---
_id: '3474'
abstract:
- lang: eng
text: 1. Excitatory postsynaptic currents (EPSCs) were recorded in CA3 pyramidal
cells of hippocampal slices of 15- to 24-day-old rats (22 degrees C) using the
whole-cell configuration of the patch clamp technique. 2. Composite EPSCs were
evoked by extracellular stimulation of the mossy fibre tract. Using the selective
blockers 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and D-2-amino-5-phosphonopentanoic
acid (APV), a major alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA)/kainate
receptor-mediated component and a minor NMDA receptor-mediated component with
slower time course were distinguished. For the AMPA/kainate receptor-mediated
component, the peak current-voltage (I-V) relation was linear, with a reversal
potential close to 0 mV. The half-maximal blocking concentration of CNQX was 353
nM. 3. Unitary EPSCs of the mossy fibre terminal (MF)-CA3 pyramidal cell synapse
were evoked at membrane potentials of -70 to -90 mV by low-intensity extracellular
stimulation of granule cell somata using fine-tipped pipettes. The EPSC peak amplitude
as a function of stimulus intensity showed all-or-none behaviour. The region of
low threshold was restricted to a few micrometres. This suggests that extracellular
stimulation was focal, and that the stimulus-evoked EPSCs were unitary. 4. Latency
and rise time histograms of EPSCs evoked by granule cell stimulation showed narrow
unimodal distributions within each experiment. The mean latency was 4.2 +/- 1.0
ms, and the mean 20-80% rise time was 0.6 +/- 0.1 ms (23 cells). When fitted within
the range 0.7 ms to 20 ms after the peak, the decay of the EPSCs with the fastest
rise (rise time 0.5 ms or less) could be described by a single exponential function;
the mean time constant was in the range 3.0-6.6 ms with a mean of 4.8 ms (8 cells).
5. Peak amplitudes of the EPSCs evoked by suprathreshold granule cell stimulation
fluctuated between trials. The apparent EPSC peak conductance in normal extracellular
solution (2 mM Ca2+, 1 mM Mg2+), excluding failures, was 1 nS. Reducing the Ca2+
concentration and increasing the Mg2+ concentration reduced the mean peak amplitude
in a concentration-dependent manner. 6. Peaks in EPSC peak amplitude distributions
were apparent in low Ca2+ and high Mg2+. Using the criteria of equidistance and
the presence of peaks and dips in the autocorrelation function, five of nine EPSC
peak amplitude distributions were judged to be quantal.
acknowledgement: "We are indebted to Professor B. Katz for critically reading the
manuscript and for helpful suggestions. We especially thank Professor D. Colquhoun
for several discussions, for generously providing the source codes of programs for
maximum-likelihood fit with sums of Gaussian functions, a routine for calculating
the error function and for critically reading the manuscript. We also thank Drs
A. Larkman, P. Ruppersberg, N. Spuston and G. Stuart for critically reading the
manuscript, P. Andersen, B. Betz, J. Evans, K. Harris, E. v. Kitzing, R. Rahamimov
and K. Stratford for helpful discussions, and J. J. B. Jack for much-needed advice
and guidance to G.M. We thank K. Bauer, F. Helmchen, M. Huke, B. Manz and especially
A. Roth for computer programming, B. Werner for typing the manuscript, and M. Kaiser
for excellent technical assistance. Part of the project was supported by the Deutsche
Forschungsgemeinschaft (SFB-317)\r\nand the Wellcome Trust."
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Guy
full_name: Major, Guy
last_name: Major
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Jonas PM, Major G, Sakmann B. Quantal components of unitary EPSCs at the mossy
fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of Physiology.
1993;472:615-663. doi:10.1113/jphysiol.1993.sp019965
apa: Jonas, P. M., Major, G., & Sakmann, B. (1993). Quantal components of unitary
EPSCs at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal
of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1993.sp019965
chicago: Jonas, Peter M, Guy Major, and Bert Sakmann. “Quantal Components of Unitary
EPSCs at the Mossy Fibre Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” Journal
of Physiology. Wiley-Blackwell, 1993. https://doi.org/10.1113/jphysiol.1993.sp019965.
ieee: P. M. Jonas, G. Major, and B. Sakmann, “Quantal components of unitary EPSCs
at the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus,” Journal
of Physiology, vol. 472. Wiley-Blackwell, pp. 615–663, 1993.
ista: Jonas PM, Major G, Sakmann B. 1993. Quantal components of unitary EPSCs at
the mossy fibre synapse on CA3 pyramidal cells of rat hippocampus. Journal of
Physiology. 472, 615–663.
mla: Jonas, Peter M., et al. “Quantal Components of Unitary EPSCs at the Mossy Fibre
Synapse on CA3 Pyramidal Cells of Rat Hippocampus.” Journal of Physiology,
vol. 472, Wiley-Blackwell, 1993, pp. 615–63, doi:10.1113/jphysiol.1993.sp019965.
short: P.M. Jonas, G. Major, B. Sakmann, Journal of Physiology 472 (1993) 615–663.
date_created: 2018-12-11T12:03:31Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-30T09:33:19Z
day: '01'
doi: 10.1113/jphysiol.1993.sp019965
extern: '1'
external_id:
pmid:
- '7908327'
intvolume: ' 472'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1160505
month: '12'
oa: 1
oa_version: Published Version
page: 615 - 663
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2913'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantal components of unitary EPSCs at the mossy fibre synapse on CA3 pyramidal
cells of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 472
year: '1993'
...
---
_id: '4041'
abstract:
- lang: eng
text: The zone theorem for an arrangement of n hyperplanes in d-dimensional real
space says that the total number of faces bounding the cells intersected by another
hyperplane is O(n(d-1)). This result is the basis of a time-optimal incremental
algorithm that constructs a hyperplane arrangement and has a host of other algorithmic
and combinatorial applications. Unfortunately, the original proof of the zone
theorem, for d greater-than-or-equal-to 3, turned out to contain a serious and
irreparable error. This paper presents a new proof of the theorem. The proof is
based on an inductive argument, which also applies in the case of pseudohyperplane
arrangements. The fallacies of the old proof along with some ways of partially
saving that approach are briefly discussed.
acknowledgement: National Science Foundation under grant CCR-89- 21421.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Raimund
full_name: Seidel, Raimund
last_name: Seidel
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Edelsbrunner H, Seidel R, Sharir M. On the zone theorem for hyperplane arrangements.
SIAM Journal on Computing. 1993;22(2):418-429. doi:10.1137/0222031
apa: Edelsbrunner, H., Seidel, R., & Sharir, M. (1993). On the zone theorem
for hyperplane arrangements. SIAM Journal on Computing. SIAM. https://doi.org/10.1137/0222031
chicago: Edelsbrunner, Herbert, Raimund Seidel, and Micha Sharir. “On the Zone Theorem
for Hyperplane Arrangements.” SIAM Journal on Computing. SIAM, 1993. https://doi.org/10.1137/0222031.
ieee: H. Edelsbrunner, R. Seidel, and M. Sharir, “On the zone theorem for hyperplane
arrangements,” SIAM Journal on Computing, vol. 22, no. 2. SIAM, pp. 418–429,
1993.
ista: Edelsbrunner H, Seidel R, Sharir M. 1993. On the zone theorem for hyperplane
arrangements. SIAM Journal on Computing. 22(2), 418–429.
mla: Edelsbrunner, Herbert, et al. “On the Zone Theorem for Hyperplane Arrangements.”
SIAM Journal on Computing, vol. 22, no. 2, SIAM, 1993, pp. 418–29, doi:10.1137/0222031.
short: H. Edelsbrunner, R. Seidel, M. Sharir, SIAM Journal on Computing 22 (1993)
418–429.
date_created: 2018-12-11T12:06:35Z
date_published: 1993-04-01T00:00:00Z
date_updated: 2022-03-29T13:25:02Z
day: '01'
doi: 10.1137/0222031
extern: '1'
intvolume: ' 22'
issue: '2'
language:
- iso: eng
main_file_link:
- url: https://epubs.siam.org/doi/10.1137/0222031
month: '04'
oa_version: None
page: 418 - 429
publication: SIAM Journal on Computing
publication_identifier:
issn:
- 0097-5397
publication_status: published
publisher: SIAM
publist_id: '2085'
quality_controlled: '1'
scopus_import: '1'
status: public
title: On the zone theorem for hyperplane arrangements
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '1993'
...
---
_id: '4045'
abstract:
- lang: eng
text: We apply Megiddo's parametric searching technique to several geometric optimization
problems and derive significantly improved solutions for them. We obtain, for
any fixed ε>0, an O(n1+ε) algorithm for computing the diameter of a point set
in 3-space, an O(8/5+ε) algorithm for computing the width of such a set, and on
O(n8/5+ε) algorithm for computing the closest pair in a set of n lines in space.
All these algorithms are deterministic.
acknowledgement: '*Work by Bernard Chazelle was supported by NSF Grant CCR-90-02352.
Work by Herbert Edelsbrunner was supported by NSF Grant CCR-89-21421. Work by Leonidas
Guibas and Micha Sharir was supported by a grant from the U.S.-Israeli Binational
Science Foundation. Work by Micha Sharir was also supported by ONR Grant N00014-90-J-1284,
by NSF Grant CCR-89-01484, and by grants from the Fund for Basic Research administered
by the Israeli Academy of Sciences, and the G.I.F., the German-Israeli Foundation
for Scientific Research and Development.'
article_processing_charge: No
article_type: original
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. Diameter, width, closest line
pair, and parametric searching. Discrete & Computational Geometry.
1993;10(1):183-196. doi:10.1007/BF02573973
apa: Chazelle, B., Edelsbrunner, H., Guibas, L., & Sharir, M. (1993). Diameter,
width, closest line pair, and parametric searching. Discrete & Computational
Geometry. Springer. https://doi.org/10.1007/BF02573973
chicago: Chazelle, Bernard, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir.
