatially resolved star formation at 1  <  z  <  1.8 with JWST NGDEEP+FRESCO slitless spectroscopy tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 708 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '23045' abstract: - lang: eng text: "Context. In the convective envelopes of relatively cool (surface temperature ≲6700 K) stars, oscillations are excited by turbulent convection. In these so-called solar-like oscillators, radial oscillation modes appear at nearly equally spaced frequencies. This spacing is referred to as the ‘large-frequency separation’. Deviations from equally spaced frequencies are a result of the internal structure of a star being different from a sphere of ideal gas at constant temperature. Hence, these deviations provide information on the internal structure of the star.\r\n\r\nAims. In this work, we investigate the second-order (quadratic) deviation from uniform spacing, referred to as curvature. We aim to provide homogeneous values for observed red-giant stars, understand differences between the results from observations and predictions from stellar models, and reveal the connection between curvature and stellar structure.\r\n\r\nMethods. We used Kepler data of red-giant stars and computed the curvature for several thousand stars. We compared these to the curvature derived from MESA models. We subsequently investigated the trends and differences between results from observations and models. Finally, we computed sensitivity kernels to identify the stellar region(s) to which the curvature is most sensitive and performed a glitch analysis.\r\n\r\nResults. We found that the curvature is sensitive to evolutionary phase and mass. Interestingly, the observed values and values from models show some discrepancies. Including the surface effect in the model frequencies reduces the discrepancies, though it introduces a frequency-dependent over- or under-estimation of the curvature from the models compared to the observations. From the kernels, we confirmed that the curvature is mostly sensitive to the near-surface layers of the star. The glitch analysis shows that in theory this provides information on the location and strength of the He I and H I ionisation layers.\r\n\r\nConclusions. The curvature provides a probe into the near-surface structure of the star. The deviations between the curvature derived from observations and models call for improvements in the near-surface layers of stellar models." acknowledgement: "We thank the referee and editor for their comments\r\nand work, which improved the manuscript significantly. We acknowledge funding from the ERC Consolidator Grant ‘DipolarSound’ (grant agreement #\r\n101000296). SB is partially supported by NSF grant AST-2205026. YE acknowledges funding from the Science and Technology Facilities Council (STFC)" article_number: A84 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: S. full_name: Hekker, S. last_name: Hekker - first_name: Y. full_name: Elsworth, Y. last_name: Elsworth - first_name: S. full_name: Basu, S. last_name: Basu - first_name: F. full_name: Ahlborn, F. last_name: Ahlborn - first_name: W. H. full_name: Ball, W. H. last_name: Ball - first_name: E. P. full_name: Bellinger, E. P. last_name: Bellinger - first_name: Lynn full_name: Buchele, Lynn id: 158c74c1-eed5-11ef-8c05-e45f52925cdc last_name: Buchele - first_name: F. full_name: Espinoza-Rojas, F. last_name: Espinoza-Rojas citation: ama: Hekker S, Elsworth Y, Basu S, et al. The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars. Astronomy & Astrophysics. 2026;709. doi:10.1051/0004-6361/202557690 apa: Hekker, S., Elsworth, Y., Basu, S., Ahlborn, F., Ball, W. H., Bellinger, E. P., … Espinoza-Rojas, F. (2026). The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202557690 chicago: Hekker, S., Y. Elsworth, S. Basu, F. Ahlborn, W. H. Ball, E. P. Bellinger, Lynn Buchele, and F. Espinoza-Rojas. “The Sensitivity and Behaviour of the Curvature in the Échelle Diagram of Red-Giant Stars.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202557690. ieee: S. Hekker et al., “The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars,” Astronomy & Astrophysics, vol. 709. EDP Sciences, 2026. ista: Hekker S, Elsworth Y, Basu S, Ahlborn F, Ball WH, Bellinger EP, Buchele L, Espinoza-Rojas F. 2026. The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars. Astronomy & Astrophysics. 709, A84. mla: Hekker, S., et al. “The Sensitivity and Behaviour of the Curvature in the Échelle Diagram of Red-Giant Stars.” Astronomy & Astrophysics, vol. 709, A84, EDP Sciences, 2026, doi:10.1051/0004-6361/202557690. short: S. Hekker, Y. Elsworth, S. Basu, F. Ahlborn, W.H. Ball, E.P. Bellinger, L. Buchele, F. Espinoza-Rojas, Astronomy & Astrophysics 709 (2026). das_tickbox: '0' date_created: 2026-10-04T22:01:54Z date_published: 2026-05-01T00:00:00Z date_updated: 2026-10-20T08:14:24Z day: '01' ddc: - '520' department: - _id: LiBu doi: 10.1051/0004-6361/202557690 external_id: arxiv: - '2603.16597' file: - access_level: open_access checksum: 6f5d496ee876c8ff4bce6924be2cad19 content_type: application/pdf creator: dernst date_created: 2026-10-07T12:35:39Z date_updated: 2026-10-07T12:35:39Z file_id: '23077' file_name: 2026_AstronomyAstrophysics_Hekker.pdf file_size: 13650005 relation: main_file success: 1 file_date_updated: 2026-10-07T12:35:39Z fulldoi: https://doi.org/10.1051/0004-6361/202557690 has_accepted_license: '1' intvolume: ' 709' language: - iso: eng month: '05' oa: 1 oa_version: Published Version publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: The sensitivity and behaviour of the curvature in the échelle diagram of red-giant stars tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 709 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: diamond PlanS_conform: '1' _id: '23047' abstract: - lang: eng text: "Aims. We investigate signatures of pressure extrema on global oscillations in discs.\r\n\r\nMethods. We used the framework of wave topology to establish a generalised local dispersion relation that includes pressure gradients. We highlight the influence of a previously unrecognised epicyclic–acoustic frequency, and we derive an analytical criterion for the existence of a branch of modes transiting between the inertial and the pressure bands, known as topological modes.\r\n\r\nResults. We find that pressure extrema consist of wave guides in which such topological modes propagate. The fundamental mode trapped at a pressure bump can propagate at any frequency, allowing it to resonate with any temporal forcing. Conversely, the fundamental mode associated with a pressure dip propagates at any vertical phase velocity. These specific features make them attractive candidates for future discoseismology." acknowledgement: "AL was funded by Contrat Doctoral Spécifique Normaliens during this work. GL, EL and NP acknowledge funding from\r\nERC CoG project PODCAST No 864965. AL acknowledges funding\r\nfrom ERC StG project Calcifer No 101165631. We used Mathematica\r\n(Wolfram Research Inc, 2024).\r\n" article_number: A355 article_processing_charge: No article_type: original arxiv: 1 author: - first_name: Armand full_name: Leclerc, Armand id: 2a1fb1fc-f373-11ef-901a-87cee43a1217 last_name: Leclerc - first_name: Guillaume full_name: Laibe, Guillaume last_name: Laibe - first_name: Elliot full_name: Lynch, Elliot last_name: Lynch - first_name: Nicolas full_name: Perez, Nicolas last_name: Perez citation: ama: Leclerc A, Laibe G, Lynch E, Perez N. Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. 2026;708. doi:10.1051/0004-6361/202558428 apa: Leclerc, A., Laibe, G., Lynch, E., & Perez, N. (2026). Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. EDP Sciences. https://doi.org/10.1051/0004-6361/202558428 chicago: Leclerc, Armand, Guillaume Laibe, Elliot Lynch, and Nicolas Perez. “Radial Modes of Pressure Bumps and Dips in Astrophysical Discs.” Astronomy & Astrophysics. EDP Sciences, 2026. https://doi.org/10.1051/0004-6361/202558428. ieee: A. Leclerc, G. Laibe, E. Lynch, and N. Perez, “Radial modes of pressure bumps and dips in astrophysical discs,” Astronomy & Astrophysics, vol. 708. EDP Sciences, 2026. ista: Leclerc A, Laibe G, Lynch E, Perez N. 2026. Radial modes of pressure bumps and dips in astrophysical discs. Astronomy & Astrophysics. 708, A355. mla: Leclerc, Armand, et al. “Radial Modes of Pressure Bumps and Dips in Astrophysical Discs.” Astronomy & Astrophysics, vol. 708, A355, EDP Sciences, 2026, doi:10.1051/0004-6361/202558428. short: A. Leclerc, G. Laibe, E. Lynch, N. Perez, Astronomy & Astrophysics 708 (2026). corr_author: '1' das_tickbox: '1' dataavailabilitystatement: "The scripts written and used for numerical calculations\r\nare accessible at https://github.com/ArmandLeclerc/\r\nradialStratifDisc." date_created: 2026-10-04T22:01:54Z date_published: 2026-04-01T00:00:00Z date_updated: 2026-10-20T08:14:41Z day: '01' ddc: - '520' department: - _id: LiBu doi: 10.1051/0004-6361/202558428 external_id: arxiv: - '2512.05737' file: - access_level: open_access checksum: 868c1be53a4f3e0cf2852a723fcacd08 content_type: application/pdf creator: dernst date_created: 2026-10-07T12:13:55Z date_updated: 2026-10-07T12:13:55Z file_id: '23075' file_name: 2026_AstronomyAstrophysics_Leclerc.pdf file_size: 10533299 relation: main_file success: 1 file_date_updated: 2026-10-07T12:13:55Z fulldoi: https://doi.org/10.1051/0004-6361/202558428 has_accepted_license: '1' intvolume: ' 708' keyword: - accretion - accretion disks - hydrodynamics - instabilities - waves - protoplanetary disks language: - iso: eng month: '04' oa: 1 oa_version: Published Version project: - _id: 914d8549-16d5-11f0-9cad-bbe6324c93a9 grant_number: '101165631' name: 'Unveiling the mysteries of stellar dynamics: a pioneering journey in magnetoasteroseismology' publication: Astronomy & Astrophysics publication_identifier: eissn: - 1432-0746 issn: - 0004-6361 publication_status: published publisher: EDP Sciences quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: yes title: Radial modes of pressure bumps and dips in astrophysical discs tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 708 year: '2026' ... --- OA_embargo: '12' OA_place: publisher _id: '22744' acknowledged_ssus: - _id: Bio - _id: EM-Fac - _id: ScienComp - _id: LifeSc acknowledgement: "This work was supported by the ERC StG grant ActinID (PRA01221F1049A) awarded to Florian\r\nSchur, the ERC-SyG grant Pushing from within (P01071793) awarded to Michael Sixt, and by ISTA.\r\nI would like to thank the Scientific Service Units at ISTA for their essential support throughout\r\nthis work. In particular, I am grateful to the Electron Microscopy Facility, Imaging and Optics\r\nFacility, Zebrafish Facility, Scientific Computing Facility, and Lab Support Facility for their services,\r\nand technical support, all of which were important for the successful completion of this project." alternative_title: - ISTA Thesis article_processing_charge: No author: - first_name: Manjunath full_name: Javoor, Manjunath id: 305ab18b-dc7d-11ea-9b2f-b58195228ea2 last_name: Javoor orcid: 0000-0003-2311-2112 citation: ama: Javoor M. Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. 2026. doi:10.15479/AT-ISTA-22744 apa: Javoor, M. (2026). Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. Institute of Science and Technology Austria . https://doi.org/10.15479/AT-ISTA-22744 chicago: Javoor, Manjunath. “Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography.” Institute of Science and Technology Austria , 2026. https://doi.org/10.15479/AT-ISTA-22744. ieee: M. Javoor, “Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography,” Institute of Science and Technology Austria , 2026. ista: Javoor M. 2026. Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography. Institute of Science and Technology Austria . mla: Javoor, Manjunath. Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography. Institute of Science and Technology Austria , 2026, doi:10.15479/AT-ISTA-22744. short: M. Javoor, Large-Scale Imaging of Cellular Actin Networks at Single Filament Resolution Using Montage Cryo-Electron Tomography, Institute of Science and Technology Austria , 2026. corr_author: '1' date_created: 2026-08-21T09:11:04Z date_published: 2026-08-21T00:00:00Z date_updated: 2026-10-20T08:55:33Z day: '21' ddc: - '570' degree_awarded: PhD department: - _id: GradSch - _id: FlSc - _id: MiSi doi: 10.15479/AT-ISTA-22744 doi_confirm: '1' file: - access_level: closed checksum: f9c2847df9f1ac5a3d60c06b3b81a450 content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document creator: mjavoor date_created: 2026-08-26T12:02:47Z date_updated: 2026-08-27T12:48:42Z file_id: '22767' file_name: 2026_Javoor_Manjunath_Thesis.docx file_size: 27430796 relation: source_file - access_level: closed checksum: 8e9b4c0fcafbccf5c3796eacc9134a08 content_type: application/pdf creator: mjavoor date_created: 2026-08-26T12:02:46Z date_updated: 2026-08-26T12:02:46Z embargo: 2027-08-21 embargo_to: open_access file_id: '22768' file_name: 2026_Javoor_Manjunath_Thesis.pdf file_size: 19489230 relation: main_file file_date_updated: 2026-08-27T12:48:42Z fulldoi: https://doi.org/10.15479/AT-ISTA-22744 has_accepted_license: '1' keyword: - Actin cytoskeleton - Cell migration - cryo-electron tomography language: - iso: eng month: '08' oa_version: None page: '121' project: - _id: bd980d18-d553-11ed-ba76-ceaa645c97eb grant_number: '101076260' name: A molecular atlas of Actin filament IDentities in the cell motility machinery - _id: bd91e723-d553-11ed-ba76-fe7eeb2185fd grant_number: '101071793' name: 'Pushing from within: Control of cell shape, integrity and motility by cytoskeletal pushing forces' publication_identifier: isbn: - '978-3-99078-090-9 ' issn: - 2663-337X publication_status: published publisher: 'Institute of Science and Technology Austria ' related_material: record: - id: '12334' relation: part_of_dissertation status: public - id: '21762' relation: part_of_dissertation status: public - id: '12421' relation: part_of_dissertation status: public - id: '19795' relation: part_of_dissertation status: public status: public supervisor: - first_name: Florian KM full_name: Schur, Florian KM id: 48AD8942-F248-11E8-B48F-1D18A9856A87 last_name: Schur orcid: 0000-0003-4790-8078 - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 title: Large-scale imaging of cellular actin networks at single filament resolution using montage cryo-electron tomography tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: dissertation user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21754' abstract: - lang: eng text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Research on OoL spans many disciplines, including chemistry, physics, biology, planetary sciences, computer science, and mathematics. The sheer number of different scientific perspectives relevant to the problem has resulted in the coexistence of diverse tools, techniques, data, and software in OoL studies. This has made communication between the disciplines relevant to the OoL extremely difficult because the interpretation of data, analyses, or standards of evidence varies dramatically. Here, we hope to bridge this wide field of study by providing common ground via the consolidation of techniques rather than positing a unifying view on how life emerges. In part 1 of this review, we cover common experimental techniques that have been used significantly in OoL studies in recent years, while in part 2, we review theoretical, computational, and integrative methods. Here, we discuss the use of spectroscopy, spectrometry, chromatography, microscopy, and sequencing methods for characterizing diverse materials. We further discuss the role of data repositories in facilitating the analysis and dissemination of experimental data. This review provides a baseline expectation and understanding of the analytical aspects of origins’ research. Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary collaborations in OoL research by helping scientists understand what they can do about the problem of life’s origins, rather than telling them how to think about it. acknowledgement: This work is a collaborative effort of the titled authors as part of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the first author to give a better representation of this team effort, rather than listing any single author as the first author. We hope such a thing can be adopted by others. We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M., Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed alphabetically by their last names. We would like to acknowledge all current and past members of OoLEN for their contributions to our community. In particular, we would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript; this work was significantly improved through their feedback. S.A. acknowledges support from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051) and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987). C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges support from Centre national d'études spatiales (CNES) and postdoctoral support from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges support from UT System for a STARs award. A.C.-R. acknowledges funding from the Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018), the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology Program administered by Oak Ridge Associated Universities under contract with NASA. S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015). T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS) grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences, and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges support from NASA through the postdoctoral Fellowship Program. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of NASA. O.M. acknowledges support from The John Templeton Foundation (#62828) and the Foundation for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence Cluster) and is a fellow of the International Max Planck Research School for Astronomy and Cosmic Physics at the University of Heidelberg (IMPRS-HD). article_number: '103212' article_processing_charge: Yes article_type: original author: - first_name: Silke full_name: Asche, Silke last_name: Asche - first_name: Carla full_name: Bautista, Carla last_name: Bautista - first_name: Celia full_name: Blanco, Celia last_name: Blanco - first_name: David full_name: Boulesteix, David last_name: Boulesteix - first_name: Alexandre full_name: Champagne-Ruel, Alexandre last_name: Champagne-Ruel - first_name: Cole full_name: Mathis, Cole last_name: Mathis - first_name: Omer full_name: Markovitch, Omer last_name: Markovitch - first_name: Zhen full_name: Peng, Zhen last_name: Peng - first_name: Avinash Vicholous full_name: Dass, Avinash Vicholous last_name: Dass - first_name: Alyssa full_name: Adams, Alyssa last_name: Adams - first_name: Eloi full_name: Camprubi, Eloi last_name: Camprubi - first_name: Enrico Sandro full_name: Colizzi, Enrico Sandro last_name: Colizzi - first_name: Stephanie full_name: Colón-Santos, Stephanie last_name: Colón-Santos - first_name: Hannah full_name: Dromiack, Hannah last_name: Dromiack - first_name: Valentina full_name: Erastova, Valentina last_name: Erastova - first_name: Amanda full_name: Garcia, Amanda last_name: Garcia - first_name: Ghjuvan full_name: Grimaud, Ghjuvan last_name: Grimaud - first_name: Aaron full_name: Halpern, Aaron last_name: Halpern - first_name: Stuart A. full_name: Harrison, Stuart A. last_name: Harrison - first_name: Seán F. full_name: Jordan, Seán F. last_name: Jordan - first_name: Tony Z. full_name: Jia, Tony Z. last_name: Jia - first_name: Amit full_name: Kahana, Amit last_name: Kahana - first_name: Artemy full_name: Kolchinsky, Artemy last_name: Kolchinsky - first_name: Odin full_name: Moron-Garcia, Odin last_name: Moron-Garcia - first_name: Ryo full_name: Mizuuchi, Ryo last_name: Mizuuchi - first_name: Jingbo full_name: Nan, Jingbo last_name: 'Nan' - first_name: Yuliia full_name: Orlova, Yuliia last_name: Orlova - first_name: Ben K.D. full_name: Pearce, Ben K.D. last_name: Pearce - first_name: Klaus full_name: Paschek, Klaus last_name: Paschek - first_name: Martina full_name: Preiner, Martina last_name: Preiner - first_name: Silvana full_name: Pinna, Silvana last_name: Pinna - first_name: Eduardo full_name: Rodríguez-Román, Eduardo last_name: Rodríguez-Román - first_name: Loraine full_name: Schwander, Loraine last_name: Schwander - first_name: Siddhant full_name: Sharma, Siddhant id: 36996868-4916-11f1-8c9d-c0c901467b61 last_name: Sharma - first_name: Harrison B. full_name: Smith, Harrison B. last_name: Smith - first_name: Andrey full_name: Vieira, Andrey last_name: Vieira - first_name: Joana C. full_name: Xavier, Joana C. last_name: Xavier citation: ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103212' apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis, C., … Xavier, J. C. (2026). What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. Cell Press. https://doi.org/10.1016/j.xcrp.2026.103212' chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the Origin of Life: An Integrated Review. Part 1–Experimental Methods and Data Repositories.” Cell Reports Physical Science. Cell Press, 2026. https://doi.org/10.1016/j.xcrp.2026.103212.' ieee: 'S. Asche et al., “What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories,” Cell Reports Physical Science, vol. 7, no. 4. Cell Press, 2026.' ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C, Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S, Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF, Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S, Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories. Cell Reports Physical Science. 7(4), 103212.' mla: 'Asche, Silke, et al. “What It Takes to Solve the Origin of Life: An Integrated Review. Part 1–Experimental Methods and Data Repositories.” Cell Reports Physical Science, vol. 7, no. 4, 103212, Cell Press, 2026, doi:10.1016/j.xcrp.2026.103212.' short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis, O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos, H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F. Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan, Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román, L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical Science 7 (2026). date_created: 2026-04-19T22:07:52Z date_published: 2026-04-15T00:00:00Z date_updated: 2026-10-20T08:59:19Z day: '15' ddc: - '570' doi: 10.1016/j.xcrp.2026.103212 file: - access_level: open_access checksum: e580d22c2874c0afcbde2d167db7201b content_type: application/pdf creator: dernst date_created: 2026-05-07T05:48:23Z date_updated: 2026-05-07T05:48:23Z file_id: '21831' file_name: 2026_CellREports_OoLEN1.pdf file_size: 3535247 relation: main_file success: 1 file_date_updated: 2026-05-07T05:48:23Z fulldoi: https://doi.org/10.1016/j.xcrp.2026.103212 has_accepted_license: '1' intvolume: ' 7' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Cell Reports Physical Science publication_identifier: eissn: - 2666-3864 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: 'What it takes to solve the origin of life: An integrated review. Part 1–Experimental methods and data repositories' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21753' abstract: - lang: eng text: The origin(s) of life (OoL), which has puzzled scientists for centuries, remains a major scientific challenge in the 21st century. Understanding the processes relevant to the OoL demands theoretical frameworks that can connect processes across scales, from microscopic dynamics to emergent levels of organization. While experimental studies generate a wealth of data, theoretical