---
OA_type: closed access
_id: '3804'
abstract:
- lang: eng
text: Kv3 channels are thought to be essential for the fast-spiking (FS) phenotype
in GABAergic interneurons, but how these channels confer the ability to generate
action potentials (APs) at high frequency is unknown. To address this question,
we developed a fast dynamic-clamp system (approximately 50 kHz) that allowed us
to add a Kv3 model conductance to CA1 oriens alveus (OA) interneurons in hippocampal
slices. Selective pharmacological block of Kv3 channels by 0.3 mm 4-aminopyridine
or 1 mm tetraethylammonium ions led to a marked broadening of APs during trains
of short stimuli and a reduction in AP frequency during 1 sec stimuli. The addition
of artificial Kv3 conductance restored the original AP pattern. Subtraction of
Kv3 conductance by dynamic clamp mimicked the effects of the blockers. Application
of artificial Kv3 conductance also led to FS in OA interneurons after complete
K+ channel block and even induced FS in hippocampal pyramidal neurons in the absence
of blockers. Adding artificial Kv3 conductance with altered deactivation kinetics
revealed a nonmonotonic relationship between mean AP frequency and deactivation
rate, with a maximum slightly above the original value. Insertion of artificial
Kv3 conductance with either lowered activation threshold or inactivation also
led to a reduction in the mean AP frequency. However, the mechanisms were distinct.
Shifting the activation threshold induced adaptation, whereas adding inactivation
caused frequency-dependent AP broadening. In conclusion, Kv3 channels are necessary
for the FS phenotype of OA interneurons, and several of their gating properties
appear to be optimized for high-frequency repetitive activity.
article_processing_charge: No
article_type: original
author:
- first_name: Cheng
full_name: Lien, Cheng
last_name: Lien
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Lien C, Jonas PM. Kv3 potassium conductance is necessary and kinetically optimized
for high-frequency action potential generation in hippocampal interneurons. Journal
of Neuroscience. 2003;23(6):2058-2068. doi:10.1523/JNEUROSCI.23-06-02058.2003
apa: Lien, C., & Jonas, P. M. (2003). Kv3 potassium conductance is necessary
and kinetically optimized for high-frequency action potential generation in hippocampal
interneurons. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.23-06-02058.2003
chicago: Lien, Cheng, and Peter M Jonas. “Kv3 Potassium Conductance Is Necessary
and Kinetically Optimized for High-Frequency Action Potential Generation in Hippocampal
Interneurons.” Journal of Neuroscience. Society for Neuroscience, 2003.
https://doi.org/10.1523/JNEUROSCI.23-06-02058.2003.
ieee: C. Lien and P. M. Jonas, “Kv3 potassium conductance is necessary and kinetically
optimized for high-frequency action potential generation in hippocampal interneurons,”
Journal of Neuroscience, vol. 23, no. 6. Society for Neuroscience, pp.
2058–68, 2003.
ista: Lien C, Jonas PM. 2003. Kv3 potassium conductance is necessary and kinetically
optimized for high-frequency action potential generation in hippocampal interneurons.
Journal of Neuroscience. 23(6), 2058–68.
mla: Lien, Cheng, and Peter M. Jonas. “Kv3 Potassium Conductance Is Necessary and
Kinetically Optimized for High-Frequency Action Potential Generation in Hippocampal
Interneurons.” Journal of Neuroscience, vol. 23, no. 6, Society for Neuroscience,
2003, pp. 2058–68, doi:10.1523/JNEUROSCI.23-06-02058.2003.
short: C. Lien, P.M. Jonas, Journal of Neuroscience 23 (2003) 2058–68.
date_created: 2018-12-11T12:05:16Z
date_published: 2003-03-15T00:00:00Z
date_updated: 2026-05-08T09:38:20Z
day: '15'
doi: 10.1523/JNEUROSCI.23-06-02058.2003
extern: '1'
external_id:
pmid:
- '12657664'
fulldoi: https://doi.org/10.1523/JNEUROSCI.23-06-02058.2003
intvolume: ' 23'
issue: '6'
keyword:
- Kv3 channels
- dynamic clamp
- fast spiking
- deactivation kinetics
- OA interneurons
- hippocampal slices
- two electrode current clamp
language:
- iso: eng
month: '03'
oa_version: None
page: 2058 - 68
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
eissn:
- 1529-2401
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2406'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Kv3 potassium conductance is necessary and kinetically optimized for high-frequency
action potential generation in hippocampal interneurons
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 23
year: '2003'
...
---
_id: '2613'
abstract:
- lang: eng
text: In this investigation, we report identification and characterization of a
95 kDa postsynaptic density protein (PSD-95)/discs-large/ ZO-1 (PDZ) domain-containing
protein termed tamalin, also recently named GRP1-associated scaffold protein (GRASP),
that interacts with group 1 metabotropic glutamate receptors (mGluRs). The yeast
two-hybrid system and in vitro pull-down assays indicated that the PDZ domain-containing,
amino-terminal half of tamalin directly binds to the class I PDZ-binding motif
of group 1 mGluRs. The C-terminal half of tamalin also bound to cytohesins, the
members of guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation
factor (ARF) family of small GTP-binding proteins. Tamalin mRNA is expressed predominantly
in the telencephalic region and highly overlaps with the expression of group 1
mGluR mRNAs. Both tamalin and cytohesin-2 were enriched and codistributed with
mGluR1a in postsynaptic membrane fractions. Importantly, recombinant and native
mGluR1a/tamalin/cytohesin-2 complexes were coimmunoprecipitated from transfected
COS-7 cells and rat brain tissue, respectively. Transfection of tamalin and mutant
tamalin lacking a cytohesin-binding domain caused an increase and decrease in
cell-surface expression of mGluR1a in COS-7 cells, respectively. Furthermore,
adenovirus-mediated expression of tamalin and dominant-negative tamalin facilitated
and reduced the neuritic distribution of endogenous mGluR5 in cultured hippocampal
neurons, respectively. The results indicate that tamalin plays a key role in the
association of group 1 mGluRs with the ARF-specific GEF proteins and contributes
to intracellular trafficking and the macromolecular organization of group 1 mGluRs
at synapses.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science and Culture of Japan. We thank Bert Vogelstein for providing
adenoviral recombination vectors and Haruhiko Bito for a gift of the enolase promoter
and technical advice. We are grateful to Atsushi Nishimune and Satoshi Kaneko for
technical advice and Kumlesh K. Dev for careful reading of this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Jun
full_name: Kitano, Jun
last_name: Kitano
- first_name: Kouji
full_name: Kimura, Kouji
last_name: Kimura
- first_name: Yoshimitsu
full_name: Yamazaki, Yoshimitsu
last_name: Yamazaki
- first_name: Takeshi
full_name: Soda, Takeshi
last_name: Soda
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Yoshiaki
full_name: Nakajima, Yoshiaki
last_name: Nakajima
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Kitano J, Kimura K, Yamazaki Y, et al. Tamalin, a PDZ domain-containing protein,
links a protein complex formation of group 1 metabotropic glutamate receptors
and the guanine nucleotide exchange factor cytohesins. Journal of Neuroscience.
2002;22(4):1280-1289. doi:10.1523/JNEUROSCI.22-04-01280.2002
apa: Kitano, J., Kimura, K., Yamazaki, Y., Soda, T., Shigemoto, R., Nakajima, Y.,
& Nakanishi, S. (2002). Tamalin, a PDZ domain-containing protein, links a
protein complex formation of group 1 metabotropic glutamate receptors and the
guanine nucleotide exchange factor cytohesins. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002
chicago: Kitano, Jun, Kouji Kimura, Yoshimitsu Yamazaki, Takeshi Soda, Ryuichi Shigemoto,
Yoshiaki Nakajima, and Shigetada Nakanishi. “Tamalin, a PDZ Domain-Containing
Protein, Links a Protein Complex Formation of Group 1 Metabotropic Glutamate Receptors
and the Guanine Nucleotide Exchange Factor Cytohesins.” Journal of Neuroscience.
Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002.
ieee: J. Kitano et al., “Tamalin, a PDZ domain-containing protein, links
a protein complex formation of group 1 metabotropic glutamate receptors and the
guanine nucleotide exchange factor cytohesins,” Journal of Neuroscience,
vol. 22, no. 4. Society for Neuroscience, pp. 1280–1289, 2002.
ista: Kitano J, Kimura K, Yamazaki Y, Soda T, Shigemoto R, Nakajima Y, Nakanishi
S. 2002. Tamalin, a PDZ domain-containing protein, links a protein complex formation
of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange
factor cytohesins. Journal of Neuroscience. 22(4), 1280–1289.
mla: Kitano, Jun, et al. “Tamalin, a PDZ Domain-Containing Protein, Links a Protein
Complex Formation of Group 1 Metabotropic Glutamate Receptors and the Guanine
Nucleotide Exchange Factor Cytohesins.” Journal of Neuroscience, vol. 22,
no. 4, Society for Neuroscience, 2002, pp. 1280–89, doi:10.1523/JNEUROSCI.22-04-01280.2002.
short: J. Kitano, K. Kimura, Y. Yamazaki, T. Soda, R. Shigemoto, Y. Nakajima, S.
Nakanishi, Journal of Neuroscience 22 (2002) 1280–1289.
date_created: 2018-12-11T11:58:40Z
date_published: 2002-02-15T00:00:00Z
date_updated: 2023-07-25T11:34:46Z
day: '15'
doi: 10.1523/JNEUROSCI.22-04-01280.2002
extern: '1'
external_id:
pmid:
- '11850456'
fulldoi: https://doi.org/10.1523/JNEUROSCI.22-04-01280.2002
intvolume: ' 22'
issue: '4'
language:
- iso: eng
month: '02'
oa_version: None
page: 1280 - 1289
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4285'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tamalin, a PDZ domain-containing protein, links a protein complex formation
of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange
factor cytohesins
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2002'
...
---
_id: '3802'
abstract:
- lang: eng
text: The presynaptic Ca2+ signal is a key determinant of transmitter release at
chemical synapses. In cortical synaptic terminals, however, little is known about
the kinetic properties of the presynaptic Ca2+ channels. To investigate the timing
and magnitude of the presynaptic Ca2+ inflow, we performed whole-cell patch-clamp
recordings from mossy fiber boutons (MFBs) in rat hippocampus. MFBs showed large
high-voltage-activated Ca(2+) currents, with a maximal amplitude of approximately
100 pA at a membrane potential of 0 mV. Both activation and deactivation were
fast, with time constants in the submillisecond range at a temperature of approximately
23 degrees C. An MFB action potential (AP) applied as a voltage-clamp command
evoked a transient Ca2+ current with an average amplitude of approximately 170
pA and a half-duration of 580 microsec. A prepulse to +40 mV had only minimal
effects on the AP-evoked Ca2+ current, indicating that presynaptic APs open the
voltage-gated Ca2+ channels very effectively. On the basis of the experimental
data, we developed a kinetic model with four closed states and one open state,
linked by voltage-dependent rate constants. Simulations of the Ca2+ current could
reproduce the experimental data, including the large amplitude and rapid time
course of the current evoked by MFB APs. Furthermore, the simulations indicate
that the shape of the presynaptic AP and the gating kinetics of the Ca2+ channels
are tuned to produce a maximal Ca2+ influx during a minimal period of time. The
precise timing and high efficacy of Ca2+ channel activation at this cortical glutamatergic
synapse may be important for synchronous transmitter release and temporal information
processing.
acknowledgement: J.B. was supported by grants from the Deutsche Forschungsgemeinschaft
(Bi 642/1-2 and SFB 505/C9). We thank Dr. U. Kraushaar, Dr. S. Hefft, and C. Schmidt-Hieber
for critically reading this manuscript, F. Heyde for secretarial help, and A. Blomenkamp
and K. Winterhalter for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Josef
full_name: Bischofberger, Josef
last_name: Bischofberger
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bischofberger J, Geiger J, Jonas PM. Timing and efficacy of Ca(2+) channel
activation in hippocampal mossy fiber boutons. Journal of Neuroscience.