“Diameter, Width, Closest Line Pair, and Parametric Searching.” Discrete &
Computational Geometry. Springer, 1993. https://doi.org/10.1007/BF02573973.
ieee: B. Chazelle, H. Edelsbrunner, L. Guibas, and M. Sharir, “Diameter, width,
closest line pair, and parametric searching,” Discrete & Computational
Geometry, vol. 10, no. 1. Springer, pp. 183–196, 1993.
ista: Chazelle B, Edelsbrunner H, Guibas L, Sharir M. 1993. Diameter, width, closest
line pair, and parametric searching. Discrete & Computational Geometry. 10(1),
183–196.
mla: Chazelle, Bernard, et al. “Diameter, Width, Closest Line Pair, and Parametric
Searching.” Discrete & Computational Geometry, vol. 10, no. 1, Springer,
1993, pp. 183–96, doi:10.1007/BF02573973.
short: B. Chazelle, H. Edelsbrunner, L. Guibas, M. Sharir, Discrete & Computational
Geometry 10 (1993) 183–196.
date_created: 2018-12-11T12:06:37Z
date_published: 1993-12-01T00:00:00Z
date_updated: 2022-03-28T14:50:42Z
day: '01'
doi: 10.1007/BF02573973
extern: '1'
intvolume: ' 10'
issue: '1'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF02573973
month: '12'
oa_version: None
page: 183 - 196
publication: Discrete & Computational Geometry
publication_identifier:
issn:
- 0179-5376
publication_status: published
publisher: Springer
publist_id: '2083'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diameter, width, closest line pair, and parametric searching
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 10
year: '1993'
...
---
_id: '4175'
abstract:
- lang: eng
text: We have studied the effects of different neurotrophins on the survival and
proliferation of rat cerebellar granule cells in culture. These neurons express
trkB and trkC, the putative neuronal receptors for brain-derived neurotrophic
factor (BDNF) and neurotrophin-3 (NT-3) respectively. Binding studies using iodinated
BDNF and NT-3 demonstrated that both BDNF and NT-3 bind to the cerebellar granule
neurons with a similar affinity of approximately 2 x 10(-9) M. The number of receptors
per granule cell was surprisingly high, approximately 30 x 10(-4) and 2 x 10(5)
for BDNF and NT-3, respectively. Both NT-3 and BDNF elevated c-fos mRNA in the
granule neurons, but only BDNF up-regulated the mRNA encoding the low-affinity
neurotrophin receptor (p75). In contrast to NT-3, BDNF acted as a survival factor
for the granule neurons. BDNF also induced sprouting of the granule neurons and
significantly protected them against neurotoxicity induced by high (1 mM) glutamate
concentrations. Cultured granule neurons also expressed low levels of BDNF mRNA
which were increased by kainic acid, a glutamate receptor agonist. Thus, BDNF,
but not NT-3, is a survival factor for cultured cerebellar granule neurons and
activation of glutamate receptor(s) up-regulates BDNF expression in these cells.
article_processing_charge: No
article_type: original
author:
- first_name: Dan
full_name: Lindholm, Dan
last_name: Lindholm
- first_name: Georg
full_name: Dechant, Georg
last_name: Dechant
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Hans
full_name: Thoenen, Hans
last_name: Thoenen
citation:
ama: Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. Brain-derived neurotrophic
factor is a survival factor for cultured rat cerebellar granule neurons and protects
them against glutamate-induced neurotoxicity. European Journal of Neuroscience.
1993;5(11):1455-1464. doi:10.1111/j.1460-9568.1993.tb00213.x
apa: Lindholm, D., Dechant, G., Heisenberg, C.-P. J., & Thoenen, H. (1993).
Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar
granule neurons and protects them against glutamate-induced neurotoxicity. European
Journal of Neuroscience. Wiley-Blackwell. https://doi.org/10.1111/j.1460-9568.1993.tb00213.x
chicago: Lindholm, Dan, Georg Dechant, Carl-Philipp J Heisenberg, and Hans Thoenen.
“Brain-Derived Neurotrophic Factor Is a Survival Factor for Cultured Rat Cerebellar
Granule Neurons and Protects Them against Glutamate-Induced Neurotoxicity.” European
Journal of Neuroscience. Wiley-Blackwell, 1993. https://doi.org/10.1111/j.1460-9568.1993.tb00213.x.
ieee: D. Lindholm, G. Dechant, C.-P. J. Heisenberg, and H. Thoenen, “Brain-derived
neurotrophic factor is a survival factor for cultured rat cerebellar granule neurons
and protects them against glutamate-induced neurotoxicity,” European Journal
of Neuroscience, vol. 5, no. 11. Wiley-Blackwell, pp. 1455–1464, 1993.
ista: Lindholm D, Dechant G, Heisenberg C-PJ, Thoenen H. 1993. Brain-derived neurotrophic
factor is a survival factor for cultured rat cerebellar granule neurons and protects
them against glutamate-induced neurotoxicity. European Journal of Neuroscience.
5(11), 1455–1464.
mla: Lindholm, Dan, et al. “Brain-Derived Neurotrophic Factor Is a Survival Factor
for Cultured Rat Cerebellar Granule Neurons and Protects Them against Glutamate-Induced
Neurotoxicity.” European Journal of Neuroscience, vol. 5, no. 11, Wiley-Blackwell,
1993, pp. 1455–64, doi:10.1111/j.1460-9568.1993.tb00213.x.
short: D. Lindholm, G. Dechant, C.-P.J. Heisenberg, H. Thoenen, European Journal
of Neuroscience 5 (1993) 1455–1464.
date_created: 2018-12-11T12:07:24Z
date_published: 1993-11-01T00:00:00Z
date_updated: 2022-03-28T13:33:18Z
day: '01'
doi: 10.1111/j.1460-9568.1993.tb00213.x
extern: '1'
external_id:
pmid:
- '7904521 '
intvolume: ' 5'
issue: '11'
language:
- iso: eng
main_file_link:
- url: https://onlinelibrary.wiley.com/doi/10.1111/j.1460-9568.1993.tb00213.x
month: '11'
oa_version: None
page: 1455 - 1464
pmid: 1
publication: European Journal of Neuroscience
publication_identifier:
issn:
- 0953-816X
publication_status: published
publisher: Wiley-Blackwell
publist_id: '1943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Brain-derived neurotrophic factor is a survival factor for cultured rat cerebellar
granule neurons and protects them against glutamate-induced neurotoxicity
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '1993'
...
---
_id: '4177'
abstract:
- lang: eng
text: Thyroid hormones play an important role in brain development, but the mechanism(s)
by which triiodothyronine (T3) mediates neuronal differentiation is poorly understood.
Here we demonstrate that T3 regulates the neurotrophic factor, neurotrophin-3
(NT-3), in developing rat cerebellar granule cells both in cell culture and in
vivo. In situ hybridization experiments showed that developing Purkinje cells
do not express NT-3 mRNA but do express trkC, the putative neuronal receptor for
NT-3. Addition of recombinant NT-3 to cerebellar cultures from embryonic rat brain
induces hypertrophy and neurite sprouting of Purkinje cells, and upregulates the
mRNA encoding the calcium-binding protein, calbindin-28 kD. The present study
demonstrates a novel interaction between cerebellar granule neurons and developing
Purkinje cells in which NT-3 induced by T3 in the granule cells promotes Purkinje
cell differentiation.
acknowledgement: "E. Castrtn is an Alexander von Humboldt fellow. M. Berzaghi is supported
by a scholarship from CNPQ, Brasil. L. F. Parada, P. Tsoulfas, and L. Tesarollo
were supported by a National Institutes of Health grant. We thank D. Stratmann and
K. Angermeyer for skillful technical assistance; I. Hajjar for secretarial work
and Dr. R. G~rtner for help with\r\ninducing hypothyroidism; Dr. W. Hunzieker for
the calbindin-28 kD eDNA; Dr. M. Fishman for the GAP-43 eDNA; and Dr. Y.-A. Barde
for critical comments."
article_processing_charge: No
article_type: original
author:
- first_name: Dan
full_name: Lindholm, Dan
last_name: Lindholm
- first_name: Eero
full_name: Castrén, Eero
last_name: Castrén
- first_name: Pantelis
full_name: Tsoulfas, Pantelis
last_name: Tsoulfas
- first_name: Roland
full_name: Kolbeck, Roland
last_name: Kolbeck
- first_name: Maria
full_name: Berzaghi, Maria
last_name: Berzaghi
- first_name: Axel
full_name: Leingärtner, Axel
last_name: Leingärtner
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Lino
full_name: Tesarollo, Lino
last_name: Tesarollo
- first_name: Luis
full_name: Parada, Luis
last_name: Parada
- first_name: Hans
full_name: Thoenen, Hans
last_name: Thoenen
citation:
ama: Lindholm D, Castrén E, Tsoulfas P, et al. Neurotrophin-3 induced by tri-iodothyronine
in cerebellar granule cells promotes Purkinje cell differentiation. Journal
of Cell Biology. 1993;122(2):443-450. doi:10.1083/jcb.122.2.443
apa: Lindholm, D., Castrén, E., Tsoulfas, P., Kolbeck, R., Berzaghi, M., Leingärtner,
A., … Thoenen, H. (1993). Neurotrophin-3 induced by tri-iodothyronine in cerebellar
granule cells promotes Purkinje cell differentiation. Journal of Cell Biology.
Rockefeller University Press. https://doi.org/10.1083/jcb.122.2.443
chicago: Lindholm, Dan, Eero Castrén, Pantelis Tsoulfas, Roland Kolbeck, Maria Berzaghi,
Axel Leingärtner, Carl-Philipp J Heisenberg, Lino Tesarollo, Luis Parada, and
Hans Thoenen. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar Granule
Cells Promotes Purkinje Cell Differentiation.” Journal of Cell Biology.
Rockefeller University Press, 1993. https://doi.org/10.1083/jcb.122.2.443.
ieee: D. Lindholm et al., “Neurotrophin-3 induced by tri-iodothyronine in
cerebellar granule cells promotes Purkinje cell differentiation,” Journal of
Cell Biology, vol. 122, no. 2. Rockefeller University Press, pp. 443–450,
1993.
ista: Lindholm D, Castrén E, Tsoulfas P, Kolbeck R, Berzaghi M, Leingärtner A, Heisenberg
C-PJ, Tesarollo L, Parada L, Thoenen H. 1993. Neurotrophin-3 induced by tri-iodothyronine
in cerebellar granule cells promotes Purkinje cell differentiation. Journal of
Cell Biology. 122(2), 443–450.
mla: Lindholm, Dan, et al. “Neurotrophin-3 Induced by Tri-Iodothyronine in Cerebellar
Granule Cells Promotes Purkinje Cell Differentiation.” Journal of Cell Biology,
vol. 122, no. 2, Rockefeller University Press, 1993, pp. 443–50, doi:10.1083/jcb.122.2.443.
short: D. Lindholm, E. Castrén, P. Tsoulfas, R. Kolbeck, M. Berzaghi, A. Leingärtner,
C.-P.J. Heisenberg, L. Tesarollo, L. Parada, H. Thoenen, Journal of Cell Biology
122 (1993) 443–450.
date_created: 2018-12-11T12:07:25Z
date_published: 1993-07-15T00:00:00Z
date_updated: 2022-03-24T12:59:20Z
day: '15'
doi: 10.1083/jcb.122.2.443
extern: '1'
external_id:
pmid:
- '8320266'
intvolume: ' 122'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119654/
month: '07'
oa: 1
oa_version: None
page: 443 - 450
pmid: 1
publication: Journal of Cell Biology
publication_identifier:
issn:
- 0021-9525
publication_status: published
publisher: Rockefeller University Press
publist_id: '1942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Neurotrophin-3 induced by tri-iodothyronine in cerebellar granule cells promotes
Purkinje cell differentiation
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 122
year: '1993'
...
