[{"oa":1,"quality_controlled":"1","publisher":"Elsevier","acknowledgement":"We thank Liqun Luo for his continued support, for providing essential resources for generating Fzd10-CreER mice which were generated in his laboratory, and for comments on the manuscript; W. Zhong for providing Nestin-Cre transgenic mouse line for this study; A. Heger for mouse colony management; R. Beattie and T. Asenov for designing and producing components of acute slice recovery chamber for MADM-CloneSeq experiments; and K. Leopold, J. Rodarte and N. Amberg for initial experiments, technical support and/or assistance. This study was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging & Optics Facility (IOF), Laboratory Support Facility (LSF), Miba Machine Shop, and Pre-clinical Facility (PCF). G.C. received funding from European Commission (IST plus postdoctoral fellowship). This work was supported by ISTA institutional\r\nfunds; the Austrian Science Fund Special Research Programmes (FWF SFB F78 Neuro Stem Modulation) to S.H. ","date_created":"2023-04-27T09:41:48Z","date_published":"2024-01-17T00:00:00Z","doi":"10.1016/j.neuron.2023.11.009","page":"230-246.e11","publication":"Neuron","day":"17","year":"2024","has_accepted_license":"1","project":[{"grant_number":"F07805","name":"Molecular Mechanisms of Neural Stem Cell Lineage Progression","_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E"}],"title":"Multipotent progenitors instruct ontogeny of the superior colliculus","article_processing_charge":"Yes (via OA deal)","external_id":{"pmid":["38096816"]},"author":[{"id":"471195F6-F248-11E8-B48F-1D18A9856A87","first_name":"Giselle T","full_name":"Cheung, Giselle T","orcid":"0000-0001-8457-2572","last_name":"Cheung"},{"id":"48EA0138-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","full_name":"Pauler, Florian","orcid":"0000-0002-7462-0048","last_name":"Pauler"},{"last_name":"Koppensteiner","orcid":"0000-0002-3509-1948","full_name":"Koppensteiner, Peter","first_name":"Peter","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Thomas","full_name":"Krausgruber, Thomas","last_name":"Krausgruber"},{"last_name":"Streicher","full_name":"Streicher, Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","first_name":"Carmen"},{"first_name":"Martin","id":"f13e7cae-e8bd-11ed-841a-96dedf69f46d","full_name":"Schrammel, Martin","last_name":"Schrammel"},{"first_name":"Natalie Y","id":"e68ece33-f6e0-11ea-865d-ae1031dcc090","last_name":"Özgen","full_name":"Özgen, Natalie Y"},{"full_name":"Ivec, Alexis","last_name":"Ivec","id":"1d144691-e8be-11ed-9b33-bdd3077fad4c","first_name":"Alexis"},{"last_name":"Bock","full_name":"Bock, Christoph","first_name":"Christoph"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","last_name":"Hippenmeyer","first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Cheung, Giselle T, Florian Pauler, Peter Koppensteiner, Thomas Krausgruber, Carmen Streicher, Martin Schrammel, Natalie Y Özgen, et al. “Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.” Neuron. Elsevier, 2024. https://doi.org/10.1016/j.neuron.2023.11.009.","ista":"Cheung GT, Pauler F, Koppensteiner P, Krausgruber T, Streicher C, Schrammel M, Özgen NY, Ivec A, Bock C, Shigemoto R, Hippenmeyer S. 2024. Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. 112(2), 230–246.e11.","mla":"Cheung, Giselle T., et al. “Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.” Neuron, vol. 112, no. 2, Elsevier, 2024, p. 230–246.e11, doi:10.1016/j.neuron.2023.11.009.","ieee":"G. T. Cheung et al., “Multipotent progenitors instruct ontogeny of the superior colliculus,” Neuron, vol. 112, no. 2. Elsevier, p. 230–246.e11, 2024.","short":"G.T. Cheung, F. Pauler, P. Koppensteiner, T. Krausgruber, C. Streicher, M. Schrammel, N.Y. Özgen, A. Ivec, C. Bock, R. Shigemoto, S. Hippenmeyer, Neuron 112 (2024) 230–246.e11.","apa":"Cheung, G. T., Pauler, F., Koppensteiner, P., Krausgruber, T., Streicher, C., Schrammel, M., … Hippenmeyer, S. (2024). Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2023.11.009","ama":"Cheung GT, Pauler F, Koppensteiner P, et al. Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. 2024;112(2):230-246.e11. doi:10.1016/j.neuron.2023.11.009"},"intvolume":" 112","month":"01","scopus_import":"1","oa_version":"Published Version","pmid":1,"abstract":[{"text":"The superior colliculus (SC) in the mammalian midbrain is essential for multisensory integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia. However, the developmental principles directing the generation of SC cell-type diversity are not understood. Here, we pursued systematic cell lineage tracing in silico and in vivo, preserving full spatial information, using genetic mosaic analysis with double markers (MADM)-based clonal analysis with single-cell sequencing (MADM-CloneSeq). The analysis of clonally related cell lineages revealed that radial glial progenitors (RGPs) in SC are exceptionally multipotent. Individual resident RGPs have the capacity to produce all excitatory and inhibitory SC neuron types, even at the stage of terminal division. While individual clonal units show no pre-defined cellular composition, the establishment of appropriate relative proportions of distinct neuronal types occurs in a PTEN-dependent manner. Collectively, our findings provide an inaugural framework at the single-RGP/-cell level of the mammalian SC ontogeny.","lang":"eng"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"},{"_id":"LifeSc"},{"_id":"PreCl"}],"license":"https://creativecommons.org/licenses/by/4.0/","volume":112,"related_material":{"link":[{"url":"https://ista.ac.at/en/news/the-pedigree-of-brain-cells/","relation":"press_release","description":"News on ISTA Website"}]},"issue":"2","language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_id":"14944","checksum":"32b3788f7085cf44a84108d8faaff3ce","success":1,"date_updated":"2024-02-06T13:56:15Z","file_size":5942467,"creator":"dernst","date_created":"2024-02-06T13:56:15Z","file_name":"2024_Neuron_Cheung.pdf"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","type":"journal_article","_id":"12875","department":[{"_id":"SiHi"},{"_id":"RySh"}],"file_date_updated":"2024-02-06T13:56:15Z","ddc":["570"],"date_updated":"2024-03-05T09:43:02Z"},{"month":"01","scopus_import":"1","pmid":1,"oa_version":"None","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"PreCl"},{"_id":"M-Shop"}],"abstract":[{"lang":"eng","text":"The coupling between Ca2+ channels and release sensors is a key factor defining the signaling properties of a synapse. However, the coupling nanotopography at many synapses remains unknown, and it is unclear how it changes during development. To address these questions, we examined coupling at the cerebellar inhibitory basket cell (BC)-Purkinje cell (PC) synapse. Biophysical analysis of transmission by paired recording and intracellular pipette perfusion revealed that the effects of exogenous Ca2+ chelators decreased during development, despite constant reliance of release on P/Q-type Ca2+ channels. Structural analysis by freeze-fracture replica labeling (FRL) and transmission electron microscopy (EM) indicated that presynaptic P/Q-type Ca2+ channels formed nanoclusters throughout development, whereas docked vesicles were only clustered at later developmental stages. Modeling suggested a developmental transformation from a more random to a more clustered coupling nanotopography. Thus, presynaptic signaling developmentally approaches a point-to-point configuration, optimizing speed, reliability, and energy efficiency of synaptic transmission."}],"ec_funded":1,"related_material":{"link":[{"description":"News on ISTA Website","url":"https://ista.ac.at/en/news/synapses-brought-to-the-point/","relation":"press_release"}],"record":[{"relation":"dissertation_contains","status":"public","id":"15101"}]},"language":[{"iso":"eng"}],"publication_status":"inpress","publication_identifier":{"issn":["0896-6273"],"eissn":["1097-4199"]},"status":"public","article_type":"original","type":"journal_article","_id":"14843","department":[{"_id":"PeJo"},{"_id":"EM-Fac"},{"_id":"RySh"}],"date_updated":"2024-03-14T13:14:18Z","quality_controlled":"1","publisher":"Elsevier","acknowledgement":"We thank Drs. David DiGregorio and Erwin Neher for critically reading an earlier version of the manuscript, Ralf Schneggenburger for helpful discussions, Benjamin Suter and Katharina Lichter for support with image analysis, Chris Wojtan for advice on numerical solution of partial differential equations, Maria Reva for help with Ripley analysis, Alois Schlögl for programming, and Akari Hagiwara and Toshihisa Ohtsuka for anti-ELKS antibody. We are grateful to Florian Marr, Christina Altmutter, and Vanessa Zheden for excellent technical assistance and to Eleftheria Kralli-Beller for manuscript editing. This research was supported by the Scientific Services Units (SSUs) of ISTA (Electron Microscopy Facility, Preclinical Facility, and Machine Shop). The project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 692692), the Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award; P 36232-B), all to P.J., and a DOC fellowship of the Austrian Academy of Sciences to J.-J.C.","date_created":"2024-01-21T23:00:56Z","doi":"10.1016/j.neuron.2023.12.002","date_published":"2024-01-11T00:00:00Z","publication":"Neuron","day":"11","year":"2024","project":[{"grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glumatergic synapse","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"call_identifier":"FWF","_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312","name":"The Wittgenstein Prize"},{"_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5","grant_number":"P36232","name":"Mechanisms of GABA release in hippocampal circuits"},{"name":"Development of nanodomain coupling between Ca2+ channels and release sensors at a central inhibitory synapse","grant_number":"25383","_id":"26B66A3E-B435-11E9-9278-68D0E5697425"}],"title":"Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse","external_id":{"pmid":["38215739"]},"article_processing_charge":"No","author":[{"full_name":"Chen, JingJing","last_name":"Chen","id":"2C4E65C8-F248-11E8-B48F-1D18A9856A87","first_name":"JingJing"},{"id":"3F99E422-F248-11E8-B48F-1D18A9856A87","first_name":"Walter","last_name":"Kaufmann","orcid":"0000-0001-9735-5315","full_name":"Kaufmann, Walter"},{"last_name":"Chen","full_name":"Chen, Chong","id":"3DFD581A-F248-11E8-B48F-1D18A9856A87","first_name":"Chong"},{"id":"32A73F6C-F248-11E8-B48F-1D18A9856A87","first_name":"Itaru","full_name":"Arai, Itaru","last_name":"Arai"},{"first_name":"Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87","full_name":"Kim, Olena","last_name":"Kim"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Chen, JingJing, Walter Kaufmann, Chong Chen, itaru Arai, Olena Kim, Ryuichi Shigemoto, and Peter M Jonas. “Developmental Transformation of Ca2+ Channel-Vesicle Nanotopography at a Central GABAergic Synapse.” Neuron. Elsevier, n.d. https://doi.org/10.1016/j.neuron.2023.12.002.","ista":"Chen J, Kaufmann W, Chen C, Arai itaru, Kim O, Shigemoto R, Jonas PM. Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron.","mla":"Chen, JingJing, et al. “Developmental Transformation of Ca2+ Channel-Vesicle Nanotopography at a Central GABAergic Synapse.” Neuron, Elsevier, doi:10.1016/j.neuron.2023.12.002.","ieee":"J. Chen et al., “Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse,” Neuron. Elsevier.","short":"J. Chen, W. Kaufmann, C. Chen, itaru Arai, O. Kim, R. Shigemoto, P.M. Jonas, Neuron (n.d.).","ama":"Chen J, Kaufmann W, Chen C, et al. Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron. doi:10.1016/j.neuron.2023.12.002","apa":"Chen, J., Kaufmann, W., Chen, C., Arai, itaru, Kim, O., Shigemoto, R., & Jonas, P. M. (n.d.). Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2023.12.002"}},{"_id":"9793","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-09-27T07:46:09Z","department":[{"_id":"SiHi"}],"abstract":[{"lang":"eng","text":"Astrocytes extensively infiltrate the neuropil to regulate critical aspects of synaptic development and function. This process is regulated by transcellular interactions between astrocytes and neurons via cell adhesion molecules. How astrocytes coordinate developmental processes among one another to parse out the synaptic neuropil and form non-overlapping territories is unknown. Here we identify a molecular mechanism regulating astrocyte-astrocyte interactions during development to coordinate astrocyte morphogenesis and gap junction coupling. We show that hepaCAM, a disease-linked, astrocyte-enriched cell adhesion molecule, regulates astrocyte competition for territory and morphological complexity in the developing mouse cortex. Furthermore, conditional deletion of Hepacam from developing astrocytes significantly impairs gap junction coupling between astrocytes and disrupts the balance between synaptic excitation and inhibition. Mutations in HEPACAM cause megalencephalic leukoencephalopathy with subcortical cysts in humans. Therefore, our findings suggest that disruption of astrocyte self-organization mechanisms could be an underlying cause of neural pathology."}],"oa_version":"Published Version","pmid":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2021.05.025"}],"scopus_import":"1","intvolume":" 109","month":"08","publication_status":"published","publication_identifier":{"issn":["0896-6273"],"eissn":["1097-4199"]},"language":[{"iso":"eng"}],"ec_funded":1,"issue":"15","volume":109,"project":[{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780","_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"citation":{"ista":"Baldwin KT, Tan CX, Strader ST, Jiang C, Savage JT, Elorza-Vidal X, Contreras X, Rülicke T, Hippenmeyer S, Estévez R, Ji R-R, Eroglu C. 2021. HepaCAM controls astrocyte self-organization and coupling. Neuron. 109(15), 2427–2442.e10.","chicago":"Baldwin, Katherine T., Christabel X. Tan, Samuel T. Strader, Changyu Jiang, Justin T. Savage, Xabier Elorza-Vidal, Ximena Contreras, et al. “HepaCAM Controls Astrocyte Self-Organization and Coupling.” Neuron. Elsevier, 2021. https://doi.org/10.1016/j.neuron.2021.05.025.","short":"K.T. Baldwin, C.X. Tan, S.T. Strader, C. Jiang, J.T. Savage, X. Elorza-Vidal, X. Contreras, T. Rülicke, S. Hippenmeyer, R. Estévez, R.-R. Ji, C. Eroglu, Neuron 109 (2021) 2427–2442.e10.","ieee":"K. T. Baldwin et al., “HepaCAM controls astrocyte self-organization and coupling,” Neuron, vol. 109, no. 15. Elsevier, p. 2427–2442.e10, 2021.","apa":"Baldwin, K. T., Tan, C. X., Strader, S. T., Jiang, C., Savage, J. T., Elorza-Vidal, X., … Eroglu, C. (2021). HepaCAM controls astrocyte self-organization and coupling. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2021.05.025","ama":"Baldwin KT, Tan CX, Strader ST, et al. HepaCAM controls astrocyte self-organization and coupling. Neuron. 2021;109(15):2427-2442.e10. doi:10.1016/j.neuron.2021.05.025","mla":"Baldwin, Katherine T., et al. “HepaCAM Controls Astrocyte Self-Organization and Coupling.” Neuron, vol. 109, no. 15, Elsevier, 2021, p. 2427–2442.e10, doi:10.1016/j.neuron.2021.05.025."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["34171291"],"isi":["000692851900010"]},"article_processing_charge":"No","author":[{"last_name":"Baldwin","full_name":"Baldwin, Katherine T.","first_name":"Katherine T."},{"first_name":"Christabel X.","full_name":"Tan, Christabel X.","last_name":"Tan"},{"last_name":"Strader","full_name":"Strader, Samuel T.","first_name":"Samuel T."},{"first_name":"Changyu","last_name":"Jiang","full_name":"Jiang, Changyu"},{"last_name":"Savage","full_name":"Savage, Justin T.","first_name":"Justin T."},{"first_name":"Xabier","full_name":"Elorza-Vidal, Xabier","last_name":"Elorza-Vidal"},{"last_name":"Contreras","full_name":"Contreras, Ximena","first_name":"Ximena","id":"475990FE-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Thomas","last_name":"Rülicke","full_name":"Rülicke, Thomas"},{"last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon"},{"first_name":"Raúl","last_name":"Estévez","full_name":"Estévez, Raúl"},{"last_name":"Ji","full_name":"Ji, Ru-Rong","first_name":"Ru-Rong"},{"first_name":"Cagla","last_name":"Eroglu","full_name":"Eroglu, Cagla"}],"title":"HepaCAM controls astrocyte self-organization and coupling","acknowledgement":"This work was supported by the National Institutes of Health (R01 DA047258 and R01 NS102237 to C.E., F32 NS100392 to K.T.B.) and the Holland-Trice Brain Research Award (to C.E.). K.T.B. was supported by postdoctoral fellowships from the Foerster-Bernstein Family and The Hartwell Foundation. The Hippenmeyer lab was supported by the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovations program (725780 LinPro) to S.H. R.E. was supported by Ministerio de Ciencia y Tecnología (RTI2018-093493-B-I00). We thank the Duke Light Microscopy Core Facility, the Duke Transgenic Mouse Facility, Dr. U. Schulte for assistance with proteomic experiments, and Dr. D. Silver for critical review of the manuscript. Cartoon elements of figure panels were created using BioRender.com.","oa":1,"quality_controlled":"1","publisher":"Elsevier","year":"2021","isi":1,"publication":"Neuron","day":"04","page":"2427-2442.e10","date_created":"2021-08-06T09:08:25Z","date_published":"2021-08-04T00:00:00Z","doi":"10.1016/j.neuron.2021.05.025"},{"_id":"11054","keyword":["General Neuroscience"],"status":"public","article_type":"review","type":"journal_article","extern":"1","date_updated":"2022-07-18T08:29:35Z","pmid":1,"oa_version":"Published Version","abstract":[{"text":"In recent years, the nuclear pore complex (NPC) has emerged as a key player in genome regulation and cellular homeostasis. New discoveries have revealed that the NPC has multiple cellular functions besides mediating the molecular exchange between the nucleus and the cytoplasm. In this review, we discuss non-transport aspects of the NPC focusing on the NPC-genome interaction, the extreme longevity of the NPC proteins, and NPC dysfunction in age-related diseases. The examples summarized herein demonstrate that the NPC, which first evolved to enable the biochemical communication between the nucleus and the cytoplasm, now doubles as the gatekeeper of cellular identity and aging.","lang":"eng"}],"intvolume":" 106","month":"06","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2020.05.031"}],"scopus_import":"1","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"volume":106,"issue":"6","user_id":"72615eeb-f1f3-11ec-aa25-d4573ddc34fd","citation":{"mla":"Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” Neuron, vol. 106, no. 6, Elsevier, 2020, pp. 899–911, doi:10.1016/j.neuron.2020.05.031.","short":"U.H. Cho, M. Hetzer, Neuron 106 (2020) 899–911.","ieee":"U. H. Cho and M. Hetzer, “Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging,” Neuron, vol. 106, no. 6. Elsevier, pp. 899–911, 2020.","ama":"Cho UH, Hetzer M. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 2020;106(6):899-911. doi:10.1016/j.neuron.2020.05.031","apa":"Cho, U. H., & Hetzer, M. (2020). Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.05.031","chicago":"Cho, Ukrae H., and Martin Hetzer. “Nuclear Periphery Takes Center Stage: The Role of Nuclear Pore Complexes in Cell Identity and Aging.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.05.031.","ista":"Cho UH, Hetzer M. 2020. Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging. Neuron. 106(6), 899–911."},"title":"Nuclear periphery takes center stage: The role of nuclear pore complexes in cell identity and aging","article_processing_charge":"No","external_id":{"pmid":["32553207"]},"author":[{"first_name":"Ukrae H.","last_name":"Cho","full_name":"Cho, Ukrae H."