2002;22(24):10593-10602. doi:10.1523/JNEUROSCI.22-24-10593.2002
apa: Bischofberger, J., Geiger, J., & Jonas, P. M. (2002). Timing and efficacy
of Ca(2+) channel activation in hippocampal mossy fiber boutons. Journal of
Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002
chicago: Bischofberger, Josef, Jörg Geiger, and Peter M Jonas. “Timing and Efficacy
of Ca(2+) Channel Activation in Hippocampal Mossy Fiber Boutons.” Journal of
Neuroscience. Society for Neuroscience, 2002. https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002.
ieee: J. Bischofberger, J. Geiger, and P. M. Jonas, “Timing and efficacy of Ca(2+)
channel activation in hippocampal mossy fiber boutons,” Journal of Neuroscience,
vol. 22, no. 24. Society for Neuroscience, pp. 10593–10602, 2002.
ista: Bischofberger J, Geiger J, Jonas PM. 2002. Timing and efficacy of Ca(2+) channel
activation in hippocampal mossy fiber boutons. Journal of Neuroscience. 22(24),
10593–10602.
mla: Bischofberger, Josef, et al. “Timing and Efficacy of Ca(2+) Channel Activation
in Hippocampal Mossy Fiber Boutons.” Journal of Neuroscience, vol. 22,
no. 24, Society for Neuroscience, 2002, pp. 10593–602, doi:10.1523/JNEUROSCI.22-24-10593.2002.
short: J. Bischofberger, J. Geiger, P.M. Jonas, Journal of Neuroscience 22 (2002)
10593–10602.
date_created: 2018-12-11T12:05:15Z
date_published: 2002-12-01T00:00:00Z
date_updated: 2023-06-13T13:19:45Z
day: '01'
doi: 10.1523/JNEUROSCI.22-24-10593.2002
extern: '1'
external_id:
pmid:
- '12486151'
fulldoi: https://doi.org/10.1523/JNEUROSCI.22-24-10593.2002
intvolume: ' 22'
issue: '24'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6758411/
month: '12'
oa: 1
oa_version: Published Version
page: 10593 - 10602
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2407'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Timing and efficacy of Ca(2+) channel activation in hippocampal mossy fiber
boutons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 22
year: '2002'
...
---
_id: '2610'
abstract:
- lang: eng
text: To study the role of mGlu7 receptors (mGluR7), we used homologous recombination
to generate mice lacking this metabotropic receptor subtype (mGluR7 -/-). After
the serendipitous discovery of a sensory stimulus-evoked epileptic phenotype,
we tested two convulsant drugs, pentylenetetrazole (PTZ) and bicuculline. In animals
aged 12 weeks and older, subthreshold doses of these drugs induced seizures in
mGluR7 -/-, but not in mGluR7 +/-, mice. PTZ-induced seizures were inhibited by
three standard anticonvulsant drugs, but not by the group III selective mGluR
agonist (R,S)-4-phosphonophenylglycine (PPG). Consistent with the lack of signs
of epileptic activity in the absence of specific stimuli, mGluR7 -/- mice showed
no major changes in synaptic properties in two slice preparations. However, slightly
increased excitability was evident in hippocampal slices. In addition, there was
slower recovery from frequency facilitation in cortical slices, suggesting a role
for mGluR7 as a frequency-dependent regulator in presynaptic terminals. Our findings
suggest that mGluR7 receptors have a unique role in regulating neuronal excitability
and that these receptors may be a novel target for the development of anticonvulsant
drugs.
acknowledgement: This work was supported in part by the Biotechnology and Biological
Sciences Research Council and Medical Research Council (UK). We thank Doris Ruegg
for sequencing, Gemma Texido and Klaus Rajewsky for pTV-0 DNA, J.-F. Pin for mGluR8
cDNA, K. von Figura for E14 ES cells, Pedro Grandes for histological examination
of brain sections, Christoph Wiessner for help with plots and statistics, Valerie
Schuler for help with Western blots, and the team of the Novartis special strain
breeding facility for their support.
article_processing_charge: No
article_type: original
author:
- first_name: Gilles
full_name: Sansig, Gilles
last_name: Sansig
- first_name: Trevor
full_name: Bushell, Trevor
last_name: Bushell
- first_name: Vernon
full_name: Clarke, Vernon
last_name: Clarke
- first_name: Andrei
full_name: Rozov, Andrei
last_name: Rozov
- first_name: Nail
full_name: Burnashev, Nail
last_name: Burnashev
- first_name: Chantal
full_name: Portet, Chantal
last_name: Portet
- first_name: Fabrizio
full_name: Gasparini, Fabrizio
last_name: Gasparini
- first_name: Markus
full_name: Schmutz, Markus
last_name: Schmutz
- first_name: Klaus
full_name: Klebs, Klaus
last_name: Klebs
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Rainer
full_name: Kühn, Rainer
last_name: Kühn
- first_name: Thomas
full_name: Knoepfel, Thomas
last_name: Knoepfel
- first_name: Markus
full_name: Schroeder, Markus
last_name: Schroeder
- first_name: David
full_name: Hampson, David
last_name: Hampson
- first_name: Valerie
full_name: Collett, Valerie
last_name: Collett
- first_name: Congxiao
full_name: Zhang, Congxiao
last_name: Zhang
- first_name: Robert
full_name: Duvoisin, Robert
last_name: Duvoisin
- first_name: Graham
full_name: Collingridge, Graham
last_name: Collingridge
- first_name: Herman
full_name: Van Der Putten, Herman
last_name: Van Der Putten
citation:
ama: Sansig G, Bushell T, Clarke V, et al. Increased seizure susceptibility in mice
lacking metabotropic glutamate receptor 7. Journal of Neuroscience. 2001;21(22):8734-8745.
doi:10.1523/JNEUROSCI.21-22-08734.2001
apa: Sansig, G., Bushell, T., Clarke, V., Rozov, A., Burnashev, N., Portet, C.,
… Van Der Putten, H. (2001). Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001
chicago: Sansig, Gilles, Trevor Bushell, Vernon Clarke, Andrei Rozov, Nail Burnashev,
Chantal Portet, Fabrizio Gasparini, et al. “Increased Seizure Susceptibility in
Mice Lacking Metabotropic Glutamate Receptor 7.” Journal of Neuroscience.
Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001.
ieee: G. Sansig et al., “Increased seizure susceptibility in mice lacking
metabotropic glutamate receptor 7,” Journal of Neuroscience, vol. 21, no.
22. Society for Neuroscience, pp. 8734–8745, 2001.
ista: Sansig G, Bushell T, Clarke V, Rozov A, Burnashev N, Portet C, Gasparini F,
Schmutz M, Klebs K, Shigemoto R, Flor P, Kühn R, Knoepfel T, Schroeder M, Hampson
D, Collett V, Zhang C, Duvoisin R, Collingridge G, Van Der Putten H. 2001. Increased
seizure susceptibility in mice lacking metabotropic glutamate receptor 7. Journal
of Neuroscience. 21(22), 8734–8745.
mla: Sansig, Gilles, et al. “Increased Seizure Susceptibility in Mice Lacking Metabotropic
Glutamate Receptor 7.” Journal of Neuroscience, vol. 21, no. 22, Society
for Neuroscience, 2001, pp. 8734–45, doi:10.1523/JNEUROSCI.21-22-08734.2001.
short: G. Sansig, T. Bushell, V. Clarke, A. Rozov, N. Burnashev, C. Portet, F. Gasparini,
M. Schmutz, K. Klebs, R. Shigemoto, P. Flor, R. Kühn, T. Knoepfel, M. Schroeder,
D. Hampson, V. Collett, C. Zhang, R. Duvoisin, G. Collingridge, H. Van Der Putten,
Journal of Neuroscience 21 (2001) 8734–8745.
date_created: 2018-12-11T11:58:39Z
date_published: 2001-11-15T00:00:00Z
date_updated: 2023-05-24T08:47:53Z
day: '15'
doi: 10.1523/JNEUROSCI.21-22-08734.2001
extern: '1'
external_id:
pmid:
- '11698585'
fulldoi: https://doi.org/10.1523/JNEUROSCI.21-22-08734.2001
intvolume: ' 21'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6762269/
month: '11'
oa: 1
oa_version: Published Version
page: 8734 - 8745
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4288'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Increased seizure susceptibility in mice lacking metabotropic glutamate receptor
7
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '3494'
abstract:
- lang: eng
text: 'Mutual synaptic interactions between GABAergic interneurons are thought to
be of critical importance for the generation of network oscillations and for temporal
encoding of information in the hippocampus. However, the functional properties
of synaptic transmission between hippocampal interneurons are largely unknown.
We have made paired recordings from basket cells (BCs) in the dentate gyrus of
rat hippocampal slices, followed by correlated light and electron microscopical
analysis. Unitary GABAAreceptor-mediated IPSCs at BC–BC synapses recorded at the
soma showed a fast rise and decay, with a mean decay time constant of 2.5 ± 0.2
msec (32°C). Synaptic transmission at BC–BC synapses showed paired-pulse depression
(PPD) (32 ± 5% for 10 msec interpulse intervals) and multiple-pulse depression
during repetitive stimulation. Detailed passive cable model simulations based
on somatodendritic morphology and localization of synaptic contacts further indicated
that the conductance change at the postsynaptic site was even faster, decaying
with a mean time constant of 1.8 ± 0.6 msec. Sequential triple recordings revealed
that the decay time course of IPSCs at BC–BC synapses was approximately twofold
faster than that at BC–granule cell synapses, whereas the extent of PPD was comparable.
To examine the consequences of the fast postsynaptic conductance change for the
generation of oscillatory activity, we developed a computational model of an interneuron
network. The model showed robust oscillations at frequencies >60 Hz if the
excitatory drive was sufficiently large. Thus the fast conductance change at interneuron–interneuron
synapses may promote the generation of high-frequency oscillations observed in
the dentate gyrusin vivo. '
acknowledgement: This work was supported by grants of the Deutsche Forschungsgemeinschaft
(SFB 505/C6) and the Human Frontiers Science Program Organization (RG0017/1998-B).
We thank Drs. M. V. Jones, J. Bischofberger, and U. Kraushaar for critically reading
this manuscript. We also thank B. Taskin and A. Roth for advice in the use of reconstruction
and modeling software, and S. Nestel, M. Winter, and A. Blomenkamp for technical
assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Marlene
full_name: Bartos, Marlene
last_name: Bartos
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. Rapid signaling at inhibitory
synapses in a dentate gyrus interneuron network. Journal of Neuroscience.
2001;21(8):2687-2698. doi:10.1523/JNEUROSCI.21-08-02687.2001
apa: Bartos, M., Vida, I., Frotscher, M., Geiger, J., & Jonas, P. M. (2001).
Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001
chicago: Bartos, Marlene, Imre Vida, Michael Frotscher, Jörg Geiger, and Peter M
Jonas. “Rapid Signaling at Inhibitory Synapses in a Dentate Gyrus Interneuron
Network.” Journal of Neuroscience. Society for Neuroscience, 2001. https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001.
ieee: M. Bartos, I. Vida, M. Frotscher, J. Geiger, and P. M. Jonas, “Rapid signaling
at inhibitory synapses in a dentate gyrus interneuron network.,” Journal of
Neuroscience, vol. 21, no. 8. Society for Neuroscience, pp. 2687–2698, 2001.
ista: Bartos M, Vida I, Frotscher M, Geiger J, Jonas PM. 2001. Rapid signaling at
inhibitory synapses in a dentate gyrus interneuron network. Journal of Neuroscience.
21(8), 2687–2698.
mla: Bartos, Marlene, et al. “Rapid Signaling at Inhibitory Synapses in a Dentate
Gyrus Interneuron Network.” Journal of Neuroscience, vol. 21, no. 8, Society
for Neuroscience, 2001, pp. 2687–98, doi:10.1523/JNEUROSCI.21-08-02687.2001.
short: M. Bartos, I. Vida, M. Frotscher, J. Geiger, P.M. Jonas, Journal of Neuroscience
21 (2001) 2687–2698.
date_created: 2018-12-11T12:03:37Z
date_published: 2001-04-15T00:00:00Z
date_updated: 2023-05-15T13:47:04Z
day: '15'
doi: 10.1523/JNEUROSCI.21-08-02687.2001
extern: '1'
external_id:
pmid:
- '11306622'
fulldoi: https://doi.org/10.1523/JNEUROSCI.21-08-02687.2001
intvolume: ' 21'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ncbi.nlm.nih.gov/pmc/articles/PMC6762544/
month: '04'
oa: 1
oa_version: Published Version
page: 2687 - 2698
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2893'
quality_controlled: '1'
status: public
title: Rapid signaling at inhibitory synapses in a dentate gyrus interneuron network.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '3546'
abstract:
- lang: eng
text: Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated
in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a
significantly stronger relationship among local (<140 <mu>m) pyramidal
neurons compared with distant (>300 mum) neurons during non-theta-associated
immobility and sleep but not during theta-associated running and walking. In contrast,
cross-correlation between local pyramidal cell-interneuron pairs was significantly
stronger than between distant pairs during theta oscillations but were similar
during non-theta-associated behaviors. We suggest that network state-dependent
functional clustering of neuronal activity emerges because of the differential
contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals
during theta and non-theta behaviors.
article_processing_charge: No
article_type: original
author:
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: Xavier
full_name: Leinekugel, Xavier
last_name: Leinekugel
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 2001;21(10). doi:10.1523/JNEUROSCI.21-10-j0003.2001
apa: Hirase, H., Leinekugel, X., Csicsvari, J. L., Czurkó, A., & Buzsáki, G.
(2001). Behavior-dependent states of the hippocampal network affect functional
clustering of neurons. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001
chicago: Hirase, Hajima, Xavier Leinekugel, Jozsef L Csicsvari, András Czurkó, and
György Buzsáki. “Behavior-Dependent States of the Hippocampal Network Affect Functional
Clustering of Neurons.” Journal of Neuroscience. Society for Neuroscience,
2001. https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001.
ieee: H. Hirase, X. Leinekugel, J. L. Csicsvari, A. Czurkó, and G. Buzsáki, “Behavior-dependent
states of the hippocampal network affect functional clustering of neurons,” Journal
of Neuroscience, vol. 21, no. 10. Society for Neuroscience, 2001.
ista: Hirase H, Leinekugel X, Csicsvari JL, Czurkó A, Buzsáki G. 2001. Behavior-dependent
states of the hippocampal network affect functional clustering of neurons. Journal
of Neuroscience. 21(10).
mla: Hirase, Hajima, et al. “Behavior-Dependent States of the Hippocampal Network
Affect Functional Clustering of Neurons.” Journal of Neuroscience, vol.
21, no. 10, Society for Neuroscience, 2001, doi:10.1523/JNEUROSCI.21-10-j0003.2001.
short: H. Hirase, X. Leinekugel, J.L. Csicsvari, A. Czurkó, G. Buzsáki, Journal
of Neuroscience 21 (2001).
date_created: 2018-12-11T12:03:54Z
date_published: 2001-05-15T00:00:00Z
date_updated: 2023-05-12T09:47:39Z
day: '15'
doi: 10.1523/JNEUROSCI.21-10-j0003.2001
extern: '1'
external_id:
pmid:
- '11319243'
fulldoi: https://doi.org/10.1523/JNEUROSCI.21-10-j0003.2001
intvolume: ' 21'
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://pubmed.ncbi.nlm.nih.gov/11319243/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2839'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Behavior-dependent states of the hippocampal network affect functional clustering
of neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 21
year: '2001'
...
---
_id: '2602'
abstract:
- lang: eng
text: Although presynaptic localization of mGluR7 is well established, the mechanism
by which the receptor may control Ca2+ channels in neurons is still unknown. We
show here that cultured cerebellar granule cells express native metabotropic glutamate
receptor type 7 (mGluR7) in neuritic processes, whereas transfected mGluR7 was
also expressed in cell bodies. This allowed us to study the effect of the transfected
receptor on somatic Ca2+ channels. In transfected neurons, mGuR7 selectively inhibited
P/Q-type Ca2+ channels. The effect was mimicked by GTPγS and blocked by pertussis
toxin (PTX) or a selective antibody raised against the G-protein αo subunit, indicating
the involvement of a G(o)-like protein. The mGuR7 effect did not display the characteristics
of a direct interaction between G-protein βγ subunits and the α1A Ca2+ channel
subunit, but was abolished by quenching βγ subunits with specific intracellular
peptides. Intracellular dialysis of G-protein βγ subunits did not mimic the action
of mGluR7, suggesting that both G-protein βγ and αo subunits were required to
mediate the effect. Inhibition of phospholipase C (PLC) blocked the inhibitory
action of mGluR7, suggesting that a coincident activation of PLC by the G-protein
βγ with αo subunits was required. The Ca2+ chelator BAPTA, as well as inhibition
of either the inositol trisphosphate (IP3) receptor or protein kinase C (PKC)
abolished the mGluR7 effect. Moreover, activation of native mGluR7 induced a PTX-dependent
IP3 formation. These results indicated that IP3-mediated intracellular Ca2+ release
was required for PKC-dependent inhibition of the Ca2+ channels. Possible control
of synaptic transmission by the present mechanisms is discussed.
acknowledgement: This work was supported by Centre National de la Recherche Scientifique
and grants from Association Française contre les Myopathies, Fondation pour la Recherche
Médicale, Bayer (France), and Hoechst-Marrion-Roussel (FRHMR1/9702). We thank J.
P. Pin and F. Ango for constructive discussion of this work. We also thank Dr. J.
Saugstad (Atlanta, GA) for the rat mGluR7a cDNA, J. M. Sabatier (Marseille, France)
for the synthesis of the 68 AA peptide, V. Homburger (Montpellier, France) for the
anti-Gαo antibody, and B. Mouillac (Montpellier, France) for the anti-cMyc monoclonal
antibody.
article_processing_charge: No
article_type: original
author:
- first_name: Julie
full_name: Perroy, Julie
last_name: Perroy
- first_name: Laurent
full_name: Prezèau, Laurent
last_name: Prezèau
- first_name: Michel
full_name: De Waard, Michel
last_name: De Waard
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Joël
full_name: Bockaërt, Joël
last_name: Bockaërt
- first_name: Laurent
full_name: Fagni, Laurent
last_name: Fagni
citation:
ama: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience.
2000;20(21):7896-7904. doi:10.1523/JNEUROSCI.20-21-07896.2000
apa: Perroy, J., Prezèau, L., De Waard, M., Shigemoto, R., Bockaërt, J., & Fagni,
L. (2000). Selective blockade of P/Q-type calcium channels by the metabotropic
glutamate receptor type 7 involves a phospholipase C pathway in neurons. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000
chicago: Perroy, Julie, Laurent Prezèau, Michel De Waard, Ryuichi Shigemoto, Joël
Bockaërt, and Laurent Fagni. “Selective Blockade of P/Q-Type Calcium Channels
by the Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway
in Neurons.” Journal of Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000.
ieee: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, and L. Fagni,
“Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons,” Journal of
Neuroscience, vol. 20, no. 21. Society for Neuroscience, pp. 7896–7904, 2000.
ista: Perroy J, Prezèau L, De Waard M, Shigemoto R, Bockaërt J, Fagni L. 2000. Selective
blockade of P/Q-type calcium channels by the metabotropic glutamate receptor type
7 involves a phospholipase C pathway in neurons. Journal of Neuroscience. 20(21),
7896–7904.
mla: Perroy, Julie, et al. “Selective Blockade of P/Q-Type Calcium Channels by the
Metabotropic Glutamate Receptor Type 7 Involves a Phospholipase C Pathway in Neurons.”
Journal of Neuroscience, vol. 20, no. 21, Society for Neuroscience, 2000,
pp. 7896–904, doi:10.1523/JNEUROSCI.20-21-07896.2000.
short: J. Perroy, L. Prezèau, M. De Waard, R. Shigemoto, J. Bockaërt, L. Fagni,
Journal of Neuroscience 20 (2000) 7896–7904.
date_created: 2018-12-11T11:58:37Z
date_published: 2000-11-01T00:00:00Z
date_updated: 2023-05-03T09:48:17Z
day: '01'
doi: 10.1523/JNEUROSCI.20-21-07896.2000
extern: '1'
external_id:
pmid:
- '11050109'
fulldoi: https://doi.org/10.1523/JNEUROSCI.20-21-07896.2000
intvolume: ' 20'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772734/
month: '11'
oa: 1
oa_version: Published Version
page: 7896 - 7904
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4296'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Selective blockade of P/Q-type calcium channels by the metabotropic glutamate
receptor type 7 involves a phospholipase C pathway in neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3489'
abstract:
- lang: eng
text: We have examined factors that determine the strength and dynamics of GABAergic
synapses between interneurons [dentate gyrus basket cells (BCs)] and principal
neurons [dentate gyrus granule cells (GCs)] using paired recordings in rat hippocampal
slices at 34°C. Unitary IPSCs recorded from BC–GC pairs in high intracellular
Cl− concentration showed a fast rise and a biexponential decay, with mean time
constants of 2 and 9 msec. The mean quantal conductance change, determined directly
at reduced extracellular Ca2+/Mg2+concentration ratios, was 1.7 nS. Quantal release
at the BC–GC synapse occurred with short delay and was highly synchronized. Analysis
of IPSC peak amplitudes and numbers of failures by multiple probability compound
binomial analysis indicated that synaptic transmission at the BC–GC synapse involves
three to seven release sites, each of which releases transmitter with high probability
(∼0.5 in 2 mMCa2+/1 mM Mg2+). Unitary BC–GC IPSCs showed paired-pulse depression
(PPD); maximal depression, measured for 10 msec intervals, was 37%, and recovery
from depression occurred with a time constant of 2 sec. Paired-pulse depression
was mainly presynaptic in origin but appeared to be independent of previous release.
Synaptic transmission at the BC–GC synapse showed frequency-dependent depression,
with half-maximal decrease at 5 Hz after a series of 1000 presynaptic action potentials.
