---
_id: '7736'
abstract:
- lang: eng
text: We develop a novel approach to identify regions of the genome underlying population
genetic differentiation in any genetic data where the underlying population structure
is unknown, or where the interest is assessing divergence along a gradient. By
combining the statistical framework for genome-wide association studies (GWASs)
with eigenvector decomposition (EigenGWAS), which is commonly used in population
genetics to characterize the structure of genetic data, loci under selection can
be identified without a requirement for discrete populations. We show through
theory and simulation that our approach can identify regions under selection along
gradients of ancestry, and in real data we confirm this by demonstrating LCT to
be under selection between HapMap CEU–TSI cohorts, and we then validate this selection
signal across European countries in the POPRES samples. HERC2 was also found to
be differentiated between both the CEU–TSI cohort and within the POPRES sample,
reflecting the likely anthropological differences in skin and hair colour between
northern and southern European populations. Controlling for population stratification
is of great importance in any quantitative genetic study and our approach also
provides a simple, fast and accurate way of predicting principal components in
independent samples. With ever increasing sample sizes across many fields, this
approach is likely to be greatly utilized to gain individual-level eigenvectors
avoiding the computational challenges associated with conducting singular value
decomposition in large data sets. We have developed freely available software,
Genetic Analysis Repository (GEAR), to facilitate the application of the methods.
article_processing_charge: No
article_type: original
author:
- first_name: G-B
full_name: Chen, G-B
last_name: Chen
- first_name: S H
full_name: Lee, S H
last_name: Lee
- first_name: Z-X
full_name: Zhu, Z-X
last_name: Zhu
- first_name: B
full_name: Benyamin, B
last_name: Benyamin
- first_name: Matthew Richard
full_name: Robinson, Matthew Richard
id: E5D42276-F5DA-11E9-8E24-6303E6697425
last_name: Robinson
orcid: 0000-0001-8982-8813
citation:
ama: 'Chen G-B, Lee SH, Zhu Z-X, Benyamin B, Robinson MR. EigenGWAS: Finding loci
under selection through genome-wide association studies of eigenvectors in structured
populations. Heredity. 2016;117:51-61. doi:10.1038/hdy.2016.25'
apa: 'Chen, G.-B., Lee, S. H., Zhu, Z.-X., Benyamin, B., & Robinson, M. R. (2016).
EigenGWAS: Finding loci under selection through genome-wide association studies
of eigenvectors in structured populations. Heredity. Springer Nature. https://doi.org/10.1038/hdy.2016.25'
chicago: 'Chen, G-B, S H Lee, Z-X Zhu, B Benyamin, and Matthew Richard Robinson.
“EigenGWAS: Finding Loci under Selection through Genome-Wide Association Studies
of Eigenvectors in Structured Populations.” Heredity. Springer Nature,
2016. https://doi.org/10.1038/hdy.2016.25.'
ieee: 'G.-B. Chen, S. H. Lee, Z.-X. Zhu, B. Benyamin, and M. R. Robinson, “EigenGWAS:
Finding loci under selection through genome-wide association studies of eigenvectors
in structured populations,” Heredity, vol. 117. Springer Nature, pp. 51–61,
2016.'
ista: 'Chen G-B, Lee SH, Zhu Z-X, Benyamin B, Robinson MR. 2016. EigenGWAS: Finding
loci under selection through genome-wide association studies of eigenvectors in
structured populations. Heredity. 117, 51–61.'
mla: 'Chen, G. B., et al. “EigenGWAS: Finding Loci under Selection through Genome-Wide
Association Studies of Eigenvectors in Structured Populations.” Heredity,
vol. 117, Springer Nature, 2016, pp. 51–61, doi:10.1038/hdy.2016.25.'
short: G.-B. Chen, S.H. Lee, Z.-X. Zhu, B. Benyamin, M.R. Robinson, Heredity 117
(2016) 51–61.
date_created: 2020-04-30T10:50:03Z
date_published: 2016-05-04T00:00:00Z
date_updated: 2021-01-12T08:15:11Z
day: '04'
doi: 10.1038/hdy.2016.25
extern: '1'
intvolume: ' 117'
language:
- iso: eng
month: '05'
oa_version: None
page: 51-61
publication: Heredity
publication_identifier:
issn:
- 0018-067X
- 1365-2540
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: 'EigenGWAS: Finding loci under selection through genome-wide association studies
of eigenvectors in structured populations'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 117
year: '2016'
...
---
_id: '3624'
abstract:
- lang: eng
text: 'The state of a diploid population segregating for two alleles at each of
n loci is described by 22(n) genotype frequencies, or equivalently, by allele
frequencies and by multilocus moments or cumulants of various orders. These measures
of linkage disequilibrium cannot usually be determined, both because one cannot
tell whether a gene came from the maternal or paternal gamete, and because such
a large number of parameters cannot be estimated even from large samples. Simplifying
assumptions must therefore be made. This paper sets out methods for estimating
multilocus genotype frequencies which are appropriate for unlinked neutral loci,
and for populations that are ultimately derived by mixing of two source populations.
