[{"publication":"Science","article_processing_charge":"No","quality_controlled":"1","language":[{"iso":"eng"}],"publisher":"AAAS","month":"04","pmid":1,"article_number":"eaea6343","intvolume":"       392","date_published":"2026-04-16T00:00:00Z","citation":{"ama":"Springstein BL, Javoor M, Megrian D, et al. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. 2026;392(6795). doi:<a href=\"https://doi.org/10.1126/science.aea6343\">10.1126/science.aea6343</a>","chicago":"Springstein, Benjamin L, Manjunath Javoor, Daniela Megrian, Roman Hajdu, Dustin M. Hanke, Bettina Zens, Gregor L. Weiss, Florian KM Schur, and Martin Loose. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.aea6343\">https://doi.org/10.1126/science.aea6343</a>.","ieee":"B. L. Springstein <i>et al.</i>, “Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape,” <i>Science</i>, vol. 392, no. 6795. AAAS, 2026.","mla":"Springstein, Benjamin L., et al. “Repurposing of a DNA Segregation Machinery into a Cytoskeletal System Controlling Cell Shape.” <i>Science</i>, vol. 392, no. 6795, eaea6343, AAAS, 2026, doi:<a href=\"https://doi.org/10.1126/science.aea6343\">10.1126/science.aea6343</a>.","ista":"Springstein BL, Javoor M, Megrian D, Hajdu R, Hanke DM, Zens B, Weiss GL, Schur FK, Loose M. 2026. Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. Science. 392(6795), eaea6343.","apa":"Springstein, B. L., Javoor, M., Megrian, D., Hajdu, R., Hanke, D. M., Zens, B., … Loose, M. (2026). Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aea6343\">https://doi.org/10.1126/science.aea6343</a>","short":"B.L. Springstein, M. Javoor, D. Megrian, R. Hajdu, D.M. Hanke, B. Zens, G.L. Weiss, F.K. Schur, M. Loose, Science 392 (2026)."},"status":"public","date_created":"2026-04-26T22:01:46Z","doi":"10.1126/science.aea6343","acknowledgement":"We thank all members of the Loose lab at ISTA for helpful discussions; M. Kojic for critical reading of the manuscript; A. Herrero (Sevilla University) for sharing her extensive BACTH plasmid library and other plasmids, as well as cyanobacterial strains; T. Dagan and F. Nies (both Kiel University) for sharing cyanobacterial strains and plasmids and for valuable discussions; N. Sapay and A. Michon for providing the Amphipaseek code, which enabled us to perform our large-scale amphipathic helix screen of cyanobacterial CorR proteins; V.-V. Hodirnau for support in cryo-ET data collection; and J. Hansen for advice about cryo-EM data processing.\r\nThis work was supported by the Scientific Service Units (SSU) of ISTA through resources provided by the Imaging & Optics Facility (IOF), the Scientific Computing (SciComp), the Electron Microscopy Facility (EMF), and the Lab Support Facility (LSF). This work was funded by the European Union’s Horizon 2020 research and innovation program (Marie Skłodowska-Curie grant 101034413 to B.L.S.); the European Research Council (ERC) of the European Union (grant ActinID 101076260 to F.K.M.S.); the Swiss National Science Foundation (starting grant TMSGI3_226208 to G.L.W.); and the Jean-Jacques et Letitia Lopez-Loreta Foundation (G.L.W.).","day":"16","type":"journal_article","OA_type":"closed access","issue":"6795","title":"Repurposing of a DNA segregation machinery into a cytoskeletal system controlling cell shape","corr_author":"1","scopus_import":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"author":[{"first_name":"Benjamin L","last_name":"Springstein","orcid":"0000-0002-3461-5391","full_name":"Springstein, Benjamin L","id":"b4eb62ef-ac72-11ed-9503-ed3b4d66c083"},{"full_name":"Javoor, Manjunath","orcid":"0000-0003-2311-2112","id":"305ab18b-dc7d-11ea-9b2f-b58195228ea2","first_name":"Manjunath","last_name":"Javoor"},{"first_name":"Daniela","last_name":"Megrian","full_name":"Megrian, Daniela"},{"first_name":"Roman","last_name":"Hajdu","full_name":"Hajdu, Roman","id":"ffab949d-133f-11ed-8f02-94de21ace503"},{"last_name":"Hanke","first_name":"Dustin M.","full_name":"Hanke, Dustin M."},{"full_name":"Zens, Bettina","orcid":"0000-0002-9561-1239","id":"45FD126C-F248-11E8-B48F-1D18A9856A87","first_name":"Bettina","last_name":"Zens"},{"full_name":"Weiss, Gregor L.","first_name":"Gregor L.","last_name":"Weiss"},{"orcid":"0000-0003-4790-8078","full_name":"Schur, Florian Km","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","first_name":"Florian Km","last_name":"Schur"},{"last_name":"Loose","first_name":"Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","full_name":"Loose, Martin","orcid":"0000-0001-7309-9724"}],"external_id":{"pmid":["41990175"]},"abstract":[{"lang":"eng","text":"Bacteria, like eukaryotes, use conserved cytoskeletal systems for intracellular organization. The plasmid-encoded ParMRC system forms actin-like filaments that segregate low–copy number plasmids. In multicellular cyanobacteria such as Anabaena sp., we found that a chromosomally encoded ParMR system has evolved into a cytoskeletal system named CorMR with a function in cell shape control rather than DNA segregation. Live-cell imaging, in vitro reconstitution, and cryo–electron microscopy revealed that CorM formed dynamically unstable, antiparallel double-stranded filaments that were recruited to the membrane by CorR through an amphipathic helix conserved in multicellular cyanobacteria. CorMR filaments were regulated by MinC, which excluded them from the poles and division plane. Comparative genomics indicated that the repurposing of ParMR and Min systems coevolved with cyanobacterial multicellularity, highlighting the evolutionary plasticity of cytoskeletal systems in bacteria."}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"EM-Fac"},{"_id":"LifeSc"}],"department":[{"_id":"MaLo"},{"_id":"FlSc"},{"_id":"GradSch"},{"_id":"EM-Fac"}],"_id":"21762","ec_funded":1,"project":[{"_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","grant_number":"101034413","call_identifier":"H2020","name":"IST-BRIDGE: International postdoctoral program"},{"name":"A molecular atlas of Actin filament IDentities in the cell motility machinery","_id":"bd980d18-d553-11ed-ba76-ceaa645c97eb","grant_number":"101076260"}],"oa_version":"None","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2026","volume":392,"publication_status":"published","date_updated":"2026-04-28T13:29:05Z"},{"date_published":"2026-04-16T00:00:00Z","citation":{"ista":"Kulich I, Vladimirtsev D, Randuch M, Gao S, Citterico M, Konrad KR, Nagel G, Wrzaczek M, Cascaro L, Vinet P, Durand P, Asnacios A, Verma L, Bennett MJ, Pandey BK, Friml J. 2026. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. Science. 392(6795), 296–300.","apa":"Kulich, I., Vladimirtsev, D., Randuch, M., Gao, S., Citterico, M., Konrad, K. R., … Friml, J. (2026). Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adu8197\">https://doi.org/10.1126/science.adu8197</a>","short":"I. Kulich, D. Vladimirtsev, M. Randuch, S. Gao, M. Citterico, K.R. Konrad, G. Nagel, M. Wrzaczek, L. Cascaro, P. Vinet, P. Durand, A. Asnacios, L. Verma, M.J. Bennett, B.K. Pandey, J. Friml, Science 392 (2026) 296–300.","ama":"Kulich I, Vladimirtsev D, Randuch M, et al. Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation. <i>Science</i>. 2026;392(6795):296-300. doi:<a href=\"https://doi.org/10.1126/science.adu8197\">10.1126/science.adu8197</a>","chicago":"Kulich, Ivan, Dmitrii Vladimirtsev, Marek Randuch, Shiqiang Gao, Matteo Citterico, Kai R. Konrad, Georg Nagel, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” <i>Science</i>. AAAS, 2026. <a href=\"https://doi.org/10.1126/science.adu8197\">https://doi.org/10.1126/science.adu8197</a>.","ieee":"I. Kulich <i>et al.</i>, “Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation,” <i>Science</i>, vol. 392, no. 6795. AAAS, pp. 296–300, 2026.","mla":"Kulich, Ivan, et al. “Calcium-Triggered Apoplastic ROS Bursts Balance Gravity and Mechanical Signals for Soil Navigation.” <i>Science</i>, vol. 392, no. 6795, AAAS, 2026, pp. 296–300, doi:<a href=\"https://doi.org/10.1126/science.adu8197\">10.1126/science.adu8197</a>."},"intvolume":"       392","language":[{"iso":"eng"}],"publisher":"AAAS","OA_place":"repository","month":"04","pmid":1,"publication":"Science","article_processing_charge":"No","quality_controlled":"1","corr_author":"1","ddc":["580"],"scopus_import":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"OA_type":"green","title":"Calcium-triggered apoplastic ROS bursts balance gravity and mechanical signals for soil navigation","issue":"6795","acknowledgement":"We gratefully acknowledge the Lab Support Facility (LSF) and the Imaging and Optics Facility (IOF) (both of ISTA) and the Hounsfield CT Facility (University of Nottingham) for support with imaging and the Growth Facility (IPMB) for plant cultivation. We thank M. Fendrych and his team for help with the microfluidics upgrades and J. Atkinson at the University of Nottingham MakerSpace for 3D printing of Arabidopsis mini-soil columns.\r\nThis project received funding from the European Research Council (ERC; 101142681 CYNIPS) and the Austrian Science Fund (FWF; P 37051-B). I.K. was cofunded by the European Union, Horizon Europe, project MOLIPEC, ID 101087030 and CSF project 25-16449S. L.V. and B.K.P. acknowledge funding from UK Research and Innovation (UKRI) Frontiers Research (EP/Y036697/1). M.J.B. acknowledges funding from ERC SYNERGY (grant 101118769 HYDROSENSING). The study was partially supported by the Université Paris Cité, Idex ANR-18-IDEX-0001, funded by the French Government through its “Investments for the Future” program and also by the projects “Mecha-Nuc” ANR-20-CE13-0025-03 and “scEm-bryoMech” ANR-21-CE13-0046. P.D. acknowledges support by Human Frontier Science Program Organization grant 2022-RG107. P.V. acknowledges support provided by “Programme blanc” of the Graduate School BIOSPHERA, Université Paris-Saclay. Phytohormonal analysis was performed using the service laboratory funded by Toward Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the European Regional Development Fund (ERDF) program Johannes Amos Comenius. This research was funded in whole or in part by the Austrian Science Fund (P 37051-B) and UK Research and Innovation (EP/Y036697/1), cOAlition S organizations, and by the European Research Council (101142681 CYNIPS, 101118769 HYDROSENSING); as required, the author will make the Author Accepted Manuscript (AAM) version available under a CC BY public copyright license.","type":"journal_article","day":"16","has_accepted_license":"1","status":"public","date_created":"2026-04-26T22:01:47Z","doi":"10.1126/science.adu8197","article_type":"original","page":"296-300","oa":1,"project":[{"name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"},{"grant_number":"P37051","_id":"7bcece63-9f16-11ee-852c-ae94e099eeb6","name":"Guanylate cyclase activity of TIR1/AFBs auxin receptors"}],"_id":"21763","oa_version":"Accepted Version","department":[{"_id":"JiFr"},{"_id":"GradSch"}],"author":[{"full_name":"Kulich, Ivan","id":"57a1567c-8314-11eb-9063-c9ddc3451a54","first_name":"Ivan","last_name":"Kulich"},{"first_name":"Dmitrii","last_name":"Vladimirtsev","full_name":"Vladimirtsev, Dmitrii","id":"60466724-5355-11ee-ae5a-fa55e8f99c3d"},{"id":"6ac4636d-15b2-11ec-abd3-fb8df79972ae","full_name":"Randuch, Marek","last_name":"Randuch","first_name":"Marek"},{"last_name":"Gao","first_name":"Shiqiang","full_name":"Gao, Shiqiang"},{"last_name":"Citterico","first_name":"Matteo","full_name":"Citterico, Matteo"},{"full_name":"Konrad, Kai R.","last_name":"Konrad","first_name":"Kai R."},{"last_name":"Nagel","first_name":"Georg","full_name":"Nagel, Georg"},{"full_name":"Wrzaczek, Michael","first_name":"Michael","last_name":"Wrzaczek"},{"last_name":"Cascaro","first_name":"Léa","full_name":"Cascaro, Léa"},{"last_name":"Vinet","first_name":"Pauline","full_name":"Vinet, Pauline"},{"full_name":"Durand, Pauline","last_name":"Durand","first_name":"Pauline"},{"first_name":"Atef","last_name":"Asnacios","full_name":"Asnacios, Atef"},{"first_name":"Lokesh","last_name":"Verma","full_name":"Verma, Lokesh"},{"last_name":"Bennett","first_name":"Malcolm J.","full_name":"Bennett, Malcolm J."},{"first_name":"Bipin K.","last_name":"Pandey","full_name":"Pandey, Bipin K."