@article{5767,
  abstract     = {Cuprate superconductors have long been thought of as having strong electronic correlations but negligible spin-orbit coupling. Using spin- and angle-resolved photoemission spectroscopy, we discovered that one of the most studied cuprate superconductors, Bi2212, has a nontrivial spin texture with a spin-momentum locking that circles the Brillouin zone center and a spin-layer locking that allows states of opposite spin to be localized in different parts of the unit cell. Our findings pose challenges for the vast majority of models of cuprates, such as the Hubbard model and its variants, where spin-orbit interaction has been mostly neglected, and open the intriguing question of how the high-temperature superconducting state emerges in the presence of this nontrivial spin texture. },
  author       = {Gotlieb, Kenneth and Lin, Chiu-Yun and Serbyn, Maksym and Zhang, Wentao and Smallwood, Christopher L. and Jozwiak, Christopher and Eisaki, Hiroshi and Hussain, Zahid and Vishwanath, Ashvin and Lanzara, Alessandra},
  issn         = {1095-9203},
  journal      = {Science},
  number       = {6420},
  pages        = {1271--1275},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Revealing hidden spin-momentum locking in a high-temperature cuprate superconductor}},
  doi          = {10.1126/science.aao0980},
  volume       = {362},
  year         = {2018},
}

@article{7718,
  abstract     = {Flores Island, Indonesia, was inhabited by the small-bodied hominin species Homo floresiensis, which has an unknown evolutionary relationship to modern humans. This island is also home to an extant human pygmy population. Here we describe genome-scale single-nucleotide polymorphism data and whole-genome sequences from a contemporary human pygmy population living on Flores near the cave where H. floresiensis was found. The genomes of Flores pygmies reveal a complex history of admixture with Denisovans and Neanderthals but no evidence for gene flow with other archaic hominins. Modern individuals bear the signatures of recent positive selection encompassing the FADS (fatty acid desaturase) gene cluster, likely related to diet, and polygenic selection acting on standing variation that contributed to their short-stature phenotype. Thus, multiple independent instances of hominin insular dwarfism occurred on Flores.},
  author       = {Tucci, Serena and Vohr, Samuel H. and McCoy, Rajiv C. and Vernot, Benjamin and Robinson, Matthew Richard and Barbieri, Chiara and Nelson, Brad J. and Fu, Wenqing and Purnomo, Gludhug A. and Sudoyo, Herawati and Eichler, Evan E. and Barbujani, Guido and Visscher, Peter M. and Akey, Joshua M. and Green, Richard E.},
  issn         = {0036-8075},
  journal      = {Science},
  number       = {6401},
  pages        = {511--516},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Evolutionary history and adaptation of a human pygmy population of Flores Island, Indonesia}},
  doi          = {10.1126/science.aar8486},
  volume       = {361},
  year         = {2018},
}

@article{7060,
  abstract     = {The anomalous metallic state in the high-temperature superconducting cuprates is masked by superconductivity near a quantum critical point. Applying high magnetic fields to suppress superconductivity has enabled detailed studies of the normal state, yet the direct effect of strong magnetic fields on the metallic state is poorly understood. We report the high-field magnetoresistance of thin-film La2–xSrxCuO4 cuprate in the vicinity of the critical doping, 0.161 ≤ p ≤ 0.190. We find that the metallic state exposed by suppressing superconductivity is characterized by magnetoresistance that is linear in magnetic fields up to 80 tesla. The magnitude of the linear-in-field resistivity mirrors the magnitude and doping evolution of the well-known linear-in-temperature resistivity that has been associated with quantum criticality in high-temperature superconductors.},
  author       = {Giraldo-Gallo, P. and Galvis, J. A. and Stegen, Z. and Modic, Kimberly A and Balakirev, F. F. and Betts, J. B. and Lian, X. and Moir, C. and Riggs, S. C. and Wu, J. and Bollinger, A. T. and He, X. and Božović, I. and Ramshaw, B. J. and McDonald, R. D. and Boebinger, G. S. and Shekhter, A.},
  issn         = {1095-9203},
  journal      = {Science},
  number       = {6401},
  pages        = {479--481},
  publisher    = {AAAS},
  title        = {{Scale-invariant magnetoresistance in a cuprate superconductor}},
  doi          = {10.1126/science.aan3178},
  volume       = {361},
  year         = {2018},
}

