[{"status":"public","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"type":"journal_article","publisher":"Cell Press","day":"03","issue":"3","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425"},{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"grant_number":"723-2015","_id":"256FEF10-B435-11E9-9278-68D0E5697425","name":"Molecular Mechanism underlying Salicylic Acid Regulation of Endocytic Trafficking in Arabidopsis"}],"has_accepted_license":"1","date_published":"2020-02-03T00:00:00Z","oa_version":"Published Version","year":"2020","date_updated":"2026-04-28T22:30:46Z","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"381-395.e8","_id":"7427","title":"Salicylic acid targets protein phosphatase 2A to attenuate growth in plants","month":"02","article_processing_charge":"No","citation":{"mla":"Tan, Shutang, et al. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.” <i>Current Biology</i>, vol. 30, no. 3, Cell Press, 2020, p. 381–395.e8, doi:<a href=\"https://doi.org/10.1016/j.cub.2019.11.058\">10.1016/j.cub.2019.11.058</a>.","short":"S. Tan, M.F. Abas, I. Verstraeten, M. Glanc, G. Molnar, J. Hajny, P. Lasák, I. Petřík, E. Russinova, J. Petrášek, O. Novák, J. Pospíšil, J. Friml, Current Biology 30 (2020) 381–395.e8.","ieee":"S. Tan <i>et al.</i>, “Salicylic acid targets protein phosphatase 2A to attenuate growth in plants,” <i>Current Biology</i>, vol. 30, no. 3. Cell Press, p. 381–395.e8, 2020.","apa":"Tan, S., Abas, M. F., Verstraeten, I., Glanc, M., Molnar, G., Hajny, J., … Friml, J. (2020). Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2019.11.058\">https://doi.org/10.1016/j.cub.2019.11.058</a>","ama":"Tan S, Abas MF, Verstraeten I, et al. Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. <i>Current Biology</i>. 2020;30(3):381-395.e8. doi:<a href=\"https://doi.org/10.1016/j.cub.2019.11.058\">10.1016/j.cub.2019.11.058</a>","ista":"Tan S, Abas MF, Verstraeten I, Glanc M, Molnar G, Hajny J, Lasák P, Petřík I, Russinova E, Petrášek J, Novák O, Pospíšil J, Friml J. 2020. Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. Current Biology. 30(3), 381–395.e8.","chicago":"Tan, Shutang, Melinda F Abas, Inge Verstraeten, Matous Glanc, Gergely Molnar, Jakub Hajny, Pavel Lasák, et al. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.” <i>Current Biology</i>. Cell Press, 2020. <a href=\"https://doi.org/10.1016/j.cub.2019.11.058\">https://doi.org/10.1016/j.cub.2019.11.058</a>."},"related_material":{"record":[{"id":"8822","status":"public","relation":"dissertation_contains"}]},"ddc":["580"],"doi":"10.1016/j.cub.2019.11.058","article_type":"original","file":[{"file_name":"2020_CurrentBiology_Tan.pdf","creator":"dernst","date_created":"2020-09-22T09:51:28Z","file_id":"8555","file_size":5360135,"content_type":"application/pdf","checksum":"16f7d51fe28f91c21e4896a2028df40b","date_updated":"2020-09-22T09:51:28Z","success":1,"access_level":"open_access","relation":"main_file"}],"acknowledgement":"We thank Shigeyuki Betsuyaku (University of Tsukuba), Alison Delong (Brown University), Xinnian Dong (Duke University), Dolf Weijers (Wageningen University), Yuelin Zhang (UBC), and Martine Pastuglia (Institut Jean-Pierre Bourgin) for sharing published materials; Jana Riederer for help with cantharidin physiological analysis; David Domjan for help with cloning pET28a-PIN2HL; Qing Lu for help with DARTS; Hana Kozubı´kova´ for technical support on SA derivative synthesis; Zuzana Vondra´ kova´ for technical support with tobacco cells; Lucia Strader (Washington University), Bert De Rybel (Ghent University), Bartel Vanholme (Ghent University), and Lukas Mach (BOKU) for helpful discussions; and bioimaging and life science facilities of IST Austria for continuous support. We gratefully acknowledge the Nottingham Arabidopsis Stock Center (NASC) for providing T-DNA insertional mutants. The DSC and SPR instruments were provided by the EQ-BOKU VIBT GmbH and the BOKU