---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19718'
abstract:
- lang: eng
  text: The cerebral cortex is arguably the most complex organ in humans. The cortical
    architecture is characterized by a remarkable diversity of neuronal and glial
    cell types that make up its neuronal circuits. Following a precise temporally
    ordered program, radial glia progenitor (RGP) cells generate all cortical excitatory
    projection neurons and glial cell-types. Cortical excitatory projection neurons
    are produced either directly or via intermediate progenitors, through indirect
    neurogenesis. How the extensive cortical cell-type diversity is generated during
    cortex development remains, however, a fundamental open question. How do RGPs
    quantitatively and qualitatively generate all the neocortical neurons? How does
    direct and indirect neurogenesis contribute to the establishment of neuronal and
    lineage heterogeneity? Whether RGPs represent a homogeneous and/or multipotent
    progenitor population, or if RGPs consist of heterogeneous groups is currently
    also not known. In this review, we will summarize the latest findings that contributed
    to a deeper insight into the above key questions.
acknowledgement: We wish to thank all members of the Hippenmeyer laboratory at ISTA
  for exciting discussions on the subject of this review. We apologize to colleagues
  whose work we could not cite and/or discuss in the frame of the available space.
  Work in the Hippenmeyer laboratory on the discussed topic is supported by ISTA institutional
  funds, an EMBO LTF (ALTF 994–2023) to F.P, and FWF SFB F78 to S.H.
article_number: '103046'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fabrizia
  full_name: Pipicelli, Fabrizia
  id: 649134fd-d012-11ed-8f82-db1e5050f9ba
  last_name: Pipicelli
- first_name: Ana
  full_name: Villalba Requena, Ana
  id: 68cb85a0-39f7-11eb-9559-9aaab4f6a247
  last_name: Villalba Requena
  orcid: 0000-0002-5615-5277
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: Pipicelli F, Villalba Requena A, Hippenmeyer S. How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex. <i>Current
    Opinion in Neurobiology</i>. 2025;93. doi:<a href="https://doi.org/10.1016/j.conb.2025.103046">10.1016/j.conb.2025.103046</a>
  apa: Pipicelli, F., Villalba Requena, A., &#38; Hippenmeyer, S. (2025). How radial
    glia progenitor lineages generate cell-type diversity in the developing cerebral
    cortex. <i>Current Opinion in Neurobiology</i>. Elsevier. <a href="https://doi.org/10.1016/j.conb.2025.103046">https://doi.org/10.1016/j.conb.2025.103046</a>
  chicago: Pipicelli, Fabrizia, Ana Villalba Requena, and Simon Hippenmeyer. “How
    Radial Glia Progenitor Lineages Generate Cell-Type Diversity in the Developing
    Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>. Elsevier, 2025. <a href="https://doi.org/10.1016/j.conb.2025.103046">https://doi.org/10.1016/j.conb.2025.103046</a>.
  ieee: F. Pipicelli, A. Villalba Requena, and S. Hippenmeyer, “How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex,” <i>Current
    Opinion in Neurobiology</i>, vol. 93. Elsevier, 2025.
  ista: Pipicelli F, Villalba Requena A, Hippenmeyer S. 2025. How radial glia progenitor
    lineages generate cell-type diversity in the developing cerebral cortex. Current
    Opinion in Neurobiology. 93, 103046.
  mla: Pipicelli, Fabrizia, et al. “How Radial Glia Progenitor Lineages Generate Cell-Type
    Diversity in the Developing Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>,
    vol. 93, 103046, Elsevier, 2025, doi:<a href="https://doi.org/10.1016/j.conb.2025.103046">10.1016/j.conb.2025.103046</a>.
  short: F. Pipicelli, A. Villalba Requena, S. Hippenmeyer, Current Opinion in Neurobiology
    93 (2025).
corr_author: '1'
date_created: 2025-05-20T10:20:09Z
date_published: 2025-08-01T00:00:00Z
date_updated: 2025-12-30T10:54:14Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.conb.2025.103046
external_id:
  isi:
  - '001496227000001'
  pmid:
  - '40383049'
file:
- access_level: open_access
  checksum: 05bacb4acbe6275d43e873dec9ba1d52
  content_type: application/pdf
  creator: dernst
  date_created: 2025-12-30T08:25:49Z
  date_updated: 2025-12-30T08:25:49Z
  file_id: '20894'
  file_name: 2025_CurrentOpNeurobiology_Pipicelli.pdf
  file_size: 1592649
  relation: main_file
  success: 1
file_date_updated: 2025-12-30T08:25:49Z
has_accepted_license: '1'
intvolume: '        93'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
  grant_number: F7805
  name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
    Mechanisms of Neural Stem Cell Lineage Progression
- _id: 7c084566-9f16-11ee-852c-c88a1dbbf1cf
  grant_number: ALTF 994-2023
  name: Role of cell lineage in generating cell-type diversity in developing neocortex’
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: How radial glia progenitor lineages generate cell-type diversity in the developing
  cerebral cortex
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 93
year: '2025'
...