@article{1132,
  abstract     = {The hippocampus is thought to initiate systems-wide mnemonic processes through the reactivation of previously acquired spatial and episodic memory traces, which can recruit the entorhinal cortex as a first stage of memory redistribution to other brain areas. Hippocampal reactivation occurs during sharp wave-ripples, in which synchronous network firing encodes sequences of places.We investigated the coordination of this replay by recording assembly activity simultaneously in the CA1 region of the hippocampus and superficial layers of the medial entorhinal cortex. We found that entorhinal cell assemblies can replay trajectories independently of the hippocampus and sharp wave-ripples. This suggests that the hippocampus is not the sole initiator of spatial and episodic memory trace reactivation. Memory systems involved in these processes may include nonhierarchical, parallel components.},
  author       = {O'Neill, Joseph and Boccara, Charlotte and Stella, Federico and Schönenberger, Philipp and Csicsvari, Jozsef L},
  issn         = {0036-8075},
  journal      = {Science},
  number       = {6321},
  pages        = {184 -- 188},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Superficial layers of the medial entorhinal cortex replay independently of the hippocampus}},
  doi          = {10.1126/science.aag2787},
  volume       = {355},
  year         = {2017},
}

@article{13381,
  abstract     = {Self-assembly of inorganic nanoparticles has been used to prepare hundreds of different colloidal crystals, but almost invariably with the restriction that the particles must be densely packed. Here, we show that non–close-packed nanoparticle arrays can be fabricated through the selective removal of one of two components comprising binary nanoparticle superlattices. First, a variety of binary nanoparticle superlattices were prepared at the liquid-air interface, including several arrangements that were previously unknown. Molecular dynamics simulations revealed the particular role of the liquid in templating the formation of superlattices not achievable through self-assembly in bulk solution. Second, upon stabilization, all of these binary superlattices could be transformed into distinct “nanoallotropes”—nanoporous materials having the same chemical composition but differing in their nanoscale architectures.},
  author       = {Udayabhaskararao, Thumu and Altantzis, Thomas and Houben, Lothar and Coronado-Puchau, Marc and Langer, Judith and Popovitz-Biro, Ronit and Liz-Marzán, Luis M. and Vuković, Lela and Král, Petr and Bals, Sara and Klajn, Rafal},
  issn         = {1095-9203},
  journal      = {Science},
  keywords     = {Multidisciplinary},
  number       = {6362},
  pages        = {514--518},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Tunable porous nanoallotropes prepared by post-assembly etching of binary nanoparticle superlattices}},
  doi          = {10.1126/science.aan6046},
  volume       = {358},
  year         = {2017},
}

@article{13384,
  abstract     = {Although methane is a volatile gas, it can be efficiently trapped in ice, which can then be readily set on fire. Beyond the curiosity of this “burning ice,” caged methane is of great importance as one of the world's largest natural gas resources. In these materials, known as clathrates, methane molecules are tightly bound in nanometer-sized, regularly interspaced cages. Other inorganic materials, such as the silica mineral chibaite, can similarly encapsulate methane and higher hydrocarbons. Simple organic compounds have also been found to trap various organic molecules upon crystallization.},
  author       = {Samanta, Dipak and Klajn, Rafal},
  issn         = {1095-9203},
  journal      = {Science},
  keywords     = {Multidisciplinary},
  number       = {6328},
  pages        = {912--912},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Clathrates grow up}},
  doi          = {10.1126/science.aam7927},
  volume       = {355},
  year         = {2017},
}