---
_id: '4506'
abstract:
- lang: eng
text: We propose a formal framework for designing hybrid systems by stepwise refinement.
Starting with a specification in hybrid temporal logic, we make successively more
transitions explicit until we obtain an executable system.
acknowledgement: This research was supported in part by the National Science Foundation
under grants CCR-92-00794 and CCR-92-23226, by the Defense Advanced Research Projects
Agency under contract NAG2-703, by the United States Air Force Office of Scientific
Research under contracts F49620-93-1-0056 and F49620-93-1-0139, and by the European
Community ESPRIT Basic Research Action Project 6021 (REACT).
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Zohar
full_name: Manna, Zohar
last_name: Manna
- first_name: Amir
full_name: Pnueli, Amir
last_name: Pnueli
citation:
ama: 'Henzinger TA, Manna Z, Pnueli A. Towards refining temporal specifications
into hybrid systems. In: Grossman R, Nerode A, Ravn A, Rischel H, eds. International
Hybrid Systems Workshop. Vol 736. Springer; 1993:60-76. doi:10.1007/3-540-57318-6_24'
apa: Henzinger, T. A., Manna, Z., & Pnueli, A. (1993). Towards refining temporal
specifications into hybrid systems. In R. Grossman, A. Nerode, A. Ravn, &
H. Rischel (Eds.), International Hybrid Systems Workshop (Vol. 736, pp.
60–76). Springer. https://doi.org/10.1007/3-540-57318-6_24
chicago: Henzinger, Thomas A, Zohar Manna, and Amir Pnueli. “Towards Refining Temporal
Specifications into Hybrid Systems.” In International Hybrid Systems Workshop,
edited by Robert Grossman, Anil Nerode, Anders Ravn, and Hans Rischel, 736:60–76.
Springer, 1993. https://doi.org/10.1007/3-540-57318-6_24.
ieee: T. A. Henzinger, Z. Manna, and A. Pnueli, “Towards refining temporal specifications
into hybrid systems,” in International Hybrid Systems Workshop, 1993, vol.
736, pp. 60–76.
ista: Henzinger TA, Manna Z, Pnueli A. 1993. Towards refining temporal specifications
into hybrid systems. International Hybrid Systems Workshop. International Hybrid
Systems Workshop, LNCS, vol. 736, 60–76.
mla: Henzinger, Thomas A., et al. “Towards Refining Temporal Specifications into
Hybrid Systems.” International Hybrid Systems Workshop, edited by Robert
Grossman et al., vol. 736, Springer, 1993, pp. 60–76, doi:10.1007/3-540-57318-6_24.
short: T.A. Henzinger, Z. Manna, A. Pnueli, in:, R. Grossman, A. Nerode, A. Ravn,
H. Rischel (Eds.), International Hybrid Systems Workshop, Springer, 1993, pp.
60–76.
conference:
name: International Hybrid Systems Workshop
date_created: 2018-12-11T12:09:12Z
date_published: 1993-01-01T00:00:00Z
date_updated: 2022-03-23T13:13:46Z
day: '01'
doi: 10.1007/3-540-57318-6_24
editor:
- first_name: Robert
full_name: Grossman, Robert
last_name: Grossman
- first_name: Anil
full_name: Nerode, Anil
last_name: Nerode
- first_name: Anders
full_name: Ravn, Anders
last_name: Ravn
- first_name: Hans
full_name: Rischel, Hans
last_name: Rischel
extern: '1'
intvolume: ' 736'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-57318-6_24
month: '01'
oa_version: None
page: 60 - 76
publication: International Hybrid Systems Workshop
publication_identifier:
isbn:
- 978-3-540-57318-0
publication_status: published
publisher: Springer
publist_id: '225'
quality_controlled: '1'
status: public
title: Towards refining temporal specifications into hybrid systems
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 736
year: '1993'
...
---
_id: '2532'
abstract:
- lang: eng
text: In the present study, we have investigated the expression of both the erythrocyte-type
(GLUT1) and the brain-type (GLUT3) glucose transporter isoforms in primary human
brain tumors. In situ hybridization made it possible to localize and semiquantify
both GLUT1 and GLUT3 mRNAs of individual cells in all 18 samples examined. More
signals for GLUT3 mRNA than for GLUT1 mRNA were found over astrocytoma cells,
while the reverse was the case in all 6 meningiomas. In astrocytomas, for both
mRNAs, the density of silver grains over tumor cells was well correlated with
the malignancy of the cells. This correlation was, as was also confirmed by Northern
blot analysis, more marked with GLUT3 mRNA than with GLUT1 mRNA. In 2 of 5 anaplastic
astrocytomas and in all 3 glioblastomas, numerous tumor cells with large amounts
of both mRNAs tended to surround the perivascular regions. 'Tumor vessels' with
endothelial proliferation, an almost pathognomonic feature of glioblastomas, expressed
much GLUT3 mRNA but no significant GLUT1 mRNA, while a single- or a few-layered
capillary endothelium expressed much GLUT1 mRNA. The distribution of both mRNAs
was in good accordance with that of both proteins. Our results suggest that the
expression of both glucose transporter isoforms may contribute to the maintenance
of human brain tumors and that the expression of the GLUT3 isoform may be closely
related to the malignant change of astrocytomas and particularly related to the
aberrant neovascularization which accompanies glioblastomas.
acknowledgement: 'We wish to acknowledge generous donations of human samples by the
following neurosurgeons: Drs. Taro Fukumitsu. Akinori Kondo, Toyoshiro Yamamoto,
Juji Takeuchi, Junya Hanakita, Syunichi Yoneda, and Michio Nishikawa. We are very
grateful to Dr. G. I. Bell (The University of Chicago) for providing the cDNA clones
of GLUTI and GLUT3. We thank Drs. Yoshifumi Yokota, Yuichiro Yamada. and Manabu
Fukumoto for their helpful advice. We also thank Yoshinobu Toda and Hiroko Sato
for their expert technical assistance. Supported in part by Grants in Aids for Basic
Research on Radiation Therapy (03151034) and Special Project Research on Cancer
Bio-Science from the Ministry of Education, Science, and Culture of Japan, by Takeda
Medical Foundation, and by Monbusho International Scientific Research: Joint Research.'
article_processing_charge: No
article_type: original
author:
- first_name: Tatsuya
full_name: Nishioka, Tatsuya
last_name: Nishioka
- first_name: Yoshifumi
full_name: Oda, Yoshifumi
last_name: Oda
- first_name: Yutaka
full_name: Seino, Yutaka
last_name: Seino
- first_name: Taizo
full_name: Yamamoto, Taizo
last_name: Yamamoto
- first_name: Nobuya
full_name: Inagaki, Nobuya
last_name: Inagaki
- first_name: Hideki
full_name: Yano, Hideki
last_name: Yano
- first_name: Hiroo
full_name: Imura, Hiroo
last_name: Imura
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Haruhiko
full_name: Kikuchi, Haruhiko
last_name: Kikuchi
citation:
ama: Nishioka T, Oda Y, Seino Y, et al. Distribution of the glucose transporters
in human brain tumors. Cancer Research. 1992;52(14):3972-3979.
apa: Nishioka, T., Oda, Y., Seino, Y., Yamamoto, T., Inagaki, N., Yano, H., … Kikuchi,
H. (1992). Distribution of the glucose transporters in human brain tumors. Cancer
Research. American Association for Cancer Research.
chicago: Nishioka, Tatsuya, Yoshifumi Oda, Yutaka Seino, Taizo Yamamoto, Nobuya
Inagaki, Hideki Yano, Hiroo Imura, Ryuichi Shigemoto, and Haruhiko Kikuchi. “Distribution
of the Glucose Transporters in Human Brain Tumors.” Cancer Research. American
Association for Cancer Research, 1992.
ieee: T. Nishioka et al., “Distribution of the glucose transporters in human
brain tumors,” Cancer Research, vol. 52, no. 14. American Association for
Cancer Research, pp. 3972–3979, 1992.
ista: Nishioka T, Oda Y, Seino Y, Yamamoto T, Inagaki N, Yano H, Imura H, Shigemoto
R, Kikuchi H. 1992. Distribution of the glucose transporters in human brain tumors.
Cancer Research. 52(14), 3972–3979.
mla: Nishioka, Tatsuya, et al. “Distribution of the Glucose Transporters in Human
Brain Tumors.” Cancer Research, vol. 52, no. 14, American Association for
Cancer Research, 1992, pp. 3972–79.
short: T. Nishioka, Y. Oda, Y. Seino, T. Yamamoto, N. Inagaki, H. Yano, H. Imura,
R. Shigemoto, H. Kikuchi, Cancer Research 52 (1992) 3972–3979.
date_created: 2018-12-11T11:58:13Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T15:38:42Z
day: '01'
extern: '1'
external_id:
pmid:
- '1617673'
intvolume: ' 52'
issue: '14'
language:
- iso: eng
main_file_link:
- url: https://aacrjournals.org/cancerres/article/52/14/3972/497930/Distribution-of-the-Glucose-Transporters-in-Human
month: '01'
oa_version: None
page: 3972 - 3979
pmid: 1
publication: Cancer Research
publication_identifier:
issn:
- 0008-5472
publication_status: published
publisher: American Association for Cancer Research
publist_id: '4367'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Distribution of the glucose transporters in human brain tumors
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 52
year: '1992'
...
