[{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"letter_note","author":[{"full_name":"Kücükdereli, Hakan","id":"5d5f6ea4-ef9e-11f0-a10a-85e12a3552af","first_name":"Hakan","last_name":"Kücükdereli"},{"first_name":"Amelia May Barnett","full_name":"Douglass, Amelia May Barnett","id":"de5f6fda-80fb-11ef-996f-a8c4ecd8e289","orcid":"0000-0001-5398-6473","last_name":"Douglass"}],"OA_type":"closed access","date_published":"2026-01-05T00:00:00Z","abstract":[{"lang":"eng","text":"Small amounts of stress are thought to have beneficial effects. A new study reports a mechanism by which the psychedelic drug, psilocybin, causes acute release of stress hormones, despite its known long-term anti-anxiety effects."}],"scopus_import":"1","status":"public","pmid":1,"month":"01","article_processing_charge":"No","title":"Neuroscience: What doesn’t kill you makes you stronger","year":"2026","issue":"1","_id":"20972","oa_version":"None","date_created":"2026-01-11T23:01:33Z","department":[{"_id":"AmDo"},{"_id":"SiHi"}],"date_updated":"2026-01-12T10:09:13Z","external_id":{"pmid":["41494523"]},"corr_author":"1","intvolume":"        36","quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"publication":"Current Biology","page":"R27-R29","day":"05","publisher":"Elsevier","doi":"10.1016/j.cub.2025.11.056","type":"journal_article","citation":{"chicago":"Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” <i>Current Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">https://doi.org/10.1016/j.cub.2025.11.056</a>.","ama":"Kücükdereli H, Douglass AM. Neuroscience: What doesn’t kill you makes you stronger. <i>Current Biology</i>. 2026;36(1):R27-R29. doi:<a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">10.1016/j.cub.2025.11.056</a>","ieee":"H. Kücükdereli and A. M. Douglass, “Neuroscience: What doesn’t kill you makes you stronger,” <i>Current Biology</i>, vol. 36, no. 1. Elsevier, pp. R27–R29, 2026.","mla":"Kücükdereli, Hakan, and Amelia M. Douglass. “Neuroscience: What Doesn’t Kill You Makes You Stronger.” <i>Current Biology</i>, vol. 36, no. 1, Elsevier, 2026, pp. R27–29, doi:<a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">10.1016/j.cub.2025.11.056</a>.","apa":"Kücükdereli, H., &#38; Douglass, A. M. (2026). Neuroscience: What doesn’t kill you makes you stronger. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2025.11.056\">https://doi.org/10.1016/j.cub.2025.11.056</a>","ista":"Kücükdereli H, Douglass AM. 2026. Neuroscience: What doesn’t kill you makes you stronger. Current Biology. 36(1), R27–R29.","short":"H. Kücükdereli, A.M. Douglass, Current Biology 36 (2026) R27–R29."},"volume":36},{"quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"OA_place":"publisher","has_accepted_license":"1","date_updated":"2026-01-20T07:33:32Z","date_created":"2026-01-14T12:00:29Z","department":[{"_id":"GradSch"},{"_id":"TiVo"}],"PlanS_conform":"1","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"citation":{"ista":"Calderon Garcia JS, Costalunga G, Vogels TP, Vallentin D. 2026. Interplay between syllable duration and pitch during whistle matching in wild nightingales. Current Biology.","apa":"Calderon Garcia, J. S., Costalunga, G., Vogels, T. P., &#38; Vallentin, D. (2026). Interplay between syllable duration and pitch during whistle matching in wild nightingales. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2025.12.025\">https://doi.org/10.1016/j.cub.2025.12.025</a>","mla":"Calderon Garcia, Juan Sebastian, et al. “Interplay between Syllable Duration and Pitch during Whistle Matching in Wild Nightingales.” <i>Current Biology</i>, Elsevier, 2026, doi:<a href=\"https://doi.org/10.1016/j.cub.2025.12.025\">10.1016/j.cub.2025.12.025</a>.","ieee":"J. S. Calderon Garcia, G. Costalunga, T. P. Vogels, and D. Vallentin, “Interplay between syllable duration and pitch during whistle matching in wild nightingales,” <i>Current Biology</i>. Elsevier, 2026.","short":"J.S. Calderon Garcia, G. Costalunga, T.P. Vogels, D. Vallentin, Current Biology (2026).","chicago":"Calderon Garcia, Juan Sebastian, Giacomo Costalunga, Tim P Vogels, and Daniela Vallentin. “Interplay between Syllable Duration and Pitch during Whistle Matching in Wild Nightingales.” <i>Current Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cub.2025.12.025\">https://doi.org/10.1016/j.cub.2025.12.025</a>.","ama":"Calderon Garcia JS, Costalunga G, Vogels TP, Vallentin D. Interplay between syllable duration and pitch during whistle matching in wild nightingales. <i>Current Biology</i>. 2026. doi:<a href=\"https://doi.org/10.1016/j.cub.2025.12.025\">10.1016/j.cub.2025.12.025</a>"},"doi":"10.1016/j.cub.2025.12.025","day":"12","publisher":"Elsevier","ec_funded":1,"type":"journal_article","publication":"Current Biology","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cub.2025.12.025"}],"date_published":"2026-01-12T00:00:00Z","abstract":[{"lang":"eng","text":"During complex vocal interactions, different features of acoustic stimuli are integrated to produce appropriate vocal responses,1 such as copying sounds during vocal matching behavior in some animals.2,3,4,5,6,7,8,9,10,11,12 However, little is known about the interplay and possible trade-offs between the different temporal and spectral acoustic features during these vocal exchanges.2,13,14 Nightingales can flexibly match the pitch of their tonal “whistle songs” in real time during counter-singing duels.15,16 Here, we show that the syllable duration of whistle playbacks could alter the song responses of wild nightingales, causing their whistle duration distribution to shift toward the presented stimulus duration. When exposed to whistle playbacks featuring unnatural combinations of pitch and duration, nightingales demonstrate a flexible trade-off between pitch matching and temporal imitation, yet they are constrained by their vocal repertoire. They selectively adapted their vocal responses to approximate these novel stimuli, aligning them with their natural whistle repertoire. We developed a computational model of nightingale whistle-matching behavior that revealed a hierarchical organization of acoustic feature production. During whistle matching, the feature integration process is constrained by the duration of syllables, and pitch matching follows within this temporal framework, forcing a trade-off between the two features. Our findings reveal a complex interplay between the spectral and temporal domains that shapes song-matching behavior."}],"scopus_import":"1","status":"public","OA_type":"hybrid","ddc":["570","577"],"acknowledgement":"We would like to thank J. Benichov and N. Hein for their help with fieldwork; M. Ramadas for helping with the segmentation analysis; T. Eliav, C. Chintaluri, G. Tkacik, and A. Navas for providing helpful comments to the project and manuscript; and A. Costalunga for the drawings of nightingales. Funding sources: The Joachim Herz Stiftung Add-on Fellowships for Interdisciplinary Life Science, awarded to G.C.; the ERC Consolidator Grant 819603 SYNAPSEEK, awarded to T.P.V.; and DFG Research Unit 5768–532521431, DFG Research Grant-547921981, DFG SFB 1315–327654276, and the ERC Starting Grant 757459 MIDNIGHT, awarded to D.V.","article_type":"original","publication_status":"epub_ahead","project":[{"name":"Learning the shape of synaptic plasticity rules for neuronal architectures and function through machine learning.","call_identifier":"H2020","grant_number":"819603","_id":"0aacfa84-070f-11eb-9043-d7eb2c709234"}],"author":[{"first_name":"Juan Sebastian","id":"1271b54b-dbcd-11ea-9d1d-d92da838fe2c","full_name":"Calderon Garcia, Juan Sebastian","last_name":"Calderon Garcia"},{"first_name":"Giacomo","full_name":"Costalunga, Giacomo","last_name":"Costalunga"},{"first_name":"Tim P","full_name":"Vogels, Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels","orcid":"0000-0003-3295-6181"},{"full_name":"Vallentin, Daniela","first_name":"Daniela","last_name":"Vallentin"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"_id":"20986","year":"2026","oa_version":"Published Version","title":"Interplay between syllable duration and pitch during whistle matching in wild nightingales","article_processing_charge":"Yes (in subscription journal)","month":"01"},{"OA_type":"hybrid","ddc":["580"],"acknowledgement":"We thank Dr. Z. Ge (ISTA) for providing vectors for the CRISPR-Cas9 system, Dr. Armel Nicolas and Dr. Bella Bruszel for phosphoproteomic analysis, Prof. Michael Wrzaczek (Czech Academy of Sciences, Czechia) for valuable suggestions, and Prof. Maciek Adamowski (University of Gdańsk) for technical assistance. We also acknowledge the support of the Mass Spectrometry and Proteomics Facility, the Imaging & Optics Facility, and the Lab Support Facility at the Institute of Science and Technology Austria. This research was supported by the Scientific Service Units (SSU) of ISTA, utilizing resources provided by the Imaging & Optics Facility (IOF) and the Lab Support Facility (LSF). The work conducted by the Friml group was funded by the European Research Council (ERC) under grant agreement no. 101142681 (CYNIPS) and by the Austrian Science Fund (FWF) under project ESP271. We acknowledge the core facility CELLIM supported by MEYS CR (LM2023050 Czech-BioImaging) and the Plant Sciences Core Facility of CEITEC Masaryk University. E.M. received support from the National Science Centre (NCN), Poland, through the OPUS call within the Weave programme (grant no. 2021/43/I/NZ1/01835). T.N. received support from TowArds Next GENeration Crops, reg. no. CZ.02.01.01/00/22_008/0004581 of the ERDF Programme Johannes Amos Comenius.","abstract":[{"lang":"eng","text":"Auxin canalization is a self-organizing process that governs the flexible formation of vasculature by reinforcing the formation of auxin transport channels. A key prerequisite is the feedback between auxin signaling and directional auxin transport, mediated by PIN transporters. Despite the developmental importance of canalization, the molecular components linking auxin perception to the regulation of PIN auxin transporters remain poorly understood. Here, we identify TOW, a novel and essential component of auxin canalization that links intracellular auxin signaling with cell surface auxin perception. TOW is regulated downstream of TIR1/AFB-Aux/IAA-WRKY23 transcriptional auxin signaling. tow mutants exhibit defects in regeneration and de novo vasculature formation, along with impaired formation of polarized, PIN-expressing auxin channels. At the subcellular level, these mutants display disrupted auxin-induced PIN polarization and altered PIN endocytic trafficking dynamics. TOW localizes predominantly to the plasma membrane, where it interacts with receptor-like kinases involved in auxin canalization, including the TMK1 auxin co-receptor and the CAMEL-CANAR complex. TOW promotes PIN interaction with these kinases and stabilizes PINs at the cell surface. Together, our findings identify TOW as a molecular link between intracellular and cell surface auxin signaling mechanisms that converge on PIN trafficking and polarity, providing new insights into how auxin signaling regulates directional auxin transport for the self-organizing formation of vasculature during flexible plant development."