},{"first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"external_id":{"pmid":["41990180"]},"abstract":[{"lang":"eng","text":"Reactive oxygen species (ROS) have been implicated in multiple signaling processes in plants, but the underlying mechanisms and roles remain enigmatic. In this study, we developed a method of live imaging of apoplastic ROS at the root surface. Distinct signals, including auxin, extracellular adenosine triphosphate, and rapid alkalinization factor 1 peptide, induce cytosolic calcium transients and apoplastic ROS bursts. Genetic and optogenetic manipulations of Arabidopsis identified calcium transients as necessary and sufficient for ROS bursts through activation of reduced nicotinamide adenine dinucleotide phosphate (NADPH) oxidases RBOHC and RBOHF. Apoplastic ROS bursts are not required, but they do limit gravity-induced root bending. Root bending is sensed by the stretch-activated calcium channel MCA1, leading to NADPH oxidase activation. The resulting ROS production stiffens cell walls to facilitate soil penetration. Apoplastic ROS thus provides a means to balance tissue flexibility and stiffness to navigate soil."}],"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"file_date_updated":"2026-05-07T05:54:43Z","date_updated":"2026-05-07T06:20:07Z","volume":392,"year":"2026","publication_status":"published","file":[{"success":1,"creator":"dernst","checksum":"eb5b29247832ecdc53c8146da0509bbe","date_created":"2026-05-07T05:54:43Z","access_level":"open_access","file_size":6150733,"date_updated":"2026-05-07T05:54:43Z","relation":"main_file","content_type":"application/pdf","file_id":"21832","file_name":"2026_Science_Kulich_accepted.pdf"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"day":"16","type":"journal_article","acknowledgement":"The author thanks P. Jonas for feedback on the manuscript and acknowledges support from the European Union’s Horizon 2020 research and innovation program under Marie Skłodowska-Curie grant agreement no. 101034413.","doi":"10.1126/science.aec0091","date_created":"2025-10-26T23:01:34Z","status":"public","corr_author":"1","scopus_import":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"OA_type":"closed access","issue":"6770","title":"Kiss, shrink, run","pmid":1,"month":"10","language":[{"iso":"eng"}],"publisher":"AAAS","article_processing_charge":"No","quality_controlled":"1","publication":"Science","date_published":"2025-10-16T00:00:00Z","citation":{"mla":"Lichter, Katharina. “Kiss, Shrink, Run.” <i>Science</i>, vol. 390, no. 6770, AAAS, 2025, pp. 236–37, doi:<a href=\"https://doi.org/10.1126/science.aec0091\">10.1126/science.aec0091</a>.","ama":"Lichter K. Kiss, shrink, run. <i>Science</i>. 2025;390(6770):236-237. doi:<a href=\"https://doi.org/10.1126/science.aec0091\">10.1126/science.aec0091</a>","chicago":"Lichter, Katharina. “Kiss, Shrink, Run.” <i>Science</i>. AAAS, 2025. <a href=\"https://doi.org/10.1126/science.aec0091\">https://doi.org/10.1126/science.aec0091</a>.","ieee":"K. Lichter, “Kiss, shrink, run,” <i>Science</i>, vol. 390, no. 6770. AAAS, pp. 236–237, 2025.","short":"K. Lichter, Science 390 (2025) 236–237.","apa":"Lichter, K. (2025). Kiss, shrink, run. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.aec0091\">https://doi.org/10.1126/science.aec0091</a>","ista":"Lichter K. 2025. Kiss, shrink, run. Science. 390(6770), 236–237."},"intvolume":"       390","publication_status":"published","year":"2025","volume":390,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"date_updated":"2025-12-01T15:04:34Z","department":[{"_id":"PeJo"}],"abstract":[{"lang":"eng","text":"A unified mechanism directs synaptic vesicle release"}],"author":[{"id":"39302e62-fcfc-11ec-8196-8b01447dbd3d","orcid":"0000-0002-1485-0351","full_name":"Lichter, Katharina","last_name":"Lichter","first_name":"Katharina"}],"external_id":{"isi":["001610669900024"],"pmid":["41100630"]},"page":"236-237","article_type":"comment","oa_version":"None","ec_funded":1,"_id":"20532","project":[{"call_identifier":"H2020","grant_number":"101034413","_id":"fc2ed2f7-9c52-11eb-aca3-c01059dda49c","name":"IST-BRIDGE: International postdoctoral program"}]},{"quality_controlled":"1","article_processing_charge":"No","publication":"Science","pmid":1,"month":"12","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"intvolume":"       386","citation":{"mla":"Yao, Yuxing, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” <i>Science</i>, vol. 386, no. 6726, American Association for the Advancement of Science, 2024, pp. 1161–68, doi:<a href=\"https://doi.org/10.1126/science.adq6434\">10.1126/science.adq6434</a>.","ama":"Yao Y, Wilborn AM, Lemaire B, et al. Programming liquid crystal elastomers for multistep ambidirectional deformability. <i>Science</i>. 2024;386(6726):1161-1168. doi:<a href=\"https://doi.org/10.1126/science.adq6434\">10.1126/science.adq6434</a>","chicago":"Yao, Yuxing, Atalaya Milan Wilborn, Baptiste Lemaire, Foteini Trigka, Friedrich J Stricker, Alan H. Weible, Shucong Li, et al. “Programming Liquid Crystal Elastomers for Multistep Ambidirectional Deformability.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adq6434\">https://doi.org/10.1126/science.adq6434</a>.","ieee":"Y. Yao <i>et al.</i>, “Programming liquid crystal elastomers for multistep ambidirectional deformability,” <i>Science</i>, vol. 386, no. 6726. American Association for the Advancement of Science, pp. 1161–1168, 2024.","short":"Y. Yao, A.M. Wilborn, B. Lemaire, F. Trigka, F.J. Stricker, A.H. Weible, S. Li, R.K.A. Bennett, T.C. Cheung, A. Grinthal, M. Zhernenkov, G. Freychet, P. Wąsik, B. Kozinsky, M.M. Lerch, X. Wang, J. Aizenberg, Science 386 (2024) 1161–1168.","apa":"Yao, Y., Wilborn, A. M., Lemaire, B., Trigka, F., Stricker, F. J., Weible, A. H., … Aizenberg, J. (2024). Programming liquid crystal elastomers for multistep ambidirectional deformability. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adq6434\">https://doi.org/10.1126/science.adq6434</a>","ista":"Yao Y, Wilborn AM, Lemaire B, Trigka F, Stricker FJ, Weible AH, Li S, Bennett RKA, Cheung TC, Grinthal A, Zhernenkov M, Freychet G, Wąsik P, Kozinsky B, Lerch MM, Wang X, Aizenberg J. 2024. Programming liquid crystal elastomers for multistep ambidirectional deformability. Science. 386(6726), 1161–1168."},"date_published":"2024-12-06T00:00:00Z","doi":"10.1126/science.adq6434","date_created":"2026-05-06T10:54:51Z","status":"public","day":"06","type":"journal_article","issue":"6726","title":"Programming liquid crystal elastomers for multistep ambidirectional deformability","OA_type":"closed access","scopus_import":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"ddc":["540"],"extern":"1","abstract":[{"text":"Ambidirectionality, which is the ability of structural elements to move beyond a reference state in two opposite directions, is common in nature. However, conventional soft materials are typically limited to a single, unidirectional deformation unless complex hybrid constructs are used. We exploited the combination of mesogen self-assembly, polymer chain elasticity, and polymerization-induced stress to design liquid crystalline elastomers that exhibit two mesophases: chevron smectic C (cSmC) and smectic A (SmA). Inducing the cSmC-SmA–isotropic phase transition led to an unusual inversion of the strain field in the microstructure, resulting in opposite deformation modes (e.g., consecutive shrinkage or expansion and right-handed or left-handed twisting and tilting in opposite directions) and high-frequency nonmonotonic oscillations. This ambidirectional movement is scalable and can be used to generate Gaussian transformations at the macroscale.","lang":"eng"}],"external_id":{"pmid":["39636998"]},"author":[{"full_name":"Yao, Yuxing","first_name":"Yuxing","last_name":"Yao"},{"first_name":"Atalaya Milan","last_name":"Wilborn","full_name":"Wilborn, Atalaya Milan"},{"first_name":"Baptiste","last_name":"Lemaire","full_name":"Lemaire, Baptiste"},{"full_name":"Trigka, Foteini","last_name":"Trigka","first_name":"Foteini"},{"id":"7aca2cfc-46cf-11f0-abd3-8c96b5186745","full_name":"Stricker, Friedrich J","last_name":"Stricker","first_name":"Friedrich J"},{"first_name":"Alan H.","last_name":"Weible","full_name":"Weible, Alan H."},{"full_name":"Li, Shucong","first_name":"Shucong","last_name":"Li"},{"full_name":"Bennett, Robert K. A.","last_name":"Bennett","first_name":"Robert K. A."},{"last_name":"Cheung","first_name":"Tung Chun","full_name":"Cheung, Tung Chun"},{"full_name":"Grinthal, Alison","first_name":"Alison","last_name":"Grinthal"},{"first_name":"Mikhail","last_name":"Zhernenkov","full_name":"Zhernenkov, Mikhail"},{"last_name":"Freychet","first_name":"Guillaume","full_name":"Freychet, Guillaume"},{"last_name":"Wąsik","first_name":"Patryk","full_name":"Wąsik, Patryk"},{"full_name":"Kozinsky, Boris","first_name":"Boris","last_name":"Kozinsky"},{"full_name":"Lerch, Michael M.","first_name":"Michael M.","last_name":"Lerch"},{"full_name":"Wang, Xiaoguang","last_name":"Wang","first_name":"Xiaoguang"},{"first_name":"Joanna","last_name":"Aizenberg","full_name":"Aizenberg, Joanna"}],"oa_version":"None","_id":"21817","page":"1161-1168","article_type":"original","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","publication_status":"published","volume":386,"year":"2024","date_updated":"2026-05-12T09:48:12Z"},{"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","isi":1,"year":"2024","volume":383,"publication_status":"published","date_updated":"2025-09-04T13:12:19Z","external_id":{"isi":["001273082800019"],"pmid":["38484066"]},"author":[{"orcid":"0000-0001-7408-8197","full_name":"Navita, Navita","id":"6ebe278d-ba0b-11ee-8184-f34cdc671de4","first_name":"Navita","last_name":"Navita"},{"last_name":"Ibáñez","first_name":"Maria","id":"43C61214-F248-11E8-B48F-1D18A9856A87","full_name":"Ibáñez, Maria","orcid":"0000-0001-5013-2843"}],"abstract":[{"text":"Reducing defects boosts room-temperature performance of a thermoelectric device","lang":"eng"}],"department":[{"_id":"MaIb"}],"_id":"15166","project":[{"name":"HighTE: The Werner Siemens Laboratory for the High Throughput Discovery of Semiconductors for Waste Heat Recovery","_id":"9B8F7476-BA93-11EA-9121-9846C619BF3A"}],"oa_version":"None","page":"1184","article_type":"letter_note","status":"public","doi":"10.1126/science.ado4077","date_created":"2024-03-24T23:00:58Z","acknowledgement":"The authors thank the Werner-Siemens-Stiftung and the Institute of Science and Technology Austria for financial support.","day":"14","type":"journal_article","issue":"6688","title":"Electron highways are cooler","scopus_import":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"corr_author":"1","publication":"Science","quality_controlled":"1","article_processing_charge":"No","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"month":"03","pmid":1,"intvolume":"       383","citation":{"apa":"Jakhar, N., &#38; Ibáñez, M. (2024). Electron highways are cooler. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.ado4077\">https://doi.org/10.1126/science.ado4077</a>","ista":"Jakhar N, Ibáñez M. 2024. Electron highways are cooler. Science. 383(6688), 1184.","short":"N. Jakhar, M. Ibáñez, Science 383 (2024) 1184.","ama":"Jakhar N, Ibáñez M. Electron highways are cooler. <i>Science</i>. 2024;383(6688):1184. doi:<a href=\"https://doi.org/10.1126/science.ado4077\">10.1126/science.ado4077</a>","ieee":"N. Jakhar and M. Ibáñez, “Electron highways are cooler,” <i>Science</i>, vol. 383, no. 6688. American Association for the Advancement of Science, p. 1184, 2024.","chicago":"Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.ado4077\">https://doi.org/10.1126/science.ado4077</a>.","mla":"Jakhar, Navita, and Maria Ibáñez. “Electron Highways Are Cooler.” <i>Science</i>, vol. 383, no. 6688, American Association for the Advancement of Science, 2024, p. 1184, doi:<a href=\"https://doi.org/10.1126/science.ado4077\">10.1126/science.ado4077</a>."},"date_published":"2024-03-14T00:00:00Z"},{"date_published":"2024-04-04T00:00:00Z","citation":{"ama":"Zocher S, Mccloskey A, Karasinsky A, et al. Lifelong persistence of nuclear RNAs in the mouse brain. <i>Science</i>. 2024;384(6691):53-59. doi:<a href=\"https://doi.org/10.1126/science.adf3481\">10.1126/science.adf3481</a>","chicago":"Zocher, Sara, Asako Mccloskey, Anne Karasinsky, Roberta Schulte, Ulrike Friedrich, Mathias Lesche, Nicole Rund, Fred H. Gage, Martin Hetzer, and Tomohisa Toda. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adf3481\">https://doi.org/10.1126/science.adf3481</a>.","ieee":"S. Zocher <i>et al.</i>, “Lifelong persistence of nuclear RNAs in the mouse brain,” <i>Science</i>, vol. 384, no. 6691. AAAS, pp. 53–59, 2024.","mla":"Zocher, Sara, et al. “Lifelong Persistence of Nuclear RNAs in the Mouse Brain.” <i>Science</i>, vol. 384, no. 6691, AAAS, 2024, pp. 53–59, doi:<a href=\"https://doi.org/10.1126/science.adf3481\">10.1126/science.adf3481</a>.","ista":"Zocher S, Mccloskey A, Karasinsky A, Schulte R, Friedrich U, Lesche M, Rund N, Gage FH, Hetzer M, Toda T. 2024. Lifelong persistence of nuclear RNAs in the mouse brain. Science. 