---
_id: '2533'
abstract:
- lang: eng
text: A cDNA clone for a new metabotropic glutamate receptor, mGluR5, was isolated
through polymerase chain reaction-mediated DNA amplification by using primer sequences
conserved among the metabotropic glutamate receptor (mGluR) family and by the
subsequent screening of a rat brain cDNA library. The cloned receptor consists
of 1171 amino acid residues and exhibits a structural architecture common to the
mGluR family, possessing a large extracellular domain preceding the seven putative
membrane-spanning segments. mGluR5 shows the highest sequence similarity to mGluR1
among the mGluR members and is coupled to the stimulation of phosphatidylinositol
hydrolysis/ Ca2+ signal transduction in Chinese hamster ovary cells transfected
with the cloned cDNA. This receptor also resembles mGluR1 in its agonist selectivity
and antagonist responses; the potency rank order of agonists for mGluR5 was determined
to be quisqualate > L-glutamate ≥ ibotenate > trans-1-aminocyclopentane-1,3-dicarboxylate.
Blot and in situ hybridization analyses indicated that mGluR5 mRNA is widely distributed
in neuronal cells of the central nervous system and is expressed differently from
mGluR1 mRNA in many brain regions. This investigation thus demonstrates that there
is an additional mGluR subtype which closely resembles mGluR1 in its signal transduction
and pharmacological properties and is expressed in specialized neuronal cells
in the central nervous system.
acknowledgement: We are grateful to Seiji Ito for help of Ca2+ measurements and Akira
Uesugi for photographic assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Hidemitsu
full_name: Sugihara, Hidemitsu
last_name: Sugihara
- first_name: Hiroyuki
full_name: Nawa, Hiroyuki
last_name: Nawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. Molecular characterization
of a novel metabotropic glutamate receptor mGluR5 coupled to inositol phosphate/Ca2+
signal transduction. Journal of Biological Chemistry. 1992;267(19):13361-13368.
doi:10.1016/S0021-9258(18)42219-3
apa: Abe, T., Sugihara, H., Nawa, H., Shigemoto, R., Mizuno, N., & Nakanishi,
S. (1992). Molecular characterization of a novel metabotropic glutamate receptor
mGluR5 coupled to inositol phosphate/Ca2+ signal transduction. Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1016/S0021-9258(18)42219-3
chicago: Abe, Takaaki, Hidemitsu Sugihara, Hiroyuki Nawa, Ryuichi Shigemoto, Noboru
Mizuno, and Shigetada Nakanishi. “Molecular Characterization of a Novel Metabotropic
Glutamate Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.”
Journal of Biological Chemistry. American Society for Biochemistry and
Molecular Biology, 1992. https://doi.org/10.1016/S0021-9258(18)42219-3.
ieee: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, and S. Nakanishi, “Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction,” Journal of Biological Chemistry,
vol. 267, no. 19. American Society for Biochemistry and Molecular Biology, pp.
13361–13368, 1992.
ista: Abe T, Sugihara H, Nawa H, Shigemoto R, Mizuno N, Nakanishi S. 1992. Molecular
characterization of a novel metabotropic glutamate receptor mGluR5 coupled to
inositol phosphate/Ca2+ signal transduction. Journal of Biological Chemistry.
267(19), 13361–13368.
mla: Abe, Takaaki, et al. “Molecular Characterization of a Novel Metabotropic Glutamate
Receptor MGluR5 Coupled to Inositol Phosphate/Ca2+ Signal Transduction.” Journal
of Biological Chemistry, vol. 267, no. 19, American Society for Biochemistry
and Molecular Biology, 1992, pp. 13361–68, doi:10.1016/S0021-9258(18)42219-3.
short: T. Abe, H. Sugihara, H. Nawa, R. Shigemoto, N. Mizuno, S. Nakanishi, Journal
of Biological Chemistry 267 (1992) 13361–13368.
date_created: 2018-12-11T11:58:14Z
date_published: 1992-07-05T00:00:00Z
date_updated: 2022-03-17T15:08:29Z
day: '05'
doi: 10.1016/S0021-9258(18)42219-3
extern: '1'
external_id:
pmid:
- '1320017'
intvolume: ' 267'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/S0021925818422193
month: '07'
oa: 1
oa_version: Published Version
page: 13361 - 13368
pmid: 1
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- 0021-9258
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '4366'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Molecular characterization of a novel metabotropic glutamate receptor mGluR5
coupled to inositol phosphate/Ca2+ signal transduction
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 267
year: '1992'
...
---
_id: '2535'
abstract:
- lang: eng
text: We report the molecular characterization of two novel rat helix-loop-helix
(HLH) proteins, designated HES-1 and HES-3, that show structural homology to the
Drosophila hairy and Enhancer of split [E(spl)] proteins, both of which are required
for normal neurogenesis. HES-1 mRNA, expressed in various tissues of both embryos
and adults, is present at a high level in the epithelial cells, including the
embryonal neuroepithelial cells, as well as in the mesoderm-derived tissues such
as the embryonal muscle. In contrast, HES-3 mRNA is produced exclusively in cerebellar
Purkinje cells. HES-1 represses transcription by binding to the N box, which is
a recognition sequence of E(spl) proteins. Interestingly, neither HES-1 nor HES-3
alone interacts efficiently with the E box, but each protein decreases the transcription
induced by E-box-binding HLH activators such as E47. Furthermore, HES-1 also inhibits
the functions of MyoD and MASH1 and effectively diminishes the myogenic conversion
of C3H10T1/2 cells induced by MyoD. These results suggest that HES-1 may play
an important role in mammalian development by negatively acting on the two different
sequences while HES-3 acts as a repressor in a specific type of neurons.
acknowledgement: "We thank Professor Noboru Mizuno for his kind help with in situ
hybridization experiments, Akira Uesugi and Dr. Chihiro\r\nAkazawa for photographic
assistance, Drs. Elizabeth Knust and Jose A. Campos-Ortega for communicating their
unpublished results, Dr. Shinji Fushiki for useful discussion, Dr. Mikio Nishizawa
and Professor Shigekazu Nagata for pMNT, Dr. David Baltimore for the E47 expression
vector, Drs. Yoichiro Nabeshima and Atsuko Fujisawa for the MyoD expression vector
and the reporter plasmid with the MCK enhancer, and Dr. Makoto Ishibashi for his
help in isolating the human E47 eDNA clone. This work was supported in part by research
grants from the Ministry of Education, Science, and Culture of Japan. The publication
costs of this article were defrayed in part by payment of page charges. This article
must therefore be hereby marked \"advertisement\" in accordance with 18 USC section
1734 solely to indicate this fact. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Yoshiki
full_name: Sasai, Yoshiki
last_name: Sasai
- first_name: Ryoichiro
full_name: Kageyama, Ryoichiro
last_name: Kageyama
- first_name: Yoshiaki
full_name: Tagawa, Yoshiaki
last_name: Tagawa
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. Two mammalian helix-loop-helix
factors structurally related to Drosophila hairy and Enhancer of split. Genes
and Development. 1992;6(12 B):2620-2634. doi:10.1101/gad.6.12b.2620
apa: Sasai, Y., Kageyama, R., Tagawa, Y., Shigemoto, R., & Nakanishi, S. (1992).
Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split. Genes and Development. Cold Spring Harbor Laboratory
Press. https://doi.org/10.1101/gad.6.12b.2620
chicago: Sasai, Yoshiki, Ryoichiro Kageyama, Yoshiaki Tagawa, Ryuichi Shigemoto,
and Shigetada Nakanishi. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development.
Cold Spring Harbor Laboratory Press, 1992. https://doi.org/10.1101/gad.6.12b.2620.
ieee: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, and S. Nakanishi, “Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split,” Genes and Development, vol. 6, no. 12 B. Cold Spring Harbor
Laboratory Press, pp. 2620–2634, 1992.
ista: Sasai Y, Kageyama R, Tagawa Y, Shigemoto R, Nakanishi S. 1992. Two mammalian
helix-loop-helix factors structurally related to Drosophila hairy and Enhancer
of split. Genes and Development. 6(12 B), 2620–2634.
mla: Sasai, Yoshiki, et al. “Two Mammalian Helix-Loop-Helix Factors Structurally
Related to Drosophila Hairy and Enhancer of Split.” Genes and Development,
vol. 6, no. 12 B, Cold Spring Harbor Laboratory Press, 1992, pp. 2620–34, doi:10.1101/gad.6.12b.2620.
short: Y. Sasai, R. Kageyama, Y. Tagawa, R. Shigemoto, S. Nakanishi, Genes and Development
6 (1992) 2620–2634.
date_created: 2018-12-11T11:58:15Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-17T14:52:29Z
day: '01'
doi: 10.1101/gad.6.12b.2620
extern: '1'
external_id:
pmid:
- '1340473'
intvolume: ' 6'
issue: 12 B
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://genesdev.cshlp.org/content/6/12b/2620
month: '01'
oa: 1
oa_version: Published Version
page: 2620 - 2634
pmid: 1
publication: Genes and Development
publication_identifier:
issn:
- 0890-9369
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
publist_id: '4364'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Two mammalian helix-loop-helix factors structurally related to Drosophila hairy
and Enhancer of split
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 6
year: '1992'
...
---
_id: '3469'
abstract:
- lang: eng
text: Glutamate-operated ion channels (GluR channels) of the L-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA)-kainate subtype are found in both neurons and glial cells of the central
nervous system. These channels are assembled from the GluR-A, -B, -C, and -D subunits;
channels containing a GluR-B subunit show an outwardly rectifying current-voltage
relation and low calcium permeability, whereas channels lacking the GluR-B subunit
are characterized by a doubly rectifying current-voltage relation and high calcium
permeability. Most cell types in the central nervous system coexpress several
subunits, including GluR-B. However, Bergmann glia in rat cerebellum do not express
GluR-B subunit genes. In a subset of cultured cerebellar glial cells, likely derived
from Bergmann glial cells. GluR channels exhibit doubly rectifying current-voltage
relations and high calcium permeability, whereas GluR channels of cerebellar neurons
have low calcium permeability. Thus, differential expression of the GluR-B subunit
gene in neurons and glia is one mechanism by which functional properties of native
GluR channels are regulated.
article_processing_charge: No
article_type: original
author:
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Alla
full_name: Khodorova, Alla
last_name: Khodorova
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: P.
full_name: Helm, P.
last_name: Helm
- first_name: William
full_name: Wisden, William
last_name: Wisden
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter
full_name: Seeburg, Peter
last_name: Seeburg
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Burnashev N, Khodorova A, Jonas PM, et al. Calcium-permeable AMPA-kainate receptors
in fusiform cerebellar glial cells. Science. 1992;256(5063):1566-1570.
doi:10.1126/science.1317970
apa: Burnashev, N., Khodorova, A., Jonas, P. M., Helm, P., Wisden, W., Monyer, H.,
… Sakmann, B. (1992). Calcium-permeable AMPA-kainate receptors in fusiform cerebellar
glial cells. Science. American Association for the Advancement of Science.
https://doi.org/10.1126/science.1317970
chicago: Burnashev, Nail, Alla Khodorova, Peter M Jonas, P. Helm, William Wisden,
Hannah Monyer, Peter Seeburg, and Bert Sakmann. “Calcium-Permeable AMPA-Kainate
Receptors in Fusiform Cerebellar Glial Cells.” Science. American Association
for the Advancement of Science, 1992. https://doi.org/10.1126/science.1317970.
ieee: N. Burnashev et al., “Calcium-permeable AMPA-kainate receptors in fusiform
cerebellar glial cells.,” Science, vol. 256, no. 5063. American Association
for the Advancement of Science, pp. 1566–1570, 1992.
ista: Burnashev N, Khodorova A, Jonas PM, Helm P, Wisden W, Monyer H, Seeburg P,
Sakmann B. 1992. Calcium-permeable AMPA-kainate receptors in fusiform cerebellar
glial cells. Science. 256(5063), 1566–1570.
mla: Burnashev, Nail, et al. “Calcium-Permeable AMPA-Kainate Receptors in Fusiform
Cerebellar Glial Cells.” Science, vol. 256, no. 5063, American Association
for the Advancement of Science, 1992, pp. 1566–70, doi:10.1126/science.1317970.
short: N. Burnashev, A. Khodorova, P.M. Jonas, P. Helm, W. Wisden, H. Monyer, P.