},{"id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","first_name":"Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W"}],"oa":1,"publisher":"Elsevier","quality_controlled":"1","publication":"Neuron","day":"17","year":"2020","date_created":"2022-04-07T07:43:36Z","doi":"10.1016/j.neuron.2020.05.031","date_published":"2020-06-17T00:00:00Z","page":"899-911"},{"date_created":"2020-02-10T15:45:48Z","date_published":"2020-04-08T00:00:00Z","doi":"10.1016/j.neuron.2020.01.015","page":"P154-165.e6","publication":"Neuron","day":"08","year":"2020","isi":1,"oa":1,"quality_controlled":"1","publisher":"Elsevier","acknowledgement":"We thank Todor Asenov and Thomas Menner from the Machine Shop for the drive design and production, Hugo Malagon-Vina for assistance in maze automatization, Jago Wallenschus for taking the images of the histology, and Federico Stella and Juan Felipe Ramirez-Villegas for comments on an earlier version of the manuscript. This work was supported by the EU-FP7 MC-ITN IN-SENS (grant 607616 ).","title":"Replay of behavioral sequences in the medial prefrontal cortex during rule switching","article_processing_charge":"No","external_id":{"isi":["000525319300016"],"pmid":["32032512"]},"author":[{"first_name":"Karola","id":"2DAA49AA-F248-11E8-B48F-1D18A9856A87","full_name":"Käfer, Karola","last_name":"Käfer"},{"id":"30BD0376-F248-11E8-B48F-1D18A9856A87","first_name":"Michele","orcid":"0000-0001-8849-6570","full_name":"Nardin, Michele","last_name":"Nardin"},{"full_name":"Blahna, Karel","last_name":"Blahna","first_name":"Karel","id":"3EA859AE-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Csicsvari","orcid":"0000-0002-5193-4036","full_name":"Csicsvari, Jozsef L","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ista":"Käfer K, Nardin M, Blahna K, Csicsvari JL. 2020. Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. 106(1), P154–165.e6.","chicago":"Käfer, Karola, Michele Nardin, Karel Blahna, and Jozsef L Csicsvari. “Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.01.015.","ieee":"K. Käfer, M. Nardin, K. Blahna, and J. L. Csicsvari, “Replay of behavioral sequences in the medial prefrontal cortex during rule switching,” Neuron, vol. 106, no. 1. Elsevier, p. P154–165.e6, 2020.","short":"K. Käfer, M. Nardin, K. Blahna, J.L. Csicsvari, Neuron 106 (2020) P154–165.e6.","ama":"Käfer K, Nardin M, Blahna K, Csicsvari JL. Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. 2020;106(1):P154-165.e6. doi:10.1016/j.neuron.2020.01.015","apa":"Käfer, K., Nardin, M., Blahna, K., & Csicsvari, J. L. (2020). Replay of behavioral sequences in the medial prefrontal cortex during rule switching. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.01.015","mla":"Käfer, Karola, et al. “Replay of Behavioral Sequences in the Medial Prefrontal Cortex during Rule Switching.” Neuron, vol. 106, no. 1, Elsevier, 2020, p. P154–165.e6, doi:10.1016/j.neuron.2020.01.015."},"project":[{"grant_number":"607616","name":"Inter-and intracellular signalling in schizophrenia","call_identifier":"FP7","_id":"257BBB4C-B435-11E9-9278-68D0E5697425"}],"ec_funded":1,"volume":106,"related_material":{"link":[{"url":"https://ist.ac.at/en/news/this-brain-area-helps-us-decide/","relation":"press_release","description":"News on IST Homepage"}]},"issue":"1","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"intvolume":" 106","month":"04","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2020.01.015"}],"scopus_import":"1","pmid":1,"oa_version":"Published Version","abstract":[{"text":"Temporally organized reactivation of experiences during awake immobility periods is thought to underlie cognitive processes like planning and evaluation. While replay of trajectories is well established for the hippocampus, it is unclear whether the medial prefrontal cortex (mPFC) can reactivate sequential behavioral experiences in the awake state to support task execution. We simultaneously recorded from hippocampal and mPFC principal neurons in rats performing a mPFC-dependent rule-switching task on a plus maze. We found that mPFC neuronal activity encoded relative positions between the start and goal. During awake immobility periods, the mPFC replayed temporally organized sequences of these generalized positions, resembling entire spatial trajectories. The occurrence of mPFC trajectory replay positively correlated with rule-switching performance. However, hippocampal and mPFC trajectory replay occurred independently, indicating different functions. These results demonstrate that the mPFC can replay ordered activity patterns representing generalized locations and suggest that mPFC replay might have a role in flexible behavior.","lang":"eng"}],"acknowledged_ssus":[{"_id":"M-Shop"}],"department":[{"_id":"JoCs"}],"date_updated":"2023-08-17T14:38:02Z","status":"public","article_type":"original","type":"journal_article","_id":"7472"},{"oa":1,"quality_controlled":"1","publisher":"Cell Press","page":"106-121.e10","date_created":"2020-02-28T10:43:39Z","doi":"10.1016/j.neuron.2019.10.001","date_published":"2020-01-08T00:00:00Z","year":"2020","has_accepted_license":"1","isi":1,"publication":"Neuron","day":"08","external_id":{"pmid":["31757604"],"isi":["000507341300012"]},"article_processing_charge":"No","author":[{"first_name":"Isabel","full_name":"Beets, Isabel","last_name":"Beets"},{"first_name":"Gaotian","full_name":"Zhang, Gaotian","last_name":"Zhang"},{"first_name":"Lorenz A.","full_name":"Fenk, Lorenz A.","last_name":"Fenk"},{"first_name":"Changchun","full_name":"Chen, Changchun","last_name":"Chen"},{"first_name":"Geoffrey M.","last_name":"Nelson","full_name":"Nelson, Geoffrey M."},{"first_name":"Marie-Anne","full_name":"Félix, Marie-Anne","last_name":"Félix"},{"last_name":"de Bono","full_name":"de Bono, Mario","orcid":"0000-0001-8347-0443","first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87"}],"title":"Natural variation in a dendritic scaffold protein remodels experience-dependent plasticity by altering neuropeptide expression","citation":{"chicago":"Beets, Isabel, Gaotian Zhang, Lorenz A. Fenk, Changchun Chen, Geoffrey M. Nelson, Marie-Anne Félix, and Mario de Bono. “Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Altering Neuropeptide Expression.” Neuron. Cell Press, 2020. https://doi.org/10.1016/j.neuron.2019.10.001.","ista":"Beets I, Zhang G, Fenk LA, Chen C, Nelson GM, Félix M-A, de Bono M. 2020. Natural variation in a dendritic scaffold protein remodels experience-dependent plasticity by altering neuropeptide expression. Neuron. 105(1), 106–121.e10.","mla":"Beets, Isabel, et al. “Natural Variation in a Dendritic Scaffold Protein Remodels Experience-Dependent Plasticity by Altering Neuropeptide Expression.” Neuron, vol. 105, no. 1, Cell Press, 2020, p. 106–121.e10, doi:10.1016/j.neuron.2019.10.001.","apa":"Beets, I., Zhang, G., Fenk, L. A., Chen, C., Nelson, G. M., Félix, M.-A., & de Bono, M. (2020). Natural variation in a dendritic scaffold protein remodels experience-dependent plasticity by altering neuropeptide expression. Neuron. Cell Press. https://doi.org/10.1016/j.neuron.2019.10.001","ama":"Beets I, Zhang G, Fenk LA, et al. Natural variation in a dendritic scaffold protein remodels experience-dependent plasticity by altering neuropeptide expression. Neuron. 2020;105(1):106-121.e10. doi:10.1016/j.neuron.2019.10.001","ieee":"I. Beets et al., “Natural variation in a dendritic scaffold protein remodels experience-dependent plasticity by altering neuropeptide expression,” Neuron, vol. 105, no. 1. Cell Press, p. 106–121.e10, 2020.","short":"I. Beets, G. Zhang, L.A. Fenk, C. Chen, G.M. Nelson, M.-A. Félix, M. de Bono, Neuron 105 (2020) 106–121.e10."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":" 105","month":"01","abstract":[{"text":"The extent to which behavior is shaped by experience varies between individuals. Genetic differences contribute to this variation, but the neural mechanisms are not understood. Here, we dissect natural variation in the behavioral flexibility of two Caenorhabditis elegans wild strains. In one strain, a memory of exposure to 21% O2 suppresses CO2-evoked locomotory arousal; in the other, CO2 evokes arousal regardless of previous O2 experience. We map that variation to a polymorphic dendritic scaffold protein, ARCP-1, expressed in sensory neurons. ARCP-1 binds the Ca2+-dependent phosphodiesterase PDE-1 and co-localizes PDE-1 with molecular sensors for CO2 at dendritic ends. Reducing ARCP-1 or PDE-1 activity promotes CO2 escape by altering neuropeptide expression in the BAG CO2 sensors. Variation in ARCP-1 alters behavioral plasticity in multiple paradigms. Our findings are reminiscent of genetic accommodation, an evolutionary process by which phenotypic flexibility in response to environmental variation is reset by genetic change.","lang":"eng"}],"oa_version":"Published Version","pmid":1,"issue":"1","volume":105,"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_id":"7558","checksum":"799bfd297a008753a688b30d3958fa48","file_size":3294066,"date_updated":"2020-07-14T12:48:00Z","creator":"dernst","file_name":"2020_Neuron_Beets.pdf","date_created":"2020-03-02T15:43:57Z"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","article_type":"original","status":"public","_id":"7546","file_date_updated":"2020-07-14T12:48:00Z","department":[{"_id":"MaDe"}],"date_updated":"2023-08-18T06:46:23Z","ddc":["570"]},{"author":[{"first_name":"David H","id":"3AE48E0A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7577-1676","full_name":"Vandael, David H","last_name":"Vandael"},{"last_name":"Borges Merjane","full_name":"Borges Merjane, Carolina","orcid":"0000-0003-0005-401X","id":"4305C450-F248-11E8-B48F-1D18A9856A87","first_name":"Carolina"},{"full_name":"Zhang, Xiaomin","last_name":"Zhang","id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","first_name":"Xiaomin"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas"}],"article_processing_charge":"No","external_id":{"pmid":["32492366"],"isi":["000556135600004"]},"title":"Short-term plasticity at hippocampal mossy fiber synapses is induced by natural activity patterns and associated with vesicle pool engram formation","citation":{"mla":"Vandael, David H., et al. “Short-Term Plasticity at Hippocampal Mossy Fiber Synapses Is Induced by Natural Activity Patterns and Associated with Vesicle Pool Engram Formation.” Neuron, vol. 107, no. 3, Elsevier, 2020, pp. 509–21, doi:10.1016/j.neuron.2020.05.013.","apa":"Vandael, D. H., Borges Merjane, C., Zhang, X., & Jonas, P. M. (2020). Short-term plasticity at hippocampal mossy fiber synapses is induced by natural activity patterns and associated with vesicle pool engram formation. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.05.013","ama":"Vandael DH, Borges Merjane C, Zhang X, Jonas PM. Short-term plasticity at hippocampal mossy fiber synapses is induced by natural activity patterns and associated with vesicle pool engram formation. Neuron. 2020;107(3):509-521. doi:10.1016/j.neuron.2020.05.013","ieee":"D. H. Vandael, C. Borges Merjane, X. Zhang, and P. M. Jonas, “Short-term plasticity at hippocampal mossy fiber synapses is induced by natural activity patterns and associated with vesicle pool engram formation,” Neuron, vol. 107, no. 3. Elsevier, pp. 509–521, 2020.","short":"D.H. Vandael, C. Borges Merjane, X. Zhang, P.M. Jonas, Neuron 107 (2020) 509–521.","chicago":"Vandael, David H, Carolina Borges Merjane, Xiaomin Zhang, and Peter M Jonas. “Short-Term Plasticity at Hippocampal Mossy Fiber Synapses Is Induced by Natural Activity Patterns and Associated with Vesicle Pool Engram Formation.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.05.013.","ista":"Vandael DH, Borges Merjane C, Zhang X, Jonas PM. 2020. Short-term plasticity at hippocampal mossy fiber synapses is induced by natural activity patterns and associated with vesicle pool engram formation. Neuron. 107(3), 509–521."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","project":[{"grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glumatergic synapse","call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"},{"name":"The Wittgenstein Prize","grant_number":"Z00312","_id":"25C5A090-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"_id":"2696E7FE-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"V00739","name":"Structural plasticity at mossy fiber-CA3 synapses"}],"page":"509-521","doi":"10.1016/j.neuron.2020.05.013","date_published":"2020-08-05T00:00:00Z","date_created":"2020-06-22T13:29:05Z","isi":1,"has_accepted_license":"1","year":"2020","day":"05","publication":"Neuron","quality_controlled":"1","publisher":"Elsevier","oa":1,"acknowledgement":"This project received funding from the European Research Council (ERC) under the European Union Horizon 2020 Research and Innovation Program (grant agreement 692692 to P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung ( Z 312-B27 , Wittgenstein award to P.J. and V 739-B27 to C.B.-M.). We thank Drs. Jozsef Csicsvari, Jose Guzman, Erwin Neher, and Ryuichi Shigemoto for commenting on earlier versions of the manuscript. We are grateful to Walter Kaufmann, Daniel Gütl, and Vanessa Zheden for EM training; Alois Schlögl for programming; Florian Marr for excellent technical assistance and cell reconstruction; Christina Altmutter for technical help; Eleftheria Kralli-Beller for manuscript editing; Taija Makinen for providing the Prox1-CreERT2 mouse line; and the Scientific Service Units of IST Austria for support.","department":[{"_id":"PeJo"}],"file_date_updated":"2020-11-25T11:23:02Z","date_updated":"2023-08-22T07:45:25Z","ddc":["570"],"type":"journal_article","article_type":"original","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"status":"public","_id":"8001","volume":107,"issue":"3","related_material":{"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/possible-physical-trace-of-short-term-memory-found/"}]},"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","ec_funded":1,"publication_identifier":{"eissn":["10974199"],"issn":["0896-6273"]},"publication_status":"published","file":[{"success":1,"checksum":"4030b2be0c9625d54694a1e9fb00305e","file_id":"8811","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_name":"2020_Neuron_Vandael.pdf","date_created":"2020-11-25T11:23:02Z","file_size":4390833,"date_updated":"2020-11-25T11:23:02Z","creator":"dernst"}],"language":[{"iso":"eng"}],"scopus_import":"1","month":"08","intvolume":" 107","acknowledged_ssus":[{"_id":"SSU"}],"abstract":[{"text":"Post-tetanic potentiation (PTP) is an attractive candidate mechanism for hippocampus-dependent short-term memory. Although PTP has a uniquely large magnitude at hippocampal mossy fiber-CA3 pyramidal neuron synapses, it is unclear whether it can be induced by natural activity and whether its lifetime is sufficient to support short-term memory. We combined in vivo recordings from granule cells (GCs), in vitro paired recordings from mossy fiber terminals and postsynaptic CA3 neurons, and “flash and freeze” electron microscopy. PTP was induced at single synapses and showed a low induction threshold adapted to sparse GC activity in vivo. PTP was mainly generated by enlargement of the readily releasable pool of synaptic vesicles, allowing multiplicative interaction with other plasticity forms. PTP was associated with an increase in the docked vesicle pool, suggesting formation of structural “pool engrams.” Absence of presynaptic activity extended the lifetime of the potentiation, enabling prolonged information storage in the hippocampal network.","lang":"eng"}],"oa_version":"Published Version","pmid":1},{"_id":"8162","status":"public","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"type":"journal_article","article_type":"original","ddc":["570"],"date_updated":"2023-08-22T08:20:11Z","file_date_updated":"2020-12-02T09:26:46Z","department":[{"_id":"SiHi"}],"oa_version":"Published Version","acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"},{"_id":"PreCl"}],"abstract":[{"text":"In mammalian genomes, a subset of genes is regulated by genomic imprinting, resulting in silencing of one parental allele. Imprinting is essential for cerebral cortex development, but prevalence and functional impact in individual cells is unclear. Here, we determined allelic expression in cortical cell types and established a quantitative platform to interrogate imprinting in single cells. We created cells with uniparental chromosome disomy (UPD) containing two copies of either the maternal or the paternal chromosome; hence, imprinted genes will be 2-fold overexpressed or not expressed. By genetic labeling of UPD, we determined cellular phenotypes and transcriptional responses to deregulated imprinted gene expression at unprecedented single-cell resolution. We discovered an unexpected degree of cell-type specificity and a novel function of imprinting in the regulation of cortical astrocyte survival. More generally, our results suggest functional relevance of imprinted gene expression in glial astrocyte lineage and thus for generating cortical cell-type diversity.","lang":"eng"}],"intvolume":" 107","month":"09","scopus_import":"1","language":[{"iso":"eng"}],"file":[{"creator":"dernst","file_size":8911830,"date_updated":"2020-12-02T09:26:46Z","file_name":"2020_Neuron_Laukoter.pdf","date_created":"2020-12-02T09:26:46Z","relation":"main_file","access_level":"open_access","content_type":"application/pdf","success":1,"file_id":"8828","checksum":"7becdc16a6317304304631087ae7dd7f"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"ec_funded":1,"issue":"6","volume":107,"related_material":{"link":[{"description":"News on IST Website","relation":"press_release","url":"https://ist.ac.at/en/news/cells-react-differently-to-genomic-imprinting/"}]},"project":[{"_id":"2625A13E-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanisms of Radial Neuronal Migration","grant_number":"24812"},{"grant_number":"T0101031","name":"Role of Eed in neural stem cell lineage progression","call_identifier":"FWF","_id":"268F8446-B435-11E9-9278-68D0E5697425"},{"_id":"264E56E2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"M02416","name":"Molecular Mechanisms Regulating Gliogenesis in the Cerebral Cortex"},{"_id":"25D92700-B435-11E9-9278-68D0E5697425","name":"Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain","grant_number":"LS13-002"},{"_id":"25D7962E-B435-11E9-9278-68D0E5697425","name":"Quantitative Structure-Function Analysis of Cerebral Cortex Assembly at Clonal Level","grant_number":"RGP0053/2014"},{"_id":"25D61E48-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Molecular Mechanisms of Cerebral Cortex Development","grant_number":"618444"},{"_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ista":"Laukoter S, Pauler F, Beattie RJ, Amberg N, Hansen AH, Streicher C, Penz T, Bock C, Hippenmeyer S. 2020. Cell-type specificity of genomic imprinting in cerebral cortex. Neuron. 107(6), 1160–1179.e9.","chicago":"Laukoter, Susanne, Florian Pauler, Robert J Beattie, Nicole Amberg, Andi H Hansen, Carmen Streicher, Thomas Penz, Christoph Bock, and Simon Hippenmeyer. “Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.06.031.","ieee":"S. Laukoter et al., “Cell-type specificity of genomic imprinting in cerebral cortex,” Neuron, vol. 107, no. 6. Elsevier, p. 1160–1179.e9, 2020.","short":"S. Laukoter, F. Pauler, R.J. Beattie, N. Amberg, A.H. Hansen, C. Streicher, T. Penz, C. Bock, S. Hippenmeyer, Neuron 107 (2020) 1160–1179.e9.","ama":"Laukoter S, Pauler F, Beattie RJ, et al. Cell-type specificity of genomic imprinting in cerebral cortex. Neuron. 2020;107(6):1160-1179.e9. doi:10.1016/j.neuron.2020.06.031","apa":"Laukoter, S., Pauler, F., Beattie, R. J., Amberg, N., Hansen, A. H., Streicher, C., … Hippenmeyer, S. (2020). Cell-type specificity of genomic imprinting in cerebral cortex. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.06.031","mla":"Laukoter, Susanne, et al. “Cell-Type Specificity of Genomic Imprinting in Cerebral Cortex.” Neuron, vol. 107, no. 6, Elsevier, 2020, p. 1160–1179.e9, doi:10.1016/j.neuron.2020.06.031."},"title":"Cell-type specificity of genomic imprinting in cerebral cortex","external_id":{"isi":["000579698700006"]},"article_processing_charge":"No","author":[{"orcid":"0000-0002-7903-3010","full_name":"Laukoter, Susanne","last_name":"Laukoter","id":"2D6B7A9A-F248-11E8-B48F-1D18A9856A87","first_name":"Susanne"},{"id":"48EA0138-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","last_name":"Pauler","orcid":"0000-0002-7462-0048","full_name":"Pauler, Florian"},{"id":"2E26DF60-F248-11E8-B48F-1D18A9856A87","first_name":"Robert J","orcid":"0000-0002-8483-8753","full_name":"Beattie, Robert J","last_name":"Beattie"},{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","first_name":"Nicole","last_name":"Amberg","full_name":"Amberg, Nicole","orcid":"0000-0002-3183-8207"},{"id":"38853E16-F248-11E8-B48F-1D18A9856A87","first_name":"Andi H","full_name":"Hansen, Andi H","last_name":"Hansen"},{"last_name":"Streicher","full_name":"Streicher, Carmen","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","first_name":"Carmen"},{"full_name":"Penz, Thomas","last_name":"Penz","first_name":"Thomas"},{"last_name":"Bock","orcid":"0000-0001-6091-3088","full_name":"Bock, Christoph","first_name":"Christoph"},{"last_name":"Hippenmeyer","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon"}],"acknowledgement":"We thank A. Heger (IST Austria Preclinical Facility), A. Sommer and C. Czepe (VBCF GmbH, NGS Unit), and A. Seitz and P. Moll (Lexogen GmbH) for technical support; G. Arque, S. Resch, C. Igler, C. Dotter, C. Yahya, Q. Hudson, and D. Andergassen for initial experiments and/or assistance; D. Barlow, O. Bell, and all members of the Hippenmeyer lab for discussion; and N. Barton, B. Vicoso, M. Sixt, and L. Luo for comments on earlier versions of the manuscript. This research was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Bioimaging Facilities (BIF), Life Science Facilities (LSF), and Preclinical Facilities (PCF). A.H.H. is a recipient of a DOC fellowship (24812) of the Austrian Academy of Sciences. N.A. received support from the FWF Firnberg-Programm (T 1031). R.B. received support from the FWF Meitner-Programm (M 2416). This work was also supported by IST Austria institutional funds; a NÖ Forschung und Bildung n[f+b] life science call grant (C13-002) to S.H.; a program grant from the Human Frontiers Science Program (RGP0053/2014) to S.H.; the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement 618444 to S.H.; and the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 725780 LinPro) to S.H.","oa":1,"publisher":"Elsevier","quality_controlled":"1","publication":"Neuron","day":"23","year":"2020","has_accepted_license":"1","isi":1,"date_created":"2020-07-23T16:03:12Z","date_published":"2020-09-23T00:00:00Z","doi":"10.1016/j.neuron.2020.06.031","page":"1160-1179.e9"},{"date_updated":"2023-08-22T08:30:55Z","ddc":["570"],"department":[{"_id":"PeJo"},{"_id":"ScienComp"}],"file_date_updated":"2020-12-04T09:29:21Z","_id":"8261","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"type":"journal_article","article_type":"original","status":"public","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","access_level":"open_access","relation":"main_file","checksum":"44a5960fc083a4cb3488d22224859fdc","file_id":"8920","success":1,"date_updated":"2020-12-04T09:29:21Z","file_size":3011120,"creator":"dernst","date_created":"2020-12-04T09:29:21Z","file_name":"2020_Neuron_Zhang.pdf"}],"ec_funded":1,"volume":107,"related_material":{"link":[{"description":"News on IST Website","relation":"press_release","url":"https://ist.ac.at/en/news/the-bouncer-in-the-brain/"}]},"issue":"6","abstract":[{"text":"Dentate gyrus granule cells (GCs) connect the entorhinal cortex to the hippocampal CA3 region, but how they process spatial information remains enigmatic. To examine the role of GCs in spatial coding, we measured excitatory postsynaptic potentials (EPSPs) and action potentials (APs) in head-fixed mice running on a linear belt. Intracellular recording from morphologically identified GCs revealed that most cells were active, but activity level varied over a wide range. Whereas only ∼5% of GCs showed spatially tuned spiking, ∼50% received spatially tuned input. Thus, the GC population broadly encodes spatial information, but only a subset relays this information to the CA3 network. Fourier analysis indicated that GCs received conjunctive place-grid-like synaptic input, suggesting code conversion in single neurons. GC firing was correlated with dendritic complexity and intrinsic excitability, but not extrinsic excitatory input or dendritic cable properties. Thus, functional maturation may control input-output transformation and spatial code conversion.","lang":"eng"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"ScienComp"},{"_id":"PreCl"}],"pmid":1,"oa_version":"Published Version","intvolume":" 107","month":"09","citation":{"ista":"Zhang X, Schlögl A, Jonas PM. 2020. Selective routing of spatial information flow from input to output in hippocampal granule cells. Neuron. 107(6), 1212–1225.","chicago":"Zhang, Xiaomin, Alois Schlögl, and Peter M Jonas. “Selective Routing of Spatial Information Flow from Input to Output in Hippocampal Granule Cells.” Neuron. Elsevier, 2020. https://doi.org/10.1016/j.neuron.2020.07.006.","ieee":"X. Zhang, A. Schlögl, and P. M. Jonas, “Selective routing of spatial information flow from input to output in hippocampal granule cells,” Neuron, vol. 107, no. 6. Elsevier, pp. 1212–1225, 2020.","short":"X. Zhang, A. Schlögl, P.M. Jonas, Neuron 107 (2020) 1212–1225.","ama":"Zhang X, Schlögl A, Jonas PM. Selective routing of spatial information flow from input to output in hippocampal granule cells. Neuron. 2020;107(6):1212-1225. doi:10.1016/j.neuron.2020.07.006","apa":"Zhang, X., Schlögl, A., & Jonas, P. M. (2020). Selective routing of spatial information flow from input to output in hippocampal granule cells. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2020.07.006","mla":"Zhang, Xiaomin, et al. “Selective Routing of Spatial Information Flow from Input to Output in Hippocampal Granule Cells.” Neuron, vol. 107, no. 6, Elsevier, 2020, pp. 1212–25, doi:10.1016/j.neuron.2020.07.006."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000579698700009"],"pmid":["32763145"]},"article_processing_charge":"No","author":[{"id":"423EC9C2-F248-11E8-B48F-1D18A9856A87","first_name":"Xiaomin","last_name":"Zhang","full_name":"Zhang, Xiaomin"},{"last_name":"Schlögl","orcid":"0000-0002-5621-8100","full_name":"Schlögl, Alois","id":"45BF87EE-F248-11E8-B48F-1D18A9856A87","first_name":"Alois"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas"}],"title":"Selective routing of spatial information flow from input to output in hippocampal granule cells","project":[{"name":"Biophysics and circuit function of a giant cortical glumatergic synapse","grant_number":"692692","call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"},{"grant_number":"Z00312","name":"The Wittgenstein Prize","_id":"25C5A090-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"year":"2020","isi":1,"has_accepted_license":"1","publication":"Neuron","day":"23","page":"1212-1225","date_created":"2020-08-14T09:36:05Z","date_published":"2020-09-23T00:00:00Z","doi":"10.1016/j.neuron.2020.07.006","acknowledgement":"This project has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement 692692, P.J.) and the Fond zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award, P.J.). We thank Gyorgy Buzsáki, Jozsef Csicsvari, Juan Ramirez Villegas, and Federico Stella for commenting on earlier versions of this manuscript. We also thank Katie Bittner, Michael Brecht, Albert Lee, Jeffery Magee, and Alejandro Pernía-Andrade for sharing expertise in in vivo patch-clamp recording. We are grateful to Florian Marr for cell labeling, cell reconstruction, and technical assistance; Ben Suter for helpful discussions; Christina Altmutter for technical support; Eleftheria Kralli-Beller for manuscript editing; and Todor Asenov (Machine Shop) for device construction. We also thank the Scientific Service Units (SSUs) of IST Austria (Machine Shop, Scientific Computing, and Preclinical Facility) for efficient support.","oa":1,"publisher":"Elsevier","quality_controlled":"1"},{"intvolume":" 105","month":"03","scopus_import":"1","pmid":1,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"How structural and functional properties of synapses relate to each other is a fundamental question in neuroscience. Electrophysiology has elucidated mechanisms of synaptic transmission, and electron microscopy (EM) has provided insight into morphological properties of synapses. Here we describe an enhanced method for functional EM (“flash and freeze”), combining optogenetic stimulation with high-pressure freezing. We demonstrate that the improved method can be applied to intact networks in acute brain slices and organotypic slice cultures from mice. As a proof of concept, we probed vesicle pool changes during synaptic transmission at the hippocampal mossy fiber-CA3 pyramidal neuron synapse. Our findings show overlap of the docked vesicle pool and the functionally defined readily releasable pool and provide evidence of fast endocytosis at this synapse. Functional EM with acute slices and slice cultures has the potential to reveal the structural and functional mechanisms of transmission in intact, genetically perturbed, and disease-affected synapses."}],"ec_funded":1,"volume":105,"related_material":{"record":[{"id":"11196","status":"public","relation":"dissertation_contains"}],"link":[{"description":"News on IST Homepage","relation":"press_release","url":"https://ist.ac.at/en/news/flash-and-freeze-reveals-dynamics-of-nerve-connections/"}]},"language":[{"iso":"eng"}],"file":[{"success":1,"file_id":"8778","checksum":"3582664addf26859e86ac5bec3e01416","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_name":"2020_Neuron_BorgesMerjane.pdf","date_created":"2020-11-20T08:58:53Z","creator":"dernst","file_size":9712957,"date_updated":"2020-11-20T08:58:53Z"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"status":"public","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"article_type":"original","type":"journal_article","_id":"7473","department":[{"_id":"PeJo"}],"file_date_updated":"2020-11-20T08:58:53Z","ddc":["570"],"date_updated":"2024-03-27T23:30:07Z","oa":1,"quality_controlled":"1","publisher":"Elsevier","acknowledgement":"This project has received funding from the European Research Council (ERC) and European Commission (EC), under the European Union’s Horizon 2020 research and innovation programme (ERC grant agreement No. 692692 and Marie Sklodowska-Curie 708497) and from Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27 Wittgenstein award and DK W1205-B09). We thank Johann Danzl and Ryuichi Shigemoto for critically reading the manuscript; Walter Kaufmann, Daniel Gutl, and Vanessa Zheden for extensive EM training, advice, and experimental assistance; Benjamin Suter for substantial help with light stimulation, ImageJ plugins for analysis, and manuscript editing; Florian Marr and Christina Altmutter for technical support; Eleftheria Kralli-Beller for manuscript editing; Julia König and Paul Wurzinger (Leica Microsystems) for helpful technical discussions; and Taija Makinen for providing the Prox1-CreERT2 mouse line.","date_created":"2020-02-10T15:59:45Z","date_published":"2020-03-18T00:00:00Z","doi":"10.1016/j.neuron.2019.12.022","page":"992-1006","publication":"Neuron","day":"18","year":"2020","has_accepted_license":"1","isi":1,"project":[{"call_identifier":"H2020","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692","name":"Biophysics and circuit function of a giant cortical glumatergic synapse"},{"name":"Presynaptic calcium channels distribution and impact on coupling at the hippocampal mossy fiber synapse","grant_number":"708497","_id":"25BAF7B2-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"},{"name":"The Wittgenstein Prize","grant_number":"Z00312","_id":"25C5A090-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"},{"grant_number":"W01205","name":"Zellkommunikation in Gesundheit und Krankheit","_id":"25C3DBB6-B435-11E9-9278-68D0E5697425","call_identifier":"FWF"}],"title":"Functional electron microscopy (“Flash and Freeze”) of identified cortical synapses in acute brain slices","external_id":{"isi":["000520854700008"],"pmid":["31928842"]},"article_processing_charge":"No","author":[{"id":"4305C450-F248-11E8-B48F-1D18A9856A87","first_name":"Carolina","last_name":"Borges Merjane","full_name":"Borges Merjane, Carolina","orcid":"0000-0003-0005-401X"},{"last_name":"Kim","full_name":"Kim, Olena","first_name":"Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Jonas","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"chicago":"Borges Merjane, Carolina, Olena Kim, and Peter M Jonas. “Functional Electron Microscopy (‘Flash and Freeze’) of Identified Cortical Synapses in Acute Brain Slices.” Neuron. 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Jonas, Neuron 105 (2020) 992–1006.","ieee":"C. Borges Merjane, O. Kim, and P. M. Jonas, “Functional electron microscopy (‘Flash and Freeze’) of identified cortical synapses in acute brain slices,” Neuron, vol. 105. Elsevier, pp. 992–1006, 2020."}},{"department":[{"_id":"RySh"}],"date_updated":"2023-08-30T07:28:22Z","ddc":["571","599"],"article_type":"original","type":"journal_article","status":"public","_id":"7099","volume":104,"issue":"4","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2019.08.013"}],"scopus_import":"1","intvolume":" 104","month":"11","pmid":1,"oa_version":"Published Version","external_id":{"isi":["000497963500017"],"pmid":["31543297"]},"article_processing_charge":"No","author":[{"first_name":"Yu","last_name":"Kasugai","full_name":"Kasugai, Yu"},{"first_name":"Elisabeth","full_name":"Vogel, Elisabeth","last_name":"Vogel"},{"full_name":"Hörtnagl, Heide","last_name":"Hörtnagl","first_name":"Heide"},{"first_name":"Sabine","full_name":"Schönherr, Sabine","last_name":"Schönherr"},{"full_name":"Paradiso, Enrica","last_name":"Paradiso","first_name":"Enrica"},{"first_name":"Markus","full_name":"Hauschild, Markus","last_name":"Hauschild"},{"first_name":"Georg","last_name":"Göbel","full_name":"Göbel, Georg"},{"full_name":"Milenkovic, Ivan","last_name":"Milenkovic","first_name":"Ivan"},{"first_name":"Yvan","full_name":"Peterschmitt, Yvan","last_name":"Peterschmitt"},{"first_name":"Ramon","last_name":"Tasan","full_name":"Tasan, Ramon"},{"last_name":"Sperk","full_name":"Sperk, Günther","first_name":"Günther"},{"orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Werner","last_name":"Sieghart","full_name":"Sieghart, Werner"},{"last_name":"Singewald","full_name":"Singewald, Nicolas","first_name":"Nicolas"},{"full_name":"Lüthi, Andreas","last_name":"Lüthi","first_name":"Andreas"},{"last_name":"Ferraguti","full_name":"Ferraguti, Francesco","first_name":"Francesco"}],"title":"Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning","citation":{"mla":"Kasugai, Yu, et al. “Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning.” Neuron, vol. 104, no. 4, Elsevier, 2019, p. 781–794.e4, doi:10.1016/j.neuron.2019.08.013.","ieee":"Y. Kasugai et al., “Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning,” Neuron, vol. 104, no. 4. Elsevier, p. 781–794.e4, 2019.","short":"Y. Kasugai, E. Vogel, H. Hörtnagl, S. Schönherr, E. Paradiso, M. Hauschild, G. Göbel, I. Milenkovic, Y. Peterschmitt, R. Tasan, G. Sperk, R. Shigemoto, W. Sieghart, N. Singewald, A. Lüthi, F. Ferraguti, Neuron 104 (2019) 781–794.e4.","ama":"Kasugai Y, Vogel E, Hörtnagl H, et al. Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. Neuron. 2019;104(4):781-794.e4. doi:10.1016/j.neuron.2019.08.013","apa":"Kasugai, Y., Vogel, E., Hörtnagl, H., Schönherr, S., Paradiso, E., Hauschild, M., … Ferraguti, F. (2019). Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.08.013","chicago":"Kasugai, Yu, Elisabeth Vogel, Heide Hörtnagl, Sabine Schönherr, Enrica Paradiso, Markus Hauschild, Georg Göbel, et al. “Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.08.013.","ista":"Kasugai Y, Vogel E, Hörtnagl H, Schönherr S, Paradiso E, Hauschild M, Göbel G, Milenkovic I, Peterschmitt Y, Tasan R, Sperk G, Shigemoto R, Sieghart W, Singewald N, Lüthi A, Ferraguti F. 2019. Structural and functional remodeling of amygdala GABAergic synapses in associative fear learning. Neuron. 104(4), 781–794.e4."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"781-794.e4","date_created":"2019-11-25T08:02:39Z","date_published":"2019-11-20T00:00:00Z","doi":"10.1016/j.neuron.2019.08.013","year":"2019","isi":1,"has_accepted_license":"1","publication":"Neuron","day":"20","oa":1,"publisher":"Elsevier","quality_controlled":"1","acknowledgement":"The authors thank Gabi Schmid for excellent technical support. We also thank\r\nDr. H. Harada, Dr. W. Kaufmann, and Dr. B. Kapelari for testing the specificity\r\nof some of the antibodies used in this study on replicas. Funding was provided\r\nby the Austrian Science Fund (Fonds zur Fo¨ rderung der Wissenschaftlichen\r\nForschung) Sonderforschungsbereich grants F44-17 (to F.jF.), F44-10 and\r\nP25375-B24 (to N.S.), and P26680 (to G.S.) and by the Novartis Research\r\nFoundation and the Swiss National Science Foundation (to A.L). We also thank\r\nProf. M. Capogna for reading a previous version of the manuscript."},{"tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"type":"journal_article","status":"public","_id":"6454","file_date_updated":"2020-07-14T12:47:30Z","department":[{"_id":"SiHi"}],"date_updated":"2023-09-05T13:02:21Z","ddc":["570"],"scopus_import":"1","intvolume":" 102","month":"04","abstract":[{"lang":"eng","text":"Adult neural stem cells and multiciliated ependymalcells are glial cells essential for neurological func-tions. Together, they make up the adult neurogenicniche. Using both high-throughput clonal analysisand single-cell resolution of progenitor division pat-terns and fate, we show that these two componentsof the neurogenic niche are lineally related: adult neu-ral stem cells are sister cells to ependymal cells,whereas most ependymal cells arise from the termi-nal symmetric divisions of the lineage. Unexpectedly,we found that the antagonist regulators of DNA repli-cation, GemC1 and Geminin, can tune the proportionof neural stem cells and ependymal cells. Our find-ings reveal the controlled dynamic of the neurogenicniche ontogeny and identify the Geminin familymembers as key regulators of the initial pool of adultneural stem cells."