}],"date_published":"2026-03-23T00:00:00Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"content_type":"application/pdf","access_level":"open_access","creator":"dernst","date_created":"2026-03-24T08:34:37Z","file_id":"21496","relation":"main_file","file_size":12986894,"success":1,"checksum":"fe6c41fdab58a55df5f2a5860c02acdc","date_updated":"2026-03-24T08:34:37Z","file_name":"2026_CurrentBiology_Li.pdf"}],"oa":1,"article_type":"original","publication_status":"published","project":[{"name":"Cyclic nucleotides as second messengers in plants","grant_number":"101142681","_id":"8f347782-16d5-11f0-9cad-8c19706ee739"},{"_id":"bd906599-d553-11ed-ba76-abf8547645d7","grant_number":"E271","name":"Identification of a novel regulator in auxin canalization"}],"author":[{"first_name":"Mingyue","full_name":"Li, Mingyue","id":"01f96916-0235-11eb-9379-a323192643b7","last_name":"Li"},{"full_name":"Rydza, Nikola","first_name":"Nikola","last_name":"Rydza"},{"last_name":"Mazur","first_name":"Ewa","full_name":"Mazur, Ewa"},{"id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","full_name":"Molnar, Gergely","first_name":"Gergely","last_name":"Molnar"},{"full_name":"Nodzyński, Tomasz","first_name":"Tomasz","last_name":"Nodzyński"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","first_name":"Jiří","last_name":"Friml","orcid":"0000-0002-8302-7596"}],"title":"Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization","_id":"21490","issue":"6","year":"2026","oa_version":"Published Version","pmid":1,"month":"03","article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","OA_place":"publisher","date_updated":"2026-03-24T08:36:40Z","corr_author":"1","external_id":{"pmid":["41831441"]},"language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"        36","publication_identifier":{"issn":["0960-9822"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"acknowledged_ssus":[{"_id":"MassSpec"},{"_id":"Bio"},{"_id":"LifeSc"}],"file_date_updated":"2026-03-24T08:34:37Z","date_created":"2026-03-23T15:11:16Z","PlanS_conform":"1","department":[{"_id":"JiFr"}],"day":"23","publisher":"Elsevier","doi":"10.1016/j.cub.2026.02.023","page":"1468-1480.e6","type":"journal_article","citation":{"ama":"Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. <i>Current Biology</i>. 2026;36(6):1468-1480.e6. doi:<a href=\"https://doi.org/10.1016/j.cub.2026.02.023\">10.1016/j.cub.2026.02.023</a>","chicago":"Li, Mingyue, Nikola Rydza, Ewa Mazur, Gergely Molnar, Tomasz Nodzyński, and Jiří Friml. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” <i>Current Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cub.2026.02.023\">https://doi.org/10.1016/j.cub.2026.02.023</a>.","short":"M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, J. Friml, Current Biology 36 (2026) 1468–1480.e6.","ieee":"M. Li, N. Rydza, E. Mazur, G. Molnar, T. Nodzyński, and J. Friml, “Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization,” <i>Current Biology</i>, vol. 36, no. 6. Elsevier, p. 1468–1480.e6, 2026.","ista":"Li M, Rydza N, Mazur E, Molnar G, Nodzyński T, Friml J. 2026. Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. Current Biology. 36(6), 1468–1480.e6.","mla":"Li, Mingyue, et al. “Receptor-like-Kinase-Interacting Protein TOW Stabilizes PIN Transporters for Auxin Canalization.” <i>Current Biology</i>, vol. 36, no. 6, Elsevier, 2026, p. 1468–1480.e6, doi:<a href=\"https://doi.org/10.1016/j.cub.2026.02.023\">10.1016/j.cub.2026.02.023</a>.","apa":"Li, M., Rydza, N., Mazur, E., Molnar, G., Nodzyński, T., &#38; Friml, J. (2026). Receptor-like-kinase-interacting protein TOW stabilizes PIN transporters for auxin canalization. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2026.02.023\">https://doi.org/10.1016/j.cub.2026.02.023</a>"},"volume":36,"publication":"Current Biology"},{"doi":"10.1016/j.cub.2026.02.068","day":"20","publisher":"Elsevier","page":"1903-1917.e5","type":"journal_article","citation":{"ama":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. <i>Current Biology</i>. 2026;36(8):1903-1917.e5. doi:<a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">10.1016/j.cub.2026.02.068</a>","chicago":"Perez Verdugo, Fernanda L, Eirini Maniou, Gabriel L. Galea, and Shiladitya Banerjee. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” <i>Current Biology</i>. Elsevier, 2026. <a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">https://doi.org/10.1016/j.cub.2026.02.068</a>.","short":"F.L. Perez Verdugo, E. Maniou, G.L. Galea, S. Banerjee, Current Biology 36 (2026) 1903–1917.e5.","mla":"Perez Verdugo, Fernanda L., et al. “Mechanosensitive Feedback Organizes Cell Shape and Motion during Hindbrain Neuropore Morphogenesis.” <i>Current Biology</i>, vol. 36, no. 8, Elsevier, 2026, p. 1903–1917.e5, doi:<a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">10.1016/j.cub.2026.02.068</a>.","apa":"Perez Verdugo, F. L., Maniou, E., Galea, G. L., &#38; Banerjee, S. (2026). Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2026.02.068\">https://doi.org/10.1016/j.cub.2026.02.068</a>","ista":"Perez Verdugo FL, Maniou E, Galea GL, Banerjee S. 2026. Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis. Current Biology. 36(8), 1903–1917.e5.","ieee":"F. L. Perez Verdugo, E. Maniou, G. L. Galea, and S. Banerjee, “Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis,” <i>Current Biology</i>, vol. 36, no. 8. Elsevier, p. 1903–1917.e5, 2026."},"volume":36,"publication":"Current Biology","OA_place":"publisher","has_accepted_license":"1","date_updated":"2026-04-28T13:15:42Z","external_id":{"pmid":["41881011"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        36","publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","short":"CC BY-NC-ND (4.0)"},"date_created":"2026-04-26T22:01:46Z","file_date_updated":"2026-04-28T13:13:40Z","department":[{"_id":"AnSa"}],"title":"Mechanosensitive feedback organizes cell shape and motion during hindbrain neuropore morphogenesis","_id":"21761","issue":"8","year":"2026","oa_version":"Published Version","pmid":1,"month":"04","article_processing_charge":"Yes (in subscription journal)","OA_type":"hybrid","ddc":["570"],"acknowledgement":"S.B. acknowledges support from the National Institutes of Health (NIH R35 GM143042) and the National Science Foundation (NSF MCB-2203601). G.L.G. acknowledges support from the Wellcome Trust (211112/Z/18/Z), the Royal Society (RG\\R2\\232082), and the Leverhulme Trust (RPG-2024-147). E.M. acknowledges support from European Union’s Horizon 2021 Marie Sklodowska-Curie grant agreement no. 101067028. F.P.-V. acknowledges support from the NOMIS foundation. The surface subtraction macro is courtesy of Dr. Dale Moulding and available on GitHub (https://github.com/DaleMoulding/Fiji-Macros).","abstract":[{"text":"Neural tube closure is a critical morphogenetic process in vertebrate development, and failure to close cranial regions such as the hindbrain neuropore (HNP) leads to severe congenital malformations. While mechanical forces such as actomyosin purse-string contraction and directional cell crawling have been implicated in driving HNP closure, how these forces organize local cell shape and motion to produce large-scale tissue remodeling remains poorly understood. Using live and fixed imaging of mouse embryos combined with cell-based biophysical modeling, we show that these force-generating mechanisms are insufficient to explain the reproducible patterns of cell elongation and nematic alignment observed at the HNP border. Instead, we show that local anisotropic stress and cytoskeletal organization are required to generate these patterns and promote midline cell motion. Our model captures key features of cell shape dynamics and emergent nematic order, which we confirm experimentally, including the alignment of actin fibers with cell shape and enhanced midline cell speed. Comparative analysis with chick embryos, which lack supracellular purse strings, supports a conserved link between tension generation and cellular patterning. These findings establish a physical framework connecting force generation, cell shape anisotropy, and tissue morphodynamics during epithelial gap closure.","lang":"eng"}],"scopus_import":"1","date_published":"2026-04-20T00:00:00Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"file_name":"2026_CurrentBiology_PerezVerdugo.pdf","date_updated":"2026-04-28T13:13:40Z","checksum":"80ae45457b4682c50c84f54de15aa9a8","success":1,"relation":"main_file","file_size":13402043,"file_id":"21774","date_created":"2026-04-28T13:13:40Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf"}],"oa":1,"article_type":"original","publication_status":"published","author":[{"last_name":"Perez Verdugo","id":"4ecec223-9070-11ef-a0a9-bc76077bea8d","full_name":"Perez Verdugo, Fernanda L","first_name":"Fernanda L"},{"last_name":"Maniou","full_name":"Maniou, Eirini","first_name":"Eirini"},{"full_name":"Galea, Gabriel L.","first_name":"Gabriel L.","last_name":"Galea"},{"last_name":"Banerjee","full_name":"Banerjee, Shiladitya","first_name":"Shiladitya"}]},{"article_processing_charge":"No","month":"02","pmid":1,"oa_version":"Preprint","year":"2024","issue":"4","_id":"14479","title":"Fungal infection alters collective nutritional intake of ant colonies","author":[{"first_name":"Eniko","full_name":"Csata, Eniko","last_name":"Csata"},{"full_name":"Perez-Escudero, Alfonso","first_name":"Alfonso","last_name":"Perez-Escudero"},{"last_name":"Laury","full_name":"Laury, Emmanuel","first_name":"Emmanuel"},{"id":"8fc5c6f6-5903-11ec-abad-c83f046253e7","full_name":"Leitner, Hanna","first_name":"Hanna","last_name":"Leitner"},{"first_name":"Gerard","full_name":"Latil, Gerard","last_name":"Latil"},{"last_name":"Heinze","full_name":"Heinze, Juerge","first_name":"Juerge"},{"full_name":"Simpson, Stephen","first_name":"Stephen","last_name":"Simpson"},{"first_name":"Sylvia","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","orcid":"0000-0002-2193-3868"},{"first_name":"Audrey","full_name":"Dussutour, Audrey","last_name":"Dussutour"}],"publication_status":"published","article_type":"original","oa":1,"isi":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2024-02-26T00:00:00Z","abstract":[{"text":"In animals, parasitic infections impose significant fitness costs.1,2,3,4,5,6 Infected animals can alter their feeding behavior to resist infection,7,8,9,10,11,12 but parasites can manipulate animal foraging behavior to their own benefits.13,14,15,16 How nutrition influences host-parasite interactions is not well understood, as studies have mainly focused on the host and less on the parasite.9,12,17,18,19,20,21,22,23 We used the nutritional geometry framework24 to investigate the role of amino acids (AA) and carbohydrates (C) in a host-parasite system: the Argentine ant, Linepithema humile, and the entomopathogenic fungus, Metarhizium brunneum. First, using 18 diets varying in AA:C composition, we established that the fungus performed best on the high-amino-acid diet 1:4. Second, we found that the fungus reached this optimal diet when given various diet pairings, revealing its ability to cope with nutritional challenges. Third, we showed that the optimal fungal diet reduced the lifespan of healthy ants when compared with a high-carbohydrate diet but had no effect on infected ants. Fourth, we revealed that infected ant colonies, given a choice between the optimal fungal diet and a high-carbohydrate diet, chose the optimal fungal diet, whereas healthy colonies avoided it. Lastly, by disentangling fungal infection from host immune response, we demonstrated that infected ants foraged on the optimal fungal diet in response to immune activation and not as a result of parasite manipulation. Therefore, we revealed that infected ant colonies chose a diet that is costly for survival in the long term but beneficial in the short term—a form of collective self-medication.","lang":"eng"}],"scopus_import":"1","acknowledgement":"We are sincerely grateful to the referees for their valuable comments and suggestions, which helped us to improve the paper. We are thankful to Jorgen Eilenberg and Nicolai V. Meyling for the fungal strain, to Simon Tragust, Abel Bernadou, and Brian Lazarro for insightful discussions, to Iago Sanmartín-Villar, Léa Briard, Céline Maitrel, and Nolwenn Rissen for their help with the experiments. Furthermore, we thank Anna V. Grasse for help with the immune gene expression analyses. We thank Sergio Ibarra for creating the graphical abstract. E.C. was supported by a Fyssen Foundation grant and the Alexander von Humboldt Foundation. A.D. was supported by the CNRS.","publication":"Current Biology","main_file_link":[{"url":"https://doi.org/10.1101/2023.10.26.564092","open_access":"1"}],"volume":34,"citation":{"chicago":"Csata, Eniko, Alfonso Perez-Escudero, Emmanuel Laury, Hanna Leitner, Gerard Latil, Juerge Heinze, Stephen Simpson, Sylvia Cremer, and Audrey Dussutour. “Fungal Infection Alters Collective Nutritional Intake of Ant Colonies.” <i>Current Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">https://doi.org/10.1016/j.cub.2024.01.017</a>.","ama":"Csata E, Perez-Escudero A, Laury E, et al. Fungal infection alters collective nutritional intake of ant colonies. <i>Current Biology</i>. 