384(6691), 53–59.","apa":"Zocher, S., Mccloskey, A., Karasinsky, A., Schulte, R., Friedrich, U., Lesche, M., … Toda, T. (2024). Lifelong persistence of nuclear RNAs in the mouse brain. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adf3481\">https://doi.org/10.1126/science.adf3481</a>","short":"S. Zocher, A. Mccloskey, A. Karasinsky, R. Schulte, U. Friedrich, M. Lesche, N. Rund, F.H. Gage, M. Hetzer, T. Toda, Science 384 (2024) 53–59."},"intvolume":"       384","month":"04","pmid":1,"language":[{"iso":"eng"}],"OA_place":"repository","publisher":"AAAS","article_processing_charge":"No","quality_controlled":"1","publication":"Science","corr_author":"1","scopus_import":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"OA_type":"green","issue":"6691","title":"Lifelong persistence of nuclear RNAs in the mouse brain","day":"04","type":"journal_article","acknowledgement":"European Research Council: ERC-2018-STG, 804468 EAGER; European Research Council: ERC-2023-COG, 101125034 NEUTIME; Deutsche Forschungsgemeinschaft: TO1347/4-1; Boehringer Ingelheim Stiftung; Deutsches Zentrum für Neurodegenerative Erkrankungen","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7615865"}],"doi":"10.1126/science.adf3481","date_created":"2024-04-14T22:01:01Z","status":"public","oa":1,"article_type":"original","page":"53-59","oa_version":"Submitted Version","_id":"15316","department":[{"_id":"MaHe"}],"abstract":[{"text":"Genomic DNA that resides in the nuclei of mammalian neurons can be as old as the organism itself. The life span of nuclear RNAs, which are critical for proper chromatin architecture and transcription regulation, has not been determined in adult tissues. In this work, we identified and characterized nuclear RNAs that do not turn over for at least 2 years in a subset of postnatally born cells in the mouse brain. These long-lived RNAs were stably retained in nuclei in a neural cell type–specific manner and were required for the maintenance of heterochromatin. Thus, the life span of neural cells may depend on both the molecular longevity of DNA for the storage of genetic information and also the extreme stability of RNA for the functional organization of chromatin.","lang":"eng"}],"author":[{"last_name":"Zocher","first_name":"Sara","full_name":"Zocher, Sara"},{"first_name":"Asako","last_name":"Mccloskey","full_name":"Mccloskey, Asako"},{"last_name":"Karasinsky","first_name":"Anne","full_name":"Karasinsky, Anne"},{"full_name":"Schulte, Roberta","last_name":"Schulte","first_name":"Roberta"},{"full_name":"Friedrich, Ulrike","last_name":"Friedrich","first_name":"Ulrike"},{"full_name":"Lesche, Mathias","first_name":"Mathias","last_name":"Lesche"},{"last_name":"Rund","first_name":"Nicole","full_name":"Rund, Nicole"},{"last_name":"Gage","first_name":"Fred H.","full_name":"Gage, Fred H."},{"orcid":"0000-0002-2111-992X","full_name":"Hetzer, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"Hetzer"},{"last_name":"Toda","first_name":"Tomohisa","full_name":"Toda, Tomohisa"}],"external_id":{"isi":["001253335100031"],"pmid":["38574132"]},"date_updated":"2025-09-04T13:39:58Z","publication_status":"published","year":"2024","volume":384,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","isi":1,"related_material":{"link":[{"url":"https://ista.ac.at/en/news/nerve-cells-old-at-heart/","relation":"press_release","description":"News on ISTA website"}]}},{"isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","volume":384,"year":"2024","publication_status":"published","date_updated":"2025-09-08T07:43:13Z","external_id":{"pmid":["38781391"],"isi":["001230029500001"]},"author":[{"full_name":"Heintz, Kasper E.","first_name":"Kasper E.","last_name":"Heintz"},{"full_name":"Watson, Darach","last_name":"Watson","first_name":"Darach"},{"full_name":"Brammer, Gabriel","last_name":"Brammer","first_name":"Gabriel"},{"last_name":"Vejlgaard","first_name":"Simone","full_name":"Vejlgaard, Simone"},{"first_name":"Anne","last_name":"Hutter","full_name":"Hutter, Anne"},{"full_name":"Strait, Victoria B.","first_name":"Victoria B.","last_name":"Strait"},{"id":"7439a258-f3c0-11ec-9501-9df22fe06720","full_name":"Matthee, Jorryt J","orcid":"0000-0003-2871-127X","last_name":"Matthee","first_name":"Jorryt J"},{"first_name":"Pascal A.","last_name":"Oesch","full_name":"Oesch, Pascal A."},{"last_name":"Jakobsson","first_name":"Páll","full_name":"Jakobsson, Páll"},{"full_name":"Tanvir, Nial R.","last_name":"Tanvir","first_name":"Nial R."},{"full_name":"Laursen, Peter","last_name":"Laursen","first_name":"Peter"},{"full_name":"Naidu, Rohan P.","first_name":"Rohan P.","last_name":"Naidu"},{"full_name":"Mason, Charlotte A.","last_name":"Mason","first_name":"Charlotte A."},{"full_name":"Killi, Meghana","last_name":"Killi","first_name":"Meghana"},{"first_name":"Intae","last_name":"Jung","full_name":"Jung, Intae"},{"last_name":"Hsiao","first_name":"Tiger Yu Yang","full_name":"Hsiao, Tiger Yu Yang"},{"full_name":"Abdurro’Uf, Unknown","first_name":"Unknown","last_name":"Abdurro’Uf"},{"full_name":"Coe, Dan","last_name":"Coe","first_name":"Dan"},{"first_name":"Pablo Arrabal","last_name":"Haro","full_name":"Haro, Pablo Arrabal"},{"full_name":"Finkelstein, Steven L.","first_name":"Steven L.","last_name":"Finkelstein"},{"full_name":"Toft, Sune","first_name":"Sune","last_name":"Toft"}],"abstract":[{"text":"Primordial neutral atomic gas, mostly composed of hydrogen, is the raw material for star formation in galaxies. However, there are few direct constraints on the amount of neutral atomic hydrogen (H i) in galaxies at early cosmic times. We analyzed James Webb Space Telescope (JWST) near-infrared spectroscopy of distant galaxies, at redshifts ≳8. From a sample of 12 galaxies, we identified three that show strong damped Lyman-α absorption due to H i in their local surroundings. The galaxies are located at spectroscopic redshifts of 8.8, 10.2, and 11.4, corresponding to 400 to 600 million years after the Big Bang. They have H i column densities ≳1022 cm−2, which is an order of magnitude higher than expected for a fully neutral intergalactic medium, and constitute a gas-rich population of young star-forming galaxies.","lang":"eng"}],"department":[{"_id":"JoMa"}],"_id":"17090","oa_version":"Submitted Version","article_type":"original","page":"890-894","oa":1,"status":"public","main_file_link":[{"url":"https://figshare.com/articles/journal_contribution/Strong_damped_Lyman-_absorption_in_young_star-forming_galaxies_at_redshifts_9_to_11/26069122?file=47174584","open_access":"1"}],"doi":"10.1126/science.adj0343","date_created":"2024-06-02T22:00:56Z","acknowledgement":"K.E.H. acknowledges support from Carlsberg Foundation Reintegration Fellowship grant CF21-0103. A.H. acknowledges support from the VILLUM FONDEN under grant 37459. C.A.M. acknowledges support from the VILLUM FONDEN under grant 37459 and the Carlsberg Foundation under grant CF22-1322. N.R.T. was funded through Science and Technology Facilities Council (STFC) consolidated grant ST/W000857/1. R.P.N. acknowledges funding from JWST programs GO-1933 and GO-2279. R.P.N. was supported by the NASA Hubble Fellowship grant HST-HF2-51515.001-A awarded by the Space Telescope Science Institute, which is operated by the Association of Universities for Research in Astronomy under NASA contract NAS5-26555. P.A.O. received funding from the Swiss State Secretariat for Education, Research, and Innovation (SERI) under contract number MB22.00072 and from the Swiss National Science Foundation (SNSF) through project grant 200020_207349.","type":"journal_article","day":"24","issue":"6698","title":"Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11","OA_type":"green","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"scopus_import":"1","publication":"Science","quality_controlled":"1","article_processing_charge":"No","publisher":"AAAS","OA_place":"repository","language":[{"iso":"eng"}],"pmid":1,"month":"05","intvolume":"       384","citation":{"short":"K.E. Heintz, D. Watson, G. Brammer, S. Vejlgaard, A. Hutter, V.B. Strait, J.J. Matthee, P.A. Oesch, P. Jakobsson, N.R. Tanvir, P. Laursen, R.P. Naidu, C.A. Mason, M. Killi, I. Jung, T.Y.Y. Hsiao, U. Abdurro’Uf, D. Coe, P.A. Haro, S.L. Finkelstein, S. Toft, Science 384 (2024) 890–894.","apa":"Heintz, K. E., Watson, D., Brammer, G., Vejlgaard, S., Hutter, A., Strait, V. B., … Toft, S. (2024). Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adj0343\">https://doi.org/10.1126/science.adj0343</a>","ista":"Heintz KE, Watson D, Brammer G, Vejlgaard S, Hutter A, Strait VB, Matthee JJ, Oesch PA, Jakobsson P, Tanvir NR, Laursen P, Naidu RP, Mason CA, Killi M, Jung I, Hsiao TYY, Abdurro’Uf U, Coe D, Haro PA, Finkelstein SL, Toft S. 2024. Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11. Science. 384(6698), 890–894.","mla":"Heintz, Kasper E., et al. “Strong Damped Lyman-a Absorption in Young Star-Forming Galaxies at Redshifts 9 to 11.” <i>Science</i>, vol. 384, no. 6698, AAAS, 2024, pp. 890–94, doi:<a href=\"https://doi.org/10.1126/science.adj0343\">10.1126/science.adj0343</a>.","chicago":"Heintz, Kasper E., Darach Watson, Gabriel Brammer, Simone Vejlgaard, Anne Hutter, Victoria B. Strait, Jorryt J Matthee, et al. “Strong Damped Lyman-a Absorption in Young Star-Forming Galaxies at Redshifts 9 to 11.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adj0343\">https://doi.org/10.1126/science.adj0343</a>.","ieee":"K. E. Heintz <i>et al.</i>, “Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11,” <i>Science</i>, vol. 384, no. 6698. AAAS, pp. 890–894, 2024.","ama":"Heintz KE, Watson D, Brammer G, et al. Strong damped Lyman-a absorption in young star-forming galaxies at redshifts 9 to 11. <i>Science</i>. 2024;384(6698):890-894. doi:<a href=\"https://doi.org/10.1126/science.adj0343\">10.1126/science.adj0343</a>"},"date_published":"2024-05-24T00:00:00Z"},{"type":"journal_article","day":"24","doi":"10.1126/science.adp4663","date_created":"2024-06-02T22:00:57Z","status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"scopus_import":"1","corr_author":"1","title":"Mapping the brain’s gene-regulatory maze","issue":"6698","month":"05","pmid":1,"publisher":"AAAS","language":[{"iso":"eng"}],"quality_controlled":"1","article_processing_charge":"No","publication":"Science","citation":{"mla":"Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory Maze.” <i>Science</i>, vol. 384, no. 6698, AAAS, 2024, pp. 860–61, doi:<a href=\"https://doi.org/10.1126/science.adp4663\">10.1126/science.adp4663</a>.","ieee":"G. Novarino and C. Bock, “Mapping the brain’s gene-regulatory maze,” <i>Science</i>, vol. 384, no. 6698. AAAS, pp. 860–861, 2024.","chicago":"Novarino, Gaia, and Christoph Bock. “Mapping the Brain’s Gene-Regulatory Maze.” <i>Science</i>. AAAS, 2024. <a href=\"https://doi.org/10.1126/science.adp4663\">https://doi.org/10.1126/science.adp4663</a>.","ama":"Novarino G, Bock C. Mapping the brain’s gene-regulatory maze. <i>Science</i>. 2024;384(6698):860-861. doi:<a href=\"https://doi.org/10.1126/science.adp4663\">10.1126/science.adp4663</a>","short":"G. Novarino, C. Bock, Science 384 (2024) 860–861.","ista":"Novarino G, Bock C. 2024. Mapping the brain’s gene-regulatory maze. Science. 384(6698), 860–861.","apa":"Novarino, G., &#38; Bock, C. (2024). Mapping the brain’s gene-regulatory maze. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.adp4663\">https://doi.org/10.1126/science.adp4663</a>"},"date_published":"2024-05-24T00:00:00Z","intvolume":"       384","publication_status":"published","year":"2024","volume":384,"isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","date_updated":"2025-09-08T07:40:10Z","department":[{"_id":"GaNo"}],"abstract":[{"text":"DNA sequences are connected to genes and functions in the developing and adult brain","lang":"eng"}],"external_id":{"isi":["001230076500007"],"pmid":["38781359"]},"author":[{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","full_name":"Novarino, Gaia","last_name":"Novarino","first_name":"Gaia"},{"first_name":"Christoph","last_name":"Bock","full_name":"Bock, Christoph"}],"article_type":"letter_note","page":"860-861","oa_version":"None","_id":"17091"},{"publication_status":"published","year":"2024","volume":383,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-09-24T08:31:45Z","extern":"1","abstract":[{"lang":"eng","text":"The generation of cyclic oligoadenylates and subsequent allosteric activation of proteins that carry sensory domains is a distinctive feature of type III CRISPR-Cas systems. In this work, we characterize a set of associated genes of a type III-B system from Haliangium ochraceum that contains two caspase-like proteases, SAVED-CHAT and PCaspase (prokaryotic caspase), co-opted from a cyclic oligonucleotide–based antiphage signaling system (CBASS). Cyclic tri–adenosine monophosphate (AMP)–induced oligomerization of SAVED-CHAT activates proteolytic activity of the CHAT domains, which specifically cleave and activate PCaspase. Subsequently, activated PCaspase cleaves a multitude of proteins, which results in a strong interference phenotype in vivo in Escherichia coli. Taken together, our findings reveal how a CRISPR-Cas–based detection of a target RNA triggers a cascade of caspase-associated proteolytic activities."