The relative stability of transmission at the BC–GC synapse is consistent with
a model in which an activity-dependent gating mechanism reduces release probability
and thereby prevents depletion of the releasable pool of synaptic vesicles. Thus
several mechanisms converge on the generation of powerful and sustained transmission
at interneuron–principal neuron synapses in hippocampal circuits.
acknowledgement: This work was supported by grants from the Deutsche Forschungsgemeinschaft
(SFB 505/C5) and the Human Frontiers Science Program Organization (RG0017/1998-B)
to P.J. Novartis generously provided CGP55845A. We thank Drs. J. Bischofberger,
F. A. Edwards, J. R. P. Geiger, M. V. Jones, M. Martina, and A. Roth for critically
reading this manuscript. We also thank A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Kraushaar U, Jonas PM. Efficacy and stability of quantal GABA release at a
hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
2000;20(15):5594-5607. doi:10.1523/JNEUROSCI.20-15-05594.2000
apa: Kraushaar, U., & Jonas, P. M. (2000). Efficacy and stability of quantal
GABA release at a hippocampal interneuron-principal neuron synapse. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000
chicago: Kraushaar, Udo, and Peter M Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience. Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000.
ieee: U. Kraushaar and P. M. Jonas, “Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse,” Journal of Neuroscience,
vol. 20, no. 15. Society for Neuroscience, pp. 5594–5607, 2000.
ista: Kraushaar U, Jonas PM. 2000. Efficacy and stability of quantal GABA release
at a hippocampal interneuron-principal neuron synapse. Journal of Neuroscience.
20(15), 5594–5607.
mla: Kraushaar, Udo, and Peter M. Jonas. “Efficacy and Stability of Quantal GABA
Release at a Hippocampal Interneuron-Principal Neuron Synapse.” Journal of
Neuroscience, vol. 20, no. 15, Society for Neuroscience, 2000, pp. 5594–607,
doi:10.1523/JNEUROSCI.20-15-05594.2000.
short: U. Kraushaar, P.M. Jonas, Journal of Neuroscience 20 (2000) 5594–5607.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-08-01T00:00:00Z
date_updated: 2023-05-03T08:18:39Z
day: '01'
doi: 10.1523/JNEUROSCI.20-15-05594.2000
extern: '1'
external_id:
pmid:
- '10908596'
fulldoi: https://doi.org/10.1523/JNEUROSCI.20-15-05594.2000
intvolume: ' 20'
issue: '15'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6772523/
month: '08'
oa: 1
oa_version: Published Version
page: 5594 - 5607
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2898'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Efficacy and stability of quantal GABA release at a hippocampal interneuron-principal
neuron synapse
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '3490'
abstract:
- lang: eng
text: Long-term depression (LTD) is a form of synaptic plasticity that can be induced
either by low-frequency stimulation of presynaptic fibers or in an associative
manner by asynchronous pairing of presynaptic and postsynaptic activity. We investigated
the induction mechanisms of associative LTD in CA1 pyramidal neurons of the hippocampus
using whole-cell patch-clamp recordings and Ca2+ imaging in acute brain slices.
Asynchronous pairing of postsynaptic action potentials with EPSPs evoked with
a delay of 20 msec induced a robust, long-lasting depression of the EPSP amplitude
to 43%. Unlike LTD induced by low-frequency stimulation, associative LTD was resistant
to the application of D-AP-5, indicating that it is independent of NMDA receptors.
In contrast, associative LTD was inhibited by (S)-α-methyl-4-carboxyphenyl-glycine,
indicating the involvement of metabotropic glutamate receptors. Furthermore, associative
LTD is dependent on the activation of voltage-gated Ca2+ channels by postsynaptic
action potentials. Both nifedipine, an L-type Ca2+ channel antagonist, and ω-conotoxin
GVIA, a selective N-type channel blocker, abolished the induction of associative
LTD. 8-hydroxy-2-dipropylaminotetralin (OH-DPAT), a 5-HT(1A) receptor agonist,
inhibited postsynaptic Ca2+ influx through N-type Ca2+ channels, without affecting
presynaptic transmitter release. OH-DPAT also inhibited the induction of associative
LTD, suggesting that the involvement of N-type channels makes synaptic plasticity
accessible to modulation by neurotransmitters. Thus, the modulation of N-type
Ca2+ channels provides a gain control for synaptic depression in hippocampal pyramidal
neurons.
acknowledgement: This work was supported by a grant from the Deutsche Forschungsgemeinschaft
Bi 642/1–2 and University funds (J.B.) and by the Vada and Theodore Stanley Foundation
(J.W.). We thank Drs. M. Bartos, J. R. P. Geiger, and M. Martina for critically
reading this manuscript and A. Blomenkamp for technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Claus
full_name: Normann, Claus
last_name: Normann
- first_name: Diana
full_name: Peckys, Diana
last_name: Peckys
- first_name: Christian
full_name: Schulze, Christian
last_name: Schulze
- first_name: Jörg
full_name: Walden, Jörg
last_name: Walden
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Joseph
full_name: Bischofberger, Joseph
last_name: Bischofberger
citation:
ama: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. Associative
long-term depression in the hippocampus is dependent on postsynaptic N-type Ca(2+)
channels. Journal of Neuroscience. 2000;20(22):8290-8297. doi:10.1523/JNEUROSCI.20-22-08290.2000
apa: Normann, C., Peckys, D., Schulze, C., Walden, J., Jonas, P. M., & Bischofberger,
J. (2000). Associative long-term depression in the hippocampus is dependent on
postsynaptic N-type Ca(2+) channels. Journal of Neuroscience. Society for
Neuroscience. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000
chicago: Normann, Claus, Diana Peckys, Christian Schulze, Jörg Walden, Peter M Jonas,
and Joseph Bischofberger. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience.
Society for Neuroscience, 2000. https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000.
ieee: C. Normann, D. Peckys, C. Schulze, J. Walden, P. M. Jonas, and J. Bischofberger,
“Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels,” Journal of Neuroscience, vol. 20, no. 22. Society
for Neuroscience, pp. 8290–8297, 2000.
ista: Normann C, Peckys D, Schulze C, Walden J, Jonas PM, Bischofberger J. 2000.
Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels. Journal of Neuroscience. 20(22), 8290–8297.
mla: Normann, Claus, et al. “Associative Long-Term Depression in the Hippocampus
Is Dependent on Postsynaptic N-Type Ca(2+) Channels.” Journal of Neuroscience,
vol. 20, no. 22, Society for Neuroscience, 2000, pp. 8290–97, doi:10.1523/JNEUROSCI.20-22-08290.2000.
short: C. Normann, D. Peckys, C. Schulze, J. Walden, P.M. Jonas, J. Bischofberger,
Journal of Neuroscience 20 (2000) 8290–8297.
date_created: 2018-12-11T12:03:36Z
date_published: 2000-11-15T00:00:00Z
date_updated: 2023-05-03T08:02:52Z
day: '15'
doi: 10.1523/JNEUROSCI.20-22-08290.2000
extern: '1'
external_id:
pmid:
- '11069935'
fulldoi: https://doi.org/10.1523/JNEUROSCI.20-22-08290.2000
intvolume: ' 20'
issue: '22'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6773198/
month: '11'
oa: 1
oa_version: Published Version
page: 8290 - 8297
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2897'
quality_controlled: '1'
status: public
title: Associative long-term depression in the hippocampus is dependent on postsynaptic
N-type Ca(2+) channels
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 20
year: '2000'
...
---
_id: '2592'
abstract:
- lang: eng
text: Metabotropic glutamate receptors (mGluRs) consist of eight different subtypes
and exert their effects or second messengers and ion channels via G- proteins.
The function of individual mGluR subtypes in the CNS, however, largely remains
to be clarified. We examined the fear response of freezing after electric shock
in wild-type and mGluR7(-/-) knockout littermates. Wild- type mice displayed freezing
immediately after and 1 d after footshock. In comparison, mGluR7(-/-) knockout
mice showed significantly reduced levels in both immediate postshock and delayed
freezing responses. However, the knockout mice exhibited no abnormalities in pain
sensitivity and locomotor activity. To further examine amygdala-dependent behavior,
we performed conditioned taste aversion (CTA) experiments. In wild-type mice,
the administration of saccharin followed by intraperitoneal injection of the malaise-inducing
agent LiCl resulted in an association between saccharin and LiCl. This association
caused strong CTA toward saccharin n contrast, mGluR7(-/-) knockout mice failed
to associate between the taste and the negative reinforcer in CTA experiments.
Again, the knockout mice showed no abnormalities in taste preference and in the
sensitivity to LiCl toxicity. These results indicate that mGluR7 deficiency causes
an impairment of two distinct amygdala-dependent behavioral paradigms. Immunohistochemical
and immunoelectron-microscopic analyses showed that mGluR7 is highly expressed
in amygdala and preferentially localized at the presynaptic axon terminals of
glutamatergic neurons. Together, these findings strongly suggest that mGluR7 is
involved in neural processes subserving amygdala-dependent averse responses.
acknowledgement: This work was supported in part by research grants from the Ministry
of Education, Science and Culture of Japan, the Ministry of Health and Welfare of
Japan, the Sankyo Foundation, the Yamanouchi Foundation, and the Biomolecular Engineering
Research Institute. We thank Takashi Yamamoto for advice on CTA experiments, Fumitaka
Ushikubi for advice on the nociception test, Markus Schroeder for back-crossing
of mutant mice, Ayae Kinoshita for the kind gift of antibodies, Akira Uesugi for
photography, and Kumlesh K. Dev for careful reading of this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Miwako
full_name: Masugi, Miwako
last_name: Masugi
- first_name: Mineto
full_name: Yokoi, Mineto
last_name: Yokoi
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Keiko
full_name: Muguruma, Keiko
last_name: Muguruma
- first_name: Yasuyoshi
full_name: Watanabe, Yasuyoshi
last_name: Watanabe
- first_name: Gilles
full_name: Sansig, Gilles
last_name: Sansig
- first_name: Herman
full_name: Van Der Putten, Herman
last_name: Van Der Putten
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
citation:
ama: Masugi M, Yokoi M, Shigemoto R, et al. Metabotropic glutamate receptor subtype
7 ablation causes deficit in fear response and conditioned taste aversion. Journal
of Neuroscience. 1999;19(3):955-963. doi:10.1523/JNEUROSCI.19-03-00955.1999
apa: Masugi, M., Yokoi, M., Shigemoto, R., Muguruma, K., Watanabe, Y., Sansig, G.,
… Nakanishi, S. (1999). Metabotropic glutamate receptor subtype 7 ablation causes
deficit in fear response and conditioned taste aversion. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-03-00955.1999
chicago: Masugi, Miwako, Mineto Yokoi, Ryuichi Shigemoto, Keiko Muguruma, Yasuyoshi
Watanabe, Gilles Sansig, Herman Van Der Putten, and Shigetada Nakanishi. “Metabotropic
Glutamate Receptor Subtype 7 Ablation Causes Deficit in Fear Response and Conditioned
Taste Aversion.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-03-00955.1999.
ieee: M. Masugi et al., “Metabotropic glutamate receptor subtype 7 ablation
causes deficit in fear response and conditioned taste aversion,” Journal of
Neuroscience, vol. 19, no. 3. Society for Neuroscience, pp. 955–963, 1999.
ista: Masugi M, Yokoi M, Shigemoto R, Muguruma K, Watanabe Y, Sansig G, Van Der
Putten H, Nakanishi S. 1999. Metabotropic glutamate receptor subtype 7 ablation
causes deficit in fear response and conditioned taste aversion. Journal of Neuroscience.
19(3), 955–963.
mla: Masugi, Miwako, et al. “Metabotropic Glutamate Receptor Subtype 7 Ablation
Causes Deficit in Fear Response and Conditioned Taste Aversion.” Journal of
Neuroscience, vol. 19, no. 3, Society for Neuroscience, 1999, pp. 955–63,
doi:10.1523/JNEUROSCI.19-03-00955.1999.
short: M. Masugi, M. Yokoi, R. Shigemoto, K. Muguruma, Y. Watanabe, G. Sansig, H.
