---
_id: '9535'
abstract:
- lang: eng
  text: The most well-studied function of DNA methylation in eukaryotic cells is the
    transcriptional silencing of genes and transposons. More recent results showed
    that many eukaryotes methylate the bodies of genes as well and that this methylation
    correlates with transcriptional activity rather than repression. The purpose of
    gene body methylation remains mysterious, but is potentially related to the histone
    variant H2A.Z. Studies in plants and animals have shown that the genome-wide distributions
    of H2A.Z and DNA methylation are strikingly anticorrelated. Furthermore, we and
    other investigators have shown that this relationship is likely to be the result
    of an ancient but unknown mechanism by which DNA methylation prevents the incorporation
    of H2A.Z. Recently, we discovered strong correlations between the presence of
    H2A.Z within gene bodies, the degree to which a gene's expression varies across
    tissue types or environmental conditions, and transcriptional misregulation in
    an h2a.z mutant. We propose that one basal function of gene body methylation is
    the establishment of constitutive expression patterns within housekeeping genes
    by excluding H2A.Z from their bodies.
article_processing_charge: No
article_type: review
author:
- first_name: D.
  full_name: Coleman-Derr, D.
  last_name: Coleman-Derr
- first_name: Daniel
  full_name: Zilberman, Daniel
  id: 6973db13-dd5f-11ea-814e-b3e5455e9ed1
  last_name: Zilberman
  orcid: 0000-0002-0123-8649
citation:
  ama: Coleman-Derr D, Zilberman D. DNA methylation, H2A.Z, and the regulation of
    constitutive expression. <i>Cold Spring Harbor Symposia on Quantitative Biology</i>.
    2012;77:147-154. doi:<a href="https://doi.org/10.1101/sqb.2012.77.014944">10.1101/sqb.2012.77.014944</a>
  apa: Coleman-Derr, D., &#38; Zilberman, D. (2012). DNA methylation, H2A.Z, and the
    regulation of constitutive expression. <i>Cold Spring Harbor Symposia on Quantitative
    Biology</i>. Cold Spring Harbor Laboratory Press. <a href="https://doi.org/10.1101/sqb.2012.77.014944">https://doi.org/10.1101/sqb.2012.77.014944</a>
  chicago: Coleman-Derr, D., and Daniel Zilberman. “DNA Methylation, H2A.Z, and the
    Regulation of Constitutive Expression.” <i>Cold Spring Harbor Symposia on Quantitative
    Biology</i>. Cold Spring Harbor Laboratory Press, 2012. <a href="https://doi.org/10.1101/sqb.2012.77.014944">https://doi.org/10.1101/sqb.2012.77.014944</a>.
  ieee: D. Coleman-Derr and D. Zilberman, “DNA methylation, H2A.Z, and the regulation
    of constitutive expression,” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>,
    vol. 77. Cold Spring Harbor Laboratory Press, pp. 147–154, 2012.
  ista: Coleman-Derr D, Zilberman D. 2012. DNA methylation, H2A.Z, and the regulation
    of constitutive expression. Cold Spring Harbor Symposia on Quantitative Biology.
    77, 147–154.
  mla: Coleman-Derr, D., and Daniel Zilberman. “DNA Methylation, H2A.Z, and the Regulation
    of Constitutive Expression.” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>,
    vol. 77, Cold Spring Harbor Laboratory Press, 2012, pp. 147–54, doi:<a href="https://doi.org/10.1101/sqb.2012.77.014944">10.1101/sqb.2012.77.014944</a>.
  short: D. Coleman-Derr, D. Zilberman, Cold Spring Harbor Symposia on Quantitative
    Biology 77 (2012) 147–154.
date_created: 2021-06-08T13:01:23Z
date_published: 2012-12-18T00:00:00Z
date_updated: 2021-12-14T08:33:09Z
day: '18'
department:
- _id: DaZi
doi: 10.1101/sqb.2012.77.014944
extern: '1'
external_id:
  pmid:
  - '23250988'
intvolume: '        77'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1101/sqb.2012.77.014944
month: '12'
oa: 1
oa_version: Published Version
page: 147-154
pmid: 1
publication: Cold Spring Harbor Symposia on Quantitative Biology
publication_identifier:
  eissn:
  - 1943-4456
  issn:
  - 0091-7451
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: DNA methylation, H2A.Z, and the regulation of constitutive expression
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 77
year: '2012'
...
