[{"pmid":1,"project":[{"_id":"260F1432-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","grant_number":"742573"},{"grant_number":"25239","name":"Mesendoderm specification in zebrafish: The role of extraembryonic tissues","_id":"26B1E39C-B435-11E9-9278-68D0E5697425"}],"department":[{"_id":"CaHe"}],"isi":1,"scopus_import":"1","has_accepted_license":"1","date_published":"2021-06-01T00:00:00Z","acknowledgement":"We thank Nicoletta Petridou, Diana Pinheiro, Cornelia Schwayer and Stefania Tavano for feedback on the manuscript. Research in the Heisenberg lab is supported by an ERC Advanced Grant (MECSPEC 742573) to C.-P.H. A.S. is a recipient of a DOC Fellowship of the Austrian Academy of Science.","volume":474,"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)"},"related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"12891"}]},"intvolume":"       474","status":"public","type":"journal_article","language":[{"iso":"eng"}],"page":"71-81","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","oa_version":"Published Version","abstract":[{"lang":"eng","text":"During development, a single cell is transformed into a highly complex organism through progressive cell division, specification and rearrangement. An important prerequisite for the emergence of patterns within the developing organism is to establish asymmetries at various scales, ranging from individual cells to the entire embryo, eventually giving rise to the different body structures. This becomes especially apparent during gastrulation, when the earliest major lineage restriction events lead to the formation of the different germ layers. Traditionally, the unfolding of the developmental program from symmetry breaking to germ layer formation has been studied by dissecting the contributions of different signaling pathways and cellular rearrangements in the in vivo context of intact embryos. Recent efforts, using the intrinsic capacity of embryonic stem cells to self-assemble and generate embryo-like structures de novo, have opened new avenues for understanding the many ways by which an embryo can be built and the influence of extrinsic factors therein. Here, we discuss and compare divergent and conserved strategies leading to germ layer formation in embryos as compared to in vitro systems, their upstream molecular cascades and the role of extrinsic factors in this process."}],"file_date_updated":"2021-08-11T10:28:06Z","quality_controlled":"1","article_type":"original","article_processing_charge":"Yes (via OA deal)","publication_identifier":{"issn":["0012-1606"]},"title":"Reassembling gastrulation","publication":"Developmental Biology","date_updated":"2026-05-29T22:30:14Z","publisher":"Elsevier","year":"2021","doi":"10.1016/j.ydbio.2020.12.014","author":[{"last_name":"Schauer","id":"30A536BA-F248-11E8-B48F-1D18A9856A87","full_name":"Schauer, Alexandra","first_name":"Alexandra","orcid":"0000-0001-7659-9142"},{"full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"}],"month":"06","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"isi":["000639461800008"],"pmid":["33352181"]},"citation":{"apa":"Schauer, A., &#38; Heisenberg, C.-P. J. (2021). Reassembling gastrulation. <i>Developmental Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ydbio.2020.12.014\">https://doi.org/10.1016/j.ydbio.2020.12.014</a>","short":"A. Schauer, C.-P.J. Heisenberg, Developmental Biology 474 (2021) 71–81.","ieee":"A. Schauer and C.-P. J. Heisenberg, “Reassembling gastrulation,” <i>Developmental Biology</i>, vol. 474. Elsevier, pp. 71–81, 2021.","mla":"Schauer, Alexandra, and Carl-Philipp J. Heisenberg. “Reassembling Gastrulation.” <i>Developmental Biology</i>, vol. 474, Elsevier, 2021, pp. 71–81, doi:<a href=\"https://doi.org/10.1016/j.ydbio.2020.12.014\">10.1016/j.ydbio.2020.12.014</a>.","chicago":"Schauer, Alexandra, and Carl-Philipp J Heisenberg. “Reassembling Gastrulation.” <i>Developmental Biology</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.ydbio.2020.12.014\">https://doi.org/10.1016/j.ydbio.2020.12.014</a>.","ama":"Schauer A, Heisenberg C-PJ. Reassembling gastrulation. <i>Developmental Biology</i>. 2021;474:71-81. doi:<a href=\"https://doi.org/10.1016/j.ydbio.2020.12.014\">10.1016/j.ydbio.2020.12.014</a>","ista":"Schauer A, Heisenberg C-PJ. 2021. Reassembling gastrulation. Developmental Biology. 474, 71–81."