and computational approaches provide the structure necessary to interpret and generalize these findings. In Part 1, we examined the most widely used experimental techniques in the field. Here, we focus on the mathematical, physical, and computational techniques used to model phenomena relevant to life’s origin(s). We discuss methods ranging from quantum chemistry and molecular dynamics to chemical reaction networks, autocatalysis, and evolutionary modeling, as well as information-theoretic and phylogenetic approaches that link chemical and biological organization. We further highlight emerging trends such as synthetic biology, omics-based methods, and laboratory automation as novel points of contact for theory-experiment integration. Ultimately, we aim to provide an educational tool that can facilitate more post-disciplinary collaborations in OoL research by helping scientists understand what they can do about the problem of life’s origins, rather than telling them how to think about it. acknowledgement: This work is a collaborative effort of the titled authors as part of the Origin of Life Early Career Network (OoLEN). We chose to add OoLEN as the first author to give a better representation of this team effort, rather than listing any single author as the first author. We hope such a thing can be adopted by others. We indicate that authors 2–9 (S.A., C.B., C. Blanco, D.B., A.C.-R., C.M., O.M., Z.P., and A.V.D.) have made a more distinct contribution. All authors are listed alphabetically by their last names. We would like to acknowledge all current and past members of OoLEN for their contributions to our community. In particular, we would like to acknowledge Evrim Fer, who helped with molecular phylogenetics. We would like to thank the anonymous referees for reviewing Parts 1 and 2 of this manuscript; this work was significantly improved through their feedback. S.A. acknowledges support from NASA through the postdoctoral Program at GSFC. C. Bautista acknowledges support from “la Caixa” Foundation (ID 100010434) under agreement (LCF/BQ/AA16/11580051) and by the Fonds de recherche du Québec Nature et technologies (FRQNT) (#274987). C. Blanco acknowledges support from NASA under award 80NSSC21K0595. D.B. acknowledges support from Centre national d'études spatiales (CNES) and postdoctoral support from LGPM-CentralSupélec and NASA under award 80NSSC23K1477. E. Camprubi acknowledges support from UT System for a STARs award. A.C.-R. acknowledges funding from the Natural Sciences and Engineering Research Council of Canada (grant number RGPIN/05278–2018), the Fonds de recherche Nature et Technologies of Québec (grant number 314488), and the Fondation J. Armand Bombardier Excellence Scholarship. A.C.-R.’s research was supported by an appointment to the NASA Postdoctoral Program from the NASA Astrobiology Program administered by Oak Ridge Associated Universities under contract with NASA. S.F.J. acknowledges support from “la Caixa” Foundation (ID 100010434) and from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska Curie grant agreement no. 847648 (the fellowship code is LCF/BQ/PI21/11830015). T.Z.J. acknowledges support from Japan Society for the Promotion of Science (JSPS) grants-in-aid 18K14354 and 21K14746, a Tokyo Institute of Technology Yoshinori Ohsumi Fund for Fundamental Research, the Mizuho Foundation for the Promotion of Sciences, and by the Temporary Assistant Program by the DE&I Section of Science Tokyo. A.K. acknowledges support from the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie Grant agreement no. 101068029. C.M. acknowledges support from NASA through the postdoctoral Fellowship Program. The views and conclusions contained in this document are those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of NASA. O.M. acknowledges support from The John Templeton Foundation (#62828) and the Foundation for Science and Technology (2023.05971.CEECIND). B.K.D.P. acknowledges support from the NSERC Banting Postdoctoral Fellowship. K.P. acknowledges financial support from the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany’s Excellence Strategy EXC 2181/1 - 390900948 (the Heidelberg STRUCTURES Excellence Cluster) and is a fellow of the International Max Planck Research School for Astronomy and Cosmic Physics at the University of Heidelberg (IMPRS-HD). article_number: '103211' article_processing_charge: Yes article_type: original author: - first_name: Silke full_name: Asche, Silke last_name: Asche - first_name: Carla full_name: Bautista, Carla last_name: Bautista - first_name: Celia full_name: Blanco, Celia last_name: Blanco - first_name: David full_name: Boulesteix, David last_name: Boulesteix - first_name: Alexandre full_name: Champagne-Ruel, Alexandre last_name: Champagne-Ruel - first_name: Cole full_name: Mathis, Cole last_name: Mathis - first_name: Omer full_name: Markovitch, Omer last_name: Markovitch - first_name: Zhen full_name: Peng, Zhen last_name: Peng - first_name: Avinash Vicholous full_name: Dass, Avinash Vicholous last_name: Dass - first_name: Alyssa full_name: Adams, Alyssa last_name: Adams - first_name: Eloi full_name: Camprubi, Eloi last_name: Camprubi - first_name: Enrico Sandro full_name: Colizzi, Enrico Sandro last_name: Colizzi - first_name: Stephanie full_name: Colón-Santos, Stephanie last_name: Colón-Santos - first_name: Hannah full_name: Dromiack, Hannah last_name: Dromiack - first_name: Valentina full_name: Erastova, Valentina last_name: Erastova - first_name: Amanda full_name: Garcia, Amanda last_name: Garcia - first_name: Ghjuvan full_name: Grimaud, Ghjuvan last_name: Grimaud - first_name: Aaron full_name: Halpern, Aaron last_name: Halpern - first_name: Stuart A. full_name: Harrison, Stuart A. last_name: Harrison - first_name: Seán F. full_name: Jordan, Seán F. last_name: Jordan - first_name: Tony Z. full_name: Jia, Tony Z. last_name: Jia - first_name: Amit full_name: Kahana, Amit last_name: Kahana - first_name: Artemy full_name: Kolchinsky, Artemy last_name: Kolchinsky - first_name: Odin full_name: Moron-Garcia, Odin last_name: Moron-Garcia - first_name: Ryo full_name: Mizuuchi, Ryo last_name: Mizuuchi - first_name: Jingbo full_name: Nan, Jingbo last_name: 'Nan' - first_name: Yuliia full_name: Orlova, Yuliia last_name: Orlova - first_name: Ben K.D. full_name: Pearce, Ben K.D. last_name: Pearce - first_name: Klaus full_name: Paschek, Klaus last_name: Paschek - first_name: Martina full_name: Preiner, Martina last_name: Preiner - first_name: Silvana full_name: Pinna, Silvana last_name: Pinna - first_name: Eduardo full_name: Rodríguez-Román, Eduardo last_name: Rodríguez-Román - first_name: Loraine full_name: Schwander, Loraine last_name: Schwander - first_name: Siddhant full_name: Sharma, Siddhant id: 36996868-4916-11f1-8c9d-c0c901467b61 last_name: Sharma - first_name: Harrison B. full_name: Smith, Harrison B. last_name: Smith - first_name: Andrey full_name: Vieira, Andrey last_name: Vieira - first_name: Joana C. full_name: Xavier, Joana C. last_name: Xavier citation: ama: 'Asche S, Bautista C, Blanco C, et al. What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. 2026;7(4). doi:10.1016/j.xcrp.2026.103211' apa: 'Asche, S., Bautista, C., Blanco, C., Boulesteix, D., Champagne-Ruel, A., Mathis, C., … Xavier, J. C. (2026). What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. Cell Press. https://doi.org/10.1016/j.xcrp.2026.103211' chicago: 'Asche, Silke, Carla Bautista, Celia Blanco, David Boulesteix, Alexandre Champagne-Ruel, Cole Mathis, Omer Markovitch, et al. “What It Takes to Solve the Origins of Life: An Integrated Review. Part 2: Theoretical Methods and Emerging Trends.” Cell Reports Physical Science. Cell Press, 2026. https://doi.org/10.1016/j.xcrp.2026.103211.' ieee: 'S. Asche et al., “What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends,” Cell Reports Physical Science, vol. 7, no. 4. Cell Press, 2026.' ista: 'Asche S, Bautista C, Blanco C, Boulesteix D, Champagne-Ruel A, Mathis C, Markovitch O, Peng Z, Dass AV, Adams A, Camprubi E, Colizzi ES, Colón-Santos S, Dromiack H, Erastova V, Garcia A, Grimaud G, Halpern A, Harrison SA, Jordan SF, Jia TZ, Kahana A, Kolchinsky A, Moron-Garcia O, Mizuuchi R, Nan J, Orlova Y, Pearce BKD, Paschek K, Preiner M, Pinna S, Rodríguez-Román E, Schwander L, Sharma S, Smith HB, Vieira A, Xavier JC. 2026. What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends. Cell Reports Physical Science. 