}],"external_id":{"pmid":["38301007"]},"author":[{"full_name":"Steens, Jurre A.","last_name":"Steens","first_name":"Jurre A."},{"id":"96aecfa5-8931-11ee-af30-aa6a5d6eee0e","orcid":"0000-0003-0456-0753","full_name":"Bravo, Jack Peter Kelly","last_name":"Bravo","first_name":"Jack Peter Kelly"},{"first_name":"Carl Raymund P.","last_name":"Salazar","full_name":"Salazar, Carl Raymund P."},{"full_name":"Yildiz, Caglar","first_name":"Caglar","last_name":"Yildiz"},{"first_name":"Afonso M.","last_name":"Amieiro","full_name":"Amieiro, Afonso M."},{"first_name":"Stephan","last_name":"Köstlbacher","full_name":"Köstlbacher, Stephan"},{"last_name":"Prinsen","first_name":"Stijn H.P.","full_name":"Prinsen, Stijn H.P."},{"last_name":"Patinios","first_name":"Constantinos","full_name":"Patinios, Constantinos"},{"last_name":"Bardis","first_name":"Andreas","full_name":"Bardis, Andreas"},{"full_name":"Barendregt, Arjan","first_name":"Arjan","last_name":"Barendregt"},{"full_name":"Scheltema, Richard A.","first_name":"Richard A.","last_name":"Scheltema"},{"last_name":"Ettema","first_name":"Thijs J.G.","full_name":"Ettema, Thijs J.G."},{"full_name":"van der Oost, John","last_name":"van der Oost","first_name":"John"},{"first_name":"David W.","last_name":"Taylor","full_name":"Taylor, David W."},{"last_name":"Staals","first_name":"Raymond H.J.","full_name":"Staals, Raymond H.J."}],"oa":1,"article_type":"original","page":"512-519","oa_version":"Preprint","_id":"17112","day":"01","type":"journal_article","acknowledgement":"We thank R. Fregoso Ocampo for assistance with negative-stain EM imaging. This work was funded by Dutch Research Council (NWO) VIDI grant VI.Vidi.203.074 (R.H.J.S.), NWO Spinoza grant SPI 93-537 (J.v.d.O.), European Research Council (ERC) Advanced grant ERC-AdG-834279 (J.v.d.O.), ERC CoG grant 817834 (T.J.G.E.), NWO VICI grant VI.C.192.016 (T.J.G.E.), Volkswagen Foundation grant 96725 (T.J.G.E.), National Institute of General Medical Sciences of the National Institutes of Health grant R35GM138348 (D.W.T.), Welch Foundation research grant F-1938 (D.W.T.), a Robert J. Kleberg, Jr. And Helen C. Kleberg Foundation medical research grant (D.W.T.), and American Cancer Society Research Scholar grant RSG-21-050-01-DMC (D.W.T.).","main_file_link":[{"url":"https://doi.org/10.1101/2023.06.23.546230","open_access":"1"}],"doi":"10.1126/science.adk0378","date_created":"2024-06-04T06:41:26Z","status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"scopus_import":"1","issue":"6682","title":"Type III-B CRISPR-Cas cascade of proteolytic cleavages","OA_type":"green","pmid":1,"month":"02","publisher":"American Association for the Advancement of Science","OA_place":"repository","language":[{"iso":"eng"}],"quality_controlled":"1","article_processing_charge":"No","publication":"Science","citation":{"apa":"Steens, J. A., Bravo, J. P. K., Salazar, C. R. P., Yildiz, C., Amieiro, A. M., Köstlbacher, S., … Staals, R. H. J. (2024). Type III-B CRISPR-Cas cascade of proteolytic cleavages. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adk0378\">https://doi.org/10.1126/science.adk0378</a>","ista":"Steens JA, Bravo JPK, Salazar CRP, Yildiz C, Amieiro AM, Köstlbacher S, Prinsen SHP, Patinios C, Bardis A, Barendregt A, Scheltema RA, Ettema TJG, van der Oost J, Taylor DW, Staals RHJ. 2024. Type III-B CRISPR-Cas cascade of proteolytic cleavages. Science. 383(6682), 512–519.","short":"J.A. Steens, J.P.K. Bravo, C.R.P. Salazar, C. Yildiz, A.M. Amieiro, S. Köstlbacher, S.H.P. Prinsen, C. Patinios, A. Bardis, A. Barendregt, R.A. Scheltema, T.J.G. Ettema, J. van der Oost, D.W. Taylor, R.H.J. Staals, Science 383 (2024) 512–519.","ama":"Steens JA, Bravo JPK, Salazar CRP, et al. Type III-B CRISPR-Cas cascade of proteolytic cleavages. <i>Science</i>. 2024;383(6682):512-519. doi:<a href=\"https://doi.org/10.1126/science.adk0378\">10.1126/science.adk0378</a>","ieee":"J. A. Steens <i>et al.</i>, “Type III-B CRISPR-Cas cascade of proteolytic cleavages,” <i>Science</i>, vol. 383, no. 6682. American Association for the Advancement of Science, pp. 512–519, 2024.","chicago":"Steens, Jurre A., Jack Peter Kelly Bravo, Carl Raymund P. Salazar, Caglar Yildiz, Afonso M. Amieiro, Stephan Köstlbacher, Stijn H.P. Prinsen, et al. “Type III-B CRISPR-Cas Cascade of Proteolytic Cleavages.” <i>Science</i>. American Association for the Advancement of Science, 2024. <a href=\"https://doi.org/10.1126/science.adk0378\">https://doi.org/10.1126/science.adk0378</a>.","mla":"Steens, Jurre A., et al. “Type III-B CRISPR-Cas Cascade of Proteolytic Cleavages.” <i>Science</i>, vol. 383, no. 6682, American Association for the Advancement of Science, 2024, pp. 512–19, doi:<a href=\"https://doi.org/10.1126/science.adk0378\">10.1126/science.adk0378</a>."},"date_published":"2024-02-01T00:00:00Z","intvolume":"       383"},{"abstract":[{"lang":"eng","text":"The hydrogen-rich outer layers of massive stars can be removed by interactions with a binary companion. Theoretical models predict that this stripping produces a population of hot helium stars of ~2 to 8 solar masses (M☉), however, only one such system has been identified thus far. We used ultraviolet photometry to identify potential stripped helium stars then investigated 25 of them using optical spectroscopy. We identified stars with high temperatures (~60,000 to 100,000 kelvin), high surface gravities, and hydrogen-depleted surfaces; 16 stars also showed binary motion. These properties match expectations for stars with initial masses of 8 to 25 M☉ that were stripped by binary interaction. Their masses fall in the gap between subdwarf helium stars and Wolf-Rayet stars. We propose that these stars could be progenitors of stripped-envelope supernovae."}],"extern":"1","external_id":{"arxiv":["2307.00061"],"pmid":["38096420"]},"author":[{"full_name":"Drout, M. R.","first_name":"M. R.","last_name":"Drout"},{"id":"d0648d0c-0f64-11ee-a2e0-dd0faa2e4f7d","full_name":"Götberg, Ylva Louise Linsdotter","orcid":"0000-0002-6960-6911","last_name":"Götberg","first_name":"Ylva Louise Linsdotter"},{"first_name":"B. A.","last_name":"Ludwig","full_name":"Ludwig, B. A."},{"full_name":"Groh, J. H.","first_name":"J. H.","last_name":"Groh"},{"full_name":"de Mink, S. E.","last_name":"de Mink","first_name":"S. E."},{"full_name":"O’Grady, A. J. G.","last_name":"O’Grady","first_name":"A. J. G."},{"first_name":"N.","last_name":"Smith","full_name":"Smith, N."}],"oa_version":"None","_id":"15085","oa":1,"page":"1287-1291","article_type":"original","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"link":[{"relation":"press_release","description":"News on ISTA Website","url":"https://ista.ac.at/en/news/reaching-for-the-invisible-stars/"}]},"publication_status":"published","volume":382,"year":"2023","keyword":["Stellar Astrophysics"],"date_updated":"2024-10-14T12:32:01Z","quality_controlled":"1","article_processing_charge":"No","publication":"Science","pmid":1,"month":"12","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"intvolume":"       382","citation":{"ista":"Drout MR, Götberg YLL, Ludwig BA, Groh JH, de Mink SE, O’Grady AJG, Smith N. 2023. An observed population of intermediate-mass helium stars that have been stripped in binaries. Science. 382(6676), 1287–1291.","apa":"Drout, M. R., Götberg, Y. L. L., Ludwig, B. A., Groh, J. H., de Mink, S. E., O’Grady, A. J. G., &#38; Smith, N. (2023). An observed population of intermediate-mass helium stars that have been stripped in binaries. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.ade4970\">https://doi.org/10.1126/science.ade4970</a>","short":"M.R. Drout, Y.L.L. Götberg, B.A. Ludwig, J.H. Groh, S.E. de Mink, A.J.G. O’Grady, N. Smith, Science 382 (2023) 1287–1291.","ieee":"M. R. Drout <i>et al.</i>, “An observed population of intermediate-mass helium stars that have been stripped in binaries,” <i>Science</i>, vol. 382, no. 6676. American Association for the Advancement of Science, pp. 1287–1291, 2023.","chicago":"Drout, M. R., Ylva Louise Linsdotter Götberg, B. A. Ludwig, J. H. Groh, S. E. de Mink, A. J. G. O’Grady, and N. Smith. “An Observed Population of Intermediate-Mass Helium Stars That Have Been Stripped in Binaries.” <i>Science</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.ade4970\">https://doi.org/10.1126/science.ade4970</a>.","ama":"Drout MR, Götberg YLL, Ludwig BA, et al. An observed population of intermediate-mass helium stars that have been stripped in binaries. <i>Science</i>. 2023;382(6676):1287-1291. doi:<a href=\"https://doi.org/10.1126/science.ade4970\">10.1126/science.ade4970</a>","mla":"Drout, M. R., et al. “An Observed Population of Intermediate-Mass Helium Stars That Have Been Stripped in Binaries.” <i>Science</i>, vol. 382, no. 6676, American Association for the Advancement of Science, 2023, pp. 1287–91, doi:<a href=\"https://doi.org/10.1126/science.ade4970\">10.1126/science.ade4970</a>."},"date_published":"2023-12-14T00:00:00Z","date_created":"2024-03-05T09:40:28Z","doi":"10.1126/science.ade4970","arxiv":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2307.00061"}],"status":"public","day":"14","type":"journal_article","issue":"6676","title":"An observed population of intermediate-mass helium stars that have been stripped in binaries","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"scopus_import":"1"},{"volume":380,"year":"2023","publication_status":"published","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","date_updated":"2026-04-27T08:47:22Z","author":[{"first_name":"Charles","last_name":"Roques-Carmes","full_name":"Roques-Carmes, Charles","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82"}],"abstract":[{"lang":"eng","text":"Efficient learning algorithms are implemented in a silicon photonic neural network chip"}],"extern":"1","article_type":"original","page":"341-342","_id":"21585","oa_version":"None","day":"28","type":"journal_article","status":"public","date_created":"2026-03-30T12:22:48Z","doi":"10.1126/science.adh0724","ddc":["530"],"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"scopus_import":"1","OA_type":"closed access","title":"Learning photons go backward","issue":"6643","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","month":"04","publication":"Science","article_processing_charge":"No","quality_controlled":"1","date_published":"2023-04-28T00:00:00Z","citation":{"apa":"Roques-Carmes, C. (2023). Learning photons go backward. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adh0724\">https://doi.org/10.1126/science.adh0724</a>","ista":"Roques-Carmes C. 2023. Learning photons go backward. Science. 380(6643), 341–342.","short":"C. Roques-Carmes, Science 380 (2023) 341–342.","chicago":"Roques-Carmes, Charles. “Learning Photons Go Backward.” <i>Science</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adh0724\">https://doi.org/10.1126/science.adh0724</a>.","ieee":"C. Roques-Carmes, “Learning photons go backward,” <i>Science</i>, vol. 380, no. 6643. American Association for the Advancement of Science, pp. 341–342, 2023.","ama":"Roques-Carmes C. Learning photons go backward. <i>Science</i>. 2023;380(6643):341-342. doi:<a href=\"https://doi.org/10.1126/science.adh0724\">10.1126/science.adh0724</a>","mla":"Roques-Carmes, Charles. “Learning Photons Go Backward.” <i>Science</i>, vol. 380, no. 6643, American Association for the Advancement of Science, 2023, pp. 341–42, doi:<a href=\"https://doi.org/10.1126/science.adh0724\">10.1126/science.adh0724</a>."},"intvolume":"       380"},{"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","year":"2023","volume":381,"publication_status":"published","date_updated":"2026-04-27T09:16:52Z","external_id":{"pmid":["37440648"],"arxiv":["2303.03455"]},"author":[{"first_name":"Charles","last_name":"Roques-Carmes","full_name":"Roques-Carmes, Charles","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82"},{"full_name":"Salamin, Yannick","last_name":"Salamin","first_name":"Yannick"},{"first_name":"Jamison","last_name":"Sloan","full_name":"Sloan, Jamison"},{"first_name":"Seou","last_name":"Choi","full_name":"Choi, Seou"},{"full_name":"Velez, Gustavo","last_name":"Velez","first_name":"Gustavo"},{"last_name":"Koskas","first_name":"Ethan","full_name":"Koskas, Ethan"},{"full_name":"Rivera, Nicholas","first_name":"Nicholas","last_name":"Rivera"},{"full_name":"Kooi, Steven E.","first_name":"Steven E.","last_name":"Kooi"},{"full_name":"Joannopoulos, John D.","last_name":"Joannopoulos","first_name":"John D."