---
_id: '15099'
abstract:
- lang: eng
  text: Speciation is a key evolutionary process that is not yet fully understood.
    Combining population genomic and ecological data from multiple diverging pairs
    of marine snails (Littorina) supports the search for speciation mechanisms. Placing
    pairs on a one-dimensional speciation continuum, from undifferentiated populations
    to species, obscured the complexity of speciation. Adding multiple axes helped
    to describe either speciation routes or reproductive isolation in the snails.
    Divergent ecological selection repeatedly generated barriers between ecotypes,
    but appeared less important in completing speciation while genetic incompatibilities
    played a key role. Chromosomal inversions contributed to genomic barriers, but
    with variable impact. A multidimensional (hypercube) approach supported framing
    of questions and identification of knowledge gaps and can be useful to understand
    speciation in many other systems.
acknowledgement: KJ, MR, and RKB were supported by grants from the Swedish Research
  Council (2021-0419, 2021-05243, and 2018-03695, respectively). RKB was also supported
  by the Leverhulme Trust (RPG-2021-141), RF by FCT- Portuguese Science Foundation
  (PTDC/BIA-EVL/1614/2021 and 2020.00275.CEECIND), and AMW by Norwegian Research Council
  RCN (Project number 315287). We thank the members of the Integration of Speciation
  Research network for stimulating discussions, the Littorina research community for
  important contributions of data and analyses, and Cynthia Riginos for useful comments
  on an earlier draft.
article_processing_charge: Yes (in subscription journal)
article_type: review
author:
- first_name: Kerstin
  full_name: Johannesson, Kerstin
  last_name: Johannesson
- first_name: Rui
  full_name: Faria, Rui
  last_name: Faria
- first_name: Alan
  full_name: Le Moan, Alan
  last_name: Le Moan
- first_name: Marina
  full_name: Rafajlović, Marina
  last_name: Rafajlović
- first_name: Anja M
  full_name: Westram, Anja M
  id: 3C147470-F248-11E8-B48F-1D18A9856A87
  last_name: Westram
  orcid: 0000-0003-1050-4969
- first_name: Roger K.
  full_name: Butlin, Roger K.
  last_name: Butlin
- first_name: Sean
  full_name: Stankowski, Sean
  id: 43161670-5719-11EA-8025-FABC3DDC885E
  last_name: Stankowski
citation:
  ama: Johannesson K, Faria R, Le Moan A, et al. Diverse pathways to speciation revealed
    by marine snails. <i>Trends in Genetics</i>. 2024;40(4):337-351. doi:<a href="https://doi.org/10.1016/j.tig.2024.01.002">10.1016/j.tig.2024.01.002</a>
  apa: Johannesson, K., Faria, R., Le Moan, A., Rafajlović, M., Westram, A. M., Butlin,
    R. K., &#38; Stankowski, S. (2024). Diverse pathways to speciation revealed by
    marine snails. <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2024.01.002">https://doi.org/10.1016/j.tig.2024.01.002</a>
  chicago: Johannesson, Kerstin, Rui Faria, Alan Le Moan, Marina Rafajlović, Anja
    M Westram, Roger K. Butlin, and Sean Stankowski. “Diverse Pathways to Speciation
    Revealed by Marine Snails.” <i>Trends in Genetics</i>. Elsevier, 2024. <a href="https://doi.org/10.1016/j.tig.2024.01.002">https://doi.org/10.1016/j.tig.2024.01.002</a>.
  ieee: K. Johannesson <i>et al.</i>, “Diverse pathways to speciation revealed by
    marine snails,” <i>Trends in Genetics</i>, vol. 40, no. 4. Elsevier, pp. 337–351,
    2024.
  ista: Johannesson K, Faria R, Le Moan A, Rafajlović M, Westram AM, Butlin RK, Stankowski
    S. 2024. Diverse pathways to speciation revealed by marine snails. Trends in Genetics.
    40(4), 337–351.
  mla: Johannesson, Kerstin, et al. “Diverse Pathways to Speciation Revealed by Marine
    Snails.” <i>Trends in Genetics</i>, vol. 40, no. 4, Elsevier, 2024, pp. 337–51,
    doi:<a href="https://doi.org/10.1016/j.tig.2024.01.002">10.1016/j.tig.2024.01.002</a>.