7(4), 103211.' mla: 'Asche, Silke, et al. “What It Takes to Solve the Origins of Life: An Integrated Review. Part 2: Theoretical Methods and Emerging Trends.” Cell Reports Physical Science, vol. 7, no. 4, 103211, Cell Press, 2026, doi:10.1016/j.xcrp.2026.103211.' short: S. Asche, C. Bautista, C. Blanco, D. Boulesteix, A. Champagne-Ruel, C. Mathis, O. Markovitch, Z. Peng, A.V. Dass, A. Adams, E. Camprubi, E.S. Colizzi, S. Colón-Santos, H. Dromiack, V. Erastova, A. Garcia, G. Grimaud, A. Halpern, S.A. Harrison, S.F. Jordan, T.Z. Jia, A. Kahana, A. Kolchinsky, O. Moron-Garcia, R. Mizuuchi, J. Nan, Y. Orlova, B.K.D. Pearce, K. Paschek, M. Preiner, S. Pinna, E. Rodríguez-Román, L. Schwander, S. Sharma, H.B. Smith, A. Vieira, J.C. Xavier, Cell Reports Physical Science 7 (2026). date_created: 2026-04-19T22:07:50Z date_published: 2026-04-15T00:00:00Z date_updated: 2026-10-20T08:58:31Z day: '15' ddc: - '570' doi: 10.1016/j.xcrp.2026.103211 file: - access_level: open_access checksum: d5abe5b5bd4b9ee58aa6f4917f688ad9 content_type: application/pdf creator: dernst date_created: 2026-05-06T06:48:33Z date_updated: 2026-05-06T06:48:33Z file_id: '21804' file_name: 2026_CellReports_OoLEN.pdf file_size: 5265320 relation: main_file success: 1 file_date_updated: 2026-05-06T06:48:33Z fulldoi: https://doi.org/10.1016/j.xcrp.2026.103211 has_accepted_license: '1' intvolume: ' 7' issue: '4' language: - iso: eng month: '04' oa: 1 oa_version: Published Version publication: Cell Reports Physical Science publication_identifier: eissn: - 2666-3864 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: 'What it takes to solve the origins of life: An integrated review. Part 2: Theoretical methods and emerging trends' tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 7 year: '2026' ... --- DOAJ_listed: '1' OA_place: publisher OA_type: gold _id: '21744' abstract: - lang: eng text: The paraventricular hypothalamus (PVH) controls behavioral and physiologic processes, including appetite, social behavior, autonomic outflow, and pituitary hormone secretion. However, molecular markers for centrally projecting PVH neuron populations remain largely undefined, and a complete census of PVH cell types has not been established. Therefore, we performed extensive single-cell/nucleus RNA sequencing to catalog PVH neuron subtypes and multiplexed error-robust fluorescence in situ hybridization (MERFISH) to map them spatially. Our spatial transcriptomic atlas resolves 26 Sim1+ and 29 GABAergic neuron populations from the PVH and surrounding areas. Additionally, projection-based profiling identified neurons that project to the parabrachial region (PB) and spinal cord, helping to determine PVH populations that regulate satiety and sympathetic nervous system activity, respectively. Notably, activation of PB-projecting PVH neurons expressing Brs3 reduces food intake, and silencing them causes obesity. Together, this atlas contributes high-resolution PVH spatial and circuit-based gene expression profiles, representing a valuable resource for the field of homeostasis. acknowledgement: "We would like to thank Drs. Mark Andermann, Joel Geerling, and Clifford\r\nSaper, as well as the Lowell, Tsai, and Resch laboratories for helpful discussions;\r\nAlysia Berns, Jia Yu, and Yanfang Li for technical support; the BNORC\r\nFunctional Genomics and Bioinformatics Core (P30DK046200) and the Iowa\r\nInstitute for Human Genetics Genomics Division (IIHG, RRID: SCR_023422)\r\nfor helpful discussions and technical assistance with sc/snRNA-seq; Zachary\r\nNiziolek and the Bauer Core Facility at Harvard University, the BIDMC Flow Cytometry\r\nCore, and Heath Vignes, Michael Shey, and Thomas Kaufman of the\r\nFlow Cytometry Facility at the University of Iowa Carver College of Medicine\r\nfor helpful discussions and technical support; the ICCB-Longwood Screening\r\nFacility of Harvard Medical School for assistance with the snRNA-seq\r\nexperiments; Dr. Sayak Mitter and Vizgen support for technical assistance\r\nwith the MERSCOPE platform; and Mara Jendro and Li-Chun (Queena) Lin\r\nfor their assistance with MERSCOPE experiments within the Iowa\r\nNeuroBank Core in the Iowa Neuroscience Institute at the University of Iowa\r\nCarver College of Medicine. This research was funded by the following NIH\r\ngrants to L.T.T.: R01DK128406; to B.B.L.: R01DK075632, R01DK134427,\r\nand R01DK096010; to J.M.R.: R00HL144923 and R01NS141072; and to M.C.M.: F31HL170784; T.C.B. and M.C.M. were supported by a pharmacological\r\nsciences predoctoral training grant T32GM144636. Additional funding\r\nto J.M.R. came from the American Heart Association (AHA 935362), a University\r\nof Iowa Fraternal Order of Eagles Diabetes Research Center Pilot and\r\nFeasibility Catalyst Grant, and an Iowa Neuroscience Institute Early Stage\r\nInvestigator award from the Carver Trust. Y.L. was supported by a predoctoral\r\nfellowship from the American Heart Association (AHA 25PRE1372983). A.M.D.\r\nwas supported by a postdoctoral fellowship from the Charles A. King Trust." article_number: '116904' article_processing_charge: Yes article_type: original author: - first_name: Yuxi full_name: Li, Yuxi last_name: Li - first_name: Trevor C. full_name: Butler, Trevor C. last_name: Butler - first_name: Stefano full_name: Nardone, Stefano last_name: Nardone - first_name: Christopher L. full_name: Jacobs, Christopher L. last_name: Jacobs - first_name: Amelia May Barnett full_name: Douglass, Amelia May Barnett id: de5f6fda-80fb-11ef-996f-a8c4ecd8e289 last_name: Douglass orcid: 0000-0001-5398-6473 - first_name: Joseph C. full_name: Madara, Joseph C. last_name: Madara - first_name: Miriam C. full_name: McDonough, Miriam C. last_name: McDonough - first_name: Jenkang full_name: Tao, Jenkang last_name: Tao - first_name: Elijah D. full_name: Lowenstein, Elijah D. last_name: Lowenstein - first_name: Luhong full_name: Wang, Luhong last_name: Wang - first_name: Deepti full_name: Pant, Deepti last_name: Pant - first_name: Samuel J. full_name: Walker, Samuel J. last_name: Walker - first_name: Annette full_name: Wang, Annette last_name: Wang - first_name: Harini full_name: Srinivasan, Harini last_name: Srinivasan - first_name: Zongfang full_name: Yang, Zongfang last_name: Yang - first_name: John N. full_name: Campbell, John N. last_name: Campbell - first_name: Linus T. full_name: Tsai, Linus T. last_name: Tsai - first_name: Bradford B. full_name: Lowell, Bradford B. last_name: Lowell - first_name: Jon M. full_name: Resch, Jon M. last_name: Resch citation: ama: Li Y, Butler TC, Nardone S, et al. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. 2026;45(2). doi:10.1016/j.celrep.2025.116904 apa: Li, Y., Butler, T. C., Nardone, S., Jacobs, C. L., Douglass, A. M., Madara, J. C., … Resch, J. M. (2026). A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. Cell Press. https://doi.org/10.1016/j.celrep.2025.116904 chicago: Li, Yuxi, Trevor C. Butler, Stefano Nardone, Christopher L. Jacobs, Amelia M. Douglass, Joseph C. Madara, Miriam C. McDonough, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” Cell Reports. Cell Press, 2026. https://doi.org/10.1016/j.celrep.2025.116904. ieee: Y. Li et al., “A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types,” Cell Reports, vol. 45, no. 2. Cell Press, 2026. ista: Li Y, Butler TC, Nardone S, Jacobs CL, Douglass AM, Madara JC, McDonough MC, Tao J, Lowenstein ED, Wang L, Pant D, Walker SJ, Wang A, Srinivasan H, Yang Z, Campbell JN, Tsai LT, Lowell BB, Resch JM. 2026. A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types. Cell Reports. 