[{"intvolume":"       337","_id":"12198","type":"journal_article","language":[{"iso":"eng"}],"title":"Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes","article_processing_charge":"No","pmid":1,"date_published":"2012-09-14T00:00:00Z","extern":"1","department":[{"_id":"XiFe"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"acknowledgement":"We thank S. Harmer for assistance with the analysis of histone modifications, the BioOptics team at the Vienna Biocenter Campus for sorting sperm and vegetative cell nuclei, K. Slotkin for the LAT52p-amiRNA=GFP plasmid, and G. Drews for the DD45p-GFP transgenic line. This work was partially funded by an NIH grant (GM69415) to R.L.F., NSF grants (MCB-0918821 and IOS-1025890) to R.L.F. and D.Z., a Young Investigator Grant from the Arnold and Mabel Beckman Foundation to D.Z., an Austrian Science Fund (FWF) grant P21389-B03 to H.T., a Ruth L. Kirschstein NIH Predoctoral Fellowship (GM093633) to C.A.I., a Fulbright Scholarship to J.A.R., a fellowship from the Jane Coffin Childs Memorial Fund to A.Z., and a Robert and Colleen Haas Scholarship to D.R. Sequencing data are deposited in GEO (GSE38935).","date_created":"2023-01-16T09:21:24Z","publication":"Science","date_updated":"2025-01-14T12:37:28Z","year":"2012","abstract":[{"lang":"eng","text":"The Arabidopsis thaliana central cell, the companion cell of the egg, undergoes DNA demethylation before fertilization, but the targeting preferences, mechanism, and biological significance of this process remain unclear. Here, we show that active DNA demethylation mediated by the DEMETER DNA glycosylase accounts for all of the demethylation in the central cell and preferentially targets small, AT-rich, and nucleosome-depleted euchromatic transposable elements. The vegetative cell, the companion cell of sperm, also undergoes DEMETER-dependent demethylation of similar sequences, and lack of DEMETER in vegetative cells causes reduced small RNA–directed DNA methylation of transposons in sperm. Our results demonstrate that demethylation in companion cells reinforces transposon methylation in plant gametes and likely contributes to stable silencing of transposable elements across generations."}],"external_id":{"pmid":["22984074"]},"month":"09","article_type":"original","oa_version":"Published Version","status":"public","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034762/","open_access":"1"}],"issue":"6100","keyword":["Multidisciplinary"],"doi":"10.1126/science.1224839","quality_controlled":"1","author":[{"first_name":"Christian A.","full_name":"Ibarra, Christian A.","last_name":"Ibarra"},{"orcid":"0000-0002-4008-1234","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","first_name":"Xiaoqi","last_name":"Feng","full_name":"Feng, Xiaoqi"},{"full_name":"Schoft, Vera K.","last_name":"Schoft","first_name":"Vera K."},{"full_name":"Hsieh, Tzung-Fu","last_name":"Hsieh","first_name":"Tzung-Fu"},{"first_name":"Rie","full_name":"Uzawa, Rie","last_name":"Uzawa"},{"first_name":"Jessica A.","last_name":"Rodrigues","full_name":"Rodrigues, Jessica A."},{"first_name":"Assaf","last_name":"Zemach","full_name":"Zemach, Assaf"},{"full_name":"Chumak, Nina","last_name":"Chumak","first_name":"Nina"},{"last_name":"Machlicova","full_name":"Machlicova, Adriana","first_name":"Adriana"},{"first_name":"Toshiro","last_name":"Nishimura","full_name":"Nishimura, Toshiro"},{"full_name":"Rojas, Denisse","last_name":"Rojas","first_name":"Denisse"},{"full_name":"Fischer, Robert L.","last_name":"Fischer","first_name":"Robert L."},{"first_name":"Hisashi","last_name":"Tamaru","full_name":"Tamaru, Hisashi"},{"orcid":"0000-0002-0123-8649","first_name":"Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","last_name":"Zilberman","full_name":"Zilberman, Daniel"}],"day":"14","publisher":"American Association for the Advancement of Science","volume":337,"citation":{"short":"C.A. Ibarra, X. Feng, V.K. Schoft, T.-F. Hsieh, R. Uzawa, J.A. Rodrigues, A. Zemach, N. Chumak, A. Machlicova, T. Nishimura, D. Rojas, R.L. Fischer, H. Tamaru, D. Zilberman, Science 337 (2012) 1360–1364.","apa":"Ibarra, C. A., Feng, X., Schoft, V. K., Hsieh, T.-F., Uzawa, R., Rodrigues, J. A., … Zilberman, D. (2012). Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1224839\">https://doi.org/10.1126/science.1224839</a>","ista":"Ibarra CA, Feng X, Schoft VK, Hsieh T-F, Uzawa R, Rodrigues JA, Zemach A, Chumak N, Machlicova A, Nishimura T, Rojas D, Fischer RL, Tamaru H, Zilberman D. 2012. Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. Science. 337(6100), 1360–1364.","ama":"Ibarra CA, Feng X, Schoft VK, et al. Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. <i>Science</i>. 2012;337(6100):1360-1364. doi:<a href=\"https://doi.org/10.1126/science.1224839\">10.1126/science.1224839</a>","mla":"Ibarra, Christian A., et al. “Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes.” <i>Science</i>, vol. 337, no. 6100, American Association for the Advancement of Science, 2012, pp. 1360–64, doi:<a href=\"https://doi.org/10.1126/science.1224839\">10.1126/science.1224839</a>.","chicago":"Ibarra, Christian A., Xiaoqi Feng, Vera K. Schoft, Tzung-Fu Hsieh, Rie Uzawa, Jessica A. Rodrigues, Assaf Zemach, et al. “Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1224839\">https://doi.org/10.1126/science.1224839</a>.","ieee":"C. A. Ibarra <i>et al.</i>, “Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes,” <i>Science</i>, vol. 337, no. 6100. American Association for the Advancement of Science, pp. 1360–1364, 2012."},"publication_status":"published","page":"1360-1364","scopus_import":"1"},{"language":[{"iso":"eng"}],"title":"Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes","article_processing_charge":"No","date_published":"2012-09-14T00:00:00Z","pmid":1,"intvolume":"       337","_id":"9451","type":"journal_article","has_accepted_license":"1","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"date_updated":"2021-12-14T08:28:51Z","year":"2012","date_created":"2021-06-04T07:51:31Z","publication":"Science","abstract":[{"text":"The Arabidopsis thaliana central cell, the companion cell of the egg, undergoes DNA demethylation before fertilization, but the targeting preferences, mechanism, and biological significance of this process remain unclear. Here, we show that active DNA demethylation mediated by the DEMETER DNA glycosylase accounts for all of the demethylation in the central cell and preferentially targets small, AT-rich, and nucleosome-depleted euchromatic transposable elements. The vegetative cell, the companion cell of sperm, also undergoes DEMETER-dependent demethylation of similar sequences, and lack of DEMETER in vegetative cells causes reduced small RNA–directed DNA methylation of transposons in sperm. Our results demonstrate that demethylation in companion cells reinforces transposon methylation in plant gametes and likely contributes to stable silencing of transposable elements across generations.","lang":"eng"}],"external_id":{"pmid":["22984074"]},"department":[{"_id":"DaZi"}],"extern":"1","oa":1,"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","quality_controlled":"1","doi":"10.1126/science.1224839","article_type":"original","month":"09","oa_version":"Published Version","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4034762/"}],"status":"public","issue":"6100","ddc":["580"],"citation":{"short":"C.A. Ibarra, X. Feng, V.K. Schoft, T.-F. Hsieh, R. Uzawa, J.A. Rodrigues, A. Zemach, N. Chumak, A. Machlicova, T. Nishimura, D. Rojas, R.L. Fischer, H. Tamaru, D. Zilberman, Science 337 (2012) 1360–1364.","apa":"Ibarra, C. A., Feng, X., Schoft, V. K., Hsieh, T.-F., Uzawa, R., Rodrigues, J. A., … Zilberman, D. (2012). Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1224839\">https://doi.org/10.1126/science.1224839</a>","mla":"Ibarra, Christian A., et al. “Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes.” <i>Science</i>, vol. 337, no. 6100, American Association for the Advancement of Science, 2012, pp. 1360–64, doi:<a href=\"https://doi.org/10.1126/science.1224839\">10.1126/science.1224839</a>.","ama":"Ibarra CA, Feng X, Schoft VK, et al. Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. <i>Science</i>. 2012;337(6100):1360-1364. doi:<a href=\"https://doi.org/10.1126/science.1224839\">10.1126/science.1224839</a>","ista":"Ibarra CA, Feng X, Schoft VK, Hsieh T-F, Uzawa R, Rodrigues JA, Zemach A, Chumak N, Machlicova A, Nishimura T, Rojas D, Fischer RL, Tamaru H, Zilberman D. 2012. Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes. Science. 337(6100), 1360–1364.","chicago":"Ibarra, Christian A., Xiaoqi Feng, Vera K. Schoft, Tzung-Fu Hsieh, Rie Uzawa, Jessica A. Rodrigues, Assaf Zemach, et al. “Active DNA Demethylation in Plant Companion Cells Reinforces Transposon Methylation in Gametes.” <i>Science</i>. American Association for the Advancement of Science, 2012. <a href=\"https://doi.org/10.1126/science.1224839\">https://doi.org/10.1126/science.1224839</a>.","ieee":"C. A. Ibarra <i>et al.</i>, “Active DNA demethylation in plant companion cells reinforces transposon methylation in gametes,” <i>Science</i>, vol. 337, no. 6100. American Association for the Advancement of Science, pp. 1360–1364, 2012."},"page":"1360-1364","publication_status":"published","scopus_import":"1","author":[{"full_name":"Ibarra, Christian A.","last_name":"Ibarra","first_name":"Christian A."},{"first_name":"Xiaoqi","last_name":"Feng","full_name":"Feng, Xiaoqi"},{"full_name":"Schoft, Vera K.","last_name":"Schoft","first_name":"Vera K."