@article{22974,
  abstract     = {Far from being static structures, it is now well accepted that proteins are highly dynamic entities even in the solid state. Here, we review recent progress in application of magic-angle spinning (MAS) NMR for studying the site-specific dynamics of proteins, as assessed using spin-relaxation and measurement of anisotropic spin interactions. We focus on the types of experimental data that are available, and how best to access the information which is provided by these experimental measurements; in particular, we provide a retrospective on the field in light of recent advances in analytical methodologies, which have led to a slow paradigm shift in how we interpret relaxation rate constant measurements made in the solid state.},
  author       = {Tatman, Benjamin and Schanda, Paul},
  issn         = {1873-3301},
  journal      = {Progress in Nuclear Magnetic Resonance Spectroscopy},
  keywords     = {Solid-state NMR, Protein dynamics, Magic-angle spinning},
  publisher    = {Elsevier},
  title        = {{Quantifying fast protein dynamics by magic-angle spinning NMR: Progress in experimental and analytical approaches}},
  doi          = {10.1016/j.pnmrs.2026.101615},
  volume       = {156-157},
  year         = {2026},
}

@article{8454,
  abstract     = {Magic-angle spinning solid-state NMR spectroscopy is an important technique to study molecular structure, dynamics and interactions, and is rapidly gaining importance in biomolecular sciences. Here we provide an overview of experimental approaches to study molecular dynamics by MAS solid-state NMR, with an emphasis on the underlying theoretical concepts and differences of MAS solid-state NMR compared to solution-state NMR. The theoretical foundations of nuclear spin relaxation are revisited, focusing on the particularities of spin relaxation in solid samples under magic-angle spinning. We discuss the range of validity of Redfield theory, as well as the inherent multi-exponential behavior of relaxation in solids. Experimental challenges for measuring relaxation parameters in MAS solid-state NMR and a few recently proposed relaxation approaches are discussed, which provide information about time scales and amplitudes of motions ranging from picoseconds to milliseconds. We also discuss the theoretical basis and experimental measurements of anisotropic interactions (chemical-shift anisotropies, dipolar and quadrupolar couplings), which give direct information about the amplitude of motions. The potential of combining relaxation data with such measurements of dynamically-averaged anisotropic interactions is discussed. Although the focus of this review is on the theoretical foundations of dynamics studies rather than their application, we close by discussing a small number of recent dynamics studies, where the dynamic properties of proteins in crystals are compared to those in solution.},
  author       = {Schanda, Paul and Ernst, Matthias},
  issn         = {0079-6565},
  journal      = {Progress in Nuclear Magnetic Resonance Spectroscopy},
  number       = {8},
  pages        = {1--46},
  publisher    = {Elsevier},
  title        = {{Studying dynamics by magic-angle spinning solid-state NMR spectroscopy: Principles and applications to biomolecules}},
  doi          = {10.1016/j.pnmrs.2016.02.001},
  volume       = {96},
  year         = {2016},
}

@article{8475,
  author       = {Schanda, Paul},
  issn         = {0079-6565},
  journal      = {Progress in Nuclear Magnetic Resonance Spectroscopy},
  number       = {3},
  pages        = {238--265},
  publisher    = {Elsevier},
  title        = {{Fast-pulsing longitudinal relaxation optimized techniques: Enriching the toolbox of fast biomolecular NMR spectroscopy}},
  doi          = {10.1016/j.pnmrs.2009.05.002},
  volume       = {55},
  year         = {2009},
}