---
OA_type: closed access
_id: '2626'
abstract:
- lang: eng
text: The expression pattern of metabotropic glutamate receptor Iα (mGluR1α) was
immunohistochemically investigated in substantia nigra dopaminergic neurons of
the macaque monkey. In normal monkeys, mGluR1α immunoreactivity was weakly observed
in the dorsal tier of the substantia nigra pars compacta (SNc-d) where calbindin-D28k-containing
dopaminergic neurons invulnerable to parkinsonian degeneration are specifically
located. On the other hand, mGluR1α was strongly expressed in the ventral tier
of the substantia nigra pars cornpacta (SNc-v). In monkeys treated with the parkinsonism-inducing
drug, I-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), mGluR1α expression
was decreased in dopaminergic neurons in the SNc-v that were spared its toxic
action. These results suggest that mGluR1α expression may be involved at least
partly in the vulnerability of dopaminergic neurons to parkinsonian insults.
article_processing_charge: No
article_type: original
author:
- first_name: Katsuyuki
full_name: Kaneda, Katsuyuki
last_name: Kaneda
- first_name: Michiko
full_name: Imanishi, Michiko
last_name: Imanishi
- first_name: Atsushi
full_name: Nambu, Atsushi
last_name: Nambu
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Masahiko
full_name: Takada, Masahiko
last_name: Takada
citation:
ama: Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M. Differential expression
patterns of mGluR1α in monkey nigral dopamine neurons. Neuroreport. 2003;14(7):947-950.
doi:10.1097/01.wnr.0000074344.81633.e4
apa: Kaneda, K., Imanishi, M., Nambu, A., Shigemoto, R., & Takada, M. (2003).
Differential expression patterns of mGluR1α in monkey nigral dopamine neurons.
Neuroreport. Lippincott Williams & Wilkins. https://doi.org/10.1097/01.wnr.0000074344.81633.e4
chicago: Kaneda, Katsuyuki, Michiko Imanishi, Atsushi Nambu, Ryuichi Shigemoto,
and Masahiko Takada. “Differential Expression Patterns of MGluR1α in Monkey Nigral
Dopamine Neurons.” Neuroreport. Lippincott Williams & Wilkins, 2003.
https://doi.org/10.1097/01.wnr.0000074344.81633.e4.
ieee: K. Kaneda, M. Imanishi, A. Nambu, R. Shigemoto, and M. Takada, “Differential
expression patterns of mGluR1α in monkey nigral dopamine neurons,” Neuroreport,
vol. 14, no. 7. Lippincott Williams & Wilkins, pp. 947–950, 2003.
ista: Kaneda K, Imanishi M, Nambu A, Shigemoto R, Takada M. 2003. Differential expression
patterns of mGluR1α in monkey nigral dopamine neurons. Neuroreport. 14(7), 947–950.
mla: Kaneda, Katsuyuki, et al. “Differential Expression Patterns of MGluR1α in Monkey
Nigral Dopamine Neurons.” Neuroreport, vol. 14, no. 7, Lippincott Williams
& Wilkins, 2003, pp. 947–50, doi:10.1097/01.wnr.0000074344.81633.e4.
short: K. Kaneda, M. Imanishi, A. Nambu, R. Shigemoto, M. Takada, Neuroreport 14
(2003) 947–950.
date_created: 2018-12-11T11:58:45Z
date_published: 2003-05-01T00:00:00Z
date_updated: 2026-05-27T06:31:08Z
day: '01'
doi: 10.1097/01.wnr.0000074344.81633.e4
extern: '1'
external_id:
pmid:
- '12802180'
fulldoi: https://doi.org/10.1097/01.wnr.0000074344.81633.e4
intvolume: ' 14'
issue: '7'
language:
- iso: eng
month: '05'
oa_version: None
page: 947 - 950
pmid: 1
publication: Neuroreport
publication_identifier:
eissn:
- 1473-558X
issn:
- 0959-4965
publication_status: published
publisher: Lippincott Williams & Wilkins
publist_id: '4272'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Differential expression patterns of mGluR1α in monkey nigral dopamine neurons
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 14
year: '2003'
...