},{"last_name":"Soljačić","first_name":"Marin","full_name":"Soljačić, Marin"}],"abstract":[{"text":"Quantum field theory suggests that electromagnetic fields naturally fluctuate, and these fluctuations can be harnessed as a source of perfect randomness. Many potential applications of randomness rely on controllable probability distributions. We show that vacuum-level bias fields injected into multistable optical systems enable a controllable source of quantum randomness, and we demonstrated this concept in an optical parametric oscillator (OPO). By injecting bias pulses with less than one photon on average, we controlled the probabilities of the two possible OPO output states. The potential of our approach for sensing sub–photon-level fields was demonstrated by reconstructing the temporal shape of fields below the single-photon level. Our results provide a platform to study quantum dynamics in nonlinear driven-dissipative systems and point toward applications in probabilistic computing and weak field sensing.","lang":"eng"}],"extern":"1","_id":"21586","oa_version":"Preprint","page":"205-209","article_type":"original","oa":1,"status":"public","date_created":"2026-03-30T12:22:48Z","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2303.03455","open_access":"1"}],"arxiv":1,"doi":"10.1126/science.adh4920","type":"journal_article","day":"14","title":"Biasing the quantum vacuum to control macroscopic probability distributions","issue":"6654","OA_type":"green","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"scopus_import":"1","ddc":["530"],"publication":"Science","quality_controlled":"1","article_processing_charge":"No","publisher":"American Association for the Advancement of Science","OA_place":"repository","language":[{"iso":"eng"}],"pmid":1,"month":"07","intvolume":"       381","citation":{"apa":"Roques-Carmes, C., Salamin, Y., Sloan, J., Choi, S., Velez, G., Koskas, E., … Soljačić, M. (2023). Biasing the quantum vacuum to control macroscopic probability distributions. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adh4920\">https://doi.org/10.1126/science.adh4920</a>","ista":"Roques-Carmes C, Salamin Y, Sloan J, Choi S, Velez G, Koskas E, Rivera N, Kooi SE, Joannopoulos JD, Soljačić M. 2023. Biasing the quantum vacuum to control macroscopic probability distributions. Science. 381(6654), 205–209.","short":"C. Roques-Carmes, Y. Salamin, J. Sloan, S. Choi, G. Velez, E. Koskas, N. Rivera, S.E. Kooi, J.D. Joannopoulos, M. Soljačić, Science 381 (2023) 205–209.","chicago":"Roques-Carmes, Charles, Yannick Salamin, Jamison Sloan, Seou Choi, Gustavo Velez, Ethan Koskas, Nicholas Rivera, Steven E. Kooi, John D. Joannopoulos, and Marin Soljačić. “Biasing the Quantum Vacuum to Control Macroscopic Probability Distributions.” <i>Science</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adh4920\">https://doi.org/10.1126/science.adh4920</a>.","ieee":"C. Roques-Carmes <i>et al.</i>, “Biasing the quantum vacuum to control macroscopic probability distributions,” <i>Science</i>, vol. 381, no. 6654. American Association for the Advancement of Science, pp. 205–209, 2023.","ama":"Roques-Carmes C, Salamin Y, Sloan J, et al. Biasing the quantum vacuum to control macroscopic probability distributions. <i>Science</i>. 2023;381(6654):205-209. doi:<a href=\"https://doi.org/10.1126/science.adh4920\">10.1126/science.adh4920</a>","mla":"Roques-Carmes, Charles, et al. “Biasing the Quantum Vacuum to Control Macroscopic Probability Distributions.” <i>Science</i>, vol. 381, no. 6654, American Association for the Advancement of Science, 2023, pp. 205–09, doi:<a href=\"https://doi.org/10.1126/science.adh4920\">10.1126/science.adh4920</a>."},"date_published":"2023-07-14T00:00:00Z"},{"publication_status":"published","year":"2023","volume":380,"isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","related_material":{"record":[{"id":"13122","relation":"research_data","status":"public"}],"link":[{"description":"News on ISTA Website","relation":"press_release","url":"https://ista.ac.at/en/news/wiring-up-quantum-circuits-with-light/"}]},"keyword":["Multidisciplinary"],"date_updated":"2026-04-15T06:39:33Z","department":[{"_id":"JoFi"}],"abstract":[{"text":"Quantum entanglement is a key resource in currently developed quantum technologies. Sharing this fragile property between superconducting microwave circuits and optical or atomic systems would enable new functionalities, but this has been hindered by an energy scale mismatch of >104 and the resulting mutually imposed loss and noise. In this work, we created and verified entanglement between microwave and optical fields in a millikelvin environment. Using an optically pulsed superconducting electro-optical device, we show entanglement between propagating microwave and optical fields in the continuous variable domain. This achievement not only paves the way for entanglement between superconducting circuits and telecom wavelength light, but also has wide-ranging implications for hybrid quantum networks in the context of modularization, scaling, sensing, and cross-platform verification.","lang":"eng"}],"external_id":{"pmid":["37200415"],"arxiv":["2301.03315"],"isi":["000996515200004"]},"author":[{"first_name":"Rishabh","last_name":"Sahu","full_name":"Sahu, Rishabh","orcid":"0000-0001-6264-2162","id":"47D26E34-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Liu","last_name":"Qiu","full_name":"Qiu, Liu","orcid":"0000-0003-4345-4267","id":"45e99c0d-1eb1-11eb-9b96-ed8ab2983cac"},{"first_name":"William J","last_name":"Hease","full_name":"Hease, William J","orcid":"0000-0001-9868-2166","id":"29705398-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Arnold","first_name":"Georg M","id":"3770C838-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1397-7876","full_name":"Arnold, Georg M"},{"full_name":"Minoguchi, Y.","last_name":"Minoguchi","first_name":"Y."},{"full_name":"Rabl, P.","first_name":"P.","last_name":"Rabl"},{"orcid":"0000-0001-8112-028X","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","first_name":"Johannes M","last_name":"Fink"}],"oa":1,"article_type":"original","page":"718-721","oa_version":"Preprint","ec_funded":1,"_id":"13106","project":[{"_id":"26336814-B435-11E9-9278-68D0E5697425","grant_number":"758053","call_identifier":"H2020","name":"A Fiber Optic Transceiver for Superconducting Qubits"},{"name":"Quantum Local Area Networks with Superconducting Qubits","_id":"9B868D20-BA93-11EA-9121-9846C619BF3A","grant_number":"899354","call_identifier":"H2020"},{"call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"},{"grant_number":"862644","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020","name":"Quantum readout techniques and technologies"},{"_id":"2671EB66-B435-11E9-9278-68D0E5697425","name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies"},{"_id":"bdb108fd-d553-11ed-ba76-83dc74a9864f","grant_number":"F07105","name":"QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration of Superconducting Quantum Circuits"}],"day":"18","type":"journal_article","acknowledgement":"This work was supported by the European Research Council (grant no. 758053, ERC StG QUNNECT) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 899354, FETopen SuperQuLAN). L.Q. acknowledges generous support from the ISTFELLOW program. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 Research and Innovation Program (Marie Sklodowska-Curie grant no. 754411). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (grant no. F7105) and the European Union’s Horizon 2020 Research and Innovation Program (grant no. 862644, FETopen QUARTET).","doi":"10.1126/science.adg3812","main_file_link":[{"url":"https://doi.org/10.48550/arXiv.2301.03315","open_access":"1"}],"date_created":"2023-05-31T11:39:24Z","arxiv":1,"status":"public","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"scopus_import":"1","corr_author":"1","issue":"6646","title":"Entangling microwaves with light","month":"05","pmid":1,"publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"quality_controlled":"1","article_processing_charge":"No","publication":"Science","citation":{"ista":"Sahu R, Qiu L, Hease WJ, Arnold GM, Minoguchi Y, Rabl P, Fink JM. 2023. Entangling microwaves with light. Science. 380(6646), 718–721.","apa":"Sahu, R., Qiu, L., Hease, W. J., Arnold, G. M., Minoguchi, Y., Rabl, P., &#38; Fink, J. M. (2023). Entangling microwaves with light. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>","short":"R. Sahu, L. Qiu, W.J. Hease, G.M. Arnold, Y. Minoguchi, P. Rabl, J.M. Fink, Science 380 (2023) 718–721.","chicago":"Sahu, Rishabh, Liu Qiu, William J Hease, Georg M Arnold, Y. Minoguchi, P. Rabl, and Johannes M Fink. “Entangling Microwaves with Light.” <i>Science</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adg3812\">https://doi.org/10.1126/science.adg3812</a>.","ieee":"R. Sahu <i>et al.</i>, “Entangling microwaves with light,” <i>Science</i>, vol. 380, no. 6646. American Association for the Advancement of Science, pp. 718–721, 2023.","ama":"Sahu R, Qiu L, Hease WJ, et al. Entangling microwaves with light. <i>Science</i>. 2023;380(6646):718-721. doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>","mla":"Sahu, Rishabh, et al. “Entangling Microwaves with Light.” <i>Science</i>, vol. 380, no. 6646, American Association for the Advancement of Science, 2023, pp. 718–21, doi:<a href=\"https://doi.org/10.1126/science.adg3812\">10.1126/science.adg3812</a>."},"date_published":"2023-05-18T00:00:00Z","intvolume":"       380"},{"extern":"1","abstract":[{"lang":"eng","text":"In nature, proteins that switch between two conformations in response to environmental stimuli structurally transduce biochemical information in a manner analogous to how transistors control information flow in computing devices. Designing proteins with two distinct but fully structured conformations is a challenge for protein design as it requires sculpting an energy landscape with two distinct minima. Here we describe the design of “hinge” proteins that populate one designed state in the absence of ligand and a second designed state in the presence of ligand. X-ray crystallography, electron microscopy, double electron-electron resonance spectroscopy, and binding measurements demonstrate that despite the significant structural differences the two states are designed with atomic level accuracy and that the conformational and binding equilibria are closely coupled."}],"external_id":{"pmid":["37590357"]},"author":[{"first_name":"Florian M","last_name":"Praetorius","full_name":"Praetorius, Florian M","id":"dfec9381-4341-11ee-8fd8-faa02bba7d62"},{"first_name":"Philip J. Y.","last_name":"Leung","full_name":"Leung, Philip J. Y."},{"last_name":"Tessmer","first_name":"Maxx H.","full_name":"Tessmer, Maxx H."},{"last_name":"Broerman","first_name":"Adam","full_name":"Broerman, Adam"},{"first_name":"Cullen","last_name":"Demakis","full_name":"Demakis, Cullen"},{"full_name":"Dishman, Acacia F.","last_name":"Dishman","first_name":"Acacia F."},{"last_name":"Pillai","first_name":"Arvind","full_name":"Pillai, Arvind"},{"first_name":"Abbas","last_name":"Idris","full_name":"Idris, Abbas"},{"first_name":"David","last_name":"Juergens","full_name":"Juergens, David"},{"full_name":"Dauparas, Justas","last_name":"Dauparas","first_name":"Justas"},{"full_name":"Li, Xinting","last_name":"Li","first_name":"Xinting"},{"full_name":"Levine, Paul M.","last_name":"Levine","first_name":"Paul M."},{"full_name":"Lamb, Mila","last_name":"Lamb","first_name":"Mila"},{"first_name":"Ryanne K.","last_name":"Ballard","full_name":"Ballard, Ryanne K."},{"first_name":"Stacey R.","last_name":"Gerben","full_name":"Gerben, Stacey R."},{"full_name":"Nguyen, Hannah","last_name":"Nguyen","first_name":"Hannah"},{"full_name":"Kang, Alex","last_name":"Kang","first_name":"Alex"},{"full_name":"Sankaran, Banumathi","first_name":"Banumathi","last_name":"Sankaran"},{"last_name":"Bera","first_name":"Asim K.","full_name":"Bera, Asim K."},{"first_name":"Brian F.","last_name":"Volkman","full_name":"Volkman, Brian F."