},{"first_name":"Tzung-Fu","full_name":"Hsieh, Tzung-Fu","last_name":"Hsieh"},{"first_name":"Rie","full_name":"Uzawa, Rie","last_name":"Uzawa"},{"full_name":"Rodrigues, Jessica A.","last_name":"Rodrigues","first_name":"Jessica A."},{"last_name":"Zemach","full_name":"Zemach, Assaf","first_name":"Assaf"},{"first_name":"Nina","last_name":"Chumak","full_name":"Chumak, Nina"},{"last_name":"Machlicova","full_name":"Machlicova, Adriana","first_name":"Adriana"},{"full_name":"Nishimura, Toshiro","last_name":"Nishimura","first_name":"Toshiro"},{"last_name":"Rojas","full_name":"Rojas, Denisse","first_name":"Denisse"},{"first_name":"Robert L.","last_name":"Fischer","full_name":"Fischer, Robert L."},{"full_name":"Tamaru, Hisashi","last_name":"Tamaru","first_name":"Hisashi"},{"id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","first_name":"Daniel","orcid":"0000-0002-0123-8649","full_name":"Zilberman, Daniel","last_name":"Zilberman"}],"day":"14","publisher":"American Association for the Advancement of Science","volume":337},{"language":[{"iso":"eng"}],"article_processing_charge":"No","title":"A reversible and higher-rate Li-O2 battery","doi":"10.1126/science.1223985","quality_controlled":"1","date_published":"2012-08-03T00:00:00Z","month":"08","article_type":"original","oa_version":"None","intvolume":"       337","_id":"7310","type":"journal_article","status":"public","issue":"6094","citation":{"short":"Z. Peng, S.A. Freunberger, Y. Chen, P.G. Bruce, Science 337 (2012) 563–566.","apa":"Peng, Z., Freunberger, S. A., Chen, Y., &#38; Bruce, P. G. (2012). A reversible and higher-rate Li-O2 battery. <i>Science</i>. AAAS. <a href=\"https://doi.org/10.1126/science.1223985\">https://doi.org/10.1126/science.1223985</a>","ista":"Peng Z, Freunberger SA, Chen Y, Bruce PG. 2012. A reversible and higher-rate Li-O2 battery. Science. 337(6094), 563–566.","chicago":"Peng, Z., Stefan Alexander Freunberger, Y. Chen, and P. G. Bruce. “A Reversible and Higher-Rate Li-O2 Battery.” <i>Science</i>. AAAS, 2012. <a href=\"https://doi.org/10.1126/science.1223985\">https://doi.org/10.1126/science.1223985</a>.","ama":"Peng Z, Freunberger SA, Chen Y, Bruce PG. A reversible and higher-rate Li-O2 battery. <i>Science</i>. 2012;337(6094):563-566. doi:<a href=\"https://doi.org/10.1126/science.1223985\">10.1126/science.1223985</a>","mla":"Peng, Z., et al. “A Reversible and Higher-Rate Li-O2 Battery.” <i>Science</i>, vol. 337, no. 6094, AAAS, 2012, pp. 563–66, doi:<a href=\"https://doi.org/10.1126/science.1223985\">10.1126/science.1223985</a>.","ieee":"Z. Peng, S. A. Freunberger, Y. Chen, and P. G. Bruce, “A reversible and higher-rate Li-O2 battery,” <i>Science</i>, vol. 337, no. 6094. AAAS, pp. 563–566, 2012."},"publication_identifier":{"issn":["0036-8075","1095-9203"]},"date_created":"2020-01-15T12:19:23Z","publication":"Science","date_updated":"2021-01-12T08:12:57Z","page":"563-566","year":"2012","publication_status":"published","abstract":[{"text":"The rechargeable nonaqueous lithium-air (Li-O2) battery is receiving a great deal of interest because, theoretically, its specific energy far exceeds the best that can be achieved with lithium-ion cells. Operation of the rechargeable Li-O2 battery depends critically on repeated and highly reversible formation/decomposition of lithium peroxide (Li2O2) at the cathode upon cycling. Here, we show that this process is possible with the use of a dimethyl sulfoxide electrolyte and a porous gold electrode (95% capacity retention from cycles 1 to 100), whereas previously only partial Li2O2 formation/decomposition and limited cycling could occur. Furthermore, we present data indicating that the kinetics of Li2O2 oxidation on charge is approximately 10 times faster than on carbon electrodes.","lang":"eng"}],"author":[{"full_name":"Peng, Z.","last_name":"Peng","first_name":"Z."},{"orcid":"0000-0003-2902-5319","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","first_name":"Stefan Alexander","last_name":"Freunberger","full_name":"Freunberger, Stefan Alexander"},{"first_name":"Y.","last_name":"Chen","full_name":"Chen, Y."},{"last_name":"Bruce","full_name":"Bruce, P. G.","first_name":"P. G."}],"extern":"1","day":"03","publisher":"AAAS","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":337},{"abstract":[{"text":"Cortical neurons receive balanced excitatory and inhibitory synaptic currents. Such a balance could be established and maintained in an experience-dependent manner by synaptic plasticity at inhibitory synapses. We show that this mechanism provides an explanation for the sparse firing patterns observed in response to natural stimuli and fits well with a recently observed interaction of excitatory and inhibitory receptive field plasticity. The introduction of inhibitory plasticity in suitable recurrent networks provides a homeostatic mechanism that leads to asynchronous irregular network states. Further, it can accommodate synaptic memories with activity patterns that become indiscernible from the background state but can be reactivated by external stimuli. Our results suggest an essential role of inhibitory plasticity in the formation and maintenance of functional cortical circuitry.","lang":"eng"}],"external_id":{"pmid":["22075724"]},"publication_identifier":{"issn":["0036-8075","1095-9203"]},"date_created":"2020-06-30T13:26:17Z","publication":"Science","date_updated":"2021-06-02T14:57:22Z","year":"2011","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","extern":"1","article_processing_charge":"No","title":"Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks","pmid":1,"date_published":"2011-12-16T00:00:00Z","language":[{"iso":"eng"}],"type":"journal_article","_id":"8074","intvolume":"       334","scopus_import":"1","citation":{"ieee":"T. P. Vogels, H. Sprekeler, F. Zenke, C. Clopath, and W. Gerstner, “Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks,” <i>Science</i>, vol. 334, no. 6062. American Association for the Advancement of Science, pp. 1569–1573, 2011.","ista":"Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W. 2011. Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks. Science. 334(6062), 1569–1573.","chicago":"Vogels, Tim P, H. Sprekeler, F. Zenke, C. Clopath, and W. Gerstner. “Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks.” <i>Science</i>. American Association for the Advancement of Science, 2011. <a href=\"https://doi.org/10.1126/science.1211095\">https://doi.org/10.1126/science.1211095</a>.","mla":"Vogels, Tim P., et al. “Inhibitory Plasticity Balances Excitation and Inhibition in Sensory Pathways and Memory Networks.” <i>Science</i>, vol. 334, no. 6062, American Association for the Advancement of Science, 2011, pp. 1569–73, doi:<a href=\"https://doi.org/10.1126/science.1211095\">10.1126/science.1211095</a>.","ama":"Vogels TP, Sprekeler H, Zenke F, Clopath C, Gerstner W. Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks. <i>Science</i>. 2011;334(6062):1569-1573. doi:<a href=\"https://doi.org/10.1126/science.1211095\">10.1126/science.1211095</a>","short":"T.P. Vogels, H. Sprekeler, F. Zenke, C. Clopath, W. Gerstner, Science 334 (2011) 1569–1573.","apa":"Vogels, T. P., Sprekeler, H., Zenke, F., Clopath, C., &#38; Gerstner, W. (2011). Inhibitory plasticity balances excitation and inhibition in sensory pathways and memory networks. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1211095\">https://doi.org/10.1126/science.1211095</a>"},"page":"1569-1573","publication_status":"published","publisher":"American Association for the Advancement of Science","volume":334,"author":[{"full_name":"Vogels, Tim P","last_name":"Vogels","first_name":"Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","orcid":"0000-0003-3295-6181"},{"first_name":"H.","last_name":"Sprekeler","full_name":"Sprekeler, H."},{"full_name":"Zenke, F.","last_name":"Zenke","first_name":"F."},{"last_name":"Clopath","full_name":"Clopath, C.","first_name":"C."},{"full_name":"Gerstner, W.","last_name":"Gerstner","first_name":"W."}],"day":"16","related_material":{"link":[{"url":"https://doi.org/10.1126/science.336.6083.802-c","relation":"erratum"}]},"quality_controlled":"1","doi":"10.1126/science.1211095","status":"public","issue":"6062","month":"12","article_type":"original","oa_version":"None"},{"title":"Genome-wide evolutionary analysis of eukaryotic DNA methylation","article_processing_charge":"No","date_published":"2010-05-14T00:00:00Z","pmid":1,"language":[{"iso":"eng"}],"type":"journal_article","_id":"9452","intvolume":"       328","abstract":[{"text":"Eukaryotic cytosine methylation represses transcription but also occurs in the bodies of active genes, and the extent of methylation biology conservation is unclear. We quantified DNA methylation in 17 eukaryotic genomes and found that gene body methylation is conserved between plants and animals, whereas selective methylation of transposons is not. We show that methylation of plant transposons in the CHG context extends to green algae and that exclusion of histone H2A.Z from methylated DNA is conserved between plants and animals, and we present evidence for RNA-directed DNA methylation of fungal genes. Our data demonstrate that extant DNA methylation systems are mosaics of conserved and derived features, and indicate that gene body methylation is an ancient property of eukaryotic genomes.","lang":"eng"}],"external_id":{"pmid":["20395474 "]},"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"year":"2010","date_updated":"2021-12-14T08:35:37Z","publication":"Science","date_created":"2021-06-04T08:26:08Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","department":[{"_id":"DaZi"}],"extern":"1","quality_controlled":"1","doi":"10.1126/science.1186366","status":"public","keyword":["Multidisciplinary"],"issue":"5980","article_type":"original","month":"05","oa_version":"None","scopus_import":"1","citation":{"ama":"Zemach A, McDaniel IE, Silva P, Zilberman D. Genome-wide evolutionary analysis of eukaryotic DNA methylation. <i>Science</i>. 