In such a hybrid population, all multilocus associations depend primarily on the
number of loci involved that derive from the maternal genome, and the number derived
from the paternal genome Allele frequencies may differ across loci, and the contribution
of each locus to multilocus associations may be scaled by the difference in allele
frequency between source populations for that locus (δp ≤ 1). For example, the
cumulant describing the association between genes i, j, k from the maternal genome,
and genes i, l from the paternal genome is K(tJ,k,iλ*), = δp(i)/2 δp(J) δp(k)
δp(l) κ3,2. The state of the population is described by n allele frequencies;
n divergences, δp; and by a symmetric matrix of cumulants, κ(J,K) (J = 0 ,...,
n, K = 0 ,..., n). Expressions for these cumulants under short- and long-range
migration are given. Two methods for estimating the cumulants are described: a
simple method based on multivariate moments, and a maximum likelihood procedure,
which uses the Metropolis algorithm. Both methods perform well when tested against
simulations with two or four loci.'
acknowledgement: This work was supported by grant MMI09726 from the BBSRC/EPSRC, and
by the Darwin Trust of Edinburgh. I am grateful to W. G. Hill, L. Kruuk and M. Orive,
and to the referees, for their helpful comments on the manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Estimating multilocus linkage disequilibria. Heredity. 2000;84(3):373-389.
doi:10.1046/j.1365-2540.2000.00683.x
apa: Barton, N. H. (2000). Estimating multilocus linkage disequilibria. Heredity.
Nature Publishing Group. https://doi.org/10.1046/j.1365-2540.2000.00683.x
chicago: Barton, Nicholas H. “Estimating Multilocus Linkage Disequilibria.” Heredity.
Nature Publishing Group, 2000. https://doi.org/10.1046/j.1365-2540.2000.00683.x.
ieee: N. H. Barton, “Estimating multilocus linkage disequilibria,” Heredity,
vol. 84, no. 3. Nature Publishing Group, pp. 373–389, 2000.
ista: Barton NH. 2000. Estimating multilocus linkage disequilibria. Heredity. 84(3),
373–389.
mla: Barton, Nicholas H. “Estimating Multilocus Linkage Disequilibria.” Heredity,
vol. 84, no. 3, Nature Publishing Group, 2000, pp. 373–89, doi:10.1046/j.1365-2540.2000.00683.x.
short: N.H. Barton, Heredity 84 (2000) 373–389.
date_created: 2018-12-11T12:04:18Z
date_published: 2000-03-01T00:00:00Z
date_updated: 2023-05-02T12:04:03Z
day: '01'
doi: 10.1046/j.1365-2540.2000.00683.x
extern: '1'
external_id:
pmid:
- '10762407'
intvolume: ' 84'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.nature.com/articles/6886830
month: '03'
oa_version: None
page: 373 - 389
pmid: 1
publication: Heredity
publication_identifier:
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2759'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Estimating multilocus linkage disequilibria
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 84
year: '2000'
...
---
_id: '4319'
abstract:
- lang: eng
text: The grasshopper Podisma pedestris contains two chromosomal races, which differ
by a Robertsonian fusion between the sex chromosome and an autosome, and which
meet in a narrow hybrid zone in the Alpes Maritimes. DNA content variation across
this hybrid zone was investigated by optical densitometry of Feulgen stained spermatids.
Spermatids from males with the unfused sex chromosome stain more strongly than
those from males with the fused chromosome. The difference between the karyotypes
is greater in the centre of the hybrid zone, suggesting that it is not a pleiotropic
effect of the fusion itself, but is due instead to differences at closely linked
loci.
acknowledgement: "s We would like to thank Manse East for technical assistance and
M. et Mme Aviotti for their hospitality in France. We are grateful to Dr Michael
Rennet, Dr Donald Fox, Professor Hubert Rees, and an anonymous referee for their
helpful comments on earlier manuscripts. This work was supported by an S.E.R.C.
grant to G.M.H., and by an S.E.R.C. postdoctoral fellowship to N.H.B. MW. worked
at UEA under an Outside Studies Program.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Michael
full_name: Westerman, Michael
last_name: Westerman
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Godfrey
full_name: Hewitt, Godfrey
last_name: Hewitt
citation:
ama: Westerman M, Barton NH, Hewitt G. Differences in DNA content between two chromosomal
races of the grasshopper Podisma pedestris. Heredity. 1987;58:221-228.
doi:10.1038/hdy.1987.36
apa: Westerman, M., Barton, N. H., & Hewitt, G. (1987). Differences in DNA content
between two chromosomal races of the grasshopper Podisma pedestris. Heredity.
Nature Publishing Group. https://doi.org/10.1038/hdy.1987.36
chicago: Westerman, Michael, Nicholas H Barton, and Godfrey Hewitt. “Differences
in DNA Content between Two Chromosomal Races of the Grasshopper Podisma Pedestris.”
Heredity. Nature Publishing Group, 1987. https://doi.org/10.1038/hdy.1987.36.
ieee: M. Westerman, N. H. Barton, and G. Hewitt, “Differences in DNA content between
two chromosomal races of the grasshopper Podisma pedestris,” Heredity,
vol. 58. Nature Publishing Group, pp. 221–228, 1987.
ista: Westerman M, Barton NH, Hewitt G. 1987. Differences in DNA content between
two chromosomal races of the grasshopper Podisma pedestris. Heredity. 58, 221–228.
mla: Westerman, Michael, et al. “Differences in DNA Content between Two Chromosomal
Races of the Grasshopper Podisma Pedestris.” Heredity, vol. 58, Nature
Publishing Group, 1987, pp. 221–28, doi:10.1038/hdy.1987.36.
short: M. Westerman, N.H. Barton, G. Hewitt, Heredity 58 (1987) 221–228.
date_created: 2018-12-11T12:08:14Z
date_published: 1987-01-01T00:00:00Z
date_updated: 2022-02-03T10:48:40Z
day: '01'
doi: 10.1038/hdy.1987.36
extern: '1'
intvolume: ' 58'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198736
month: '01'
oa: 1
oa_version: Published Version
page: 221 - 228
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '1733'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differences in DNA content between two chromosomal races of the grasshopper
Podisma pedestris
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 58
year: '1987'
...