@article{14008,
  abstract     = {Time-resolved x-ray absorption spectroscopy (TR-XAS) has so far practically been limited to large-scale facilities, to subpicosecond temporal resolution, and to the condensed phase. We report the realization of TR-XAS with a temporal resolution in the low femtosecond range by developing a tabletop high-harmonic source reaching up to 350 electron volts, thus partially covering the spectral region of 280 to 530 electron volts, where water is transmissive. We used this source to follow previously unexamined light-induced chemical reactions in the lowest electronic states of isolated CF4+ and SF6+ molecules in the gas phase. By probing element-specific core-to-valence transitions at the carbon K-edge or the sulfur L-edges, we characterized their reaction paths and observed the effect of symmetry breaking through the splitting of absorption bands and Rydberg-valence mixing induced by the geometry changes.},
  author       = {Pertot, Yoann and Schmidt, Cédric and Matthews, Mary and Chauvet, Adrien and Huppert, Martin and Svoboda, Vit and von Conta, Aaron and Tehlar, Andres and Baykusheva, Denitsa Rangelova and Wolf, Jean-Pierre and Wörner, Hans Jakob},
  issn         = {1095-9203},
  journal      = {Science},
  keywords     = {Multidisciplinary},
  number       = {6322},
  pages        = {264--267},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Time-resolved x-ray absorption spectroscopy with a water window high-harmonic source}},
  doi          = {10.1126/science.aah6114},
  volume       = {355},
  year         = {2017},
}

@article{14287,
  abstract     = {We describe an approach to bottom-up fabrication that allows integration of the functional diversity of proteins into designed three-dimensional structural frameworks. A set of custom staple proteins based on transcription activator–like effector proteins folds a double-stranded DNA template into a user-defined shape. Each staple protein is designed to recognize and closely link two distinct double-helical DNA sequences at separate positions on the template. We present design rules for constructing megadalton-scale DNA-protein hybrid shapes; introduce various structural motifs, such as custom curvature, corners, and vertices; and describe principles for creating multilayer DNA-protein objects with enhanced rigidity. We demonstrate self-assembly of our hybrid nanostructures in one-pot mixtures that include the genetic information for the designed proteins, the template DNA, RNA polymerase, ribosomes, and cofactors for transcription and translation.},
  author       = {Praetorius, Florian M and Dietz, Hendrik},
  issn         = {1095-9203},
  journal      = {Science},
  number       = {6331},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Self-assembly of genetically encoded DNA-protein hybrid nanoscale shapes}},
  doi          = {10.1126/science.aam5488},
  volume       = {355},
  year         = {2017},
}

@article{15156,
  abstract     = {Circadian clocks are ubiquitous timing systems that induce rhythms of biological activities in synchrony with night and day. In cyanobacteria, timing is generated by a posttranslational clock consisting of KaiA, KaiB, and KaiC proteins and a set of output signaling proteins, SasA and CikA, which transduce this rhythm to control gene expression. Here, we describe crystal and nuclear magnetic resonance structures of KaiB-KaiC,KaiA-KaiB-KaiC, and CikA-KaiB complexes. They reveal how the metamorphic properties of KaiB, a protein that adopts two distinct folds, and the post–adenosine triphosphate hydrolysis state of KaiC create a hub around which nighttime signaling events revolve, including inactivation of KaiA and reciprocal regulation of the mutually antagonistic signaling proteins, SasA and CikA.},
  author       = {Tseng, Roger and Goularte, Nicolette F. and Chavan, Archana and Luu, Jansen and Cohen, Susan E. and Chang, Yong-Gang and Heisler, Joel and Li, Sheng and Michael, Alicia Kathleen and Tripathi, Sarvind and Golden, Susan S. and LiWang, Andy and Partch, Carrie L.},
  issn         = {1095-9203},
  journal      = {Science},
  keywords     = {Multidisciplinary},
  number       = {6330},
  pages        = {1174--1180},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Structural basis of the day-night transition in a bacterial circadian clock}},
  doi          = {10.1126/science.aag2516},
  volume       = {355},
  year         = {2017},
}

@article{611,
  abstract     = {Small RNAs (sRNAs) regulate genes in plants and animals. Here, we show that population-wide differences in color patterns in snapdragon flowers are caused by an inverted duplication that generates sRNAs. The complexity and size of the transcripts indicate that the duplication represents an intermediate on the pathway to microRNA evolution. The sRNAs repress a pigment biosynthesis gene, creating a yellow highlight at the site of pollinator entry. The inverted duplication exhibits steep clines in allele frequency in a natural hybrid zone, showing that the allele is under selection. Thus, regulatory interactions of evolutionarily recent sRNAs can be acted upon by selection and contribute to the evolution of phenotypic diversity.},
  author       = {Bradley, Desmond and Xu, Ping and Mohorianu, Irina and Whibley, Annabel and Field, David and Tavares, Hugo and Couchman, Matthew and Copsey, Lucy and Carpenter, Rosemary and Li, Miaomiao and Li, Qun and Xue, Yongbiao and Dalmay, Tamas and Coen, Enrico},
  issn         = {0036-8075},
  journal      = {Science},
  number       = {6365},
  pages        = {925 -- 928},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Evolution of flower color pattern through selection on regulatory small RNAs}},
  doi          = {10.1126/science.aao3526},
  volume       = {358},
  year         = {2017},
}

