---
OA_place: publisher
OA_type: hybrid
_id: '17459'
abstract:
- lang: eng
  text: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease
    worldwide. AD is a highly complex disease with different subtypes. Many elements
    of AD pathophysiology have been described, but if/how they interact with each
    other or which mechanisms are important in which patients is still unclear. Langerhans
    cells (LCs) are antigen-presenting cells (APCs) in the epidermis. Depending on
    the context, they can act either pro- or anti-inflammatory. Many different studies
    have investigated LCs in the context of AD and found them to be connected to all
    major mechanisms of AD pathophysiology. As APCs, LCs recruit other immune cells
    and shape the immune response, especially adaptive immunity via polarization of
    T cells. As sentinel cells, LCs are primary sensors of the skin microbiome and
    are important for the decision of immunity versus tolerance. LCs are also involved
    with the integrity of the skin barrier by influencing tight junctions. Finally,
    LCs are important cells in the neuro-immune crosstalk in the skin. In this review,
    we provide an overview about the many different roles of LCs in AD. Understanding
    LCs might bring us closer to a more complete understanding of this highly complex
    disease. Potentially, modulating LCs might offer new options for targeted therapies
    for AD patients.
acknowledgement: This work was supported by the CK-CARE of the KühneFoundation, Switzerland;
  the China Scholarship Counciland Shanghai Biocelline Enterprise Co. Ltd, China.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Yi
  full_name: Pan, Yi
  last_name: Pan
- first_name: Mathias
  full_name: Hochgerner, Mathias
  last_name: Hochgerner
- first_name: Malgorzata Anna
  full_name: Cichon, Malgorzata Anna
  id: d63197a3-c188-11ed-9387-8d33a3f13871
  last_name: Cichon
- first_name: Theresa
  full_name: Benezeder, Theresa
  last_name: Benezeder
- first_name: Thomas
  full_name: Bieber, Thomas
  last_name: Bieber
- first_name: Peter
  full_name: Wolf, Peter
  last_name: Wolf
citation:
  ama: 'Pan Y, Hochgerner M, Cichon MA, Benezeder T, Bieber T, Wolf P. Langerhans
    cells: Central players in the pathophysiology of atopic dermatitis. <i>Journal
    of the European Academy of Dermatology and Venereology</i>. 2025;39(2):278-289.
    doi:<a href="https://doi.org/10.1111/jdv.20291">10.1111/jdv.20291</a>'
  apa: 'Pan, Y., Hochgerner, M., Cichon, M. A., Benezeder, T., Bieber, T., &#38; Wolf,
    P. (2025). Langerhans cells: Central players in the pathophysiology of atopic
    dermatitis. <i>Journal of the European Academy of Dermatology and Venereology</i>.
    Wiley. <a href="https://doi.org/10.1111/jdv.20291">https://doi.org/10.1111/jdv.20291</a>'
  chicago: 'Pan, Yi, Mathias Hochgerner, Malgorzata Anna Cichon, Theresa Benezeder,
    Thomas Bieber, and Peter Wolf. “Langerhans Cells: Central Players in the Pathophysiology
    of Atopic Dermatitis.” <i>Journal of the European Academy of Dermatology and Venereology</i>.
    Wiley, 2025. <a href="https://doi.org/10.1111/jdv.20291">https://doi.org/10.1111/jdv.20291</a>.'
  ieee: 'Y. Pan, M. Hochgerner, M. A. Cichon, T. Benezeder, T. Bieber, and P. Wolf,
    “Langerhans cells: Central players in the pathophysiology of atopic dermatitis,”
    <i>Journal of the European Academy of Dermatology and Venereology</i>, vol. 39,
    no. 2. Wiley, pp. 278–289, 2025.'
  ista: 'Pan Y, Hochgerner M, Cichon MA, Benezeder T, Bieber T, Wolf P. 2025. Langerhans
    cells: Central players in the pathophysiology of atopic dermatitis. Journal of
    the European Academy of Dermatology and Venereology. 39(2), 278–289.'
  mla: 'Pan, Yi, et al. “Langerhans Cells: Central Players in the Pathophysiology
    of Atopic Dermatitis.” <i>Journal of the European Academy of Dermatology and Venereology</i>,
    vol. 39, no. 2, Wiley, 2025, pp. 278–89, doi:<a href="https://doi.org/10.1111/jdv.20291">10.1111/jdv.20291</a>.'
  short: Y. Pan, M. Hochgerner, M.A. Cichon, T. Benezeder, T. Bieber, P. Wolf, Journal
    of the European Academy of Dermatology and Venereology 39 (2025) 278–289.
date_created: 2024-08-25T22:01:07Z
date_published: 2025-02-01T00:00:00Z
date_updated: 2025-05-19T13:58:50Z
day: '01'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1111/jdv.20291
external_id:
  isi:
  - '001292894900001'
  pmid:
  - '39157943'
file:
- access_level: open_access
  checksum: 12555ddb3490daf10b8d44e334e7312e
  content_type: application/pdf
  creator: dernst
  date_created: 2025-04-16T09:59:37Z
  date_updated: 2025-04-16T09:59:37Z
  file_id: '19583'
  file_name: 2025_JEADV_Pan.pdf
  file_size: 457698
  relation: main_file
  success: 1
file_date_updated: 2025-04-16T09:59:37Z
has_accepted_license: '1'
intvolume: '        39'
isi: 1
issue: '2'
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 278-289
pmid: 1
publication: Journal of the European Academy of Dermatology and Venereology
publication_identifier:
  eissn:
  - 1468-3083
  issn:
  - 0926-9959
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Langerhans cells: Central players in the pathophysiology of atopic dermatitis'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2025'
...