---
_id: '12679'
abstract:
- lang: eng
  text: How to generate a brain of correct size and with appropriate cell-type diversity
    during development is a major question in Neuroscience. In the developing neocortex,
    radial glial progenitor (RGP) cells are the main neural stem cells that produce
    cortical excitatory projection neurons, glial cells, and establish the prospective
    postnatal stem cell niche in the lateral ventricles. RGPs follow a tightly orchestrated
    developmental program that when disrupted can result in severe cortical malformations
    such as microcephaly and megalencephaly. The precise cellular and molecular mechanisms
    instructing faithful RGP lineage progression are however not well understood.
    This review will summarize recent conceptual advances that contribute to our understanding
    of the general principles of RGP lineage progression.
acknowledgement: "I wish to thank all current and past members of the Hippenmeyer
  laboratory at ISTA for exciting discussions on the subject of this review. I apologize
  to colleagues whose work I could not cite and/or discuss in the frame of the available
  space. Work in the Hippenmeyer laboratory on the\r\ndiscussed topic is supported
  by ISTA institutional funds, FWF SFB F78 to S.H., and the European Research Council
  (ERC) under the European Union’s Horizon 2020 Research and Innovation Programme
  (grant agree-ment no. 725780 LinPro) to SH."
article_number: '102695'
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
citation:
  ama: 'Hippenmeyer S. Principles of neural stem cell lineage progression: Insights
    from developing cerebral cortex. <i>Current Opinion in Neurobiology</i>. 2023;79(4).
    doi:<a href="https://doi.org/10.1016/j.conb.2023.102695">10.1016/j.conb.2023.102695</a>'
  apa: 'Hippenmeyer, S. (2023). Principles of neural stem cell lineage progression:
    Insights from developing cerebral cortex. <i>Current Opinion in Neurobiology</i>.
    Elsevier. <a href="https://doi.org/10.1016/j.conb.2023.102695">https://doi.org/10.1016/j.conb.2023.102695</a>'
  chicago: 'Hippenmeyer, Simon. “Principles of Neural Stem Cell Lineage Progression:
    Insights from Developing Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>.
    Elsevier, 2023. <a href="https://doi.org/10.1016/j.conb.2023.102695">https://doi.org/10.1016/j.conb.2023.102695</a>.'
  ieee: 'S. Hippenmeyer, “Principles of neural stem cell lineage progression: Insights
    from developing cerebral cortex,” <i>Current Opinion in Neurobiology</i>, vol.
    79, no. 4. Elsevier, 2023.'
  ista: 'Hippenmeyer S. 2023. Principles of neural stem cell lineage progression:
    Insights from developing cerebral cortex. Current Opinion in Neurobiology. 79(4),
    102695.'
  mla: 'Hippenmeyer, Simon. “Principles of Neural Stem Cell Lineage Progression: Insights
    from Developing Cerebral Cortex.” <i>Current Opinion in Neurobiology</i>, vol.
    79, no. 4, 102695, Elsevier, 2023, doi:<a href="https://doi.org/10.1016/j.conb.2023.102695">10.1016/j.conb.2023.102695</a>.'
  short: S. Hippenmeyer, Current Opinion in Neurobiology 79 (2023).