2010;328(5980):916-919. doi:<a href=\"https://doi.org/10.1126/science.1186366\">10.1126/science.1186366</a>","mla":"Zemach, Assaf, et al. “Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation.” <i>Science</i>, vol. 328, no. 5980, American Association for the Advancement of Science, 2010, pp. 916–19, doi:<a href=\"https://doi.org/10.1126/science.1186366\">10.1126/science.1186366</a>.","ista":"Zemach A, McDaniel IE, Silva P, Zilberman D. 2010. Genome-wide evolutionary analysis of eukaryotic DNA methylation. Science. 328(5980), 916–919.","chicago":"Zemach, Assaf , Ivy E. McDaniel, Pedro Silva, and Daniel Zilberman. “Genome-Wide Evolutionary Analysis of Eukaryotic DNA Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2010. <a href=\"https://doi.org/10.1126/science.1186366\">https://doi.org/10.1126/science.1186366</a>.","short":"A. Zemach, I.E. McDaniel, P. Silva, D. Zilberman, Science 328 (2010) 916–919.","apa":"Zemach, A., McDaniel, I. E., Silva, P., &#38; Zilberman, D. (2010). Genome-wide evolutionary analysis of eukaryotic DNA methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1186366\">https://doi.org/10.1126/science.1186366</a>","ieee":"A. Zemach, I. E. McDaniel, P. Silva, and D. Zilberman, “Genome-wide evolutionary analysis of eukaryotic DNA methylation,” <i>Science</i>, vol. 328, no. 5980. American Association for the Advancement of Science, pp. 916–919, 2010."},"page":"916-919","publication_status":"published","publisher":"American Association for the Advancement of Science","volume":328,"author":[{"last_name":"Zemach","full_name":"Zemach, Assaf ","first_name":"Assaf "},{"first_name":"Ivy E.","full_name":"McDaniel, Ivy E.","last_name":"McDaniel"},{"last_name":"Silva","full_name":"Silva, Pedro","first_name":"Pedro"},{"full_name":"Zilberman, Daniel","last_name":"Zilberman","orcid":"0000-0002-0123-8649","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","first_name":"Daniel"}],"day":"14"},{"intvolume":"       324","_id":"9453","type":"journal_article","language":[{"iso":"eng"}],"pmid":1,"date_published":"2009-06-12T00:00:00Z","title":"Genome-wide demethylation of Arabidopsis endosperm","article_processing_charge":"No","extern":"1","department":[{"_id":"DaZi"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","oa":1,"date_created":"2021-06-04T08:55:41Z","publication":"Science","date_updated":"2021-12-14T08:53:26Z","year":"2009","publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"external_id":{"pmid":["19520962"]},"abstract":[{"text":"Parent-of-origin-specific (imprinted) gene expression is regulated in Arabidopsis thaliana endosperm by cytosine demethylation of the maternal genome mediated by the DNA glycosylase DEMETER, but the extent of the methylation changes is not known. Here, we show that virtually the entire endosperm genome is demethylated, coupled with extensive local non-CG hypermethylation of small interfering RNA–targeted sequences. Mutation of DEMETER partially restores endosperm CG methylation to levels found in other tissues, indicating that CG demethylation is specific to maternal sequences. Endosperm demethylation is accompanied by CHH hypermethylation of embryo transposable elements. Our findings demonstrate extensive reconfiguration of the endosperm methylation landscape that likely reinforces transposon silencing in the embryo.","lang":"eng"}],"oa_version":"Submitted Version","month":"06","article_type":"original","issue":"5933","keyword":["Multidisciplinary"],"status":"public","main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4044190/","open_access":"1"}],"doi":"10.1126/science.1172417","quality_controlled":"1","day":"12","author":[{"full_name":"Hsieh, Tzung-Fu","last_name":"Hsieh","first_name":"Tzung-Fu"},{"first_name":"Christian A.","full_name":"Ibarra, Christian A.","last_name":"Ibarra"},{"full_name":"Silva, Pedro","last_name":"Silva","first_name":"Pedro"},{"first_name":"Assaf","last_name":"Zemach","full_name":"Zemach, Assaf"},{"first_name":"Leor","full_name":"Eshed-Williams, Leor","last_name":"Eshed-Williams"},{"first_name":"Robert L.","last_name":"Fischer","full_name":"Fischer, Robert L."},{"last_name":"Zilberman","full_name":"Zilberman, Daniel","orcid":"0000-0002-0123-8649","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","first_name":"Daniel"}],"volume":324,"publisher":"American Association for the Advancement of Science","publication_status":"published","page":"1451-1454","citation":{"short":"T.-F. Hsieh, C.A. Ibarra, P. Silva, A. Zemach, L. Eshed-Williams, R.L. Fischer, D. Zilberman, Science 324 (2009) 1451–1454.","apa":"Hsieh, T.-F., Ibarra, C. A., Silva, P., Zemach, A., Eshed-Williams, L., Fischer, R. L., &#38; Zilberman, D. (2009). Genome-wide demethylation of Arabidopsis endosperm. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1172417\">https://doi.org/10.1126/science.1172417</a>","chicago":"Hsieh, Tzung-Fu, Christian A. Ibarra, Pedro Silva, Assaf Zemach, Leor Eshed-Williams, Robert L. Fischer, and Daniel Zilberman. “Genome-Wide Demethylation of Arabidopsis Endosperm.” <i>Science</i>. American Association for the Advancement of Science, 2009. <a href=\"https://doi.org/10.1126/science.1172417\">https://doi.org/10.1126/science.1172417</a>.","ista":"Hsieh T-F, Ibarra CA, Silva P, Zemach A, Eshed-Williams L, Fischer RL, Zilberman D. 2009. Genome-wide demethylation of Arabidopsis endosperm. Science. 324(5933), 1451–1454.","ama":"Hsieh T-F, Ibarra CA, Silva P, et al. Genome-wide demethylation of Arabidopsis endosperm. <i>Science</i>. 2009;324(5933):1451-1454. doi:<a href=\"https://doi.org/10.1126/science.1172417\">10.1126/science.1172417</a>","mla":"Hsieh, Tzung-Fu, et al. “Genome-Wide Demethylation of Arabidopsis Endosperm.” <i>Science</i>, vol. 324, no. 5933, American Association for the Advancement of Science, 2009, pp. 1451–54, doi:<a href=\"https://doi.org/10.1126/science.1172417\">10.1126/science.1172417</a>.","ieee":"T.-F. Hsieh <i>et al.</i>, “Genome-wide demethylation of Arabidopsis endosperm,” <i>Science</i>, vol. 324, no. 5933. American Association for the Advancement of Science, pp. 1451–1454, 2009."},"scopus_import":"1"},{"year":"2007","date_updated":"2024-11-06T12:01:07Z","date_created":"2022-08-17T07:30:07Z","publication":"Science","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"external_id":{"pmid":["17656714"]},"abstract":[{"lang":"eng","text":"About 20% of the world's population uses the Web, and a large majority thereof uses Web search engines to find information. As a result, many Web researchers are devoting much effort to improving the speed and capability of search technology."}],"extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"date_published":"2007-07-27T00:00:00Z","pmid":1,"title":"Search technologies for the internet","article_processing_charge":"No","intvolume":"       317","_id":"11884","type":"journal_article","publication_status":"published","page":"468-471","citation":{"ieee":"M. Henzinger, “Search technologies for the internet,” <i>Science</i>, vol. 317, no. 5837. American Association for the Advancement of Science, pp. 468–471, 2007.","chicago":"Henzinger, Monika. “Search Technologies for the Internet.” <i>Science</i>. American Association for the Advancement of Science, 2007. <a href=\"https://doi.org/10.1126/science.1126557\">https://doi.org/10.1126/science.1126557</a>.","ista":"Henzinger M. 2007. Search technologies for the internet. Science. 317(5837), 468–471.","ama":"Henzinger M. Search technologies for the internet. <i>Science</i>. 2007;317(5837):468-471. doi:<a href=\"https://doi.org/10.1126/science.1126557\">10.1126/science.1126557</a>","mla":"Henzinger, Monika. “Search Technologies for the Internet.” <i>Science</i>, vol. 317, no. 5837, American Association for the Advancement of Science, 2007, pp. 468–71, doi:<a href=\"https://doi.org/10.1126/science.1126557\">10.1126/science.1126557</a>.","short":"M. Henzinger, Science 317 (2007) 468–471.","apa":"Henzinger, M. (2007). Search technologies for the internet. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1126557\">https://doi.org/10.1126/science.1126557</a>"},"scopus_import":"1","day":"27","author":[{"last_name":"Henzinger","full_name":"Henzinger, Monika H","orcid":"0000-0002-5008-6530","first_name":"Monika H","id":"540c9bbd-f2de-11ec-812d-d04a5be85630"}],"volume":317,"publisher":"American Association for the Advancement of Science","quality_controlled":"1","doi":"10.1126/science.1126557","oa_version":"None","article_type":"review","month":"07","issue":"5837","status":"public"},{"publisher":"American Association for the Advancement of Science","volume":316,"author":[{"id":"8e84690e-1e48-11ed-a02b-a1e6fb8bb53b","first_name":"Rafal","full_name":"Klajn, Rafal","last_name":"Klajn"},{"first_name":"Kyle J. M.","last_name":"Bishop","full_name":"Bishop, Kyle J. M."},{"last_name":"Fialkowski","full_name":"Fialkowski, Marcin","first_name":"Marcin"},{"last_name":"Paszewski","full_name":"Paszewski, Maciej","first_name":"Maciej"},{"last_name":"Campbell","full_name":"Campbell, Christopher J.","first_name":"Christopher J."},{"first_name":"Timothy P.","last_name":"Gray","full_name":"Gray, Timothy P."