  short: K. Johannesson, R. Faria, A. Le Moan, M. Rafajlović, A.M. Westram, R.K. Butlin,
    S. Stankowski, Trends in Genetics 40 (2024) 337–351.
date_created: 2024-03-10T23:00:54Z
date_published: 2024-04-01T00:00:00Z
date_updated: 2025-09-04T12:18:08Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1016/j.tig.2024.01.002
external_id:
  isi:
  - '001224671300001'
  pmid:
  - '38395682'
file:
- access_level: open_access
  checksum: 3077ea808c4cdc24d02dc58aced7eb35
  content_type: application/pdf
  creator: dernst
  date_created: 2024-07-22T12:05:58Z
  date_updated: 2024-07-22T12:05:58Z
  file_id: '17313'
  file_name: 2024_TrendsGenetics_Johannesson.pdf
  file_size: 2288340
  relation: main_file
  success: 1
file_date_updated: 2024-07-22T12:05:58Z
has_accepted_license: '1'
intvolume: '        40'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 337-351
pmid: 1
publication: Trends in Genetics
publication_identifier:
  eissn:
  - 1362-4555
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Diverse pathways to speciation revealed by marine snails
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 40
year: '2024'
...
---
OA_type: closed access
_id: '886'
abstract:
- lang: eng
  text: The factors that determine the tempo and mode of protein evolution continue
    to be a central question in molecular evolution. Traditionally, studies of protein
    evolution focused on the rates of amino acid substitutions. More recently, with
    the availability of sequence data and advanced experimental techniques, the focus
    of attention has shifted toward the study of evolutionary trajectories and the
    overall layout of protein fitness landscapes. In this review we describe the effect
    of epistasis on the topology of evolutionary pathways that are likely to be found
    in fitness landscapes and develop a simple theory to connect the number of maladapted
    genotypes to the topology of fitness landscapes with epistatic interactions. Finally,
    we review recent studies that have probed the extent of epistatic interactions
    and have begun to chart the fitness landscapes in protein sequence space.
acknowledgement: 'This work has been supported by a grant from the HHMI International
  Early Career Scientist Program (#55007424), the Spanish Ministry of Economy and
  Competitiveness (grant #BFU2012-31329) as part of the EMBO YIP program, two grants
  from the Spanish Ministry of Economy and Competitiveness, Centro de Excelencia Severo
  Ochoa 2013–2017 (#Sev-2012-0208) and BES-2013-064004 funded by the European Regional
  Development Fund (ERDF), the European Union, and the European Research Council under
  grant agreement no 335980_EinME.'
article_processing_charge: No
article_type: original
author:
- first_name: Dmitry
  full_name: Kondrashov, Dmitry
  last_name: Kondrashov
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
citation:
  ama: Kondrashov D, Kondrashov F. Topological features of rugged fitness landscapes
    in sequence space. <i>Trends in Genetics</i>. 2015;31(1):24-33. doi:<a href="https://doi.org/10.1016/j.tig.2014.09.009">10.1016/j.tig.2014.09.009</a>
  apa: Kondrashov, D., &#38; Kondrashov, F. (2015). Topological features of rugged
    fitness landscapes in sequence space. <i>Trends in Genetics</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.tig.2014.09.009">https://doi.org/10.1016/j.tig.2014.09.009</a>
  chicago: Kondrashov, Dmitry, and Fyodor Kondrashov. “Topological Features of Rugged
    Fitness Landscapes in Sequence Space.” <i>Trends in Genetics</i>. Elsevier, 2015.
    <a href="https://doi.org/10.1016/j.tig.2014.09.009">https://doi.org/10.1016/j.tig.2014.09.009</a>.
  ieee: D. Kondrashov and F. Kondrashov, “Topological features of rugged fitness landscapes
    in sequence space,” <i>Trends in Genetics</i>, vol. 31, no. 1. Elsevier, pp. 24–33,
    2015.
  ista: Kondrashov D, Kondrashov F. 2015. Topological features of rugged fitness landscapes
    in sequence space. Trends in Genetics. 31(1), 24–33.
  mla: Kondrashov, Dmitry, and Fyodor Kondrashov. “Topological Features of Rugged
    Fitness Landscapes in Sequence Space.” <i>Trends in Genetics</i>, vol. 31, no.