Van Der Putten, S. Nakanishi, Journal of Neuroscience 19 (1999) 955–963.
date_created: 2018-12-11T11:58:33Z
date_published: 1999-02-01T00:00:00Z
date_updated: 2023-03-27T10:00:42Z
day: '01'
doi: 10.1523/JNEUROSCI.19-03-00955.1999
extern: '1'
external_id:
pmid:
- '9920659'
fulldoi: https://doi.org/10.1523/JNEUROSCI.19-03-00955.1999
intvolume: ' 19'
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782134/
month: '02'
oa: 1
oa_version: Published Version
page: 955 - 963
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4306'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Metabotropic glutamate receptor subtype 7 ablation causes deficit in fear response
and conditioned taste aversion
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '2593'
abstract:
- lang: eng
text: In cat and monkey, lamina I cells can be classified into three basic morphological
types (fusiform, pyramidal, and multipolar), and recent intracellular labeling
evidence in the cat indicates that fusiform and multipolar lamina I cells are
two different types of nociceptive cells, whereas pyramidal cells are innocuous
thermoreceptive-specific. Because earlier observations indicated that only nociceptive
dorsal horn neurons respond to substance P (SP), we examined which morphological
types of lamina I neurons express receptors for SP (NK-1r). We categorized NK-1r-
immunoreactive (IR) lamina I neurons in serial horizontal sections from the cervical
and lumbar enlargements of four monkeys. Consistent results were obtained by two
independent teams of observers. Nearly all NK-1r-IR cells were fusiform (42%)
or multipolar (43%), but only 6% were pyramidal (with 9% unclassified). We obtained
similar findings in three monkeys in which we used double-labeling immunocytochemistry
to identify NK-1r-IR and spinothalamic lamina I neurons retrogradely labeled with
cholera toxin subunit b from the thalamus; most NK-1r-IR lamina I spinothalamic
neurons were fusiform (48%) or multipolar (33%), and only 10% were pyramidal.
In contrast, most (~75%) pyramidal and some (~25%) fusiform and multipolar lamina
I spinothalamic neurons did not display NK-1r immunoreactivity. These data indicate
that most fusiform and multipolar lamina I neurons in the monkey can express NK-1r,
consistent with the idea that both types are nociceptive, whereas only a small
proportion of lamina I pyramidal cells express this receptor, consistent with
the previous finding that they are nonnociceptive. However, these findings also
indicate that not all nociceptive lamina I neurons express receptors for SP.
acknowledgement: This study was supported by National Institute of Health Grants NS
34022 to Y.D.K. and NS 25616 to A.D.C., by Canadian Medical Research Council (MRC)
Grants MT 12942 to Y.D.K. and MT 12170 to A.R.S., and by the Barrow Neurological
Foundation. Y.D.K. is a Scholar of the Canadian MRC. We thank A. Constantin and
A. Forster for expert technical assistance and Dr. M. Wikstrom for generously supplying
monoclonal antibodies against CTb.
article_processing_charge: No
article_type: original
author:
- first_name: Xiao
full_name: Yu, Xiao
last_name: Yu
- first_name: En
full_name: Zhang, En
last_name: Zhang
- first_name: Arthur
full_name: Craig, Arthur
last_name: Craig
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alfredo
full_name: Ribeiro Da Silva, Alfredo
last_name: Ribeiro Da Silva
- first_name: Yves
full_name: De Koninck, Yves
last_name: De Koninck
citation:
ama: Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. NK-1
receptor immunoreactivity in distinct morphological types of lamina I neurons
of the primate spinal cord. Journal of Neuroscience. 1999;19(9):3545-3555.
doi:10.1523/JNEUROSCI.19-09-03545.1999
apa: Yu, X., Zhang, E., Craig, A., Shigemoto, R., Ribeiro Da Silva, A., & De
Koninck, Y. (1999). NK-1 receptor immunoreactivity in distinct morphological types
of lamina I neurons of the primate spinal cord. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999
chicago: Yu, Xiao, En Zhang, Arthur Craig, Ryuichi Shigemoto, Alfredo Ribeiro Da
Silva, and Yves De Koninck. “NK-1 Receptor Immunoreactivity in Distinct Morphological
Types of Lamina I Neurons of the Primate Spinal Cord.” Journal of Neuroscience.
Society for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999.
ieee: X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, and Y. De Koninck,
“NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons
of the primate spinal cord,” Journal of Neuroscience, vol. 19, no. 9. Society
for Neuroscience, pp. 3545–3555, 1999.
ista: Yu X, Zhang E, Craig A, Shigemoto R, Ribeiro Da Silva A, De Koninck Y. 1999.
NK-1 receptor immunoreactivity in distinct morphological types of lamina I neurons
of the primate spinal cord. Journal of Neuroscience. 19(9), 3545–3555.
mla: Yu, Xiao, et al. “NK-1 Receptor Immunoreactivity in Distinct Morphological
Types of Lamina I Neurons of the Primate Spinal Cord.” Journal of Neuroscience,
vol. 19, no. 9, Society for Neuroscience, 1999, pp. 3545–55, doi:10.1523/JNEUROSCI.19-09-03545.1999.
short: X. Yu, E. Zhang, A. Craig, R. Shigemoto, A. Ribeiro Da Silva, Y. De Koninck,
Journal of Neuroscience 19 (1999) 3545–3555.
date_created: 2018-12-11T11:58:34Z
date_published: 1999-05-01T00:00:00Z
date_updated: 2023-03-27T09:54:40Z
day: '01'
doi: 10.1523/JNEUROSCI.19-09-03545.1999
extern: '1'
external_id:
pmid:
- '10212314'
fulldoi: https://doi.org/10.1523/JNEUROSCI.19-09-03545.1999
intvolume: ' 19'
issue: '9'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782224/
month: '05'
oa: 1
oa_version: None
page: 3545 - 3555
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4305'
quality_controlled: '1'
scopus_import: '1'
status: public
title: NK-1 receptor immunoreactivity in distinct morphological types of lamina I
neurons of the primate spinal cord
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3148'
abstract:
- lang: eng
text: Accurate proteolytic processing of neuropeptide and peptide hormone precursors
by members of the kexin/furin family of proteases is key to determining both the
identities and activities of signaling peptides. Here we identify amontillado
(amon), the Drosophila melanogaster homolog of the mammalian neuropeptide processing
protease PC2, and show that in contrast to vertebrate PC2, amontillado expression
undergoes extensive regulation in the nervous system during development. In situ
hybridization reveals that expression of amontillado is restricted to the final
stages of embryogenesis when it is found in anterior sensory structures and in
only 168 cells in the brain and ventral nerve cord. After larvae hatch from their
egg shells, the sensory structures and most cells in the CNS turn off or substantially
reduce amontillado expression, suggesting that amontillado plays a specific role
late in embryogenesis. Larvae lacking the chromosomal region containing amontillado
show no gross anatomical defects and respond to touch. However, such larvae show
a greatly reduced frequency of a hatching behavior of wild- type Drosophila in
which larvae swing their heads, scraping through the eggshell with their mouth
hooks. Ubiquitous expression of amontillado can restore near wild-type levels
of this behavior, whereas expression of amontillado with an alanine substitution
for the catalytic histidine cannot. These results suggest that amontillado expression
is regulated as part of a programmed modulation of neural signaling that controls
hatching behavior by producing specific neuropeptides in particular neurons at
an appropriate developmental time.
acknowledgement: This research was supported by National Institutes of Health Grant
GM39697 to R.S.F. D.S. was supported in part by National Institutes of Health training
Grant 2T32GM07599. We thank M. A. Krasnow and members of his laboratory, particularly
J. Jarecki, for technical guidance, encouragement, and stimulating scientific discussions.
We thank A. Maghbouleh and the Stanford Statistics Department Consulting Service
for help with statistical analysis. We thank G. Beitel, S. Dietrich, K. Guillemin,
D. Micklem, Y. Nakajima, and members of the Fuller and Krasnow laboratories for
comments on this manuscript. We thank M. Palazzolo for the use of theDrosophila
head cDNA library, D. Kiehart for the use of a Drosophila myosin antibody, and D.
Casso, F.-A. Ramirez-Weber, and T. B. Kornberg for use of the D/TM3SbKrGFP flies.
We thank A. R. Kidd, D. Tolla, and M. Bender and D. Casso, F.-A. Ramirez-Weber and
T. B. Kornberg for communication of results before publication
article_processing_charge: No
article_type: original
author:
- first_name: Daria E
full_name: Siekhaus, Daria E
id: 3D224B9E-F248-11E8-B48F-1D18A9856A87
last_name: Siekhaus
orcid: 0000-0001-8323-8353
- first_name: Robert
full_name: Fuller, Robert
last_name: Fuller
citation:
ama: Siekhaus DE, Fuller R. A role for amontillado the Drosophila homolog of the
neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 1999;19(16):6942-6954. doi:10.1523/jneurosci.19-16-06942.1999
apa: Siekhaus, D. E., & Fuller, R. (1999). A role for amontillado the Drosophila
homolog of the neuropeptide precursor processing protease PC2 in triggering hatching
behavior. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/jneurosci.19-16-06942.1999
chicago: Siekhaus, Daria E, and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience. Society for Neuroscience, 1999. https://doi.org/10.1523/jneurosci.19-16-06942.1999.
ieee: D. E. Siekhaus and R. Fuller, “A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior,”
Journal of Neuroscience, vol. 19, no. 16. Society for Neuroscience, pp.
6942–6954, 1999.
ista: Siekhaus DE, Fuller R. 1999. A role for amontillado the Drosophila homolog
of the neuropeptide precursor processing protease PC2 in triggering hatching behavior.
Journal of Neuroscience. 19(16), 6942–6954.
mla: Siekhaus, Daria E., and Robert Fuller. “A Role for Amontillado the Drosophila
Homolog of the Neuropeptide Precursor Processing Protease PC2 in Triggering Hatching
Behavior.” Journal of Neuroscience, vol. 19, no. 16, Society for Neuroscience,
1999, pp. 6942–54, doi:10.1523/jneurosci.19-16-06942.1999.
short: D.E. Siekhaus, R. Fuller, Journal of Neuroscience 19 (1999) 6942–6954.
date_created: 2018-12-11T12:01:40Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:48:41Z
day: '15'
doi: 10.1523/jneurosci.19-16-06942.1999
extern: '1'
external_id:
pmid:
- '10436051 '
fulldoi: https://doi.org/10.1523/jneurosci.19-16-06942.1999
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782853/
month: '08'
oa: 1
oa_version: Published Version
page: 6942 - 6954
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '3547'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A role for amontillado the Drosophila homolog of the neuropeptide precursor
processing protease PC2 in triggering hatching behavior
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3444'
abstract:
- lang: eng
text: This study examined intermittent, high-frequency (100-200 Hz) oscillatory
patterns in the CA1 region of the hippocampus in the absence of theta activity,
i.e., during and in between sharp wave (SPW) bursts. Pyramidal and interneuronal
activity was phase-locked not only to large amplitude (>7 SD from baseline)
oscillatory events, which are present mainly during SPWs, but to smaller amplitude
(<4 SD) patterns, as well. Large-amplitude events were in the 140-200 Hz, "ripple"
frequency range. Lower-amplitude events, however, contained slower, 100-130 Hz
("slow") oscillatory patterns. Fast ripple waves reversed just below
the CA1 pyramidal layer, whereas slow oscillatory potentials reversed in the stratum
radiatum and/or in the stratum oriens. Parallel CA1-CA3 recordings revealed correlated
CA3 field and unit activity to the slow CA1 waves but not to fast ripple waves.