@article{18198,
  abstract     = {Higgs and Goldstone modes are collective excitations of the amplitude and phase of an order parameter that is related to the breaking of a continuous symmetry. We directly studied these modes in a supersolid quantum gas created by coupling a Bose-Einstein condensate to two optical cavities, whose field amplitudes form the real and imaginary parts of a U(1)-symmetric order parameter. Monitoring the cavity fields in real time allowed us to observe the dynamics of the associated Higgs and Goldstone modes and revealed their amplitude and phase nature. We used a spectroscopic method to measure their frequencies, and we gave a tunable mass to the Goldstone mode by exploring the crossover between continuous and discrete symmetry. Our experiments link spectroscopic measurements to the theoretical concept of Higgs and Goldstone modes.},
  author       = {Leonard, Julian and Morales, Andrea and Zupancic, Philip and Donner, Tobias and Esslinger, Tilman},
  issn         = {1095-9203},
  journal      = {Science},
  number       = {6369},
  pages        = {1415--1418},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Monitoring and manipulating Higgs and Goldstone modes in a supersolid quantum gas}},
  doi          = {10.1126/science.aan2608},
  volume       = {358},
  year         = {2017},
}

@article{943,
  abstract     = {Like many developing tissues, the vertebrate neural tube is patterned by antiparallel morphogen gradients. To understand how these inputs are interpreted, we measured morphogen signaling and target gene expression in mouse embryos and chick ex vivo assays. From these data, we derived and validated a characteristic decoding map that relates morphogen input to the positional identity of neural progenitors. Analysis of the observed responses indicates that the underlying interpretation strategy minimizes patterning errors in response to the joint input of noisy opposing gradients. We reverse-engineered a transcriptional network that provides a mechanistic basis for the observed cell fate decisions and accounts for the precision and dynamics of pattern formation. Together, our data link opposing gradient dynamics in a growing tissue to precise pattern formation.},
  author       = {Zagórski, Marcin P and Tabata, Yoji and Brandenberg, Nathalie and Lutolf, Matthias and Tkacik, Gasper and Bollenbach, Tobias and Briscoe, James and Kicheva, Anna},
  issn         = {0036-8075},
  journal      = {Science},
  number       = {6345},
  pages        = {1379 -- 1383},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Decoding of position in the developing neural tube from antiparallel morphogen gradients}},
  doi          = {10.1126/science.aam5887},
  volume       = {356},
  year         = {2017},
}

@article{665,
  abstract     = {The molecular mechanisms underlying phenotypic variation in isogenic bacterial populations remain poorly understood.We report that AcrAB-TolC, the main multidrug efflux pump of Escherichia coli, exhibits a strong partitioning bias for old cell poles by a segregation mechanism that is mediated by ternary AcrAB-TolC complex formation. Mother cells inheriting old poles are phenotypically distinct and display increased drug efflux activity relative to daughters. Consequently, we find systematic and long-lived growth differences between mother and daughter cells in the presence of subinhibitory drug concentrations. A simple model for biased partitioning predicts a population structure of long-lived and highly heterogeneous phenotypes. This straightforward mechanism of generating sustained growth rate differences at subinhibitory antibiotic concentrations has implications for understanding the emergence of multidrug resistance in bacteria.},
  author       = {Bergmiller, Tobias and Andersson, Anna M and Tomasek, Kathrin and Balleza, Enrique and Kiviet, Daniel and Hauschild, Robert and Tkacik, Gasper and Guet, Calin C},
  issn         = {0036-8075},
  journal      = {Science},
  number       = {6335},
  pages        = {311 -- 315},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity}},
  doi          = {10.1126/science.aaf4762},
  volume       = {356},
  year         = {2017},
}