    1, Elsevier, 2015, pp. 24–33, doi:<a href="https://doi.org/10.1016/j.tig.2014.09.009">10.1016/j.tig.2014.09.009</a>.
  short: D. Kondrashov, F. Kondrashov, Trends in Genetics 31 (2015) 24–33.
date_created: 2018-12-11T11:49:01Z
date_published: 2015-01-01T00:00:00Z
date_updated: 2026-05-19T07:23:54Z
day: '01'
doi: 10.1016/j.tig.2014.09.009
extern: '1'
external_id:
  pmid:
  - '25438718'
intvolume: '        31'
issue: '1'
keyword:
- Mimsatch repair
- Chromatin structure
- Replication fork
- Cancer therapy
language:
- iso: eng
month: '01'
oa_version: None
page: 24 - 33
pmid: 1
publication: Trends in Genetics
publication_identifier:
  eissn:
  - 1362-4555
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
publist_id: '6764'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Topological features of rugged fitness landscapes in sequence space
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 31
year: '2015'
...
---
_id: '7744'
article_processing_charge: No
article_type: original
author:
- first_name: Matthew Richard
  full_name: Robinson, Matthew Richard
  id: E5D42276-F5DA-11E9-8E24-6303E6697425
  last_name: Robinson
  orcid: 0000-0001-8982-8813
- first_name: Naomi R.
  full_name: Wray, Naomi R.
  last_name: Wray
- first_name: Peter M.
  full_name: Visscher, Peter M.
  last_name: Visscher
citation:
  ama: Robinson MR, Wray NR, Visscher PM. Explaining additional genetic variation
    in complex traits. <i>Trends in Genetics</i>. 2014;30(4):124-132. doi:<a href="https://doi.org/10.1016/j.tig.2014.02.003">10.1016/j.tig.2014.02.003</a>
  apa: Robinson, M. R., Wray, N. R., &#38; Visscher, P. M. (2014). Explaining additional
    genetic variation in complex traits. <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2014.02.003">https://doi.org/10.1016/j.tig.2014.02.003</a>
  chicago: Robinson, Matthew Richard, Naomi R. Wray, and Peter M. Visscher. “Explaining
    Additional Genetic Variation in Complex Traits.” <i>Trends in Genetics</i>. Elsevier,
    2014. <a href="https://doi.org/10.1016/j.tig.2014.02.003">https://doi.org/10.1016/j.tig.2014.02.003</a>.
  ieee: M. R. Robinson, N. R. Wray, and P. M. Visscher, “Explaining additional genetic
    variation in complex traits,” <i>Trends in Genetics</i>, vol. 30, no. 4. Elsevier,
    pp. 124–132, 2014.
  ista: Robinson MR, Wray NR, Visscher PM. 2014. Explaining additional genetic variation
    in complex traits. Trends in Genetics. 30(4), 124–132.
  mla: Robinson, Matthew Richard, et al. “Explaining Additional Genetic Variation
    in Complex Traits.” <i>Trends in Genetics</i>, vol. 30, no. 4, Elsevier, 2014,
    pp. 124–32, doi:<a href="https://doi.org/10.1016/j.tig.2014.02.003">10.1016/j.tig.2014.02.003</a>.
  short: M.R. Robinson, N.R. Wray, P.M. Visscher, Trends in Genetics 30 (2014) 124–132.
date_created: 2020-04-30T10:58:58Z
date_published: 2014-04-01T00:00:00Z
date_updated: 2021-01-12T08:15:14Z
day: '01'
doi: 10.1016/j.tig.2014.02.003
extern: '1'
intvolume: '        30'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 124-132
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Explaining additional genetic variation in complex traits
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 30
year: '2014'
...
---
_id: '6135'
abstract:
- lang: eng
  text: Many organisms have stress response pathways, components of which share homology
    with players in complex human disease pathways. Research on stress response in
    the nematode worm Caenorhabditis elegans has provided detailed insights into the
    genetic and molecular mechanisms underlying complex human diseases. In this review
    we focus on four different types of environmental stress responses – heat shock,
    oxidative stress, hypoxia, and osmotic stress – and on how these can be used to
    study the genetics of complex human diseases. All four types of responses involve
    the genetic machineries that underlie a number of complex human diseases such
    as cancer and neurodegenerative diseases, including Alzheimer's and Parkinson's.