2024;34(4):902-909.e6. doi:<a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">10.1016/j.cub.2024.01.017</a>","mla":"Csata, Eniko, et al. “Fungal Infection Alters Collective Nutritional Intake of Ant Colonies.” <i>Current Biology</i>, vol. 34, no. 4, Elsevier, 2024, p. 902–909.e6, doi:<a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">10.1016/j.cub.2024.01.017</a>.","apa":"Csata, E., Perez-Escudero, A., Laury, E., Leitner, H., Latil, G., Heinze, J., … Dussutour, A. (2024). Fungal infection alters collective nutritional intake of ant colonies. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2024.01.017\">https://doi.org/10.1016/j.cub.2024.01.017</a>","ista":"Csata E, Perez-Escudero A, Laury E, Leitner H, Latil G, Heinze J, Simpson S, Cremer S, Dussutour A. 2024. Fungal infection alters collective nutritional intake of ant colonies. Current Biology. 34(4), 902–909.e6.","ieee":"E. Csata <i>et al.</i>, “Fungal infection alters collective nutritional intake of ant colonies,” <i>Current Biology</i>, vol. 34, no. 4. Elsevier, p. 902–909.e6, 2024.","short":"E. Csata, A. Perez-Escudero, E. Laury, H. Leitner, G. Latil, J. Heinze, S. Simpson, S. Cremer, A. Dussutour, Current Biology 34 (2024) 902–909.e6."},"type":"journal_article","page":"902-909.e6","day":"26","publisher":"Elsevier","doi":"10.1016/j.cub.2024.01.017","department":[{"_id":"SyCr"}],"date_created":"2023-10-31T13:30:20Z","publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"intvolume":"        34","quality_controlled":"1","language":[{"iso":"eng"}],"external_id":{"pmid":["38307022"],"isi":["001195884300001"]},"date_updated":"2025-08-05T13:29:38Z"},{"date_updated":"2025-09-09T11:51:15Z","external_id":{"pmid":["39689690"],"isi":["001392077000001"]},"corr_author":"1","intvolume":"        34","quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"date_created":"2024-12-15T23:01:49Z","department":[{"_id":"CaHe"}],"page":"R1230-R1232","day":"16","doi":"10.1016/j.cub.2024.10.065","publisher":"Elsevier","type":"journal_article","citation":{"ama":"Hino N, Santos Fernandes Lasbarrères Camelo C, Heisenberg C-PJ. Development: Turing mechanics. <i>Current Biology</i>. 2024;34(24):R1230-R1232. doi:<a href=\"https://doi.org/10.1016/j.cub.2024.10.065\">10.1016/j.cub.2024.10.065</a>","chicago":"Hino, Naoya, Carolina Santos Fernandes Lasbarrères Camelo, and Carl-Philipp J Heisenberg. “Development: Turing Mechanics.” <i>Current Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cub.2024.10.065\">https://doi.org/10.1016/j.cub.2024.10.065</a>.","short":"N. Hino, C. Santos Fernandes Lasbarrères Camelo, C.-P.J. Heisenberg, Current Biology 34 (2024) R1230–R1232.","ista":"Hino N, Santos Fernandes Lasbarrères Camelo C, Heisenberg C-PJ. 2024. Development: Turing mechanics. Current Biology. 34(24), R1230–R1232.","mla":"Hino, Naoya, et al. “Development: Turing Mechanics.” <i>Current Biology</i>, vol. 34, no. 24, Elsevier, 2024, pp. R1230–32, doi:<a href=\"https://doi.org/10.1016/j.cub.2024.10.065\">10.1016/j.cub.2024.10.065</a>.","apa":"Hino, N., Santos Fernandes Lasbarrères Camelo, C., &#38; Heisenberg, C.-P. J. (2024). Development: Turing mechanics. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2024.10.065\">https://doi.org/10.1016/j.cub.2024.10.065</a>","ieee":"N. Hino, C. Santos Fernandes Lasbarrères Camelo, and C.-P. J. Heisenberg, “Development: Turing mechanics,” <i>Current Biology</i>, vol. 34, no. 24. Elsevier, pp. R1230–R1232, 2024."},"volume":34,"publication":"Current Biology","OA_type":"closed access","date_published":"2024-12-16T00:00:00Z","abstract":[{"lang":"eng","text":"Embryo axis formation begins with the localized expression of biochemical signals, which organize cell movements and determine cell fate. A quail study finds that tissue contraction and resulting long-range changes in tissue tension restrict the area where these biochemical signals are expressed."}],"scopus_import":"1","status":"public","isi":1,"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","publication_status":"published","article_type":"letter_note","author":[{"last_name":"Hino","id":"5299a9ce-7679-11eb-a7bc-d1e62b936307","full_name":"Hino, Naoya","first_name":"Naoya"},{"last_name":"Santos Fernandes Lasbarrères Camelo","first_name":"Carolina","id":"6347dca5-074c-11ed-af92-a80f860d9d5b","full_name":"Santos Fernandes Lasbarrères Camelo, Carolina"},{"orcid":"0000-0002-0912-4566","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J"}],"title":"Development: Turing mechanics","year":"2024","issue":"24","_id":"18651","oa_version":"None","pmid":1,"month":"12","article_processing_charge":"No"},{"file":[{"success":1,"checksum":"51220b76d72a614208f84bdbfbaf9b72","date_updated":"2024-01-16T10:53:31Z","file_name":"2024_CurrentBiology_Arslan.pdf","content_type":"application/pdf","access_level":"open_access","creator":"dernst","date_created":"2024-01-16T10:53:31Z","file_id":"14813","relation":"main_file","file_size":5183861}],"user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","isi":1,"oa":1,"project":[{"name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","call_identifier":"H2020","grant_number":"742573","_id":"260F1432-B435-11E9-9278-68D0E5697425"}],"publication_status":"published","article_type":"original","author":[{"first_name":"Feyza N","id":"49DA7910-F248-11E8-B48F-1D18A9856A87","full_name":"Arslan, Feyza N","orcid":"0000-0001-5809-9566","last_name":"Arslan"},{"orcid":"0000-0001-6005-1561","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","full_name":"Hannezo, Edouard B","first_name":"Edouard B"},{"orcid":"0000-0001-5145-4609","last_name":"Merrin","full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","first_name":"Jack"},{"first_name":"Martin","full_name":"Loose, Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-7309-9724","last_name":"Loose"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg"}],"acknowledgement":"We are grateful to Edwin Munro for their feedback and help with the single particle analysis. We thank members of the Heisenberg and Loose labs for their help and feedback on the manuscript, notably Xin Tong for making the PCS2-mCherry-AHPH plasmid. Finally, we thank the Aquatics and Imaging & Optics facilities of ISTA for their continuous support, especially Yann Cesbron for assistance with the laser cutter. This work was supported by an ERC\r\nAdvanced Grant (MECSPEC) to C.-P.H.","ddc":["570"],"scopus_import":"1","date_published":"2024-01-08T00:00:00Z","abstract":[{"lang":"eng","text":"Metazoan development relies on the formation and remodeling of cell-cell contacts. Dynamic reorganization of adhesion receptors and the actomyosin cell cortex in space and time plays a central role in cell-cell contact formation and maturation. Nevertheless, how this process is mechanistically achieved when new contacts are formed remains unclear. Here, by building a biomimetic assay composed of progenitor cells adhering to supported lipid bilayers functionalized with E-cadherin ectodomains, we show that cortical F-actin flows, driven by the depletion of myosin-2 at the cell contact center, mediate the dynamic reorganization of adhesion receptors and cell cortex at the contact. E-cadherin-dependent downregulation of the small GTPase RhoA at the forming contact leads to both a depletion of myosin-2 and a decrease of F-actin at the contact center. At the contact rim, in contrast, myosin-2 becomes enriched by the retraction of bleb-like protrusions, resulting in a cortical tension gradient from the contact rim to its center. This tension gradient, in turn, triggers centrifugal F-actin flows, leading to further accumulation of F-actin at the contact rim and the progressive redistribution of E-cadherin from the contact center to the rim. Eventually, this combination of actomyosin downregulation and flows at the contact determines the characteristic molecular organization, with E-cadherin and F-actin accumulating at the contact rim, where they are needed to mechanically link the contractile cortices of the adhering cells."}],"status":"public","pmid":1,"month":"01","article_processing_charge":"Yes (via OA deal)","title":"Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts","year":"2024","issue":"1","_id":"14795","oa_version":"Published Version","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"acknowledged_ssus":[{"_id":"Bio"},{"_id":"PreCl"}],"file_date_updated":"2024-01-16T10:53:31Z","date_created":"2024-01-14T23:00:56Z","department":[{"_id":"CaHe"},{"_id":"EdHa"},{"_id":"MaLo"},{"_id":"NanoFab"}],"date_updated":"2025-09-04T11:39:10Z","has_accepted_license":"1","external_id":{"isi":["001154500400001"],"pmid":["38134934"]},"corr_author":"1","intvolume":"        34","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"publication":"Current Biology","page":"171-182.e8","publisher":"Elsevier","doi":"10.1016/j.cub.2023.11.067","day":"08","type":"journal_article","ec_funded":1,"citation":{"ieee":"F. N. Arslan, E. B. Hannezo, J. Merrin, M. Loose, and C.-P. J. Heisenberg, “Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts,” <i>Current Biology</i>, vol. 34, no. 1. Elsevier, p. 171–182.e8, 2024.","apa":"Arslan, F. N., Hannezo, E. B., Merrin, J., Loose, M., &#38; Heisenberg, C.-P. J. (2024). Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">https://doi.org/10.1016/j.cub.2023.11.067</a>","ista":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. 2024. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. Current Biology. 34(1), 171–182.e8.","mla":"Arslan, Feyza N., et al. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” <i>Current Biology</i>, vol. 34, no. 1, Elsevier, 2024, p. 171–182.e8, doi:<a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">10.1016/j.cub.2023.11.067</a>.","short":"F.N. Arslan, E.B. Hannezo, J. Merrin, M. Loose, C.