}],"pmid":1,"oa_version":"Published Version","ec_funded":1,"volume":102,"issue":"1","publication_status":"published","publication_identifier":{"eissn":["1097-4199"],"issn":["0896-6273"]},"language":[{"iso":"eng"}],"file":[{"checksum":"1fb6e195c583eb0c5cabf26f69ff6675","file_id":"6457","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_name":"2019_Neuron_Ortiz.pdf","date_created":"2019-05-15T09:28:41Z","file_size":7288572,"date_updated":"2020-07-14T12:47:30Z","creator":"dernst"}],"project":[{"_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","grant_number":"725780"}],"external_id":{"pmid":["30824354"],"isi":["000463337900018"]},"article_processing_charge":"No","author":[{"first_name":"G","last_name":"Ortiz-Álvarez","full_name":"Ortiz-Álvarez, G"},{"last_name":"Daclin","full_name":"Daclin, M","first_name":"M"},{"first_name":"A","full_name":"Shihavuddin, A","last_name":"Shihavuddin"},{"full_name":"Lansade, P","last_name":"Lansade","first_name":"P"},{"last_name":"Fortoul","full_name":"Fortoul, A","first_name":"A"},{"full_name":"Faucourt, M","last_name":"Faucourt","first_name":"M"},{"last_name":"Clavreul","full_name":"Clavreul, S","first_name":"S"},{"last_name":"Lalioti","full_name":"Lalioti, ME","first_name":"ME"},{"first_name":"S","full_name":"Taraviras, S","last_name":"Taraviras"},{"first_name":"Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","last_name":"Hippenmeyer"},{"full_name":"Livet, J","last_name":"Livet","first_name":"J"},{"first_name":"A","full_name":"Meunier, A","last_name":"Meunier"},{"full_name":"Genovesio, A","last_name":"Genovesio","first_name":"A"},{"first_name":"N","last_name":"Spassky","full_name":"Spassky, N"}],"title":"Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members","citation":{"mla":"Ortiz-Álvarez, G., et al. “Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.” Neuron, vol. 102, no. 1, Elsevier, 2019, p. 159–172.e7, doi:10.1016/j.neuron.2019.01.051.","ama":"Ortiz-Álvarez G, Daclin M, Shihavuddin A, et al. Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members. Neuron. 2019;102(1):159-172.e7. doi:10.1016/j.neuron.2019.01.051","apa":"Ortiz-Álvarez, G., Daclin, M., Shihavuddin, A., Lansade, P., Fortoul, A., Faucourt, M., … Spassky, N. (2019). Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2019.01.051","ieee":"G. Ortiz-Álvarez et al., “Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members,” Neuron, vol. 102, no. 1. Elsevier, p. 159–172.e7, 2019.","short":"G. Ortiz-Álvarez, M. Daclin, A. Shihavuddin, P. Lansade, A. Fortoul, M. Faucourt, S. Clavreul, M. Lalioti, S. Taraviras, S. Hippenmeyer, J. Livet, A. Meunier, A. Genovesio, N. Spassky, Neuron 102 (2019) 159–172.e7.","chicago":"Ortiz-Álvarez, G, M Daclin, A Shihavuddin, P Lansade, A Fortoul, M Faucourt, S Clavreul, et al. “Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.” Neuron. Elsevier, 2019. https://doi.org/10.1016/j.neuron.2019.01.051.","ista":"Ortiz-Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M, Clavreul S, Lalioti M, Taraviras S, Hippenmeyer S, Livet J, Meunier A, Genovesio A, Spassky N. 2019. Adult neural stem cells and multiciliated ependymal cells share a common lineage regulated by the Geminin family members. Neuron. 102(1), 159–172.e7."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","oa":1,"publisher":"Elsevier","quality_controlled":"1","page":"159-172.e7","date_created":"2019-05-14T13:06:30Z","date_published":"2019-04-03T00:00:00Z","doi":"10.1016/j.neuron.2019.01.051","year":"2019","isi":1,"has_accepted_license":"1","publication":"Neuron","day":"03"},{"extern":"1","date_updated":"2021-01-12T08:16:31Z","_id":"8015","status":"public","article_type":"original","type":"journal_article","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"issue":"1","volume":98,"oa_version":"Published Version","pmid":1,"abstract":[{"text":"The neural code of cortical processing remains uncracked; however, it must necessarily rely on faithful signal propagation between cortical areas. In this issue of Neuron, Joglekar et al. (2018) show that strong inter-areal excitation balanced by local inhibition can enable reliable signal propagation in data-constrained network models of macaque cortex. ","lang":"eng"}],"intvolume":" 98","month":"04","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.neuron.2018.03.028"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"short":"J.P. Stroud, T.P. Vogels, Neuron 98 (2018) 8–9.","ieee":"J. P. Stroud and T. P. Vogels, “Cortical signal propagation: Balance, amplify, transmit,” Neuron, vol. 98, no. 1. Elsevier, pp. 8–9, 2018.","ama":"Stroud JP, Vogels TP. Cortical signal propagation: Balance, amplify, transmit. Neuron. 2018;98(1):8-9. doi:10.1016/j.neuron.2018.03.028","apa":"Stroud, J. P., & Vogels, T. P. (2018). Cortical signal propagation: Balance, amplify, transmit. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2018.03.028","mla":"Stroud, Jake P., and Tim P. Vogels. “Cortical Signal Propagation: Balance, Amplify, Transmit.” Neuron, vol. 98, no. 1, Elsevier, 2018, pp. 8–9, doi:10.1016/j.neuron.2018.03.028.","ista":"Stroud JP, Vogels TP. 2018. Cortical signal propagation: Balance, amplify, transmit. Neuron. 98(1), 8–9.","chicago":"Stroud, Jake P., and Tim P Vogels. “Cortical Signal Propagation: Balance, Amplify, Transmit.” Neuron. Elsevier, 2018. https://doi.org/10.1016/j.neuron.2018.03.028."},"title":"Cortical signal propagation: Balance, amplify, transmit","external_id":{"pmid":["29621492"]},"article_processing_charge":"No","author":[{"first_name":"Jake P.","full_name":"Stroud, Jake P.","last_name":"Stroud"},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","first_name":"Tim P","orcid":"0000-0003-3295-6181","full_name":"Vogels, Tim P","last_name":"Vogels"}],"publication":"Neuron","day":"04","year":"2018","date_created":"2020-06-25T12:53:39Z","date_published":"2018-04-04T00:00:00Z","doi":"10.1016/j.neuron.2018.03.028","page":"8-9","oa":1,"publisher":"Elsevier","quality_controlled":"1"},{"date_created":"2020-04-30T10:35:13Z","issue":"2","doi":"10.1016/j.neuron.2017.12.029","volume":97,"date_published":"2018-01-04T00:00:00Z","page":"341-355.e3","language":[{"iso":"eng"}],"publication":"Neuron","day":"04","publication_status":"published","year":"2018","publication_identifier":{"issn":["0896-6273"]},"intvolume":" 97","month":"01","publisher":"Elsevier","quality_controlled":"1","oa_version":"None","abstract":[{"text":"Motor output varies along the rostro-caudal axis of the tetrapod spinal cord. At limb levels, ∼60 motor pools control the alternation of flexor and extensor muscles about each joint, whereas at thoracic levels as few as 10 motor pools supply muscle groups that support posture, inspiration, and expiration. Whether such differences in motor neuron identity and muscle number are associated with segmental distinctions in interneuron diversity has not been resolved. We show that select combinations of nineteen transcription factors that specify lumbar V1 inhibitory interneurons generate subpopulations enriched at limb and thoracic levels. Specification of limb and thoracic V1 interneurons involves the Hox gene Hoxc9 independently of motor neurons. Thus, early Hox patterning of the spinal cord determines the identity of V1 interneurons and motor neurons. These studies reveal a developmental program of V1 interneuron diversity, providing insight into the organization of inhibitory interneurons associated with differential motor output.","lang":"eng"}],"title":"Origin and segmental diversity of spinal inhibitory interneurons","article_processing_charge":"No","author":[{"id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","first_name":"Lora Beatrice Jaeger","full_name":"Sweeney, Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601","last_name":"Sweeney"},{"last_name":"Bikoff","full_name":"Bikoff, Jay B.","first_name":"Jay B."},{"full_name":"Gabitto, Mariano I.","last_name":"Gabitto","first_name":"Mariano I."},{"last_name":"Brenner-Morton","full_name":"Brenner-Morton, Susan","first_name":"Susan"},{"last_name":"Baek","full_name":"Baek, Myungin","first_name":"Myungin"},{"full_name":"Yang, Jerry H.","last_name":"Yang","first_name":"Jerry H."},{"full_name":"Tabak, Esteban G.","last_name":"Tabak","first_name":"Esteban G."},{"first_name":"Jeremy S.","full_name":"Dasen, Jeremy S.","last_name":"Dasen"},{"first_name":"Christopher R.","last_name":"Kintner","full_name":"Kintner, Christopher R."},{"first_name":"Thomas M.","full_name":"Jessell, Thomas M.","last_name":"Jessell"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","citation":{"mla":"Sweeney, Lora B., et al. “Origin and Segmental Diversity of Spinal Inhibitory Interneurons.” Neuron, vol. 97, no. 2, Elsevier, 2018, p. 341–355.e3, doi:10.1016/j.neuron.2017.12.029.","ieee":"L. B. Sweeney et al., “Origin and segmental diversity of spinal inhibitory interneurons,” Neuron, vol. 97, no. 2. Elsevier, p. 341–355.e3, 2018.","short":"L.B. Sweeney, J.B. Bikoff, M.I. Gabitto, S. Brenner-Morton, M. Baek, J.H. Yang, E.G. Tabak, J.S. Dasen, C.R. Kintner, T.M. Jessell, Neuron 97 (2018) 341–355.e3.","ama":"Sweeney LB, Bikoff JB, Gabitto MI, et al. Origin and segmental diversity of spinal inhibitory interneurons. Neuron. 2018;97(2):341-355.e3. doi:10.1016/j.neuron.2017.12.029","apa":"Sweeney, L. B., Bikoff, J. B., Gabitto, M. I., Brenner-Morton, S., Baek, M., Yang, J. H., … Jessell, T. M. (2018). Origin and segmental diversity of spinal inhibitory interneurons. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2017.12.029","chicago":"Sweeney, Lora B., Jay B. Bikoff, Mariano I. Gabitto, Susan Brenner-Morton, Myungin Baek, Jerry H. Yang, Esteban G. Tabak, Jeremy S. Dasen, Christopher R. Kintner, and Thomas M. Jessell. “Origin and Segmental Diversity of Spinal Inhibitory Interneurons.” Neuron. Elsevier, 2018. https://doi.org/10.1016/j.neuron.2017.12.029.","ista":"Sweeney LB, Bikoff JB, Gabitto MI, Brenner-Morton S, Baek M, Yang JH, Tabak EG, Dasen JS, Kintner CR, Jessell TM. 2018. Origin and segmental diversity of spinal inhibitory interneurons. Neuron. 97(2), 341–355.e3."},"date_updated":"2024-01-31T10:13:54Z","status":"public","type":"journal_article","article_type":"original","_id":"7698"},{"language":[{"iso":"eng"}],"file":[{"checksum":"49fbca2821066c0965bd5678b32b6b48","file_id":"8103","content_type":"application/pdf","access_level":"open_access","relation":"main_file","date_created":"2020-07-09T09:42:49Z","file_name":"2017_Neuron_Costa.pdf","date_updated":"2020-07-14T12:48:08Z","file_size":7140149,"creator":"cziletti"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"volume":96,"issue":"1","oa_version":"Published Version","pmid":1,"abstract":[{"text":"Long-term modifications of neuronal connections are critical for reliable memory storage in the brain. However, their locus of expression—pre- or postsynaptic—is highly variable. Here we introduce a theoretical framework in which long-term plasticity performs an optimization of the postsynaptic response statistics toward a given mean with minimal variance. Consequently, the state of the synapse at the time of plasticity induction determines the ratio of pre- and postsynaptic modifications. Our theory explains the experimentally observed expression loci of the hippocampal and neocortical synaptic potentiation studies we examined. Moreover, the theory predicts presynaptic expression of long-term depression, consistent with experimental observations. At inhibitory synapses, the theory suggests a statistically efficient excitatory-inhibitory balance in which changes in inhibitory postsynaptic response statistics specifically target the mean excitation. Our results provide a unifying theory for understanding the expression mechanisms and functions of long-term synaptic transmission plasticity.","lang":"eng"}],"intvolume":" 96","month":"09","ddc":["570"],"extern":"1","date_updated":"2021-01-12T08:16:32Z","file_date_updated":"2020-07-14T12:48:08Z","_id":"8016","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","article_type":"original","publication":"Neuron","day":"27","year":"2017","has_accepted_license":"1","date_created":"2020-06-25T12:54:46Z","date_published":"2017-09-27T00:00:00Z","doi":"10.1016/j.neuron.2017.09.021","page":"177-189.e7","oa":1,"quality_controlled":"1","publisher":"Elsevier","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","citation":{"ista":"Costa RP, Padamsey Z, D’Amour JA, Emptage NJ, Froemke RC, Vogels TP. 2017. Synaptic transmission optimization predicts expression loci of long-term plasticity. Neuron. 96(1), 177–189.e7.","chicago":"Costa, Rui Ponte, Zahid Padamsey, James A. D’Amour, Nigel J. Emptage, Robert C. Froemke, and Tim P Vogels. “Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity.” Neuron. Elsevier, 2017. https://doi.org/10.1016/j.neuron.2017.09.021.","short":"R.P. Costa, Z. Padamsey, J.A. D’Amour, N.J. Emptage, R.C. Froemke, T.P. Vogels, Neuron 96 (2017) 177–189.e7.","ieee":"R. P. Costa, Z. Padamsey, J. A. D’Amour, N. J. Emptage, R. C. Froemke, and T. P. Vogels, “Synaptic transmission optimization predicts expression loci of long-term plasticity,” Neuron, vol. 96, no. 1. Elsevier, p. 177–189.e7, 2017.","apa":"Costa, R. P., Padamsey, Z., D’Amour, J. A., Emptage, N. J., Froemke, R. C., & Vogels, T. P. (2017). Synaptic transmission optimization predicts expression loci of long-term plasticity. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2017.09.021","ama":"Costa RP, Padamsey Z, D’Amour JA, Emptage NJ, Froemke RC, Vogels TP. Synaptic transmission optimization predicts expression loci of long-term plasticity. Neuron. 2017;96(1):177-189.e7. doi:10.1016/j.neuron.2017.09.021","mla":"Costa, Rui Ponte, et al. “Synaptic Transmission Optimization Predicts Expression Loci of Long-Term Plasticity.” Neuron, vol. 96, no. 1, Elsevier, 2017, p. 177–189.e7, doi:10.1016/j.neuron.2017.09.021."},"title":"Synaptic transmission optimization predicts expression loci of long-term plasticity","external_id":{"pmid":["28957667"]},"article_processing_charge":"No","author":[{"full_name":"Costa, Rui Ponte","last_name":"Costa","first_name":"Rui Ponte"},{"first_name":"Zahid","full_name":"Padamsey, Zahid","last_name":"Padamsey"},{"last_name":"D’Amour","full_name":"D’Amour, James A.","first_name":"James A."},{"last_name":"Emptage","full_name":"Emptage, Nigel J.","first_name":"Nigel J."},{"first_name":"Robert C.","full_name":"Froemke, Robert C.","last_name":"Froemke"},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","first_name":"Tim P","full_name":"Vogels, Tim P","orcid":"0000-0003-3295-6181","last_name":"Vogels"}]},{"abstract":[{"lang":"eng","text":"Balance of cortical excitation and inhibition (EI) is thought to be disrupted in several neuropsychiatric conditions, yet it is not clear how it is maintained in the healthy human brain. When EI balance is disturbed during learning and memory in animal models, it can be restabilized via formation of inhibitory replicas of newly formed excitatory connections. Here we assess evidence for such selective inhibitory rebalancing in humans. Using fMRI repetition suppression we measure newly formed cortical associations in the human brain. We show that expression of these associations reduces over time despite persistence in behavior, consistent with inhibitory rebalancing. To test this, we modulated excitation/inhibition balance with transcranial direct current stimulation (tDCS). Using ultra-high-field (7T) MRI and spectroscopy, we show that reducing GABA allows cortical associations to be re-expressed. This suggests that in humans associative memories are stored in balanced excitatory-inhibitory ensembles that lie dormant unless latent inhibitory connections are unmasked."}],"oa_version":"Published Version","pmid":1,"month":"04","intvolume":" 90","publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","file":[{"file_name":"2016_Neuron_Barron.pdf","date_created":"2020-07-09T09:57:04Z","creator":"cziletti","file_size":5334136,"date_updated":"2020-07-14T12:48:08Z","checksum":"9ce7a1c64986dce0435c070285a7ef9b","file_id":"8104","relation":"main_file","access_level":"open_access","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"issue":"1","volume":90,"_id":"8020","article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","date_updated":"2021-01-12T08:16:34Z","extern":"1","ddc":["570"],"file_date_updated":"2020-07-14T12:48:08Z","quality_controlled":"1","publisher":"Elsevier","oa":1,"has_accepted_license":"1","year":"2016","day":"06","publication":"Neuron","page":"191-203","date_published":"2016-04-06T00:00:00Z","doi":"10.1016/j.neuron.2016.02.031","date_created":"2020-06-25T13:05:33Z","citation":{"mla":"Barron, H. C., et al. “Unmasking Latent Inhibitory Connections in Human Cortex to Reveal Dormant Cortical Memories.” Neuron, vol. 90, no. 1, Elsevier, 2016, pp. 191–203, doi:10.1016/j.neuron.2016.02.031.","ieee":"H. C. Barron et al., “Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories,” Neuron, vol. 90, no. 1. Elsevier, pp. 191–203, 2016.","short":"H.C. Barron, T.P. Vogels, U.E. Emir, T.R. Makin, J. O’Shea, S. Clare, S. Jbabdi, R.J. Dolan, T.E.J. Behrens, Neuron 90 (2016) 191–203.","ama":"Barron HC, Vogels TP, Emir UE, et al. Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. Neuron. 2016;90(1):191-203. doi:10.1016/j.neuron.2016.02.031","apa":"Barron, H. C., Vogels, T. P., Emir, U. E., Makin, T. R., O’Shea, J., Clare, S., … Behrens, T. E. J. (2016). Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2016.02.031","chicago":"Barron, H.C., Tim P Vogels, U.E. Emir, T.R. Makin, J. O’Shea, S. Clare, S. Jbabdi, R.J. Dolan, and T.E.J. Behrens. “Unmasking Latent Inhibitory Connections in Human Cortex to Reveal Dormant Cortical Memories.” Neuron. Elsevier, 2016. https://doi.org/10.1016/j.neuron.2016.02.031.","ista":"Barron HC, Vogels TP, Emir UE, Makin TR, O’Shea J, Clare S, Jbabdi S, Dolan RJ, Behrens TEJ. 2016. Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories. Neuron. 90(1), 191–203."},"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","author":[{"last_name":"Barron","full_name":"Barron, H.C.","first_name":"H.C."},{"last_name":"Vogels","full_name":"Vogels, Tim P","orcid":"0000-0003-3295-6181","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","first_name":"Tim P"},{"first_name":"U.E.","full_name":"Emir, U.E.","last_name":"Emir"},{"first_name":"T.R.","full_name":"Makin, T.R.","last_name":"Makin"},{"last_name":"O’Shea","full_name":"O’Shea, J.","first_name":"J."},{"first_name":"S.","full_name":"Clare, S.","last_name":"Clare"},{"full_name":"Jbabdi, S.","last_name":"Jbabdi","first_name":"S."},{"full_name":"Dolan, R.J.","last_name":"Dolan","first_name":"R.J."},{"full_name":"Behrens, T.E.J.","last_name":"Behrens","first_name":"T.E.J."}],"external_id":{"pmid":["26996082"]},"article_processing_charge":"No","title":"Unmasking latent inhibitory connections in human cortex to reveal dormant cortical memories"},{"_id":"8022","type":"journal_article","article_type":"original","status":"public","date_updated":"2021-01-12T08:16:35Z","extern":"1","abstract":[{"text":"Populations of neurons in motor cortex engage in complex transient dynamics of large amplitude during the execution of limb movements. Traditional network models with stochastically assigned synapses cannot reproduce this behavior. Here we introduce a class of cortical architectures with strong and random excitatory recurrence that is stabilized by intricate, fine-tuned inhibition, optimized from a control theory perspective. Such networks transiently amplify specific activity states and can be used to reliably execute multidimensional movement patterns. Similar to the experimental observations, these transients must be preceded by a steady-state initialization phase from which the network relaxes back into the background state by way of complex internal dynamics. In our networks, excitation and inhibition are as tightly balanced as recently reported in experiments across several brain areas, suggesting inhibitory control of complex excitatory recurrence as a generic organizational principle in cortex.","lang":"eng"}],"oa_version":"Submitted Version","pmid":1,"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6364799/"}],"month":"06","intvolume":" 82","publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","language":[{"iso":"eng"}],"volume":82,"issue":"6","citation":{"apa":"Hennequin, G., Vogels, T. P., & Gerstner, W. (2014). Optimal control of transient dynamics in balanced networks supports generation of complex movements. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2014.04.045","ama":"Hennequin G, Vogels TP, Gerstner W. Optimal control of transient dynamics in balanced networks supports generation of complex movements. Neuron. 2014;82(6):1394-1406. doi:10.1016/j.neuron.2014.04.045","short":"G. Hennequin, T.P. Vogels, W. Gerstner, Neuron 82 (2014) 1394–1406.","ieee":"G. Hennequin, T. P. Vogels, and W. Gerstner, “Optimal control of transient dynamics in balanced networks supports generation of complex movements,” Neuron, vol. 82, no. 6. Elsevier, pp. 1394–1406, 2014.","mla":"Hennequin, Guillaume, et al. “Optimal Control of Transient Dynamics in Balanced Networks Supports Generation of Complex Movements.” Neuron, vol. 82, no. 6, Elsevier, 2014, pp. 1394–406, doi:10.1016/j.neuron.2014.04.045.","ista":"Hennequin G, Vogels TP, Gerstner W. 2014. Optimal control of transient dynamics in balanced networks supports generation of complex movements. Neuron. 82(6), 1394–1406.","chicago":"Hennequin, Guillaume, Tim P Vogels, and Wulfram Gerstner. “Optimal Control of Transient Dynamics in Balanced Networks Supports Generation of Complex Movements.” Neuron. Elsevier, 2014. https://doi.org/10.1016/j.neuron.2014.04.045."},"user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","author":[{"full_name":"Hennequin, Guillaume","last_name":"Hennequin","first_name":"Guillaume"},{"id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","first_name":"Tim P","last_name":"Vogels","full_name":"Vogels, Tim P","orcid":"0000-0003-3295-6181"},{"first_name":"Wulfram","full_name":"Gerstner, Wulfram","last_name":"Gerstner"}],"external_id":{"pmid":["24945778"]},"article_processing_charge":"No","title":"Optimal control of transient dynamics in balanced networks supports generation of complex movements","quality_controlled":"1","publisher":"Elsevier","oa":1,"year":"2014","day":"18","publication":"Neuron","page":"1394-1406","doi":"10.1016/j.neuron.2014.04.045","date_published":"2014-06-18T00:00:00Z","date_created":"2020-06-25T13:07:37Z"},{"article_type":"original","type":"journal_article","status":"public","_id":"7785","article_processing_charge":"No","author":[{"first_name":"William J.","last_name":"Joo","full_name":"Joo, William J."},{"orcid":"0000-0001-9242-5601","full_name":"Sweeney, Lora Beatrice Jaeger","last_name":"Sweeney","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","first_name":"Lora Beatrice Jaeger"},{"first_name":"Liang","full_name":"Liang, Liang","last_name":"Liang"},{"first_name":"Liqun","full_name":"Luo, Liqun","last_name":"Luo"}],"title":"Linking cell fate, trajectory choice, and target selection: Genetic analysis of sema-2b in olfactory axon targeting","citation":{"mla":"Joo, William J., et al. “Linking Cell Fate, Trajectory Choice, and Target Selection: Genetic Analysis of Sema-2b in Olfactory Axon Targeting.” Neuron, vol. 78, no. 4, Elsevier, 2013, pp. 673–86, doi:10.1016/j.neuron.2013.03.022.","short":"W.J. Joo, L.B. Sweeney, L. Liang, L. Luo, Neuron 78 (2013) 673–686.","ieee":"W. J. Joo, L. B. Sweeney, L. Liang, and L. Luo, “Linking cell fate, trajectory choice, and target selection: Genetic analysis of sema-2b in olfactory axon targeting,” Neuron, vol. 78, no. 4. Elsevier, pp. 673–686, 2013.","apa":"Joo, W. J., Sweeney, L. B., Liang, L., & Luo, L. (2013). Linking cell fate, trajectory choice, and target selection: Genetic analysis of sema-2b in olfactory axon targeting. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2013.03.022","ama":"Joo WJ, Sweeney LB, Liang L, Luo L. Linking cell fate, trajectory choice, and target selection: Genetic analysis of sema-2b in olfactory axon targeting. Neuron. 2013;78(4):673-686. doi:10.1016/j.neuron.2013.03.022","chicago":"Joo, William J., Lora B. Sweeney, Liang Liang, and Liqun Luo. “Linking Cell Fate, Trajectory Choice, and Target Selection: Genetic Analysis of Sema-2b in Olfactory Axon Targeting.” Neuron. Elsevier, 2013. https://doi.org/10.1016/j.neuron.2013.03.022.","ista":"Joo WJ, Sweeney LB, Liang L, Luo L. 2013. Linking cell fate, trajectory choice, and target selection: Genetic analysis of sema-2b in olfactory axon targeting. Neuron. 78(4), 673–686."},"date_updated":"2024-01-31T10:15:25Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","quality_controlled":"1","publisher":"Elsevier","intvolume":" 78","month":"05","abstract":[{"lang":"eng","text":"Neural circuit assembly requires selection of specific cell fates, axonal trajectories, and synaptic targets. By analyzing the function of a secreted semaphorin, Sema-2b, in Drosophila olfactory receptor neuron (ORN) development, we identified multiple molecular and cellular mechanisms that link these events. Notch signaling limits Sema-2b expression to ventromedial ORN classes, within which Sema-2b cell-autonomously sensitizes ORN axons to external semaphorins. Central-brain-derived Sema-2a and Sema-2b attract Sema-2b-expressing axons to the ventromedial trajectory. In addition, Sema-2b/PlexB-mediated axon-axon interactions consolidate this trajectory choice and promote ventromedial axon-bundle formation. Selecting the correct developmental trajectory is ultimately essential for proper target choice. These findings demonstrate that Sema-2b couples ORN axon guidance to postsynaptic target neuron dendrite patterning well before the final target selection phase, and exemplify how a single guidance molecule can drive consecutive stages of neural circuit assembly with the help of sophisticated spatial and temporal regulation."}],"oa_version":"None","page":"673-686","date_created":"2020-04-30T13:19:59Z","doi":"10.1016/j.neuron.2013.03.022","date_published":"2013-05-22T00:00:00Z","issue":"4","volume":78,"publication_status":"published","year":"2013","publication_identifier":{"issn":["0896-6273"]},"publication":"Neuron","language":[{"iso":"eng"}],"day":"22"},{"title":"Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior","author":[{"last_name":"Bretscher","full_name":"Bretscher, Andrew Jonathan","first_name":"Andrew Jonathan"},{"first_name":"Eiji","last_name":"Kodama-Namba","full_name":"Kodama-Namba, Eiji"},{"first_name":"Karl Emanuel","last_name":"Busch","full_name":"Busch, Karl Emanuel"},{"full_name":"Murphy, Robin Joseph","last_name":"Murphy","first_name":"Robin Joseph"},{"full_name":"Soltesz, Zoltan","last_name":"Soltesz","first_name":"Zoltan"},{"last_name":"Laurent","full_name":"Laurent, Patrick","first_name":"Patrick"},{"id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","first_name":"Mario","last_name":"de Bono","orcid":"0000-0001-8347-0443","full_name":"de Bono, Mario"}],"external_id":{"pmid":["21435556"]},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"apa":"Bretscher, A. J., Kodama-Namba, E., Busch, K. E., Murphy, R. J., Soltesz, Z., Laurent, P., & de Bono, M. (2011). Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron. Elsevier BV. https://doi.org/10.1016/j.neuron.2011.02.023","ama":"Bretscher AJ, Kodama-Namba E, Busch KE, et al. Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron. 2011;69(6):1099-1113. doi:10.1016/j.neuron.2011.02.023","short":"A.J. Bretscher, E. Kodama-Namba, K.E. Busch, R.J. Murphy, Z. Soltesz, P. Laurent, M. de Bono, Neuron 69 (2011) 1099–1113.","ieee":"A. J. Bretscher et al., “Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior,” Neuron, vol. 69, no. 6. Elsevier BV, pp. 1099–1113, 2011.","mla":"Bretscher, Andrew Jonathan, et al. “Temperature, Oxygen, and Salt-Sensing Neurons in C. Elegans Are Carbon Dioxide Sensors That Control Avoidance Behavior.” Neuron, vol. 69, no. 6, Elsevier BV, 2011, pp. 1099–113, doi:10.1016/j.neuron.2011.02.023.","ista":"Bretscher AJ, Kodama-Namba E, Busch KE, Murphy RJ, Soltesz Z, Laurent P, de Bono M. 2011. Temperature, oxygen, and salt-sensing neurons in C. elegans are carbon dioxide sensors that control avoidance behavior. Neuron. 69(6), 1099–1113.","chicago":"Bretscher, Andrew Jonathan, Eiji Kodama-Namba, Karl Emanuel Busch, Robin Joseph Murphy, Zoltan Soltesz, Patrick Laurent, and Mario de Bono. “Temperature, Oxygen, and Salt-Sensing Neurons in C. Elegans Are Carbon Dioxide Sensors That Control Avoidance Behavior.” Neuron. Elsevier BV, 2011. https://doi.org/10.1016/j.neuron.2011.02.023."},"date_published":"2011-03-24T00:00:00Z","doi":"10.1016/j.neuron.2011.02.023","date_created":"2019-03-20T15:01:41Z","page":"1099-1113","day":"24","publication":"Neuron","has_accepted_license":"1","year":"2011","publisher":"Elsevier BV","quality_controlled":"1","oa":1,"file_date_updated":"2020-07-14T12:47:20Z","extern":"1","ddc":["570"],"date_updated":"2021-01-12T08:06:18Z","status":"public","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"_id":"6138","volume":69,"issue":"6","file":[{"creator":"kschuh","date_updated":"2020-07-14T12:47:20Z","file_size":2448332,"date_created":"2019-03-20T15:06:32Z","file_name":"2011_Cell_Bretscher.pdf","access_level":"open_access","relation":"main_file","content_type":"application/pdf","checksum":"547cffd123f4c508ae927c9244b8f92a","file_id":"6139"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","month":"03","intvolume":" 69","pmid":1,"oa_version":"Published Version"},{"page":"734-747","doi":"10.1016/j.neuron.2011.09.026","volume":72,"date_published":"2011-12-08T00:00:00Z","issue":"5","date_created":"2020-04-30T10:36:12Z","publication_identifier":{"issn":["0896-6273"]},"year":"2011","publication_status":"published","day":"08","language":[{"iso":"eng"}],"publication":"Neuron","publisher":"Elsevier","quality_controlled":"1","month":"12","intvolume":" 72","abstract":[{"lang":"eng","text":"During assembly of the Drosophila olfactory circuit, projection neuron (PN) dendrites prepattern the developing antennal lobe before the arrival of axons from their presynaptic partners, the adult olfactory receptor neurons (ORNs). We previously found that levels of transmembrane Semaphorin-1a, which acts as a receptor, instruct PN dendrite targeting along the dorsolateral-ventromedial axis. Here we show that two secreted semaphorins, Sema-2a and Sema-2b, provide spatial cues for PN dendrite targeting. Sema-2a and Sema-2b proteins are distributed in gradients opposing the Sema-1a protein gradient, and Sema-1a binds to Sema-2a-expressing cells. In Sema-2a and Sema-2b double mutants, PN dendrites that normally target dorsolaterally in the antennal lobe mistarget ventromedially, phenocopying cell-autonomous Sema-1a removal from these PNs. Cell ablation, cell-specific knockdown, and rescue experiments indicate that secreted semaphorins from degenerating larval ORN axons direct dendrite targeting. Thus, a degenerating brain structure instructs the wiring of a developing circuit through the repulsive action of secreted semaphorins."}],"oa_version":"None","author":[{"first_name":"Lora Beatrice Jaeger","id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","last_name":"Sweeney","full_name":"Sweeney, Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601"},{"last_name":"Chou","full_name":"Chou, Ya-Hui","first_name":"Ya-Hui"},{"first_name":"Zhuhao","last_name":"Wu","full_name":"Wu, Zhuhao"},{"first_name":"William","full_name":"Joo, William","last_name":"Joo"},{"last_name":"Komiyama","full_name":"Komiyama, Takaki","first_name":"Takaki"},{"first_name":"Christopher J.","last_name":"Potter","full_name":"Potter, Christopher J."},{"last_name":"Kolodkin","full_name":"Kolodkin, Alex L.","first_name":"Alex L."},{"last_name":"Garcia","full_name":"Garcia, K. Christopher","first_name":"K. Christopher"},{"first_name":"Liqun","last_name":"Luo","full_name":"Luo, Liqun"}],"article_processing_charge":"No","title":"Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting","date_updated":"2024-01-31T10:13:39Z","citation":{"mla":"Sweeney, Lora B., et al. “Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection Neuron Dendrite Targeting.” Neuron, vol. 72, no. 5, Elsevier, 2011, pp. 734–47, doi:10.1016/j.neuron.2011.09.026.","apa":"Sweeney, L. B., Chou, Y.-H., Wu, Z., Joo, W., Komiyama, T., Potter, C. J., … Luo, L. (2011). Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2011.09.026","ama":"Sweeney LB, Chou Y-H, Wu Z, et al. Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron. 2011;72(5):734-747. doi:10.1016/j.neuron.2011.09.026","ieee":"L. B. Sweeney et al., “Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting,” Neuron, vol. 72, no. 5. Elsevier, pp. 734–747, 2011.","short":"L.B. Sweeney, Y.-H. Chou, Z. Wu, W. Joo, T. Komiyama, C.J. Potter, A.L. Kolodkin, K.C. Garcia, L. Luo, Neuron 72 (2011) 734–747.","chicago":"Sweeney, Lora B., Ya-Hui Chou, Zhuhao Wu, William Joo, Takaki Komiyama, Christopher J. Potter, Alex L. Kolodkin, K. Christopher Garcia, and Liqun Luo. “Secreted Semaphorins from Degenerating Larval ORN Axons Direct Adult Projection Neuron Dendrite Targeting.” Neuron. Elsevier, 2011. https://doi.org/10.1016/j.neuron.2011.09.026.","ista":"Sweeney LB, Chou Y-H, Wu Z, Joo W, Komiyama T, Potter CJ, Kolodkin AL, Garcia KC, Luo L. 2011. Secreted semaphorins from degenerating larval ORN axons direct adult projection neuron dendrite targeting. Neuron. 72(5), 734–747."},"extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","type":"journal_article","status":"public","_id":"7701"},{"citation":{"mla":"Wu, Zhuhao, et al. “A Combinatorial Semaphorin Code Instructs the Initial Steps of Sensory Circuit Assembly in the Drosophila CNS.” Neuron, vol. 70, no. 2, Elsevier, 2011, pp. 281–98, doi:10.1016/j.neuron.2011.02.050.","apa":"Wu, Z., Sweeney, L. B., Ayoob, J. C., Chak, K., Andreone, B. J., Ohyama, T., … Kolodkin, A. L. (2011). A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2011.02.050","ama":"Wu Z, Sweeney LB, Ayoob JC, et al. A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron. 2011;70(2):281-298. doi:10.1016/j.neuron.2011.02.050","short":"Z. Wu, L.B. Sweeney, J.C. Ayoob, K. Chak, B.J. Andreone, T. Ohyama, R. Kerr, L. Luo, M. Zlatic, A.L. Kolodkin, Neuron 70 (2011) 281–298.","ieee":"Z. Wu et al., “A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS,” Neuron, vol. 70, no. 2. Elsevier, pp. 281–298, 2011.","chicago":"Wu, Zhuhao, Lora B. Sweeney, Joseph C. Ayoob, Kayam Chak, Benjamin J. Andreone, Tomoko Ohyama, Rex Kerr, Liqun Luo, Marta Zlatic, and Alex L. Kolodkin. “A Combinatorial Semaphorin Code Instructs the Initial Steps of Sensory Circuit Assembly in the Drosophila CNS.” Neuron. Elsevier, 2011. https://doi.org/10.1016/j.neuron.2011.02.050.","ista":"Wu Z, Sweeney LB, Ayoob JC, Chak K, Andreone BJ, Ohyama T, Kerr R, Luo L, Zlatic M, Kolodkin AL. 2011. A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS. Neuron. 70(2), 281–298."},"date_updated":"2024-01-31T10:14:29Z","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Zhuhao","last_name":"Wu","full_name":"Wu, Zhuhao"},{"id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","first_name":"Lora Beatrice Jaeger","last_name":"Sweeney","full_name":"Sweeney, Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601"},{"last_name":"Ayoob","full_name":"Ayoob, Joseph C.","first_name":"Joseph C."},{"first_name":"Kayam","last_name":"Chak","full_name":"Chak, Kayam"},{"full_name":"Andreone, Benjamin J.","last_name":"Andreone","first_name":"Benjamin J."},{"full_name":"Ohyama, Tomoko","last_name":"Ohyama","first_name":"Tomoko"},{"full_name":"Kerr, Rex","last_name":"Kerr","first_name":"Rex"},{"first_name":"Liqun","last_name":"Luo","full_name":"Luo, Liqun"},{"first_name":"Marta","last_name":"Zlatic","full_name":"Zlatic, Marta"},{"full_name":"Kolodkin, Alex L.","last_name":"Kolodkin","first_name":"Alex L."}],"article_processing_charge":"No","title":"A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS","_id":"7702","type":"journal_article","article_type":"original","status":"public","publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","year":"2011","day":"28","publication":"Neuron","language":[{"iso":"eng"}],"page":"281-298","doi":"10.1016/j.neuron.2011.02.050","date_published":"2011-04-28T00:00:00Z","issue":"2","volume":70,"date_created":"2020-04-30T10:36:30Z","abstract":[{"text":"Longitudinal axon fascicles within the Drosophila embryonic CNS provide connections between body segments and are required for coordinated neural signaling along the anterior-posterior axis. We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (PlexB), but serve distinct guidance functions. Localized Sema-2b attraction promotes the initial assembly of a subset of CNS longitudinal projections and subsequent targeting of chordotonal sensory afferent axons to these same longitudinal connectives, whereas broader Sema-2a repulsion serves to prevent aberrant innervation. In the absence of Sema-2b or PlexB, chordotonal afferent connectivity within the CNS is severely disrupted, resulting in specific larval behavioral deficits. These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly.","lang":"eng"}],"oa_version":"None","publisher":"Elsevier","quality_controlled":"1","month":"04","intvolume":" 70"},{"day":"18","language":[{"iso":"eng"}],"publication":"Neuron","publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","year":"2007","issue":"2","date_published":"2007-01-18T00:00:00Z","volume":53,"doi":"10.1016/j.neuron.2006.12.022","date_created":"2020-04-30T10:37:24Z","page":"185-200","oa_version":"None","abstract":[{"text":"Axon-axon interactions have been implicated in neural circuit assembly, but the underlying mechanisms are poorly understood. Here, we show that in the Drosophila antennal lobe, early-arriving axons of olfactory receptor neurons (ORNs) from the antenna are required for the proper targeting of late-arriving ORN axons from the maxillary palp (MP). Semaphorin-1a is required for targeting of all MP but only half of the antennal ORN classes examined. Sema-1a acts nonautonomously to control ORN axon-axon interactions, in contrast to its cell-autonomous function in olfactory projection neurons. Phenotypic and genetic interaction analyses implicate PlexinA as the Sema-1a receptor in ORN targeting. Sema-1a on antennal ORN axons is required for correct targeting of MP axons within the antennal lobe, while interactions amongst MP axons facilitate their entry into the antennal lobe. We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons.","lang":"eng"}],"month":"01","intvolume":" 53","publisher":"Elsevier","quality_controlled":"1","extern":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2024-01-31T10:14:39Z","citation":{"chicago":"Sweeney, Lora B., Africa Couto, Ya-Hui Chou, Daniela Berdnik, Barry J. Dickson, Liqun Luo, and Takaki Komiyama. “Temporal Target Restriction of Olfactory Receptor Neurons by Semaphorin-1a/PlexinA-Mediated Axon-Axon Interactions.” Neuron. Elsevier, 2007. https://doi.org/10.1016/j.neuron.2006.12.022.","ista":"Sweeney LB, Couto A, Chou Y-H, Berdnik D, Dickson BJ, Luo L, Komiyama T. 2007. Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions. Neuron. 53(2), 185–200.","mla":"Sweeney, Lora B., et al. “Temporal Target Restriction of Olfactory Receptor Neurons by Semaphorin-1a/PlexinA-Mediated Axon-Axon Interactions.” Neuron, vol. 53, no. 2, Elsevier, 2007, pp. 185–200, doi:10.1016/j.neuron.2006.12.022.","ama":"Sweeney LB, Couto A, Chou Y-H, et al. Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions. Neuron. 2007;53(2):185-200. doi:10.1016/j.neuron.2006.12.022","apa":"Sweeney, L. B., Couto, A., Chou, Y.-H., Berdnik, D., Dickson, B. J., Luo, L., & Komiyama, T. (2007). Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2006.12.022","short":"L.B. Sweeney, A. Couto, Y.-H. Chou, D. Berdnik, B.J. Dickson, L. Luo, T. Komiyama, Neuron 53 (2007) 185–200.","ieee":"L. B. Sweeney et al., “Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions,” Neuron, vol. 53, no. 2. Elsevier, pp. 185–200, 2007."