    We highlight the types of stress response experiments required to detect the genes
    and pathways underlying human disease and suggest that studying stress biology
    in worms can be translated to understanding human disease and provide potential
    targets for drug discovery.
author:
- first_name: Miriam
  full_name: Rodriguez, Miriam
  last_name: Rodriguez
- first_name: L. Basten
  full_name: Snoek, L. Basten
  last_name: Snoek
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Jan E.
  full_name: Kammenga, Jan E.
  last_name: Kammenga
citation:
  ama: 'Rodriguez M, Snoek LB, de Bono M, Kammenga JE. Worms under stress: C. elegans
    stress response and its relevance to complex human disease and aging. <i>Trends
    in Genetics</i>. 2013;29(6):367-374. doi:<a href="https://doi.org/10.1016/j.tig.2013.01.010">10.1016/j.tig.2013.01.010</a>'
  apa: 'Rodriguez, M., Snoek, L. B., de Bono, M., &#38; Kammenga, J. E. (2013). Worms
    under stress: C. elegans stress response and its relevance to complex human disease
    and aging. <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2013.01.010">https://doi.org/10.1016/j.tig.2013.01.010</a>'
  chicago: 'Rodriguez, Miriam, L. Basten Snoek, Mario de Bono, and Jan E. Kammenga.
    “Worms under Stress: C. Elegans Stress Response and Its Relevance to Complex Human
    Disease and Aging.” <i>Trends in Genetics</i>. Elsevier, 2013. <a href="https://doi.org/10.1016/j.tig.2013.01.010">https://doi.org/10.1016/j.tig.2013.01.010</a>.'
  ieee: 'M. Rodriguez, L. B. Snoek, M. de Bono, and J. E. Kammenga, “Worms under stress:
    C. elegans stress response and its relevance to complex human disease and aging,”
    <i>Trends in Genetics</i>, vol. 29, no. 6. Elsevier, pp. 367–374, 2013.'
  ista: 'Rodriguez M, Snoek LB, de Bono M, Kammenga JE. 2013. Worms under stress:
    C. elegans stress response and its relevance to complex human disease and aging.
    Trends in Genetics. 29(6), 367–374.'
  mla: 'Rodriguez, Miriam, et al. “Worms under Stress: C. Elegans Stress Response
    and Its Relevance to Complex Human Disease and Aging.” <i>Trends in Genetics</i>,
    vol. 29, no. 6, Elsevier, 2013, pp. 367–74, doi:<a href="https://doi.org/10.1016/j.tig.2013.01.010">10.1016/j.tig.2013.01.010</a>.'
  short: M. Rodriguez, L.B. Snoek, M. de Bono, J.E. Kammenga, Trends in Genetics 29
    (2013) 367–374.
date_created: 2019-03-20T14:17:42Z
date_published: 2013-06-01T00:00:00Z
date_updated: 2021-01-12T08:06:17Z
day: '01'
doi: 10.1016/j.tig.2013.01.010
extern: '1'
intvolume: '        29'
issue: '6'
language:
- iso: eng
month: '06'
oa_version: None
page: 367-374
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Worms under stress: C. elegans stress response and its relevance to complex
  human disease and aging'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2013'
...
---
_id: '6148'
author:
- first_name: Jan E.
  full_name: Kammenga, Jan E.
  last_name: Kammenga
- first_name: Patrick C.
  full_name: Phillips, Patrick C.
  last_name: Phillips
- first_name: Mario
  full_name: de Bono, Mario
  id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
  last_name: de Bono
  orcid: 0000-0001-8347-0443
- first_name: Agnieszka
  full_name: Doroszuk, Agnieszka
  last_name: Doroszuk
citation:
  ama: 'Kammenga JE, Phillips PC, de Bono M, Doroszuk A. Beyond induced mutants: using
    worms to study natural variation in genetic pathways. <i>Trends in Genetics</i>.
    2008;24(4):178-185. doi:<a href="https://doi.org/10.1016/j.tig.2008.01.001">10.1016/j.tig.2008.01.001</a>'
  apa: 'Kammenga, J. E., Phillips, P. C., de Bono, M., &#38; Doroszuk, A. (2008).
    Beyond induced mutants: using worms to study natural variation in genetic pathways.
    <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/j.tig.2008.01.001">https://doi.org/10.1016/j.tig.2008.01.001</a>'
  chicago: 'Kammenga, Jan E., Patrick C. Phillips, Mario de Bono, and Agnieszka Doroszuk.
    “Beyond Induced Mutants: Using Worms to Study Natural Variation in Genetic Pathways.”
    <i>Trends in Genetics</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.tig.2008.01.001">https://doi.org/10.1016/j.tig.2008.01.001</a>.'
  ieee: 'J. E. Kammenga, P. C. Phillips, M. de Bono, and A. Doroszuk, “Beyond induced
    mutants: using worms to study natural variation in genetic pathways,” <i>Trends
    in Genetics</i>, vol. 24, no. 4. Elsevier, pp. 178–185, 2008.'
  ista: 'Kammenga JE, Phillips PC, de Bono M, Doroszuk A. 2008. Beyond induced mutants:
    using worms to study natural variation in genetic pathways. Trends in Genetics.