Core Facility for Biomolecular and Cellular Analysis, with help of Irene Schaffner. The research leading to these results has received funding from the European Union’s Horizon 2020 program (ERC grant agreement no. 742985 to J.F.) and the People Programme (Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no. 291734. S.T. was supported by a European Molecular Biology Organization (EMBO) long-term postdoctoral fellowship (ALTF 723-2015). O.N. was supported by the Ministry of Education, Youth and Sports of the Czech Republic (European Regional Development Fund-Project ‘‘Centre for Experimental Plant Biology’’ no. CZ.02.1.01/0.0/0.0/16_019/0000738). J. Pospısil was supported by European Regional Development Fund Project ‘‘Centre for Experimental Plant Biology’’\r\n(no. CZ.02.1.01/0.0/0.0/16_019/0000738). J. Petrasek was supported by EU Operational Programme Prague-Competitiveness (no. CZ.2.16/3.1.00/21519). ","pmid":1,"publication_identifier":{"issn":["09609822"]},"oa":1,"scopus_import":"1","author":[{"id":"2DE75584-F248-11E8-B48F-1D18A9856A87","first_name":"Shutang","last_name":"Tan","full_name":"Tan, Shutang","orcid":"0000-0002-0471-8285"},{"full_name":"Abas, Melinda F","last_name":"Abas","id":"3CFB3B1C-F248-11E8-B48F-1D18A9856A87","first_name":"Melinda F"},{"last_name":"Verstraeten","full_name":"Verstraeten, Inge","id":"362BF7FE-F248-11E8-B48F-1D18A9856A87","first_name":"Inge","orcid":"0000-0001-7241-2328"},{"full_name":"Glanc, Matous","last_name":"Glanc","first_name":"Matous","id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","orcid":"0000-0003-0619-7783"},{"full_name":"Molnar, Gergely","last_name":"Molnar","first_name":"Gergely","id":"34F1AF46-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-2140-7195","first_name":"Jakub","id":"4800CC20-F248-11E8-B48F-1D18A9856A87","full_name":"Hajny, Jakub","last_name":"Hajny"},{"first_name":"Pavel","last_name":"Lasák","full_name":"Lasák, Pavel"},{"last_name":"Petřík","full_name":"Petřík, Ivan","first_name":"Ivan"},{"first_name":"Eugenia","full_name":"Russinova, Eugenia","last_name":"Russinova"},{"full_name":"Petrášek, Jan","last_name":"Petrášek","first_name":"Jan"},{"first_name":"Ondřej","last_name":"Novák","full_name":"Novák, Ondřej"},{"last_name":"Pospíšil","full_name":"Pospíšil, Jiří","first_name":"Jiří"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","first_name":"Jiří"}],"publication":"Current Biology","file_date_updated":"2020-09-22T09:51:28Z","ec_funded":1,"intvolume":"        30","isi":1,"volume":30,"quality_controlled":"1","abstract":[{"text":"Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.","lang":"eng"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"LifeSc"}],"publication_status":"published","external_id":{"pmid":["31956021"],"isi":["000511287900018"]},"department":[{"_id":"JiFr"},{"_id":"EvBe"}],"date_created":"2020-02-02T23:01:00Z","language":[{"iso":"eng"}],"corr_author":"1"},{"quality_controlled":"1","volume":29,"abstract":[{"lang":"eng","text":"When animals become sick, infected cells and an armada of activated immune cells attempt to eliminate the pathogen from the body. Once infectious particles have breached the body's physical barriers of the skin or gut lining, an initially local response quickly escalates into a systemic response, attracting mobile immune cells to the site of infection. These cells complement the initial, unspecific defense with a more specialized, targeted response. This can also provide long-term immune memory and protection against future infection. The cell-autonomous defenses of the infected cells are thus aided by the actions of recruited immune cells. These specialized cells are the most mobile cells in the body, constantly patrolling through the otherwise static tissue to detect incoming pathogens. Such constant immune surveillance means infections are noticed immediately and can be rapidly cleared from the body. Some immune cells also remove