},"title":"Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions","author":[{"id":"56BE8254-C4F0-11E9-8E45-0B23E6697425","first_name":"Lora Beatrice Jaeger","orcid":"0000-0001-9242-5601","full_name":"Sweeney, Lora Beatrice Jaeger","last_name":"Sweeney"},{"first_name":"Africa","last_name":"Couto","full_name":"Couto, Africa"},{"full_name":"Chou, Ya-Hui","last_name":"Chou","first_name":"Ya-Hui"},{"full_name":"Berdnik, Daniela","last_name":"Berdnik","first_name":"Daniela"},{"first_name":"Barry J.","full_name":"Dickson, Barry J.","last_name":"Dickson"},{"last_name":"Luo","full_name":"Luo, Liqun","first_name":"Liqun"},{"last_name":"Komiyama","full_name":"Komiyama, Takaki","first_name":"Takaki"}],"article_processing_charge":"No","_id":"7705","status":"public","article_type":"original","type":"journal_article"},{"_id":"4194","article_type":"original","type":"journal_article","status":"public","date_updated":"2023-06-07T09:43:19Z","extern":"1","abstract":[{"text":"Cells at the anterior boundary of the neural plate (ANB) can induce telencephalic gene expression when transplanted to more posterior regions. Here, we identify a secreted Frizzled-related Wnt antagonist, Tic, that is expressed in ANB cells and can cell nonautonomously promote telencephalic gene expression in a concentration-dependent manner. Moreover, abrogation of Tlc function compromises telencephalic development. We also identify Wnt8b as a locally acting modulator of regional fate in the anterior neural plate and a likely target for antagonism by Tic. Finally, we show that tlc expression is regulated by signals that establish early antero-posterior and dorso-ventral ectodermal pattern. From these studies, we propose that local antagonism of Wnt activity within the anterior ectoderm is required to establish the telencephalon.","lang":"eng"}],"oa_version":"None","pmid":1,"scopus_import":"1","intvolume":" 35","month":"07","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"volume":35,"issue":"2","citation":{"chicago":"Houart, Corinne, Luca Caneparo, Carl-Philipp J Heisenberg, K Anukampa Barth, Masaya Take Uchi, and Stephen Wilson. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” Neuron. Elsevier, 2002. https://doi.org/10.1016/S0896-6273(02)00751-1.","ista":"Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. 2002. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 35(2), 255–265.","mla":"Houart, Corinne, et al. “Establishment of the Telencephalon during Gastrulation by Local Antagonism of Wnt Signaling.” Neuron, vol. 35, no. 2, Elsevier, 2002, pp. 255–65, doi:10.1016/S0896-6273(02)00751-1.","short":"C. Houart, L. Caneparo, C.-P.J. Heisenberg, K.A. Barth, M. Take Uchi, S. Wilson, Neuron 35 (2002) 255–265.","ieee":"C. Houart, L. Caneparo, C.-P. J. Heisenberg, K. A. Barth, M. Take Uchi, and S. Wilson, “Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling,” Neuron, vol. 35, no. 2. Elsevier, pp. 255–265, 2002.","ama":"Houart C, Caneparo L, Heisenberg C-PJ, Barth KA, Take Uchi M, Wilson S. Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. 2002;35(2):255-265. doi:10.1016/S0896-6273(02)00751-1","apa":"Houart, C., Caneparo, L., Heisenberg, C.-P. J., Barth, K. A., Take Uchi, M., & Wilson, S. (2002). Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)00751-1"},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["12160744"]},"publist_id":"1925","author":[{"last_name":"Houart","full_name":"Houart, Corinne","first_name":"Corinne"},{"last_name":"Caneparo","full_name":"Caneparo, Luca","first_name":"Luca"},{"last_name":"Heisenberg","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J"},{"full_name":"Barth, K Anukampa","last_name":"Barth","first_name":"K Anukampa"},{"first_name":"Masaya","full_name":"Take Uchi, Masaya","last_name":"Take Uchi"},{"full_name":"Wilson, Stephen","last_name":"Wilson","first_name":"Stephen"}],"title":"Establishment of the telencephalon during gastrulation by local antagonism of Wnt signaling","acknowledgement":"We thank many of our colleagues, especially Randy Moon, for providing reagents used in this study. This study was supported by the Wellcome Trust, MRC, and BBSRC to S.W.W. and C.H. S.W.W. is a Wellcome Trust Senior Research Fellow.","publisher":"Elsevier","quality_controlled":"1","year":"2002","publication":"Neuron","day":"18","page":"255 - 265","date_created":"2018-12-11T12:07:30Z","date_published":"2002-07-18T00:00:00Z","doi":"10.1016/S0896-6273(02)00751-1"},{"date_updated":"2023-07-17T11:46:43Z","extern":"1","_id":"3140","article_type":"original","type":"journal_article","status":"public","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"volume":36,"issue":"6","abstract":[{"lang":"eng","text":"The maturation of synaptic structures depends on inductive interactions between axons and their prospective targets. One example of such an interaction is the influence of proprioceptive sensory axons on the differentiation of muscle spindles. We have monitored the expression of three transcription factors, Egr3, Pea3, and Erm, that delineate early muscle spindle development in an assay of muscle spindle-inducing signals. We provide genetic evidence that Neuregulin1 (Nrg1) is required for proprioceptive afferent-evoked induction of muscle spindle differentiation in the mouse. Ig-Nrg1 isoforms are preferentially expressed by proprioceptive sensory neurons and are sufficient to induce muscle spindle differentiation in vivo, whereas CRD-Nrg1 isoforms are broadly expressed in sensory and motor neurons but are not required for muscle spindle induction."}],"pmid":1,"oa_version":"None","scopus_import":"1","intvolume":" 36","month":"12","citation":{"ista":"Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. 2002. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 36(6), 1035–1049.","chicago":"Hippenmeyer, Simon, Neil Shneider, Carmen Birchmeier, Steven Burden, Thomas Jessell, and Silvia Arber. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” Neuron. Elsevier, 2002. https://doi.org/10.1016/S0896-6273(02)01101-7.","short":"S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, S. Arber, Neuron 36 (2002) 1035–1049.","ieee":"S. Hippenmeyer, N. Shneider, C. Birchmeier, S. Burden, T. Jessell, and S. Arber, “A role for Neuregulin1 signaling in muscle spindle differentiation,” Neuron, vol. 36, no. 6. Elsevier, pp. 1035–1049, 2002.","ama":"Hippenmeyer S, Shneider N, Birchmeier C, Burden S, Jessell T, Arber S. A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. 2002;36(6):1035-1049. doi:10.1016/S0896-6273(02)01101-7","apa":"Hippenmeyer, S., Shneider, N., Birchmeier, C., Burden, S., Jessell, T., & Arber, S. (2002). A role for Neuregulin1 signaling in muscle spindle differentiation. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(02)01101-7","mla":"Hippenmeyer, Simon, et al. “A Role for Neuregulin1 Signaling in Muscle Spindle Differentiation.” Neuron, vol. 36, no. 6, Elsevier, 2002, pp. 1035–49, doi:10.1016/S0896-6273(02)01101-7."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["12495620"]},"author":[{"last_name":"Hippenmeyer","orcid":"0000-0003-2279-1061","full_name":"Hippenmeyer, Simon","id":"37B36620-F248-11E8-B48F-1D18A9856A87","first_name":"Simon"},{"full_name":"Shneider, Neil","last_name":"Shneider","first_name":"Neil"},{"full_name":"Birchmeier, Carmen","last_name":"Birchmeier","first_name":"Carmen"},{"first_name":"Steven","full_name":"Burden, Steven","last_name":"Burden"},{"first_name":"Thomas","last_name":"Jessell","full_name":"Jessell, Thomas"},{"full_name":"Arber, Silvia","last_name":"Arber","first_name":"Silvia"}],"publist_id":"3558","title":"A role for Neuregulin1 signaling in muscle spindle differentiation","year":"2002","publication":"Neuron","day":"19","page":"1035 - 1049","date_created":"2018-12-11T12:01:37Z","doi":"10.1016/S0896-6273(02)01101-7","date_published":"2002-12-19T00:00:00Z","acknowledgement":"We thank L. Role for generously providing the CRD-Nrg1 mutant allele for these studies, L. Parada and D. Anderson for sharing the TrkC and Ngn1 mouse strains, W. Tourtellotte for providing Egr3 mutant mice, E. Avetisova for expert technical assistance, X. Yang for experimental help in the initial phase of these studies, A. Garratt for advice with ErbB antibodies, and L. Role and G. Fischbach for helpful discussions. The CRD-Nrg1 mutant allele was generated in the lab of Dr. Lorna Role, with the support of NIH grant NS29071. S.A. and S.H. were supported by a grant from the Swiss National Science Foundation and the Kanton of Basel-Stadt. S.J.B. was supported by grants from the NINDS. N.A.S. was supported by a Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians and a Career Development Award from the NINDS. T.M.J. was supported by grants from NINDS and is an Investigator of the Howard Hughes Medical Institute.","publisher":"Elsevier","quality_controlled":"1"},{"_id":"3492","type":"journal_article","article_type":"original","status":"public","date_updated":"2023-05-02T14:34:37Z","extern":"1","abstract":[{"lang":"eng","text":"Analysis of presynaptic determinants of synaptic strength has been difficult at cortical synapses, mainly due to the lack of direct access to presynaptic elements. Here we report patch-clamp recordings from mossy fiber boutons (MFBs) in rat hippocampal slices. The presynaptic action potential is very short during low-frequency stimulation but is prolonged up to 3-fold during high-frequency stimulation. Voltage-gated K+ channels in MFBs inactivate rapidly but recover from inactivation very slowly, suggesting that cumulative K+ channel inactivation mediates activity-dependent spike broadening. Prolongation of the presynaptic voltage waveform leads to an increase in the number of Ca2+ ions entering the terminal per action potential and to a consecutive potentiation of evoked excitatory postsynaptic currents at MFB-CA3 pyramidal cell synapses. Thus, inactivation of presynaptic K+ channels contributes to the control of efficacy of a glutamatergic synapse in the cortex."}],"oa_version":"None","pmid":1,"intvolume":" 28","month":"12","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"volume":28,"issue":"3","citation":{"apa":"Geiger, J., & Jonas, P. M. (2000). Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00164-1","ama":"Geiger J, Jonas PM. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 2000;28(3):927-939. doi:10.1016/S0896-6273(00)00164-1","ieee":"J. Geiger and P. M. Jonas, “Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons,” Neuron, vol. 28, no. 3. Elsevier, pp. 927–939, 2000.","short":"J. Geiger, P.M. Jonas, Neuron 28 (2000) 927–939.","mla":"Geiger, Jörg, and Peter M. Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron, vol. 28, no. 3, Elsevier, 2000, pp. 927–39, doi:10.1016/S0896-6273(00)00164-1.","ista":"Geiger J, Jonas PM. 2000. Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons. Neuron. 28(3), 927–939.","chicago":"Geiger, Jörg, and Peter M Jonas. “Dynamic Control of Presynaptic Ca(2+) Inflow by Fast-Inactivating K+ Channels in Hippocampal Mossy Fiber Boutons.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00164-1."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["11163277"]},"author":[{"full_name":"Geiger, Jörg","last_name":"Geiger","first_name":"Jörg"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas"}],"publist_id":"2895","title":"Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K+ channels in hippocampal mossy fiber boutons","quality_controlled":"1","publisher":"Elsevier","year":"2000","publication":"Neuron","day":"01","page":"927 - 939","date_created":"2018-12-11T12:03:37Z","date_published":"2000-12-01T00:00:00Z","doi":"10.1016/S0896-6273(00)00164-1"},{"month":"11","intvolume":" 28","quality_controlled":"1","publisher":"Elsevier","oa_version":"None","abstract":[{"text":"Transfer of neuronal patterns from the CA3 to CA1 region was studied by simultaneous recording of neuronal ensembles in the behaving rat. A nonlinear interaction among pyramidal neurons was observed during sharp wave (SPW)-related population bursts, with stronger synchrony associated with more widespread spatial coherence. SPW bursts emerged in the CA3a-b subregions and spread to CA3c before invading the CA1 area. Synchronous discharge of >10% of the CA3 within a 100 ms window was required to exert a detectable influence on CA1 pyramidal cells. Activity of some CA3 pyramidal neurons differentially predicted the ripple-related discharge of circumscribed groups of CA1 pyramidal cells. We suggest that, in SPW behavioral state, the coherent discharge of a small group of CA3 cells is the primary cause of spiking activity in CA1 pyramidal neurons.","lang":"eng"}],"doi":"10.1016/S0896-6273(00)00135-5","volume":28,"issue":"2","date_published":"2000-11-01T00:00:00Z","date_created":"2018-12-11T12:03:52Z","page":"585 - 594","day":"01","language":[{"iso":"eng"}],"publication":"Neuron","publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","year":"2000","status":"public","type":"journal_article","article_type":"original","_id":"3542","title":"Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events","publist_id":"2843","author":[{"last_name":"Csicsvari","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","first_name":"Jozsef L","id":"3FA14672-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Hajima","last_name":"Hirase","full_name":"Hirase, Hajima"},{"full_name":"Mamiya, Akira","last_name":"Mamiya","first_name":"Akira"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"}],"article_processing_charge":"No","extern":"1","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2023-05-02T14:26:07Z","citation":{"apa":"Csicsvari, J. L., Hirase, H., Mamiya, A., & Buzsáki, G. (2000). Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00135-5","ama":"Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. 2000;28(2):585-594. doi:10.1016/S0896-6273(00)00135-5","short":"J.L. Csicsvari, H. Hirase, A. Mamiya, G. Buzsáki, Neuron 28 (2000) 585–594.","ieee":"J. L. Csicsvari, H. Hirase, A. Mamiya, and G. Buzsáki, “Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events,” Neuron, vol. 28, no. 2. Elsevier, pp. 585–594, 2000.","mla":"Csicsvari, Jozsef L., et al. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population Events.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 585–94, doi:10.1016/S0896-6273(00)00135-5.","ista":"Csicsvari JL, Hirase H, Mamiya A, Buzsáki G. 2000. Ensemble patterns of hippocampal CA3-CA1 neurons during sharp wave-associated population events. Neuron. 28(2), 585–594.","chicago":"Csicsvari, Jozsef L, Hajima Hirase, Akira Mamiya, and György Buzsáki. “Ensemble Patterns of Hippocampal CA3-CA1 Neurons during Sharp Wave-Associated Population Events.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00135-5."}},{"quality_controlled":"1","publisher":"Elsevier","acknowledgement":"We thank Drs. S. Nakanishi, K. Moriyoshi, V. I. Gelfand, and P. J. Conn for gifts of cDNAs and antibodies, A. S. Serpinskaya and H. Wu for excellent preparation of neuron cultures, and H. J. Chung for help in immunoblots. This work was supported by the Pew Chari-table Trust and National Institutes of Health grants NS33184 and NS39286 (A. M. C.), K02MH01152 and NIDA DA10309 (P. W.), and a fellowship from IPSEN Foundation (H. B.). ","date_created":"2018-12-11T11:58:37Z","doi":"10.1016/S0896-6273(00)00127-6","date_published":"2000-11-01T00:00:00Z","page":"485 - 497","publication":"Neuron","day":"01","year":"2000","title":"Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site","external_id":{"pmid":["11144358"]},"article_processing_charge":"No","author":[{"last_name":"Boudin","full_name":"Boudin, Hélène","first_name":"Hélène"},{"first_name":"Andrew","last_name":"Doan","full_name":"Doan, Andrew"},{"first_name":"Jun","last_name":"Xia","full_name":"Xia, Jun"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","last_name":"Shigemoto"},{"full_name":"Huganir, Richard","last_name":"Huganir","first_name":"Richard"},{"first_name":"Paul","last_name":"Worley","full_name":"Worley, Paul"},{"first_name":"Ann","full_name":"Craig, Ann","last_name":"Craig"}],"publist_id":"4295","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Boudin, Hélène, Andrew Doan, Jun Xia, Ryuichi Shigemoto, Richard Huganir, Paul Worley, and Ann Craig. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron. Elsevier, 2000. https://doi.org/10.1016/S0896-6273(00)00127-6.","ista":"Boudin H, Doan A, Xia J, Shigemoto R, Huganir R, Worley P, Craig A. 2000. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 28(2), 485–497.","mla":"Boudin, Hélène, et al. “Presynaptic Clustering of MGluR7a Requires the PICK1 PDZ Domain Binding Site.” Neuron, vol. 28, no. 2, Elsevier, 2000, pp. 485–97, doi:10.1016/S0896-6273(00)00127-6.","short":"H. Boudin, A. Doan, J. Xia, R. Shigemoto, R. Huganir, P. Worley, A. Craig, Neuron 28 (2000) 485–497.","ieee":"H. Boudin et al., “Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site,” Neuron, vol. 28, no. 2. Elsevier, pp. 485–497, 2000.","ama":"Boudin H, Doan A, Xia J, et al. Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. 2000;28(2):485-497. doi:10.1016/S0896-6273(00)00127-6","apa":"Boudin, H., Doan, A., Xia, J., Shigemoto, R., Huganir, R., Worley, P., & Craig, A. (2000). Presynaptic clustering of mGluR7a requires the PICK1 PDZ domain binding site. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)00127-6"},"intvolume":" 28","month":"11","scopus_import":"1","pmid":1,"oa_version":"None","abstract":[{"text":"Aggregation of neurotransmitter receptors at pre- and postsynaptic structures is crucial for efficient neuronal communication. In contrast to the wealth of information about postsynaptic specializations, little is known about the molecular organization of presynaptic membrane proteins. We show here that the metabotropic glutamate receptor mGluR7a, which localizes specifically to presynaptic active zones, interacts in vitro and in vivo with PICK1. Coexpression in heterologous systems induces coclustering dependent upon the extreme C terminus of mGluR7a and the PDZ domain of PICK1. mGluR7a and PICK1 localize to excitatory synapses in hippocampal neurons. Furthermore, whereas transfected mGluR7a clusters at presynaptic sites, mGluR7aΔ3 lacking the PICK1 binding site targets to axons but does not cluster. These results suggest that PICK1 is a component of the presynaptic machinery involved in mGlUR7a aggregation and in modulation of glutamate neurotransmission.","lang":"eng"}],"issue":"2","volume":28,"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"status":"public","type":"journal_article","article_type":"original","_id":"2603","extern":"1","date_updated":"2023-05-03T09:41:55Z"},{"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"volume":21,"issue":"1","abstract":[{"lang":"eng","text":"Spike transmission probability between pyramidal cells and interneurons in the CA1 pyramidal layer was investigated in the behaving rat by the simultaneous recording of neuronal ensembles. Population synchrony was strongest during sharp wave (SPW) bursts. However, the increase was three times larger for pyramidal cells than for interneurons. The contribution of single pyramidal cells to the discharge of interneurons was often large (up to 0.6 probability), as assessed by the presence of significant (<3 ms) peaks in the cross-correlogram. Complex-spike bursts were more effective than single spikes. Single cell contribution was higher between SPW bursts than during SPWs or theta activity. Hence, single pyramidal cells can reliably discharge interneurons, and the probability of spike transmission is behavior dependent."