@techreport{587,
  abstract     = {Quantum metrology exploits entangled states of particles to improve sensing precision beyond the limit achievable with uncorrelated particles. All previous methods required detection noise levels below this standard quantum limit to realize the benefits of the intrinsic sensitivity provided by these states.We experimentally demonstrate a widely applicable method for entanglement-enhanced measurements without low-noise detection. The method involves an intermediate quantum phase magnification step that eases implementation complexity. We used it to perform squeezed-state metrology 8 decibels below the standard quantum limit with a detection system that has a noise floor 10 decibels above the standard quantum limit.},
  author       = {Hosten, Onur and Krishnakumar, Rajiv and Engelsen, Nils and Kasevich, Mark},
  issn         = {0036-8075},
  pages        = {1552 -- 1555},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Quantum phase magnification}},
  doi          = {10.1126/science.aaf3397},
  volume       = {352},
  year         = {2016},
}

@techreport{816,
  abstract     = {Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic cleavage of the viral Gag polyprotein induces structural maturation. Maturation can be blocked by maturation inhibitors (MIs), thereby abolishing infectivity. The CA (capsid) and SP1 (spacer peptide 1) region of Gag is the key regulator of assembly and maturation and is the target of MIs.We applied optimized cryo-electron tomography and subtomogram averaging to resolve this region within assembled immature HIV-1 particles at 3.9 angstrom resolution and built an atomic model. The structure reveals a network of intra- And intermolecular interactions mediating immature HIV-1 assembly. The proteolytic cleavage site between CA and SP1 is inaccessible to protease.We suggest that MIs prevent CA-SP1 cleavage by stabilizing the structure, and MI resistance develops by destabilizing CA-SP1.},
  author       = {Schur, Florian and Obr, Martin and Hagen, Wim and Wan, William and Jakobi, Arjen and Kirkpatrick, Joanna and Sachse, Carsten and Kraüsslich, Hans and Briggs, John},
  issn         = {1095-9203},
  pages        = {506 -- 508},
  publisher    = {American Association for the Advancement of Science},
  title        = {{An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly and maturation}},
  doi          = {10.1126/science.aaf9620},
  volume       = {353},
  year         = {2016},
}

@article{14013,
  abstract     = {The ultrafast motion of electrons and holes after light-matter interaction is fundamental to a broad range of chemical and biophysical processes. We advanced high-harmonic spectroscopy to resolve spatially and temporally the migration of an electron hole immediately after ionization of iodoacetylene while simultaneously demonstrating extensive control over the process. A multidimensional approach, based on the measurement and accurate theoretical description of both even and odd harmonic orders, enabled us to reconstruct both quantum amplitudes and phases of the electronic states with a resolution of ~100 attoseconds. We separately reconstructed quasi-field-free and laser-controlled charge migration as a function of the spatial orientation of the molecule and determined the shape of the hole created by ionization. Our technique opens the prospect of laser control over electronic primary processes.},
  author       = {Kraus, P. M. and Mignolet, B. and Baykusheva, Denitsa Rangelova and Rupenyan, A. and Horný, L. and Penka, E. F. and Grassi, G. and Tolstikhin, O. I. and Schneider, J. and Jensen, F. and Madsen, L. B. and Bandrauk, A. D. and Remacle, F. and Wörner, H. J.},
  issn         = {1095-9203},
  journal      = {Science},
  keywords     = {Multidisciplinary},
  number       = {6262},
  pages        = {790--795},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Measurement and laser control of attosecond charge migration in ionized iodoacetylene}},
  doi          = {10.1126/science.aab2160},
  volume       = {350},
  year         = {2015},
}