---
_id: '3658'
abstract:
- lang: eng
text: Females of the grasshopper Podisima pedestris were collected from the middle
of a hybrid zone between two chromosomal races in the Alpes Maritimes. They had
already mated in the field, and could therefore lay fertilised eggs in the laboratory.
The embryos were karyotyped, and found to contain an excess of chromosomal homozygotes.
No evidence of assortative mating was found from copulating pairs taken in the
field. The excess appears to have been caused by a combination of multiple insemination
and assortative fertilisation. The genetics of the assortment, and the implications
for the evolution of reproductive isolation are discussed.
acknowledgement: "We are most grateful to Manse East for excellent technical assistance,
to Dr Michael Shaw and Martin Dransfield for statistical advice and to Dr Roger
Butlin for critical reading of the manuscript. It is a pleasure to thank M. and
Mme. Aviotti and family at Casterino for their help and hospitality over several
years of field work. The authorities of Le Parc National de Mercantour kindly gave
permission for the collections. This work was financed by grants from the N.E.R.C.
and S.E.R.C.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Godfrey
full_name: Hewitt, Godfrey
last_name: Hewitt
- first_name: R.
full_name: Nichols, R.
last_name: Nichols
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Hewitt G, Nichols R, Barton NH. Homogamy in a hybrid zone in the alpine grasshopper
Podisma pedestris. Heredity. 1987;59(3):457-466. doi:10.1038/hdy.1987.156
apa: Hewitt, G., Nichols, R., & Barton, N. H. (1987). Homogamy in a hybrid zone
in the alpine grasshopper Podisma pedestris. Heredity. Nature Publishing
Group. https://doi.org/10.1038/hdy.1987.156
chicago: Hewitt, Godfrey, R. Nichols, and Nicholas H Barton. “Homogamy in a Hybrid
Zone in the Alpine Grasshopper Podisma Pedestris.” Heredity. Nature Publishing
Group, 1987. https://doi.org/10.1038/hdy.1987.156.
ieee: G. Hewitt, R. Nichols, and N. H. Barton, “Homogamy in a hybrid zone in the
alpine grasshopper Podisma pedestris,” Heredity, vol. 59, no. 3. Nature
Publishing Group, pp. 457–466, 1987.
ista: Hewitt G, Nichols R, Barton NH. 1987. Homogamy in a hybrid zone in the alpine
grasshopper Podisma pedestris. Heredity. 59(3), 457–466.
mla: Hewitt, Godfrey, et al. “Homogamy in a Hybrid Zone in the Alpine Grasshopper
Podisma Pedestris.” Heredity, vol. 59, no. 3, Nature Publishing Group,
1987, pp. 457–66, doi:10.1038/hdy.1987.156.
short: G. Hewitt, R. Nichols, N.H. Barton, Heredity 59 (1987) 457–466.
date_created: 2018-12-11T12:04:28Z
date_published: 1987-12-01T00:00:00Z
date_updated: 2022-02-04T12:20:46Z
day: '01'
doi: 10.1038/hdy.1987.156
extern: '1'
intvolume: ' 59'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy1987156
month: '12'
oa: 1
oa_version: Published Version
page: 457 - 466
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2725'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Homogamy in a hybrid zone in the alpine grasshopper Podisma pedestris
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 59
year: '1987'
...
---
_id: '3663'
abstract:
- lang: eng
text: The conditional average frequency of rare alleles has been shown in simulations
to provide a simple and robust estimator of the number of individuals exchanged
between local populations in an island model (Nm). This statistic is defined as
the average frequency of an allele in those samples in which the allele is present.
Here, we show that the conditional average frequency can be calculated from the
distribution of allele frequencies. It is a measure of the spread of this distribution,
and so is analogous to the standardised variance, FST. Analytic predictions for
the island model of migration agree well with the corresponding simulation results.
These predictions are based on the assumption that the rare alleles found in samples
have reached a "quasi-equilibrium" distribution. As well as relating
the conditional average frequency to the underlying allele frequency distribution,
our results provide a more accurate method of estimating Nm from the conditional
average frequency of private alleles in samples of different sizes.
acknowledgement: This research has been supported in part by grants from the Royal
Society of London, S.E.R.C., and the National Science Foundation. We thank J. Felsenstein
for helpful discussions of this problem.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Montgomery
full_name: Slatkin, Montgomery
last_name: Slatkin
citation:
ama: Barton NH, Slatkin M. A quasi-equilibrium theory of the distribution of rare
alleles in a subdivided population. Heredity. 1986;56(3):409-416. doi:10.1038/hdy.1986.63
apa: Barton, N. H., & Slatkin, M. (1986). A quasi-equilibrium theory of the
distribution of rare alleles in a subdivided population. Heredity. Nature
Publishing Group. https://doi.org/10.1038/hdy.1986.63
chicago: Barton, Nicholas H, and Montgomery Slatkin. “A Quasi-Equilibrium Theory
of the Distribution of Rare Alleles in a Subdivided Population.” Heredity.
Nature Publishing Group, 1986. https://doi.org/10.1038/hdy.1986.63.
ieee: N. H. Barton and M. Slatkin, “A quasi-equilibrium theory of the distribution
of rare alleles in a subdivided population,” Heredity, vol. 56, no. 3.