These findings suggest that fast ripples emerge in the CA1 region, whereas slow
(100-130 Hz) oscillatory patterns are generated in the CA3 region and transferred
to the CA1 field.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Fast network oscillations
in the hippocampal CA1 region of the behaving rat. Journal of Neuroscience.
1999;19(16). doi:10.1523/JNEUROSCI.19-16-j0001.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Fast network oscillations in the hippocampal CA1 region of the behaving rat.
Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Fast Network Oscillations in the Hippocampal CA1 Region of the
Behaving Rat.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Fast network
oscillations in the hippocampal CA1 region of the behaving rat,” Journal
of Neuroscience, vol. 19, no. 16. Society for Neuroscience, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Fast network
oscillations in the hippocampal CA1 region of the behaving rat. Journal of
Neuroscience. 19(16).
mla: Csicsvari, Jozsef L., et al. “Fast Network Oscillations in the Hippocampal
CA1 Region of the Behaving Rat.” Journal of Neuroscience, vol. 19, no.
16, Society for Neuroscience, 1999, doi:10.1523/JNEUROSCI.19-16-j0001.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999).
date_created: 2018-12-11T12:03:22Z
date_published: 1999-08-15T00:00:00Z
date_updated: 2022-09-07T13:41:18Z
day: '15'
doi: 10.1523/JNEUROSCI.19-16-j0001.1999
extern: '1'
external_id:
pmid:
- '10436076'
fulldoi: https://doi.org/10.1523/JNEUROSCI.19-16-j0001.1999
intvolume: ' 19'
issue: '16'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782850/
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Fast network oscillations in the hippocampal CA1 region of the behaving
rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3445'
abstract:
- lang: eng
text: The medial septal region and the hippocampus are connected reciprocally via
GABAergic neurons, but the physiological role of this loop is still not well understood.
In an attempt to reveal the physiological effects of the hippocamposeptal GABAergic
projection, we cross-correlated hippocampal sharp wave (SPW) ripples or theta
activity and extracellular units recorded in the medial septum and diagonal band
of Broca (MSDB) in freely moving rats. The majority of single MSDB cells (60%)
were significantly suppressed during SPWs. Most cells inhibited during SPW (80%)
fired rhythmically and phase-locked to the negative peak of the CA1 pyramidal
layer theta waves. Because both SPW and the negative peak of local theta waves
correspond to the maximum discharge probability of CA1 pyramidal cells and interneuron
classes, the findings indicate that the activity of medial septal neurons can
be negatively (during SPW) or positively (during theta waves) correlated with
the activity of hippocampal interneurons. We hypothesize that the functional coupling
between medial septal neurons and hippocampal interneurons varies in a state-dependent
manner.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671. We thank Z. Borhegyi, H. Hirase, C. King, and Z. Nadásdy for help and
support and T. F. Freund for his comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: George
full_name: Dragoi, George
last_name: Dragoi
- first_name: Daniel
full_name: Carpi, Daniel
last_name: Carpi
- first_name: Michael
full_name: Recce, Michael
last_name: Recce
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. Interactions between hippocampus
and medial septum during sharp waves and theta oscillation in the behaving rat.
Journal of Neuroscience. 1999;19(14):6191-6199. doi:10.1523/JNEUROSCI.19-14-06191.1999
apa: Dragoi, G., Carpi, D., Recce, M., Csicsvari, J. L., & Buzsáki, G. (1999).
Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
chicago: Dragoi, George, Daniel Carpi, Michael Recce, Jozsef L Csicsvari, and György
Buzsáki. “Interactions between Hippocampus and Medial Septum during Sharp Waves
and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience. Society
for Neuroscience, 1999. https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999.
ieee: G. Dragoi, D. Carpi, M. Recce, J. L. Csicsvari, and G. Buzsáki, “Interactions
between hippocampus and medial septum during sharp waves and theta oscillation
in the behaving rat,” Journal of Neuroscience, vol. 19, no. 14. Society
for Neuroscience, pp. 6191–6199, 1999.
ista: Dragoi G, Carpi D, Recce M, Csicsvari JL, Buzsáki G. 1999. Interactions between
hippocampus and medial septum during sharp waves and theta oscillation in the
behaving rat. Journal of Neuroscience. 19(14), 6191–6199.
mla: Dragoi, George, et al. “Interactions between Hippocampus and Medial Septum
during Sharp Waves and Theta Oscillation in the Behaving Rat.” Journal of Neuroscience,
vol. 19, no. 14, Society for Neuroscience, 1999, pp. 6191–99, doi:10.1523/JNEUROSCI.19-14-06191.1999.
short: G. Dragoi, D. Carpi, M. Recce, J.L. Csicsvari, G. Buzsáki, Journal of Neuroscience
19 (1999) 6191–6199.
date_created: 2018-12-11T12:03:22Z
date_published: 1999-07-15T00:00:00Z
date_updated: 2022-09-07T13:37:41Z
day: '15'
doi: 10.1523/JNEUROSCI.19-14-06191.1999
extern: '1'
external_id:
pmid:
- '10407055'
fulldoi: https://doi.org/10.1523/JNEUROSCI.19-14-06191.1999
intvolume: ' 19'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6783073/
month: '07'
oa: 1
oa_version: Published Version
page: 6191 - 6199
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2942'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Interactions between hippocampus and medial septum during sharp waves and theta
oscillation in the behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3518'
abstract:
- lang: eng
text: Information in neuronal networks may be represented by the spatiotemporal
patterns of spikes. Here we examined the temporal coordination of pyramidal cell
spikes in the rat hippocampus during slow-wave sleep. In addition, rats were trained
to run in a defined position in space (running wheel) to activate a selected group
of pyramidal cells. A template-matching method and a joint probability map method
were used for sequence search. Repeating spike sequences in excess of chance occurrence
were examined by comparing the number of repeating sequences in the original spike
trains and in surrogate trains after Monte Carlo shuffling of the spikes. Four
different shuffling procedures were used to control for the population dynamics
of hippocampal neurons. Repeating spike sequences in the recorded cell assemblies
were present in both the awake and sleeping animal in excess of what might be
predicted by random variations. Spike sequences observed during wheel running
were “replayed” at a faster timescale during single sharp-wave bursts of slow-wave
sleep. We hypothesize that the endogenously expressed spike sequences during sleep
reflect reactivation of the circuitry modified by previous experience. Reactivation
of acquired sequences may serve to consolidate information.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994
and MH54671 and by the Human Science Frontier Program. We thank Moshe Abeles, Michale
Fee, Stuart Geman, Stephen Hanson, Darrell Henze, Günther Palm, Michael Recce, and
Matthew Wilson for their suggestions with data analysis and comments on this manuscript.
article_processing_charge: No
article_type: original
author:
- first_name: Zoltán
full_name: Nádasdy, Zoltán
last_name: Nádasdy
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. Replay and time compression
of recurring spike sequences in the hippocampus. Journal of Neuroscience.
1999;19(21):9497-9507. doi:10.1523/JNEUROSCI.19-21-09497.1999
apa: Nádasdy, Z., Hirase, H., Czurkó, A., Csicsvari, J. L., & Buzsáki, G. (1999).
Replay and time compression of recurring spike sequences in the hippocampus. Journal
of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
chicago: Nádasdy, Zoltán, Hajima Hirase, András Czurkó, Jozsef L Csicsvari, and
György Buzsáki. “Replay and Time Compression of Recurring Spike Sequences in the
Hippocampus.” Journal of Neuroscience. Society for Neuroscience, 1999.
https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999.
ieee: Z. Nádasdy, H. Hirase, A. Czurkó, J. L. Csicsvari, and G. Buzsáki, “Replay
and time compression of recurring spike sequences in the hippocampus,” Journal
of Neuroscience, vol. 19, no. 21. Society for Neuroscience, pp. 9497–9507,
1999.
ista: Nádasdy Z, Hirase H, Czurkó A, Csicsvari JL, Buzsáki G. 1999. Replay and time
compression of recurring spike sequences in the hippocampus. Journal of Neuroscience.
19(21), 9497–9507.
mla: Nádasdy, Zoltán, et al. “Replay and Time Compression of Recurring Spike Sequences
in the Hippocampus.” Journal of Neuroscience, vol. 19, no. 21, Society
for Neuroscience, 1999, pp. 9497–507, doi:10.1523/JNEUROSCI.19-21-09497.1999.
short: Z. Nádasdy, H. Hirase, A. Czurkó, J.L. Csicsvari, G. Buzsáki, Journal of
Neuroscience 19 (1999) 9497–9507.
date_created: 2018-12-11T12:03:45Z
date_published: 1999-11-01T00:00:00Z
date_updated: 2022-09-07T12:48:08Z
day: '01'
doi: 10.1523/JNEUROSCI.19-21-09497.1999
extern: '1'
external_id:
pmid:
- '10531452'
fulldoi: https://doi.org/10.1523/JNEUROSCI.19-21-09497.1999
intvolume: ' 19'
issue: '21'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782894/
month: '11'
oa: 1
oa_version: Published Version
page: 9497 - 9507
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2866'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Replay and time compression of recurring spike sequences in the hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3524'
abstract:
- lang: eng
text: We examined whether excitation and inhibition are balanced in hippocampal
cortical networks. Extracellular field and single-unit activity were recorded
by multiple tetrodes and multisite silicon probes to reveal the timing of the
activity of hippocampal CAI pyramidal cells and classes of interneurons during
theta waves and sharp wave burst (SPW)-associated field ripples. The somatic and
dendritic inhibition of pyramidal cells was deduced from the activity of interneurons
in the pyramidal layer [int(p)] and in the alveus and st. oriens [int(a/o)], respectively.
int(p) and int(a/o) discharged an average of 60 and 20 degrees before the population
discharge of pyramidal cells during the theta cycle, respectively. SPW ripples
were associated with a 2.5-fold net increase of excitation. The discharge frequency
of int(a/o) increased, decreased (”anti-SPW” cells), or did not change (”SPW-independent”
cells) during SPW suggesting that not all interneurons are innervated by pyramidal
cells. Int(p) either fired together with (unimodal cells) or both before and after
(bimodal cells) the pyramidal cell burst. During fast-ripple oscillation, the
activity of interneurons in both the int(p) and int(a/o) groups lagged the maximum
discharge probability of pyramidal neurons by 1-2 msec. Network state changes,
as reflected by field activity, covaried with changes in the spike train dynamics
of single cells and their interactions. Summed activity of parallel-recorded interneurons,
but not of pyramidal cells, reliably predicted theta cycles, whereas the reverse
was true for the ripple cycles of SPWs. We suggest that network-driven excitability
changes provide temporal windows of opportunity for single pyramidal cells to
suppress, enable, or facilitate selective synaptic inputs.
acknowledgement: This work was supported by National Institutes of Health Grants NS34994,
MH54671, and 1P41RR09754 and by the Human Frontier Science Program. We thank Darrell
A. Henze and M. Recce for their comments on this manuscript and Jamie Hetke and
Ken Wise for supplying us with silicon probes.
article_processing_charge: No
article_type: original
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Hajima
full_name: Hirase, Hajima
last_name: Hirase
- first_name: András
full_name: Czurkó, András
last_name: Czurkó
- first_name: Akira
full_name: Mamiya, Akira
last_name: Mamiya
- first_name: György
full_name: Buzsáki, György
last_name: Buzsáki
citation:
ama: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal
of Neuroscience. 1999;19(1):274-287. doi:10.1523/JNEUROSCI.19-01-00274.1999
apa: Csicsvari, J. L., Hirase, H., Czurkó, A., Mamiya, A., & Buzsáki, G. (1999).