Seeburg, B. Sakmann, Science 256 (1992) 1566–1570.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-06-12T00:00:00Z
date_updated: 2022-03-16T13:24:52Z
day: '12'
doi: 10.1126/science.1317970
extern: '1'
external_id:
pmid:
- '1317970'
intvolume: ' 256'
issue: '5063'
language:
- iso: eng
main_file_link:
- url: https://www.science.org/doi/10.1126/science.1317970
month: '06'
oa_version: None
page: 1566 - 1570
pmid: 1
publication: Science
publication_identifier:
issn:
- 0036-8075
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '2918'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Calcium-permeable AMPA-kainate receptors in fusiform cerebellar glial cells.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 256
year: '1992'
...
---
_id: '3470'
abstract:
- lang: eng
text: Currents activated by glutamate receptor (GluR) agonists were recorded from
outside-out patches isolated from the soma of visually identified pyramidal neurones
of the (CA3 and CA1 region of rat hippocampal slices. α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid (AMPA). L-glutamate (L-Glu), and kainate (KA) were delivered either by bath
application through perfusion of the recording chamber or by rapid application
via a piezo-driven two-barrelled fast application system. 2. Bath application
of each of the three agonists activated inward currents in all patches (n = 134)
at holding potentials of -50 or -60 mV. The current amplitude increased in size
between 3 to 30 μM-AMPA and 100 μM to 1 mM-KA. With this slow mode of bath application,
the responses showed no apparent desensitization even at saturating concentrations
of AMPA (30 μM) and KA (1 mM). 3. The ratio of currents activated by 30 μM-AMPA
and 300 μM-KA showed a characteristic difference between CA3 and CA1 neurones.
The ratio was 0.242 ± 0.028 (mean ± S.E.M., n = 16) for CA3 cell patches and 0.097
± 0.012 (n = 8) for CA1 cell patches indicating that GluRs in the two cell populations
are different. 4. The steady-state current-voltage relations (I-Vs) for AMPA-
and KA-activated currents showed pronounced outward rectification for both cell
types (when the main cations are Na+ in the bath and Cs+ in the pipette solution).
The current reversed close to 0 mV and the ratio of chord conductances 80 mV on
either side of the reversal potential was 2.66 for KA-activated currents in CA3
cell patches and 2.60 in CA1 cell patches. AMPA-activated currents showed a time-dependent
increase after steps to positive membrane potentials and a decrease after steps
to negative voltages, indicating that a gating process is responsible for outward
rectification of the steady-state I-IV. 5. The permeability (P) of GluR channels
was high for Na+ as compared to Cs+ for both cell types (P(Na)/P(Cs) = 0.88 and
0.84). The permeability was low for N-methyl-D-glucamine+ (P(NMG)/P(Cs) ≤ 0.03)
and Ca2+ (P(Ca)/P(Cs) ≤0.05). 6. The current noise level increased during application
of AMPA or KA. Apparent single-channel conductances obtained from fluctuation
analysis were higher for AMPA than for KA, but similar for both cell types. In
CA3 cell patches, AMPA activated channels with an apparent chord conductance of
7.2 pS, KA of 3.0 pS conductance. 7. Fast agonist application revealed desensitization
of GluR channels which was dependent on the type of agonist, currents activated
by AMPA and L-Glu rose rapidly to a peak and then desensitized to a steady-state
current. In contrast, currents activated by fast application of KA rose to a plateau
and did not desensitize. The steady state current expressed as a percentage of
the peak current was higher for L-Glu than for AMPA and slightly higher for CA3
than for CA1 cell patches. For CA3 cell patches, this fraction amounted to 6.2
%, with 300 μM-L-Glu and 2.8%, with 300 μM-AMPA. For CA1 cell patches, corresponding
values were 3.6 and 1.9 % 8. The dose response relations for the peak current
activated by AMPA and L-Glu and the steady-state current activated by KA were
similar for CA3 and CA1 cell patches. The order of potency was AMPA > L-Glu
≃ KA for both cell types EC50 values 189, 342 and 344 μM for CA3 cell patches
and 183, 424 and 474 μM for CA1 cell patches). In all cases, the Hill coefficients
ranged between 12 and 1.7. 8. The rise of AMPA and L-Glu-activated currents became
faster with increasing agonist concentration for both cell types. With L-Glu,
rise times decreased from about 3 ms at 100 μM to 500 μs at 3 mM. The delay for
agonist concentrations ≥ 300 μM was described by the sum of two exponential functions.
The time constant of the predominant fast component was slightly concentration
dependent and decreased from about 12 ms at 300 μM to 8 ms at 3 mM-L-Glu. 10.
The current voltage relations of the peak currents activated by 300 μM-AMPA were
linear for both cell types with a reversal potential close to OmV. 11. It is concluded
that the GluR channels in pyramidal cells of hippocampal CA3 and CA1 regions are
distinet but share many pharmacological and functional properties. Comparison
of the properties of native and recombinant GluRs suggests that in both CA3 and
CA1 regions GluR channels are hetero-oligomers containing the GluR-B subunit.
acknowledgement: "We thank Dr D. Colquhoun, Dr J. P. Ruppersberg and Dr T. A. Verdoorn
for critically reading the manuscript, K. Bauer, C. Busch and F. Helmchen for computer
programming, and M. Kaiser for technical assistance. \r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Jonas PM, Sakmann B. Glutamate receptor channels in isolated patches from CA1
and CA3 pyramidal cells of rat hippocampal slices. Journal of Physiology.
1992;455:143-171. doi:10.1113/jphysiol.1992.sp019294
apa: Jonas, P. M., & Sakmann, B. (1992). Glutamate receptor channels in isolated
patches from CA1 and CA3 pyramidal cells of rat hippocampal slices. Journal
of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1992.sp019294
chicago: Jonas, Peter M, and Bert Sakmann. “Glutamate Receptor Channels in Isolated
Patches from CA1 and CA3 Pyramidal Cells of Rat Hippocampal Slices.” Journal
of Physiology. Wiley-Blackwell, 1992. https://doi.org/10.1113/jphysiol.1992.sp019294 .
ieee: P. M. Jonas and B. Sakmann, “Glutamate receptor channels in isolated patches
from CA1 and CA3 pyramidal cells of rat hippocampal slices,” Journal of Physiology,
vol. 455. Wiley-Blackwell, pp. 143–171, 1992.
ista: Jonas PM, Sakmann B. 1992. Glutamate receptor channels in isolated patches
from CA1 and CA3 pyramidal cells of rat hippocampal slices. Journal of Physiology.
455, 143–171.
mla: Jonas, Peter M., and Bert Sakmann. “Glutamate Receptor Channels in Isolated
Patches from CA1 and CA3 Pyramidal Cells of Rat Hippocampal Slices.” Journal
of Physiology, vol. 455, Wiley-Blackwell, 1992, pp. 143–71, doi:10.1113/jphysiol.1992.sp019294 .
short: P.M. Jonas, B. Sakmann, Journal of Physiology 455 (1992) 143–171.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-09-01T00:00:00Z
date_updated: 2022-03-16T13:01:55Z
day: '01'
doi: '10.1113/jphysiol.1992.sp019294 '
extern: '1'
external_id:
pmid:
- '1282929 '
intvolume: ' 455'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://physoc.onlinelibrary.wiley.com/doi/abs/10.1113/jphysiol.1992.sp019294
month: '09'
oa: 1
oa_version: Published Version
page: 143 - 171
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2917'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal
cells of rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 455
year: '1992'
...
---
_id: '3471'
abstract:
- lang: eng
text: 1. Outside-out patches were isolated from granule cells of dentate gyrus and
pyramidal cells of CA3 and CA1 regions of rat hippocampal slices. Patches were
exposed briefly to L-glutamate using a piezo-driven double-barrelled application
pipette. 2. Applications of glutamate (1 mM) of 1 ms duration activated patch
currents which rose and decayed rapidly. The 20-80% rise time of these glutamate
receptor (GluR)-mediated currents was usually 0.2-0.6 ms. At -50 mV the peak current
varied from 10 to 500 pA in different patches. 3. The peak current-voltage relation
for brief pulses of 1 mM glutamate was virtually linear in normal extracellular
solution for patches from the three cell types (-100 to 60 mV). 4. The permeability
of GluR channels activated at the peak to Ca2+, relative to K+, was less than
0.1 for all three cell types (under bi-ionic conditions with Ca2+ on the extracellular
side and K+ on the intracellular side of the membrane). 5. The offset decay time
constant of the current following 1 ms pulses of 1 mM glutamate was brief, with
mean values of 3.0 +/- 0.8, 2.5 +/- 0.7, and 2.3 +/- 0.7 ms for dentate, CA3 and
CA1 cell patches, respectively. Offset time constants were independent of membrane
potential and independent of glutamate concentration (200 microM and 1 mM) for
the three cell types. 6. Applications of 1 mM glutamate of 100 ms duration showed
that glutamate responses desensitized rapidly. The time constants for desensitization
were 9.4 +/- 2.7, 11.3 +/- 2.8, and 9.3 +/- 2.8 ms for patches from dentate, CA3
and CA1 cells respectively. Desensitization time constants were only weakly dependent
on glutamate concentration (200 microM and 1 mM) for the three cell types. Thus
offset time constants are about four times faster than desensitization time constants
for both glutamate concentrations. 7. Double pulse application of glutamate indicated
that even a 1 ms pulse of 1 mM glutamate causes partial (about 60%) desensitization
of GluR channels. The time course of recovery from desensitization was slower
in dentate gyrus granule cell patches than in CA3 or CA1 pyramidal cell patches.