-P.J. Heisenberg, Current Biology 34 (2024) 171–182.e8.","chicago":"Arslan, Feyza N, Edouard B Hannezo, Jack Merrin, Martin Loose, and Carl-Philipp J Heisenberg. “Adhesion-Induced Cortical Flows Pattern E-Cadherin-Mediated Cell Contacts.” <i>Current Biology</i>. Elsevier, 2024. <a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">https://doi.org/10.1016/j.cub.2023.11.067</a>.","ama":"Arslan FN, Hannezo EB, Merrin J, Loose M, Heisenberg C-PJ. Adhesion-induced cortical flows pattern E-cadherin-mediated cell contacts. <i>Current Biology</i>. 2024;34(1):171-182.e8. doi:<a href=\"https://doi.org/10.1016/j.cub.2023.11.067\">10.1016/j.cub.2023.11.067</a>"},"volume":34},{"publication":"Current Biology","volume":32,"citation":{"ama":"Nicolas WJ, Fäßler F, Dutka P, Schur FK, Jensen G, Meyerowitz E. Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. <i>Current Biology</i>. 2022;32(11):P2375-2389. doi:<a href=\"https://doi.org/10.1016/j.cub.2022.04.024\">10.1016/j.cub.2022.04.024</a>","chicago":"Nicolas, William J., Florian Fäßler, Przemysław Dutka, Florian KM Schur, Grant Jensen, and Elliot Meyerowitz. “Cryo-Electron Tomography of the Onion Cell Wall Shows Bimodally Oriented Cellulose Fibers and Reticulated Homogalacturonan Networks.” <i>Current Biology</i>. Elsevier, 2022. <a href=\"https://doi.org/10.1016/j.cub.2022.04.024\">https://doi.org/10.1016/j.cub.2022.04.024</a>.","short":"W.J. Nicolas, F. Fäßler, P. Dutka, F.K. Schur, G. Jensen, E. Meyerowitz, Current Biology 32 (2022) P2375-2389.","apa":"Nicolas, W. J., Fäßler, F., Dutka, P., Schur, F. K., Jensen, G., &#38; Meyerowitz, E. (2022). Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2022.04.024\">https://doi.org/10.1016/j.cub.2022.04.024</a>","mla":"Nicolas, William J., et al. “Cryo-Electron Tomography of the Onion Cell Wall Shows Bimodally Oriented Cellulose Fibers and Reticulated Homogalacturonan Networks.” <i>Current Biology</i>, vol. 32, no. 11, Elsevier, 2022, pp. P2375-2389, doi:<a href=\"https://doi.org/10.1016/j.cub.2022.04.024\">10.1016/j.cub.2022.04.024</a>.","ista":"Nicolas WJ, Fäßler F, Dutka P, Schur FK, Jensen G, Meyerowitz E. 2022. Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks. Current Biology. 32(11), P2375-2389.","ieee":"W. J. Nicolas, F. Fäßler, P. Dutka, F. K. Schur, G. Jensen, and E. Meyerowitz, “Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks,” <i>Current Biology</i>, vol. 32, no. 11. Elsevier, pp. P2375-2389, 2022."},"type":"journal_article","page":"P2375-2389","day":"06","publisher":"Elsevier","doi":"10.1016/j.cub.2022.04.024","department":[{"_id":"FlSc"}],"file_date_updated":"2022-08-05T06:29:18Z","date_created":"2022-05-04T06:22:06Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"publication_identifier":{"issn":["0960-9822"]},"intvolume":"        32","quality_controlled":"1","language":[{"iso":"eng"}],"external_id":{"pmid":["35508170"],"isi":["000822399200019"]},"date_updated":"2025-04-15T08:25:40Z","has_accepted_license":"1","article_processing_charge":"No","month":"06","pmid":1,"oa_version":"Published Version","year":"2022","issue":"11","_id":"11351","title":"Cryo-electron tomography of the onion cell wall shows bimodally oriented cellulose fibers and reticulated homogalacturonan networks","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"author":[{"last_name":"Nicolas","full_name":"Nicolas, William J.","first_name":"William J."},{"last_name":"Fäßler","orcid":"0000-0001-7149-769X","full_name":"Fäßler, Florian","id":"404F5528-F248-11E8-B48F-1D18A9856A87","first_name":"Florian"},{"full_name":"Dutka, Przemysław","first_name":"Przemysław","last_name":"Dutka"},{"first_name":"Florian KM","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian KM","orcid":"0000-0003-4790-8078","last_name":"Schur"},{"last_name":"Jensen","first_name":"Grant","full_name":"Jensen, Grant"},{"last_name":"Meyerowitz","full_name":"Meyerowitz, Elliot","first_name":"Elliot"}],"project":[{"name":"Structure and isoform diversity of the Arp2/3 complex","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","grant_number":"P33367"}],"article_type":"original","publication_status":"published","oa":1,"file":[{"checksum":"af3f24d97c016d844df237abef987639","success":1,"file_name":"2022_CurrentBiology_Nicolas.pdf","date_updated":"2022-08-05T06:29:18Z","creator":"dernst","date_created":"2022-08-05T06:29:18Z","access_level":"open_access","content_type":"application/pdf","file_size":12827717,"relation":"main_file","file_id":"11730"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","isi":1,"status":"public","abstract":[{"text":"One hallmark of plant cells is their cell wall. They protect cells against the environment and high turgor and mediate morphogenesis through the dynamics of their mechanical and chemical properties. The walls are a complex polysaccharidic structure. Although their biochemical composition is well known, how the different components organize in the volume of the cell wall and interact with each other is not well understood and yet is key to the wall’s mechanical properties. To investigate the ultrastructure of the plant cell wall, we imaged the walls of onion (Allium cepa) bulbs in a near-native state via cryo-focused ion beam milling (cryo-FIB milling) and cryo-electron tomography (cryo-ET). This allowed the high-resolution visualization of cellulose fibers in situ. We reveal the coexistence of dense fiber fields bathed in a reticulated matrix we termed “meshing,” which is more abundant at the inner surface of the cell wall. The fibers adopted a regular bimodal angular distribution at all depths in the cell wall and bundled according to their orientation, creating layers within the cell wall. Concomitantly, employing homogalacturonan (HG)-specific enzymatic digestion, we observed changes in the meshing, suggesting that it is—at least in part—composed of HG pectins. We propose the following model for the construction of the abaxial epidermal primary cell wall: the cell deposits successive layers of cellulose fibers at −45° and +45° relative to the cell’s long axis and secretes the surrounding HG-rich meshing proximal to the plasma membrane, which then migrates to more distal regions of the cell wall.","lang":"eng"}],"date_published":"2022-06-06T00:00:00Z","scopus_import":"1","acknowledgement":"This work was supported by the Howard Hughes Medical Institute (HHMI) and grant R35 GM122588 to G.J. and the Austrian Science Fund (FWF) P33367 to F.K.M.S. We thank Noé Cochetel for his guidance and great help in data analysis, discovery, and representation with the R software. We thank Hans-Ulrich Endress for graciously providing us with the purified citrus pectin and Jozef Mravec for generating and providing the COS488 probe. Cryo-EM work was done in the Beckman Institute Resource Center for Transmission Electron Microscopy at Caltech. This article is subject to HHMI’s Open Access to Publications policy. HHMI lab heads have previously granted a nonexclusive CC BY 4.0 license to the public and a sublicensable license to HHMI in their research articles. Pursuant to those licenses, the author accepted manuscript of this article can be made freely available under a CC BY 4.0 license immediately upon publication.","ddc":["570"]},{"doi":"10.1016/j.cub.2021.02.043","day":"24","publisher":"Elsevier","page":"2051-2064.e8","type":"journal_article","citation":{"chicago":"Stahnke, Stephanie, Hermann Döring, Charly Kusch, David J.J. de Gorter, Sebastian Dütting, Aleks Guledani, Irina Pleines, et al. “Loss of Hem1 Disrupts Macrophage Function and Impacts Migration, Phagocytosis, and Integrin-Mediated Adhesion.” <i>Current Biology</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cub.2021.02.043\">https://doi.org/10.1016/j.cub.2021.02.043</a>.","ama":"Stahnke S, Döring H, Kusch C, et al. Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion. <i>Current Biology</i>. 2021;31(10):2051-2064.e8. doi:<a href=\"https://doi.org/10.1016/j.cub.2021.02.043\">10.1016/j.cub.2021.02.043</a>","ieee":"S. Stahnke <i>et al.</i>, “Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion,” <i>Current Biology</i>, vol. 31, no. 10. Elsevier, p. 2051–2064.e8, 2021.","ista":"Stahnke S, Döring H, Kusch C, de Gorter DJJ, Dütting S, Guledani A, Pleines I, Schnoor M, Sixt MK, Geffers R, Rohde M, Müsken M, Kage F, Steffen A, Faix J, Nieswandt B, Rottner K, Stradal TEB. 2021. Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion. Current Biology. 31(10), 2051–2064.e8.","mla":"Stahnke, Stephanie, et al. “Loss of Hem1 Disrupts Macrophage Function and Impacts Migration, Phagocytosis, and Integrin-Mediated Adhesion.” <i>Current Biology</i>, vol. 31, no. 10, Elsevier, 2021, p. 2051–2064.e8, doi:<a href=\"https://doi.org/10.1016/j.cub.2021.02.043\">10.1016/j.cub.2021.02.043</a>.","apa":"Stahnke, S., Döring, H., Kusch, C., de Gorter, D. J. J., Dütting, S., Guledani, A., … Stradal, T. E. B. (2021). Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2021.02.043\">https://doi.org/10.1016/j.cub.2021.02.043</a>","short":"S. Stahnke, H. Döring, C. Kusch, D.J.J. de Gorter, S. Dütting, A. Guledani, I. Pleines, M. Schnoor, M.K. Sixt, R. Geffers, M. Rohde, M. Müsken, F. Kage, A. Steffen, J. Faix, B. Nieswandt, K. Rottner, T.E.B. Stradal, Current Biology 31 (2021) 2051–2064.e8."},"volume":31,"main_file_link":[{"url":"https://doi.org/10.1101/2020.03.24.005835","open_access":"1"}],"publication":"Current Biology","date_updated":"2023-08-17T07:01:14Z","external_id":{"pmid":["33711252"],"isi":["000654652200002"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        31","publication_identifier":{"issn":["0960-9822"]},"date_created":"2022-03-08T07:51:04Z","department":[{"_id":"MiSi"}],"keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"title":"Loss of Hem1 disrupts macrophage function and impacts migration, phagocytosis, and integrin-mediated adhesion","_id":"10834","issue":"10","year":"2021","oa_version":"Preprint","pmid":1,"month":"05","article_processing_charge":"No","acknowledgement":"We are grateful to Silvia Prettin, Ina Schleicher, and Petra Hagendorff for expert technical assistance; David Dettbarn for animal keeping and breeding; and Lothar Gröbe and Maria Höxter for cell sorting. We also thank Werner Tegge for peptides and Giorgio Scita for antibodies. This work was supported, in part, by the Deutsche Forschungsgemeinschaft (DFG), Priority Programm SPP1150 (to T.E.B.S., K.R., and M. Sixt), and by DFG grant GRK2223/1 (to K.R.). T.E.B.S. acknowledges support by the Helmholtz Society through HGF impulse fund W2/W3-066 and M. Schnoor by the Mexican Council for Science and Technology (CONACyT, 284292 ), Fund SEP-Cinvestav ( 108 ), and the Royal Society, UK (Newton Advanced Fellowship, NAF/R1/180017 ).","abstract":[{"lang":"eng","text":"Hematopoietic-specific protein 1 (Hem1) is an essential subunit of the WAVE regulatory complex (WRC) in immune cells. WRC is crucial for Arp2/3 complex activation and the protrusion of branched actin filament networks. Moreover, Hem1 loss of function in immune cells causes autoimmune diseases in humans. Here, we show that genetic removal of Hem1 in macrophages diminishes frequency and efficacy of phagocytosis as well as phagocytic cup formation in addition to defects in lamellipodial protrusion and migration. Moreover, Hem1-null macrophages displayed strong defects in cell adhesion despite unaltered podosome formation and concomitant extracellular matrix degradation. Specifically, dynamics of both adhesion and de-adhesion as well as concomitant phosphorylation of paxillin and focal adhesion kinase (FAK) were significantly compromised. Accordingly, disruption of WRC function in non-hematopoietic cells coincided with both defects in adhesion turnover and altered FAK and paxillin phosphorylation. Consistently, platelets exhibited reduced adhesion and diminished integrin αIIbβ3 activation upon WRC removal. Interestingly, adhesion phenotypes, but not lamellipodia formation, were partially rescued by small molecule activation of FAK. A full rescue of the phenotype, including lamellipodia formation, required not only the presence of WRCs but also their binding to and activation by Rac. Collectively, our results uncover that WRC impacts on integrin-dependent processes in a FAK-dependent manner, controlling formation and dismantling of adhesions, relevant for properly grabbing onto extracellular surfaces and particles during cell edge expansion, like in migration or phagocytosis."