---
_id: '4202'
abstract:
- lang: eng
text: NERVE growth factor (NGF) injected into the otherwise unlesioned adult rat
septum induced sprouting of presumptive cholinergic fibres positive for p75(NGFR)
and acetylcholinesterase (AChE). These fibres did not stain for tyrosine hydroxylase
and therefore did not represent sympathetic ingrowth. Neurofilament staining on
adjacent sections revealed fibres with similar morphology, suggesting new outgrowth
in the form of sprouting rather than the upregulation of p75(NGFR) and AChE in
pre-existing fibres. Simultaneous injections of subneurotoxic doses of N-methyl-D-aspartate
(NMDA) significantly potentiated the effect of NGF on cholinergic fibre sprouting
and caused pronounced glial fibrillary acidic protein (GFAP)positive astrocytosis.
Application of NMDA alone did not elicit sprouting of this type. These findings
indicate that NGF can induce the sprouting of uninjured adult rat septal cholinergic
fibres in vivo and suggest that reactive astrocytes are not inhibitory to cholinergic
axonal outgrowth, and might serve as a substrate for growing axons in the presence
of NGF.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: John
full_name: Cooper, John
last_name: Cooper
- first_name: J
full_name: Berke, J
last_name: Berke
- first_name: Michael
full_name: Sofroniew, Michael
last_name: Sofroniew
citation:
ama: Heisenberg C-PJ, Cooper J, Berke J, Sofroniew M. NMDA potentiates NGF-induced
sprouting of septal cholinergic fibres. Neuroreport. 1994;5(4):413-416.
doi:10.1097/00001756-199401120-00010
apa: Heisenberg, C.-P. J., Cooper, J., Berke, J., & Sofroniew, M. (1994). NMDA
potentiates NGF-induced sprouting of septal cholinergic fibres. Neuroreport.
Lippincott, Williams & Wilkins. https://doi.org/10.1097/00001756-199401120-00010
chicago: Heisenberg, Carl-Philipp J, John Cooper, J Berke, and Michael Sofroniew.
“NMDA Potentiates NGF-Induced Sprouting of Septal Cholinergic Fibres.” Neuroreport.
Lippincott, Williams & Wilkins, 1994. https://doi.org/10.1097/00001756-199401120-00010 .
ieee: C.-P. J. Heisenberg, J. Cooper, J. Berke, and M. Sofroniew, “NMDA potentiates
NGF-induced sprouting of septal cholinergic fibres,” Neuroreport, vol.
5, no. 4. Lippincott, Williams & Wilkins, pp. 413–416, 1994.
ista: Heisenberg C-PJ, Cooper J, Berke J, Sofroniew M. 1994. NMDA potentiates NGF-induced
sprouting of septal cholinergic fibres. Neuroreport. 5(4), 413–416.
mla: Heisenberg, Carl-Philipp J., et al. “NMDA Potentiates NGF-Induced Sprouting
of Septal Cholinergic Fibres.” Neuroreport, vol. 5, no. 4, Lippincott,
Williams & Wilkins, 1994, pp. 413–16, doi:10.1097/00001756-199401120-00010 .
short: C.-P.J. Heisenberg, J. Cooper, J. Berke, M. Sofroniew, Neuroreport 5 (1994)
413–416.
date_created: 2018-12-11T12:07:33Z
date_published: 1994-01-12T00:00:00Z
date_updated: 2022-06-02T10:07:25Z
day: '12'
doi: '10.1097/00001756-199401120-00010 '
extern: '1'
fulldoi: 'https://doi.org/10.1097/00001756-199401120-00010 '
intvolume: ' 5'
issue: '4'
language:
- iso: eng
main_file_link:
- url: https://journals.lww.com/neuroreport/Abstract/1994/01120/NMDA_potentiates_NGF_induced_sprouting_of_septal.10.aspx
month: '01'
oa_version: None
page: 413 - 416
publication: Neuroreport
publication_identifier:
issn:
- 0959-4965
publication_status: published
publisher: Lippincott, Williams & Wilkins
publist_id: '1915'
quality_controlled: '1'
scopus_import: '1'
status: public
title: NMDA potentiates NGF-induced sprouting of septal cholinergic fibres
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 5
year: '1994'
...