},{"full_name":"Nivala, Jeff","first_name":"Jeff","last_name":"Nivala"},{"full_name":"Stoll, Stefan","last_name":"Stoll","first_name":"Stefan"},{"full_name":"Baker, David","last_name":"Baker","first_name":"David"}],"article_type":"original","page":"754-760","oa_version":"None","_id":"14281","publication_status":"published","year":"2023","volume":381,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2023-11-07T12:42:09Z","month":"08","pmid":1,"publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"quality_controlled":"1","article_processing_charge":"No","publication":"Science","citation":{"ama":"Praetorius FM, Leung PJY, Tessmer MH, et al. Design of stimulus-responsive two-state hinge proteins. <i>Science</i>. 2023;381(6659):754-760. doi:<a href=\"https://doi.org/10.1126/science.adg7731\">10.1126/science.adg7731</a>","ieee":"F. M. Praetorius <i>et al.</i>, “Design of stimulus-responsive two-state hinge proteins,” <i>Science</i>, vol. 381, no. 6659. American Association for the Advancement of Science, pp. 754–760, 2023.","chicago":"Praetorius, Florian M, Philip J. Y. Leung, Maxx H. Tessmer, Adam Broerman, Cullen Demakis, Acacia F. Dishman, Arvind Pillai, et al. “Design of Stimulus-Responsive Two-State Hinge Proteins.” <i>Science</i>. American Association for the Advancement of Science, 2023. <a href=\"https://doi.org/10.1126/science.adg7731\">https://doi.org/10.1126/science.adg7731</a>.","mla":"Praetorius, Florian M., et al. “Design of Stimulus-Responsive Two-State Hinge Proteins.” <i>Science</i>, vol. 381, no. 6659, American Association for the Advancement of Science, 2023, pp. 754–60, doi:<a href=\"https://doi.org/10.1126/science.adg7731\">10.1126/science.adg7731</a>.","apa":"Praetorius, F. M., Leung, P. J. Y., Tessmer, M. H., Broerman, A., Demakis, C., Dishman, A. F., … Baker, D. (2023). Design of stimulus-responsive two-state hinge proteins. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg7731\">https://doi.org/10.1126/science.adg7731</a>","ista":"Praetorius FM, Leung PJY, Tessmer MH, Broerman A, Demakis C, Dishman AF, Pillai A, Idris A, Juergens D, Dauparas J, Li X, Levine PM, Lamb M, Ballard RK, Gerben SR, Nguyen H, Kang A, Sankaran B, Bera AK, Volkman BF, Nivala J, Stoll S, Baker D. 2023. Design of stimulus-responsive two-state hinge proteins. Science. 381(6659), 754–760.","short":"F.M. Praetorius, P.J.Y. Leung, M.H. Tessmer, A. Broerman, C. Demakis, A.F. Dishman, A. Pillai, A. Idris, D. Juergens, J. Dauparas, X. Li, P.M. Levine, M. Lamb, R.K. Ballard, S.R. Gerben, H. Nguyen, A. Kang, B. Sankaran, A.K. Bera, B.F. Volkman, J. Nivala, S. Stoll, D. Baker, Science 381 (2023) 754–760."},"date_published":"2023-08-17T00:00:00Z","intvolume":"       381","day":"17","type":"journal_article","date_created":"2023-09-06T12:04:23Z","doi":"10.1126/science.adg7731","status":"public","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"scopus_import":"1","title":"Design of stimulus-responsive two-state hinge proteins","issue":"6659"},{"quality_controlled":"1","article_processing_charge":"No","publication":"Science","pmid":1,"month":"04","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"tmp":{"short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png"},"intvolume":"       376","citation":{"chicago":"Akhmanova, Maria, Shamsi Emtenani, Daniel Krueger, Attila György, Mariana Pereira Guarda, Mikhail Vlasov, Fedor Vlasov, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.abj0425\">https://doi.org/10.1126/science.abj0425</a>.","ieee":"M. Akhmanova <i>et al.</i>, “Cell division in tissues enables macrophage infiltration,” <i>Science</i>, vol. 376, no. 6591. American Association for the Advancement of Science, pp. 394–396, 2022.","ama":"Akhmanova M, Emtenani S, Krueger D, et al. Cell division in tissues enables macrophage infiltration. <i>Science</i>. 2022;376(6591):394-396. doi:<a href=\"https://doi.org/10.1126/science.abj0425\">10.1126/science.abj0425</a>","mla":"Akhmanova, Maria, et al. “Cell Division in Tissues Enables Macrophage Infiltration.” <i>Science</i>, vol. 376, no. 6591, American Association for the Advancement of Science, 2022, pp. 394–96, doi:<a href=\"https://doi.org/10.1126/science.abj0425\">10.1126/science.abj0425</a>.","ista":"Akhmanova M, Emtenani S, Krueger D, György A, Pereira Guarda M, Vlasov M, Vlasov F, Akopian A, Ratheesh A, De Renzis S, Siekhaus DE. 2022. Cell division in tissues enables macrophage infiltration. Science. 376(6591), 394–396.","apa":"Akhmanova, M., Emtenani, S., Krueger, D., György, A., Pereira Guarda, M., Vlasov, M., … Siekhaus, D. E. (2022). Cell division in tissues enables macrophage infiltration. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abj0425\">https://doi.org/10.1126/science.abj0425</a>","short":"M. Akhmanova, S. Emtenani, D. Krueger, A. György, M. Pereira Guarda, M. Vlasov, F. Vlasov, A. Akopian, A. Ratheesh, S. De Renzis, D.E. Siekhaus, Science 376 (2022) 394–396."},"date_published":"2022-04-22T00:00:00Z","main_file_link":[{"url":"https://doi.org/10.1101/2021.04.19.438995","open_access":"1"}],"doi":"10.1126/science.abj0425","date_created":"2022-02-01T11:23:18Z","status":"public","type":"journal_article","day":"22","acknowledgement":"We thank J. Friml, C. Guet, T. Hurd, M. Fendrych and members of the laboratory for comments on the manuscript; the Bioimaging Facility of IST Austria for excellent support and T. Lecuit, E. Hafen, R. Levayer and A. Martin for fly strains. This work was supported by a grant from the Austrian Science Fund FWF: Lise Meitner Fellowship M2379-B28 to M.A and D.S., and internal funding from IST Austria to D.S. and EMBL to S.D.R.","title":"Cell division in tissues enables macrophage infiltration","issue":"6591","scopus_import":"1","publication_identifier":{"issn":["0036-8075"]},"corr_author":"1","acknowledged_ssus":[{"_id":"Bio"}],"abstract":[{"text":"Cells migrate through crowded microenvironments within tissues during normal development, immune response, and cancer metastasis. Although migration through pores and tracks in the extracellular matrix (ECM) has been well studied, little is known about cellular traversal into confining cell-dense tissues. We find that embryonic tissue invasion by Drosophila macrophages requires division of an epithelial ectodermal cell at the site of entry. Dividing ectodermal cells disassemble ECM attachment formed by integrin-mediated focal adhesions next to mesodermal cells, allowing macrophages to move their nuclei ahead and invade between two immediately adjacent tissues. Invasion efficiency depends on division frequency, but reduction of adhesion strength allows macrophage entry independently of division. This work demonstrates that tissue dynamics can regulate cellular infiltration.","lang":"eng"}],"external_id":{"isi":["000788553700039"],"pmid":["35446632"]},"author":[{"id":"3425EC26-F248-11E8-B48F-1D18A9856A87","full_name":"Akhmanova, Maria","orcid":"0000-0003-1522-3162","last_name":"Akhmanova","first_name":"Maria"},{"first_name":"Shamsi","last_name":"Emtenani","orcid":"0000-0001-6981-6938","full_name":"Emtenani, Shamsi","id":"49D32318-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Krueger, Daniel","last_name":"Krueger","first_name":"Daniel"},{"full_name":"György, Attila","orcid":"0000-0002-1819-198X","id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","first_name":"Attila","last_name":"György"},{"orcid":"0000-0001-8238-480X","full_name":"Pereira Guarda, Mariana","id":"6de81d9d-e2f2-11eb-945a-af8bc2a60b26","first_name":"Mariana","last_name":"Pereira Guarda"},{"last_name":"Vlasov","first_name":"Mikhail","full_name":"Vlasov, Mikhail"},{"first_name":"Fedor","last_name":"Vlasov","full_name":"Vlasov, Fedor"},{"last_name":"Akopian","first_name":"Andrei","full_name":"Akopian, Andrei"},{"first_name":"Aparna","last_name":"Ratheesh","orcid":"0000-0001-7190-0776","full_name":"Ratheesh, Aparna","id":"2F064CFE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Stefano","last_name":"De Renzis","full_name":"De Renzis, Stefano"},{"first_name":"Daria E","last_name":"Siekhaus","full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353","id":"3D224B9E-F248-11E8-B48F-1D18A9856A87"}],"department":[{"_id":"DaSi"}],"oa_version":"Preprint","project":[{"name":"Modeling epithelial tissue mechanics during cell invasion","call_identifier":"FWF","grant_number":"M02379","_id":"264CBBAC-B435-11E9-9278-68D0E5697425"}],"_id":"10713","oa":1,"article_type":"original","page":"394-396","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"publication_status":"published","volume":376,"year":"2022","date_updated":"2025-04-15T07:25:41Z"},{"corr_author":"1","scopus_import":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"title":"A soft active matter that can climb walls","issue":"6607","day":"12","type":"journal_article","status":"public","date_created":"2022-08-28T22:02:00Z","doi":"10.1126/science.adc9202","date_published":"2022-08-12T00:00:00Z","citation":{"short":"J.A. Palacci, Science 377 (2022) 710–711.","ista":"Palacci JA. 2022. A soft active matter that can climb walls. Science. 377(6607), 710–711.","apa":"Palacci, J. A. (2022). A soft active matter that can climb walls. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adc9202\">https://doi.org/10.1126/science.adc9202</a>","mla":"Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” <i>Science</i>, vol. 377, no. 6607, American Association for the Advancement of Science, 2022, pp. 710–11, doi:<a href=\"https://doi.org/10.1126/science.adc9202\">10.1126/science.adc9202</a>.","ama":"Palacci JA. A soft active matter that can climb walls. <i>Science</i>. 2022;377(6607):710-711. doi:<a href=\"https://doi.org/10.1126/science.adc9202\">10.1126/science.adc9202</a>","ieee":"J. A. Palacci, “A soft active matter that can climb walls,” <i>Science</i>, vol. 377, no. 6607. American Association for the Advancement of Science, pp. 710–711, 2022.","chicago":"Palacci, Jérémie A. “A Soft Active Matter That Can Climb Walls.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.adc9202\">https://doi.org/10.1126/science.adc9202</a>."},"intvolume":"       377","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","pmid":1,"month":"08","publication":"Science","article_processing_charge":"No","quality_controlled":"1","date_updated":"2024-10-09T21:03:21Z","year":"2022","volume":377,"publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"letter_note","page":"710-711","_id":"11996","oa_version":"None","department":[{"_id":"JePa"}],"author":[{"full_name":"Palacci, Jérémie A","orcid":"0000-0002-7253-9465","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","first_name":"Jérémie A","last_name":"Palacci"}],"external_id":{"pmid":["35951689 "]},"abstract":[{"lang":"eng","text":"If you mix fruit syrups with alcohol to make a schnapps, the two liquids will remain perfectly blended forever. But if you mix oil with vinegar to make a vinaigrette, the oil and vinegar will soon separate back into their previous selves. Such liquid-liquid phase separation is a thermodynamically driven phenomenon and plays an important role in many biological processes (1). Although energy injection at the macroscale can reverse the phase separation—a strong shake is the normal response to a separated vinaigrette—little is known about the effect of energy added at the microscopic level on phase separation. This fundamental question has deep ramifications, notably in biology, because active processes also make the interior of a living cell different from a dead one. On page 768 of this issue, Adkins et al. (2) examine how mechanical activity at the microscopic scale affects liquid-liquid phase separation and allows liquids to climb surfaces."}]},{"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"scopus_import":"1","issue":"6620","title":"Polarized x-rays from a magnetar","type":"journal_article","day":"03","status":"public","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2205.08898"}],"doi":"10.1126/science.add0080","date_created":"2024-03-26T09:51:30Z","arxiv":1,"date_published":"2022-11-03T00:00:00Z","citation":{"mla":"Taverna, Roberto, et al. “Polarized X-Rays from a Magnetar.” <i>Science</i>, vol. 378, no. 6620, American Association for the Advancement of Science, 2022, pp. 646–50, doi:<a href=\"https://doi.org/10.1126/science.add0080\">10.1126/science.add0080</a>.","ieee":"R. Taverna <i>et al.</i>, “Polarized x-rays from a magnetar,” <i>Science</i>, vol. 378, no. 6620. American Association for the Advancement of Science, pp. 646–650, 2022.","chicago":"Taverna, Roberto, Roberto Turolla, Fabio Muleri, Jeremy Heyl, Silvia Zane, Luca Baldini, Denis González-Caniulef, et al. “Polarized X-Rays from a Magnetar.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.add0080\">https://doi.org/10.1126/science.add0080</a>.","ama":"Taverna R, Turolla R, Muleri F, et al. Polarized x-rays from a magnetar. <i>Science</i>. 