@article{9535,
  abstract     = {The most well-studied function of DNA methylation in eukaryotic cells is the transcriptional silencing of genes and transposons. More recent results showed that many eukaryotes methylate the bodies of genes as well and that this methylation correlates with transcriptional activity rather than repression. The purpose of gene body methylation remains mysterious, but is potentially related to the histone variant H2A.Z. Studies in plants and animals have shown that the genome-wide distributions of H2A.Z and DNA methylation are strikingly anticorrelated. Furthermore, we and other investigators have shown that this relationship is likely to be the result of an ancient but unknown mechanism by which DNA methylation prevents the incorporation of H2A.Z. Recently, we discovered strong correlations between the presence of H2A.Z within gene bodies, the degree to which a gene's expression varies across tissue types or environmental conditions, and transcriptional misregulation in an h2a.z mutant. We propose that one basal function of gene body methylation is the establishment of constitutive expression patterns within housekeeping genes by excluding H2A.Z from their bodies.},
  author       = {Coleman-Derr, D. and Zilberman, Daniel},
  issn         = {1943-4456},
  journal      = {Cold Spring Harbor Symposia on Quantitative Biology},
  pages        = {147--154},
  publisher    = {Cold Spring Harbor Laboratory Press},
  title        = {{DNA methylation, H2A.Z, and the regulation of constitutive expression}},
  doi          = {10.1101/sqb.2012.77.014944},
  volume       = {77},
  year         = {2012},
}

@article{11100,
  abstract     = {Eukaryotic cell function depends on the physical separation of nucleoplasmic and cytoplasmic components by the nuclear envelope (NE). Molecular communication between the two compartments involves active, signal-mediated trafficking, a function that is exclusively performed by nuclear pore complexes (NPCs). The individual NPC components and the mechanisms that are involved in nuclear trafficking are well documented and have become textbook knowledge. However, in addition to their roles as nuclear gatekeepers, NPC components-nucleoporins-have been shown to have critical roles in chromatin organization and gene regulation. These findings have sparked new enthusiasm to study the roles of this multiprotein complex in nuclear organization and explore novel functions that in some cases appear to go beyond a role in transport. Here, we discuss our present view of NPC biogenesis, which is tightly linked to proper cell cycle progression and cell differentiation. In addition, we summarize new data suggesting that NPCs represent dynamic hubs for the integration of gene regulation and nuclear transport processes.},
  author       = {Capelson, M. and Doucet, C. and HETZER, Martin W},
  isbn         = {9781936113071},
  issn         = {0091-7451},
  journal      = {Cold Spring Harbor Symposia on Quantitative Biology},
  keywords     = {Genetics, Molecular Biology, Biochemistry},
  pages        = {585--597},
  publisher    = {Cold Spring Harbor Laboratory Press},
  title        = {{Nuclear pore complexes: Guardians of the nuclear genome}},
  doi          = {10.1101/sqb.2010.75.059},
  volume       = {75},
  year         = {2011},
}