    24(4), 178–185.'
  mla: 'Kammenga, Jan E., et al. “Beyond Induced Mutants: Using Worms to Study Natural
    Variation in Genetic Pathways.” <i>Trends in Genetics</i>, vol. 24, no. 4, Elsevier,
    2008, pp. 178–85, doi:<a href="https://doi.org/10.1016/j.tig.2008.01.001">10.1016/j.tig.2008.01.001</a>.'
  short: J.E. Kammenga, P.C. Phillips, M. de Bono, A. Doroszuk, Trends in Genetics
    24 (2008) 178–185.
date_created: 2019-03-21T08:19:45Z
date_published: 2008-04-01T00:00:00Z
date_updated: 2021-01-12T08:06:21Z
day: '01'
doi: 10.1016/j.tig.2008.01.001
extern: '1'
external_id:
  pmid:
  - '18325626'
intvolume: '        24'
issue: '4'
language:
- iso: eng
month: '04'
oa_version: None
page: 178-185
pmid: 1
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Beyond induced mutants: using worms to study natural variation in genetic
  pathways'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2008'
...
---
_id: '12201'
abstract:
- lang: eng
  text: The development of plant lateral organs is interesting because, although many
    of the same genes seem to be involved in the early growth of primordia, completely
    different gene combinations are required for the complete development of organs
    such as leaves and stamens. Thus, the genes common to the development of most
    organs, which generally form and polarize the primordial ‘envelope’, must at some
    stage interact with those that ‘install’ the functional content of the organ –
    in the case of the stamen, the four microsporangia. Although distinct genetic
    pathways of organ initiation, polarity establishment and setting up the reproductive
    cell line can readily be recognized, they do not occur sequentially. Rather, they
    are activated early and run in parallel. There is evidence for continuing crosstalk
    between these pathways.
acknowledgement: X.F. holds a Clarendon Scholarship from the University of Oxford.
  We thank Angela Hay and Jill Harrison for helpful advice and discussion.
article_processing_charge: No
article_type: original
author:
- first_name: Xiaoqi
  full_name: Feng, Xiaoqi
  id: e0164712-22ee-11ed-b12a-d80fcdf35958
  last_name: Feng
  orcid: 0000-0002-4008-1234
- first_name: Hugh G.
  full_name: Dickinson, Hugh G.
  last_name: Dickinson
citation:
  ama: Feng X, Dickinson HG. Packaging the male germline in plants. <i>Trends in Genetics</i>.
    2007;23(10):503-510. doi:<a href="https://doi.org/10.1016/j.tig.2007.08.005">10.1016/j.tig.2007.08.005</a>
  apa: Feng, X., &#38; Dickinson, H. G. (2007). Packaging the male germline in plants.
    <i>Trends in Genetics</i>. Elsevier BV. <a href="https://doi.org/10.1016/j.tig.2007.08.005">https://doi.org/10.1016/j.tig.2007.08.005</a>
  chicago: Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.”
    <i>Trends in Genetics</i>. Elsevier BV, 2007. <a href="https://doi.org/10.1016/j.tig.2007.08.005">https://doi.org/10.1016/j.tig.2007.08.005</a>.
  ieee: X. Feng and H. G. Dickinson, “Packaging the male germline in plants,” <i>Trends
    in Genetics</i>, vol. 23, no. 10. Elsevier BV, pp. 503–510, 2007.
  ista: Feng X, Dickinson HG. 2007. Packaging the male germline in plants. Trends
    in Genetics. 23(10), 503–510.
  mla: Feng, Xiaoqi, and Hugh G. Dickinson. “Packaging the Male Germline in Plants.”
    <i>Trends in Genetics</i>, vol. 23, no. 10, Elsevier BV, 2007, pp. 503–10, doi:<a
    href="https://doi.org/10.1016/j.tig.2007.08.005">10.1016/j.tig.2007.08.005</a>.
  short: X. Feng, H.G. Dickinson, Trends in Genetics 23 (2007) 503–510.
date_created: 2023-01-16T09:22:44Z
date_published: 2007-10-01T00:00:00Z
date_updated: 2023-05-08T10:58:47Z
department:
- _id: XiFe
doi: 10.1016/j.tig.2007.08.005
extern: '1'
external_id:
  pmid:
  - '17825943'
intvolume: '        23'
issue: '10'
keyword:
- Genetics
language:
- iso: eng
month: '10'
oa_version: None
page: 503-510
pmid: 1
publication: Trends in Genetics
publication_identifier:
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier BV
quality_controlled: '1'
scopus_import: '1'
status: public
title: Packaging the male germline in plants
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2007'
...