infected cells that have succumbed to infection. All this prevents pathogen replication and spread to healthy tissues. Although this may involve the sacrifice of some somatic tissue, this is typically replaced quickly. Particular care is, however, given to the reproductive organs, which should always remain disease free (immune privilege). "}],"publication_status":"published","language":[{"iso":"eng"}],"department":[{"_id":"SyCr"}],"external_id":{"pmid":["31163158"],"isi":["000470902000023"]},"date_created":"2019-06-09T21:59:10Z","oa":1,"publication_identifier":{"issn":["09609822"]},"pmid":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cub.2019.03.035"}],"intvolume":"        29","isi":1,"author":[{"full_name":"Cremer, Sylvia","last_name":"Cremer","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868"}],"publication":"Current Biology","scopus_import":"1","title":"Social immunity in insects","month":"06","_id":"6552","citation":{"ieee":"S. Cremer, “Social immunity in insects,” <i>Current Biology</i>, vol. 29, no. 11. Elsevier, pp. R458–R463, 2019.","mla":"Cremer, Sylvia. “Social Immunity in Insects.” <i>Current Biology</i>, vol. 29, no. 11, Elsevier, 2019, pp. R458–63, doi:<a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">10.1016/j.cub.2019.03.035</a>.","short":"S. Cremer, Current Biology 29 (2019) R458–R463.","chicago":"Cremer, Sylvia. “Social Immunity in Insects.” <i>Current Biology</i>. Elsevier, 2019. <a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">https://doi.org/10.1016/j.cub.2019.03.035</a>.","ista":"Cremer S. 2019. Social immunity in insects. Current Biology. 29(11), R458–R463.","ama":"Cremer S. Social immunity in insects. <i>Current Biology</i>. 2019;29(11):R458-R463. doi:<a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">10.1016/j.cub.2019.03.035</a>","apa":"Cremer, S. (2019). Social immunity in insects. <i>Current Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.cub.2019.03.035\">https://doi.org/10.1016/j.cub.2019.03.035</a>"},"article_processing_charge":"No","doi":"10.1016/j.cub.2019.03.035","article_type":"original","status":"public","day":"03","type":"journal_article","publisher":"Elsevier","issue":"11","oa_version":"Published Version","year":"2019","date_updated":"2023-08-28T09:38:00Z","date_published":"2019-06-03T00:00:00Z","page":"R458-R463","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"article_processing_charge":"No","citation":{"ieee":"J. Müller and M. K. Sixt, “Cell migration: Making the waves,” <i>Current Biology</i>, vol. 27, no. 1. Cell Press, pp. R24–R25, 2017.","short":"J. Müller, M.K. Sixt, Current Biology 27 (2017) R24–R25.","mla":"Müller, Jan, and Michael K. Sixt. “Cell Migration: Making the Waves.” <i>Current Biology</i>, vol. 27, no. 1, Cell Press, 2017, pp. R24–25, doi:<a href=\"https://doi.org/10.1016/j.cub.2016.11.035\">10.1016/j.cub.2016.11.035</a>.","ista":"Müller J, Sixt MK. 2017. Cell migration: Making the waves. Current Biology. 27(1), R24–R25.","chicago":"Müller, Jan, and Michael K Sixt. “Cell Migration: Making the Waves.” <i>Current Biology</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cub.2016.11.035\">https://doi.org/10.1016/j.cub.2016.11.035</a>.","apa":"Müller, J., &#38; Sixt, M. K. (2017). Cell migration: Making the waves. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2016.11.035\">https://doi.org/10.1016/j.cub.2016.11.035</a>","ama":"Müller J, Sixt MK. Cell migration: Making the waves. <i>Current Biology</i>. 