45(2), 116904. mla: Li, Yuxi, et al. “A Spatial and Projection-Based Transcriptomic Atlas of Paraventricular Hypothalamic Cell Types.” Cell Reports, vol. 45, no. 2, 116904, Cell Press, 2026, doi:10.1016/j.celrep.2025.116904. short: Y. Li, T.C. Butler, S. Nardone, C.L. Jacobs, A.M. Douglass, J.C. Madara, M.C. McDonough, J. Tao, E.D. Lowenstein, L. Wang, D. Pant, S.J. Walker, A. Wang, H. Srinivasan, Z. Yang, J.N. Campbell, L.T. Tsai, B.B. Lowell, J.M. Resch, Cell Reports 45 (2026). date_created: 2026-04-16T13:51:29Z date_published: 2026-02-24T00:00:00Z date_updated: 2026-10-20T08:58:10Z day: '24' ddc: - '570' department: - _id: AmDo doi: 10.1016/j.celrep.2025.116904 external_id: pmid: - '41581146' file: - access_level: open_access checksum: 82098dd9d0ca609119f9f2c6beb4fc1e content_type: application/pdf creator: dernst date_created: 2026-05-04T11:58:51Z date_updated: 2026-05-04T11:58:51Z file_id: '21793' file_name: 2026_CellReports_Li.pdf file_size: 38532865 relation: main_file success: 1 file_date_updated: 2026-05-04T11:58:51Z fulldoi: https://doi.org/10.1016/j.celrep.2025.116904 has_accepted_license: '1' intvolume: ' 45' issue: '2' language: - iso: eng month: '02' oa: 1 oa_version: Published Version pmid: 1 publication: Cell Reports publication_identifier: eissn: - 2211-1247 issn: - 2639-1856 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: A spatial and projection-based transcriptomic atlas of paraventricular hypothalamic cell types tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 45 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21490' abstract: - lang: eng text: Auxin canalization is a self-organizing process that governs the flexible formation of vasculature by reinforcing the formation of auxin transport channels. A key prerequisite is the feedback between auxin signaling and directional auxin transport, mediated by PIN transporters. Despite the developmental importance of canalization, the molecular components linking auxin perception to the regulation of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel and essential component of auxin canalization that links intracellular auxin signaling with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23 transcriptional auxin signaling. tow mutants exhibit defects in regeneration and de novo vasculature formation, along with impaired formation of polarized, PIN-expressing auxin channels. At the subcellular level, these mutants display disrupted auxin-induced PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes predominantly to the plasma membrane, where it interacts with receptor-like kinases involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at the cell surface. Together, our findings identify TOW as a molecular link between intracellular and cell surface auxin signaling mechanisms that converge on PIN trafficking and polarity, providing new insights into how auxin signaling regulates directional auxin transport for the self-organizing formation of vasculature during flexible plant development. acknowledged_ssus: - _id: MassSpec - _id: Bio - _id: LifeSc acknowledgement: We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9 system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof. Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions, and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging & Optics Facility, and the Lab Support Facility at the Institute of Science and Technology Austria. This research was supported by the Scientific Service Units (SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF) and the Lab Support Facility (LSF). The work conducted by the Friml group was funded by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS) and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant Sciences Core Facility of CEITEC Masaryk University. E.M. received support from the National Science Centre (NCN), Poland, through the OPUS call within the Weave programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes Amos Comenius. article_processing_charge: Yes (via OA deal) article_type: original author: - first_name: Mingyue full_name: Li, Mingyue id: 01f96916-0235-11eb-9379-a323192643b7 last_name: Li - first_name: Nikola full_name: Rydza, Nikola last_name: Rydza - first_name: Ewa full_name: Mazur, Ewa last_name: Mazur - first_name: Gergely full_name: Molnar, Gergely id: 34F1AF46-F248-11E8-B48F-1D18A9856A87 last_name: Molnar - first_name: Tomasz full_name: Nodzyński, Tomasz last_name: Nodzyński - first_name: Jiří full_name: Friml, Jiří id: 4159519E-F248-11E8-B48F-1D18A9856A87 last_name: Friml orcid: 0000-0002-8302-7596 citation: ama: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 2026;36(6):1468-1480.e6. doi:10.1016/j.cub.2026.02.023 apa: Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., & Friml, J. (2026). Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2026.02.023 chicago: Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński, and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2026.02.023. ieee: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization,” Current Biology, vol. 36, no. 6. Cell Press, p. 1468–1480.e6, 2026. ista: Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 36(6), 1468–1480.e6. mla: Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” Current Biology, vol. 36, no. 6, Cell Press, 2026, p. 1468–1480.e6, doi:10.1016/j.cub.2026.02.023. short: M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology 36 (2026) 1468–1480.e6. corr_author: '1' date_created: 2026-03-23T15:11:16Z date_published: 2026-03-23T00:00:00Z date_updated: 2026-10-20T08:57:40Z day: '23' ddc: - '580' department: - _id: JiFr doi: 10.1016/j.cub.2026.02.023 external_id: pmid: - '41831441' file: - access_level: open_access checksum: fe6c41fdab58a55df5f2a5860c02acdc content_type: application/pdf creator: dernst date_created: 2026-03-24T08:34:37Z date_updated: 2026-03-24T08:34:37Z file_id: '21496' file_name: 2026_CurrentBiology_Li.pdf file_size: 12986894 relation: main_file success: 1 file_date_updated: 2026-03-24T08:34:37Z fulldoi: https://doi.org/10.1016/j.cub.2026.02.023 has_accepted_license: '1' intvolume: ' 36' issue: '6' language: - iso: eng month: '03' oa: 1 oa_version: Published Version page: 1468-1480.e6 pmid: 1 project: - _id: 8f347782-16d5-11f0-9cad-8c19706ee739 grant_number: '101142681' name: Cyclic nucleotides as second messengers in plants - _id: bd906599-d553-11ed-ba76-abf8547645d7 grant_number: E271 name: Identification of a novel regulator in auxin canalization publication: Current Biology publication_identifier: issn: - 0960-9822 publication_status: published publisher: Cell Press quality_controlled: '1' status: public title: Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- OA_place: publisher OA_type: hybrid PlanS_conform: '1' _id: '21509' abstract: - lang: eng text: Chromatin remodeling complexes mobilize nucleosomes and promote transcription factor (TF) binding. Using ensemble and single-molecule assays combined with cryo-electron microscopy (cryo-EM), we studied the interaction between pioneer TFs OCT4–SOX2 and the human BRG1/BRM-associated factor (BAF) complex on nucleosomes. BAF engages TF-bound substrates in two orientations, placing OCT4–SOX2 at either the remodeler ENTRY or EXIT site. At the ENTRY site, OCT4–SOX2 initially coexists with BAF without structural interference. However, continued DNA translocation is expected to cause collisions with bound TFs, which can trigger remodeling direction reversals or may induce TF dissociation. To accommodate TFs at the EXIT site, BAF undergoes structural rearrangements, and ensemble assays reveal a nucleosome subpopulation translocating away from TF-binding sites. Moreover, single-molecule experiments show that nucleosome-bound BAF frequently changes