@article{3466,
  abstract     = {Amphibian myelinated nerve fibers were treated with collagenase and protease. Axons with retraction of the myelin sheath were patch-clamped in the nodal and paranodal region. One type of Na channel was found. It has a single-channel conductance of 11 pS (15 degrees C) and is blocked by tetrodotoxin. Averaged events show the typical activation and inactivation kinetics of macroscopic Na current. Three potential-dependent K channels were identified (I, F, and S channel). The I channel, being the most frequent type, has a single-channel conductance of 23 pS (inward current, 105 mM K on both sides of the membrane), activates between -60 and -30 mV, deactivates with intermediate kinetics, and is sensitive to dendrotoxin. The F channel has a conductance of 30 pS, activates between -40 and 60 mV, and deactivates with fast kinetics. The former inactivates within tens of seconds; the latter inactivates within seconds. The third type, the S channel, has a conductance of 7 pS and deactivates slowly. All three channels can be blocked by external tetraethylammonium chloride. We suggest that these distinct K channel types form the basis for the different components of macroscopic K current described previously.},
  author       = {Jonas, Peter M and Bräu, Michael and Hermsteiner, Markus and Vogel, Werner},
  issn         = {1091-6490},
  journal      = {PNAS},
  number       = {18},
  pages        = {7238 -- 7242},
  publisher    = {National Academy of Sciences},
  title        = {{Single-channel recording in myelinated nerve fibers reveals one type of Na channel but different K channels}},
  doi          = {10.1073/pnas.86.18.7238},
  volume       = {86},
  year         = {1989},
}