Nature Publishing Group, pp. 409–416, 1986.
ista: Barton NH, Slatkin M. 1986. A quasi-equilibrium theory of the distribution
of rare alleles in a subdivided population. Heredity. 56(3), 409–416.
mla: Barton, Nicholas H., and Montgomery Slatkin. “A Quasi-Equilibrium Theory of
the Distribution of Rare Alleles in a Subdivided Population.” Heredity,
vol. 56, no. 3, Nature Publishing Group, 1986, pp. 409–16, doi:10.1038/hdy.1986.63.
short: N.H. Barton, M. Slatkin, Heredity 56 (1986) 409–416.
date_created: 2018-12-11T12:04:30Z
date_published: 1986-06-01T00:00:00Z
date_updated: 2022-02-01T15:04:01Z
day: '01'
doi: 10.1038/hdy.1986.63
extern: '1'
external_id:
pmid:
- '3733460 '
intvolume: ' 56'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198663
month: '06'
oa: 1
oa_version: None
page: 409 - 416
pmid: 1
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2720'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A quasi-equilibrium theory of the distribution of rare alleles in a subdivided
population
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 56
year: '1986'
...
---
_id: '3665'
abstract:
- lang: eng
text: The rate of gene flow across a hybrid zone may be reduced by the presence
of a physical barrier, by a reduction of population density caused by reduced
fitness of hybrids (the “hybrid sink” effect), and by linkage. If the reduction
in hybrid fitness is not extreme, the strength of the barrier to gene flow caused
by these effects is. Here, w is the width of the cline; ρ* is the carrying capacity;
W̄* is the mean fitness of the population, excluding effects of density; R is
the strength of density-dependent regulation; and r̄ is the harmonic mean recombination
rate between the locus whose flow is being calculated, and loci under selection.
+, 0 denote populations outside the hybrid zone, and at its centre, respectively.
This relation is illustrated using data from hybrid ones in Bombina and Podisma,
and its implications for interpretation of data from nature are discussed.
acknowledgement: I would like to thank Shahin Rouhani and Richard Nichols for their
helpful comments on the manuscript, and the latter for providing the data used in
fig. 3. This work was supported by a grant from the Science and Engineering Research
Council (GR/C/91529).
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The effects of linkage and density-dependent regulation on gene
flow. Heredity. 1986;57:415-426.
apa: Barton, N. H. (1986). The effects of linkage and density-dependent regulation
on gene flow. Heredity. Nature Publishing Group.
chicago: Barton, Nicholas H. “The Effects of Linkage and Density-Dependent Regulation
on Gene Flow.” Heredity. Nature Publishing Group, 1986.
ieee: N. H. Barton, “The effects of linkage and density-dependent regulation on
gene flow,” Heredity, vol. 57. Nature Publishing Group, pp. 415–426, 1986.
ista: Barton NH. 1986. The effects of linkage and density-dependent regulation on
gene flow. Heredity. 57, 415–426.
mla: Barton, Nicholas H. “The Effects of Linkage and Density-Dependent Regulation
on Gene Flow.” Heredity, vol. 57, Nature Publishing Group, 1986, pp. 415–26.
short: N.H. Barton, Heredity 57 (1986) 415–426.
date_created: 2018-12-11T12:04:30Z
date_published: 1986-01-01T00:00:00Z
date_updated: 2022-02-01T14:31:29Z
day: '01'
extern: '1'
intvolume: ' 57'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy1986142
month: '01'
oa: 1
oa_version: Published Version
page: 415 - 426
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2718'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The effects of linkage and density-dependent regulation on gene flow
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 57
year: '1986'
...
---
_id: '3664'
abstract:
- lang: eng
text: Suppose that selection acts at one or more loci to maintain genetic differences
between hybridising populations. Then, the flow of alleles at a neutral marker
locus which is linked to these selected loci will be impeded. We define and calculate
measures of the barrier to gene flow between two distinct demes, and across a
continuous habitat. In both cases, we find that in order for gene flow to be significantly
reduced over much of the genome, hybrids must be substantially less fit, and the
number of genes involved in building the barrier must be so large that the majority
of other genes become closely linked to some locus which is under selection. This
conclusion is not greatly affected by the pattern of epistasis, or the position
of the marker locus along the chromosome.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Bengt
full_name: Bengtsson, Bengt
last_name: Bengtsson
citation:
ama: Barton NH, Bengtsson B. The barrier to genetic exchange between hybridising
populations. Heredity. 1986;57:357-376.
apa: Barton, N. H., & Bengtsson, B. (1986). The barrier to genetic exchange
between hybridising populations. Heredity. Nature Publishing Group.
chicago: Barton, Nicholas H, and Bengt Bengtsson. “The Barrier to Genetic Exchange
between Hybridising Populations.” Heredity. Nature Publishing Group, 1986.
ieee: N. H. Barton and B. Bengtsson, “The barrier to genetic exchange between hybridising
populations,” Heredity, vol. 57. Nature Publishing Group, pp. 357–376,
1986.
ista: Barton NH, Bengtsson B. 1986. The barrier to genetic exchange between hybridising
populations. Heredity. 57, 357–376.
mla: Barton, Nicholas H., and Bengt Bengtsson. “The Barrier to Genetic Exchange
between Hybridising Populations.” Heredity, vol. 57, Nature Publishing
Group, 1986, pp. 357–76.
short: N.H. Barton, B. Bengtsson, Heredity 57 (1986) 357–376.
date_created: 2018-12-11T12:04:30Z
date_published: 1986-01-01T00:00:00Z
date_updated: 2022-02-01T14:49:02Z
day: '01'
extern: '1'
intvolume: ' 57'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy1986135
month: '01'
oa: 1
oa_version: Published Version
page: 357 - 376
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2719'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The barrier to genetic exchange between hybridising populations
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 57
year: '1986'
...