2022;378(6620):646-650. doi:<a href=\"https://doi.org/10.1126/science.add0080\">10.1126/science.add0080</a>","short":"R. Taverna, R. Turolla, F. Muleri, J. Heyl, S. Zane, L. Baldini, D. González-Caniulef, M. Bachetti, J. Rankin, I. Caiazzo, N. Di Lalla, V. Doroshenko, M. Errando, E. Gau, D. Kırmızıbayrak, H. Krawczynski, M. Negro, M. Ng, N. Omodei, A. Possenti, T. Tamagawa, K. Uchiyama, M.C. Weisskopf, I. Agudo, L.A. Antonelli, W.H. Baumgartner, R. Bellazzini, S. Bianchi, S.D. Bongiorno, R. Bonino, A. Brez, N. Bucciantini, F. Capitanio, S. Castellano, E. Cavazzuti, S. Ciprini, E. Costa, A. De Rosa, E. Del Monte, L. Di Gesu, A. Di Marco, I. Donnarumma, M. Dovčiak, S.R. Ehlert, T. Enoto, Y. Evangelista, S. Fabiani, R. Ferrazzoli, J.A. Garcia, S. Gunji, K. Hayashida, W. Iwakiri, S.G. Jorstad, V. Karas, T. Kitaguchi, J.J. Kolodziejczak, F. La Monaca, L. Latronico, I. Liodakis, S. Maldera, A. Manfreda, F. Marin, A. Marinucci, A.P. Marscher, H.L. Marshall, G. Matt, I. Mitsuishi, T. Mizuno, S.C.-Y. Ng, S.L. O’Dell, C. Oppedisano, A. Papitto, G.G. Pavlov, A.L. Peirson, M. Perri, M. Pesce-Rollins, M. Pilia, J. Poutanen, S. Puccetti, B.D. Ramsey, A. Ratheesh, R.W. Romani, C. Sgrò, P. Slane, P. Soffitta, G. Spandre, F. Tavecchio, Y. Tawara, A.F. Tennant, N.E. Thomas, F. Tombesi, A. Trois, S.S. Tsygankov, J. Vink, K. Wu, F. Xie, Science 378 (2022) 646–650.","apa":"Taverna, R., Turolla, R., Muleri, F., Heyl, J., Zane, S., Baldini, L., … Xie, F. (2022). Polarized x-rays from a magnetar. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.add0080\">https://doi.org/10.1126/science.add0080</a>","ista":"Taverna R, Turolla R, Muleri F, Heyl J, Zane S, Baldini L, González-Caniulef D, Bachetti M, Rankin J, Caiazzo I, Di Lalla N, Doroshenko V, Errando M, Gau E, Kırmızıbayrak D, Krawczynski H, Negro M, Ng M, Omodei N, Possenti A, Tamagawa T, Uchiyama K, Weisskopf MC, Agudo I, Antonelli LA, Baumgartner WH, Bellazzini R, Bianchi S, Bongiorno SD, Bonino R, Brez A, Bucciantini N, Capitanio F, Castellano S, Cavazzuti E, Ciprini S, Costa E, De Rosa A, Del Monte E, Di Gesu L, Di Marco A, Donnarumma I, Dovčiak M, Ehlert SR, Enoto T, Evangelista Y, Fabiani S, Ferrazzoli R, Garcia JA, Gunji S, Hayashida K, Iwakiri W, Jorstad SG, Karas V, Kitaguchi T, Kolodziejczak JJ, La Monaca F, Latronico L, Liodakis I, Maldera S, Manfreda A, Marin F, Marinucci A, Marscher AP, Marshall HL, Matt G, Mitsuishi I, Mizuno T, Ng SC-Y, O’Dell SL, Oppedisano C, Papitto A, Pavlov GG, Peirson AL, Perri M, Pesce-Rollins M, Pilia M, Poutanen J, Puccetti S, Ramsey BD, Ratheesh A, Romani RW, Sgrò C, Slane P, Soffitta P, Spandre G, Tavecchio F, Tawara Y, Tennant AF, Thomas NE, Tombesi F, Trois A, Tsygankov SS, Vink J, Wu K, Xie F. 2022. Polarized x-rays from a magnetar. Science. 378(6620), 646–650."},"intvolume":"       378","language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","month":"11","publication":"Science","article_processing_charge":"No","quality_controlled":"1","date_updated":"2024-04-02T07:17:25Z","keyword":["Multidisciplinary"],"volume":378,"year":"2022","publication_status":"published","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","page":"646-650","oa":1,"_id":"15205","oa_version":"Preprint","author":[{"last_name":"Taverna","first_name":"Roberto","full_name":"Taverna, Roberto"},{"full_name":"Turolla, Roberto","last_name":"Turolla","first_name":"Roberto"},{"last_name":"Muleri","first_name":"Fabio","full_name":"Muleri, Fabio"},{"full_name":"Heyl, Jeremy","first_name":"Jeremy","last_name":"Heyl"},{"full_name":"Zane, Silvia","last_name":"Zane","first_name":"Silvia"},{"full_name":"Baldini, Luca","last_name":"Baldini","first_name":"Luca"},{"first_name":"Denis","last_name":"González-Caniulef","full_name":"González-Caniulef, Denis"},{"first_name":"Matteo","last_name":"Bachetti","full_name":"Bachetti, Matteo"},{"last_name":"Rankin","first_name":"John","full_name":"Rankin, John"},{"last_name":"Caiazzo","first_name":"Ilaria","id":"8ae5b6e7-2a03-11ee-914d-b58ed7a3b47d","orcid":"0000-0002-4770-5388","full_name":"Caiazzo, Ilaria"},{"full_name":"Di Lalla, Niccolò","first_name":"Niccolò","last_name":"Di Lalla"},{"full_name":"Doroshenko, Victor","last_name":"Doroshenko","first_name":"Victor"},{"first_name":"Manel","last_name":"Errando","full_name":"Errando, Manel"},{"last_name":"Gau","first_name":"Ephraim","full_name":"Gau, Ephraim"},{"full_name":"Kırmızıbayrak, Demet","first_name":"Demet","last_name":"Kırmızıbayrak"},{"first_name":"Henric","last_name":"Krawczynski","full_name":"Krawczynski, Henric"},{"full_name":"Negro, Michela","last_name":"Negro","first_name":"Michela"},{"first_name":"Mason","last_name":"Ng","full_name":"Ng, Mason"},{"last_name":"Omodei","first_name":"Nicola","full_name":"Omodei, Nicola"},{"full_name":"Possenti, Andrea","first_name":"Andrea","last_name":"Possenti"},{"first_name":"Toru","last_name":"Tamagawa","full_name":"Tamagawa, Toru"},{"last_name":"Uchiyama","first_name":"Keisuke","full_name":"Uchiyama, Keisuke"},{"last_name":"Weisskopf","first_name":"Martin C.","full_name":"Weisskopf, Martin C."},{"first_name":"Ivan","last_name":"Agudo","full_name":"Agudo, Ivan"},{"first_name":"Lucio A.","last_name":"Antonelli","full_name":"Antonelli, Lucio A."},{"full_name":"Baumgartner, Wayne H.","first_name":"Wayne H.","last_name":"Baumgartner"},{"first_name":"Ronaldo","last_name":"Bellazzini","full_name":"Bellazzini, Ronaldo"},{"last_name":"Bianchi","first_name":"Stefano","full_name":"Bianchi, Stefano"},{"full_name":"Bongiorno, Stephen D.","first_name":"Stephen D.","last_name":"Bongiorno"},{"first_name":"Raffaella","last_name":"Bonino","full_name":"Bonino, Raffaella"},{"last_name":"Brez","first_name":"Alessandro","full_name":"Brez, Alessandro"},{"full_name":"Bucciantini, Niccolò","first_name":"Niccolò","last_name":"Bucciantini"},{"full_name":"Capitanio, Fiamma","first_name":"Fiamma","last_name":"Capitanio"},{"full_name":"Castellano, Simone","first_name":"Simone","last_name":"Castellano"},{"first_name":"Elisabetta","last_name":"Cavazzuti","full_name":"Cavazzuti, Elisabetta"},{"last_name":"Ciprini","first_name":"Stefano","full_name":"Ciprini, Stefano"},{"first_name":"Enrico","last_name":"Costa","full_name":"Costa, Enrico"},{"full_name":"De Rosa, Alessandra","first_name":"Alessandra","last_name":"De Rosa"},{"last_name":"Del Monte","first_name":"Ettore","full_name":"Del Monte, Ettore"},{"full_name":"Di Gesu, Laura","last_name":"Di Gesu","first_name":"Laura"},{"full_name":"Di Marco, Alessandro","last_name":"Di Marco","first_name":"Alessandro"},{"full_name":"Donnarumma, Immacolata","last_name":"Donnarumma","first_name":"Immacolata"},{"full_name":"Dovčiak, Michal","first_name":"Michal","last_name":"Dovčiak"},{"full_name":"Ehlert, Steven R.","last_name":"Ehlert","first_name":"Steven R."},{"last_name":"Enoto","first_name":"Teruaki","full_name":"Enoto, Teruaki"},{"full_name":"Evangelista, Yuri","last_name":"Evangelista","first_name":"Yuri"},{"last_name":"Fabiani","first_name":"Sergio","full_name":"Fabiani, Sergio"},{"full_name":"Ferrazzoli, Riccardo","last_name":"Ferrazzoli","first_name":"Riccardo"},{"full_name":"Garcia, Javier A.","last_name":"Garcia","first_name":"Javier A."},{"full_name":"Gunji, Shuichi","last_name":"Gunji","first_name":"Shuichi"},{"last_name":"Hayashida","first_name":"Kiyoshi","full_name":"Hayashida, Kiyoshi"},{"first_name":"Wataru","last_name":"Iwakiri","full_name":"Iwakiri, Wataru"},{"full_name":"Jorstad, Svetlana G.","last_name":"Jorstad","first_name":"Svetlana G."},{"first_name":"Vladimir","last_name":"Karas","full_name":"Karas, Vladimir"},{"last_name":"Kitaguchi","first_name":"Takao","full_name":"Kitaguchi, Takao"},{"first_name":"Jeffery J.","last_name":"Kolodziejczak","full_name":"Kolodziejczak, Jeffery J."},{"last_name":"La Monaca","first_name":"Fabio","full_name":"La Monaca, Fabio"},{"full_name":"Latronico, Luca","first_name":"Luca","last_name":"Latronico"},{"first_name":"Ioannis","last_name":"Liodakis","full_name":"Liodakis, Ioannis"},{"first_name":"Simone","last_name":"Maldera","full_name":"Maldera, Simone"},{"full_name":"Manfreda, Alberto","last_name":"Manfreda","first_name":"Alberto"},{"first_name":"Frédéric","last_name":"Marin","full_name":"Marin, Frédéric"},{"last_name":"Marinucci","first_name":"Andrea","full_name":"Marinucci, Andrea"},{"full_name":"Marscher, Alan P.","last_name":"Marscher","first_name":"Alan P."},{"full_name":"Marshall, Herman L.","first_name":"Herman L.","last_name":"Marshall"},{"last_name":"Matt","first_name":"Giorgio","full_name":"Matt, Giorgio"},{"full_name":"Mitsuishi, Ikuyuki","last_name":"Mitsuishi","first_name":"Ikuyuki"},{"first_name":"Tsunefumi","last_name":"Mizuno","full_name":"Mizuno, Tsunefumi"},{"first_name":"Stephen C.-Y.","last_name":"Ng","full_name":"Ng, Stephen C.-Y."},{"first_name":"Stephen L.","last_name":"O’Dell","full_name":"O’Dell, Stephen L."},{"full_name":"Oppedisano, Chiara","first_name":"Chiara","last_name":"Oppedisano"},{"full_name":"Papitto, Alessandro","last_name":"Papitto","first_name":"Alessandro"},{"last_name":"Pavlov","first_name":"George G.","full_name":"Pavlov, George G."},{"full_name":"Peirson, Abel L.","first_name":"Abel L.","last_name":"Peirson"},{"full_name":"Perri, Matteo","last_name":"Perri","first_name":"Matteo"},{"full_name":"Pesce-Rollins, Melissa","last_name":"Pesce-Rollins","first_name":"Melissa"},{"full_name":"Pilia, Maura","first_name":"Maura","last_name":"Pilia"},{"last_name":"Poutanen","first_name":"Juri","full_name":"Poutanen, Juri"},{"full_name":"Puccetti, Simonetta","last_name":"Puccetti","first_name":"Simonetta"},{"full_name":"Ramsey, Brian D.","first_name":"Brian D.","last_name":"Ramsey"},{"first_name":"Ajay","last_name":"Ratheesh","full_name":"Ratheesh, Ajay"},{"full_name":"Romani, Roger W.","last_name":"Romani","first_name":"Roger W."},{"first_name":"Carmelo","last_name":"Sgrò","full_name":"Sgrò, Carmelo"},{"first_name":"Patrick","last_name":"Slane","full_name":"Slane, Patrick"},{"first_name":"Paolo","last_name":"Soffitta","full_name":"Soffitta, Paolo"},{"full_name":"Spandre, Gloria","first_name":"Gloria","last_name":"Spandre"},{"full_name":"Tavecchio, Fabrizio","last_name":"Tavecchio","first_name":"Fabrizio"},{"full_name":"Tawara, Yuzuru","first_name":"Yuzuru","last_name":"Tawara"},{"full_name":"Tennant, Allyn F.","first_name":"Allyn F.","last_name":"Tennant"},{"full_name":"Thomas, Nicholas E.","first_name":"Nicholas E.","last_name":"Thomas"},{"first_name":"Francesco","last_name":"Tombesi","full_name":"Tombesi, Francesco"},{"first_name":"Alessio","last_name":"Trois","full_name":"Trois, Alessio"},{"full_name":"Tsygankov, Sergey S.","first_name":"Sergey S.","last_name":"Tsygankov"},{"last_name":"Vink","first_name":"Jacco","full_name":"Vink, Jacco"},{"first_name":"Kinwah","last_name":"Wu","full_name":"Wu, Kinwah"},{"full_name":"Xie, Fei","first_name":"Fei","last_name":"Xie"}],"external_id":{"arxiv":["2205.08898"]},"extern":"1","abstract":[{"lang":"eng","text":"Magnetars are neutron stars with ultrastrong magnetic fields, which can be observed in x-rays. Polarization measurements could provide information on their magnetic fields and surface properties. We observed polarized x-rays from the magnetar 4U 0142+61 using the Imaging X-ray Polarimetry Explorer and found a linear polarization degree of 13.5 ± 0.8% averaged over the 2– to 8–kilo–electron volt band. The polarization changes with energy: The degree is 15.0 ± 1.0% at 2 to 4 kilo–electron volts, drops below the instrumental sensitivity ~4 to 5 kilo–electron volts, and rises to 35.2 ± 7.1% at 5.5 to 8 kilo–electron volts. The polarization angle also changes by 90° at ~4 to 5 kilo–electron volts. These results are consistent with a model in which thermal radiation from the magnetar surface is reprocessed by scattering off charged particles in the magnetosphere."}]},{"OA_type":"green","title":"Late-stage diversification of indole skeletons through nitrogen atom insertion","issue":"6610","scopus_import":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"date_created":"2025-12-09T14:24:37Z","doi":"10.1126/science.add1383","main_file_link":[{"open_access":"1","url":"10.26434/chemrxiv-2022-jvfxw"}],"status":"public","day":"01","type":"journal_article","intvolume":"       377","date_published":"2022-09-01T00:00:00Z","citation":{"apa":"Reisenbauer, J., Green, O., Franchino, A., Finkelstein, P., &#38; Morandi, B. (2022). Late-stage diversification of indole skeletons through nitrogen atom insertion. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.add1383\">https://doi.org/10.1126/science.add1383</a>","ista":"Reisenbauer J, Green O, Franchino A, Finkelstein P, Morandi B. 2022. Late-stage diversification of indole skeletons through nitrogen atom insertion. Science. 