},{"last_name":"Grzybowski","full_name":"Grzybowski, Bartosz A.","first_name":"Bartosz A."}],"day":"13","scopus_import":"1","citation":{"apa":"Klajn, R., Bishop, K. J. M., Fialkowski, M., Paszewski, M., Campbell, C. J., Gray, T. P., &#38; Grzybowski, B. A. (2007). Plastic and moldable metals by self-assembly of sticky nanoparticle aggregates. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1139131\">https://doi.org/10.1126/science.1139131</a>","short":"R. Klajn, K.J.M. Bishop, M. Fialkowski, M. Paszewski, C.J. Campbell, T.P. Gray, B.A. Grzybowski, Science 316 (2007) 261–264.","ista":"Klajn R, Bishop KJM, Fialkowski M, Paszewski M, Campbell CJ, Gray TP, Grzybowski BA. 2007. Plastic and moldable metals by self-assembly of sticky nanoparticle aggregates. Science. 316(5822), 261–264.","mla":"Klajn, Rafal, et al. “Plastic and Moldable Metals by Self-Assembly of Sticky Nanoparticle Aggregates.” <i>Science</i>, vol. 316, no. 5822, American Association for the Advancement of Science, 2007, pp. 261–64, doi:<a href=\"https://doi.org/10.1126/science.1139131\">10.1126/science.1139131</a>.","ama":"Klajn R, Bishop KJM, Fialkowski M, et al. Plastic and moldable metals by self-assembly of sticky nanoparticle aggregates. <i>Science</i>. 2007;316(5822):261-264. doi:<a href=\"https://doi.org/10.1126/science.1139131\">10.1126/science.1139131</a>","chicago":"Klajn, Rafal, Kyle J. M. Bishop, Marcin Fialkowski, Maciej Paszewski, Christopher J. Campbell, Timothy P. Gray, and Bartosz A. Grzybowski. “Plastic and Moldable Metals by Self-Assembly of Sticky Nanoparticle Aggregates.” <i>Science</i>. American Association for the Advancement of Science, 2007. <a href=\"https://doi.org/10.1126/science.1139131\">https://doi.org/10.1126/science.1139131</a>.","ieee":"R. Klajn <i>et al.</i>, “Plastic and moldable metals by self-assembly of sticky nanoparticle aggregates,” <i>Science</i>, vol. 316, no. 5822. American Association for the Advancement of Science, pp. 261–264, 2007."},"page":"261-264","publication_status":"published","status":"public","issue":"5822","keyword":["Multidisciplinary"],"month":"04","article_type":"letter_note","oa_version":"None","doi":"10.1126/science.1139131","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","abstract":[{"lang":"eng","text":"Deformable, spherical aggregates of metal nanoparticles connected by long-chain dithiol ligands self-assemble into nanostructured materials of macroscopic dimensions. These materials are plastic and moldable against arbitrarily shaped masters and can be thermally hardened into polycrystalline metal structures of controllable porosity. In addition, in both plastic and hardened states, the assemblies are electrically conductive and exhibit Ohmic characteristics down to ∼20 volts per meter. The self-assembly method leading to such materials is applicable both to pure metals and to bimetallic structures of various elemental compositions."}],"external_id":{"pmid":["17431176"]},"publication_identifier":{"eissn":["1095-9203"],"issn":["0036-8075"]},"publication":"Science","date_created":"2023-08-01T10:36:08Z","year":"2007","date_updated":"2023-08-08T11:28:29Z","_id":"13427","type":"journal_article","intvolume":"       316","article_processing_charge":"No","title":"Plastic and moldable metals by self-assembly of sticky nanoparticle aggregates","pmid":1,"date_published":"2007-04-13T00:00:00Z","language":[{"iso":"eng"}]},{"day":"21","author":[{"first_name":"Maximiliano A.","full_name":"D'Angelo, Maximiliano A.","last_name":"D'Angelo"},{"last_name":"Anderson","full_name":"Anderson, Daniel J.","first_name":"Daniel J."},{"first_name":"Erin","last_name":"Richard","full_name":"Richard, Erin"},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","last_name":"HETZER"}],"volume":312,"publisher":"American Association for the Advancement of Science","publication_status":"published","page":"440-443","citation":{"apa":"D’Angelo, M. A., Anderson, D. J., Richard, E., &#38; Hetzer, M. (2006). Nuclear pores form de novo from both sides of the nuclear envelope. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1124196\">https://doi.org/10.1126/science.1124196</a>","short":"M.A. D’Angelo, D.J. Anderson, E. Richard, M. Hetzer, Science 312 (2006) 440–443.","chicago":"D’Angelo, Maximiliano A., Daniel J. Anderson, Erin Richard, and Martin Hetzer. “Nuclear Pores Form de Novo from Both Sides of the Nuclear Envelope.” <i>Science</i>. American Association for the Advancement of Science, 2006. <a href=\"https://doi.org/10.1126/science.1124196\">https://doi.org/10.1126/science.1124196</a>.","mla":"D’Angelo, Maximiliano A., et al. “Nuclear Pores Form de Novo from Both Sides of the Nuclear Envelope.” <i>Science</i>, vol. 312, no. 5772, American Association for the Advancement of Science, 2006, pp. 440–43, doi:<a href=\"https://doi.org/10.1126/science.1124196\">10.1126/science.1124196</a>.","ama":"D’Angelo MA, Anderson DJ, Richard E, Hetzer M. Nuclear pores form de novo from both sides of the nuclear envelope. <i>Science</i>. 2006;312(5772):440-443. doi:<a href=\"https://doi.org/10.1126/science.1124196\">10.1126/science.1124196</a>","ista":"D’Angelo MA, Anderson DJ, Richard E, Hetzer M. 2006. Nuclear pores form de novo from both sides of the nuclear envelope. Science. 312(5772), 440–443.","ieee":"M. A. D’Angelo, D. J. Anderson, E. Richard, and M. Hetzer, “Nuclear pores form de novo from both sides of the nuclear envelope,” <i>Science</i>, vol. 312, no. 5772. American Association for the Advancement of Science, pp. 440–443, 2006."},"scopus_import":"1","oa_version":"None","month":"04","article_type":"original","issue":"5772","keyword":["Multidisciplinary"],"status":"public","doi":"10.1126/science.1124196","quality_controlled":"1","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Science","date_created":"2022-04-07T07:56:32Z","year":"2006","date_updated":"2024-10-14T11:30:50Z","publication_identifier":{"issn":["0036-8075","1095-9203"]},"external_id":{"pmid":["16627745"]},"abstract":[{"lang":"eng","text":"Nuclear pore complexes are multiprotein channels that span the double lipid bilayer of the nuclear envelope. How new pores are inserted into the intact nuclear envelope of proliferating and differentiating eukaryotic cells is unknown. We found that the Nup107-160 complex was incorporated into assembly sites in the nuclear envelope from both the nucleoplasmic and the cytoplasmic sides. Nuclear pore insertion required the generation of Ran guanosine triphosphate in the nuclear and cytoplasmic compartments. Newly formed nuclear pore complexes did not contain structural components of preexisting pores, suggesting that they can form de novo."}],"intvolume":"       312","_id":"11118","type":"journal_article","language":[{"iso":"eng"}],"pmid":1,"date_published":"2006-04-21T00:00:00Z","article_processing_charge":"No","title":"Nuclear pores form de novo from both sides of the nuclear envelope"},{"publisher":"American Association for the Advancement of Science","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","volume":303,"author":[{"full_name":"Brunet, Anne","last_name":"Brunet","first_name":"Anne"},{"id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","first_name":"Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601","last_name":"Sweeney","full_name":"Sweeney, Lora Beatrice Jaeger"},{"last_name":"Sturgill","full_name":"Sturgill, J Fitzhugh ","first_name":"J Fitzhugh "},{"first_name":"Katrin","full_name":"Chua, Katrin","last_name":"Chua"},{"first_name":"Paul","full_name":"Greer, Paul","last_name":"Greer"},{"full_name":"Lin, Yingxi","last_name":"Lin","first_name":"Yingxi"},{"full_name":"Tran, Hien","last_name":"Tran","first_name":"Hien"},{"full_name":"Ross, Sarah","last_name":"Ross","first_name":"Sarah"},{"last_name":"Mostoslavsky","full_name":"Mostoslavsky, Raul","first_name":"Raul"},{"last_name":"Cohen","full_name":"Cohen, Haim","first_name":"Haim"},{"first_name":"Linda","full_name":"Hu, Linda","last_name":"Hu"},{"first_name":"Hwei-Ling","full_name":"Chen, Hwei-Ling","last_name":"Chen"},{"full_name":"Jedrychowski, Mark","last_name":"Jedrychowski","first_name":"Mark"},{"first_name":"Steven","full_name":"Gygi, Steven","last_name":"Gygi"},{"full_name":"Sinclair, David","last_name":"Sinclair","first_name":"David"},{"last_name":"Alt","full_name":"Alt, Frederick","first_name":"Frederick"},{"last_name":"Greenberg","full_name":"Greenberg, Michael","first_name":"Michael"}],"day":"26","extern":"1","abstract":[{"lang":"eng","text":"The Sir2 deacetylase modulates organismal life-span in various species. However, the molecular mechanisms by which Sir2 increases longevity are largely unknown. We show that in mammalian cells, the Sir2 homolog SIRT1 appears to control the cellular response to stress by regulating the FOXO family of Forkhead transcription factors, a family of proteins that function as sensors of the insulin signaling pathway and as regulators of organismal longevity. SIRT1 and the FOXO transcription factor FOXO3 formed a complex in cells in response to oxidative stress, and SIRT1 deacetylated FOXO3 in vitro and within cells. SIRT1 had a dual effect on FOXO3 function: SIRT1 increased FOXO3's ability to induce cell cycle arrest and resistance to oxidative stress but inhibited FOXO3's ability to induce cell death. Thus, one way in which members of the Sir2 family of proteins may increase organismal longevity is by tipping FOXO-dependent responses away from apoptosis and toward stress resistance."