---
OA_type: closed access
_id: '876'
abstract:
- lang: eng
  text: Alternative splicing is thought to be a major source of functional diversity
    in animal proteins. We analyzed the evolutionary conservation of proteins encoded
    by alternatively spliced genes and predicted the ancestral state for 73 cases
    of alternative splicing (25 insertions and 48 deletions). The amino acid sequences
    of most of the inserts in proteins produced by alternative splicing are as conserved
    as the surrounding sequences. Thus, alternative splicing often creates novel isoforms
    by the insertion of new, functional protein sequences that probably originated
    from noncoding sequences of introns.
acknowledgement: We thank Peer Bork, Mikhail Gelfand, Alexey Kondrashov, David Lipman
  and Shamil Sunyaev for critical reading of the manuscript and useful suggestions
  and the Koonin group members for helpful discussions.
article_processing_charge: No
article_type: original
author:
- first_name: Fyodor
  full_name: Kondrashov, Fyodor
  id: 44FDEF62-F248-11E8-B48F-1D18A9856A87
  last_name: Kondrashov
  orcid: 0000-0001-8243-4694
- first_name: Eugene
  full_name: Koonin, Eugene
  last_name: Koonin
citation:
  ama: 'Kondrashov F, Koonin E. Evolution of alternative splicing: Deletions, insertions
    and origin of functional parts of proteins from intron sequences. <i>Trends in
    Genetics</i>. 2003;19(3):115-119. doi:<a href="https://doi.org/10.1016/S0168-9525(02)00029-X">10.1016/S0168-9525(02)00029-X</a>'
  apa: 'Kondrashov, F., &#38; Koonin, E. (2003). Evolution of alternative splicing:
    Deletions, insertions and origin of functional parts of proteins from intron sequences.
    <i>Trends in Genetics</i>. Elsevier. <a href="https://doi.org/10.1016/S0168-9525(02)00029-X">https://doi.org/10.1016/S0168-9525(02)00029-X</a>'
  chicago: 'Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing:
    Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.”
    <i>Trends in Genetics</i>. Elsevier, 2003. <a href="https://doi.org/10.1016/S0168-9525(02)00029-X">https://doi.org/10.1016/S0168-9525(02)00029-X</a>.'
  ieee: 'F. Kondrashov and E. Koonin, “Evolution of alternative splicing: Deletions,
    insertions and origin of functional parts of proteins from intron sequences,”
    <i>Trends in Genetics</i>, vol. 19, no. 3. Elsevier, pp. 115–119, 2003.'
  ista: 'Kondrashov F, Koonin E. 2003. Evolution of alternative splicing: Deletions,
    insertions and origin of functional parts of proteins from intron sequences. Trends
    in Genetics. 19(3), 115–119.'
  mla: 'Kondrashov, Fyodor, and Eugene Koonin. “Evolution of Alternative Splicing:
    Deletions, Insertions and Origin of Functional Parts of Proteins from Intron Sequences.”
    <i>Trends in Genetics</i>, vol. 19, no. 3, Elsevier, 2003, pp. 115–19, doi:<a
    href="https://doi.org/10.1016/S0168-9525(02)00029-X">10.1016/S0168-9525(02)00029-X</a>.'
  short: F. Kondrashov, E. Koonin, Trends in Genetics 19 (2003) 115–119.
date_created: 2018-12-11T11:48:58Z
date_published: 2003-03-01T00:00:00Z
date_updated: 2026-05-28T13:49:56Z
day: '01'
doi: 10.1016/S0168-9525(02)00029-X
extern: '1'
external_id:
  pmid:
  - '12615001'
intvolume: '        19'
issue: '3'
language:
- iso: eng
month: '03'
oa_version: None
page: 115 - 119
pmid: 1
publication: Trends in Genetics
publication_identifier:
  eissn:
  - 1362-4555
  issn:
  - 0168-9525
publication_status: published
publisher: Elsevier
publist_id: '6776'
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Evolution of alternative splicing: Deletions, insertions and origin of functional
  parts of proteins from intron sequences'
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 19
year: '2003'
...