2017;27(1):R24-R25. doi:<a href=\"https://doi.org/10.1016/j.cub.2016.11.035\">10.1016/j.cub.2016.11.035</a>"},"_id":"1161","month":"01","title":"Cell migration: Making the waves","article_type":"letter_note","OA_type":"free access","publist_id":"6197","doi":"10.1016/j.cub.2016.11.035","OA_place":"publisher","issue":"1","day":"09","type":"journal_article","publisher":"Cell Press","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"R24 - R25","date_published":"2017-01-09T00:00:00Z","date_updated":"2025-06-26T09:01:10Z","year":"2017","oa_version":"Published Version","abstract":[{"text":"Coordinated changes of cell shape are often the result of the excitable, wave-like dynamics of the actin cytoskeleton. New work shows that, in migrating cells, protrusion waves arise from mechanochemical crosstalk between adhesion sites, membrane tension and the actin protrusive machinery.","lang":"eng"}],"volume":27,"quality_controlled":"1","date_created":"2018-12-11T11:50:29Z","department":[{"_id":"MiSi"}],"external_id":{"isi":["000391902500010"]},"language":[{"iso":"eng"}],"publication_status":"published","main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2016.11.035","open_access":"1"}],"publication_identifier":{"issn":["09609822"]},"oa":1,"scopus_import":"1","publication":"Current Biology","author":[{"last_name":"Müller","full_name":"Müller, Jan","first_name":"Jan","id":"AD07FDB4-0F61-11EA-8158-C4CC64CEAA8D"},{"first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","last_name":"Sixt","orcid":"0000-0002-6620-9179"}],"isi":1,"intvolume":"        27"},{"_id":"674","title":"Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6","month":"05","article_processing_charge":"No","citation":{"ista":"Schwarz J, Bierbaum V, Vaahtomeri K, Hauschild R, Brown M, de Vries I, Leithner AF, Reversat A, Merrin J, Tarrant T, Bollenbach MT, Sixt MK. 2017. Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6. Current Biology. 27(9), 1314–1325.","chicago":"Schwarz, Jan, Veronika Bierbaum, Kari Vaahtomeri, Robert Hauschild, Markus Brown, Ingrid de Vries, Alexander F Leithner, et al. “Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal to Noise Ratio and Dependent on GRK6.” <i>Current Biology</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">https://doi.org/10.1016/j.cub.2017.04.004</a>.","apa":"Schwarz, J., Bierbaum, V., Vaahtomeri, K., Hauschild, R., Brown, M., de Vries, I., … Sixt, M. K. (2017). Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">https://doi.org/10.1016/j.cub.2017.04.004</a>","ama":"Schwarz J, Bierbaum V, Vaahtomeri K, et al. Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6. <i>Current Biology</i>. 2017;27(9):1314-1325. doi:<a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">10.1016/j.cub.2017.04.004</a>","ieee":"J. Schwarz <i>et al.</i>, “Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6,” <i>Current Biology</i>, vol. 27, no. 9. Cell Press, pp. 1314–1325, 2017.","mla":"Schwarz, Jan, et al. “Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal to Noise Ratio and Dependent on GRK6.” <i>Current Biology</i>, vol. 27, no. 9, Cell Press, 2017, pp. 1314–25, doi:<a href=\"https://doi.org/10.1016/j.cub.2017.04.004\">10.1016/j.cub.2017.04.004</a>.","short":"J. Schwarz, V. Bierbaum, K. Vaahtomeri, R. Hauschild, M. Brown, I. de Vries, A.F. Leithner, A. Reversat, J. Merrin, T. Tarrant, M.T. Bollenbach, M.K. Sixt, Current Biology 27 (2017) 1314–1325."},"publist_id":"7050","doi":"10.1016/j.cub.2017.04.004","status":"public","day":"09","type":"journal_article","publisher":"Cell Press","issue":"9","project":[{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734"},{"call_identifier":"FWF","name":"Cytoskeletal force generation and force transduction of migrating leukocytes","grant_number":"Y 564-B12","_id":"25A8E5EA-B435-11E9-9278-68D0E5697425"}],"date_published":"2017-05-09T00:00:00Z","oa_version":"None","year":"2017","date_updated":"2025-09-10T14:26:47Z","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","page":"1314 - 1325","volume":27,"quality_controlled":"1","abstract":[{"text":"Navigation of cells along gradients of guidance cues is a determining step in many developmental and immunological processes. Gradients can either be soluble or immobilized to tissues as demonstrated for the haptotactic migration of dendritic cells (DCs) toward higher concentrations of immobilized chemokine CCL21. To elucidate