---
OA_place: repository
OA_type: green
_id: '3744'
abstract:
- lang: eng
  text: It is widely acknowledged that detailed timing of action potentials is used
    to encode information, for example, in auditory pathways; however, the computational
    tools required to analyze encoding through timing are still in their infancy.
    We present a simple example of encoding, based on a recent model of time-frequency
    analysis, in which units fire action potentials when a certain condition is met,
    but the timing of the action potential depends also on other features of the stimulus.
    We show that, as a result, spike-triggered averages are smoothed so much that
    they do not represent the true features of the encoding. Inspired by this example,
    we present a simple method, differential reverse correlations, that can separate
    an analysis of what causes a neuron to spike, and what controls its timing. We
    analyze with this method the leaky integrate-and-fire neuron and show the method
    accurately reconstructs the model's kernel.
article_processing_charge: No
article_type: original
author:
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
- first_name: Marcelo
  full_name: Magnasco, Marcelo
  last_name: Magnasco
citation:
  ama: 'Tkačik G, Magnasco M. Decoding spike timing: The differential reverse-correlation
    method. <i>Biosystems</i>. 2008;93(1-2):90-100. doi:<a href="https://doi.org/10.1016/j.biosystems.2008.04.011">10.1016/j.biosystems.2008.04.011</a>'
  apa: 'Tkačik, G., &#38; Magnasco, M. (2008). Decoding spike timing: The differential
    reverse-correlation method. <i>Biosystems</i>. Elsevier. <a href="https://doi.org/10.1016/j.biosystems.2008.04.011">https://doi.org/10.1016/j.biosystems.2008.04.011</a>'
  chicago: 'Tkačik, Gašper, and Marcelo Magnasco. “Decoding Spike Timing: The Differential
    Reverse-Correlation Method.” <i>Biosystems</i>. Elsevier, 2008. <a href="https://doi.org/10.1016/j.biosystems.2008.04.011">https://doi.org/10.1016/j.biosystems.2008.04.011</a>.'
  ieee: 'G. Tkačik and M. Magnasco, “Decoding spike timing: The differential reverse-correlation
    method,” <i>Biosystems</i>, vol. 93, no. 1–2. Elsevier, pp. 90–100, 2008.'
  ista: 'Tkačik G, Magnasco M. 2008. Decoding spike timing: The differential reverse-correlation
    method. Biosystems. 93(1–2), 90–100.'
  mla: 'Tkačik, Gašper, and Marcelo Magnasco. “Decoding Spike Timing: The Differential
    Reverse-Correlation Method.” <i>Biosystems</i>, vol. 93, no. 1–2, Elsevier, 2008,
    pp. 90–100, doi:<a href="https://doi.org/10.1016/j.biosystems.2008.04.011">10.1016/j.biosystems.2008.04.011</a>.'
  short: G. Tkačik, M. Magnasco, Biosystems 93 (2008) 90–100.
date_created: 2018-12-11T12:04:56Z
date_published: 2008-07-01T00:00:00Z
date_updated: 2026-06-10T10:36:02Z
day: '01'
doi: 10.1016/j.biosystems.2008.04.011
extern: '1'
external_id:
  pmid:
  - '18597928'
intvolume: '        93'
issue: 1-2
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2792887
month: '07'
oa: 1
oa_version: None
page: 90 - 100
pmid: 1
publication: Biosystems
publication_identifier:
  eissn:
  - 1872-8324
  issn:
  - 0303-2647
publication_status: published
publisher: Elsevier
publist_id: '2482'
status: public
title: 'Decoding spike timing: The differential reverse-correlation method'
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 93
year: '2008'
...