Oscillatory coupling of hippocampal pyramidal cells and interneurons in the behaving
rat. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
chicago: Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, Akira Mamiya, and György
Buzsáki. “Oscillatory Coupling of Hippocampal Pyramidal Cells and Interneurons
in the Behaving Rat.” Journal of Neuroscience. Society for Neuroscience,
1999. https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999.
ieee: J. L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, and G. Buzsáki, “Oscillatory
coupling of hippocampal pyramidal cells and interneurons in the behaving rat,”
Journal of Neuroscience, vol. 19, no. 1. Society for Neuroscience, pp.
274–287, 1999.
ista: Csicsvari JL, Hirase H, Czurkó A, Mamiya A, Buzsáki G. 1999. Oscillatory coupling
of hippocampal pyramidal cells and interneurons in the behaving rat. Journal of
Neuroscience. 19(1), 274–287.
mla: Csicsvari, Jozsef L., et al. “Oscillatory Coupling of Hippocampal Pyramidal
Cells and Interneurons in the Behaving Rat.” Journal of Neuroscience, vol.
19, no. 1, Society for Neuroscience, 1999, pp. 274–87, doi:10.1523/JNEUROSCI.19-01-00274.1999.
short: J.L. Csicsvari, H. Hirase, A. Czurkó, A. Mamiya, G. Buzsáki, Journal of Neuroscience
19 (1999) 274–287.
date_created: 2018-12-11T12:03:47Z
date_published: 1999-01-01T00:00:00Z
date_updated: 2022-09-07T10:00:45Z
day: '01'
doi: 10.1523/JNEUROSCI.19-01-00274.1999
extern: '1'
external_id:
pmid:
- '9870957'
fulldoi: https://doi.org/10.1523/JNEUROSCI.19-01-00274.1999
intvolume: ' 19'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6782375/
month: '01'
oa: 1
oa_version: Published Version
page: 274 - 287
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2860'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oscillatory coupling of hippocampal pyramidal cells and interneurons in the
behaving rat
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 19
year: '1999'
...
---
_id: '3488'
abstract:
- lang: eng
text: We have examined gating and pharmacological characteristics of somatic K+
channels in fast-spiking interneurons and regularly spiking principal neurons
of hippocampal slices. In nucleated patches isolated from basket cells of the
dentate gyrus, a fast delayed rectifier K+ current component that was highly sensitive
to tetraethylammonium (TEA) and 4-aminopyridine (4- AP) (half-maximal inhibitory
concentrations <0.1 mM) predominated, contributing an average of 58% to the
total K+ current in these cells. By contrast, in pyramidal neurons of the CA1
region a rapidly inactivating A- type K+ current component that was TEA-resistant
prevailed, contributing 61% to the total K+ current. Both types of neurons also
showed small amounts of the K+ current component mainly found in the other type
of neuron and, in addition, a slow delayed rectifier K+ current component with
intermediate properties (sow inactivation, intermediate sensitivity to TEA). Single-cell
RT-PCR analysis of mRNA revealed that Kv3 (Kv3.1, Kv3.2) subunit transcripts were
expressed in almost all (89%) of the interneurons but only in 17% of the pyramidal
neurons. In contrast, Kv4 (Kv4.2, Kv4.3) subunit mRNAs were present in 87% of
pyramidal neurons but only in 55% of interneurons. Selective block of fast delayed
rectifier K+ channels, presumably assembled from Kv3 subunits, by 4-AP reduced
substantially the action potential frequency in interneurons. These results indicate
that the differential expression of Kv3 and Kv4 subunits shapes the action potential
phenotypes of principal neurons and interneurons in the cortex.
acknowledgement: Supported by German Israeli Foundation Grant I 0352–073.01/94 to
P.J. and Deutsche Forschungsgemeinschaft Grant Mo 432/3–1 to H.M. We thank Drs.
L. Y. Jan, D. McKinnon, O. Pongs, L. Salkoff, S. H. Snyder, and J. S. Trimmer for
providing plasmids, Dr. D. J. Surmeier for sharing unpublished data, and Drs. J.
Bischofberger and J. R. P. Geiger for critically reading this manuscript. M.M. and
J.H.S. contributed equally to this work.
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Martina, Marco
last_name: Martina
- first_name: Jobst
full_name: Schultz, Jobst
last_name: Schultz
- first_name: Heimo
full_name: Ehmke, Heimo
last_name: Ehmke
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. Functional and molecular
differences between voltage-gated K+ channels of fast-spiking interneurons and
pyramidal neurons of rat hippocampus. Journal of Neuroscience. 1998;18(20):8111-8125.
doi:10.1523/JNEUROSCI.18-20-08111.1998
apa: Martina, M., Schultz, J., Ehmke, H., Monyer, H., & Jonas, P. M. (1998).
Functional and molecular differences between voltage-gated K+ channels of fast-spiking
interneurons and pyramidal neurons of rat hippocampus. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998
chicago: Martina, Marco, Jobst Schultz, Heimo Ehmke, Hannah Monyer, and Peter M
Jonas. “Functional and Molecular Differences between Voltage-Gated K+ Channels
of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1998. https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998.
ieee: M. Martina, J. Schultz, H. Ehmke, H. Monyer, and P. M. Jonas, “Functional
and molecular differences between voltage-gated K+ channels of fast-spiking interneurons
and pyramidal neurons of rat hippocampus,” Journal of Neuroscience, vol.
18, no. 20. Society for Neuroscience, pp. 8111–8125, 1998.
ista: Martina M, Schultz J, Ehmke H, Monyer H, Jonas PM. 1998. Functional and molecular
differences between voltage-gated K+ channels of fast-spiking interneurons and
pyramidal neurons of rat hippocampus. Journal of Neuroscience. 18(20), 8111–8125.
mla: Martina, Marco, et al. “Functional and Molecular Differences between Voltage-Gated
K+ Channels of Fast-Spiking Interneurons and Pyramidal Neurons of Rat Hippocampus.”
Journal of Neuroscience, vol. 18, no. 20, Society for Neuroscience, 1998,
pp. 8111–25, doi:10.1523/JNEUROSCI.18-20-08111.1998.
short: M. Martina, J. Schultz, H. Ehmke, H. Monyer, P.M. Jonas, Journal of Neuroscience
18 (1998) 8111–8125.
date_created: 2018-12-11T12:03:35Z
date_published: 1998-10-15T00:00:00Z
date_updated: 2022-08-29T14:20:39Z
day: '15'
doi: 10.1523/JNEUROSCI.18-20-08111.1998
extern: '1'
external_id:
pmid:
- '9763458'
fulldoi: https://doi.org/10.1523/JNEUROSCI.18-20-08111.1998
intvolume: ' 18'
issue: '20'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792860/
month: '10'
oa: 1
oa_version: None
page: 8111 - 8125
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2899'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional and molecular differences between voltage-gated K+ channels of fast-spiking
interneurons and pyramidal neurons of rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 18
year: '1998'
...
---
_id: '2582'
abstract:
- lang: eng
text: 'Neurotransmission in the hippocampus is modulated variously through presynaptic
metabotropic glutamate receptors (mGluRs). To establish the precise localization
of presynaptic mGluRs in the rat hippocampus, we used subtype-specific antibodies
for eight mGluRs (mGluR1-mGluR8) for immunohistochemistry combined with lesioning
of the three major hippocampal pathways: the perforant path, mossy fiber, and
Schaffer collateral. Immunoreactivity for group II (mGluR2) and group III (mGluR4a,
mGluR7a, mGluR7b, and mGluR8) mGluRs was predominantly localized to presynaptic
elements, whereas that for group I mGluRs (mGluR1 and mGluR5) was localized to
postsynaptic elements. The medial perforant path was strongly immunoreactive for
mGluR2 and mGluR7a throughout the hippocampus, and the lateral perforant path
was prominently immunoreactive for mGluR8 in the dentate gyrus and CA3 area. The
messy fiber was labeled for mGluR2, mGluR7a, and mGluR7b, whereas the Schaffer
collateral was labeled only for mGluR7a. Electron microscopy further revealed
the spatial segregation of group II and group III mGluRs within presynaptic elements.
Immunolabeling for the group III receptors was predominantly observed in presynaptic
active zones of asymmetrical and symmetrical synapses, whereas that for the group
II receptor (mGluR2) was found in preterminal rather than terminal portions of
axons. Target cell-specific segregation of receptors, first reported for mGluR7a
(Shigemoto et al., 1996), was also apparent for the other group III mGluRs, suggesting
that transmitter release is differentially regulated by 2-amino- 4-phosphonobutyrate-sensitive
mGluRs in individual synapses on single axons according to the identity of postsynaptic
neurons.'
acknowledgement: This work was supported by research grants from the Inamori Foundation
and the Ministry of Education, Science, Sports and Culture of Japan. We thank Peter
Somogyi for helpful discussion, David Roberts for technical assistance, and Akira
Uesugi for photographic assistance. We are grateful to Atsu Aiba, David Hampson,
John Roder, and Herman van der Putten for providing us with mGluR1-, mGluR4-, mGluR5-,
and mGluR7-deficient mice, respectively, and to Corrado Corti and Francesco Ferraguti
for sharing rat mGluR8 cDNA and unpublished results.
article_processing_charge: No
article_type: original
author:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ayae
full_name: Kinoshita, Ayae
last_name: Kinoshita
- first_name: Eiki
full_name: Wada, Eiki
last_name: Wada
- first_name: Sakashi
full_name: Nomura, Sakashi
last_name: Nomura
- first_name: Hitoshi
full_name: Ohishi, Hitoshi
last_name: Ohishi
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
- first_name: Peter
full_name: Flor, Peter
last_name: Flor
- first_name: Akio
full_name: Neki, Akio
last_name: Neki
- first_name: Takaaki
full_name: Abe, Takaaki
last_name: Abe
- first_name: Shigetada
full_name: Nakanishi, Shigetada
last_name: Nakanishi
- first_name: Noboru
full_name: Mizuno, Noboru
last_name: Mizuno
citation:
ama: Shigemoto R, Kinoshita A, Wada E, et al. Differential presynaptic localization
of metabotropic glutamate receptor subtypes in the rat hippocampus. Journal
of Neuroscience. 1997;17(19):7503-7522. doi:10.1523/JNEUROSCI.17-19-07503.1997
apa: Shigemoto, R., Kinoshita, A., Wada, E., Nomura, S., Ohishi, H., Takada, M.,
… Mizuno, N. (1997). Differential presynaptic localization of metabotropic glutamate
receptor subtypes in the rat hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997
chicago: Shigemoto, Ryuichi, Ayae Kinoshita, Eiki Wada, Sakashi Nomura, Hitoshi
Ohishi, Masahiko Takada, Peter Flor, et al. “Differential Presynaptic Localization
of Metabotropic Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal
of Neuroscience. Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997.
ieee: R. Shigemoto et al., “Differential presynaptic localization of metabotropic
glutamate receptor subtypes in the rat hippocampus,” Journal of Neuroscience,
vol. 17, no. 19. Society for Neuroscience, pp. 7503–7522, 1997.
ista: Shigemoto R, Kinoshita A, Wada E, Nomura S, Ohishi H, Takada M, Flor P, Neki
A, Abe T, Nakanishi S, Mizuno N. 1997. Differential presynaptic localization of
metabotropic glutamate receptor subtypes in the rat hippocampus. Journal of Neuroscience.