---
_id: '3667'
abstract:
- lang: eng
text: Populations of the grasshopper Podisma pedestris were collected from two ends
of a zone of hybridization between two chromosome races, at Seyne and Tende in
southern France. 21 enzyme and protein loci were detected by gel electrophoresis.
Six of these loci showed widespread polymorphism, and a further eleven had very
little or no variation. Two loci (Idh, 6Pgd) had rare alleles in different frequencies
in the two areas surveyed. The remaining two loci (Mdh-1, Mdh-2) showed a marked
increase in the frequency of rare variants, from 1 per cent outside the hybrid
zone, up to 5 per cent at its centre. This region of increased electrophoretic
variation coincided with the chromosomal cline between the two races, and with
a region of decreased viability. It was spread over about the same width as the
chromosomal cline. Possible explanations for this extra variation include intragenic
recombination and elevated mutation rates.
acknowledgement: We would like to thank Manse East, Lynda Flegg, and Sim Webb for
their excellent technical assistance, and Prof. J. M. Thoday for helpful comments.
Financial support was provided by a NERC Studentship to NHB, and a SRC grant to
GMH.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Bruce
full_name: Halliday, Bruce
last_name: Halliday
- first_name: Godfrey
full_name: Hewitt, Godfrey
last_name: Hewitt
citation:
ama: Barton NH, Halliday B, Hewitt G. Rare electrophoretic variants in a hybrid
zone. Heredity. 1983;50(2):139-146. doi:10.1038/hdy.1983.15
apa: Barton, N. H., Halliday, B., & Hewitt, G. (1983). Rare electrophoretic
variants in a hybrid zone. Heredity. Nature Publishing Group. https://doi.org/10.1038/hdy.1983.15
chicago: Barton, Nicholas H, Bruce Halliday, and Godfrey Hewitt. “Rare Electrophoretic
Variants in a Hybrid Zone.” Heredity. Nature Publishing Group, 1983. https://doi.org/10.1038/hdy.1983.15.
ieee: N. H. Barton, B. Halliday, and G. Hewitt, “Rare electrophoretic variants in
a hybrid zone,” Heredity, vol. 50, no. 2. Nature Publishing Group, pp.
139–146, 1983.
ista: Barton NH, Halliday B, Hewitt G. 1983. Rare electrophoretic variants in a
hybrid zone. Heredity. 50(2), 139–146.
mla: Barton, Nicholas H., et al. “Rare Electrophoretic Variants in a Hybrid Zone.”
Heredity, vol. 50, no. 2, Nature Publishing Group, 1983, pp. 139–46, doi:10.1038/hdy.1983.15.
short: N.H. Barton, B. Halliday, G. Hewitt, Heredity 50 (1983) 139–146.
date_created: 2018-12-11T12:04:31Z
date_published: 1983-04-01T00:00:00Z
date_updated: 2022-01-25T14:07:12Z
day: '01'
doi: 10.1038/hdy.1983.15
extern: '1'
intvolume: ' 50'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198315
month: '04'
oa: 1
oa_version: Published Version
page: 139 - 146
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2716'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Rare electrophoretic variants in a hybrid zone
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 50
year: '1983'
...
---
_id: '4330'
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Gene flow and speciation (abstract). Heredity. 1983;50:213-213.
doi:10.1038/hdy.1983.24
apa: 'Barton, N. H. (1983). Gene flow and speciation (abstract). Heredity.
University College of London: Springer Nature. https://doi.org/10.1038/hdy.1983.24'
chicago: 'Barton, Nicholas H. “Gene Flow and Speciation (Abstract).” Heredity.
University College of London: Springer Nature, 1983. https://doi.org/10.1038/hdy.1983.24.'
ieee: N. H. Barton, “Gene flow and speciation (abstract),” Heredity, vol.
50. Springer Nature, University College of London, pp. 213–213, 1983.
ista: Barton NH. 1983. Gene flow and speciation (abstract). Heredity. 50, 213–213.
mla: Barton, Nicholas H. “Gene Flow and Speciation (Abstract).” Heredity,
vol. 50, Springer Nature, 1983, pp. 213–213, doi:10.1038/hdy.1983.24.
short: N.H. Barton, Heredity 50 (1983) 213–213.
date_created: 2018-12-11T12:08:17Z
date_published: 1983-04-01T00:00:00Z
date_updated: 2022-01-21T12:38:10Z
day: '01'
doi: 10.1038/hdy.1983.24
extern: '1'
intvolume: ' 50'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198324
month: '04'
oa: 1
oa_version: Published Version
page: 213 - 213
place: University College of London
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Springer Nature
publist_id: '1704'
quality_controlled: '1'
status: public
title: Gene flow and speciation (abstract)
type: review
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 50
year: '1983'
...