}],"citation":{"chicago":"Brunet, Anne, Lora B. Sweeney, J Fitzhugh  Sturgill, Katrin Chua, Paul Greer, Yingxi Lin, Hien Tran, et al. “Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase.” <i>Science</i>. American Association for the Advancement of Science, 2004. <a href=\"https://doi.org/10.1126/science.1094637\">https://doi.org/10.1126/science.1094637</a>.","ista":"Brunet A, Sweeney LB, Sturgill JF, Chua K, Greer P, Lin Y, Tran H, Ross S, Mostoslavsky R, Cohen H, Hu L, Chen H-L, Jedrychowski M, Gygi S, Sinclair D, Alt F, Greenberg M. 2004. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. Science. 303(5666), 2011–2015.","ama":"Brunet A, Sweeney LB, Sturgill JF, et al. Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. <i>Science</i>. 2004;303(5666):2011-2015. doi:<a href=\"https://doi.org/10.1126/science.1094637\">10.1126/science.1094637</a>","mla":"Brunet, Anne, et al. “Stress-Dependent Regulation of FOXO Transcription Factors by the SIRT1 Deacetylase.” <i>Science</i>, vol. 303, no. 5666, American Association for the Advancement of Science, 2004, pp. 2011–15, doi:<a href=\"https://doi.org/10.1126/science.1094637\">10.1126/science.1094637</a>.","apa":"Brunet, A., Sweeney, L. B., Sturgill, J. F., Chua, K., Greer, P., Lin, Y., … Greenberg, M. (2004). Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1094637\">https://doi.org/10.1126/science.1094637</a>","short":"A. Brunet, L.B. Sweeney, J.F. Sturgill, K. Chua, P. Greer, Y. Lin, H. Tran, S. Ross, R. Mostoslavsky, H. Cohen, L. Hu, H.-L. Chen, M. Jedrychowski, S. Gygi, D. Sinclair, F. Alt, M. Greenberg, Science 303 (2004) 2011–2015.","ieee":"A. Brunet <i>et al.</i>, “Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase,” <i>Science</i>, vol. 303, no. 5666. American Association for the Advancement of Science, pp. 2011–2015, 2004."},"publication_identifier":{"issn":["0036-8075","1095-9203"]},"publication":"Science","date_created":"2020-04-30T10:37:41Z","year":"2004","publication_status":"published","date_updated":"2024-01-31T10:14:17Z","page":"2011-2015","status":"public","_id":"7706","type":"journal_article","issue":"5666","month":"03","article_type":"original","oa_version":"None","intvolume":"       303","title":"Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase","article_processing_charge":"No","date_published":"2004-03-26T00:00:00Z","quality_controlled":"1","doi":"10.1126/science.1094637","language":[{"iso":"eng"}]},{"external_id":{"pmid":["14988555"]},"date_created":"2021-06-04T11:12:35Z","publication":"Science","year":"2004","date_updated":"2021-12-14T09:13:53Z","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","extern":"1","department":[{"_id":"DaZi"}],"pmid":1,"date_published":"2004-02-27T00:00:00Z","title":"RNA silencing genes control de novo DNA methylation","article_processing_charge":"No","language":[{"iso":"eng"}],"_id":"9454","type":"journal_article","intvolume":"       303","scopus_import":"1","page":"1336","publication_status":"published","citation":{"apa":"Chan, S. W.-L., Zilberman, D., Xie,  Zhixin, Johansen,  Lisa K., Carrington, J. C., &#38; Jacobsen, S. E. (2004). RNA silencing genes control de novo DNA methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1095989\">https://doi.org/10.1126/science.1095989</a>","short":"S.W.-L. Chan, D. Zilberman,  Zhixin Xie,  Lisa K. Johansen, J.C. Carrington, S.E. Jacobsen, Science 303 (2004) 1336.","mla":"Chan, Simon W. L., et al. “RNA Silencing Genes Control de Novo DNA Methylation.” <i>Science</i>, vol. 303, no. 5662, American Association for the Advancement of Science, 2004, p. 1336, doi:<a href=\"https://doi.org/10.1126/science.1095989\">10.1126/science.1095989</a>.","ama":"Chan SW-L, Zilberman D, Xie  Zhixin, Johansen  Lisa K., Carrington JC, Jacobsen SE. RNA silencing genes control de novo DNA methylation. <i>Science</i>. 2004;303(5662):1336. doi:<a href=\"https://doi.org/10.1126/science.1095989\">10.1126/science.1095989</a>","ista":"Chan SW-L, Zilberman D, Xie  Zhixin, Johansen  Lisa K., Carrington JC, Jacobsen SE. 2004. RNA silencing genes control de novo DNA methylation. Science. 303(5662), 1336.","chicago":"Chan, Simon W.-L., Daniel Zilberman,  Zhixin Xie,  Lisa K. Johansen, James C. Carrington, and Steven E. Jacobsen. “RNA Silencing Genes Control de Novo DNA Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2004. <a href=\"https://doi.org/10.1126/science.1095989\">https://doi.org/10.1126/science.1095989</a>.","ieee":"S. W.-L. Chan, D. Zilberman,  Zhixin Xie,  Lisa K. Johansen, J. C. Carrington, and S. E. Jacobsen, “RNA silencing genes control de novo DNA methylation,” <i>Science</i>, vol. 303, no. 5662. American Association for the Advancement of Science, p. 1336, 2004."},"volume":303,"publisher":"American Association for the Advancement of Science","day":"27","author":[{"last_name":"Chan","full_name":"Chan, Simon W.-L.","first_name":"Simon W.-L."},{"last_name":"Zilberman","full_name":"Zilberman, Daniel","orcid":"0000-0002-0123-8649","first_name":"Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1"},{"full_name":"Xie,  Zhixin","last_name":"Xie","first_name":" Zhixin"},{"full_name":"Johansen,  Lisa K.","last_name":"Johansen","first_name":" Lisa K."},{"first_name":"James C.","last_name":"Carrington","full_name":"Carrington, James C."},{"first_name":"Steven E.","full_name":"Jacobsen, Steven E.","last_name":"Jacobsen"}],"doi":"10.1126/science.1095989","quality_controlled":"1","issue":"5662","keyword":["Multidisciplinary"],"status":"public","oa_version":"None","month":"02","article_type":"original"},{"scopus_import":"1","external_id":{"pmid":["12738868"]},"abstract":[{"lang":"eng","text":"Despite its implications for higher order functions of the brain, little is currently known about the molecular basis of left-right asymmetry of the brain. Here we report that synaptic distribution of N-methyl-D-aspartate (NMDA) receptor GluRε2 (NR2B) subunits in the adult mouse hippocampus is asymmetrical between the left and right and between the apical and basal dendrites of single neurons. These asymmetrical allocations of ε2 subunits differentiate the properties of NMDA receptors and synaptic plasticity between the left and right hippocampus. These results provide a molecular basis for the structural and functional asymmetry of the mature brain."}],"date_created":"2018-12-11T11:58:45Z","year":"2003","publication_status":"published","date_updated":"2026-05-22T11:42:53Z","page":"990 - 994","citation":{"ieee":"R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, and I. Ito, <i>Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry</i>, vol. 300. American Association for the Advancement of Science, 2003, pp. 990–994.","apa":"Kawakami, R., Shinohara, Y., Kato, Y., Sugiyama, H., Shigemoto, R., &#38; Ito, I. (2003). <i>Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry</i> (Vol. 300, pp. 990–994). American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1082609\">https://doi.org/10.1126/science.1082609</a>","short":"R. Kawakami, Y. Shinohara, Y. Kato, H. Sugiyama, R. Shigemoto, I. Ito, Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry, American Association for the Advancement of Science, 2003.","chicago":"Kawakami, Ryosuke, Yoshiaki Shinohara, Yuichiro Kato, Hiroyuki Sugiyama, Ryuichi Shigemoto, and Isao Ito. <i>Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry</i>. Vol. 300. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1082609\">https://doi.org/10.1126/science.1082609</a>.","ista":"Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. 2003. Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry, American Association for the Advancement of Science,p.","ama":"Kawakami R, Shinohara Y, Kato Y, Sugiyama H, Shigemoto R, Ito I. <i>Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry</i>. Vol 300. American Association for the Advancement of Science; 2003:990-994. doi:<a href=\"https://doi.org/10.1126/science.1082609\">10.1126/science.1082609</a>","mla":"Kawakami, Ryosuke, et al. <i>Asymmetrical Allocation of NMDA Receptor Ε2 Subunits in Hippocampal Circuitry</i>. Vol. 300, American Association for the Advancement of Science, 2003, pp. 990–94, doi:<a href=\"https://doi.org/10.1126/science.1082609\">10.1126/science.1082609</a>."