}],"scopus_import":"1","date_published":"2021-05-24T00:00:00Z","status":"public","isi":1,"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa":1,"publication_status":"published","article_type":"original","author":[{"last_name":"Stahnke","first_name":"Stephanie","full_name":"Stahnke, Stephanie"},{"first_name":"Hermann","full_name":"Döring, Hermann","last_name":"Döring"},{"last_name":"Kusch","full_name":"Kusch, Charly","first_name":"Charly"},{"last_name":"de Gorter","full_name":"de Gorter, David J.J.","first_name":"David J.J."},{"first_name":"Sebastian","full_name":"Dütting, Sebastian","last_name":"Dütting"},{"first_name":"Aleks","full_name":"Guledani, Aleks","last_name":"Guledani"},{"last_name":"Pleines","full_name":"Pleines, Irina","first_name":"Irina"},{"first_name":"Michael","full_name":"Schnoor, Michael","last_name":"Schnoor"},{"orcid":"0000-0002-6620-9179","last_name":"Sixt","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","first_name":"Michael K"},{"first_name":"Robert","full_name":"Geffers, Robert","last_name":"Geffers"},{"last_name":"Rohde","first_name":"Manfred","full_name":"Rohde, Manfred"},{"full_name":"Müsken, Mathias","first_name":"Mathias","last_name":"Müsken"},{"full_name":"Kage, Frieda","first_name":"Frieda","last_name":"Kage"},{"first_name":"Anika","full_name":"Steffen, Anika","last_name":"Steffen"},{"full_name":"Faix, Jan","first_name":"Jan","last_name":"Faix"},{"full_name":"Nieswandt, Bernhard","first_name":"Bernhard","last_name":"Nieswandt"},{"last_name":"Rottner","full_name":"Rottner, Klemens","first_name":"Klemens"},{"full_name":"Stradal, Theresia E.B.","first_name":"Theresia E.B.","last_name":"Stradal"}]},{"status":"public","abstract":[{"lang":"eng","text":"Plants are able to orient their growth according to gravity, which ultimately controls both shoot and root architecture.1 Gravitropism is a dynamic process whereby gravistimulation induces the asymmetric distribution of the plant hormone auxin, leading to asymmetric growth, organ bending, and subsequent reset of auxin distribution back to the original pre-gravistimulation situation.1,  2,  3 Differential auxin accumulation during the gravitropic response depends on the activity of polarly localized PIN-FORMED (PIN) auxin-efflux carriers.1,  2,  3,  4 In particular, the timing of this dynamic response is regulated by PIN2,5,6 but the underlying molecular mechanisms are poorly understood. Here, we show that MEMBRANE ASSOCIATED KINASE REGULATOR2 (MAKR2) controls the pace of the root gravitropic response. We found that MAKR2 is required for the PIN2 asymmetry during gravitropism by acting as a negative regulator of the cell-surface signaling mediated by the receptor-like kinase TRANSMEMBRANE KINASE1 (TMK1).2,7,  8,  9,  10 Furthermore, we show that the MAKR2 inhibitory effect on TMK1 signaling is antagonized by auxin itself, which triggers rapid MAKR2 membrane dissociation in a TMK1-dependent manner. Our findings suggest that the timing of the root gravitropic response is orchestrated by the reversible inhibition of the TMK1 signaling pathway at the cell surface."}],"scopus_import":"1","date_published":"2021-01-11T00:00:00Z","ddc":["570"],"acknowledgement":"We thank the SiCE group for discussions and comments; S. Yalovsky, B. Scheres, and the NASC/ABRC collection for providing transgenic Arabidopsis lines and plasmids; L. Kalmbach and M. Barberon for the gift of pLOK180_pFR7m34GW; A. Lacroix, J. Berger, and P. Bolland for plant care; and M. Fendrych for help with microfluidics in the J.F. lab. We acknowledge\r\nthe contribution of the SFR Biosciences (UMS3444/CNRS, US8/Inser m, ENS de Lyon, UCBL) facilities: C. Lionet, E. Chatre, and J. Brocard at LBIPLATIM-MICROSCOPY for assistance with imaging, and V. GuegenChaignon and A. Page at the Protein Science Facility (PSF) for assistance with protein purification and mass spectrometry. Y.J. was funded by ERC\r\ngrant 3363360-APPL under FP/2007–2013. Y.J. and Z.L.N. were funded by an ANR- and NSF-supported ERA-CAPS project (SICOPID: ANR-17-CAPS0003-01/NSF PGRP IOS-1841917). A.I.C.-D. is funded by an ERC consolidator grant (ERC-2015-CoG–683163) and BIO2016-78955 grant from the Spanish Ministry of Economy and Competitiveness. Exchanges between the Y.J. and T.B. laboratories were funded by Tournesol grant 35656NB. B.K.M. was\r\nfunded by the Omics@vib Marie Curie COFUND and Research Foundation Flanders for a postdoctoral fellowship.","author":[{"last_name":"Marquès-Bueno","first_name":"MM","full_name":"Marquès-Bueno, MM"},{"full_name":"Armengot, L","first_name":"L","last_name":"Armengot"},{"last_name":"Noack","full_name":"Noack, LC","first_name":"LC"},{"last_name":"Bareille","full_name":"Bareille, J","first_name":"J"},{"orcid":"0000-0002-7244-7237","last_name":"Rodriguez Solovey","full_name":"Rodriguez Solovey, Lesia","id":"3922B506-F248-11E8-B48F-1D18A9856A87","first_name":"Lesia"},{"last_name":"Platre","first_name":"MP","full_name":"Platre, MP"},{"full_name":"Bayle, V","first_name":"V","last_name":"Bayle"},{"last_name":"Liu","full_name":"Liu, M","first_name":"M"},{"first_name":"D","full_name":"Opdenacker, D","last_name":"Opdenacker"},{"last_name":"Vanneste","full_name":"Vanneste, S","first_name":"S"},{"last_name":"Möller","full_name":"Möller, BK","first_name":"BK"},{"last_name":"Nimchuk","full_name":"Nimchuk, ZL","first_name":"ZL"},{"last_name":"Beeckman","full_name":"Beeckman, T","first_name":"T"},{"last_name":"Caño-Delgado","first_name":"AI","full_name":"Caño-Delgado, AI"},{"orcid":"0000-0002-8302-7596","last_name":"Friml","full_name":"Friml, Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří"},{"full_name":"Jaillais, Y","first_name":"Y","last_name":"Jaillais"}],"publication_status":"published","article_type":"original","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","isi":1,"file":[{"content_type":"application/pdf","access_level":"open_access","date_created":"2021-02-04T11:37:50Z","creator":"dernst","file_id":"9090","file_size":3458646,"relation":"main_file","success":1,"checksum":"30b3393d841fb2b1e2b22fb42b5c8fff","date_updated":"2021-02-04T11:37:50Z","file_name":"2021_CurrentBiology_MarquesBueno.pdf"}],"oa_version":"Published Version","_id":"8824","issue":"1","year":"2021","title":"Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism","article_processing_charge":"Yes (via OA deal)","month":"01","pmid":1,"publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        31","external_id":{"isi":["000614361000039"],"pmid":["33157019"]},"has_accepted_license":"1","date_updated":"2024-10-21T06:02:09Z","department":[{"_id":"JiFr"}],"file_date_updated":"2021-02-04T11:37:50Z","date_created":"2020-12-01T13:39:46Z","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"volume":31,"citation":{"chicago":"Marquès-Bueno, MM, L Armengot, LC Noack, J Bareille, Lesia Rodriguez Solovey, MP Platre, V Bayle, et al. “Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism.” <i>Current Biology</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cub.2020.10.011\">https://doi.org/10.1016/j.cub.2020.10.011</a>.","ama":"Marquès-Bueno M, Armengot L, Noack L, et al. Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism. <i>Current Biology</i>. 2021;31(1). doi:<a href=\"https://doi.org/10.1016/j.cub.2020.10.011\">10.1016/j.cub.2020.10.011</a>","ieee":"M. Marquès-Bueno <i>et al.</i>, “Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism,” <i>Current Biology</i>, vol. 31, no. 1. Elsevier, 2021.","apa":"Marquès-Bueno, M., Armengot, L., Noack, L., Bareille, J., Rodriguez Solovey, L., Platre, M., … Jaillais, Y. (2021). Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2020.10.011\">https://doi.org/10.1016/j.cub.2020.10.011</a>","ista":"Marquès-Bueno M, Armengot L, Noack L, Bareille J, Rodriguez Solovey L, Platre M, Bayle V, Liu M, Opdenacker D, Vanneste S, Möller B, Nimchuk Z, Beeckman T, Caño-Delgado A, Friml J, Jaillais Y. 2021. Auxin-regulated reversible inhibition of TMK1 signaling by MAKR2 modulates the dynamics of root gravitropism. Current Biology. 31(1).","mla":"Marquès-Bueno, MM, et al. “Auxin-Regulated Reversible Inhibition of TMK1 Signaling by MAKR2 Modulates the Dynamics of Root Gravitropism.” <i>Current Biology</i>, vol. 31, no. 1, Elsevier, 2021, doi:<a href=\"https://doi.org/10.1016/j.cub.2020.10.011\">10.1016/j.cub.2020.10.011</a>.","short":"M. Marquès-Bueno, L. Armengot, L. Noack, J. Bareille, L. Rodriguez Solovey, M. Platre, V. Bayle, M. Liu, D. Opdenacker, S. Vanneste, B. Möller, Z. Nimchuk, T. Beeckman, A. Caño-Delgado, J. Friml, Y. Jaillais, Current Biology 31 (2021)."},"type":"journal_article","day":"11","publisher":"Elsevier","doi":"10.1016/j.cub.2020.10.011","publication":"Current Biology"},{"publication":"Current Biology","ec_funded":1,"type":"journal_article","day":"10","doi":"10.1016/j.cub.2021.02.028","publisher":"Elsevier","page":"1918-1930","volume":31,"citation":{"short":"M. Glanc, K. Van Gelderen, L. Hörmayer, S. Tan, S. Naramoto, X. Zhang, D. Domjan, L. Vcelarova, R. Hauschild, A.J. Johnson, E. de Koning, M. van Dop, E. Rademacher, S. Janson, X. Wei, G. Molnar, M. Fendrych, B. De Rybel, R. Offringa, J. Friml, Current Biology 31 (2021) 1918–1930.","ista":"Glanc M, Van Gelderen K, Hörmayer L, Tan S, Naramoto S, Zhang X, Domjan D, Vcelarova L, Hauschild R, Johnson AJ, de Koning E, van Dop M, Rademacher E, Janson S, Wei X, Molnar G, Fendrych M, De Rybel B, Offringa R, Friml J. 2021. AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. Current Biology. 31(9), 1918–1930.","apa":"Glanc, M., Van Gelderen, K., Hörmayer, L., Tan, S., Naramoto, S., Zhang, X., … Friml, J. (2021). AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">https://doi.org/10.1016/j.cub.2021.02.028</a>","mla":"Glanc, Matous, et al. “AGC Kinases and MAB4/MEL Proteins Maintain PIN Polarity by Limiting Lateral Diffusion in Plant Cells.” <i>Current Biology</i>, vol. 31, no. 9, Elsevier, 2021, pp. 1918–30, doi:<a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">10.1016/j.cub.2021.02.028</a>.","ieee":"M. Glanc <i>et al.</i>, “AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells,” <i>Current Biology</i>, vol. 31, no. 9. Elsevier, pp. 1918–1930, 2021.","ama":"Glanc M, Van Gelderen K, Hörmayer L, et al. AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells. <i>Current Biology</i>. 2021;31(9):1918-1930. doi:<a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">10.1016/j.cub.2021.02.028</a>","chicago":"Glanc, Matous, K Van Gelderen, Lukas Hörmayer, Shutang Tan, S Naramoto, Xixi Zhang, David Domjan, et al. “AGC Kinases and MAB4/MEL Proteins Maintain PIN Polarity by Limiting Lateral Diffusion in Plant Cells.” <i>Current Biology</i>. Elsevier, 2021. <a href=\"https://doi.org/10.1016/j.cub.2021.02.028\">https://doi.org/10.1016/j.cub.2021.02.028</a>."