---
_id: '11100'
abstract:
- lang: eng
  text: Eukaryotic cell function depends on the physical separation of nucleoplasmic
    and cytoplasmic components by the nuclear envelope (NE). Molecular communication
    between the two compartments involves active, signal-mediated trafficking, a function
    that is exclusively performed by nuclear pore complexes (NPCs). The individual
    NPC components and the mechanisms that are involved in nuclear trafficking are
    well documented and have become textbook knowledge. However, in addition to their
    roles as nuclear gatekeepers, NPC components-nucleoporins-have been shown to have
    critical roles in chromatin organization and gene regulation. These findings have
    sparked new enthusiasm to study the roles of this multiprotein complex in nuclear
    organization and explore novel functions that in some cases appear to go beyond
    a role in transport. Here, we discuss our present view of NPC biogenesis, which
    is tightly linked to proper cell cycle progression and cell differentiation. In
    addition, we summarize new data suggesting that NPCs represent dynamic hubs for
    the integration of gene regulation and nuclear transport processes.
article_processing_charge: No
article_type: original
author:
- first_name: M.
  full_name: Capelson, M.
  last_name: Capelson
- first_name: C.
  full_name: Doucet, C.
  last_name: Doucet
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: 'Capelson M, Doucet C, Hetzer M. Nuclear pore complexes: Guardians of the nuclear
    genome. <i>Cold Spring Harbor Symposia on Quantitative Biology</i>. 2011;75:585-597.
    doi:<a href="https://doi.org/10.1101/sqb.2010.75.059">10.1101/sqb.2010.75.059</a>'
  apa: 'Capelson, M., Doucet, C., &#38; Hetzer, M. (2011). Nuclear pore complexes:
    Guardians of the nuclear genome. <i>Cold Spring Harbor Symposia on Quantitative
    Biology</i>. Cold Spring Harbor Laboratory Press. <a href="https://doi.org/10.1101/sqb.2010.75.059">https://doi.org/10.1101/sqb.2010.75.059</a>'
  chicago: 'Capelson, M., C. Doucet, and Martin Hetzer. “Nuclear Pore Complexes: Guardians
    of the Nuclear Genome.” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>.
    Cold Spring Harbor Laboratory Press, 2011. <a href="https://doi.org/10.1101/sqb.2010.75.059">https://doi.org/10.1101/sqb.2010.75.059</a>.'
  ieee: 'M. Capelson, C. Doucet, and M. Hetzer, “Nuclear pore complexes: Guardians
    of the nuclear genome,” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>,
    vol. 75. Cold Spring Harbor Laboratory Press, pp. 585–597, 2011.'
  ista: 'Capelson M, Doucet C, Hetzer M. 2011. Nuclear pore complexes: Guardians of
    the nuclear genome. Cold Spring Harbor Symposia on Quantitative Biology. 75, 585–597.'
  mla: 'Capelson, M., et al. “Nuclear Pore Complexes: Guardians of the Nuclear Genome.”
    <i>Cold Spring Harbor Symposia on Quantitative Biology</i>, vol. 75, Cold Spring
    Harbor Laboratory Press, 2011, pp. 585–97, doi:<a href="https://doi.org/10.1101/sqb.2010.75.059">10.1101/sqb.2010.75.059</a>.'
  short: M. Capelson, C. Doucet, M. Hetzer, Cold Spring Harbor Symposia on Quantitative
    Biology 75 (2011) 585–597.
date_created: 2022-04-07T07:53:18Z
date_published: 2011-04-18T00:00:00Z
date_updated: 2024-10-14T11:27:48Z
day: '18'
doi: 10.1101/sqb.2010.75.059
extern: '1'
external_id:
  pmid:
  - '21502404'
intvolume: '        75'
keyword:
- Genetics
- Molecular Biology
- Biochemistry
language:
- iso: eng
month: '04'
oa_version: None
page: 585-597
pmid: 1
publication: Cold Spring Harbor Symposia on Quantitative Biology
publication_identifier:
  isbn:
  - '9781936113071'
  issn:
  - 0091-7451
  - 1943-4456
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Nuclear pore complexes: Guardians of the nuclear genome'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 75
year: '2011'
...