},"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","volume":300,"publisher":"American Association for the Advancement of Science","publist_id":"4271","day":"09","extern":"1","author":[{"first_name":"Ryosuke","full_name":"Kawakami, Ryosuke","last_name":"Kawakami"},{"first_name":"Yoshiaki","full_name":"Shinohara, Yoshiaki","last_name":"Shinohara"},{"full_name":"Kato, Yuichiro","last_name":"Kato","first_name":"Yuichiro"},{"first_name":"Hiroyuki","last_name":"Sugiyama","full_name":"Sugiyama, Hiroyuki"},{"last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi"},{"last_name":"Ito","full_name":"Ito, Isao","first_name":"Isao"}],"pmid":1,"date_published":"2003-05-09T00:00:00Z","doi":"10.1126/science.1082609","article_processing_charge":"No","title":"Asymmetrical allocation of NMDA receptor ε2 subunits in hippocampal circuitry","language":[{"iso":"eng"}],"OA_type":"closed access","type":"report","_id":"2627","status":"public","oa_version":"None","intvolume":"       300","month":"05"},{"language":[{"iso":"eng"}],"title":"Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes","article_processing_charge":"No","date_published":"2003-04-11T00:00:00Z","pmid":1,"intvolume":"       300","_id":"4255","type":"journal_article","publication_identifier":{"issn":["0036-8075"]},"year":"2003","date_updated":"2024-02-26T13:37:51Z","date_created":"2018-12-11T12:07:53Z","publication":"Science","abstract":[{"text":"Humans and their closest evolutionary relatives, the chimpanzees, differ in ∼1.24% of their genomic DNA sequences. The fraction of these changes accumulated during the speciation processes that have separated the two lineages may be of special relevance in understanding the basis of their differences. We analyzed human and chimpanzee sequence data to search for the patterns of divergence and polymorphism predicted by a theoretical model of speciation. According to the model, positively selected changes should accumulate in chromosomes that present fixed structural differences, such as inversions, between the two species. Protein evolution was more than 2.2 times faster in chromosomes that had undergone structural rearrangements compared with colinear chromosomes. Also, nucleotide variability is slightly lower in rearranged chromosomes. These patterns of divergence and polymorphism may be, at least in part, the molecular footprint of speciation events in the human and chimpanzee lineages. ","lang":"eng"}],"external_id":{"pmid":[" 12690198"]},"extern":"1","publist_id":"1841","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","quality_controlled":"1","doi":"10.1126/science.1080600 ","article_type":"original","month":"04","oa_version":"None","status":"public","issue":"5617","citation":{"ieee":"A. Navarro and N. H. Barton, “Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes,” <i>Science</i>, vol. 300, no. 5617. American Association for the Advancement of Science, pp. 321–324, 2003.","short":"A. Navarro, N.H. Barton, Science 300 (2003) 321–324.","apa":"Navarro, A., &#38; Barton, N. H. (2003). Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1080600 \">https://doi.org/10.1126/science.1080600 </a>","ista":"Navarro A, Barton NH. 2003. Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes. Science. 300(5617), 321–324.","chicago":"Navarro, Arcadio, and Nicholas H Barton. “Chromosomal Speciation and Molecular Divergence -- Accelerated Evolution in Rearranged Chromosomes.” <i>Science</i>. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1080600 \">https://doi.org/10.1126/science.1080600 </a>.","mla":"Navarro, Arcadio, and Nicholas H. Barton. “Chromosomal Speciation and Molecular Divergence -- Accelerated Evolution in Rearranged Chromosomes.” <i>Science</i>, vol. 300, no. 5617, American Association for the Advancement of Science, 2003, pp. 321–24, doi:<a href=\"https://doi.org/10.1126/science.1080600 \">10.1126/science.1080600 </a>.","ama":"Navarro A, Barton NH. Chromosomal speciation and molecular divergence -- Accelerated evolution in rearranged chromosomes. <i>Science</i>. 2003;300(5617):321-324. doi:<a href=\"https://doi.org/10.1126/science.1080600 \">10.1126/science.1080600 </a>"},"publication_status":"published","page":"321 - 324","scopus_import":"1","author":[{"full_name":"Navarro, Arcadio","last_name":"Navarro","first_name":"Arcadio"},{"last_name":"Barton","full_name":"Barton, Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","first_name":"Nicholas H"}],"day":"11","publisher":"American Association for the Advancement of Science","volume":300},{"type":"journal_article","_id":"9455","intvolume":"       299","title":"ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation","article_processing_charge":"No","date_published":"2003-01-31T00:00:00Z","pmid":1,"language":[{"iso":"eng"}],"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","department":[{"_id":"DaZi"}],"extern":"1","abstract":[{"lang":"eng","text":"Proteins of the ARGONAUTE family are important in diverse posttranscriptional RNA-mediated gene-silencing systems as well as in transcriptional gene silencing in Drosophila and fission yeast and in programmed DNA elimination in Tetrahymena. We cloned ARGONAUTE4 (AGO4) from a screen for mutants that suppress silencing of the Arabidopsis SUPERMAN(SUP) gene. The ago4-1 mutant reactivated silentSUP alleles and decreased CpNpG and asymmetric DNA methylation as well as histone H3 lysine-9 methylation. In addition,ago4-1 blocked histone and DNA methylation and the accumulation of 25-nucleotide small interfering RNAs (siRNAs) that correspond to the retroelement AtSN1. These results suggest that AGO4 and long siRNAs direct chromatin modifications, including histone methylation and non-CpG DNA methylation."}],"external_id":{"pmid":["12522258"]},"publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"date_updated":"2021-12-14T08:43:30Z","year":"2003","publication":"Science","date_created":"2021-06-04T11:26:26Z","status":"public","keyword":["Multidisciplinary"],"issue":"5607","article_type":"original","month":"01","oa_version":"None","doi":"10.1126/science.1079695","quality_controlled":"1","publisher":"American Association for the Advancement of Science","volume":299,"author":[{"last_name":"Zilberman","full_name":"Zilberman, Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","first_name":"Daniel","orcid":"0000-0002-0123-8649"},{"full_name":"Cao,  Xiaofeng","last_name":"Cao","first_name":" Xiaofeng"},{"last_name":"Jacobsen","full_name":"Jacobsen, Steven E.","first_name":"Steven E."}],"day":"31","scopus_import":"1","citation":{"short":"D. Zilberman,  Xiaofeng Cao, S.E. Jacobsen, Science 299 (2003) 716–719.","apa":"Zilberman, D., Cao,  Xiaofeng, &#38; Jacobsen, S. E. (2003). ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1079695\">https://doi.org/10.1126/science.1079695</a>","ama":"Zilberman D, Cao  Xiaofeng, Jacobsen SE. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. <i>Science</i>. 2003;299(5607):716-719. doi:<a href=\"https://doi.org/10.1126/science.1079695\">10.1126/science.1079695</a>","mla":"Zilberman, Daniel, et al. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>, vol. 299, no. 5607, American Association for the Advancement of Science, 2003, pp. 716–19, doi:<a href=\"https://doi.org/10.1126/science.1079695\">10.1126/science.1079695</a>.","ista":"Zilberman D, Cao  Xiaofeng, Jacobsen SE. 2003. ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation. Science. 299(5607), 716–719.","chicago":"Zilberman, Daniel,  Xiaofeng Cao, and Steven E. Jacobsen. “ARGONAUTE4 Control of Locus-Specific SiRNA Accumulation and DNA and Histone Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2003. <a href=\"https://doi.org/10.1126/science.1079695\">https://doi.org/10.1126/science.1079695</a>.","ieee":"D. Zilberman,  Xiaofeng Cao, and S. E. Jacobsen, “ARGONAUTE4 control of locus-specific siRNA accumulation and DNA and histone methylation,” <i>Science</i>, vol. 299, no. 5607. American Association for the Advancement of Science, pp. 716–719, 2003."},"page":"716-719","publication_status":"published"},{"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"2471","extern":"1","external_id":{"pmid":["12029133"]},"abstract":[{"text":"A central problem in biology is determining how genes interact as parts of functional networks. Creation and analysis of synthetic networks, composed of well-characterized genetic elements, provide a framework for theoretical modeling. Here, with the use of a combinatorial method, a library of networks with varying connectivity was generated in Escherichia coli. These networks were composed of genes encoding the transcriptional regulators Lacl, TetR, and lambda Cl, as well as the corresponding promoters. They displayed phenotypic behaviors resembling binary logical circuits, with two chemical “inputs” and a fluorescent protein “output.” Within this simple system, diverse computational functions arose through changes in network connectivity. Combinatorial synthesis provides an alternative approach for studying biological networks, as well as an efficient method for producing diverse phenotypes in vivo.","lang":"eng"}],"publication":"Science","date_created":"2018-12-11T12:05:00Z","date_updated":"2023-07-11T12:48:53Z","year":"2002","publication_identifier":{"issn":["0036-8075"]},"_id":"3757","type":"journal_article","intvolume":"       296","pmid":1,"date_published":"2002-05-24T00:00:00Z","title":"Combinatorial synthesis of genetic networks","article_processing_charge":"No","language":[{"iso":"eng"}],"volume":296,"publisher":"American Association for the Advancement of Science","day":"24","author":[{"first_name":"Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","last_name":"Guet"},{"last_name":"Elowitz","full_name":"Elowitz, Michael","first_name":"Michael"},{"last_name":"Hsing","full_name":"Hsing, Weihong","first_name":"Weihong"},{"first_name":"Stanislas","full_name":"Leibler, Stanislas","last_name":"Leibler"}],"scopus_import":"1","page":"1466 - 1470","publication_status":"published","citation":{"apa":"Guet, C. C., Elowitz, M., Hsing, W., &#38; Leibler, S. (2002). Combinatorial synthesis of genetic networks. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1067407\">https://doi.org/10.1126/science.1067407</a>","short":"C.C. Guet, M. Elowitz, W. Hsing, S. Leibler, Science 296 (2002) 1466–1470.","ista":"Guet CC, Elowitz M, Hsing W, Leibler S. 2002. Combinatorial synthesis of genetic networks. Science. 296(5572), 1466–1470.","chicago":"Guet, Calin C, Michael Elowitz, Weihong Hsing, and Stanislas Leibler. “Combinatorial Synthesis of Genetic Networks.” <i>Science</i>. American Association for the Advancement of Science, 2002. <a href=\"https://doi.org/10.1126/science.1067407\">https://doi.org/10.1126/science.1067407</a>.","ama":"Guet CC, Elowitz M, Hsing W, Leibler S. Combinatorial synthesis of genetic networks. <i>Science</i>. 