---
_id: '3669'
abstract:
- lang: eng
text: The dispersal rate of the grasshopper Podisma pedestris has been measured,
with the aim of interpreting the width of a chromosomal cline. 171 adults were
marked individually, and released within the cline. 169 movements were seen over
three subsequent scorings; the distribution of distances, after correction for
the loss of long distance dispersants, was close to a normal curve, but there
was an initial shift of ten metres, perhaps towards a better habitat. The linear
variance increased at about 214 m2 day- 1, which corresponds to a standard deviation
of 207 m gen- 1/2 over a 20 day life span. Statistical uncertainty in this estimate
can be expressed using a distribution-free maximum likelihood method, which gives
support limits of 186- 270 m gen- 1/2. However, the main errors come from extrapolating
from this experiment to the cline as a whole.
acknowledgement: "We are grateful for the help in the field of Bruce and Helen Halliday,
James, Matthew, Daniel and Elizabeth Hewitt, and for the hospitality of M et Mme
Aviotti. This work was supported by an N.E.R.C. Studentship to the first author,
and an S.R.C. research grant to the second.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Godfrey
full_name: Hewitt, Godfrey
last_name: Hewitt
citation:
ama: 'Barton NH, Hewitt G. A measurement of dispersal in the grasshopper Podisma
pedestris (Orthoptera: Acrididae). Heredity. 1982;48(2):237-249. doi:10.1038/hdy.1982.29'
apa: 'Barton, N. H., & Hewitt, G. (1982). A measurement of dispersal in the
grasshopper Podisma pedestris (Orthoptera: Acrididae). Heredity. Springer
Nature. https://doi.org/10.1038/hdy.1982.29'
chicago: 'Barton, Nicholas H, and Godfrey Hewitt. “A Measurement of Dispersal in
the Grasshopper Podisma Pedestris (Orthoptera: Acrididae).” Heredity. Springer
Nature, 1982. https://doi.org/10.1038/hdy.1982.29.'
ieee: 'N. H. Barton and G. Hewitt, “A measurement of dispersal in the grasshopper
Podisma pedestris (Orthoptera: Acrididae),” Heredity, vol. 48, no. 2. Springer
Nature, pp. 237–249, 1982.'
ista: 'Barton NH, Hewitt G. 1982. A measurement of dispersal in the grasshopper
Podisma pedestris (Orthoptera: Acrididae). Heredity. 48(2), 237–249.'
mla: 'Barton, Nicholas H., and Godfrey Hewitt. “A Measurement of Dispersal in the
Grasshopper Podisma Pedestris (Orthoptera: Acrididae).” Heredity, vol.
48, no. 2, Springer Nature, 1982, pp. 237–49, doi:10.1038/hdy.1982.29.'
short: N.H. Barton, G. Hewitt, Heredity 48 (1982) 237–249.
date_created: 2018-12-11T12:04:32Z
date_published: 1982-04-01T00:00:00Z
date_updated: 2022-01-21T12:31:06Z
day: '01'
doi: 10.1038/hdy.1982.29
extern: '1'
intvolume: ' 48'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198229
month: '04'
oa: 1
oa_version: Published Version
page: 237 - 249
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Springer Nature
publist_id: '2714'
quality_controlled: '1'
status: public
title: 'A measurement of dispersal in the grasshopper Podisma pedestris (Orthoptera:
Acrididae)'
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 48
year: '1982'
...
---
_id: '3671'
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The width of the hybrid zone in Caledia captiva. Heredity.
1981;47:279-282. doi:10.1038/hdy.1981.86
apa: Barton, N. H. (1981). The width of the hybrid zone in Caledia captiva. Heredity.
Nature Publishing Group. https://doi.org/10.1038/hdy.1981.86
chicago: Barton, Nicholas H. “The Width of the Hybrid Zone in Caledia Captiva.”
Heredity. Nature Publishing Group, 1981. https://doi.org/10.1038/hdy.1981.86.
ieee: N. H. Barton, “The width of the hybrid zone in Caledia captiva,” Heredity,
vol. 47. Nature Publishing Group, pp. 279–282, 1981.
ista: Barton NH. 1981. The width of the hybrid zone in Caledia captiva. Heredity.
47, 279–282.
mla: Barton, Nicholas H. “The Width of the Hybrid Zone in Caledia Captiva.” Heredity,
vol. 47, Nature Publishing Group, 1981, pp. 279–82, doi:10.1038/hdy.1981.86.
short: N.H. Barton, Heredity 47 (1981) 279–282.
date_created: 2018-12-11T12:04:32Z
date_published: 1981-10-01T00:00:00Z
date_updated: 2022-01-21T08:42:28Z
day: '01'
doi: 10.1038/hdy.1981.86
extern: '1'
intvolume: ' 47'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198186
month: '10'
oa: 1
oa_version: Published Version
page: 279 - 282
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Nature Publishing Group
publist_id: '2712'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The width of the hybrid zone in Caledia captiva
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 47
year: '1981'
...
---
_id: '4333'
abstract:
- lang: eng
text: Samples were taken from five sites in a transect across the hybrid zone between
two chromosomal races of the grasshopper Podisma pedestris. Crosses were set up
between insects from the same population, and between populations spanning the
zone, and the early viability of the offspring was measured. Hybrids between pure
populations had reduced viability, and the viability of insects from the middle
of the zone was still lower, showing that most (87 per cent) of the inviability
was due to the breakup of coadapated gene complexes. Although the total selection
acting was strong (log. fitness reduced by S25), it was spread over a region wider
than the dispersal range (350 m vs. 20 m). Hence, the selection on each locus
contributing towards the inviability is weak (3 per cent). Many (150) independent
chromosome segments act cumulatively to produce inviability at this stage in the
life history. The implications of these findings for models of divergence are
discussed.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Godfrey
full_name: Hewitt, Godfrey
last_name: Hewitt
citation:
ama: Barton NH, Hewitt G. The genetic basis of hybrid inviability between two chromosomal
races of the grasshopper Podisma pedestris. Heredity. 1981;47(3):367-383.
doi:10.1038/hdy.1981.98
apa: Barton, N. H., & Hewitt, G. (1981). The genetic basis of hybrid inviability
between two chromosomal races of the grasshopper Podisma pedestris. Heredity.