8. Desensitization was studied at equilibrium by exposing patches to low glutamate
concentrations for at least 15 s before a 1 ms test pulse of 1 mM glutamate.
acknowledgement: 'We thank Drs N.Burnashev, P. Ruppersberg , and G.Stuart for critically
reading the manuscript, and Marlies Kaiser for technical assistance. D.C.is a recipient
of a Humboldt prize. '
article_processing_charge: No
article_type: original
author:
- first_name: D.
full_name: Colquhoun, D.
last_name: Colquhoun
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Bert
full_name: Sakmann, Bert
last_name: Sakmann
citation:
ama: Colquhoun D, Jonas PM, Sakmann B. Action of brief pulses of glutamate on AMPA/kainate
receptors in patches from different neurones of rat hippocampal slices. Journal
of Physiology. 1992;458:261-287. doi:10.1113/jphysiol.1992.sp019417
apa: Colquhoun, D., Jonas, P. M., & Sakmann, B. (1992). Action of brief pulses
of glutamate on AMPA/kainate receptors in patches from different neurones of rat
hippocampal slices. Journal of Physiology. Wiley-Blackwell. https://doi.org/10.1113/jphysiol.1992.sp019417
chicago: Colquhoun, D., Peter M Jonas, and Bert Sakmann. “Action of Brief Pulses
of Glutamate on AMPA/Kainate Receptors in Patches from Different Neurones of Rat
Hippocampal Slices.” Journal of Physiology. Wiley-Blackwell, 1992. https://doi.org/10.1113/jphysiol.1992.sp019417.
ieee: D. Colquhoun, P. M. Jonas, and B. Sakmann, “Action of brief pulses of glutamate
on AMPA/kainate receptors in patches from different neurones of rat hippocampal
slices,” Journal of Physiology, vol. 458. Wiley-Blackwell, pp. 261–287,
1992.
ista: Colquhoun D, Jonas PM, Sakmann B. 1992. Action of brief pulses of glutamate
on AMPA/kainate receptors in patches from different neurones of rat hippocampal
slices. Journal of Physiology. 458, 261–287.
mla: Colquhoun, D., et al. “Action of Brief Pulses of Glutamate on AMPA/Kainate
Receptors in Patches from Different Neurones of Rat Hippocampal Slices.” Journal
of Physiology, vol. 458, Wiley-Blackwell, 1992, pp. 261–87, doi:10.1113/jphysiol.1992.sp019417.
short: D. Colquhoun, P.M. Jonas, B. Sakmann, Journal of Physiology 458 (1992) 261–287.
date_created: 2018-12-11T12:03:30Z
date_published: 1992-12-01T00:00:00Z
date_updated: 2022-03-16T12:41:01Z
day: '01'
doi: 10.1113/jphysiol.1992.sp019417
extern: '1'
external_id:
pmid:
- '1338788'
intvolume: ' 458'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1175155/
month: '12'
oa: 1
oa_version: Published Version
page: 261 - 287
pmid: 1
publication: Journal of Physiology
publication_identifier:
issn:
- 0022-3751
publication_status: published
publisher: Wiley-Blackwell
publist_id: '2916'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Action of brief pulses of glutamate on AMPA/kainate receptors in patches from
different neurones of rat hippocampal slices
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 458
year: '1992'
...
---
_id: '4049'
abstract:
- lang: eng
text: The edge-insertion paradigm improves a triangulation of a finite point set
in R2 iteratively by adding a new edge, deleting intersecting old edges, and retriangulating
the resulting two polygonal regions. After presenting an abstract view of the
paradigm, this paper shows that it can be used to obtain polynomial time algorithms
for several types of optimal triangulations.
acknowledgement: Research of the second author is supported by the National Science
Foundation under grant no. CCR-8921421 and under the Alan T. Waterman award, grant
no. CCR-9118874. Any opinions, finding and conclusions or recommendations expressed
in this publication are those of the authors and do not necessarily reflect the
view of the National Science Foundation. Part of the work was done while the second,
third, and fourth authors visited the Xerox Palo Alto Research Center. The fifth
author is on study leave from the National University of Singapore, Republic of
Singapore.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Marshall
full_name: Bern, Marshall
last_name: Bern
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: David
full_name: Eppstein, David
last_name: Eppstein
- first_name: Stephen
full_name: Mitchell, Stephen
last_name: Mitchell
- first_name: Tiow
full_name: Tan, Tiow
last_name: Tan
citation:
ama: 'Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. Edge insertion for
optimal triangulations. In: Simon I, ed. 1st Latin American Symposium on Theoretical
Informatics. Vol 583. Springer; 1992:46-60. doi:10.1007/BFb0023816'
apa: 'Bern, M., Edelsbrunner, H., Eppstein, D., Mitchell, S., & Tan, T. (1992).
Edge insertion for optimal triangulations. In I. Simon (Ed.), 1st Latin American
Symposium on Theoretical Informatics (Vol. 583, pp. 46–60). São Paulo, Brazil:
Springer. https://doi.org/10.1007/BFb0023816'
chicago: Bern, Marshall, Herbert Edelsbrunner, David Eppstein, Stephen Mitchell,
and Tiow Tan. “Edge Insertion for Optimal Triangulations.” In 1st Latin American
Symposium on Theoretical Informatics, edited by Imre Simon, 583:46–60. Springer,
1992. https://doi.org/10.1007/BFb0023816.
ieee: M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, and T. Tan, “Edge insertion
for optimal triangulations,” in 1st Latin American Symposium on Theoretical
Informatics, São Paulo, Brazil, 1992, vol. 583, pp. 46–60.
ista: 'Bern M, Edelsbrunner H, Eppstein D, Mitchell S, Tan T. 1992. Edge insertion
for optimal triangulations. 1st Latin American Symposium on Theoretical Informatics.
LATIN: Latin American Symposium on Theoretical Informatics , LNCS, vol. 583, 46–60.'
mla: Bern, Marshall, et al. “Edge Insertion for Optimal Triangulations.” 1st
Latin American Symposium on Theoretical Informatics, edited by Imre Simon,
vol. 583, Springer, 1992, pp. 46–60, doi:10.1007/BFb0023816.
short: M. Bern, H. Edelsbrunner, D. Eppstein, S. Mitchell, T. Tan, in:, I. Simon
(Ed.), 1st Latin American Symposium on Theoretical Informatics, Springer, 1992,
pp. 46–60.
conference:
end_date: 1992-04-10
location: São Paulo, Brazil
name: 'LATIN: Latin American Symposium on Theoretical Informatics '
start_date: 1992-04-06
date_created: 2018-12-11T12:06:38Z
date_published: 1992-04-07T00:00:00Z
date_updated: 2022-03-16T08:04:53Z
day: '07'
doi: 10.1007/BFb0023816
editor:
- first_name: Imre
full_name: Simon, Imre
last_name: Simon
extern: '1'
intvolume: ' 583'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0023816
month: '04'
oa_version: None
page: 46 - 60
publication: 1st Latin American Symposium on Theoretical Informatics
publication_identifier:
isbn:
- 978-3-540-55284-0
publication_status: published
publisher: Springer
publist_id: '2076'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Edge insertion for optimal triangulations
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 583
year: '1992'
...
---
_id: '4053'
abstract:
- lang: eng
text: We show that the maximum number of edges bounding m faces in an arrangement
of n line segments in the plane is O(m2/3n2/3+nα(n)+nlog m). This improves a previous
upper bound of Edelsbrunner et al. [5] and almost matches the best known lower
bound which is Ω(m2/3n2/3+nα(n)). In addition, we show that the number of edges
bounding any m faces in an arrangement of n line segments with a total of t intersecting
pairs is O(m2/3t1/3+nα(t/n)+nmin{log m,log t/n}), almost matching the lower bound
of Ω(m2/3t1/3+nα(t/n)) demonstrated in this paper.
article_processing_charge: No
article_type: original
author:
- first_name: Boris
full_name: Aronov, Boris
last_name: Aronov
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: Aronov B, Edelsbrunner H, Guibas L, Sharir M. The number of edges of many faces
in a line segment arrangement. Combinatorica. 1992;12(3):261-274. doi:10.1007/BF01285815
apa: Aronov, B., Edelsbrunner, H., Guibas, L., & Sharir, M. (1992). The number
of edges of many faces in a line segment arrangement. Combinatorica. Springer.
https://doi.org/10.1007/BF01285815
chicago: Aronov, Boris, Herbert Edelsbrunner, Leonidas Guibas, and Micha Sharir.
“The Number of Edges of Many Faces in a Line Segment Arrangement.” Combinatorica.
Springer, 1992. https://doi.org/10.1007/BF01285815.
ieee: B. Aronov, H. Edelsbrunner, L. Guibas, and M. Sharir, “The number of edges
of many faces in a line segment arrangement,” Combinatorica, vol. 12, no.
3. Springer, pp. 261–274, 1992.
ista: Aronov B, Edelsbrunner H, Guibas L, Sharir M. 1992. The number of edges of
many faces in a line segment arrangement. Combinatorica. 12(3), 261–274.
mla: Aronov, Boris, et al. “The Number of Edges of Many Faces in a Line Segment
Arrangement.” Combinatorica, vol. 12, no. 3, Springer, 1992, pp. 261–74,
doi:10.1007/BF01285815.
short: B. Aronov, H. Edelsbrunner, L. Guibas, M. Sharir, Combinatorica 12 (1992)
261–274.
date_created: 2018-12-11T12:06:40Z
date_published: 1992-09-01T00:00:00Z
date_updated: 2022-03-15T15:44:26Z
day: '01'
doi: 10.1007/BF01285815
extern: '1'
intvolume: ' 12'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/article/10.1007/BF01285815
month: '09'
oa_version: None
page: 261 - 274
publication: Combinatorica
publication_identifier:
issn:
- 0209-9683
publication_status: published
publisher: Springer
publist_id: '2074'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The number of edges of many faces in a line segment arrangement
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 12
year: '1992'
...