how gradient characteristics govern cellular response patterns, we here introduce an in vitro system allowing to track migratory responses of DCs to precisely controlled immobilized gradients of CCL21. We find that haptotactic sensing depends on the absolute CCL21 concentration and local steepness of the gradient, consistent with a scenario where DC directionality is governed by the signal-to-noise ratio of CCL21 binding to the receptor CCR7. We find that the conditions for optimal DC guidance are perfectly provided by the CCL21 gradients we measure in vivo. Furthermore, we find that CCR7 signal termination by the G-protein-coupled receptor kinase 6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient sensing in vitro and confirm those observations in vivo. These findings suggest that stable, tissue-bound CCL21 gradients as sustainable “roads” ensure optimal guidance in vivo.","lang":"eng"}],"publication_status":"published","external_id":{"isi":["000400741700021"]},"department":[{"_id":"MiSi"},{"_id":"Bio"},{"_id":"NanoFab"}],"date_created":"2018-12-11T11:47:51Z","corr_author":"1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["09609822"]},"author":[{"id":"346C1EC6-F248-11E8-B48F-1D18A9856A87","first_name":"Jan","full_name":"Schwarz, Jan","last_name":"Schwarz"},{"id":"3FD04378-F248-11E8-B48F-1D18A9856A87","first_name":"Veronika","last_name":"Bierbaum","full_name":"Bierbaum, Veronika"},{"id":"368EE576-F248-11E8-B48F-1D18A9856A87","first_name":"Kari","full_name":"Vaahtomeri, Kari","last_name":"Vaahtomeri","orcid":"0000-0001-7829-3518"},{"last_name":"Hauschild","full_name":"Hauschild, Robert","first_name":"Robert","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9843-3522"},{"id":"3DAB9AFC-F248-11E8-B48F-1D18A9856A87","first_name":"Markus","full_name":"Brown, Markus","last_name":"Brown"},{"last_name":"De Vries","full_name":"De Vries, Ingrid","first_name":"Ingrid","id":"4C7D837E-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-1073-744X","last_name":"Leithner","full_name":"Leithner, Alexander F","id":"3B1B77E4-F248-11E8-B48F-1D18A9856A87","first_name":"Alexander F"},{"orcid":"0000-0003-0666-8928","full_name":"Reversat, Anne","last_name":"Reversat","id":"35B76592-F248-11E8-B48F-1D18A9856A87","first_name":"Anne"},{"last_name":"Merrin","full_name":"Merrin, Jack","id":"4515C308-F248-11E8-B48F-1D18A9856A87","first_name":"Jack","orcid":"0000-0001-5145-4609"},{"full_name":"Tarrant, Teresa","last_name":"Tarrant","first_name":"Teresa"},{"orcid":"0000-0003-4398-476X","first_name":"Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","last_name":"Bollenbach","full_name":"Bollenbach, Tobias"},{"orcid":"0000-0002-6620-9179","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K","last_name":"Sixt"}],"scopus_import":"1","publication":"Current Biology","ec_funded":1,"intvolume":"        27","isi":1},{"oa":1,"publication_identifier":{"issn":["09609822"]},"pmid":1,"file":[{"relation":"main_file","access_level":"open_access","date_updated":"2020-07-14T12:47:54Z","checksum":"e45588b21097b408da6276a3e5eedb2e","content_type":"application/pdf","file_size":1576593,"date_created":"2019-04-17T07:46:40Z","file_id":"6332","file_name":"2017_CurrentBiology_Morris.pdf","creator":"dernst"}],"isi":1,"intvolume":"        27","ec_funded":1,"scopus_import":"1","author":[{"first_name":"Emily","last_name":"Morris","full_name":"Morris, Emily"},{"first_name":"Marcus","last_name":"Griffiths","full_name":"Griffiths, Marcus"},{"first_name":"Agata","full_name":"Golebiowska, Agata","last_name":"Golebiowska"},{"first_name":"Stefan","last_name":"Mairhofer","full_name":"Mairhofer, Stefan"},{"first_name":"Jasmine","last_name":"Burr Hersey","full_name":"Burr Hersey, Jasmine"},{"first_name":"Tatsuaki","full_name":"Goh, Tatsuaki","last_name":"Goh"},{"first_name":"Daniel","id":"49E91952-F248-11E8-B48F-1D18A9856A87","last_name":"Von Wangenheim","full_name":"Von