2002;296(5572):1466-1470. doi:<a href=\"https://doi.org/10.1126/science.1067407\">10.1126/science.1067407</a>","mla":"Guet, Calin C., et al. “Combinatorial Synthesis of Genetic Networks.” <i>Science</i>, vol. 296, no. 5572, American Association for the Advancement of Science, 2002, pp. 1466–70, doi:<a href=\"https://doi.org/10.1126/science.1067407\">10.1126/science.1067407</a>.","ieee":"C. C. Guet, M. Elowitz, W. Hsing, and S. Leibler, “Combinatorial synthesis of genetic networks,” <i>Science</i>, vol. 296, no. 5572. American Association for the Advancement of Science, pp. 1466–1470, 2002."},"issue":"5572","status":"public","oa_version":"None","month":"05","article_type":"original","doi":"10.1126/science.1067407","quality_controlled":"1"},{"oa_version":"None","month":"12","issue":"5550","status":"public","quality_controlled":"1","doi":"10.1126/science.1065889","day":"14","author":[{"first_name":"John","last_name":"Huelsenbeck","full_name":"Huelsenbeck, John"},{"full_name":"Ronquist, Fredrik","last_name":"Ronquist","first_name":"Fredrik"},{"last_name":"Nielsen","full_name":"Nielsen, Rasmus","first_name":"Rasmus"},{"full_name":"Bollback, Jonathan P","last_name":"Bollback","orcid":"0000-0002-4624-4612","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","first_name":"Jonathan P"}],"volume":294,"publisher":"American Association for the Advancement of Science","page":"2310 - 2314","publication_status":"published","citation":{"ieee":"J. Huelsenbeck, F. Ronquist, R. Nielsen, and J. P. Bollback, “Bayesian inference of phylogeny and its impact on evolutionary biology,” <i>Science</i>, vol. 294, no. 5550. American Association for the Advancement of Science, pp. 2310–2314, 2001.","chicago":"Huelsenbeck, John, Fredrik Ronquist, Rasmus Nielsen, and Jonathan P Bollback. “Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology.” <i>Science</i>. American Association for the Advancement of Science, 2001. <a href=\"https://doi.org/10.1126/science.1065889\">https://doi.org/10.1126/science.1065889</a>.","mla":"Huelsenbeck, John, et al. “Bayesian Inference of Phylogeny and Its Impact on Evolutionary Biology.” <i>Science</i>, vol. 294, no. 5550, American Association for the Advancement of Science, 2001, pp. 2310–14, doi:<a href=\"https://doi.org/10.1126/science.1065889\">10.1126/science.1065889</a>.","ama":"Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. Bayesian inference of phylogeny and its impact on evolutionary biology. <i>Science</i>. 2001;294(5550):2310-2314. doi:<a href=\"https://doi.org/10.1126/science.1065889\">10.1126/science.1065889</a>","ista":"Huelsenbeck J, Ronquist F, Nielsen R, Bollback JP. 2001. Bayesian inference of phylogeny and its impact on evolutionary biology. Science. 294(5550), 2310–2314.","short":"J. Huelsenbeck, F. Ronquist, R. Nielsen, J.P. Bollback, Science 294 (2001) 2310–2314.","apa":"Huelsenbeck, J., Ronquist, F., Nielsen, R., &#38; Bollback, J. P. (2001). Bayesian inference of phylogeny and its impact on evolutionary biology. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1065889\">https://doi.org/10.1126/science.1065889</a>"},"intvolume":"       294","type":"journal_article","_id":"3438","language":[{"iso":"eng"}],"pmid":1,"date_published":"2001-12-14T00:00:00Z","article_processing_charge":"No","title":"Bayesian inference of phylogeny and its impact on evolutionary biology","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"2962","date_created":"2018-12-11T12:03:20Z","publication":"Science","date_updated":"2023-05-15T14:10:13Z","year":"2001","publication_identifier":{"issn":["0036-8075"]},"external_id":{"pmid":["11743192 "]},"abstract":[{"text":"As a discipline, phylogenetics is becoming transformed by a flood of molecular data. These data allow broad questions to be asked about the history of life, but also present difficult statistical and computational problems. Bayesian inference of phylogeny brings a new perspective to a number of outstanding issues in evolutionary biology, including the analysis of large phylogenetic trees and complex evolutionary models and the detection of the footprint of natural selection in DNA sequences.","lang":"eng"}]},{"doi":"10.1126/science.1059745","quality_controlled":"1","keyword":["Multidisciplinary"],"issue":"5524","status":"public","oa_version":"None","article_type":"original","month":"06","scopus_import":"1","page":"2077-2080","publication_status":"published","citation":{"ista":"Lindroth AM, Cao X, Jackson JP, Zilberman D, McCallum CM, Henikoff S, Jacobsen SE. 2001. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. Science. 292(5524), 2077–2080.","chicago":"Lindroth, A. M., Xiaofeng Cao, James P. Jackson, Daniel Zilberman, Claire M. McCallum, Steven Henikoff, and Steven E. Jacobsen. “Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation.” <i>Science</i>. American Association for the Advancement of Science, 2001. <a href=\"https://doi.org/10.1126/science.1059745\">https://doi.org/10.1126/science.1059745</a>.","mla":"Lindroth, A. M., et al. “Requirement of CHROMOMETHYLASE3 for Maintenance of CpXpG Methylation.” <i>Science</i>, vol. 292, no. 5524, American Association for the Advancement of Science, 2001, pp. 2077–80, doi:<a href=\"https://doi.org/10.1126/science.1059745\">10.1126/science.1059745</a>.","ama":"Lindroth AM, Cao X, Jackson JP, et al. Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. <i>Science</i>. 2001;292(5524):2077-2080. doi:<a href=\"https://doi.org/10.1126/science.1059745\">10.1126/science.1059745</a>","apa":"Lindroth, A. M., Cao, X., Jackson, J. P., Zilberman, D., McCallum, C. M., Henikoff, S., &#38; Jacobsen, S. E. (2001). Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.1059745\">https://doi.org/10.1126/science.1059745</a>","short":"A.M. Lindroth, X. Cao, J.P. Jackson, D. Zilberman, C.M. McCallum, S. Henikoff, S.E. Jacobsen, Science 292 (2001) 2077–2080.","ieee":"A. M. Lindroth <i>et al.</i>, “Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation,” <i>Science</i>, vol. 292, no. 5524. American Association for the Advancement of Science, pp. 2077–2080, 2001."},"volume":292,"publisher":"American Association for the Advancement of Science","day":"15","author":[{"first_name":"A. M.","full_name":"Lindroth, A. M.","last_name":"Lindroth"},{"first_name":"Xiaofeng","last_name":"Cao","full_name":"Cao, Xiaofeng"},{"first_name":"James P.","full_name":"Jackson, James P.","last_name":"Jackson"},{"last_name":"Zilberman","full_name":"Zilberman, Daniel","first_name":"Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","orcid":"0000-0002-0123-8649"},{"full_name":"McCallum, Claire M.","last_name":"McCallum","first_name":"Claire M."},{"first_name":"Steven","full_name":"Henikoff, Steven","last_name":"Henikoff"},{"first_name":"Steven E.","full_name":"Jacobsen, Steven E.","last_name":"Jacobsen"}],"date_published":"2001-06-15T00:00:00Z","pmid":1,"title":"Requirement of CHROMOMETHYLASE3 for maintenance of CpXpG methylation","article_processing_charge":"No","language":[{"iso":"eng"}],"_id":"9444","type":"journal_article","intvolume":"       292","external_id":{"pmid":["11349138"]},"abstract":[{"text":"Epigenetic silenced alleles of the Arabidopsis SUPERMANlocus (the clark kent alleles) are associated with dense hypermethylation at noncanonical cytosines (CpXpG and asymmetric sites, where X = A, T, C, or G). A genetic screen for suppressors of a hypermethylated clark kent mutant identified nine loss-of-function alleles of CHROMOMETHYLASE3(CMT3), a novel cytosine methyltransferase homolog. These cmt3 mutants display a wild-type morphology but exhibit decreased CpXpG methylation of the SUP gene and of other sequences throughout the genome. They also show reactivated expression of endogenous retrotransposon sequences. These results show that a non-CpG DNA methyltransferase is responsible for maintaining epigenetic gene silencing.","lang":"eng"}],"year":"2001","date_updated":"2021-12-14T08:40:32Z","date_created":"2021-06-02T13:35:16Z","publication":"Science","publication_identifier":{"issn":["0036-8075"],"eissn":["1095-9203"]},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","department":[{"_id":"DaZi"}],"extern":"1"},{"language":[{"iso":"eng"}],"date_published":"2000-06-09T00:00:00Z","pmid":1,"article_processing_charge":"No","title":"mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination","intvolume":"       288","type":"journal_article","_id":"2601","date_updated":"2023-05-03T09:53:38Z","year":"2000","date_created":"2018-12-11T11:58:36Z","publication":"Science","publication_identifier":{"issn":["0036-8075"]},"external_id":{"pmid":["10846166 "]},"abstract":[{"text":"Targeted deletion of metabotropic glutamate receptor-subtype 1 (mGluR1) gene can cause defects in development and function in the cerebellum. We introduced the mGluR1α transgene into mGluR1-null mutant [mGluR1 (-/-)] mice with a Purkinje cell (PC)-specific promoter. mGluR1-rescue mice showed normal cerebellar long-term depression and regression of multiple climbing fiber innervation, events significantly impaired in mGluR1 (-/-) mice. The impaired motor coordination was rescued by this transgene, in a dose-dependent manner. We propose that mGluR1 in PCs is a key molecule for normal synapse formation, synaptic plasticity, and motor control in the cerebellum.","lang":"eng"}],"extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4297","quality_controlled":"1","doi":"10.1126/science.288.5472.1832","oa_version":"None","article_type":"original","month":"06","issue":"5472","status":"public","page":"1832 - 1835","publication_status":"published","citation":{"ieee":"T. Ichise <i>et al.