corr_author: '1'
date_created: 2023-02-26T12:24:21Z
date_published: 2023-04-01T00:00:00Z
date_updated: 2025-04-15T08:23:06Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1016/j.conb.2023.102695
ec_funded: 1
external_id:
  isi:
  - '000953497700001'
  pmid:
  - '36842274'
file:
- access_level: open_access
  checksum: 4d11c4ca87e6cbc4d2ac46d3225ea615
  content_type: application/pdf
  creator: dernst
  date_created: 2023-08-16T12:29:06Z
  date_updated: 2023-08-16T12:29:06Z
  file_id: '14071'
  file_name: 2023_CurrentOpinionNeurobio_Hippenmeyer.pdf
  file_size: 1787894
  relation: main_file
  success: 1
file_date_updated: 2023-08-16T12:29:06Z
has_accepted_license: '1'
intvolume: '        79'
isi: 1
issue: '4'
keyword:
- General Neuroscience
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 059F6AB4-7A3F-11EA-A408-12923DDC885E
  grant_number: F7805
  name: Stem Cell Modulation in Neural Development and Regeneration/ P05-Molecular
    Mechanisms of Neural Stem Cell Lineage Progression
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Principles of neural stem cell lineage progression: Insights from developing
  cerebral cortex'
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 79
year: '2023'
...
---
_id: '8019'
abstract:
- lang: eng
  text: Synaptic plasticity is essential for the function of neural systems. It sets
    up initial circuitry and adjusts connection strengths according to the maintenance
    requirements of its host networks. Like all things biological, synaptic plasticity
    must rely on genetic programs to provide the molecular components of its machinery
    to integrate ongoing, often multi-sensory experience without destabilising effects.
    Because of its fundamental importance to healthy behaviour, understanding plasticity
    is thought to hold the key to understanding the brain. There are innumerable ways
    to approach this topic and a complete review of its status quo would be impossible.
    In the current issue we dig into some of the finer points of synaptic plasticity,
    starting small, at the level of genes, and slowly zooming out to synapses, populations
    of synapses, and finally entire systems and brain regions. At each level, we tried
    to represent different perspectives, different systems, and approaches to the
    same questions to give a broad sampling of how synaptic plasticity is being studied.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: Leslie C
  full_name: Griffith, Leslie C
  last_name: Griffith
citation:
  ama: 'Vogels TP, Griffith LC. Editorial overview: Neurobiology of learning and plasticity
    2017. <i>Current Opinion in Neurobiology</i>. 2017;43:A1-A5. doi:<a href="https://doi.org/10.1016/j.conb.2017.04.002">10.1016/j.conb.2017.04.002</a>'
  apa: 'Vogels, T. P., &#38; Griffith, L. C. (2017). Editorial overview: Neurobiology
    of learning and plasticity 2017. <i>Current Opinion in Neurobiology</i>. Elsevier.
    <a href="https://doi.org/10.1016/j.conb.2017.04.002">https://doi.org/10.1016/j.conb.2017.04.002</a>'
  chicago: 'Vogels, Tim P, and Leslie C Griffith. “Editorial Overview: Neurobiology
    of Learning and Plasticity 2017.” <i>Current Opinion in Neurobiology</i>. Elsevier,
    2017. <a href="https://doi.org/10.1016/j.conb.2017.04.002">https://doi.org/10.1016/j.conb.2017.04.002</a>.'
  ieee: 'T. P. Vogels and L. C. Griffith, “Editorial overview: Neurobiology of learning
    and plasticity 2017,” <i>Current Opinion in Neurobiology</i>, vol. 43. Elsevier,
    pp. A1–A5, 2017.'
  ista: 'Vogels TP, Griffith LC. 2017. Editorial overview: Neurobiology of learning
    and plasticity 2017. Current Opinion in Neurobiology. 43, A1–A5.'
  mla: 'Vogels, Tim P., and Leslie C. Griffith. “Editorial Overview: Neurobiology
    of Learning and Plasticity 2017.” <i>Current Opinion in Neurobiology</i>, vol.
    43, Elsevier, 2017, pp. A1–5, doi:<a href="https://doi.org/10.1016/j.conb.2017.04.002">10.1016/j.conb.2017.04.002</a>.'
  short: T.P. Vogels, L.C. Griffith, Current Opinion in Neurobiology 43 (2017) A1–A5.
date_created: 2020-06-25T13:03:30Z
date_published: 2017-04-17T00:00:00Z
date_updated: 2021-01-12T08:16:33Z
day: '17'
doi: 10.1016/j.conb.2017.04.002
extern: '1'
external_id:
  pmid:
  - '28427877'
intvolume: '        43'
language:
- iso: eng
month: '04'
oa_version: None
page: A1-A5
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'Editorial overview: Neurobiology of learning and plasticity 2017'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 43
year: '2017'
...
