---
OA_type: closed access
_id: '2630'
abstract:
- lang: eng
  text: Taste-metabotropic glutamate receptor 4 (taste-mGluR4) and the heteromers
    of T1R1 and T1R3 are candidate receptors involved in the sense of umami (monosodium
    glutamate) taste. Although the expression of group III mGluRs (taste-mGluR4) has
    been demonstrated in taste tissues, no mention has been made of the expression
    of group I mGluRs (mGluR1 and mGluR5) in taste tissues. We examined the expression
    of mGluR1 and mGluR5 in rat gustatory tissues by using reverse transcription-polymerase
    chain reaction (RT-PCR), in situ hybridization, immunohistochemistry and immunoelectron
    microscopy. RT-PCR assay showed that mGluR1α and mGluR1β mRNAs were expressed
    in circumvallate papillae, but mGluR5 mRNA was not expressed. The positive signals
    of mGluR1 mRNA were detected only in circumvallate taste buds by in situ hybridization
    analysis. In cryosections of fungiform, foliate and circumvallate papillae, the
    antibody against mGluRla gave intense labeling on the taste hairs in all taste
    pores examined. In the developing taste buds, the positive signals of mGluR1α
    in taste hairs gradually increased with the increase in number of taste bud cells.
    These results show that, in addition to taste-mGluR4 and the heteromer of T1R1
    and T1R3, mGluR1α may function as a receptor for glutamate (umami) taste sensation.
article_processing_charge: No
article_type: original
author:
- first_name: Takashi
  full_name: Toyono, Takashi
  last_name: Toyono
- first_name: Yuji
  full_name: Seta, Yuji
  last_name: Seta
- first_name: Shinji
  full_name: Kataoka, Shinji
  last_name: Kataoka
- first_name: Shintaro
  full_name: Kawano, Shintaro
  last_name: Kawano
- first_name: Ryuichi
  full_name: Shigemoto, Ryuichi
  id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
  last_name: Shigemoto
  orcid: 0000-0001-8761-9444
- first_name: Kuniaki
  full_name: Toyoshima, Kuniaki
  last_name: Toyoshima
citation:
  ama: Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. Expression
    of metabotropic glutamate receptor group I in rat gustatory papillae. <i>Cell
    and Tissue Research</i>. 2003;313:29-35. doi:<a href="https://doi.org/10.1007/s00441-003-0740-2">10.1007/s00441-003-0740-2</a>
  apa: Toyono, T., Seta, Y., Kataoka, S., Kawano, S., Shigemoto, R., &#38; Toyoshima,
    K. (2003). Expression of metabotropic glutamate receptor group I in rat gustatory
    papillae. <i>Cell and Tissue Research</i>. Springer Nature. <a href="https://doi.org/10.1007/s00441-003-0740-2">https://doi.org/10.1007/s00441-003-0740-2</a>
  chicago: Toyono, Takashi, Yuji Seta, Shinji Kataoka, Shintaro Kawano, Ryuichi Shigemoto,
    and Kuniaki Toyoshima. “Expression of Metabotropic Glutamate Receptor Group I
    in Rat Gustatory Papillae.” <i>Cell and Tissue Research</i>. Springer Nature,
    2003. <a href="https://doi.org/10.1007/s00441-003-0740-2">https://doi.org/10.1007/s00441-003-0740-2</a>.
  ieee: T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, and K. Toyoshima,
    “Expression of metabotropic glutamate receptor group I in rat gustatory papillae,”
    <i>Cell and Tissue Research</i>, vol. 313. Springer Nature, pp. 29–35, 2003.
  ista: Toyono T, Seta Y, Kataoka S, Kawano S, Shigemoto R, Toyoshima K. 2003. Expression
    of metabotropic glutamate receptor group I in rat gustatory papillae. Cell and
    Tissue Research. 313, 29–35.
  mla: Toyono, Takashi, et al. “Expression of Metabotropic Glutamate Receptor Group
    I in Rat Gustatory Papillae.” <i>Cell and Tissue Research</i>, vol. 313, Springer
    Nature, 2003, pp. 29–35, doi:<a href="https://doi.org/10.1007/s00441-003-0740-2">10.1007/s00441-003-0740-2</a>.
  short: T. Toyono, Y. Seta, S. Kataoka, S. Kawano, R. Shigemoto, K. Toyoshima, Cell
    and Tissue Research 313 (2003) 29–35.
date_created: 2018-12-11T11:58:46Z
date_published: 2003-07-01T00:00:00Z
date_updated: 2026-05-22T10:51:39Z
day: '01'
doi: 10.1007/s00441-003-0740-2
extern: '1'
external_id:
  pmid:
  - '12898387'
intvolume: '       313'
language:
- iso: eng
month: '07'
oa_version: None
page: 29 - 35
pmid: 1
publication: Cell and Tissue Research
publication_identifier:
  eissn:
  - 1432-0878
  issn:
  - 0302-766X
publication_status: published
publisher: Springer Nature
publist_id: '4267'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Expression of metabotropic glutamate receptor group I in rat gustatory papillae
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 313
year: '2003'
...