</i>, “mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination,” <i>Science</i>, vol. 288, no. 5472. American Association for the Advancement of Science, pp. 1832–1835, 2000.","ista":"Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, Shigemoto R, Katsuki M, Aiba A. 2000. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science. 288(5472), 1832–1835.","chicago":"Ichise, Taeko, Masanobu Kano, Kouichi Hashimoto, Dai Yanagihara, Kazuki Nakao, Ryuichi Shigemoto, Motoya Katsuki, and Atsu Aiba. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” <i>Science</i>. American Association for the Advancement of Science, 2000. <a href=\"https://doi.org/10.1126/science.288.5472.1832\">https://doi.org/10.1126/science.288.5472.1832</a>.","mla":"Ichise, Taeko, et al. “MGluR1 in Cerebellar Purkinje Cells Essential for Long-Term Depression, Synapse Elimination, and Motor Coordination.” <i>Science</i>, vol. 288, no. 5472, American Association for the Advancement of Science, 2000, pp. 1832–35, doi:<a href=\"https://doi.org/10.1126/science.288.5472.1832\">10.1126/science.288.5472.1832</a>.","ama":"Ichise T, Kano M, Hashimoto K, et al. mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. <i>Science</i>. 2000;288(5472):1832-1835. doi:<a href=\"https://doi.org/10.1126/science.288.5472.1832\">10.1126/science.288.5472.1832</a>","apa":"Ichise, T., Kano, M., Hashimoto, K., Yanagihara, D., Nakao, K., Shigemoto, R., … Aiba, A. (2000). mGluR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.288.5472.1832\">https://doi.org/10.1126/science.288.5472.1832</a>","short":"T. Ichise, M. Kano, K. Hashimoto, D. Yanagihara, K. Nakao, R. Shigemoto, M. Katsuki, A. Aiba, Science 288 (2000) 1832–1835."},"scopus_import":"1","day":"09","author":[{"last_name":"Ichise","full_name":"Ichise, Taeko","first_name":"Taeko"},{"first_name":"Masanobu","full_name":"Kano, Masanobu","last_name":"Kano"},{"first_name":"Kouichi","last_name":"Hashimoto","full_name":"Hashimoto, Kouichi"},{"first_name":"Dai","last_name":"Yanagihara","full_name":"Yanagihara, Dai"},{"last_name":"Nakao","full_name":"Nakao, Kazuki","first_name":"Kazuki"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"first_name":"Motoya","full_name":"Katsuki, Motoya","last_name":"Katsuki"},{"last_name":"Aiba","full_name":"Aiba, Atsu","first_name":"Atsu"}],"volume":288,"publisher":"American Association for the Advancement of Science"},{"publist_id":"2896","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","extern":"1","abstract":[{"text":"Fast and reliable activation of inhibitory interneurons is critical for the stability of cortical neuronal networks. Active conductances in dendrites may facilitate interneuron activation, but direct experimental evidence was unavailable. Patch-clamp recordings from dendrites of hippocampal oriens- alveus interneurons revealed high densities of voltage-gated sodium and potassium ion channels. Simultaneous recordings from dendrites and somata suggested that action potential initiation occurs preferentially in the axon with long threshold stimuli, but can be shifted to somatodendritic sites when brief stimuli are applied. After initiation, action potentials propagate over the somatodendritic domain with constant amplitude, high velocity, and reliability, even during high-frequency trains.","lang":"eng"}],"external_id":{"pmid":["10634782"]},"publication_identifier":{"issn":["0036-8075"]},"year":"2000","date_updated":"2023-05-03T07:55:32Z","publication":"Science","date_created":"2018-12-11T12:03:36Z","_id":"3491","type":"journal_article","intvolume":"       287","article_processing_charge":"No","title":"Distal initiation and active propagation of action potentials in interneuron dendrites","date_published":"2000-01-14T00:00:00Z","pmid":1,"language":[{"iso":"eng"}],"publisher":"American Association for the Advancement of Science","volume":287,"author":[{"first_name":"Marco","last_name":"Martina","full_name":"Martina, Marco"},{"first_name":"Imre","full_name":"Vida, Imre","last_name":"Vida"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas","full_name":"Jonas, Peter M"}],"day":"14","scopus_import":"1","citation":{"short":"M. Martina, I. Vida, P.M. Jonas, Science 287 (2000) 295–300.","apa":"Martina, M., Vida, I., &#38; Jonas, P. M. (2000). Distal initiation and active propagation of action potentials in interneuron dendrites. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.287.5451.295\">https://doi.org/10.1126/science.287.5451.295</a>","ista":"Martina M, Vida I, Jonas PM. 2000. Distal initiation and active propagation of action potentials in interneuron dendrites. Science. 287(5451), 295–300.","mla":"Martina, Marco, et al. “Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites.” <i>Science</i>, vol. 287, no. 5451, American Association for the Advancement of Science, 2000, pp. 295–300, doi:<a href=\"https://doi.org/10.1126/science.287.5451.295\">10.1126/science.287.5451.295</a>.","chicago":"Martina, Marco, Imre Vida, and Peter M Jonas. “Distal Initiation and Active Propagation of Action Potentials in Interneuron Dendrites.” <i>Science</i>. American Association for the Advancement of Science, 2000. <a href=\"https://doi.org/10.1126/science.287.5451.295\">https://doi.org/10.1126/science.287.5451.295</a>.","ama":"Martina M, Vida I, Jonas PM. Distal initiation and active propagation of action potentials in interneuron dendrites. <i>Science</i>. 2000;287(5451):295-300. doi:<a href=\"https://doi.org/10.1126/science.287.5451.295\">10.1126/science.287.5451.295</a>","ieee":"M. Martina, I. Vida, and P. M. Jonas, “Distal initiation and active propagation of action potentials in interneuron dendrites,” <i>Science</i>, vol. 287, no. 5451. American Association for the Advancement of Science, pp. 295–300, 2000."},"page":"295 - 300","publication_status":"published","status":"public","issue":"5451","article_type":"original","month":"01","oa_version":"None","quality_controlled":"1","doi":"10.1126/science.287.5451.295"},{"intvolume":"       281","_id":"3487","type":"journal_article","language":[{"iso":"eng"}],"date_published":"1998-07-17T00:00:00Z","pmid":1,"title":"Corelease of two fast neurotransmitters at a central synapse","article_processing_charge":"No","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"2900","date_updated":"2022-08-29T14:52:38Z","year":"1998","publication":"Science","date_created":"2018-12-11T12:03:35Z","acknowledgement":"See comment by Nicoll RA, Malenka RC (1998) Science 281:360-361\r\n","publication_identifier":{"issn":["0036-8075"]},"external_id":{"pmid":["9665886 "]},"abstract":[{"text":"It is widely accepted that individual neurons in the central nervous system release only a single fast transmitter. The possibility of corelease of fast neurotransmitters was examined by making paired recordings from synaptically connected neurons in spinal cord slices. Unitary inhibitory postsynaptic currents generated at interneuron-motoneuron synapses consisted of a strychnine-sensitive, glycine receptor-mediated component and a bicuculline-sensitive, γ-aminobutyric acid (GABA)(A) receptor-mediated component. These results indicate that spinal interneurons release both glycine and GABA to activate functionally distinct receptors in their postsynaptic target cells. A subset of miniature synaptic currents also showed both components, consistent with corelease from individual synaptic vesicles.","lang":"eng"}],"oa_version":"None","article_type":"original","month":"07","issue":"5375","status":"public","doi":"10.1126/science.281.5375.419","quality_controlled":"1","day":"17","author":[{"full_name":"Jonas, Peter M","last_name":"Jonas","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Joseph","full_name":"Bischofberger, Joseph","last_name":"Bischofberger"},{"first_name":"Jürgen","full_name":"Sandkühler, Jürgen","last_name":"Sandkühler"}],"volume":281,"publisher":"American Association for the Advancement of Science","page":"419 - 424","publication_status":"published","citation":{"ama":"Jonas PM, Bischofberger J, Sandkühler J. Corelease of two fast neurotransmitters at a central synapse. <i>Science</i>. 1998;281(5375):419-424. doi:<a href=\"https://doi.org/10.1126/science.281.5375.419\">10.1126/science.281.5375.419</a>","mla":"Jonas, Peter M., et al. “Corelease of Two Fast Neurotransmitters at a Central Synapse.” <i>Science</i>, vol. 281, no. 5375, American Association for the Advancement of Science, 1998, pp. 419–24, doi:<a href=\"https://doi.org/10.1126/science.281.5375.419\">10.1126/science.281.5375.419</a>.","ista":"Jonas PM, Bischofberger J, Sandkühler J. 1998. Corelease of two fast neurotransmitters at a central synapse. Science. 281(5375), 419–424.","chicago":"Jonas, Peter M, Joseph Bischofberger, and Jürgen Sandkühler. “Corelease of Two Fast Neurotransmitters at a Central Synapse.” <i>Science</i>. American Association for the Advancement of Science, 1998. <a href=\"https://doi.org/10.1126/science.281.5375.419\">https://doi.org/10.1126/science.281.5375.419</a>.","apa":"Jonas, P. M., Bischofberger, J., &#38; Sandkühler, J. (1998). Corelease of two fast neurotransmitters at a central synapse. <i>Science</i>. American Association for the Advancement of Science. <a href=\"https://doi.org/10.1126/science.281.5375.419\">https://doi.org/10.1126/science.281.5375.419</a>","short":"P.M. Jonas, J. Bischofberger, J. Sandkühler, Science 281 (1998) 419–424.","ieee":"P. M. Jonas, J. Bischofberger, and J. Sandkühler, “Corelease of two fast neurotransmitters at a central synapse,” <i>Science</i>, vol. 281, no. 5375. American Association for the Advancement of Science, pp. 419–424, 1998."},"scopus_import":"1"}]