@article{2229,
  abstract     = {The distance between Ca^2+ channels and release sensors determines the speed and efficacy of synaptic transmission. Tight "nanodomain" channel-sensor coupling initiates transmitter release at synapses in the mature brain, whereas loose "microdomain" coupling appears restricted to early developmental stages. To probe the coupling configuration at a plastic synapse in the mature central nervous system, we performed paired recordings between mossy fiber terminals and CA3 pyramidal neurons in rat hippocampus. Millimolar concentrations of both the fast Ca^2+ chelator BAPTA [1,2-bis(2-aminophenoxy)ethane- N,N, N′,N′-tetraacetic acid] and the slow chelator EGTA efficiently suppressed transmitter release, indicating loose coupling between Ca^2+ channels and release sensors. Loose coupling enabled the control of initial release probability by fast endogenous Ca^2+ buffers and the generation of facilitation by buffer saturation. Thus, loose coupling provides the molecular framework for presynaptic plasticity.},
  author       = {Vyleta, Nicholas and Jonas, Peter M},
  issn         = {0036-8075},
  journal      = {Science},
  number       = {6171},
  pages        = {665 -- 670},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Loose coupling between Ca^2+ channels and release sensors at a plastic hippocampal synapse}},
  doi          = {10.1126/science.1244811},
  volume       = {343},
  year         = {2014},
}

@article{13400,
  abstract     = {Organizing inorganic nanocrystals into complex architectures is challenging and typically relies on preexisting templates, such as properly folded DNA or polypeptide chains. We found that under carefully controlled conditions, cubic nanocrystals of magnetite self-assemble into arrays of helical superstructures in a template-free manner with >99% yield. Computer simulations revealed that the formation of helices is determined by the interplay of van der Waals and magnetic dipole-dipole interactions, Zeeman coupling, and entropic forces and can be attributed to spontaneous formation of chiral nanocube clusters. Neighboring helices within their densely packed ensembles tended to adopt the same handedness in order to maximize packing, thus revealing a novel mechanism of symmetry breaking and chirality amplification.},
  author       = {Singh, Gurvinder and Chan, Henry and Baskin, Artem and Gelman, Elijah and Repnin, Nikita and Král, Petr and Klajn, Rafal},
  issn         = {1095-9203},
  journal      = {Science},
  keywords     = {Multidisciplinary},
  number       = {6201},
  pages        = {1149--1153},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Self-assembly of magnetite nanocubes into helical superstructures}},
  doi          = {10.1126/science.1254132},
  volume       = {345},
  year         = {2014},
}

@article{9055,
  abstract     = {Spontaneous formation of colonies of bacteria or flocks of birds are examples of self-organization in active living matter. Here, we demonstrate a form of self-organization from nonequilibrium driving forces in a suspension of synthetic photoactivated colloidal particles. They lead to two-dimensional "living crystals," which form, break, explode, and re-form elsewhere. The dynamic assembly results from a competition between self-propulsion of particles and an attractive interaction induced respectively by osmotic and phoretic effects and activated by light. We measured a transition from normal to giant-number fluctuations. Our experiments are quantitatively described by simple numerical simulations. We show that the existence of the living crystals is intrinsically related to the out-of-equilibrium collisions of the self-propelled particles.},
  author       = {Palacci, Jérémie A and Sacanna, S. and Steinberg, A. P. and Pine, D. J. and Chaikin, P. M.},
  issn         = {1095-9203},
  journal      = {Science},
  keywords     = {Multidisciplinary},
  number       = {6122},
  pages        = {936--940},
  publisher    = {American Association for the Advancement of Science },
  title        = {{Living crystals of light-activated colloidal surfers}},
  doi          = {10.1126/science.1230020},
  volume       = {339},
  year         = {2013},
}

@article{11092,
  abstract     = {To combat the functional decline of the proteome, cells use the process of protein turnover to replace potentially impaired polypeptides with new functional copies. We found that extremely long-lived proteins (ELLPs) did not turn over in postmitotic cells of the rat central nervous system. These ELLPs were associated with chromatin and the nuclear pore complex, the central transport channels that mediate all molecular trafficking in and out of the nucleus. The longevity of these proteins would be expected to expose them to potentially harmful metabolites, putting them at risk of accumulating damage over extended periods of time. Thus, it is possible that failure to maintain proper levels and functional integrity of ELLPs in nonproliferative cells might contribute to age-related deterioration in cell and tissue function.},
  author       = {Savas, Jeffrey N. and Toyama, Brandon H. and Xu, Tao and Yates, John R. and HETZER, Martin W},
  issn         = {1095-9203},
  journal      = {Science},
  number       = {6071},
  pages        = {942--942},
  publisher    = {American Association for the Advancement of Science},
  title        = {{Extremely long-lived nuclear pore proteins in the rat brain}},
  doi          = {10.1126/science.1217421},
  volume       = {335},
  year         = {2012},
}