},"acknowledged_ssus":[{"_id":"Bio"}],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"department":[{"_id":"JiFr"}],"date_created":"2021-03-26T12:09:33Z","file_date_updated":"2021-04-01T10:53:42Z","corr_author":"1","external_id":{"pmid":["33705718"],"isi":["000653077800004"]},"has_accepted_license":"1","date_updated":"2025-04-14T07:45:00Z","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"        31","month":"03","pmid":1,"article_processing_charge":"No","title":"AGC kinases and MAB4/MEL proteins maintain PIN polarity by limiting lateral diffusion in plant cells","oa_version":"Published Version","issue":"9","_id":"9290","year":"2021","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","isi":1,"file":[{"date_created":"2021-04-01T10:53:42Z","creator":"dernst","access_level":"open_access","content_type":"application/pdf","relation":"main_file","file_size":4324371,"file_id":"9303","checksum":"b1723040ecfd8c81194185472eb62546","success":1,"file_name":"2021_CurrentBiology_Glanc.pdf","date_updated":"2021-04-01T10:53:42Z"}],"author":[{"first_name":"Matous","id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","full_name":"Glanc, Matous","last_name":"Glanc","orcid":"0000-0003-0619-7783"},{"full_name":"Van Gelderen, K","first_name":"K","last_name":"Van Gelderen"},{"first_name":"Lukas","full_name":"Hörmayer, Lukas","id":"2EEE7A2A-F248-11E8-B48F-1D18A9856A87","last_name":"Hörmayer","orcid":"0000-0001-8295-2926"},{"orcid":"0000-0002-0471-8285","last_name":"Tan","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","full_name":"Tan, Shutang","first_name":"Shutang"},{"last_name":"Naramoto","full_name":"Naramoto, S","first_name":"S"},{"last_name":"Zhang","orcid":"0000-0001-7048-4627","first_name":"Xixi","full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A"},{"last_name":"Domjan","orcid":"0000-0003-2267-106X","first_name":"David","id":"C684CD7A-257E-11EA-9B6F-D8588B4F947F","full_name":"Domjan, David"},{"full_name":"Vcelarova, L","first_name":"L","last_name":"Vcelarova"},{"id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","full_name":"Hauschild, Robert","first_name":"Robert","last_name":"Hauschild","orcid":"0000-0001-9843-3522"},{"first_name":"Alexander J","full_name":"Johnson, Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2739-8843","last_name":"Johnson"},{"first_name":"E","full_name":"de Koning, E","last_name":"de Koning"},{"last_name":"van Dop","full_name":"van Dop, M","first_name":"M"},{"full_name":"Rademacher, E","first_name":"E","last_name":"Rademacher"},{"first_name":"S","full_name":"Janson, S","last_name":"Janson"},{"last_name":"Wei","full_name":"Wei, X","first_name":"X"},{"first_name":"Gergely","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87","full_name":"Molnar, Gergely","last_name":"Molnar"},{"first_name":"Matyas","id":"43905548-F248-11E8-B48F-1D18A9856A87","full_name":"Fendrych, Matyas","orcid":"0000-0002-9767-8699","last_name":"Fendrych"},{"full_name":"De Rybel, B","first_name":"B","last_name":"De Rybel"},{"full_name":"Offringa, R","first_name":"R","last_name":"Offringa"},{"first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml"}],"publication_status":"published","article_type":"original","project":[{"call_identifier":"H2020","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985"},{"_id":"26538374-B435-11E9-9278-68D0E5697425","grant_number":"I03630","call_identifier":"FWF","name":"Molecular mechanisms of endocytic cargo recognition in plants"}],"ddc":["580"],"acknowledgement":"We acknowledge Ben Scheres, Christian Luschnig, and Claus Schwechheimer for sharing published material. We thank Monika Hrtyan and Dorota Jaworska at IST Austria and Gerda Lamers and Ward de Winter at IBL Netherlands for technical assistance; Corinna Hartinger, Jakub Hajný, Lesia Rodriguez, Mingyue Li, and Lindy Abas for experimental support; and the Bioimaging Facility at IST Austria and the Bioimaging Core at VIB for imaging support. We are grateful to Christian Luschnig, Lindy Abas, and Roman Pleskot for valuable discussions. We also acknowledge the EMBO for supporting M.G. with a long-term fellowship ( ALTF 1005-2019 ) during the finalization and revision of this manuscript in the laboratory of B.D.R., and we thank R. Pierik for allowing K.V.G. to work on this manuscript during a postdoc in his laboratory at Utrecht University. This work was supported by grants from the European Research Council under the European Union’s Seventh Framework Programme (ERC grant agreements 742985 to J.F., 714055 to B.D.R., and 803048 to M.F.), the Austrian Science Fund (FWF; I 3630-B25 to J.F.), Chemical Sciences (partly) financed by the Dutch Research Council (NWO-CW TOP 700.58.301 to R.O.), the Dutch Research Council (NWO-VICI 865.17.002 to R. Pierik), Grants-in-Aid from the Ministry of Education, Culture, Sports, Science and Technology, Japan (KAKENHI grant 17K17595 to S.N.), the Ministry of Education, Youth and Sports of the Czech Republic (MŠMT project NPUI-LO1417 ), and a China Scholarship Council (to X.W.).","status":"public","scopus_import":"1","date_published":"2021-03-10T00:00:00Z","abstract":[{"lang":"eng","text":"Polar subcellular localization of the PIN exporters of the phytohormone auxin is a key determinant of directional, intercellular auxin transport and thus a central topic of both plant cell and developmental biology. Arabidopsis mutants lacking PID, a kinase that phosphorylates PINs, or the MAB4/MEL proteins of unknown molecular function display PIN polarity defects and phenocopy pin mutants, but mechanistic insights into how these factors convey PIN polarity are missing. Here, by combining protein biochemistry with quantitative live-cell imaging, we demonstrate that PINs, MAB4/MELs, and AGC kinases interact in the same complex at the plasma membrane. MAB4/MELs are recruited to the plasma membrane by the PINs and in concert with the AGC kinases maintain PIN polarity through limiting lateral diffusion-based escape of PINs from the polar domain. The PIN-MAB4/MEL-PID protein complex has self-reinforcing properties thanks to positive feedback between AGC kinase-mediated PIN phosphorylation and MAB4/MEL recruitment. We thus uncover the molecular mechanism by which AGC kinases and MAB4/MEL proteins regulate PIN localization and plant development."}]},{"intvolume":"        31","quality_controlled":"1","language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"date_updated":"2026-04-02T13:59:25Z","external_id":{"pmid":["33974865"],"isi":["000654741200004"]},"corr_author":"1","date_created":"2021-05-16T22:01:46Z","department":[{"_id":"NiBa"}],"citation":{"chicago":"Stankowski, Sean, and Mark Ravinet. “Quantifying the Use of Species Concepts.” <i>Current Biology</i>. Cell Press, 2021. <a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">https://doi.org/10.1016/j.cub.2021.03.060</a>.","ama":"Stankowski S, Ravinet M. Quantifying the use of species concepts. <i>Current Biology</i>. 2021;31(9):R428-R429. doi:<a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">10.1016/j.cub.2021.03.060</a>","apa":"Stankowski, S., &#38; Ravinet, M. (2021). Quantifying the use of species concepts. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">https://doi.org/10.1016/j.cub.2021.03.060</a>","ista":"Stankowski S, Ravinet M. 2021. Quantifying the use of species concepts. Current Biology. 31(9), R428–R429.","mla":"Stankowski, Sean, and Mark Ravinet. “Quantifying the Use of Species Concepts.” <i>Current Biology</i>, vol. 31, no. 9, Cell Press, 2021, pp. R428–29, doi:<a href=\"https://doi.org/10.1016/j.cub.2021.03.060\">10.1016/j.cub.2021.03.060</a>.","ieee":"S. Stankowski and M. Ravinet, “Quantifying the use of species concepts,” <i>Current Biology</i>, vol. 31, no. 9. Cell Press, pp. R428–R429, 2021.","short":"S. Stankowski, M. Ravinet, Current Biology 31 (2021) R428–R429."},"volume":31,"page":"R428-R429","publisher":"Cell Press","doi":"10.1016/j.cub.2021.03.060","day":"10","type":"journal_article","publication":"Current Biology","main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2021.03.060","open_access":"1"}],"scopus_import":"1","abstract":[{"text":"Humans conceptualize the diversity of life by classifying individuals into types we call ‘species’1. The species we recognize influence political and financial decisions and guide our understanding of how units of diversity evolve and interact. Although the idea of species may seem intuitive, a debate about the best way to define them has raged even before Darwin2. So much energy has been devoted to the so-called ‘species problem’ that no amount of discourse will ever likely solve it2,3. Dozens of species concepts are currently recognized3, but we lack a concrete understanding of how much researchers actually disagree and the factors that cause them to think differently1,2. To address this, we used a survey to quantify the species problem for the first time. The results indicate that the disagreement is extensive: two randomly chosen respondents will most likely disagree on the nature of species. The probability of disagreement is not predicted by researcher experience or broad study system, but tended to be lower among researchers with similar focus, training and who study the same organism. Should we see this diversity of perspectives as a problem? We argue that we should not.","lang":"eng"}],"date_published":"2021-05-10T00:00:00Z","status":"public","acknowledgement":"We thank Christopher Cooney, Martin Garlovsky, Anja M. Westram, Carina Baskett, Stefanie Belohlavy, Michal Hledik, Arka Pal, Nicholas H. Barton, Roger K. Butlin and members of the University of Sheffield Speciation Journal Club for feedback on draft survey questions and/or comments on a draft manuscript. Three anonymous reviewers gave thoughtful feedback that improved the manuscript. We thank Ahmad Nadeem, who was paid to build the Shiny app. We are especially grateful to everyone who took part in the survey. Ethical approval for the survey was obtained through the University of Sheffield Ethics Review Procedure (Application 029768). S.S. was supported by a NERC grant awarded to Roger K. Butlin.","article_type":"original","publication_status":"published","author":[{"id":"43161670-5719-11EA-8025-FABC3DDC885E","full_name":"Stankowski, Sean","first_name":"Sean","last_name":"Stankowski"},{"full_name":"Ravinet, Mark","first_name":"Mark","last_name":"Ravinet"}],"user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","isi":1,"oa":1,"year":"2021","issue":"9","_id":"9392","oa_version":"Published Version","title":"Quantifying the use of species concepts","article_processing_charge":"No","pmid":1,"month":"05"},{"extern":"1","publication":"Current Biology","publisher":"Elsevier","day":"19","doi":"10.1016/j.cub.2019.06.084","page":"2676-2686.e3","type":"journal_article","citation":{"ista":"Lawrence EJ, Gao H, Tock AJ, Lambing C, Blackwell AR, Feng X, Henderson IR. 2019. Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis. Current Biology. 29(16), 2676–2686.e3.","apa":"Lawrence, E. J., Gao, H., Tock, A. J., Lambing, C., Blackwell, A. R., Feng, X., &#38; Henderson, I. R. (2019). Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">https://doi.org/10.1016/j.cub.2019.06.084</a>","mla":"Lawrence, Emma J., et al. “Natural Variation in TBP-ASSOCIATED FACTOR 4b Controls Meiotic Crossover and Germline Transcription in Arabidopsis.” <i>Current Biology</i>, vol. 29, no. 16, Elsevier, 2019, p. 2676–2686.e3, doi:<a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">10.1016/j.cub.2019.06.084</a>.","ieee":"E. J. Lawrence <i>et al.