377(6610), 1104–1109.","short":"J. Reisenbauer, O. Green, A. Franchino, P. Finkelstein, B. Morandi, Science 377 (2022) 1104–1109.","chicago":"Reisenbauer, Julia, Ori Green, Allegra Franchino, Patrick Finkelstein, and Bill Morandi. “Late-Stage Diversification of Indole Skeletons through Nitrogen Atom Insertion.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.add1383\">https://doi.org/10.1126/science.add1383</a>.","ieee":"J. Reisenbauer, O. Green, A. Franchino, P. Finkelstein, and B. Morandi, “Late-stage diversification of indole skeletons through nitrogen atom insertion,” <i>Science</i>, vol. 377, no. 6610. American Association for the Advancement of Science, pp. 1104–1109, 2022.","ama":"Reisenbauer J, Green O, Franchino A, Finkelstein P, Morandi B. Late-stage diversification of indole skeletons through nitrogen atom insertion. <i>Science</i>. 2022;377(6610):1104-1109. doi:<a href=\"https://doi.org/10.1126/science.add1383\">10.1126/science.add1383</a>","mla":"Reisenbauer, Julia, et al. “Late-Stage Diversification of Indole Skeletons through Nitrogen Atom Insertion.” <i>Science</i>, vol. 377, no. 6610, American Association for the Advancement of Science, 2022, pp. 1104–09, doi:<a href=\"https://doi.org/10.1126/science.add1383\">10.1126/science.add1383</a>."},"article_processing_charge":"No","quality_controlled":"1","publication":"Science","pmid":1,"month":"09","language":[{"iso":"eng"}],"OA_place":"repository","publisher":"American Association for the Advancement of Science","date_updated":"2025-12-16T11:59:34Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","year":"2022","volume":377,"oa_version":"Preprint","_id":"20763","oa":1,"article_type":"original","page":"1104-1109","extern":"1","abstract":[{"text":"Compared with peripheral late-stage transformations mainly focusing on carbon–hydrogen functionalizations, reliable strategies to directly edit the core skeleton of pharmaceutical lead compounds still remain scarce despite the recent flurry of activity in this area. Herein, we report the skeletal editing of indoles through nitrogen atom insertion, accessing the corresponding quinazoline or quinoxaline bioisosteres by trapping of an electrophilic nitrene species generated from ammonium carbamate and hypervalent iodine. This reactivity relies on the strategic use of a silyl group as a labile protecting group that can facilitate subsequent product release. The utility of this highly functional group-compatible methodology in the context of late-stage skeletal editing of several commercial drugs is demonstrated.","lang":"eng"}],"author":[{"last_name":"Reisenbauer","first_name":"Julia","id":"51d862e9-36ee-11f0-86d3-8534c85a5496","full_name":"Reisenbauer, Julia"},{"first_name":"Ori","last_name":"Green","full_name":"Green, Ori"},{"full_name":"Franchino, Allegra","last_name":"Franchino","first_name":"Allegra"},{"full_name":"Finkelstein, Patrick","last_name":"Finkelstein","first_name":"Patrick"},{"full_name":"Morandi, Bill","first_name":"Bill","last_name":"Morandi"}],"external_id":{"pmid":["36048958"]}},{"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"scopus_import":"1","issue":"6583","title":"A framework for scintillation in nanophotonics","OA_type":"green","type":"journal_article","day":"25","status":"public","date_created":"2026-03-30T12:22:48Z","arxiv":1,"doi":"10.1126/science.abm9293","main_file_link":[{"open_access":"1","url":"https://doi.org/10.48550/arXiv.2110.11492"}],"citation":{"short":"C. Roques-Carmes, N. Rivera, A. Ghorashi, S.E. Kooi, Y. Yang, Z. Lin, J. Beroz, A. Massuda, J. Sloan, N. Romeo, Y. Yu, J.D. Joannopoulos, I. Kaminer, S.G. Johnson, M. Soljačić, Science 375 (2022).","apa":"Roques-Carmes, C., Rivera, N., Ghorashi, A., Kooi, S. E., Yang, Y., Lin, Z., … Soljačić, M. (2022). A framework for scintillation in nanophotonics. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.abm9293\">https://doi.org/10.1126/science.abm9293</a>","ista":"Roques-Carmes C, Rivera N, Ghorashi A, Kooi SE, Yang Y, Lin Z, Beroz J, Massuda A, Sloan J, Romeo N, Yu Y, Joannopoulos JD, Kaminer I, Johnson SG, Soljačić M. 2022. A framework for scintillation in nanophotonics. Science. 375(6583), 837.","mla":"Roques-Carmes, Charles, et al. “A Framework for Scintillation in Nanophotonics.” <i>Science</i>, vol. 375, no. 6583, 837, American Association for the Advancement of Science, 2022, doi:<a href=\"https://doi.org/10.1126/science.abm9293\">10.1126/science.abm9293</a>.","ieee":"C. Roques-Carmes <i>et al.</i>, “A framework for scintillation in nanophotonics,” <i>Science</i>, vol. 375, no. 6583. American Association for the Advancement of Science, 2022.","chicago":"Roques-Carmes, Charles, Nicholas Rivera, Ali Ghorashi, Steven E. Kooi, Yi Yang, Zin Lin, Justin Beroz, et al. “A Framework for Scintillation in Nanophotonics.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.abm9293\">https://doi.org/10.1126/science.abm9293</a>.","ama":"Roques-Carmes C, Rivera N, Ghorashi A, et al. A framework for scintillation in nanophotonics. <i>Science</i>. 2022;375(6583). doi:<a href=\"https://doi.org/10.1126/science.abm9293\">10.1126/science.abm9293</a>"},"date_published":"2022-02-25T00:00:00Z","intvolume":"       375","article_number":"837","OA_place":"repository","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"month":"02","publication":"Science","quality_controlled":"1","article_processing_charge":"No","date_updated":"2026-04-27T09:06:48Z","volume":375,"year":"2022","publication_status":"published","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","article_type":"original","oa":1,"_id":"21584","oa_version":"Preprint","external_id":{"arxiv":["2110.11492"]},"author":[{"last_name":"Roques-Carmes","first_name":"Charles","id":"e2e68fc9-6505-11ef-a541-eb4e72cc3e82","full_name":"Roques-Carmes, Charles"},{"full_name":"Rivera, Nicholas","last_name":"Rivera","first_name":"Nicholas"},{"last_name":"Ghorashi","first_name":"Ali","full_name":"Ghorashi, Ali"},{"last_name":"Kooi","first_name":"Steven E.","full_name":"Kooi, Steven E."},{"last_name":"Yang","first_name":"Yi","full_name":"Yang, Yi"},{"full_name":"Lin, Zin","first_name":"Zin","last_name":"Lin"},{"last_name":"Beroz","first_name":"Justin","full_name":"Beroz, Justin"},{"first_name":"Aviram","last_name":"Massuda","full_name":"Massuda, Aviram"},{"full_name":"Sloan, Jamison","last_name":"Sloan","first_name":"Jamison"},{"last_name":"Romeo","first_name":"Nicolas","full_name":"Romeo, Nicolas"},{"last_name":"Yu","first_name":"Yang","full_name":"Yu, Yang"},{"full_name":"Joannopoulos, John D.","last_name":"Joannopoulos","first_name":"John D."},{"first_name":"Ido","last_name":"Kaminer","full_name":"Kaminer, Ido"},{"last_name":"Johnson","first_name":"Steven G.","full_name":"Johnson, Steven G."},{"last_name":"Soljačić","first_name":"Marin","full_name":"Soljačić, Marin"}],"abstract":[{"text":"Bombardment of materials by high-energy particles often leads to light emission in a process known as scintillation. Scintillation has widespread applications in medical imaging, x-ray nondestructive inspection, electron microscopy, and high-energy particle detectors. Most research focuses on finding materials with brighter, faster, and more controlled scintillation. We developed a unified theory of nanophotonic scintillators that accounts for the key aspects of scintillation: energy loss by high-energy particles, and light emission by non-equilibrium electrons in nanostructured optical systems. We then devised an approach based on integrating nanophotonic structures into scintillators to enhance their emission, obtaining nearly an order-of-magnitude enhancement in both electron-induced and x-ray–induced scintillation. Our framework should enable the development of a new class of brighter, faster, and higher-resolution scintillators with tailored and optimized performance.","lang":"eng"}],"extern":"1"},{"intvolume":"       378","citation":{"mla":"Chhugani, Karishma, et al. “Remote Opportunities for Scholars in Ukraine.” <i>Science</i>, vol. 378, no. 6626, American Association for the Advancement of Science, 2022, pp. 1285–86, doi:<a href=\"https://doi.org/10.1126/science.adg0797\">10.1126/science.adg0797</a>.","ama":"Chhugani K, Frolova A, Salyha Y, et al. Remote opportunities for scholars in Ukraine. <i>Science</i>. 2022;378(6626):1285-1286. doi:<a href=\"https://doi.org/10.1126/science.adg0797\">10.1126/science.adg0797</a>","ieee":"K. Chhugani <i>et al.</i>, “Remote opportunities for scholars in Ukraine,” <i>Science</i>, vol. 378, no. 6626. American Association for the Advancement of Science, pp. 1285–1286, 2022.","chicago":"Chhugani, Karishma, Alina Frolova, Yuriy Salyha, Andrada Fiscutean, Oksana Zlenko, Sanita Reinsone, Walter W. Wolfsberger, et al. “Remote Opportunities for Scholars in Ukraine.” <i>Science</i>. American Association for the Advancement of Science, 2022. <a href=\"https://doi.org/10.1126/science.adg0797\">https://doi.org/10.1126/science.adg0797</a>.","short":"K. Chhugani, A. Frolova, Y. Salyha, A. Fiscutean, O. Zlenko, S. Reinsone, W.W. Wolfsberger, O.V. Ivashchenko, M. Maci, D. Dziuba, A. Parkhomenko, E. Bortz, F. Kondrashov, P.P. Łabaj, V. Romero, J. Hlávka, T.K. Oleksyk, S. Mangul, Science 378 (2022) 1285–1286.","apa":"Chhugani, K., Frolova, A., Salyha, Y., Fiscutean, A., Zlenko, O., Reinsone, S., … Mangul, S. (2022). Remote opportunities for scholars in Ukraine. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.adg0797\">https://doi.org/10.1126/science.adg0797</a>","ista":"Chhugani K, Frolova A, Salyha Y, Fiscutean A, Zlenko O, Reinsone S, Wolfsberger WW, Ivashchenko OV, Maci M, Dziuba D, Parkhomenko A, Bortz E, Kondrashov F, Łabaj PP, Romero V, Hlávka J, Oleksyk TK, Mangul S. 2022. Remote opportunities for scholars in Ukraine. Science. 378(6626), 1285–1286."},"date_published":"2022-12-22T00:00:00Z","publication":"Science","quality_controlled":"1","article_processing_charge":"No","publisher":"American Association for the Advancement of Science","language":[{"iso":"eng"}],"month":"12","pmid":1,"issue":"6626","title":"Remote opportunities for scholars in Ukraine","scopus_import":"1","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"ddc":["000"],"status":"public","date_created":"2023-01-12T11:56:30Z","doi":"10.1126/science.adg0797","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1126/science.adg0797"}],"day":"22","type":"journal_article","_id":"12116","oa_version":"Published Version","article_type":"letter_note","page":"1285-1286","oa":1,"external_id":{"isi":["000963463700023"],"pmid":["36548425"]},"author":[{"last_name":"Chhugani","first_name":"Karishma","full_name":"Chhugani, Karishma"},{"full_name":"Frolova, Alina","last_name":"Frolova","first_name":"Alina"},{"full_name":"Salyha, Yuriy","last_name":"Salyha","first_name":"Yuriy"},{"first_name":"Andrada","last_name":"Fiscutean","full_name":"Fiscutean, Andrada"},{"first_name":"Oksana","last_name":"Zlenko","full_name":"Zlenko, Oksana"},{"full_name":"Reinsone, Sanita","first_name":"Sanita","last_name":"Reinsone"},{"last_name":"Wolfsberger","first_name":"Walter W.","full_name":"Wolfsberger, Walter W."},{"full_name":"Ivashchenko, Oleksandra V.","last_name":"Ivashchenko","first_name":"Oleksandra V."},{"last_name":"Maci","first_name":"Megi","full_name":"Maci, Megi"},{"last_name":"Dziuba","first_name":"Dmytro","full_name":"Dziuba, Dmytro"},{"first_name":"Andrii","last_name":"Parkhomenko","full_name":"Parkhomenko, Andrii"},{"full_name":"Bortz, Eric","last_name":"Bortz","first_name":"Eric"},{"full_name":"Kondrashov, Fyodor","orcid":"0000-0001-8243-4694","id":"44FDEF62-F248-11E8-B48F-1D18A9856A87","first_name":"Fyodor","last_name":"Kondrashov"},{"full_name":"Łabaj, Paweł P.","last_name":"Łabaj","first_name":"Paweł P."},{"full_name":"Romero, Veronika","last_name":"Romero","first_name":"Veronika"},{"full_name":"Hlávka, Jakub","last_name":"Hlávka","first_name":"Jakub"},{"full_name":"Oleksyk, Taras K.","last_name":"Oleksyk","first_name":"Taras K."},{"last_name":"Mangul","first_name":"Serghei","full_name":"Mangul, Serghei"}],"abstract":[{"lang":"eng","text":"Russia’s unprovoked attack on Ukraine has destroyed civilian infrastructure, including universities, research centers, and other academic infrastructure (1). Many Ukrainian scholars and researchers remain in Ukraine, and their work has suffered from major setbacks (2–4). We call on international scientists and institutions to support them."}],"department":[{"_id":"FyKo"}],"date_updated":"2026-06-18T17:22:36Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","isi":1,"year":"2022","volume":378,"publication_status":"published"}]