17(19), 7503–7522.
mla: Shigemoto, Ryuichi, et al. “Differential Presynaptic Localization of Metabotropic
Glutamate Receptor Subtypes in the Rat Hippocampus.” Journal of Neuroscience,
vol. 17, no. 19, Society for Neuroscience, 1997, pp. 7503–22, doi:10.1523/JNEUROSCI.17-19-07503.1997.
short: R. Shigemoto, A. Kinoshita, E. Wada, S. Nomura, H. Ohishi, M. Takada, P.
Flor, A. Neki, T. Abe, S. Nakanishi, N. Mizuno, Journal of Neuroscience 17 (1997)
7503–7522.
date_created: 2018-12-11T11:58:30Z
date_published: 1997-10-01T00:00:00Z
date_updated: 2022-08-22T11:32:01Z
day: '01'
doi: 10.1523/JNEUROSCI.17-19-07503.1997
extern: '1'
external_id:
pmid:
- '9295396'
fulldoi: https://doi.org/10.1523/JNEUROSCI.17-19-07503.1997
intvolume: ' 17'
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6573434/
month: '10'
oa: 1
oa_version: Published Version
page: 7503 - 7522
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '4317'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential presynaptic localization of metabotropic glutamate receptor subtypes
in the rat hippocampus
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '3482'
abstract:
- lang: eng
text: AMPA- and NMDA-type glutamate receptors (AMPARs and NMDARs) mediate excitatory
synoptic transmission in the basal ganglia and may contribute to excitotoxic injury.
We investigated the functional properties of AMPARs and NMDARs expressed by six
main types of basal ganglia neurons in acute rat brain slices (principal neurons
and cholinergic interneurons of striatum, GABAergic and dopaminergic neurons of
substantia nigra, globus pallidus neurons, and subthalamic nucleus neurons) using
fast application of glutamate to nucleated and outside-out membrane patches, AMPARs
in different types of basal ganglia neurons were functionally distinct. Those
expressed in striatal principal neurons exhibited the slowest gating (desensitization
time constant τ = 11.5 msec, 1 mM glutamate, 22°C), whereas those in striatal
cholinergic interneurons showed the fastest gating (desensitization time constant
τ = 3.6 msec). The lowest Ca2+ permeability of AMPARs was observed in nigral dopaminergic
neurons (P(CA)/P(NA) = 0.10), whereas the highest Ca2+ permeability was found
in subthalamic nucleus neurons (P(Ca)/P(Na) = 1.17). NMDARs of different types
of basal ganglia neurons were less variable in their functional properties; those
expressed in nigral dopaminergic neurons exhibited the slowest gating (deactivation
time constant of predominant fast component τ1 150 msec, 100 μM glutamate), and
those of globus pallidus neurons showed the fastest gating (τ1 = 67 msec). The
Mg2+ block of NMDARs was similar; the average chord conductance ratio g(+60mv)/g(+40mV)
was 0.18-0.22 in 100 μM external Mg2+. Hence, AMPARs expressed in different types
of basal ganglia neurons are markedly diverse, whereas NMDARs are less variable
in functional properties that are relevant for excitatory synoptic transmission
and neuronal vulnerability.
acknowledgement: "This work was supported by Deutsche Forschungsgemeinschaft Grant
BE1859 to T.B. and SFB505/C5 to P.J. We thank Mrs. B. Plessow-Freudenberg for help
with the immunocytochemistry, Dr. M. Ha¨usser for advice concerning the \r\n reparation
of midbrain slices, and Drs. J. Bischofberger, G. B. Landwehrmeyer, and M. Martina
for critically reading this manuscript."
article_processing_charge: No
article_type: original
author:
- first_name: Thomas
full_name: Götz, Thomas
last_name: Götz
- first_name: Udo
full_name: Kraushaar, Udo
last_name: Kraushaar
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Joachim
full_name: Lubke, Joachim
last_name: Lubke
- first_name: Thomas
full_name: Berger, Thomas
last_name: Berger
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Götz T, Kraushaar U, Geiger J, Lubke J, Berger T, Jonas PM. Functional properties
of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons.
Journal of Neuroscience. 1997;17(1):204-215. doi:10.1523/JNEUROSCI.17-01-00204.1997
apa: Götz, T., Kraushaar, U., Geiger, J., Lubke, J., Berger, T., & Jonas, P.
M. (1997). Functional properties of AMPA and NMDA receptors expressed in identified
types of basal ganglia neurons. Journal of Neuroscience. Society for Neuroscience.
https://doi.org/10.1523/JNEUROSCI.17-01-00204.1997
chicago: Götz, Thomas, Udo Kraushaar, Jörg Geiger, Joachim Lubke, Thomas Berger,
and Peter M Jonas. “Functional Properties of AMPA and NMDA Receptors Expressed
in Identified Types of Basal Ganglia Neurons.” Journal of Neuroscience.
Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-01-00204.1997.
ieee: T. Götz, U. Kraushaar, J. Geiger, J. Lubke, T. Berger, and P. M. Jonas, “Functional
properties of AMPA and NMDA receptors expressed in identified types of basal ganglia
neurons,” Journal of Neuroscience, vol. 17, no. 1. Society for Neuroscience,
pp. 204–215, 1997.
ista: Götz T, Kraushaar U, Geiger J, Lubke J, Berger T, Jonas PM. 1997. Functional
properties of AMPA and NMDA receptors expressed in identified types of basal ganglia
neurons. Journal of Neuroscience. 17(1), 204–215.
mla: Götz, Thomas, et al. “Functional Properties of AMPA and NMDA Receptors Expressed
in Identified Types of Basal Ganglia Neurons.” Journal of Neuroscience,
vol. 17, no. 1, Society for Neuroscience, 1997, pp. 204–15, doi:10.1523/JNEUROSCI.17-01-00204.1997.
short: T. Götz, U. Kraushaar, J. Geiger, J. Lubke, T. Berger, P.M. Jonas, Journal
of Neuroscience 17 (1997) 204–215.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-01-01T00:00:00Z
date_updated: 2022-08-22T08:48:45Z
day: '01'
doi: 10.1523/JNEUROSCI.17-01-00204.1997
extern: '1'
external_id:
pmid:
- '8987749'
fulldoi: https://doi.org/10.1523/JNEUROSCI.17-01-00204.1997
intvolume: ' 17'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793708/
month: '01'
oa: 1
oa_version: Published Version
page: 204 - 215
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2905'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Functional properties of AMPA and NMDA receptors expressed in identified types
of basal ganglia neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...
---
_id: '3483'
abstract:
- lang: eng
text: 'The main excitatory pathway of the hippocampal formation is controlled by
a network of morphologically distinct populations of GABAergic interneurons. Here
we describe a novel type of GABAergic interneuron located in the outer molecular
layer (OML) of the rat dentate gyrus with a long- range forward projection from
the dentate gyrus to the subiculum across the hippocampal fissure, OML interneurons
were recorded in hippocampal slices by using the whole-cell patch-clamp configuration.
During recording, cells were filled with biocytin for subsequent light and electron
microscopic analysis. Neurons projecting to the subiculum were distributed throughout
the entire OML. They had round or ovoid somata and a multipolar dendritic morphology.
Two axonal domains could be distinguished: an extensive, tangential distribution
within the OML and a long-range vertical and tangential projection to layer 1
and stratum pyramidale of the subiculum. Symmetric synaptic contacts were established
by these interneurons on dendritic shafts in the OML and subiculum. OML interneurons
were characterized physiologically by short action potential duration and marked
afterhyperpolarization that followed the spike. On sustained current injection,
they generated high- frequency (up to 130 Hz, 34°C) trains of action potentials
with only little adaptation. In situ hybridization and single-call RT-PCR analysis
for GAD67 mRNA confirmed the GABAergic nature of OML interneurons. GABAergic interneurons
in the OML projecting to the subiculum connect the input and output regions of
the hippocampus. Hence, they could mediate long-range feed- forward inhibition
and may participate in an oscillating cross-regional interneuron network that
may synchronize the activity of spatially distributed principal neurons in the
dentate gyrus and the subiculum.'
acknowledgement: This work was supported by the Deutsche Forschungsgemeinschaft (SFB
505/A3 and Leibniz program to M.F., SFB 505/C5 to P.J., and DFG 432/3 to H.M.) We
thank Drs. H. Scharfman, M. Häusser, and I. Vida for critically reading an earlier
version of this manuscript. We are also grateful to B. Joch, S. Nestel, M. Winter,
and U. Amtmann for excellent technical assistance.
article_processing_charge: No
article_type: original
author:
- first_name: Katya
full_name: Ceranik, Katya
last_name: Ceranik
- first_name: Roland
full_name: Bender, Roland
last_name: Bender
- first_name: Jörg
full_name: Geiger, Jörg
last_name: Geiger
- first_name: Hannah
full_name: Monyer, Hannah
last_name: Monyer
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Joachim
full_name: Lubke, Joachim
last_name: Lubke
citation:
ama: Ceranik K, Bender R, Geiger J, et al. A novel type of GABAergic interneuron
connecting the input and the output regions of the hippocampus. Journal of
Neuroscience. 1997;17(14):5380-5394. doi:10.1523/JNEUROSCI.17-14-05380.1997
apa: Ceranik, K., Bender, R., Geiger, J., Monyer, H., Jonas, P. M., Frotscher, M.,
& Lubke, J. (1997). A novel type of GABAergic interneuron connecting the input
and the output regions of the hippocampus. Journal of Neuroscience. Society
for Neuroscience. https://doi.org/10.1523/JNEUROSCI.17-14-05380.1997
chicago: Ceranik, Katya, Roland Bender, Jörg Geiger, Hannah Monyer, Peter M Jonas,
Michael Frotscher, and Joachim Lubke. “A Novel Type of GABAergic Interneuron Connecting
the Input and the Output Regions of the Hippocampus.” Journal of Neuroscience.
Society for Neuroscience, 1997. https://doi.org/10.1523/JNEUROSCI.17-14-05380.1997.
ieee: K. Ceranik et al., “A novel type of GABAergic interneuron connecting
the input and the output regions of the hippocampus.,” Journal of Neuroscience,
vol. 17, no. 14. Society for Neuroscience, pp. 5380–5394, 1997.
ista: Ceranik K, Bender R, Geiger J, Monyer H, Jonas PM, Frotscher M, Lubke J. 1997.
A novel type of GABAergic interneuron connecting the input and the output regions
of the hippocampus. Journal of Neuroscience. 17(14), 5380–5394.
mla: Ceranik, Katya, et al. “A Novel Type of GABAergic Interneuron Connecting the
Input and the Output Regions of the Hippocampus.” Journal of Neuroscience,
vol. 17, no. 14, Society for Neuroscience, 1997, pp. 5380–94, doi:10.1523/JNEUROSCI.17-14-05380.1997.
short: K. Ceranik, R. Bender, J. Geiger, H. Monyer, P.M. Jonas, M. Frotscher, J.
Lubke, Journal of Neuroscience 17 (1997) 5380–5394.
date_created: 2018-12-11T12:03:34Z
date_published: 1997-07-15T00:00:00Z
date_updated: 2022-08-22T08:18:54Z
day: '15'
doi: 10.1523/JNEUROSCI.17-14-05380.1997
extern: '1'
external_id:
pmid:
- '9204922'
fulldoi: https://doi.org/10.1523/JNEUROSCI.17-14-05380.1997
intvolume: ' 17'
issue: '14'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6793821/
month: '07'
oa: 1
oa_version: Published Version
page: 5380 - 5394
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
issn:
- 0270-6474
publication_status: published
publisher: Society for Neuroscience
publist_id: '2904'
quality_controlled: '1'
scopus_import: '1'
status: public
title: A novel type of GABAergic interneuron connecting the input and the output regions
of the hippocampus.
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 17
year: '1997'
...