},"file":[{"date_updated":"2021-08-11T10:28:06Z","file_name":"2021_DevBiology_Schauer.pdf","file_id":"9880","success":1,"checksum":"fa2a5731fd16ab171b029f32f031c440","creator":"kschuh","content_type":"application/pdf","file_size":1440321,"relation":"main_file","access_level":"open_access","date_created":"2021-08-11T10:28:06Z"}],"publication_status":"published","keyword":["Developmental Biology","Cell Biology","Molecular Biology"],"ddc":["570"],"date_created":"2020-12-22T09:53:34Z","oa":1,"ec_funded":1,"_id":"8966","day":"01"},{"citation":{"short":"J.A. Cohn, E.R. Cebul, G. Valperga, L. Brose, M. de Bono, M.G. Heiman, J.T. Pierce, Developmental Biology 461 (2020) 66–74.","apa":"Cohn, J. A., Cebul, E. R., Valperga, G., Brose, L., de Bono, M., Heiman, M. G., &#38; Pierce, J. T. (2020). Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron. <i>Developmental Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ydbio.2020.01.005\">https://doi.org/10.1016/j.ydbio.2020.01.005</a>","mla":"Cohn, Jesse A., et al. “Long-Term Activity Drives Dendritic Branch Elaboration of a C. Elegans Sensory Neuron.” <i>Developmental Biology</i>, vol. 461, no. 1, Elsevier, 2020, pp. 66–74, doi:<a href=\"https://doi.org/10.1016/j.ydbio.2020.01.005\">10.1016/j.ydbio.2020.01.005</a>.","ieee":"J. A. Cohn <i>et al.</i>, “Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron,” <i>Developmental Biology</i>, vol. 461, no. 1. Elsevier, pp. 66–74, 2020.","ama":"Cohn JA, Cebul ER, Valperga G, et al. Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron. <i>Developmental Biology</i>. 2020;461(1):66-74. doi:<a href=\"https://doi.org/10.1016/j.ydbio.2020.01.005\">10.1016/j.ydbio.2020.01.005</a>","chicago":"Cohn, Jesse A., Elizabeth R. Cebul, Giulio Valperga, Lotti Brose, Mario de Bono, Maxwell G. Heiman, and Jonathan T. Pierce. “Long-Term Activity Drives Dendritic Branch Elaboration of a C. Elegans Sensory Neuron.” <i>Developmental Biology</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.ydbio.2020.01.005\">https://doi.org/10.1016/j.ydbio.2020.01.005</a>.","ista":"Cohn JA, Cebul ER, Valperga G, Brose L, de Bono M, Heiman MG, Pierce JT. 2020. Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron. Developmental Biology. 461(1), 66–74."},"doi":"10.1016/j.ydbio.2020.01.005","author":[{"first_name":"Jesse A.","last_name":"Cohn","full_name":"Cohn, Jesse A."},{"first_name":"Elizabeth R.","full_name":"Cebul, Elizabeth R.","last_name":"Cebul"},{"full_name":"Valperga, Giulio","last_name":"Valperga","first_name":"Giulio"},{"last_name":"Brose","full_name":"Brose, Lotti","first_name":"Lotti"},{"last_name":"de Bono","full_name":"de Bono, Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","first_name":"Mario","orcid":"0000-0001-8347-0443"},{"first_name":"Maxwell G.","full_name":"Heiman, Maxwell G.","last_name":"Heiman"},{"full_name":"Pierce, Jonathan T.","last_name":"Pierce","first_name":"Jonathan T."}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","month":"05","date_updated":"2021-01-12T08:14:06Z","publisher":"Elsevier","year":"2020","publication":"Developmental Biology","publication_identifier":{"issn":["0012-1606"]},"title":"Long-term activity drives dendritic branch elaboration of a C. elegans sensory neuron","_id":"7545","day":"01","oa":1,"date_created":"2020-02-28T10:38:32Z","publication_status":"published","issue":"1","date_published":"2020-05-01T00:00:00Z","article_processing_charge":"No","quality_controlled":"1","article_type":"original","abstract":[{"lang":"eng","text":"Neuronal activity often leads to alterations in gene expression and cellular architecture. The nematode Caenorhabditis elegans, owing to its compact translucent nervous system, is a powerful system in which to study conserved aspects of the development and plasticity of neuronal morphology. Here we focus on one pair of sensory neurons, termed URX, which the worm uses to sense and avoid high levels of environmental oxygen. Previous studies have reported that the URX neuron pair has variable branched endings at its dendritic sensory tip. By controlling oxygen levels and analyzing mutants, we found that these microtubule-rich branched endings grow over time as a consequence of neuronal activity in adulthood. We also find that the growth of these branches correlates with an increase in cellular sensitivity to particular ranges of oxygen that is observable in the behavior of older worms. Given the strengths of C. elegans as a model organism, URX may serve as a potent system for uncovering genes and mechanisms involved in activity-dependent morphological changes in neurons and possible adaptive changes in the aging nervous system."