---
_id: '730'
abstract:
- lang: eng
  text: Neural responses are highly structured, with population activity restricted
    to a small subset of the astronomical range of possible activity patterns. Characterizing
    these statistical regularities is important for understanding circuit computation,
    but challenging in practice. Here we review recent approaches based on the maximum
    entropy principle used for quantifying collective behavior in neural activity.
    We highlight recent models that capture population-level statistics of neural
    data, yielding insights into the organization of the neural code and its biological
    substrate. Furthermore, the MaxEnt framework provides a general recipe for constructing
    surrogate ensembles that preserve aspects of the data, but are otherwise maximally
    unstructured. This idea can be used to generate a hierarchy of controls against
    which rigorous statistical tests are possible.
article_processing_charge: No
author:
- first_name: Cristina
  full_name: Savin, Cristina
  id: 3933349E-F248-11E8-B48F-1D18A9856A87
  last_name: Savin
- first_name: Gasper
  full_name: Tkacik, Gasper
  id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
  last_name: Tkacik
  orcid: 0000-0002-6699-1455
citation:
  ama: Savin C, Tkačik G. Maximum entropy models as a tool for building precise neural
    controls. <i>Current Opinion in Neurobiology</i>. 2017;46:120-126. doi:<a href="https://doi.org/10.1016/j.conb.2017.08.001">10.1016/j.conb.2017.08.001</a>
  apa: Savin, C., &#38; Tkačik, G. (2017). Maximum entropy models as a tool for building
    precise neural controls. <i>Current Opinion in Neurobiology</i>. Elsevier. <a
    href="https://doi.org/10.1016/j.conb.2017.08.001">https://doi.org/10.1016/j.conb.2017.08.001</a>
  chicago: Savin, Cristina, and Gašper Tkačik. “Maximum Entropy Models as a Tool for
    Building Precise Neural Controls.” <i>Current Opinion in Neurobiology</i>. Elsevier,
    2017. <a href="https://doi.org/10.1016/j.conb.2017.08.001">https://doi.org/10.1016/j.conb.2017.08.001</a>.
  ieee: C. Savin and G. Tkačik, “Maximum entropy models as a tool for building precise
    neural controls,” <i>Current Opinion in Neurobiology</i>, vol. 46. Elsevier, pp.
    120–126, 2017.
  ista: Savin C, Tkačik G. 2017. Maximum entropy models as a tool for building precise
    neural controls. Current Opinion in Neurobiology. 46, 120–126.
  mla: Savin, Cristina, and Gašper Tkačik. “Maximum Entropy Models as a Tool for Building
    Precise Neural Controls.” <i>Current Opinion in Neurobiology</i>, vol. 46, Elsevier,
    2017, pp. 120–26, doi:<a href="https://doi.org/10.1016/j.conb.2017.08.001">10.1016/j.conb.2017.08.001</a>.
  short: C. Savin, G. Tkačik, Current Opinion in Neurobiology 46 (2017) 120–126.
date_created: 2018-12-11T11:48:11Z
date_published: 2017-10-01T00:00:00Z
date_updated: 2026-04-16T10:04:15Z
day: '01'
department:
- _id: GaTk
doi: 10.1016/j.conb.2017.08.001
ec_funded: 1
external_id:
  isi:
  - '000416196400016'
intvolume: '        46'
isi: 1
language:
- iso: eng
month: '10'
oa_version: None
page: 120 - 126
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
  call_identifier: FP7
  grant_number: '291734'
  name: International IST Postdoc Fellowship Programme
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '6943'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Maximum entropy models as a tool for building precise neural controls
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 46
year: '2017'
...
---
_id: '7699'
article_processing_charge: No
article_type: original
author:
- first_name: Lora Beatrice Jaeger
  full_name: Sweeney, Lora Beatrice Jaeger
  id: 56BE8254-C4F0-11E9-8E45-0B23E6697425
  last_name: Sweeney
  orcid: 0000-0001-9242-5601
- first_name: Darcy B
  full_name: Kelley, Darcy B
  last_name: Kelley
citation:
  ama: Sweeney LB, Kelley DB. Harnessing vocal patterns for social communication.