---
_id: '4195'
abstract:
- lang: eng
text: The effects of tri-iodothyronine (T3), which are known to affect cerebellar
development, were tested on neuronal survival and differentiation of cultured
cerebellar granule neurons. T3 in physiological concentrations increased both
granule neuron survival after three days in culture and synaptic vesicle protein
formation, as shown by immunostaining with antibodies against synaptophysin. Likewise,
T3 increased the mRNA level for synapsin(I), but not that for GAP43 in granule
neurons. Antibodies against microtubule associated protein Tau, which is expressed
in developing neurites, showed that T3 also enhanced neurite formation.
article_processing_charge: No
article_type: original
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
- first_name: Hans
full_name: Thoenen, Hans
last_name: Thoenen
- first_name: Dan
full_name: Lindholm, Dan
last_name: Lindholm
citation:
ama: Heisenberg C-PJ, Thoenen H, Lindholm D. Triiodothyronine Regulates Survival
and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport. 1992;3(8):685-688.
doi:10.1097/00001756-199208000-00008
apa: Heisenberg, C.-P. J., Thoenen, H., & Lindholm, D. (1992). Triiodothyronine
Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport.
Lippincott, Williams & Wilkins. https://doi.org/10.1097/00001756-199208000-00008
chicago: Heisenberg, Carl-Philipp J, Hans Thoenen, and Dan Lindholm. “Triiodothyronine
Regulates Survival and Differentiation of Rat Cerebellar Granule Neurons.” Neuroreport.
Lippincott, Williams & Wilkins, 1992. https://doi.org/10.1097/00001756-199208000-00008 .
ieee: C.-P. J. Heisenberg, H. Thoenen, and D. Lindholm, “Triiodothyronine Regulates
Survival and Differentiation of Rat Cerebellar Granule Neurons,” Neuroreport,
vol. 3, no. 8. Lippincott, Williams & Wilkins, pp. 685–688, 1992.
ista: Heisenberg C-PJ, Thoenen H, Lindholm D. 1992. Triiodothyronine Regulates Survival
and Differentiation of Rat Cerebellar Granule Neurons. Neuroreport. 3(8), 685–688.
mla: Heisenberg, Carl-Philipp J., et al. “Triiodothyronine Regulates Survival and
Differentiation of Rat Cerebellar Granule Neurons.” Neuroreport, vol. 3,
no. 8, Lippincott, Williams & Wilkins, 1992, pp. 685–88, doi:10.1097/00001756-199208000-00008 .
short: C.-P.J. Heisenberg, H. Thoenen, D. Lindholm, Neuroreport 3 (1992) 685–688.
date_created: 2018-12-11T12:07:31Z
date_published: 1992-01-01T00:00:00Z
date_updated: 2022-03-15T15:25:24Z
day: '01'
doi: '10.1097/00001756-199208000-00008 '
extern: '1'
external_id:
pmid:
- '1387811 '
fulldoi: 'https://doi.org/10.1097/00001756-199208000-00008 '
intvolume: ' 3'
issue: '8'
language:
- iso: eng
main_file_link:
- url: https://journals.lww.com/neuroreport/abstract/1992/08000/tri_iodothyronine_regulates_survival_and.8.aspx
month: '01'
oa_version: None
page: 685 - 688
pmid: 1
publication: Neuroreport
publication_identifier:
eissn:
- 1473-558X
issn:
- 0959-4965
publication_status: published
publisher: Lippincott, Williams & Wilkins
publist_id: '1922'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Triiodothyronine Regulates Survival and Differentiation of Rat Cerebellar Granule
Neurons
type: journal_article
user_id: ea97e931-d5af-11eb-85d4-e6957dddbf17
volume: 3
year: '1992'
...