Wangenheim, Daniel","orcid":"0000-0002-6862-1247"},{"full_name":"Atkinson, Brian","last_name":"Atkinson","first_name":"Brian"},{"last_name":"Sturrock","full_name":"Sturrock, Craig","first_name":"Craig"},{"first_name":"Jonathan","last_name":"Lynch","full_name":"Lynch, Jonathan"},{"first_name":"Kris","full_name":"Vissenberg, Kris","last_name":"Vissenberg"},{"first_name":"Karl","full_name":"Ritz, Karl","last_name":"Ritz"},{"first_name":"Darren","full_name":"Wells, Darren","last_name":"Wells"},{"full_name":"Mooney, Sacha","last_name":"Mooney","first_name":"Sacha"},{"full_name":"Bennett, Malcolm","last_name":"Bennett","first_name":"Malcolm"}],"file_date_updated":"2020-07-14T12:47:54Z","publication":"Current Biology","quality_controlled":"1","volume":27,"abstract":[{"text":"Plants are sessile organisms rooted in one place. The soil resources that plants require are often distributed in a highly heterogeneous pattern. To aid foraging, plants have evolved roots whose growth and development are highly responsive to soil signals. As a result, 3D root architecture is shaped by myriad environmental signals to ensure resource capture is optimised and unfavourable environments are avoided. The first signals sensed by newly germinating seeds — gravity and light — direct root growth into the soil to aid seedling establishment. Heterogeneous soil resources, such as water, nitrogen and phosphate, also act as signals that shape 3D root growth to optimise uptake. Root architecture is also modified through biotic interactions that include soil fungi and neighbouring plants. This developmental plasticity results in a ‘custom-made’ 3D root system that is best adapted to forage for resources in each soil environment that a plant colonises.","lang":"eng"}],"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","publication_status":"published","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:48:08Z","department":[{"_id":"JiFr"}],"external_id":{"isi":["000410175200028"],"pmid":["28898665"]},"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","image":"/images/cc_by_nc_nd.png","short":"CC BY-NC-ND (4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode"},"status":"public","issue":"17","publisher":"Cell Press","day":"11","type":"journal_article","date_updated":"2025-09-10T10:57:15Z","year":"2017","oa_version":"Submitted Version","has_accepted_license":"1","project":[{"grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme"}],"date_published":"2017-09-11T00:00:00Z","page":"R919 - R930","user_id":"317138e5-6ab7-11ef-aa6d-ffef3953e345","month":"09","title":"Shaping 3D root system architecture","_id":"722","citation":{"mla":"Morris, Emily, et al. “Shaping 3D Root System Architecture.” <i>Current Biology</i>, vol. 27, no. 17, Cell Press, 2017, pp. R919–30, doi:<a href=\"https://doi.org/10.1016/j.cub.2017.06.043\">10.1016/j.cub.2017.06.043</a>.","short":"E. Morris, M. Griffiths, A. Golebiowska, S. Mairhofer, J. Burr Hersey, T. Goh, D. von Wangenheim, B. Atkinson, C. Sturrock, J. Lynch, K. Vissenberg, K. Ritz, D. Wells, S. Mooney, M. Bennett, Current Biology 27 (2017) R919–R930.","ieee":"E. Morris <i>et al.</i>, “Shaping 3D root system architecture,” <i>Current Biology</i>, vol. 27, no. 17. Cell Press, pp. R919–R930, 2017.","ama":"Morris E, Griffiths M, Golebiowska A, et al. Shaping 3D root system architecture. <i>Current Biology</i>. 2017;27(17):R919-R930. doi:<a href=\"https://doi.org/10.1016/j.cub.2017.06.043\">10.1016/j.cub.2017.06.043</a>","apa":"Morris, E., Griffiths, M., Golebiowska, A., Mairhofer, S., Burr Hersey, J., Goh, T., … Bennett, M. (2017). Shaping 3D root system architecture. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2017.06.043\">https://doi.org/10.1016/j.cub.2017.06.043</a>","chicago":"Morris, Emily, Marcus Griffiths, Agata Golebiowska, Stefan Mairhofer, Jasmine Burr Hersey, Tatsuaki Goh, Daniel von Wangenheim, et al. “Shaping 3D Root System Architecture.” <i>Current Biology</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cub.2017.06.043\">https://doi.org/10.1016/j.cub.2017.06.043</a>.","ista":"Morris E, Griffiths M, Golebiowska A, Mairhofer S, Burr Hersey J, Goh T, von Wangenheim D, Atkinson B, Sturrock C, Lynch J, Vissenberg K, Ritz K, Wells D, Mooney S, Bennett M. 2017. Shaping 3D root system architecture. Current Biology. 27(17), R919–R930."},"article_processing_charge":"No","pubrep_id":"982","ddc":["581"],"publist_id":"6956","doi":"10.1016/j.cub.2017.06.043"},{"publist_id":"6949","doi":"10.1016/j.cub.2017.07.010","month":"09","title":"Coordination of morphogenesis and cell fate specification in development","_id":"728","citation":{"ieee":"C. Chan, C.-P. J. Heisenberg, and T. Hiiragi, “Coordination of morphogenesis and cell fate specification in development,” <i>Current Biology</i>, vol. 27, no. 18. Cell Press, pp. R1024–R1035, 2017.","short":"C. Chan, C.-P.J. Heisenberg, T. Hiiragi, Current Biology 27 (2017) R1024–R1035.","mla":"Chan, Chii, et al. “Coordination of Morphogenesis and Cell Fate Specification in Development.” <i>Current Biology</i>, vol. 27, no. 18, Cell Press, 2017, pp. R1024–35, doi:<a href=\"https://doi.org/10.1016/j.cub.2017.07.010\">10.1016/j.cub.2017.07.010</a>.","ista":"Chan C, Heisenberg C-PJ, Hiiragi T. 2017. Coordination of morphogenesis and cell fate specification in development. Current Biology. 27(18), R1024–R1035.","chicago":"Chan, Chii, Carl-Philipp J Heisenberg, and Takashi Hiiragi. “Coordination of Morphogenesis and Cell Fate Specification in Development.” <i>Current Biology</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cub.2017.07.010\">https://doi.org/10.1016/j.cub.2017.07.010</a>.","apa":"Chan, C., Heisenberg, C.-P. J., &#38; Hiiragi, T. (2017). Coordination of morphogenesis and cell fate specification in development. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2017.07.010\">https://doi.org/10.1016/j.cub.2017.07.010</a>","ama":"Chan C, Heisenberg C-PJ, Hiiragi T. Coordination of morphogenesis and cell fate specification in development. <i>Current Biology</i>. 2017;27(18):R1024-R1035. doi:<a href=\"https://doi.org/10.1016/j.cub.2017.07.010\">10.1016/j.cub.2017.07.010</a>"},"article_processing_charge":"No","date_updated":"2023-09-28T11:33:21Z","oa_version":"None","year":"2017","date_published":"2017-09-18T00:00:00Z","page":"R1024 - R1035","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","status":"public","issue":"18","type":"journal_article","day":"18","publisher":"Cell Press","publication_status":"published","language":[{"iso":"eng"}],"date_created":"2018-12-11T11:48:11Z","external_id":{"isi":["000411581800019"]},"department":[{"_id":"CaHe"}],"quality_controlled":"1","volume":27,"abstract":[{"lang":"eng","text":"During animal development, cell-fate-specific changes in gene expression can modify the material properties of a tissue and drive tissue morphogenesis. While mechanistic insights into the genetic control of tissue-shaping events are beginning to emerge, how tissue morphogenesis and mechanics can reciprocally impact cell-fate specification remains relatively unexplored. Here we review recent findings reporting how multicellular morphogenetic events and their underlying mechanical forces can feed back into gene regulatory pathways to specify cell fate. We further discuss emerging techniques that allow for the direct measurement and manipulation of mechanical signals in vivo, offering unprecedented access to study mechanotransduction during development. Examination of the mechanical control of cell fate during tissue morphogenesis will pave the way to an integrated understanding of the design principles that underlie robust tissue patterning in embryonic development."