}],"oa_version":"None","pmid":1,"scopus_import":"1","intvolume":" 21","month":"07","date_updated":"2022-08-29T14:03:55Z","extern":"1","_id":"3521","article_type":"original","type":"journal_article","status":"public","year":"1998","publication":"Neuron","day":"01","page":"179 - 189","date_created":"2018-12-11T12:03:46Z","date_published":"1998-07-01T00:00:00Z","doi":"10.1016/S0896-6273(00)80525-5","acknowledgement":"We thank C. King, R. Miles, M. Recce, and the anonymous reviewers for their constructive comments on the manuscript. This work was supported by the National Institutes of Health (NS34994, MH54671 1P41RR09754), the Human Frontier Science Program, and the Whitehall Foundation.","quality_controlled":"1","publisher":"Elsevier","citation":{"ista":"Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. 1998. Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron. 21(1), 179–189.","chicago":"Csicsvari, Jozsef L, Hajima Hirase, András Czurkó, and György Buzsáki. “Reliability and State Dependence of Pyramidal Cell-Interneuron Synapses in the Hippocampus: An Ensemble Approach in the Behaving Rat.” Neuron. Elsevier, 1998. https://doi.org/10.1016/S0896-6273(00)80525-5.","apa":"Csicsvari, J. L., Hirase, H., Czurkó, A., & Buzsáki, G. (1998). Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)80525-5","ama":"Csicsvari JL, Hirase H, Czurkó A, Buzsáki G. Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat. Neuron. 1998;21(1):179-189. doi:10.1016/S0896-6273(00)80525-5","short":"J.L. Csicsvari, H. Hirase, A. Czurkó, G. Buzsáki, Neuron 21 (1998) 179–189.","ieee":"J. L. Csicsvari, H. Hirase, A. Czurkó, and G. Buzsáki, “Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat,” Neuron, vol. 21, no. 1. Elsevier, pp. 179–189, 1998.","mla":"Csicsvari, Jozsef L., et al. “Reliability and State Dependence of Pyramidal Cell-Interneuron Synapses in the Hippocampus: An Ensemble Approach in the Behaving Rat.” Neuron, vol. 21, no. 1, Elsevier, 1998, pp. 179–89, doi:10.1016/S0896-6273(00)80525-5."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["9697862 "]},"publist_id":"2865","author":[{"id":"3FA14672-F248-11E8-B48F-1D18A9856A87","first_name":"Jozsef L","full_name":"Csicsvari, Jozsef L","orcid":"0000-0002-5193-4036","last_name":"Csicsvari"},{"full_name":"Hirase, Hajima","last_name":"Hirase","first_name":"Hajima"},{"full_name":"Czurkó, András","last_name":"Czurkó","first_name":"András"},{"full_name":"Buzsáki, György","last_name":"Buzsáki","first_name":"György"}],"title":"Reliability and state dependence of pyramidal cell-interneuron synapses in the hippocampus: an ensemble approach in the behaving rat"},{"acknowledgement":"We thank Drs. J. Bischofberger, M. Ha¨usser, and I. Vida for critically T.F. reading the manuscript; S. Nestel, B. Joch, M. Winter, B. Freudenberg, and K. Zipfel for excellent technical assistance; and B. Hillers Hestrin, S. for typing. Supported by the DFG (SFB 505/C5 to P. J. and Leibniz program to M. F.)","publisher":"Elsevier","quality_controlled":"1","oa":1,"day":"01","publication":"Neuron","year":"1997","date_published":"1997-06-01T00:00:00Z","doi":"10.1016/S0896-6273(00)80339-6","date_created":"2018-12-11T12:03:34Z","page":"1009 - 1023","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"mla":"Geiger, Jörg, et al. “Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron-Interneuron Synapse.” Neuron, vol. 18, no. 6, Elsevier, 1997, pp. 1009–23, doi:10.1016/S0896-6273(00)80339-6.","ieee":"J. Geiger, J. Lubke, A. Roth, M. Frotscher, and P. M. Jonas, “Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse,” Neuron, vol. 18, no. 6. Elsevier, pp. 1009–1023, 1997.","short":"J. Geiger, J. Lubke, A. Roth, M. Frotscher, P.M. Jonas, Neuron 18 (1997) 1009–1023.","apa":"Geiger, J., Lubke, J., Roth, A., Frotscher, M., & Jonas, P. M. (1997). Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(00)80339-6","ama":"Geiger J, Lubke J, Roth A, Frotscher M, Jonas PM. Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron. 1997;18(6):1009-1023. doi:10.1016/S0896-6273(00)80339-6","chicago":"Geiger, Jörg, Joachim Lubke, Arnd Roth, Michael Frotscher, and Peter M Jonas. “Submillisecond AMPA Receptor-Mediated Signaling at a Principal Neuron-Interneuron Synapse.” Neuron. Elsevier, 1997. https://doi.org/10.1016/S0896-6273(00)80339-6.","ista":"Geiger J, Lubke J, Roth A, Frotscher M, Jonas PM. 1997. Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron. 18(6), 1009–1023."},"title":"Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse","author":[{"first_name":"Jörg","last_name":"Geiger","full_name":"Geiger, Jörg"},{"last_name":"Lubke","full_name":"Lubke, Joachim","first_name":"Joachim"},{"first_name":"Arnd","last_name":"Roth","full_name":"Roth, Arnd"},{"full_name":"Frotscher, Michael","last_name":"Frotscher","first_name":"Michael"},{"orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"}],"publist_id":"2903","external_id":{"pmid":["9208867 "]},"article_processing_charge":"No","pmid":1,"oa_version":"None","abstract":[{"text":"Glutamatergic transmission at a principal neuroninterneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis. Evoked EPSPs with rapid time course (half duration ≃ 4 ms; 34°C) were generated at multiple synaptic contacts established on the interneuron dendrites close to the soma. The underlying postsynaptic conductance change showed a submillisecond rise and decay, due to the precise timing of glutamate release and the rapid deactivation of the postsynaptic AMPA receptors. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.","lang":"eng"}],"month":"06","intvolume":" 18","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/S0896627300803396?via%3Dihub"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","volume":18,"issue":"6","_id":"3484","status":"public","type":"journal_article","article_type":"original","extern":"1","date_updated":"2022-08-22T08:41:54Z"},{"title":"Floating head and masterblind regulate neuronal patterning in the roof of the forebrain","external_id":{"pmid":["9010204"]},"article_processing_charge":"No","author":[{"last_name":"Masai","full_name":"Masai, Ichiro","first_name":"Ichiro"},{"last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J"},{"first_name":"K Anukampa","full_name":"Barth, K Anukampa","last_name":"Barth"},{"full_name":"Macdonald, Rachel","last_name":"Macdonald","first_name":"Rachel"},{"first_name":"Sylwia","full_name":"Adamek, Sylwia","last_name":"Adamek"},{"first_name":"Stephen","full_name":"Wilson, Stephen","last_name":"Wilson"}],"publist_id":"1946","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ista":"Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. 1997. Floating head and masterblind regulate neuronal patterning in the roof of the forebrain. Neuron. 18(1), 43–57.","chicago":"Masai, Ichiro, Carl-Philipp J Heisenberg, K Anukampa Barth, Rachel Macdonald, Sylwia Adamek, and Stephen Wilson. “Floating Head and Masterblind Regulate Neuronal Patterning in the Roof of the Forebrain.” Neuron. Elsevier, 1997. https://doi.org/10.1016/S0896-6273(01)80045-3.","short":"I. Masai, C.-P.J. Heisenberg, K.A. Barth, R. Macdonald, S. Adamek, S. Wilson, Neuron 18 (1997) 43–57.","ieee":"I. Masai, C.-P. J. Heisenberg, K. A. Barth, R. Macdonald, S. Adamek, and S. Wilson, “Floating head and masterblind regulate neuronal patterning in the roof of the forebrain,” Neuron, vol. 18, no. 1. Elsevier, pp. 43–57, 1997.","apa":"Masai, I., Heisenberg, C.-P. J., Barth, K. A., Macdonald, R., Adamek, S., & Wilson, S. (1997). Floating head and masterblind regulate neuronal patterning in the roof of the forebrain. Neuron. Elsevier. https://doi.org/10.1016/S0896-6273(01)80045-3","ama":"Masai I, Heisenberg C-PJ, Barth KA, Macdonald R, Adamek S, Wilson S. Floating head and masterblind regulate neuronal patterning in the roof of the forebrain. Neuron. 1997;18(1):43-57. doi:10.1016/S0896-6273(01)80045-3","mla":"Masai, Ichiro, et al. “Floating Head and Masterblind Regulate Neuronal Patterning in the Roof of the Forebrain.” Neuron, vol. 18, no. 1, Elsevier, 1997, pp. 43–57, doi:10.1016/S0896-6273(01)80045-3."},"date_created":"2018-12-11T12:07:24Z","date_published":"1997-01-01T00:00:00Z","doi":"10.1016/S0896-6273(01)80045-3","page":"43 - 57","publication":"Neuron","day":"01","year":"1997","oa":1,"quality_controlled":"1","publisher":"Elsevier","acknowledgement":"We thank Igor DaMd. Tom Jessell, David Kimelman. Vladimir Koah, Karen Larison. Ingvild Mikkola, Laurie Molday. and Eric Weinberg for probes and antibod-ies: Alex Schist and Juliet Williams for help with the TUNEL tech-nique; Dominic Delaney for analysis of the fih neural plate: Brian Gashing and Geraldine Millard for fish care; Christian Nusslein Volhard for her support: and Corinne Houart. Nigel Holder, and other members of the DBRC for comments on the manuscript. Electron microscopy of the developing epiphysis cited in this study was carried out with the help of Celeste Malinoski. funded by a grant (EY-00168)awarded to Stephen S. Easter. This study was supported by grants from Welcome Trust to S. W. and Human Frontier Science Program to I. M. S.W. is a Wellcome Trust Senior Research Fellow. ","extern":"1","date_updated":"2022-08-18T14:02:49Z","status":"public","type":"journal_article","article_type":"original","_id":"4174","issue":"1","volume":18,"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"intvolume":" 18","month":"01","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/S0896627301800453?via%3Dihub","open_access":"1"}],"scopus_import":"1","oa_version":"Published Version","pmid":1,"abstract":[{"lang":"eng","text":"The epiphysial region of the dorsal diencephalon is the first site at which neurogenesis occurs in the roof of the zebrafish forebrain. We show that the homeobox containing gene floating head (flh) is required for neurogenesis to proceed in the epiphysis. In flh(-) embryos, the first few epiphysial neurons are generated, but beyond the 18 somite stage, neuronal production ceases. In contrast, in masterblind(-) (mbl(-)) embryos, epiphysial neurons are generated throughout the dorsal forebrain. We show that mbl is required to prevent the expression of flh in dorsal forebrain cells rostral to the epiphysis. Furthermore, epiphysial neurons are not ectopically induced in mbl(-)/flh(-) embryos, demonstrating that the epiphysial phenotype of mbl(-) embryos is mediated by ectopic Flh activity. We propose a role for Flh in linking the signaling pathways that regulate regional patterning to the signaling pathways that regulate neurogenesis."}]},{"issue":"5","volume":15,"publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.sciencedirect.com/science/article/pii/089662739590087X?via%3Dihub"}],"month":"11","intvolume":" 15","oa_version":"Published Version","pmid":1,"date_updated":"2022-06-28T08:34:36Z","extern":"1","article_type":"original","type":"journal_article","status":"public","_id":"3461","page":"987 - 990","date_published":"1995-11-01T00:00:00Z","doi":"10.1016/0896-6273(95)90087-X","date_created":"2018-12-11T12:03:27Z","year":"1995","day":"01","publication":"Neuron","publisher":"Elsevier","quality_controlled":"1","oa":1,"author":[{"last_name":"Jonas","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","first_name":"Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Burnashev, Nail","last_name":"Burnashev","first_name":"Nail"}],"publist_id":"2926","external_id":{"pmid":["7576666"]},"article_processing_charge":"No","title":"Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels","citation":{"chicago":"Jonas, Peter M, and Nail Burnashev. “Molecular Mechanisms Controlling Calcium Entry through AMPA-Type Glutamate Receptor Channels.” Neuron. Elsevier, 1995. https://doi.org/10.1016/0896-6273(95)90087-X.","ista":"Jonas PM, Burnashev N. 1995. Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels. Neuron. 15(5), 987–990.","mla":"Jonas, Peter M., and Nail Burnashev. “Molecular Mechanisms Controlling Calcium Entry through AMPA-Type Glutamate Receptor Channels.” Neuron, vol. 15, no. 5, Elsevier, 1995, pp. 987–90, doi:10.1016/0896-6273(95)90087-X.","apa":"Jonas, P. M., & Burnashev, N. (1995). Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(95)90087-X","ama":"Jonas PM, Burnashev N. Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels. Neuron. 1995;15(5):987-990. doi:10.1016/0896-6273(95)90087-X","short":"P.M. Jonas, N. Burnashev, Neuron 15 (1995) 987–990.","ieee":"P. M. Jonas and N. Burnashev, “Molecular mechanisms controlling calcium entry through AMPA-type glutamate receptor channels,” Neuron, vol. 15, no. 5. Elsevier, pp. 987–990, 1995."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17"},{"title":"Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS","author":[{"full_name":"Geiger, Jörg","last_name":"Geiger","first_name":"Jörg"},{"last_name":"Melcher","full_name":"Melcher, Thorsten","first_name":"Thorsten"},{"first_name":"Duk","last_name":"Koh","full_name":"Koh, Duk"},{"last_name":"Sakmann","full_name":"Sakmann, Bert","first_name":"Bert"},{"first_name":"Peter","full_name":"Seeburg, Peter","last_name":"Seeburg"},{"full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M"},{"first_name":"Hannah","last_name":"Monyer","full_name":"Monyer, Hannah"}],"publist_id":"2907","article_processing_charge":"No","external_id":{"pmid":["7619522"]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Geiger, Jörg, Thorsten Melcher, Duk Koh, Bert Sakmann, Peter Seeburg, Peter M Jonas, and Hannah Monyer. “Relative Abundance of Subunit MRNAs Determines Gating and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons in Rat CNS.” Neuron. Elsevier, 1995. https://doi.org/10.1016/0896-6273(95)90076-4.","ista":"Geiger J, Melcher T, Koh D, Sakmann B, Seeburg P, Jonas PM, Monyer H. 1995. Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 15(1), 193–204.","mla":"Geiger, Jörg, et al. “Relative Abundance of Subunit MRNAs Determines Gating and Ca(2+) Permeability of AMPA Receptors in Principal Neurons and Interneurons in Rat CNS.” Neuron, vol. 15, no. 1, Elsevier, 1995, pp. 193–204, doi:10.1016/0896-6273(95)90076-4.","ama":"Geiger J, Melcher T, Koh D, et al. Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. 1995;15(1):193-204. doi:10.1016/0896-6273(95)90076-4","apa":"Geiger, J., Melcher, T., Koh, D., Sakmann, B., Seeburg, P., Jonas, P. M., & Monyer, H. (1995). Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(95)90076-4","short":"J. Geiger, T. Melcher, D. Koh, B. Sakmann, P. Seeburg, P.M. Jonas, H. Monyer, Neuron 15 (1995) 193–204.","ieee":"J. Geiger et al., “Relative abundance of subunit mRNAs determines gating and Ca(2+) permeability of AMPA receptors in principal neurons and interneurons in rat CNS,” Neuron, vol. 15, no. 1. Elsevier, pp. 193–204, 1995."},"doi":"10.1016/0896-6273(95)90076-4","date_published":"1995-07-01T00:00:00Z","date_created":"2018-12-11T12:03:33Z","page":"193 - 204","day":"01","publication":"Neuron","year":"1995","quality_controlled":"1","publisher":"Elsevier","oa":1,"acknowledgement":"We thank Ulla Amtmann for efficient help with the molecular analysis. We also thank M. Kaiser for technical assistance, Dr. J. G. G. Borst for advice concerning preparation of brainstem slices, and Drs. N. Spruston and G. Stuart for critically reading the manuscript. Funded in part by Bundesministerium für Forschung und Technologie grant BCT 364 AZ 321/7291 (P. H. S.) and by Deutsche Forschungsgemeinschaftgrant SFB-3171814(P. J.). J. R. P. G. and T. M. were supported by the graduate program of Molecular and Cellular Neurobiology of the University of Heidelberg. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby\r\nmarked “advertisement” in accordance with 18 USC Section 1734 solely to Indicate this fact.","extern":"1","date_updated":"2022-06-28T07:47:09Z","status":"public","article_type":"original","type":"journal_article","_id":"3480","issue":"1","volume":15,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","month":"07","intvolume":" 15","scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627395900764?via%3Dihub","open_access":"1"}],"pmid":1,"oa_version":"Published Version","abstract":[{"text":"Recording of glutamate-activated currents in membrane patches was combine with RT-PCR-mediated AMPA receptor (AMPAR) subunit mRNA analysis in single identified cells of rat brain slices. Analysis of AMPARs in principal neurons end interneurons of hippocampus and neocortex and in auditory relay neurons and Bergmann glial cells indicates that the GluR-B subunit in its flip version determines formation of receptors with relatively slow gating, whereas the GluR-D subunit promotes assembly of more rapidly gated receptors. The relation between Ca 2+ permeability of AMPAR channels and the relative GluR-B mRNA abundance is consistent with the dominance of this subunit in determining the Ca 2+ permeability of native receptors. The results suggest that differential expression of GluR-B and GluR-D subunit genes, as well as splicing end editing of their mRNAs, account for the differences in gating and Ca 2+ permeability of native AMPAR channels.","lang":"eng"}]},{"status":"public","article_type":"original","type":"journal_article","_id":"2555","extern":"1","date_updated":"2022-06-07T13:39:09Z","intvolume":" 12","month":"06","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627394904413?via%3Dihub"}],"scopus_import":"1","oa_version":"None","pmid":1,"abstract":[{"lang":"eng","text":"Antibodies were raised against two distinct extracellular sequences of the rat mGluR1 metabotropic glutamate receptor expressed as bacterial fusion proteins. Both antibodies specifically reacted with mGluR1 in the rat cerebellum and inhibited the mGluR1 activity as assessed by the analysis of glutamate-stimulated inositol phosphate formation in CHO cells expressing mGluR1. Using these antibodies, we examined the role of mGluR1 in the induction of long-term depression in cultured Purkinje cells. In voltage- clamped Purkinje cells, current induced by iontophoretically applied glutamate was persistently depressed by depolarization of the Purkinje cells in conjunction with the glutamate application. The mGluR1 antibodies completely blocked the depression of glutamate-induced current. The results indicate that activation of mGluR1 is necessary for the induction of cerebellar long-term depression and that these mGluR1 antibodies can be used as selective antagonists."}],"volume":12,"issue":"6","language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"title":"Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells","article_processing_charge":"No","external_id":{"pmid":["7912091 "]},"author":[{"last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Abe, Takaaki","last_name":"Abe","first_name":"Takaaki"},{"first_name":"Sakashi","full_name":"Nomura, Sakashi","last_name":"Nomura"},{"first_name":"Shigetada","last_name":"Nakanishi","full_name":"Nakanishi, Shigetada"},{"last_name":"Hirano","full_name":"Hirano, Tomoo","first_name":"Tomoo"}],"publist_id":"4343","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Shigemoto, Ryuichi, Takaaki Abe, Sakashi Nomura, Shigetada Nakanishi, and Tomoo Hirano. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor Block Long-Term Depression in Cultured Purkinje Cells.” Neuron. Elsevier, 1994. https://doi.org/10.1016/0896-6273(94)90441-3.","ista":"Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. 1994. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron. 12(6), 1245–1255.","mla":"Shigemoto, Ryuichi, et al. “Antibodies Inactivating MGluR1 Metabotropic Glutamate Receptor Block Long-Term Depression in Cultured Purkinje Cells.” Neuron, vol. 12, no. 6, Elsevier, 1994, pp. 1245–55, doi:10.1016/0896-6273(94)90441-3.","ama":"Shigemoto R, Abe T, Nomura S, Nakanishi S, Hirano T. Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron. 1994;12(6):1245-1255. doi:10.1016/0896-6273(94)90441-3","apa":"Shigemoto, R., Abe, T., Nomura, S., Nakanishi, S., & Hirano, T. (1994). Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(94)90441-3","ieee":"R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, and T. Hirano, “Antibodies inactivating mGluR1 metabotropic glutamate receptor block long-term depression in cultured Purkinje cells,” Neuron, vol. 12, no. 6. Elsevier, pp. 1245–1255, 1994.","short":"R. Shigemoto, T. Abe, S. Nomura, S. Nakanishi, T. Hirano, Neuron 12 (1994) 1245–1255."},"publisher":"Elsevier","quality_controlled":"1","acknowledgement":"Correspondence should be addressed to R. S. The photographic help of Mr. Akira Uesugi is gratefully acknowledged. This work has been supported by research grants from Senri Life Science Foundation, the Brain Science Foundation, the Narishige Foundation, and the Ministry of Education, Science, and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked \"advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact. ","date_created":"2018-12-11T11:58:22Z","date_published":"1994-06-01T00:00:00Z","doi":"10.1016/0896-6273(94)90441-3","page":"1245 - 1255","publication":"Neuron","day":"01","year":"1994"},{"acknowledgement":"We are grateful to Mr. Akira Uesugi for photographic help. This work has been supported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part\r\nby the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact. ","quality_controlled":"1","publisher":"Elsevier","year":"1994","publication":"Neuron","day":"01","page":"55 - 66","date_created":"2018-12-11T11:58:22Z","doi":"10.1016/0896-6273(94)90459-6","date_published":"1994-07-01T00:00:00Z","citation":{"ista":"Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. 1994. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 13(1), 55–66.","chicago":"Ohishi, Hitoshi, Reiko Ogawa Meguro, Ryuichi Shigemoto, Takeshi Kaneko, Shigetada Nakanishi, and Noboru Mizuno. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron. Elsevier, 1994. https://doi.org/10.1016/0896-6273(94)90459-6.","ieee":"H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, and N. Mizuno, “Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex,” Neuron, vol. 13, no. 1. Elsevier, pp. 55–66, 1994.","short":"H. Ohishi, R. Ogawa Meguro, R. Shigemoto, T. Kaneko, S. Nakanishi, N. Mizuno, Neuron 13 (1994) 55–66.","apa":"Ohishi, H., Ogawa Meguro, R., Shigemoto, R., Kaneko, T., Nakanishi, S., & Mizuno, N. (1994). Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(94)90459-6","ama":"Ohishi H, Ogawa Meguro R, Shigemoto R, Kaneko T, Nakanishi S, Mizuno N. Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex. Neuron. 1994;13(1):55-66. doi:10.1016/0896-6273(94)90459-6","mla":"Ohishi, Hitoshi, et al. “Immunohistochemical Localization of Metabotropic Glutamate Receptors, MGluR2 and MGluR3, in Rat Cerebellar Cortex.” Neuron, vol. 13, no. 1, Elsevier, 1994, pp. 55–66, doi:10.1016/0896-6273(94)90459-6."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","external_id":{"pmid":["8043281"]},"article_processing_charge":"No","publist_id":"4342","author":[{"full_name":"Ohishi, Hitoshi","last_name":"Ohishi","first_name":"Hitoshi"},{"first_name":"Reiko","full_name":"Ogawa Meguro, Reiko","last_name":"Ogawa Meguro"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto"},{"full_name":"Kaneko, Takeshi","last_name":"Kaneko","first_name":"Takeshi"},{"first_name":"Shigetada","full_name":"Nakanishi, Shigetada","last_name":"Nakanishi"},{"full_name":"Mizuno, Noboru","last_name":"Mizuno","first_name":"Noboru"}],"title":"Immunohistochemical localization of metabotropic glutamate receptors, mGluR2 and mGluR3, in rat cerebellar cortex","abstract":[{"text":"The distribution of the metabotropic glutamate receptors mGluR2 and mGluR3 was immunohistochemically examined in the rat cerebellar cortex at both light and electron microscope levels. An antibody was raised against a fusion protein containing a C-terminal portion of mGluR2. On immunoblot, the antibody reacted with both mGluR2 and mGluR3 in rat brain. mGluR2/3 immunoreactivity was expressed in cell bodies, dendrites, and axon terminals of Golgi cells, as well as in presumed glial processes. Golgi axon terminals with mGluR2/3 immunoreactivity were often encountered in the vicinity of glutamatergic mossy fiber terminals. The results suggest that transmitter glutamate may exert control influences upon Golgi cells not only through dendritic mGluR2/3, but also through axonal mGluR2/3.","lang":"eng"}],"pmid":1,"oa_version":"None","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627394904596?via%3Dihub"}],"scopus_import":"1","intvolume":" 13","month":"07","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"issue":"1","volume":13,"_id":"2557","type":"journal_article","article_type":"original","status":"public","date_updated":"2022-06-07T13:21:58Z","extern":"1"},{"status":"public","type":"journal_article","article_type":"original","_id":"3477","extern":"1","date_updated":"2022-06-03T09:29:36Z","month":"06","intvolume":" 12","scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/0896627394904448?via%3Dihub"}],"pmid":1,"oa_version":"None","abstract":[{"lang":"eng","text":"Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors critically depends on the subunit composition. Using patch-clamp techniques in brain slices, we found that the Ca2+ permeability of native AMPA-type GluRs was markedly higher in nonpyramidal (P(Ca)/P(K) ≃ 0.63) than in pyramidal (P(Ca)/P(K) ≃ 0.05) neurons of rat neocortex. Analysis of mRNA in single cells indicated that the relative abundance of GluR-B-specific mRNA was significantly lower in nonpyramidal (GluR-B/GluR-non-B ≃ 0.3) than in pyramidal (GluR-B/GluR-non-B ≃ 3) cells. This suggests that differences in relative abundance of GluR-B- specific mRNA generate functional diversity of AMPA-type GluRs in neurons with respect to Ca2+ permeability."}],"volume":12,"issue":"6","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","title":"Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression","publist_id":"2910","author":[{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","first_name":"Peter M","full_name":"Jonas, Peter M","orcid":"0000-0001-5001-4804","last_name":"Jonas"},{"last_name":"Racca","full_name":"Racca, Claudia","first_name":"Claudia"},{"first_name":"Bert","last_name":"Sakmann","full_name":"Sakmann, Bert"},{"last_name":"Seeburg","full_name":"Seeburg, Peter","first_name":"Peter"},{"first_name":"Hannah","full_name":"Monyer, Hannah","last_name":"Monyer"}],"article_processing_charge":"No","external_id":{"pmid":["8011338 "]},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"ieee":"P. M. Jonas, C. Racca, B. Sakmann, P. Seeburg, and H. Monyer, “Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression,” Neuron, vol. 12, no. 6. Elsevier, pp. 1281–1289, 1994.","short":"P.M. Jonas, C. Racca, B. Sakmann, P. Seeburg, H. Monyer, Neuron 12 (1994) 1281–1289.","ama":"Jonas PM, Racca C, Sakmann B, Seeburg P, Monyer H. Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron. 1994;12(6):1281-1289. doi:10.1016/0896-6273(94)90444-8","apa":"Jonas, P. M., Racca, C., Sakmann, B., Seeburg, P., & Monyer, H. (1994). Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(94)90444-8","mla":"Jonas, Peter M., et al. “Differences in Ca(2+) Permeability of AMPA-Type Glutamate Receptor Channels in Neocortical Neurons Caused by Differential GluR-B Subunit Expression.” Neuron, vol. 12, no. 6, Elsevier, 1994, pp. 1281–89, doi:10.1016/0896-6273(94)90444-8.","ista":"Jonas PM, Racca C, Sakmann B, Seeburg P, Monyer H. 1994. Differences in Ca(2+) permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron. 12(6), 1281–1289.","chicago":"Jonas, Peter M, Claudia Racca, Bert Sakmann, Peter Seeburg, and Hannah Monyer. “Differences in Ca(2+) Permeability of AMPA-Type Glutamate Receptor Channels in Neocortical Neurons Caused by Differential GluR-B Subunit Expression.” Neuron. Elsevier, 1994. https://doi.org/10.1016/0896-6273(94)90444-8."},"quality_controlled":"1","publisher":"Elsevier","acknowledgement":"We thank Drs. B. Lambolez and J. Rossier for helping to establish the method of single-cell PCR, Dr. M. Frotscher for help with cell identification, Dr. N. Spruston for critically reading the manuscript, and M. Kaiser and U. Keller for technical assistance. This work was supported in part by BMFT grant BCT 364 AZ 3211 7291 (P. H. S.) and by DFG grant SFB-317/B14 (P. J.). The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.","date_published":"1994-06-01T00:00:00Z","doi":"10.1016/0896-6273(94)90444-8","date_created":"2018-12-11T12:03:32Z","page":"1281 - 1289","day":"01","publication":"Neuron","year":"1994"},{"acknowledgement":"We are grateful to Drs. Y. Sugimoto, A. Ichikawa, J. Ogasawara, R. Fukunaga, H. Aino, and A. Baba for discussion and advice. We also thank Ms. K. Mimura for secretarial assistance. This work was supported in part by the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact.","quality_controlled":"1","publisher":"Elsevier","year":"1993","day":"01","publication":"Neuron","page":"333 - 342","doi":"10.1016/0896-6273(93)90188-W","date_published":"1993-08-01T00:00:00Z","date_created":"2018-12-11T11:58:17Z","citation":{"ista":"Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S. 1993. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron. 11(2), 333–342.","chicago":"Hashimoto, Hitoshi, Takeshi Ishihara, Ryuichi Shigemoto, Kensaku Mori, and Shigekazu Nagata. “ Molecular Cloning and Tissue Distribution of a Receptor for Pituitary Adenylate Cyclase-Activating Polypeptide.” Neuron. Elsevier, 1993. https://doi.org/10.1016/0896-6273(93)90188-W.","apa":"Hashimoto, H., Ishihara, T., Shigemoto, R., Mori, K., & Nagata, S. (1993). Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(93)90188-W","ama":"Hashimoto H, Ishihara T, Shigemoto R, Mori K, Nagata S. Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide. Neuron. 1993;11(2):333-342. doi:10.1016/0896-6273(93)90188-W","ieee":"H. Hashimoto, T. Ishihara, R. Shigemoto, K. Mori, and S. Nagata, “ Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide,” Neuron, vol. 11, no. 2. Elsevier, pp. 333–342, 1993.","short":"H. Hashimoto, T. Ishihara, R. Shigemoto, K. Mori, S. Nagata, Neuron 11 (1993) 333–342.","mla":"Hashimoto, Hitoshi, et al. “ Molecular Cloning and Tissue Distribution of a Receptor for Pituitary Adenylate Cyclase-Activating Polypeptide.” Neuron, vol. 11, no. 2, Elsevier, 1993, pp. 333–42, doi:10.1016/0896-6273(93)90188-W."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","publist_id":"4355","author":[{"last_name":"Hashimoto","full_name":"Hashimoto, Hitoshi","first_name":"Hitoshi"},{"first_name":"Takeshi","full_name":"Ishihara, Takeshi","last_name":"Ishihara"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"first_name":"Kensaku","last_name":"Mori","full_name":"Mori, Kensaku"},{"first_name":"Shigekazu","last_name":"Nagata","full_name":"Nagata, Shigekazu"}],"external_id":{"pmid":["8394723"]},"article_processing_charge":"No","title":" Molecular cloning and tissue distribution of a receptor for pituitary adenylate cyclase-activating polypeptide","abstract":[{"lang":"eng","text":"Pituitary adenylate cyclase-activating polypeptide (PACAP) is a polypeptide hormone related to vasoactive intestinal polypeptide (VIP). Rat PACAP receptor cDNA was isolated from a brain cDNA library by cross-hybridization with rat VIP receptor cDNA. The recombinant PACAP receptor expressed in COS cells bound PACAP with about 1000 times higher affinity than VIP, and PACAP stimulated adenylate cyclase through the cloned PACAP receptor. The rat PACAP receptor consists of 495 amino acids, contains seven transmembrane segments, and has a significant similarity with other Gs-coupled receptors, such as VIP, glucagon, and secretin receptors. PACAP receptor mRNA was abundantly expressed in the brain, but not in the peripheral tissues except for the adrenal gland. In situ hybridization revealed a high level of expression of PACAP receptor mRNA in the hippocampal dentate gyrus, olfactory bulb, and cerebellar cortex."}],"oa_version":"None","pmid":1,"scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/089662739390188W?via%3Dihub"}],"month":"08","intvolume":" 11","publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","language":[{"iso":"eng"}],"issue":"2","volume":11,"_id":"2543","type":"journal_article","article_type":"original","status":"public","date_updated":"2022-03-31T09:56:46Z","extern":"1"},{"citation":{"short":"Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, S. Nakanishi, Neuron 8 (1992) 169–179.","ieee":"Y. Tanabe, M. Masu, T. Ishii, R. Shigemoto, and S. Nakanishi, “A family of metabotropic glutamate receptors,” Neuron, vol. 8, no. 1. Elsevier, pp. 169–179, 1992.","apa":"Tanabe, Y., Masu, M., Ishii, T., Shigemoto, R., & Nakanishi, S. (1992). A family of metabotropic glutamate receptors. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90118-W","ama":"Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. A family of metabotropic glutamate receptors. Neuron. 1992;8(1):169-179. doi:10.1016/0896-6273(92)90118-W","mla":"Tanabe, Yasuto, et al. “A Family of Metabotropic Glutamate Receptors.” Neuron, vol. 8, no. 1, Elsevier, 1992, pp. 169–79, doi:10.1016/0896-6273(92)90118-W.","ista":"Tanabe Y, Masu M, Ishii T, Shigemoto R, Nakanishi S. 1992. A family of metabotropic glutamate receptors. Neuron. 8(1), 169–179.","chicago":"Tanabe, Yasuto, Masayuki Masu, Takahiro Ishii, Ryuichi Shigemoto, and Shigetada Nakanishi. “A Family of Metabotropic Glutamate Receptors.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90118-W."},"user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","article_processing_charge":"No","external_id":{"pmid":["1309649 "]},"publist_id":"4417","author":[{"first_name":"Yasuto","full_name":"Tanabe, Yasuto","last_name":"Tanabe"},{"first_name":"Masayuki","full_name":"Masu, Masayuki","last_name":"Masu"},{"first_name":"Takahiro","full_name":"Ishii, Takahiro","last_name":"Ishii"},{"first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi","orcid":"0000-0001-8761-9444"},{"full_name":"Nakanishi, Shigetada","last_name":"Nakanishi","first_name":"Shigetada"}],"title":"A family of metabotropic glutamate receptors","year":"1992","publication":"Neuron","day":"01","page":"169 - 179","date_created":"2018-12-11T11:57:56Z","doi":"10.1016/0896-6273(92)90118-W","date_published":"1992-01-01T00:00:00Z","acknowledgement":"We are grateful to Noboru Mizuno for helpful discussion and Akira Uesugi for photographic assistance. This work was sup. ported in part by research grants from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part by the payment of page charges. This article must therefore be hereby marked \"advertisement\" in accordance with 18 USC Sec-tion 1734 solely to indicate this fact. ","quality_controlled":"1","publisher":"Elsevier","date_updated":"2022-03-21T10:17:07Z","extern":"1","_id":"2484","article_type":"original","type":"journal_article","status":"public","publication_status":"published","publication_identifier":{"issn":["0896-6273"]},"language":[{"iso":"eng"}],"issue":"1","volume":8,"abstract":[{"text":"Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is expressed in some particular neuronal cells different from those expressing mGluR1 and mediates an efficient inhibition of forskolin-stimulated cAMP formation in cDNA- transfected cells. The mGluRs thus form a novel family of G protein-coupled receptors that differ in their signal transduction and expression patterns.","lang":"eng"}],"pmid":1,"oa_version":"None","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/089662739290118W?via%3Dihub"}],"scopus_import":"1","intvolume":" 8","month":"01"},{"extern":"1","date_updated":"2022-03-17T13:33:07Z","status":"public","article_type":"original","type":"journal_article","_id":"2534","volume":8,"issue":"4","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0896-6273"]},"publication_status":"published","month":"04","intvolume":" 8","scopus_import":"1","main_file_link":[{"url":"https://www.sciencedirect.com/science/article/pii/089662739290101I?via%3Dihub"}],"pmid":1,"oa_version":"None","abstract":[{"text":"Vasoactive intestinal polypeptide (VIP), a 28 amino acid peptide hormone, plays many physiological roles in the peripheral and central nerve systems. A functional cDNA clone of the VIP receptor was isolated from a rat lung cDNA library by cross-hybridization with the secretin receptor cDNA. VIP bound the cloned VIP receptor expressed in mouse COP cells and stimulated adenylate cyclase through the cloned receptor. The rat VIP receptor consists of 459 amino acids with a calculated Mr of 52,054 and contains seven transmembrane segments. It is structurally related to the secretin, calcitonin, and parathyroid hormone receptors, suggesting that they constitute a new subfamily of the G5 protein - coupled receptors. VIP receptor mRNA was detected in various rat tissues including liver, lung, intestines, and brain. In situ hybridization revealed that VIP receptor mRNA is widely distributed in neuronal cells of the adult rat brain, with a relatively high expression in the cerebral cortex and hippocampus.","lang":"eng"}],"title":"Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide","author":[{"last_name":"Ishihara","full_name":"Ishihara, Takeshi","first_name":"Takeshi"},{"last_name":"Shigemoto","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Mori, Kensaku","last_name":"Mori","first_name":"Kensaku"},{"full_name":"Takahashi, Kenji","last_name":"Takahashi","first_name":"Kenji"},{"last_name":"Nagata","full_name":"Nagata, Shigekazu","first_name":"Shigekazu"}],"publist_id":"4363","external_id":{"pmid":["1314625"]},"article_processing_charge":"No","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","citation":{"chicago":"Ishihara, Takeshi, Ryuichi Shigemoto, Kensaku Mori, Kenji Takahashi, and Shigekazu Nagata. “Functional Expression and Tissue Distribution of a Novel Receptor for Vasoactive Intestinal Polypeptide.” Neuron. Elsevier, 1992. https://doi.org/10.1016/0896-6273(92)90101-I.","ista":"Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. 1992. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. 8(4), 811–819.","mla":"Ishihara, Takeshi, et al. “Functional Expression and Tissue Distribution of a Novel Receptor for Vasoactive Intestinal Polypeptide.” Neuron, vol. 8, no. 4, Elsevier, 1992, pp. 811–19, doi:10.1016/0896-6273(92)90101-I.","ieee":"T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, and S. Nagata, “Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide,” Neuron, vol. 8, no. 4. Elsevier, pp. 811–819, 1992.","short":"T. Ishihara, R. Shigemoto, K. Mori, K. Takahashi, S. Nagata, Neuron 8 (1992) 811–819.","apa":"Ishihara, T., Shigemoto, R., Mori, K., Takahashi, K., & Nagata, S. (1992). Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. Elsevier. https://doi.org/10.1016/0896-6273(92)90101-I","ama":"Ishihara T, Shigemoto R, Mori K, Takahashi K, Nagata S. Functional expression and tissue distribution of a novel receptor for vasoactive intestinal polypeptide. Neuron. 1992;8(4):811-819. doi:10.1016/0896-6273(92)90101-I"},"doi":"10.1016/0896-6273(92)90101-I","date_published":"1992-04-01T00:00:00Z","date_created":"2018-12-11T11:58:14Z","page":"811 - 819","day":"01","publication":"Neuron","year":"1992","publisher":"Elsevier","quality_controlled":"1","acknowledgement":"We thank Drs. R. Yoshida, K. Katoh, and K. lmamura for help with the in situ hybridization, Dr. M. Nishizawa for discussion, and Ms. M. lkeda for secretarial assistance. This work was supported in part by a Grant-in-Aid from the Ministry of Education, Science and Culture of Japan. The costs of publication of this article were defrayed in part\r\nby the payment of page charges. This article must therefore be hereby marked “advertisement” in accordance with 18 USC Section 1734 solely to indicate this fact."}]