}],"language":[{"iso":"eng"}],"page":"66-74","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/685339"}],"oa_version":"Preprint","type":"journal_article","status":"public","extern":"1","intvolume":"       461","volume":461},{"publication_status":"published","issue":"1","date_created":"2018-12-11T12:07:11Z","day":"01","_id":"4141","OA_type":"free access","title":"Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation","publication_identifier":{"issn":["0012-1606"]},"year":"2008","publisher":"Elsevier","date_updated":"2026-05-29T08:31:06Z","publication":"Developmental Biology","month":"08","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","author":[{"last_name":"Vervenne","full_name":"Vervenne, Hilke","first_name":"Hilke"},{"full_name":"Crombez, Koen","last_name":"Crombez","first_name":"Koen"},{"last_name":"Lambaerts","full_name":"Lambaerts, Kathleen","first_name":"Kathleen"},{"first_name":"Lara","full_name":"Carvalho, Lara","last_name":"Carvalho"},{"first_name":"Mathias","full_name":"Köppen, Mathias","last_name":"Köppen"},{"orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg"},{"first_name":"Wim","full_name":"Van De Ven, Wim","last_name":"Van De Ven"},{"last_name":"Petit","full_name":"Petit, Marleen","first_name":"Marleen"}],"publist_id":"1978","doi":"10.1016/j.ydbio.2008.05.529","citation":{"ista":"Vervenne H, Crombez K, Lambaerts K, Carvalho L, Köppen M, Heisenberg C-PJ, Van De Ven W, Petit M. 2008. Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. Developmental Biology. 320(1), 267–277.","ama":"Vervenne H, Crombez K, Lambaerts K, et al. Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. <i>Developmental Biology</i>. 2008;320(1):267-277. doi:<a href=\"https://doi.org/10.1016/j.ydbio.2008.05.529\">10.1016/j.ydbio.2008.05.529</a>","chicago":"Vervenne, Hilke, Koen Crombez, Kathleen Lambaerts, Lara Carvalho, Mathias Köppen, Carl-Philipp J Heisenberg, Wim Van De Ven, and Marleen Petit. “Lpp Is Involved in Wnt/PCP Signaling and Acts Together with Scrib to Mediate Convergence and Extension Movements during Zebrafish Gastrulation.” <i>Developmental Biology</i>. Elsevier, 2008. <a href=\"https://doi.org/10.1016/j.ydbio.2008.05.529\">https://doi.org/10.1016/j.ydbio.2008.05.529</a>.","mla":"Vervenne, Hilke, et al. “Lpp Is Involved in Wnt/PCP Signaling and Acts Together with Scrib to Mediate Convergence and Extension Movements during Zebrafish Gastrulation.” <i>Developmental Biology</i>, vol. 320, no. 1, Elsevier, 2008, pp. 267–77, doi:<a href=\"https://doi.org/10.1016/j.ydbio.2008.05.529\">10.1016/j.ydbio.2008.05.529</a>.","ieee":"H. Vervenne <i>et al.</i>, “Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation,” <i>Developmental Biology</i>, vol. 320, no. 1. Elsevier, pp. 267–277, 2008.","short":"H. Vervenne, K. Crombez, K. Lambaerts, L. Carvalho, M. Köppen, C.-P.J. Heisenberg, W. Van De Ven, M. Petit, Developmental Biology 320 (2008) 267–277.","apa":"Vervenne, H., Crombez, K., Lambaerts, K., Carvalho, L., Köppen, M., Heisenberg, C.-P. J., … Petit, M. (2008). Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation. <i>Developmental Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ydbio.2008.05.529\">https://doi.org/10.1016/j.ydbio.2008.05.529</a>"},"external_id":{"pmid":["18582857"]},"volume":320,"intvolume":"       320","type":"journal_article","status":"public","extern":"1","abstract":[{"text":"The zyxin-related LPP protein is localized at focal adhesions and cell-cell contacts and is involved in the regulation of smooth muscle cell migration. A known interaction partner of LPP in human is the tumor suppressor protein SCRIB. Knocking down scrib expression c uring zebrafish embryonic development results in defects of convergence and extension (C&amp;amp;E) movements, which occur during gastrulation and mediate elongation of the anterior-posterior body axis. Mediolateral cell polarization underlying C&amp;amp;E is regulated by a noncanonical Writ signaling pathway constituting the vertebrate planar cell polarity (PCP) pathway. Here, we investigated the role of Lpp during early zebrafish development. We show that morpholino knockdown of Ipp results in defects of C&amp;amp;E, phenocopying noncanonical Wnt signaling mutants. Time-lapse analysis associates the defective dorsal convergence movements with a reduced ability to migrate along straight paths. In addition, expression of Lpp is significantly reduced in Wnt11 morphants and in embryos overexpressing Wnt11 or a dominant-negative form of Rho kinase 2, which is a downstream effector of Wnt11, Suggesting that Lpp expression is dependent on noncanonical Wnt signaling. Finally, we demonstrate that Lpp interacts with the PCP protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of C&amp;amp;E. (C) 2008 Elsevier Inc. All rights reserved.","lang":"eng"}],"oa_version":"None","page":"267 - 277","language":[{"iso":"eng"}],"article_processing_charge":"No","article_type":"original","pmid":1,"date_published":"2008-08-01T00:00:00Z"}]