    <i>Current Opinion in Neurobiology</i>. 2014;28(10):34-41. doi:<a href="https://doi.org/10.1016/j.conb.2014.06.006">10.1016/j.conb.2014.06.006</a>
  apa: Sweeney, L. B., &#38; Kelley, D. B. (2014). Harnessing vocal patterns for social
    communication. <i>Current Opinion in Neurobiology</i>. Elsevier. <a href="https://doi.org/10.1016/j.conb.2014.06.006">https://doi.org/10.1016/j.conb.2014.06.006</a>
  chicago: Sweeney, Lora B., and Darcy B Kelley. “Harnessing Vocal Patterns for Social
    Communication.” <i>Current Opinion in Neurobiology</i>. Elsevier, 2014. <a href="https://doi.org/10.1016/j.conb.2014.06.006">https://doi.org/10.1016/j.conb.2014.06.006</a>.
  ieee: L. B. Sweeney and D. B. Kelley, “Harnessing vocal patterns for social communication,”
    <i>Current Opinion in Neurobiology</i>, vol. 28, no. 10. Elsevier, pp. 34–41,
    2014.
  ista: Sweeney LB, Kelley DB. 2014. Harnessing vocal patterns for social communication.
    Current Opinion in Neurobiology. 28(10), 34–41.
  mla: Sweeney, Lora B., and Darcy B. Kelley. “Harnessing Vocal Patterns for Social
    Communication.” <i>Current Opinion in Neurobiology</i>, vol. 28, no. 10, Elsevier,
    2014, pp. 34–41, doi:<a href="https://doi.org/10.1016/j.conb.2014.06.006">10.1016/j.conb.2014.06.006</a>.
  short: L.B. Sweeney, D.B. Kelley, Current Opinion in Neurobiology 28 (2014) 34–41.
date_created: 2020-04-30T10:35:39Z
date_published: 2014-10-01T00:00:00Z
date_updated: 2024-01-31T10:14:08Z
day: '01'
doi: 10.1016/j.conb.2014.06.006
extern: '1'
intvolume: '        28'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 34-41
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: Harnessing vocal patterns for social communication
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2014'
...
---
OA_type: closed access
_id: '3139'
article_processing_charge: No
author:
- first_name: Hsiao
  full_name: Chen, Hsiao
  last_name: Chen
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Silvia
  full_name: Arber, Silvia
  last_name: Arber
- first_name: Eric
  full_name: Frank, Eric
  last_name: Frank
citation:
  ama: Chen H, Hippenmeyer S, Arber S, Frank E. Development of the monosynaptic stretch
    reflex circuit. <i>Current Opinion in Neurobiology</i>. 2003;13(1):96-102. doi:<a
    href="https://doi.org/10.1016/S0959-4388(03)00006-0">10.1016/S0959-4388(03)00006-0</a>
  apa: Chen, H., Hippenmeyer, S., Arber, S., &#38; Frank, E. (2003). Development of
    the monosynaptic stretch reflex circuit. <i>Current Opinion in Neurobiology</i>.
    Elsevier. <a href="https://doi.org/10.1016/S0959-4388(03)00006-0">https://doi.org/10.1016/S0959-4388(03)00006-0</a>
  chicago: Chen, Hsiao, Simon Hippenmeyer, Silvia Arber, and Eric Frank. “Development
    of the Monosynaptic Stretch Reflex Circuit.” <i>Current Opinion in Neurobiology</i>.
    Elsevier, 2003. <a href="https://doi.org/10.1016/S0959-4388(03)00006-0">https://doi.org/10.1016/S0959-4388(03)00006-0</a>.
  ieee: H. Chen, S. Hippenmeyer, S. Arber, and E. Frank, “Development of the monosynaptic
    stretch reflex circuit,” <i>Current Opinion in Neurobiology</i>, vol. 13, no.
    1. Elsevier, pp. 96–102, 2003.
  ista: Chen H, Hippenmeyer S, Arber S, Frank E. 2003. Development of the monosynaptic
    stretch reflex circuit. Current Opinion in Neurobiology. 13(1), 96–102.
  mla: Chen, Hsiao, et al. “Development of the Monosynaptic Stretch Reflex Circuit.”
    <i>Current Opinion in Neurobiology</i>, vol. 13, no. 1, Elsevier, 2003, pp. 96–102,
    doi:<a href="https://doi.org/10.1016/S0959-4388(03)00006-0">10.1016/S0959-4388(03)00006-0</a>.
  short: H. Chen, S. Hippenmeyer, S. Arber, E. Frank, Current Opinion in Neurobiology
    13 (2003) 96–102.
date_created: 2018-12-11T12:01:37Z
date_published: 2003-02-01T00:00:00Z
date_updated: 2026-05-22T08:40:52Z
day: '01'
doi: 10.1016/S0959-4388(03)00006-0
extern: '1'
external_id:
  pmid:
  - '12593987'
intvolume: '        13'
issue: '1'
language:
- iso: eng
month: '02'
oa_version: None
page: 96 - 102
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
  eissn:
  - 1873-6882
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '3557'
status: public
title: Development of the monosynaptic stretch reflex circuit
type: review
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 13
year: '2003'
...