---
_id: '4504'
abstract:
- lang: eng
text: "Real-time systems operate in “real,” continuous time and state changes may
occur at any real-numbered time point. Yet many verification methods are based
on the assumption that states are observed at integer time points only. What can
we conclude if a real-time system has been shown “correct” for integral observations?\r\n\r\nInteger
time verification techniques suffice if the problem of whether all real-numbered
behaviors of a system satisfy a property can be reduced to the question of whether
the integral observations satisfy a (possibly modified) property. We show that
this reduction is possible for a large and important class of systems and properties:
the class of systems includes all systems that can be modeled as timed transition
systems; the class of properties includes time-bounded invariance and time-bounded
response."
acknowledgement: "A full version of this paper (including all proofs) is available
as a technical report from Cornell University and Stanford University. The research
was supported in part by the National Science Foundation under grants CCR-89-11512
and CCR-89-13641, by the Defense Advanced Research Projects Agency under contract
NAG2-703, by the United States Air Force Office of Scientific Research under contract
AFOSR-90-0057, and by the European Community ESPRIT Basic Research Action Project
3096 (SPEC).\r\n\r\nSponsors: National Science Foundation grant CCR-89-11512, National
Science Foundation grant CCR-89-13641, Defense Advanced Research Projects Agency
contract NAG2-703, United States Air Force Office of Scientific Research contract
AFOSR-90-0057, European Community ESPRIT Basic Research Action Project 3096 (SPEC).\r\n"
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Zohar
full_name: Manna, Zohar
last_name: Manna
- first_name: Amir
full_name: Pnueli, Amir
last_name: Pnueli
citation:
ama: 'Henzinger TA, Manna Z, Pnueli A. What good are digital clocks? In: 19th
International Colloquium on Automata, Languages and Programming. Vol 623.
Springer; 1992:545-558. doi:10.1007/3-540-55719-9_103'
apa: 'Henzinger, T. A., Manna, Z., & Pnueli, A. (1992). What good are digital
clocks? In 19th International Colloquium on Automata, Languages and Programming
(Vol. 623, pp. 545–558). Vienna, Austria: Springer. https://doi.org/10.1007/3-540-55719-9_103'
chicago: Henzinger, Thomas A, Zohar Manna, and Amir Pnueli. “What Good Are Digital
Clocks?” In 19th International Colloquium on Automata, Languages and Programming,
623:545–58. Springer, 1992. https://doi.org/10.1007/3-540-55719-9_103.
ieee: T. A. Henzinger, Z. Manna, and A. Pnueli, “What good are digital clocks?,”
in 19th International Colloquium on Automata, Languages and Programming,
Vienna, Austria, 1992, vol. 623, pp. 545–558.
ista: 'Henzinger TA, Manna Z, Pnueli A. 1992. What good are digital clocks? 19th
International Colloquium on Automata, Languages and Programming. ICALP: Automata,
Languages and Programming, LNCS, vol. 623, 545–558.'
mla: Henzinger, Thomas A., et al. “What Good Are Digital Clocks?” 19th International
Colloquium on Automata, Languages and Programming, vol. 623, Springer, 1992,
pp. 545–58, doi:10.1007/3-540-55719-9_103.
short: T.A. Henzinger, Z. Manna, A. Pnueli, in:, 19th International Colloquium on
Automata, Languages and Programming, Springer, 1992, pp. 545–558.
conference:
end_date: 1992-07-17
location: Vienna, Austria
name: 'ICALP: Automata, Languages and Programming'
start_date: 1992-07-13
date_created: 2018-12-11T12:09:11Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-14T09:47:09Z
day: '01'
doi: 10.1007/3-540-55719-9_103
extern: '1'
intvolume: ' 623'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-55719-9_103
month: '01'
oa_version: None
page: 545 - 558
publication: 19th International Colloquium on Automata, Languages and Programming
publication_status: published
publisher: Springer
publist_id: '223'
quality_controlled: '1'
status: public
title: What good are digital clocks?
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 623
year: '1992'
...
---
_id: '2482'
abstract:
- lang: eng
text: The complementary DNA of a metabotropic glutamate receptor coupled to inositol
phosphate/Ca2+ signal transduction has been cloned and characterized. This receptor
shows no sequence similarity to conventional G protein-coupled receptors and has
a unique structure with large hydrophilic sequences at both sides of seven putative
membrane-spanning domains. Abundant expression of this messenger RNA is observed
in neuronal cells in hippocampal dentate gyrus and CA2-3 and in cerebellar Purkinje
cells, suggesting the importance of this receptor in specific hippocampal and
cerebellar functions.
article_processing_charge: No
article_type: original
author:
- first_name: Masayuki
full_name: Masu, Masayuki
last_name: Masu
- first_name: Yasuto
full_name: Tanabe, Yasuto
last_name: Tanabe
- first_name: Kunihiro
full_name: Tsuchida, Kunihiro
last_name: Tsuchida
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. Sequence and expression
of a metabotropic glutamate receptor. Nature. 1991;349(6312):760-765. doi:10.1038/349760a0
apa: Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R., & Nakanishi, S. (1991).
Sequence and expression of a metabotropic glutamate receptor. Nature. Nature
Publishing Group. https://doi.org/10.1038/349760a0
chicago: Masu, Masayuki, Yasuto Tanabe, Kunihiro Tsuchida, Ryuichi Shigemoto, and
Shigetada Nakanishi. “Sequence and Expression of a Metabotropic Glutamate Receptor.”
Nature. Nature Publishing Group, 1991. https://doi.org/10.1038/349760a0.
ieee: M. Masu, Y. Tanabe, K. Tsuchida, R. Shigemoto, and S. Nakanishi, “Sequence
and expression of a metabotropic glutamate receptor,” Nature, vol. 349,
no. 6312. Nature Publishing Group, pp. 760–765, 1991.
ista: Masu M, Tanabe Y, Tsuchida K, Shigemoto R, Nakanishi S. 1991. Sequence and
expression of a metabotropic glutamate receptor. Nature. 349(6312), 760–765.
mla: Masu, Masayuki, et al. “Sequence and Expression of a Metabotropic Glutamate
Receptor.” Nature, vol. 349, no. 6312, Nature Publishing Group, 1991, pp.
760–65, doi:10.1038/349760a0.
short: M. Masu, Y. Tanabe, K. Tsuchida, R. Shigemoto, S. Nakanishi, Nature 349 (1991)
760–765.
date_created: 2018-12-11T11:57:55Z
date_published: 1991-02-28T00:00:00Z
date_updated: 2022-03-03T15:37:36Z
day: '28'
doi: 10.1038/349760a0
extern: '1'
external_id:
pmid:
- '1847995 '
intvolume: ' 349'
issue: '6312'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/349760a0
month: '02'
oa_version: None
page: 760 - 765
pmid: 1
publication: Nature
publication_identifier:
eissn:
- 1476-4687
issn:
- 0028-0836
publication_status: published
publisher: Nature Publishing Group
publist_id: '4419'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sequence and expression of a metabotropic glutamate receptor
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 349
year: '1991'
...
---
_id: '3566'
abstract:
- lang: eng
text: This paper proves an O(m2/3n2/3 + m + n) upper bound on the number of incidences
between m points and n hyperplanes in four dimensions, assuming all points lie
on one side of each hyperplane and the points and hyperplanes satisfy certain
natural general position conditions. This result has application to various three-dimensional
combinatorial distance problems. For example, it implies the same upper bound
for the number of bichromatic minimum distance pairs in a set of m blue and n
red points in three-dimensional space. This improves the best previous bound for
this problem. © Springer-Verlag Berlin Heidelberg 1990.
alternative_title:
- DIMACS Series in Discrete Mathematics and Theoretical Computer Science
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: 'Edelsbrunner H, Sharir M. A hyperplane incidence problem with applications
to counting distances. In: Applied Geometry and Discrete Mathematics: The Victor
Klee Festschrift. Vol 4. American Mathematical Society; 1991:253-263.'
apa: 'Edelsbrunner, H., & Sharir, M. (1991). A hyperplane incidence problem
with applications to counting distances. In Applied Geometry and Discrete Mathematics:
The Victor Klee Festschrift (Vol. 4, pp. 253–263). American Mathematical Society.'
chicago: 'Edelsbrunner, Herbert, and Micha Sharir. “A Hyperplane Incidence Problem
with Applications to Counting Distances.” In Applied Geometry and Discrete
Mathematics: The Victor Klee Festschrift, 4:253–63. American Mathematical
Society, 1991.'
ieee: 'H. Edelsbrunner and M. Sharir, “A hyperplane incidence problem with applications
to counting distances,” in Applied Geometry and Discrete Mathematics: The Victor
Klee Festschrift, vol. 4, American Mathematical Society, 1991, pp. 253–263.'
ista: 'Edelsbrunner H, Sharir M. 1991.A hyperplane incidence problem with applications
to counting distances. In: Applied Geometry and Discrete Mathematics: The Victor
Klee Festschrift. DIMACS Series in Discrete Mathematics and Theoretical Computer
Science, vol. 4, 253–263.'
mla: 'Edelsbrunner, Herbert, and Micha Sharir. “A Hyperplane Incidence Problem with
Applications to Counting Distances.” Applied Geometry and Discrete Mathematics:
The Victor Klee Festschrift, vol. 4, American Mathematical Society, 1991,
pp. 253–63.'
short: 'H. Edelsbrunner, M. Sharir, in:, Applied Geometry and Discrete Mathematics:
The Victor Klee Festschrift, American Mathematical Society, 1991, pp. 253–263.'
date_created: 2018-12-11T12:04:00Z
date_published: 1991-04-01T00:00:00Z
date_updated: 2022-03-03T13:27:01Z
day: '01'
extern: '1'
intvolume: ' 4'
language:
- iso: eng
main_file_link:
- url: http://www.cs.duke.edu/~edels/Papers/1991-B-01-HyperplaneIncidence.pdf
month: '04'
oa_version: None
page: 253 - 263
publication: 'Applied Geometry and Discrete Mathematics: The Victor Klee Festschrift'
publication_identifier:
isbn:
- 978-0897913850
publication_status: published
publisher: American Mathematical Society
publist_id: '2819'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A hyperplane incidence problem with applications to counting distances
type: book_chapter
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 4
year: '1991'
...