remodeling direction, and we identify an ADP-bound remodeler conformation as a potential intermediate. Together, these findings reveal key aspects of the conformational dynamics and remodeling outcomes underlying BAF processing of TF-bound nucleosomes. acknowledgement: We thank D. Hess, V. Iesmantavicius, and J. Seebacher (FMI Proteomics and Protein Analysis Facility) for mass spectrometry support; S. Smallwood, K. Shimada, D. Klein, and M. Schütz-Stoffregen for technical assistance; J. Côté and C. Lachance for critical discussions; and members of the Thomä lab for helpful feedback. Support for this work was provided to N.H.T. by the European Research Council under the European Union’s Horizon 2020 research program (NucEM, no. 884331), the Novartis Research Foundation, the Swiss National Science Foundation (SNF 31003A_179541, 310030_214852, and Sinergia CRSII5_186230), and the Swiss Cancer Research (KFS-4980-02-2020 and KFS-5933-08-2023). S.D. was supported by the European Research Council (DONUTS, no. 101092623), the Knut and Alice Wallenberg Foundation (2024.0012), the Cancerfonden (25 4453 Pj), and the Swedish Research Council (VR 03255). A.K.M. was supported by a Human Frontier Science Program Long-Term Fellowship, and L.V. was supported by an EMBO fellowship (ALTF 549-2021). article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Joscha full_name: Weiss, Joscha last_name: Weiss - first_name: Luca full_name: Vecchia, Luca last_name: Vecchia - first_name: David full_name: Domjan, David last_name: Domjan - first_name: Simone full_name: Cavadini, Simone last_name: Cavadini - first_name: Anton full_name: Sabantsev, Anton last_name: Sabantsev - first_name: Georg full_name: Kempf, Georg last_name: Kempf - first_name: Ganesh R. full_name: Pathare, Ganesh R. last_name: Pathare - first_name: Klaus full_name: Brackmann, Klaus last_name: Brackmann - first_name: Alicia full_name: Michael, Alicia id: 6437c950-2a03-11ee-914d-d6476dd7b75c last_name: Michael orcid: 0000-0002-6080-839X - first_name: Lukas full_name: Kater, Lukas last_name: Kater - first_name: Eric full_name: Hietter-Pfeiffer, Eric last_name: Hietter-Pfeiffer - first_name: Mina full_name: Haddawi, Mina last_name: Haddawi - first_name: Urja P. full_name: Kuber, Urja P. last_name: Kuber - first_name: Sandra full_name: Mühlhäusser, Sandra last_name: Mühlhäusser - first_name: Ralph S. full_name: Grand, Ralph S. last_name: Grand - first_name: Michael B. full_name: Stadler, Michael B. last_name: Stadler - first_name: Sebastian full_name: Deindl, Sebastian last_name: Deindl - first_name: Nicolas H. full_name: Thomä, Nicolas H. last_name: Thomä citation: ama: Weiss J, Vecchia L, Domjan D, et al. The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. 2026;86(4):625-639.e8. doi:10.1016/j.molcel.2026.01.021 apa: Weiss, J., Vecchia, L., Domjan, D., Cavadini, S., Sabantsev, A., Kempf, G., … Thomä, N. H. (2026). The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. Cell Press. https://doi.org/10.1016/j.molcel.2026.01.021 chicago: Weiss, Joscha, Luca Vecchia, David Domjan, Simone Cavadini, Anton Sabantsev, Georg Kempf, Ganesh R. Pathare, et al. “The Human BAF Chromatin Remodeler Processes Nucleosomes Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell. Cell Press, 2026. https://doi.org/10.1016/j.molcel.2026.01.021. ieee: J. Weiss et al., “The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2,” Molecular Cell, vol. 86, no. 4. Cell Press, p. 625–639.e8, 2026. ista: Weiss J, Vecchia L, Domjan D, Cavadini S, Sabantsev A, Kempf G, Pathare GR, Brackmann K, Michael AK, Kater L, Hietter-Pfeiffer E, Haddawi M, Kuber UP, Mühlhäusser S, Grand RS, Stadler MB, Deindl S, Thomä NH. 2026. The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2. Molecular Cell. 86(4), 625–639.e8. mla: Weiss, Joscha, et al. “The Human BAF Chromatin Remodeler Processes Nucleosomes Bound by Pioneer Transcription Factors OCT4–SOX2.” Molecular Cell, vol. 86, no. 4, Cell Press, 2026, p. 625–639.e8, doi:10.1016/j.molcel.2026.01.021. short: J. Weiss, L. Vecchia, D. Domjan, S. Cavadini, A. Sabantsev, G. Kempf, G.R. Pathare, K. Brackmann, A.K. Michael, L. Kater, E. Hietter-Pfeiffer, M. Haddawi, U.P. Kuber, S. Mühlhäusser, R.S. Grand, M.B. Stadler, S. Deindl, N.H. Thomä, Molecular Cell 86 (2026) 625–639.e8. date_created: 2026-03-30T11:58:48Z date_published: 2026-02-19T00:00:00Z date_updated: 2026-10-20T08:57:55Z day: '19' ddc: - '570' department: - _id: AlMi doi: 10.1016/j.molcel.2026.01.021 external_id: pmid: - '41679301' file: - access_level: open_access checksum: e16a7315b64a706184b177ea1621523c content_type: application/pdf creator: dernst date_created: 2026-03-30T12:04:38Z date_updated: 2026-03-30T12:04:38Z file_id: '21510' file_name: 2026_MolecularCell_Weiss.pdf file_size: 9786677 relation: main_file success: 1 file_date_updated: 2026-03-30T12:04:38Z fulldoi: https://doi.org/10.1016/j.molcel.2026.01.021 has_accepted_license: '1' intvolume: ' 86' issue: '4' language: - iso: eng month: '02' oa: 1 oa_version: Published Version page: 625-639.e8 pmid: 1 publication: Molecular Cell publication_identifier: issn: - 1097-2765 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: The human BAF chromatin remodeler processes nucleosomes bound by pioneer transcription factors OCT4–SOX2 tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 86 year: '2026' ... --- OA_place: publisher OA_type: hybrid _id: '21761' abstract: - lang: eng text: Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure. acknowledgement: S.B. acknowledges support from the National Institutes of Health (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G. acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society (RG\R2\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028. F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros). article_processing_charge: Yes (in subscription journal) article_type: original author: - first_name: Fernanda L full_name: Perez Verdugo, Fernanda L id: 4ecec223-9070-11ef-a0a9-bc76077bea8d last_name: Perez Verdugo - first_name: Eirini full_name: Maniou, Eirini last_name: Maniou - first_name: Gabriel L. full_name: Galea, Gabriel L. last_name: Galea - first_name: Shiladitya full_name: Banerjee, Shiladitya last_name: Banerjee citation: ama: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 2026;36(8):1903-1917.e5. doi:10.1016/j.cub.2026.02.068 apa: Perez Verdugo, F. L., Maniou, E., Galea, G. L., & Banerjee, S. (2026). Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2026.02.068 chicago: Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology. Cell Press, 2026. https://doi.org/10.1016/j.cub.2026.02.068. ieee: F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,” Current Biology, vol. 36, no. 8. Cell Press, p. 1903–1917.e5, 2026. ista: Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 36(8), 1903–1917.e5. mla: Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” Current Biology, vol. 36, no. 8, Cell Press, 2026, p. 1903–1917.e5, doi:10.1016/j.cub.2026.02.068. short: F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36 (2026) 1903–1917.e5. date_created: 2026-04-26T22:01:46Z date_published: 2026-04-20T00:00:00Z date_updated: 2026-10-20T08:59:48Z day: '20' ddc: - '570' department: - _id: AnSa doi: 10.1016/j.cub.2026.02.068 external_id: pmid: - '41881011' file: - access_level: open_access checksum: 80ae45457b4682c50c84f54de15aa9a8 content_type: application/pdf creator: dernst date_created: 2026-04-28T13:13:40Z date_updated: 2026-04-28T13:13:40Z file_id: '21774' file_name: 2026_CurrentBiology_PerezVerdugo.pdf file_size: 13402043 relation: main_file success: 1 file_date_updated: 2026-04-28T13:13:40Z fulldoi: https://doi.org/10.1016/j.cub.2026.02.068 has_accepted_license: '1' intvolume: ' 36' issue: '8' language: - iso: eng month: '04' oa: 1 oa_version: Published Version page: 1903-1917.e5 pmid: 1 publication: Current Biology publication_identifier: eissn: - 1879-0445 