---
OA_type: closed access
_id: '20806'
abstract:
- lang: eng
  text: "Regulation of phosphatidylinositol phosphates plays a crucial role in signal
    transduction, membrane trafficking or autophagy. Members of the myotubularin family
    of lipid phosphatases contribute to phosphoinositide metabolism by counteracting
    the activity of phosphoinositide kinases. The mechanisms determining their subcellular
    localization and targeting to specific membrane compartments are still poorly
    understood.\r\nWe show here that the inactive phosphatase MTMR9 localizes to the
    intermediate compartment and to the Golgi apparatus and is able to recruit its
    active phosphatase partners MTMR6 and MTMR8 to these locations. Furthermore, MTMR8
    and MTMR9 co-localize with the small GTPase RAB1A and regulate its localization.
    Loss of MTMR9 expression compromises the integrity of the Golgi apparatus and
    results in altered distribution of RAB1A and actin nucleation-promoting factor
    WHAMM. Loss or overexpression of MTMR9 leads to decreased rate of protein secretion.
    We demonstrate that secretion of physiologically relevant cargo exemplified by
    the WNT3A protein is affected after perturbation of MTMR9 levels."
article_number: '111709'
article_processing_charge: No
article_type: original
author:
- first_name: Lenka
  full_name: Doubravská, Lenka
  last_name: Doubravská
- first_name: Vojtěch
  full_name: Dostál, Vojtěch
  last_name: Dostál
- first_name: Filip
  full_name: Knop, Filip
  id: 25f3131f-6e7c-11ef-8296-b64ccd4a1b69
  last_name: Knop
  orcid: 0000-0002-3845-3465
- first_name: Lenka
  full_name: Libusová, Lenka
  last_name: Libusová
- first_name: Marie
  full_name: Macůrková, Marie
  last_name: Macůrková
citation:
  ama: Doubravská L, Dostál V, Knop F, Libusová L, Macůrková M. Human myotubularin-related
    protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. <i>Experimental
    Cell Research</i>. 2020;386(1). doi:<a href="https://doi.org/10.1016/j.yexcr.2019.111709">10.1016/j.yexcr.2019.111709</a>
  apa: Doubravská, L., Dostál, V., Knop, F., Libusová, L., &#38; Macůrková, M. (2020).
    Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and modulates
    WNT3A secretion. <i>Experimental Cell Research</i>. Elsevier. <a href="https://doi.org/10.1016/j.yexcr.2019.111709">https://doi.org/10.1016/j.yexcr.2019.111709</a>
  chicago: Doubravská, Lenka, Vojtěch Dostál, Filip Knop, Lenka Libusová, and Marie
    Macůrková. “Human Myotubularin-Related Protein 9 Regulates ER-to-Golgi Trafficking
    and Modulates WNT3A Secretion.” <i>Experimental Cell Research</i>. Elsevier, 2020.
    <a href="https://doi.org/10.1016/j.yexcr.2019.111709">https://doi.org/10.1016/j.yexcr.2019.111709</a>.
  ieee: L. Doubravská, V. Dostál, F. Knop, L. Libusová, and M. Macůrková, “Human myotubularin-related
    protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion,” <i>Experimental
    Cell Research</i>, vol. 386, no. 1. Elsevier, 2020.
  ista: Doubravská L, Dostál V, Knop F, Libusová L, Macůrková M. 2020. Human myotubularin-related
    protein 9 regulates ER-to-Golgi trafficking and modulates WNT3A secretion. Experimental
    Cell Research. 386(1), 111709.
  mla: Doubravská, Lenka, et al. “Human Myotubularin-Related Protein 9 Regulates ER-to-Golgi
    Trafficking and Modulates WNT3A Secretion.” <i>Experimental Cell Research</i>,
    vol. 386, no. 1, 111709, Elsevier, 2020, doi:<a href="https://doi.org/10.1016/j.yexcr.2019.111709">10.1016/j.yexcr.2019.111709</a>.
  short: L. Doubravská, V. Dostál, F. Knop, L. Libusová, M. Macůrková, Experimental
    Cell Research 386 (2020).
date_created: 2025-12-12T09:03:03Z
date_published: 2020-01-01T00:00:00Z
date_updated: 2025-12-15T10:17:13Z
day: '01'
doi: 10.1016/j.yexcr.2019.111709
extern: '1'
external_id:
  pmid:
  - '31704058 '
intvolume: '       386'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
pmid: 1
publication: Experimental Cell Research
publication_identifier:
  issn:
  - 0014-4827
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Human myotubularin-related protein 9 regulates ER-to-Golgi trafficking and
  modulates WNT3A secretion
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 386
year: '2020'
...