---
_id: '4054'
abstract:
- lang: eng
text: The zone theorem for an arrangement of n hyperplanes in d-dimensional real
space says that the total number of faces bounding the cells intersected by another
hyperplane is O(n d–1). This result is the basis of a time-optimal incremental
algorithm that constructs a hyperplane arrangement and has a host of other algorithmic
and combinatorial applications. Unfortunately, the original proof of the zone
theorem, for d ge 3, turned out to contain a serious and irreparable error. This
paper presents a new proof of the theorem. Our proof is based on an inductive
argument, which also applies in the case of pseudo-hyperplane arrangements. We
also briefly discuss the fallacies of the old proof along with some ways of partially
saving that approach.
acknowledgement: Research of Herbert Edelsbrunner was supported by the National Science
Foundation under grant CCR-89-21421. Raimund Seidel acknowledges support by an NSF
Presidential Young Investigator Grant CCR-90-58440. Micha Sharir has been supported
by ONR Grant N00014-90-J-1284, by NSF Grant CCR-89-01484, and by grants from the
U.S.-Israeli Binational Science Foundation, the German-Israeli Foundation for Scientific
Research and Development, and the Fund for Basic Research of the Israeli Academy
of Sciences.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Raimund
full_name: Seidel, Raimund
last_name: Seidel
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
citation:
ama: 'Edelsbrunner H, Seidel R, Sharir M. On the zone theorem for hyperplane arrangements.
In: Vol 555. Springer; 1991:108-123. doi:10.1007/BFb0038185'
apa: Edelsbrunner, H., Seidel, R., & Sharir, M. (1991). On the zone theorem
for hyperplane arrangements (Vol. 555, pp. 108–123). Presented at the New Results
and New Trends in Computer Science , Springer. https://doi.org/10.1007/BFb0038185
chicago: Edelsbrunner, Herbert, Raimund Seidel, and Micha Sharir. “On the Zone Theorem
for Hyperplane Arrangements,” 555:108–23. Springer, 1991. https://doi.org/10.1007/BFb0038185.
ieee: H. Edelsbrunner, R. Seidel, and M. Sharir, “On the zone theorem for hyperplane
arrangements,” presented at the New Results and New Trends in Computer Science
, 1991, vol. 555, pp. 108–123.
ista: Edelsbrunner H, Seidel R, Sharir M. 1991. On the zone theorem for hyperplane
arrangements. New Results and New Trends in Computer Science , LNCS, vol. 555,
108–123.
mla: Edelsbrunner, Herbert, et al. On the Zone Theorem for Hyperplane Arrangements.
Vol. 555, Springer, 1991, pp. 108–23, doi:10.1007/BFb0038185.
short: H. Edelsbrunner, R. Seidel, M. Sharir, in:, Springer, 1991, pp. 108–123.
conference:
name: 'New Results and New Trends in Computer Science '
date_created: 2018-12-11T12:06:40Z
date_published: 1991-11-13T00:00:00Z
date_updated: 2022-02-28T15:13:37Z
day: '13'
doi: 10.1007/BFb0038185
extern: '1'
intvolume: ' 555'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/BFb0038185
month: '11'
oa_version: None
page: 108 - 123
publication_status: published
publisher: Springer
publist_id: '2068'
quality_controlled: '1'
status: public
title: On the zone theorem for hyperplane arrangements
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 555
year: '1991'
...
---
_id: '4056'
abstract:
- lang: eng
text: This paper proves that for every n ≥ 4 there is a convex n-gon such that the
vertices of 2n - 7 vertex pairs are one unit of distance apart. This improves
the previously best lower bound of ⌊ (5n - 5) 3⌋ given by Erdo{combining double
acute accent}s and Moser if n ≥ 17.
acknowledgement: The first author is pleased to acknowledge partial support by the
Amoco Fnd. Fat. Dev. Comput. Sci. i-6-44862 and the National Science Foundation
under Grant CCR-8714565.
article_processing_charge: No
article_type: original
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Péter
full_name: Hajnal, Péter
last_name: Hajnal
citation:
ama: Edelsbrunner H, Hajnal P. A lower bound on the number of unit distances between
the vertices of a convex polygon. Journal of Combinatorial Theory Series A.
1991;56(2):312-316. doi:10.1016/0097-3165(91)90042-F
apa: Edelsbrunner, H., & Hajnal, P. (1991). A lower bound on the number of unit
distances between the vertices of a convex polygon. Journal of Combinatorial
Theory Series A. Elsevier. https://doi.org/10.1016/0097-3165(91)90042-F
chicago: Edelsbrunner, Herbert, and Péter Hajnal. “A Lower Bound on the Number of
Unit Distances between the Vertices of a Convex Polygon.” Journal of Combinatorial
Theory Series A. Elsevier, 1991. https://doi.org/10.1016/0097-3165(91)90042-F.
ieee: H. Edelsbrunner and P. Hajnal, “A lower bound on the number of unit distances
between the vertices of a convex polygon,” Journal of Combinatorial Theory
Series A, vol. 56, no. 2. Elsevier, pp. 312–316, 1991.
ista: Edelsbrunner H, Hajnal P. 1991. A lower bound on the number of unit distances
between the vertices of a convex polygon. Journal of Combinatorial Theory Series
A. 56(2), 312–316.
mla: Edelsbrunner, Herbert, and Péter Hajnal. “A Lower Bound on the Number of Unit
Distances between the Vertices of a Convex Polygon.” Journal of Combinatorial
Theory Series A, vol. 56, no. 2, Elsevier, 1991, pp. 312–16, doi:10.1016/0097-3165(91)90042-F.
short: H. Edelsbrunner, P. Hajnal, Journal of Combinatorial Theory Series A 56 (1991)
312–316.
date_created: 2018-12-11T12:06:41Z
date_published: 1991-03-01T00:00:00Z
date_updated: 2022-03-02T09:56:10Z
day: '01'
doi: 10.1016/0097-3165(91)90042-F
extern: '1'
intvolume: ' 56'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.sciencedirect.com/science/article/pii/009731659190042F?via%3Dihub
month: '03'
oa: 1
oa_version: Published Version
page: 312 - 316
publication: Journal of Combinatorial Theory Series A
publication_identifier:
eissn:
- 1096-0899
issn:
- 0097-3165
publication_status: published
publisher: Elsevier
publist_id: '2070'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A lower bound on the number of unit distances between the vertices of a convex
polygon
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 56
year: '1991'
...
---
_id: '4059'
abstract:
- lang: eng
text: Let P be a simple polygon with n vertices. We present a simple decomposition
scheme that partitions the interior of P into O(n) so-called geodesic triangles,
so that any line segment interior to P crosses at most 2 log n of these triangles.
This decomposition can be used to preprocess P in time O(n log n) and storage
O(n), so that any ray-shooting query can be answered in time O(log n).The algorithms
are fairly simple and easy to implement. We also extend this technique to the
case of ray-shooting amidst k polygonal obstacles with a total of n edges, so
that a query can be answered in O(radicklog n) time.
acknowledgement: Work by Bernard Chazelle has been supported by NSF Grant CCR-87-00917.
Work by Herbert Edelsbrunner has been supported by NSF Grant CCR-89-21421. Work
by Micha Sharir has been supported by ONR Grants N00014-89-J-3042 and N00014-90-J-1284,
by NSF Grant CCR-89-01484, and by grants from the U.S.-Israeli Binational Science
Foundation, the Fund for Basic Research administered by the Israeli Academy of Sciences,
and the G.I.F., the German-Israeli Foundation for Scientific Research and Development.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Bernard
full_name: Chazelle, Bernard
last_name: Chazelle
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Michelangelo
full_name: Grigni, Michelangelo
last_name: Grigni
- first_name: Leonidas
full_name: Guibas, Leonidas
last_name: Guibas
- first_name: John
full_name: Hershberger, John
last_name: Hershberger
- first_name: Micha
full_name: Sharir, Micha
last_name: Sharir
- first_name: Jack
full_name: Snoeyink, Jack
last_name: Snoeyink
citation:
ama: 'Chazelle B, Edelsbrunner H, Grigni M, et al. Ray shooting in polygons using
geodesic triangulations. In: 18th International Colloquium on Automata, Languages
and Programming. Vol 510. Springer; 1991:661-673. doi:10.1007/3-540-54233-7_172'
apa: 'Chazelle, B., Edelsbrunner, H., Grigni, M., Guibas, L., Hershberger, J., Sharir,
M., & Snoeyink, J. (1991). Ray shooting in polygons using geodesic triangulations.
In 18th International Colloquium on Automata, Languages and Programming
(Vol. 510, pp. 661–673). Madrid, Spain: Springer. https://doi.org/10.1007/3-540-54233-7_172'
chicago: Chazelle, Bernard, Herbert Edelsbrunner, Michelangelo Grigni, Leonidas
Guibas, John Hershberger, Micha Sharir, and Jack Snoeyink. “Ray Shooting in Polygons
Using Geodesic Triangulations.” In 18th International Colloquium on Automata,
Languages and Programming, 510:661–73. Springer, 1991. https://doi.org/10.1007/3-540-54233-7_172.
ieee: B. Chazelle et al., “Ray shooting in polygons using geodesic triangulations,”
in 18th International Colloquium on Automata, Languages and Programming,
Madrid, Spain, 1991, vol. 510, pp. 661–673.
ista: 'Chazelle B, Edelsbrunner H, Grigni M, Guibas L, Hershberger J, Sharir M,
Snoeyink J. 1991. Ray shooting in polygons using geodesic triangulations. 18th
International Colloquium on Automata, Languages and Programming. ICALP: Automata,
Languages and Programming, LNCS, vol. 510, 661–673.'
mla: Chazelle, Bernard, et al. “Ray Shooting in Polygons Using Geodesic Triangulations.”
18th International Colloquium on Automata, Languages and Programming, vol.
510, Springer, 1991, pp. 661–73, doi:10.1007/3-540-54233-7_172.
short: B. Chazelle, H. Edelsbrunner, M. Grigni, L. Guibas, J. Hershberger, M. Sharir,
J. Snoeyink, in:, 18th International Colloquium on Automata, Languages and Programming,
Springer, 1991, pp. 661–673.
conference:
end_date: 1991-07-12
location: Madrid, Spain
name: 'ICALP: Automata, Languages and Programming'
start_date: 1991-07-08
date_created: 2018-12-11T12:06:42Z
date_published: 1991-06-20T00:00:00Z
date_updated: 2022-02-28T14:53:03Z
day: '20'
doi: 10.1007/3-540-54233-7_172
extern: '1'
intvolume: ' 510'
language:
- iso: eng
main_file_link:
- url: https://link.springer.com/chapter/10.1007/3-540-54233-7_172
month: '06'
oa_version: None
page: 661 - 673
publication: 18th International Colloquium on Automata, Languages and Programming
publication_status: published
publisher: Springer
publist_id: '2066'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Ray shooting in polygons using geodesic triangulations
type: conference
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 510
year: '1991'
...