</i>, “Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis,” <i>Current Biology</i>, vol. 29, no. 16. Elsevier, p. 2676–2686.e3, 2019.","short":"E.J. Lawrence, H. Gao, A.J. Tock, C. Lambing, A.R. Blackwell, X. Feng, I.R. Henderson, Current Biology 29 (2019) 2676–2686.e3.","chicago":"Lawrence, Emma J., Hongbo Gao, Andrew J. Tock, Christophe Lambing, Alexander R. Blackwell, Xiaoqi Feng, and Ian R. Henderson. “Natural Variation in TBP-ASSOCIATED FACTOR 4b Controls Meiotic Crossover and Germline Transcription in Arabidopsis.” <i>Current Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">https://doi.org/10.1016/j.cub.2019.06.084</a>.","ama":"Lawrence EJ, Gao H, Tock AJ, et al. Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis. <i>Current Biology</i>. 2019;29(16):2676-2686.e3. doi:<a href=\"https://doi.org/10.1016/j.cub.2019.06.084\">10.1016/j.cub.2019.06.084</a>"},"volume":29,"date_created":"2023-01-16T09:16:33Z","department":[{"_id":"XiFe"}],"date_updated":"2025-01-14T14:31:02Z","external_id":{"pmid":["31378616"]},"quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        29","publication_identifier":{"issn":["0960-9822"]},"pmid":1,"month":"08","article_processing_charge":"No","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"title":"Natural variation in TBP-ASSOCIATED FACTOR 4b controls meiotic crossover and germline transcription in Arabidopsis","issue":"16","_id":"12190","year":"2019","oa_version":"None","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication_status":"published","article_type":"original","author":[{"last_name":"Lawrence","first_name":"Emma J.","full_name":"Lawrence, Emma J."},{"full_name":"Gao, Hongbo","first_name":"Hongbo","last_name":"Gao"},{"full_name":"Tock, Andrew J.","first_name":"Andrew J.","last_name":"Tock"},{"full_name":"Lambing, Christophe","first_name":"Christophe","last_name":"Lambing"},{"first_name":"Alexander R.","full_name":"Blackwell, Alexander R.","last_name":"Blackwell"},{"first_name":"Xiaoqi","id":"e0164712-22ee-11ed-b12a-d80fcdf35958","full_name":"Feng, Xiaoqi","orcid":"0000-0002-4008-1234","last_name":"Feng"},{"last_name":"Henderson","full_name":"Henderson, Ian R.","first_name":"Ian R."}],"acknowledgement":"We thank Gregory Copenhaver (University of North Carolina), Avraham Levy (The Weizmann Institute), and Scott Poethig (University of Pennsylvania) for FTLs; Piotr Ziolkowski for Col-420/Bur seed; Sureshkumar Balasubramanian\r\n(Monash University) for providing British and Irish Arabidopsis accessions; Mathilde Grelon (INRA, Versailles) for providing the MLH1 antibody; and the Gurdon Institute for access to microscopes. This work was supported by a BBSRC DTP studentship (E.J.L.), European Research Area Network for Coordinating Action in Plant Sciences/BBSRC ‘‘DeCOP’’ (BB/M004937/1; C.L.), a BBSRC David Phillips Fellowship (BB/L025043/1; H.G. and X.F.), the European Research Council (CoG ‘‘SynthHotspot,’’ A.J.T., C.L., and I.R.H.; StG ‘‘SexMeth,’’ X.F.), and a Sainsbury Charitable Foundation Studentship (A.R.B.).","scopus_import":"1","abstract":[{"text":"Meiotic crossover frequency varies within genomes, which influences genetic diversity and adaptation. In turn, genetic variation within populations can act to modify crossover frequency in cis and trans. To identify genetic variation that controls meiotic crossover frequency, we screened Arabidopsis accessions using fluorescent recombination reporters. We mapped a genetic modifier of crossover frequency in Col × Bur populations of Arabidopsis to a premature stop codon within TBP-ASSOCIATED FACTOR 4b (TAF4b), which encodes a subunit of the RNA polymerase II general transcription factor TFIID. The Arabidopsis taf4b mutation is a rare variant found in the British Isles, originating in South-West Ireland. Using genetics, genomics, and immunocytology, we demonstrate a genome-wide decrease in taf4b crossovers, with strongest reduction in the sub-telomeric regions. Using RNA sequencing (RNA-seq) from purified meiocytes, we show that TAF4b expression is meiocyte enriched, whereas its paralog TAF4 is broadly expressed. Consistent with the role of TFIID in promoting gene expression, RNA-seq of wild-type and taf4b meiocytes identified widespread transcriptional changes, including in genes that regulate the meiotic cell cycle and recombination. Therefore, TAF4b duplication is associated with acquisition of meiocyte-specific expression and promotion of germline transcription, which act directly or indirectly to elevate crossovers. This identifies a novel mode of meiotic recombination control via a general transcription factor.","lang":"eng"}],"date_published":"2019-08-19T00:00:00Z","status":"public"},{"article_processing_charge":"No","month":"10","pmid":1,"oa_version":"None","year":"2019","_id":"6979","issue":"20","title":"Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal","author":[{"orcid":"0000-0002-2187-6656","last_name":"Kopf","first_name":"Aglaja","full_name":"Kopf, Aglaja","id":"31DAC7B6-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179"}],"article_type":"original","publication_status":"published","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","isi":1,"status":"public","scopus_import":"1","date_published":"2019-10-21T00:00:00Z","publication":"Current Biology","volume":29,"citation":{"mla":"Kopf, Aglaja, and Michael K. Sixt. “Gut Homeostasis: Active Migration of Intestinal Epithelial Cells in Tissue Renewal.” <i>Current Biology</i>, vol. 29, no. 20, Cell Press, 2019, pp. R1091–93, doi:<a href=\"https://doi.org/10.1016/j.cub.2019.08.068\">10.1016/j.cub.2019.08.068</a>.","ista":"Kopf A, Sixt MK. 2019. Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal. Current Biology. 29(20), R1091–R1093.","apa":"Kopf, A., &#38; Sixt, M. K. (2019). Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2019.08.068\">https://doi.org/10.1016/j.cub.2019.08.068</a>","ieee":"A. Kopf and M. K. Sixt, “Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal,” <i>Current Biology</i>, vol. 29, no. 20. Cell Press, pp. R1091–R1093, 2019.","short":"A. Kopf, M.K. Sixt, Current Biology 29 (2019) R1091–R1093.","chicago":"Kopf, Aglaja, and Michael K Sixt. “Gut Homeostasis: Active Migration of Intestinal Epithelial Cells in Tissue Renewal.” <i>Current Biology</i>. Cell Press, 2019. <a href=\"https://doi.org/10.1016/j.cub.2019.08.068\">https://doi.org/10.1016/j.cub.2019.08.068</a>.","ama":"Kopf A, Sixt MK. Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal. <i>Current Biology</i>. 2019;29(20):R1091-R1093. doi:<a href=\"https://doi.org/10.1016/j.cub.2019.08.068\">10.1016/j.cub.2019.08.068</a>"},"type":"journal_article","page":"R1091-R1093","doi":"10.1016/j.cub.2019.08.068","day":"21","publisher":"Cell Press","department":[{"_id":"MiSi"}],"date_created":"2019-11-04T15:18:29Z","publication_identifier":{"issn":["0960-9822"],"eissn":["1879-0445"]},"intvolume":"        29","quality_controlled":"1","language":[{"iso":"eng"}],"external_id":{"isi":["000491286200016"],"pmid":["31639357"]},"date_updated":"2023-09-05T12:43:43Z"},{"article_processing_charge":"No","pmid":1,"month":"05","_id":"11074","issue":"10","year":"2015","oa_version":"Published Version","keyword":["General Agricultural and Biological Sciences","General Biochemistry","Genetics and Molecular Biology"],"title":"Chromothripsis","publication_status":"published","article_type":"original","author":[{"full_name":"Hatch, Emily M.","first_name":"Emily M.","last_name":"Hatch"},{"first_name":"Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed","full_name":"HETZER, Martin W","last_name":"HETZER","orcid":"0000-0002-2111-992X"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","oa":1,"date_published":"2015-05-18T00:00:00Z","scopus_import":"1","status":"public","publication":"Current Biology","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cub.2015.02.033"}],"extern":"1","citation":{"apa":"Hatch, E. M., &#38; Hetzer, M. (2015). Chromothripsis. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">https://doi.org/10.1016/j.cub.2015.02.033</a>","ista":"Hatch EM, Hetzer M. 2015. Chromothripsis. Current Biology. 25(10), PR397-R399.","mla":"Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” <i>Current Biology</i>, vol. 25, no. 10, Elsevier, 2015, pp. PR397-R399, doi:<a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">10.1016/j.cub.2015.02.033</a>.","ieee":"E. M. Hatch and M. Hetzer, “Chromothripsis,” <i>Current Biology</i>, vol. 25, no. 10. Elsevier, pp. PR397-R399, 2015.","short":"E.M. Hatch, M. Hetzer, Current Biology 25 (2015) PR397-R399.","chicago":"Hatch, Emily M., and Martin Hetzer. “Chromothripsis.” <i>Current Biology</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">https://doi.org/10.1016/j.cub.2015.02.033</a>.","ama":"Hatch EM, Hetzer M. Chromothripsis. <i>Current Biology</i>. 2015;25(10):PR397-R399. doi:<a href=\"https://doi.org/10.1016/j.cub.2015.02.033\">10.1016/j.cub.2015.02.033</a>"},"volume":25,"day":"18","publisher":"Elsevier","doi":"10.1016/j.cub.2015.02.033","page":"PR397-R399","type":"journal_article","date_created":"2022-04-07T07:49:00Z","language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"        25","publication_identifier":{"issn":["0960-9822"]},"date_updated":"2024-10-14T11:22:15Z","external_id":{"pmid":["25989073"]}},{"article_processing_charge":"No","month":"09","pmid":1,"oa_version":"Published Version","_id":"9489","issue":"17","year":"2010","title":"Evolution of eukaryotic DNA methylation and the pursuit of safer sex","author":[{"full_name":"Zemach, Assaf","first_name":"Assaf","last_name":"Zemach"},{"orcid":"0000-0002-0123-8649","last_name":"Zilberman","first_name":"Daniel","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","full_name":"Zilberman, Daniel"}],"publication_status":"published","article_type":"review","oa":1,"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","status":"public","abstract":[{"lang":"eng","text":"Cytosine methylation is an ancient process with conserved enzymology but diverse biological functions that include defense against transposable elements and regulation of gene expression. Here we will discuss the evolution and biological significance of eukaryotic DNA methylation, the likely drivers of that evolution, and major remaining mysteries."}],"scopus_import":"1","date_published":"2010-09-14T00:00:00Z","publication":"Current Biology","main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2010.07.007","open_access":"1"}],"extern":"1","volume":20,"citation":{"short":"A. Zemach, D. Zilberman, Current Biology 20 (2010) R780–R785.","ieee":"A. Zemach and D. Zilberman, “Evolution of eukaryotic DNA methylation and the pursuit of safer sex,” <i>Current Biology</i>, vol. 20, no. 17. Elsevier, pp. R780–R785, 2010.","mla":"Zemach, Assaf, and Daniel Zilberman. “Evolution of Eukaryotic DNA Methylation and the Pursuit of Safer Sex.” <i>Current Biology</i>, vol. 20, no. 17, Elsevier, 2010, pp. R780–85, doi:<a href=\"https://doi.org/10.1016/j.cub.2010.07.007\">10.1016/j.cub.2010.07.007</a>.","apa":"Zemach, A., &#38; Zilberman, D. (2010). Evolution of eukaryotic DNA methylation and the pursuit of safer sex. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2010.07.007\">https://doi.org/10.1016/j.cub.2010.07.007</a>","ista":"Zemach A, Zilberman D. 2010. Evolution of eukaryotic DNA methylation and the pursuit of safer sex. Current Biology. 20(17), R780–R785.","ama":"Zemach A, Zilberman D. Evolution of eukaryotic DNA methylation and the pursuit of safer sex. <i>Current Biology</i>. 