---
_id: '3460'
abstract:
- lang: eng
  text: Excitatory postsynaptic currents in neurones of the central nervous system
    have a dual-component time course that results from the co-activation of AMPA/kainate-type
    and NMDA-type glutamate receptors. New approaches in electrophysiology and molecular
    biology have provided a better understanding of the factors that determine the
    kinectics of excitatory postsynaptic currents. Recent studies suggest that the
    time course of neurotransmitter concentration in the synaptic cleft, the gating
    properties of the native channels, and the glutamate receptor subunit composition
    all appear to be important factors.
acknowledgement: 'We thank JGG Borst, N Burnashev, M Häusser, G Stuart and A Viilarroel
  for critically reading the manuscript and E von Kitzing and A Roth for doing the
  simulations and for many helpful discussions. Supported by the Deutsche Forschungsgemeinschaft
  (SFB 317-B14) and the Alexander von Humboldt Foundation. '
article_processing_charge: No
article_type: original
author:
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
- first_name: Nelson
  full_name: Spruston, Nelson
  last_name: Spruston
citation:
  ama: Jonas PM, Spruston N. Mechanisms shaping glutamate-mediated excitatory postsynaptic
    currents in the CNS. <i>Current Opinion in Neurobiology</i>. 1994;4(3):366-372.
    doi:<a href="https://doi.org/10.1016/0959-4388(94)90098-1">10.1016/0959-4388(94)90098-1</a>
  apa: Jonas, P. M., &#38; Spruston, N. (1994). Mechanisms shaping glutamate-mediated
    excitatory postsynaptic currents in the CNS. <i>Current Opinion in Neurobiology</i>.
    Elsevier. <a href="https://doi.org/10.1016/0959-4388(94)90098-1">https://doi.org/10.1016/0959-4388(94)90098-1</a>
  chicago: Jonas, Peter M, and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
    Excitatory Postsynaptic Currents in the CNS.” <i>Current Opinion in Neurobiology</i>.
    Elsevier, 1994. <a href="https://doi.org/10.1016/0959-4388(94)90098-1">https://doi.org/10.1016/0959-4388(94)90098-1</a>.
  ieee: P. M. Jonas and N. Spruston, “Mechanisms shaping glutamate-mediated excitatory
    postsynaptic currents in the CNS,” <i>Current Opinion in Neurobiology</i>, vol.
    4, no. 3. Elsevier, pp. 366–372, 1994.
  ista: Jonas PM, Spruston N. 1994. Mechanisms shaping glutamate-mediated excitatory
    postsynaptic currents in the CNS. Current Opinion in Neurobiology. 4(3), 366–372.
  mla: Jonas, Peter M., and Nelson Spruston. “Mechanisms Shaping Glutamate-Mediated
    Excitatory Postsynaptic Currents in the CNS.” <i>Current Opinion in Neurobiology</i>,
    vol. 4, no. 3, Elsevier, 1994, pp. 366–72, doi:<a href="https://doi.org/10.1016/0959-4388(94)90098-1">10.1016/0959-4388(94)90098-1</a>.
  short: P.M. Jonas, N. Spruston, Current Opinion in Neurobiology 4 (1994) 366–372.
date_created: 2018-12-11T12:03:27Z
date_published: 1994-06-01T00:00:00Z
date_updated: 2022-06-03T11:26:52Z
day: '01'
doi: 10.1016/0959-4388(94)90098-1
extern: '1'
external_id:
  pmid:
  - '7522678 '
intvolume: '         4'
issue: '3'
language:
- iso: eng
main_file_link:
- url: https://www.sciencedirect.com/science/article/pii/0959438894900981?via%3Dihub
month: '06'
oa_version: None
page: 366 - 372
pmid: 1
publication: Current Opinion in Neurobiology
publication_identifier:
  issn:
  - 0959-4388
publication_status: published
publisher: Elsevier
publist_id: '2927'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanisms shaping glutamate-mediated excitatory postsynaptic currents in the
  CNS
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 4
year: '1994'
...