Springer Nature. https://doi.org/10.1038/hdy.1981.98
chicago: Barton, Nicholas H, and Godfrey Hewitt. “The Genetic Basis of Hybrid Inviability
between Two Chromosomal Races of the Grasshopper Podisma Pedestris.” Heredity.
Springer Nature, 1981. https://doi.org/10.1038/hdy.1981.98.
ieee: N. H. Barton and G. Hewitt, “The genetic basis of hybrid inviability between
two chromosomal races of the grasshopper Podisma pedestris,” Heredity,
vol. 47, no. 3. Springer Nature, pp. 367–383, 1981.
ista: Barton NH, Hewitt G. 1981. The genetic basis of hybrid inviability between
two chromosomal races of the grasshopper Podisma pedestris. Heredity. 47(3), 367–383.
mla: Barton, Nicholas H., and Godfrey Hewitt. “The Genetic Basis of Hybrid Inviability
between Two Chromosomal Races of the Grasshopper Podisma Pedestris.” Heredity,
vol. 47, no. 3, Springer Nature, 1981, pp. 367–83, doi:10.1038/hdy.1981.98.
short: N.H. Barton, G. Hewitt, Heredity 47 (1981) 367–383.
date_created: 2018-12-11T12:08:18Z
date_published: 1981-12-01T00:00:00Z
date_updated: 2021-12-16T08:31:08Z
day: '01'
doi: 10.1038/hdy.1981.98
extern: '1'
intvolume: ' 47'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198198
month: '12'
oa: 1
oa_version: Published Version
page: 367 - 383
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Springer Nature
publist_id: '1703'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The genetic basis of hybrid inviability between two chromosomal races of the
grasshopper Podisma pedestris
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 47
year: '1981'
...
---
_id: '3672'
acknowledgement: This work was supported by a grant from the Natural Environment Research
Council.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The hybrid sink effect. Heredity. 1980;44:277-278. doi:10.1038/hdy.1980.23
apa: Barton, N. H. (1980). The hybrid sink effect. Heredity. Springer Nature.
https://doi.org/10.1038/hdy.1980.23
chicago: Barton, Nicholas H. “The Hybrid Sink Effect.” Heredity. Springer
Nature, 1980. https://doi.org/10.1038/hdy.1980.23.
ieee: N. H. Barton, “The hybrid sink effect,” Heredity, vol. 44. Springer
Nature, pp. 277–278, 1980.
ista: Barton NH. 1980. The hybrid sink effect. Heredity. 44, 277–278.
mla: Barton, Nicholas H. “The Hybrid Sink Effect.” Heredity, vol. 44, Springer
Nature, 1980, pp. 277–78, doi:10.1038/hdy.1980.23.
short: N.H. Barton, Heredity 44 (1980) 277–278.
date_created: 2018-12-11T12:04:33Z
date_published: 1980-04-01T00:00:00Z
date_updated: 2021-12-15T16:18:29Z
day: '01'
doi: 10.1038/hdy.1980.23
extern: '1'
intvolume: ' 44'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198023
month: '04'
oa: 1
oa_version: Published Version
page: 277 - 278
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Springer Nature
publist_id: '2711'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The hybrid sink effect
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 44
year: '1980'
...
---
_id: '4335'
abstract:
- lang: eng
text: Genetic incompatibilities between two races of the grasshopper Podisma pedestris,
which differ by a Robertsonian fusion involving the sex chromosome, have been
investigated. Crosses were made between four populations spanning the chromosomal
cline; F1 hybrids between the races, though not between separated populations
of the same race, showed markedly reduced hatching success. Observations of the
fate of chromosomes transplanted across the cline supported this finding. Crosses
between grasshoppers from a mixed population in the cline showed a lower average
hatching success, but no correlation of this inviability with the chromosomal
polymorphism. The karyotypes of pre-diapause embryos from both types of cross
gave no evidence for non-disjunction of the sex chromosome trivalent in heterozygous
females; an upper limit of 16 per cent can be set on the non-disjunction rate.
These findings suggest that the karyotypic difference is only a weakly selected
marker for more fundamental changes in genotype.
acknowledgement: I would like to thank Dr G. M. Hewitt, and M. W. Shaw, for their
help in collecting these samples, Mrs T. M. East for her help in rearing them, and
M et Mme Aviotti for their hospitality in France. This work was supported by a N.E.R.C.
studentship, and by an S.R.C. grant to Dr G. M. Hewitt.
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The fitness of hybrids between two chromosomal races of the grasshopper
Podisma pedestris. Heredity. 1980;45:47-59. doi:10.1038/hdy.1980.49
apa: Barton, N. H. (1980). The fitness of hybrids between two chromosomal races
of the grasshopper Podisma pedestris. Heredity. Springer Nature. https://doi.org/10.1038/hdy.1980.49
chicago: Barton, Nicholas H. “The Fitness of Hybrids between Two Chromosomal Races
of the Grasshopper Podisma Pedestris.” Heredity. Springer Nature, 1980.
https://doi.org/10.1038/hdy.1980.49.
ieee: N. H. Barton, “The fitness of hybrids between two chromosomal races of the
grasshopper Podisma pedestris,” Heredity, vol. 45. Springer Nature, pp.