2010;20(17):R780-R785. doi:<a href=\"https://doi.org/10.1016/j.cub.2010.07.007\">10.1016/j.cub.2010.07.007</a>","chicago":"Zemach, Assaf, and Daniel Zilberman. “Evolution of Eukaryotic DNA Methylation and the Pursuit of Safer Sex.” <i>Current Biology</i>. Elsevier, 2010. <a href=\"https://doi.org/10.1016/j.cub.2010.07.007\">https://doi.org/10.1016/j.cub.2010.07.007</a>."},"type":"journal_article","doi":"10.1016/j.cub.2010.07.007","day":"14","publisher":"Elsevier","page":"R780-R785","department":[{"_id":"DaZi"}],"date_created":"2021-06-07T09:45:27Z","publication_identifier":{"eissn":["1879-0445"],"issn":["0960-9822"]},"language":[{"iso":"eng"}],"quality_controlled":"1","intvolume":"        20","external_id":{"pmid":["20833323"]},"date_updated":"2021-12-14T08:52:34Z"},{"extern":"1","month":"05","publication":"Current Biology","article_processing_charge":"No","publisher":"Elsevier","doi":"10.1016/j.cub.2008.04.059","day":"20","page":"751-757","type":"journal_article","title":"Environmental heterogeneity generates fluctuating selection on a secondary sexual trait","citation":{"ama":"Robinson MR, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LEB. Environmental heterogeneity generates fluctuating selection on a secondary sexual trait. <i>Current Biology</i>. 2008;18(10):751-757. doi:<a href=\"https://doi.org/10.1016/j.cub.2008.04.059\">10.1016/j.cub.2008.04.059</a>","chicago":"Robinson, Matthew Richard, Jill G. Pilkington, Tim H. Clutton-Brock, Josephine M. Pemberton, and Loeske. E.B. Kruuk. “Environmental Heterogeneity Generates Fluctuating Selection on a Secondary Sexual Trait.” <i>Current Biology</i>. Elsevier, 2008. <a href=\"https://doi.org/10.1016/j.cub.2008.04.059\">https://doi.org/10.1016/j.cub.2008.04.059</a>.","short":"M.R. Robinson, J.G. Pilkington, T.H. Clutton-Brock, J.M. Pemberton, L.E.B. Kruuk, Current Biology 18 (2008) 751–757.","ieee":"M. R. Robinson, J. G. Pilkington, T. H. Clutton-Brock, J. M. Pemberton, and L. E. B. Kruuk, “Environmental heterogeneity generates fluctuating selection on a secondary sexual trait,” <i>Current Biology</i>, vol. 18, no. 10. Elsevier, pp. 751–757, 2008.","ista":"Robinson MR, Pilkington JG, Clutton-Brock TH, Pemberton JM, Kruuk LEB. 2008. Environmental heterogeneity generates fluctuating selection on a secondary sexual trait. Current Biology. 18(10), 751–757.","apa":"Robinson, M. R., Pilkington, J. G., Clutton-Brock, T. H., Pemberton, J. M., &#38; Kruuk, L. E. B. (2008). Environmental heterogeneity generates fluctuating selection on a secondary sexual trait. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2008.04.059\">https://doi.org/10.1016/j.cub.2008.04.059</a>","mla":"Robinson, Matthew Richard, et al. “Environmental Heterogeneity Generates Fluctuating Selection on a Secondary Sexual Trait.” <i>Current Biology</i>, vol. 18, no. 10, Elsevier, 2008, pp. 751–57, doi:<a href=\"https://doi.org/10.1016/j.cub.2008.04.059\">10.1016/j.cub.2008.04.059</a>."},"_id":"7752","issue":"10","year":"2008","oa_version":"None","volume":18,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","date_created":"2020-04-30T11:02:13Z","publication_status":"published","author":[{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813","last_name":"Robinson"},{"first_name":"Jill G.","full_name":"Pilkington, Jill G.","last_name":"Pilkington"},{"last_name":"Clutton-Brock","full_name":"Clutton-Brock, Tim H.","first_name":"Tim H."},{"first_name":"Josephine M.","full_name":"Pemberton, Josephine M.","last_name":"Pemberton"},{"last_name":"Kruuk","full_name":"Kruuk, Loeske. E.B.","first_name":"Loeske. E.B."}],"date_updated":"2021-01-12T08:15:17Z","language":[{"iso":"eng"}],"quality_controlled":"1","date_published":"2008-05-20T00:00:00Z","intvolume":"        18","publication_identifier":{"issn":["0960-9822"]},"status":"public"},{"date_created":"2019-03-21T08:23:24Z","publication_status":"published","author":[{"last_name":"Olofsson","full_name":"Olofsson, Birgitta","first_name":"Birgitta"},{"last_name":"de Bono","orcid":"0000-0001-8347-0443","first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","full_name":"de Bono, Mario"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","intvolume":"        18","date_published":"2008-03-11T00:00:00Z","language":[{"iso":"eng"}],"quality_controlled":"1","publication_identifier":{"issn":["0960-9822"]},"status":"public","date_updated":"2022-08-25T15:03:41Z","external_id":{"pmid":["18334193"]},"publication":"Current Biology","article_processing_charge":"No","pmid":1,"extern":"1","month":"03","year":"2008","issue":"5","_id":"6149","citation":{"chicago":"Olofsson, Birgitta, and Mario de Bono. “Sleep: Dozy Worms and Sleepy Flies.” <i>Current Biology</i>. Elsevier, 2008. <a href=\"https://doi.org/10.1016/j.cub.2008.01.002\">https://doi.org/10.1016/j.cub.2008.01.002</a>.","ama":"Olofsson B, de Bono M. Sleep: dozy worms and sleepy flies. <i>Current Biology</i>. 2008;18(5):R204-R206. doi:<a href=\"https://doi.org/10.1016/j.cub.2008.01.002\">10.1016/j.cub.2008.01.002</a>","ieee":"B. Olofsson and M. de Bono, “Sleep: dozy worms and sleepy flies,” <i>Current Biology</i>, vol. 18, no. 5. Elsevier, pp. R204–R206, 2008.","apa":"Olofsson, B., &#38; de Bono, M. (2008). Sleep: dozy worms and sleepy flies. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2008.01.002\">https://doi.org/10.1016/j.cub.2008.01.002</a>","mla":"Olofsson, Birgitta, and Mario de Bono. “Sleep: Dozy Worms and Sleepy Flies.” <i>Current Biology</i>, vol. 18, no. 5, Elsevier, 2008, pp. R204–06, doi:<a href=\"https://doi.org/10.1016/j.cub.2008.01.002\">10.1016/j.cub.2008.01.002</a>.","ista":"Olofsson B, de Bono M. 2008. Sleep: dozy worms and sleepy flies. Current Biology. 18(5), R204–R206.","short":"B. Olofsson, M. de Bono, Current Biology 18 (2008) R204–R206."},"volume":18,"oa_version":"None","page":"R204-R206","publisher":"Elsevier","doi":"10.1016/j.cub.2008.01.002","day":"11","title":"Sleep: dozy worms and sleepy flies","type":"journal_article"},{"type":"journal_article","title":"Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans","doi":"10.1016/j.cub.2006.11.065","day":"23","publisher":"Elsevier","page":"159-164","oa_version":"None","volume":17,"citation":{"short":"T.L. Gumienny, L.T. MacNeil, H. Wang, M. de Bono, J.L. Wrana, R.W. Padgett, Current Biology 17 (2007) 159–164.","mla":"Gumienny, Tina L., et al. “Glypican LON-2 Is a Conserved Negative Regulator of BMP-like Signaling in Caenorhabditis Elegans.” <i>Current Biology</i>, vol. 17, no. 2, Elsevier, 2007, pp. 159–64, doi:<a href=\"https://doi.org/10.1016/j.cub.2006.11.065\">10.1016/j.cub.2006.11.065</a>.","apa":"Gumienny, T. L., MacNeil, L. T., Wang, H., de Bono, M., Wrana, J. L., &#38; Padgett, R. W. (2007). Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2006.11.065\">https://doi.org/10.1016/j.cub.2006.11.065</a>","ista":"Gumienny TL, MacNeil LT, Wang H, de Bono M, Wrana JL, Padgett RW. 2007. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. Current Biology. 17(2), 159–164.","ieee":"T. L. Gumienny, L. T. MacNeil, H. Wang, M. de Bono, J. L. Wrana, and R. W. Padgett, “Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans,” <i>Current Biology</i>, vol. 17, no. 2. Elsevier, pp. 159–164, 2007.","ama":"Gumienny TL, MacNeil LT, Wang H, de Bono M, Wrana JL, Padgett RW. Glypican LON-2 is a conserved negative regulator of BMP-like signaling in Caenorhabditis elegans. <i>Current Biology</i>. 2007;17(2):159-164. doi:<a href=\"https://doi.org/10.1016/j.cub.2006.11.065\">10.1016/j.cub.2006.11.065</a>","chicago":"Gumienny, Tina L., Lesley T. MacNeil, Huang Wang, Mario de Bono, Jeffrey L. Wrana, and Richard W. Padgett. “Glypican LON-2 Is a Conserved Negative Regulator of BMP-like Signaling in Caenorhabditis Elegans.” <i>Current Biology</i>. Elsevier, 2007. <a href=\"https://doi.org/10.1016/j.cub.2006.11.065\">https://doi.org/10.1016/j.cub.2006.11.065</a>."},"_id":"6150","issue":"2","year":"2007","month":"01","pmid":1,"extern":"1","publication":"Current Biology","external_id":{"pmid":["17240342"]},"date_updated":"2021-01-12T08:06:22Z","status":"public","publication_identifier":{"issn":["0960-9822"]},"quality_controlled":"1","language":[{"iso":"eng"}],"date_published":"2007-01-23T00:00:00Z","intvolume":"        17","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Gumienny, Tina L.","first_name":"Tina L.","last_name":"Gumienny"},{"full_name":"MacNeil, Lesley T.","first_name":"Lesley T.","last_name":"MacNeil"},{"last_name":"Wang","first_name":"Huang","full_name":"Wang, Huang"},{"first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","full_name":"de Bono, Mario","orcid":"0000-0001-8347-0443","last_name":"de Bono"},{"last_name":"Wrana","first_name":"Jeffrey L.","full_name":"Wrana, Jeffrey L."},{"last_name":"Padgett","first_name":"Richard W.","full_name":"Padgett, Richard W."}],"date_created":"2019-03-21T08:44:44Z","publication_status":"published"},{"publisher":"Elsevier","doi":"10.1016/j.cub.2006.03.023","day":"04","page":"649-659","type":"journal_article","title":"Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans","issue":"7","_id":"6152","citation":{"ieee":"C. Rogers, A. Persson, B. Cheung, and M. de Bono, “Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans,” <i>Current Biology</i>, vol. 16, no. 7. Elsevier, pp. 649–659, 2006.","apa":"Rogers, C., Persson, A., Cheung, B., &#38; de Bono, M. (2006). Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2006.03.023\">https://doi.org/10.1016/j.cub.2006.03.023</a>","ista":"Rogers C, Persson A, Cheung B, de Bono M. 2006. Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans. Current Biology. 16(7), 649–659.","mla":"Rogers, Candida, et al. “Behavioral Motifs and Neural Pathways Coordinating O2 Responses and Aggregation in C. Elegans.” <i>Current Biology</i>, vol. 16, no. 7, Elsevier, 2006, pp. 649–59, doi:<a href=\"https://doi.org/10.1016/j.cub.2006.03.023\">10.1016/j.cub.2006.03.023</a>.","short":"C. Rogers, A. Persson, B. Cheung, M. de Bono, Current Biology 16 (2006) 649–659.","chicago":"Rogers, Candida, Annelie Persson, Benny Cheung, and Mario de Bono. “Behavioral Motifs and Neural Pathways Coordinating O2 Responses and Aggregation in C. Elegans.” <i>Current Biology</i>. Elsevier, 2006. <a href=\"https://doi.org/10.1016/j.cub.2006.03.023\">https://doi.org/10.1016/j.cub.2006.03.023</a>.","ama":"Rogers C, Persson A, Cheung B, de Bono M. Behavioral motifs and neural pathways coordinating O2 responses and aggregation in C. elegans. <i>Current Biology</i>. 2006;16(7):649-659. doi:<a href=\"https://doi.org/10.1016/j.cub.2006.03.023\">10.1016/j.cub.2006.03.023</a>"},"year":"2006","oa_version":"None","volume":16,"extern":"1","pmid":1,"month":"04","publication":"Current Biology","date_updated":"2021-01-12T08:06:23Z","external_id":{"pmid":["16581509"]},"date_published":"2006-04-04T00:00:00Z","quality_controlled":"1","language":[{"iso":"eng"}],"intvolume":"        16","publication_identifier":{"issn":["0960-9822"]},"status":"public","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publication_status":"published","date_created":"2019-03-21T09:15:27Z","author":[{"first_name":"Candida","full_name":"Rogers, Candida","last_name":"Rogers"},{"full_name":"Persson, Annelie","first_name":"Annelie","last_name":"Persson"},{"first_name":"Benny","full_name":"Cheung, Benny","last_name":"Cheung"},{"first_name":"Mario","id":"4E3FF80E-F248-11E8-B48F-1D18A9856A87","full_name":"de Bono, Mario","last_name":"de Bono","orcid":"0000-0001-8347-0443"}]}]