issn: - 0960-9822 publication_status: published publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis tmp: image: /images/cc_by_nc_nd.png legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) short: CC BY-NC-ND (4.0) type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 36 year: '2026' ... --- OA_place: repository OA_type: green _id: '21955' abstract: - lang: eng text: 'AgRP neurons cause hunger, the drive to seek and consume food. Their activation by fasting is key for survival and is thought to be triggered by feedback when energy stores are low. However, we know that environmental cues can also regulate AgRP neurons since cues that predict future food intake rapidly inhibit AgRP neurons, but is the converse true: can the prediction of future fasting rapidly activate AgRP neurons? Here, we show in mice that such rapid fasting activation of AgRP neurons does occur. This rapid activation is driven by excitatory input from paraventricular hypothalamic (PVH) neurons expressing Sim2, which are bidirectionally sensitive to predictions of future energy state. Thus, cognitively processed contextual information conveyed by PVHSim2 neurons strongly activates AgRP neurons. Lastly, chronic silencing of PVHSim2 neurons causes persistent hypophagia. This PVHSim2-to-AgRP-neuron circuit, by anticipating and preventing negative energy balance, provides an important new dimension of hunger regulation.' acknowledgement: "We thank all members of the B.B.L. laboratory for helpful discussions. We\r\nthank the BADERC and BNORC transgenic cores (NIH P30DK057521 and\r\nP30DK046200) for performing embryo injections to generate knockin mouse\r\nlines. We also thank the BIDMC Energy Balance Core (supported by NIH\r\nS10OD028635 and the Boston Area Diabetes Endocrinology Research Centers, P30DK135043), where Marissa Cortopassi performed indirect calorimetry experiments and Alexander Banks assisted with data analysis and interpretation. Confocal imaging was performed at BIDMC’s Confocal Imaging\r\nCore. We thank Chen Wu for assistance in designing knockin mouse lines.\r\nThis work was supported by the NIH (R01DK134427, R01DK096010, and\r\nR01DK075632 to B.B.L.). Authors were supported by an EMBO Long-Term\r\nFellowship (770-2018, S.J.W.), a T32 Postdoctoral Training Fellowship\r\n(5T32DK007516, E.D.L.), the Charles A. King Trust Postdoctoral Research\r\nFellowship program (A.M.D.), and a K99 Career Development Award\r\n(K99HL144923, J.M.R.)." article_processing_charge: No article_type: original author: - first_name: Samuel J. full_name: Walker, Samuel J. last_name: Walker - first_name: Elijah D. full_name: Lowenstein, Elijah D. last_name: Lowenstein - first_name: Amelia May Barnett full_name: Douglass, Amelia May Barnett id: de5f6fda-80fb-11ef-996f-a8c4ecd8e289 last_name: Douglass orcid: 0000-0001-5398-6473 - first_name: Callum M.P. full_name: Thomas, Callum M.P. last_name: Thomas - first_name: Joseph C. full_name: Madara, Joseph C. last_name: Madara - first_name: Hakan full_name: Kucukdereli, Hakan last_name: Kucukdereli - first_name: Eunice A. full_name: Barbosa-Meillon, Eunice A. last_name: Barbosa-Meillon - first_name: Jenkang full_name: Tao, Jenkang last_name: Tao - first_name: Jon M. full_name: Resch, Jon M. last_name: Resch - first_name: Bradford B. full_name: Lowell, Bradford B. last_name: Lowell citation: ama: Walker SJ, Lowenstein ED, Douglass AM, et al. A hypothalamic circuit for anticipating future changes in energy balance. Neuron. doi:10.1016/j.neuron.2026.05.010 apa: Walker, S. J., Lowenstein, E. D., Douglass, A. M., Thomas, C. M. P., Madara, J. C., Kucukdereli, H., … Lowell, B. B. (n.d.). A hypothalamic circuit for anticipating future changes in energy balance. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2026.05.010 chicago: Walker, Samuel J., Elijah D. Lowenstein, Amelia M. Douglass, Callum M.P. Thomas, Joseph C. Madara, Hakan Kucukdereli, Eunice A. Barbosa-Meillon, Jenkang Tao, Jon M. Resch, and Bradford B. Lowell. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” Neuron. Cell Press, n.d. https://doi.org/10.1016/j.neuron.2026.05.010. ieee: S. J. Walker et al., “A hypothalamic circuit for anticipating future changes in energy balance,” Neuron. Cell Press. ista: Walker SJ, Lowenstein ED, Douglass AM, Thomas CMP, Madara JC, Kucukdereli H, Barbosa-Meillon EA, Tao J, Resch JM, Lowell BB. A hypothalamic circuit for anticipating future changes in energy balance. Neuron. mla: Walker, Samuel J., et al. “A Hypothalamic Circuit for Anticipating Future Changes in Energy Balance.” Neuron, Cell Press, doi:10.1016/j.neuron.2026.05.010. short: S.J. Walker, E.D. Lowenstein, A.M. Douglass, C.M.P. Thomas, J.C. Madara, H. Kucukdereli, E.A. Barbosa-Meillon, J. Tao, J.M. Resch, B.B. Lowell, Neuron (n.d.). date_created: 2026-06-08T09:24:25Z date_published: 2026-06-03T00:00:00Z date_updated: 2026-10-20T09:00:02Z day: '03' department: - _id: AmDo doi: 10.1016/j.neuron.2026.05.010 external_id: pmid: - '42235510' fulldoi: https://doi.org/10.1016/j.neuron.2026.05.010 keyword: - hunger - hypothalamus - AGRP neurons - neuroscience - metabolism - homeostasis - feeding - food intake - energy balance - appetite language: - iso: eng main_file_link: - open_access: '1' url: https://doi.org/10.1101/2025.09.27.678865 month: '06' oa: 1 oa_version: Preprint pmid: 1 publication: Neuron publication_identifier: eissn: - ' 1097-4199' issn: - 0896-6273 publication_status: inpress publisher: Cell Press quality_controlled: '1' scopus_import: '1' status: public title: A hypothalamic circuit for anticipating future changes in energy balance type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2026' ... --- OA_type: closed access _id: '22144' abstract: - lang: eng text: Most cells polarize and migrate in response to electrical fields. In this issue of Cell, Belliveau et al. identify TMEM154/Galvanin, a receptor that serves as a cellular antenna to sense electrical gradients and guide migration toward the cathode. article_processing_charge: No article_type: comment author: - first_name: Michael full_name: Riedl, Michael id: 3BE60946-F248-11E8-B48F-1D18A9856A87 last_name: Riedl orcid: 0000-0003-4844-6311 - first_name: Michael K full_name: Sixt, Michael K id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87 last_name: Sixt orcid: 0000-0002-6620-9179 citation: ama: Riedl M, Sixt MK. A new sense for electrical fields. Cell. 2026;189(13):3845-3846. doi:10.1016/j.cell.2026.05.038 apa: Riedl, M., & Sixt, M. K. (2026). A new sense for electrical fields. Cell. Cell Press. https://doi.org/10.1016/j.cell.2026.05.038 chicago: Riedl, Michael, and Michael K Sixt. “A New Sense for Electrical Fields.” Cell. Cell Press, 2026. https://doi.org/10.1016/j.cell.2026.05.038. ieee: M. Riedl and M. K. Sixt, “A new sense for electrical fields,” Cell, vol. 189, no. 13. Cell Press, pp. 3845–3846, 2026. ista: Riedl M, Sixt MK. 2026. A new sense for electrical fields. Cell. 189(13), 3845–3846. mla: Riedl, Michael, and Michael K. Sixt. “A New Sense for Electrical Fields.” Cell, vol. 189, no. 13, Cell Press, 2026, pp. 3845–46, doi:10.1016/j.cell.2026.05.038. short: M. Riedl, M.K. Sixt, Cell 189 (2026) 3845–3846. corr_author: '1' das_tickbox: '0' date_created: 2026-06-28T22:01:34Z date_published: 2026-06-25T00:00:00Z date_updated: 2026-10-20T09:00:16Z day: '25' department: - _id: MiSi doi: 10.1016/j.cell.2026.05.038 fulldoi: https://doi.org/10.1016/j.cell.2026.05.038 intvolume: ' 189' issue: '13' language: - iso: eng month: '06' oa_version: None page: 3845-3846 publication: Cell publication_identifier: eissn: - 1097-4172 issn: - 0092-8674 publication_status: published publisher: Cell Press quality_controlled: '1' researchdata_availability: no scopus_import: '1' status: public supplementarymaterial: no title: A new sense for electrical fields type: journal_article user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 volume: 189 year: '2026' ...