47–59, 1980.
ista: Barton NH. 1980. The fitness of hybrids between two chromosomal races of the
grasshopper Podisma pedestris. Heredity. 45, 47–59.
mla: Barton, Nicholas H. “The Fitness of Hybrids between Two Chromosomal Races of
the Grasshopper Podisma Pedestris.” Heredity, vol. 45, Springer Nature,
1980, pp. 47–59, doi:10.1038/hdy.1980.49.
short: N.H. Barton, Heredity 45 (1980) 47–59.
date_created: 2018-12-11T12:08:19Z
date_published: 1980-08-01T00:00:00Z
date_updated: 2021-12-15T15:46:48Z
day: '01'
doi: 10.1038/hdy.1980.49
extern: '1'
intvolume: ' 45'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy198049
month: '08'
oa: 1
oa_version: Published Version
page: 47 - 59
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Springer Nature
publist_id: '1697'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The fitness of hybrids between two chromosomal races of the grasshopper Podisma
pedestris
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 45
year: '1980'
...
---
_id: '3673'
abstract:
- lang: eng
text: The effect of a cline as a barrier to gene flow at closely linked, weakly
selected loci is investigated using a continuous diffusion model. It is shown
that a linked cline induces a step in the frequency of a neutral allele, which
is proportional to the gradient in neutral allele frequency and to the inverse
of the recombination rate. A barrier to dispersal or a local region of low abundance
has a similar effect (Nagylaki, 1976). The cline will block the flow of neutral
alleles over a region of chromosome roughly 2s/t map units long. However, a slightly
advantageous allele will be little affected, and must be very tightly linked to
be delayed for long.
acknowledgement: "I would like to thank Dr G. M. Hewitt for stimulating discussions,
and for his comments on the manuscript. This work was supported by the Natural Environmental
Research Council.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Gene flow past a cline. Heredity. 1979;43(3):333-339. doi:10.1038/hdy.1979.86
apa: Barton, N. H. (1979). Gene flow past a cline. Heredity. Springer Nature.
https://doi.org/10.1038/hdy.1979.86
chicago: Barton, Nicholas H. “Gene Flow Past a Cline.” Heredity. Springer
Nature, 1979. https://doi.org/10.1038/hdy.1979.86.
ieee: N. H. Barton, “Gene flow past a cline,” Heredity, vol. 43, no. 3. Springer
Nature, pp. 333–339, 1979.
ista: Barton NH. 1979. Gene flow past a cline. Heredity. 43(3), 333–339.
mla: Barton, Nicholas H. “Gene Flow Past a Cline.” Heredity, vol. 43, no.
3, Springer Nature, 1979, pp. 333–39, doi:10.1038/hdy.1979.86.
short: N.H. Barton, Heredity 43 (1979) 333–339.
date_created: 2018-12-11T12:04:33Z
date_published: 1979-12-01T00:00:00Z
date_updated: 2021-12-15T15:16:50Z
day: '01'
doi: 10.1038/hdy.1979.86
extern: '1'
intvolume: ' 43'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.nature.com/articles/hdy197986
month: '12'
oa: 1
oa_version: Published Version
page: 333 - 339
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
- 0018-067X
publication_status: published
publisher: Springer Nature
publist_id: '2710'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Gene flow past a cline
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 43
year: '1979'
...
---
_id: '4336'
abstract:
- lang: eng
text: "This paper investigates the dynamic behaviour of hybrid zones which are maintained
by a balance between dispersal and selection against hybrids. In the first section
it is shown that a hybrid zone involving a single locus can move in response to
a selective imbalance between the two homozygotes, and also to variation in population
density and dispersal rate. It can be trapped by natural barriers, and so an allele
which is selected against when rare cannot advance, even if it is advantageous
when common. The continuous model used in deriving these results is shown to be
a good approximation to the stepping-stone model, provided that the cline contains
several demes.\r\n\r\nThe effect of stochastic forces on multi-locus hybrid zones
is then considered. An expression giving the shift in position after an arbitrary
perturbation in gamete frequency is derived. Using this formula, it is found that
sampling drift is negligible unless the zone includes few organisms and involves
few loci. Random variations in population structure are the dominant force, and
could allow considerable movement in an even environment. However, natural barriers
can still trap hybrid zones, and so it is likely that they will remain roughly
where they first formed."
article_processing_charge: No
article_type: original
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The dynamics of hybrid zones. Heredity. 1979;43(3):341-359.
doi:10.1038/hdy.1979.87
apa: Barton, N. H. (1979). The dynamics of hybrid zones. Heredity. Springer
Nature. https://doi.org/10.1038/hdy.1979.87
chicago: Barton, Nicholas H. “The Dynamics of Hybrid Zones.” Heredity. Springer
Nature, 1979. https://doi.org/10.1038/hdy.1979.87.
ieee: N. H. Barton, “The dynamics of hybrid zones,” Heredity, vol. 43, no.
3. Springer Nature, pp. 341–359, 1979.
ista: Barton NH. 1979. The dynamics of hybrid zones. Heredity. 43(3), 341–359.
mla: Barton, Nicholas H. “The Dynamics of Hybrid Zones.” Heredity, vol. 43,
no. 3, Springer Nature, 1979, pp. 341–59, doi:10.1038/hdy.1979.87.
short: N.H. Barton, Heredity 43 (1979) 341–359.
date_created: 2018-12-11T12:08:19Z
date_published: 1979-12-01T00:00:00Z
date_updated: 2021-12-15T09:29:59Z
day: '01'
doi: 10.1038/hdy.1979.87
extern: '1'
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issue: '3'
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month: '12'
oa: 1
oa_version: Published Version
page: 341 - 359
publication: Heredity
publication_identifier:
eissn:
- 1365-2540
issn:
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publication_status: published
publisher: Springer Nature
publist_id: '1696'
quality_controlled: '1'
status: public
title: The dynamics of hybrid zones
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 43
year: '1979'
...