---
_id: '3466'
abstract:
- lang: eng
  text: Amphibian myelinated nerve fibers were treated with collagenase and protease.
    Axons with retraction of the myelin sheath were patch-clamped in the nodal and
    paranodal region. One type of Na channel was found. It has a single-channel conductance
    of 11 pS (15 degrees C) and is blocked by tetrodotoxin. Averaged events show the
    typical activation and inactivation kinetics of macroscopic Na current. Three
    potential-dependent K channels were identified (I, F, and S channel). The I channel,
    being the most frequent type, has a single-channel conductance of 23 pS (inward
    current, 105 mM K on both sides of the membrane), activates between -60 and -30
    mV, deactivates with intermediate kinetics, and is sensitive to dendrotoxin. The
    F channel has a conductance of 30 pS, activates between -40 and 60 mV, and deactivates
    with fast kinetics. The former inactivates within tens of seconds; the latter
    inactivates within seconds. The third type, the S channel, has a conductance of
    7 pS and deactivates slowly. All three channels can be blocked by external tetraethylammonium
    chloride. We suggest that these distinct K channel types form the basis for the
    different components of macroscopic K current described previously.
acknowledgement: We thank Drs. C. Baumann, D. Siemen, and W. Stuhmer for reading the
  manuscript and Dr. F. Dreyer for the generous gift of DTX. The study was supported
  by the Deutsche Forschungsgemeinschaft.
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Michael
  full_name: Bräu, Michael
  last_name: Bräu
- first_name: Markus
  full_name: Hermsteiner, Markus
  last_name: Hermsteiner
- first_name: Werner
  full_name: Vogel, Werner
  last_name: Vogel
citation:
  ama: Jonas PM, Bräu M, Hermsteiner M, Vogel W. Single-channel recording in myelinated
    nerve fibers reveals one type of Na channel but different K channels. <i>PNAS</i>.
    1989;86(18):7238-7242. doi:<a href="https://doi.org/10.1073/pnas.86.18.7238">10.1073/pnas.86.18.7238</a>
  apa: Jonas, P. M., Bräu, M., Hermsteiner, M., &#38; Vogel, W. (1989). Single-channel
    recording in myelinated nerve fibers reveals one type of Na channel but different
    K channels. <i>PNAS</i>. National Academy of Sciences. <a href="https://doi.org/10.1073/pnas.86.18.7238">https://doi.org/10.1073/pnas.86.18.7238</a>
  chicago: Jonas, Peter M, Michael Bräu, Markus Hermsteiner, and Werner Vogel. “Single-Channel
    Recording in Myelinated Nerve Fibers Reveals One Type of Na Channel but Different
    K Channels.” <i>PNAS</i>. National Academy of Sciences, 1989. <a href="https://doi.org/10.1073/pnas.86.18.7238">https://doi.org/10.1073/pnas.86.18.7238</a>.
  ieee: P. M. Jonas, M. Bräu, M. Hermsteiner, and W. Vogel, “Single-channel recording
    in myelinated nerve fibers reveals one type of Na channel but different K channels,”
    <i>PNAS</i>, vol. 86, no. 18. National Academy of Sciences, pp. 7238–7242, 1989.
  ista: Jonas PM, Bräu M, Hermsteiner M, Vogel W. 1989. Single-channel recording in
    myelinated nerve fibers reveals one type of Na channel but different K channels.
    PNAS. 86(18), 7238–7242.
  mla: Jonas, Peter M., et al. “Single-Channel Recording in Myelinated Nerve Fibers
    Reveals One Type of Na Channel but Different K Channels.” <i>PNAS</i>, vol. 86,
    no. 18, National Academy of Sciences, 1989, pp. 7238–42, doi:<a href="https://doi.org/10.1073/pnas.86.18.7238">10.1073/pnas.86.18.7238</a>.
  short: P.M. Jonas, M. Bräu, M. Hermsteiner, W. Vogel, PNAS 86 (1989) 7238–7242.
date_created: 2018-12-11T12:03:28Z
date_published: 1989-09-01T00:00:00Z
date_updated: 2022-02-14T16:12:33Z
day: '01'
doi: 10.1073/pnas.86.18.7238
extern: '1'
external_id:
  pmid:
  - '2550937 '
intvolume: '        86'
issue: '18'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC298032/?tool=pubmed
month: '09'
oa: 1
oa_version: Published Version
page: 7238 - 7242
pmid: 1
publication: PNAS
publication_identifier:
  eissn:
  - 1091-6490
  issn:
  - 0027-8424
publication_status: published
publisher: National Academy of Sciences
publist_id: '2921'
quality_controlled: '1'
status: public
title: Single-channel recording in myelinated nerve fibers reveals one type of Na
  channel but different K channels
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 86
year: '1989'
...