}],"isi":1,"intvolume":"        27","author":[{"last_name":"Chan","full_name":"Chan, Chii","first_name":"Chii"},{"full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566"},{"full_name":"Hiiragi, Takashi","last_name":"Hiiragi","first_name":"Takashi"}],"scopus_import":"1","publication":"Current Biology","publication_identifier":{"issn":["09609822"]}},{"publist_id":"6905","doi":"10.1016/j.cub.2017.10.001","ddc":["570","576"],"pubrep_id":"875","article_processing_charge":"No","citation":{"mla":"Matsubayashi, Yutaka, et al. “A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation.” <i>Current Biology</i>, vol. 27, no. 22, Cell Press, 2017, p. 3526–3534e.4, doi:<a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">10.1016/j.cub.2017.10.001</a>.","short":"Y. Matsubayashi, A. Louani, A. Dragu, B. Sanchez Sanchez, E. Serna Morales, L. Yolland, A. György, G. Vizcay, R. Fleck, J. Heddleston, T. Chew, D.E. Siekhaus, B. Stramer, Current Biology 27 (2017) 3526–3534e.4.","ieee":"Y. Matsubayashi <i>et al.</i>, “A moving source of matrix components is essential for De Novo basement membrane formation,” <i>Current Biology</i>, vol. 27, no. 22. Cell Press, p. 3526–3534e.4, 2017.","apa":"Matsubayashi, Y., Louani, A., Dragu, A., Sanchez Sanchez, B., Serna Morales, E., Yolland, L., … Stramer, B. (2017). A moving source of matrix components is essential for De Novo basement membrane formation. <i>Current Biology</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">https://doi.org/10.1016/j.cub.2017.10.001</a>","ama":"Matsubayashi Y, Louani A, Dragu A, et al. A moving source of matrix components is essential for De Novo basement membrane formation. <i>Current Biology</i>. 2017;27(22):3526-3534e.4. doi:<a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">10.1016/j.cub.2017.10.001</a>","ista":"Matsubayashi Y, Louani A, Dragu A, Sanchez Sanchez B, Serna Morales E, Yolland L, György A, Vizcay G, Fleck R, Heddleston J, Chew T, Siekhaus DE, Stramer B. 2017. A moving source of matrix components is essential for De Novo basement membrane formation. Current Biology. 27(22), 3526–3534e.4.","chicago":"Matsubayashi, Yutaka, Adam Louani, Anca Dragu, Besaiz Sanchez Sanchez, Eduardo Serna Morales, Lawrence Yolland, Attila György, et al. “A Moving Source of Matrix Components Is Essential for De Novo Basement Membrane Formation.” <i>Current Biology</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.cub.2017.10.001\">https://doi.org/10.1016/j.cub.2017.10.001</a>."},"_id":"751","title":"A moving source of matrix components is essential for De Novo basement membrane formation","month":"11","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","page":"3526 - 3534e.4","has_accepted_license":"1","date_published":"2017-11-09T00:00:00Z","year":"2017","oa_version":"Published Version","date_updated":"2023-09-27T12:25:31Z","day":"09","type":"journal_article","publisher":"Cell Press","issue":"22","status":"public","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"department":[{"_id":"DaSi"}],"external_id":{"isi":["000415815800031"]},"date_created":"2018-12-11T11:48:18Z","language":[{"iso":"eng"}],"publication_status":"published","abstract":[{"text":"The basement membrane (BM) is a thin layer of extracellular matrix (ECM) beneath nearly all epithelial cell types that is critical for cellular and tissue function. It is composed of numerous components conserved among all bilaterians [1]; however, it is unknown how all of these components are generated and subsequently constructed to form a fully mature BM in the living animal. Although BM formation is thought to simply involve a process of self-assembly [2], this concept suffers from a number of logistical issues when considering its construction in vivo. First, incorporation of BM components appears to be hierarchical [3-5], yet it is unclear whether their production during embryogenesis must also be regulated in a temporal fashion. Second, many BM proteins are produced not only by the cells residing on the BM but also by surrounding cell types [6-9], and it is unclear how large, possibly insoluble protein complexes [10] are delivered into the matrix. Here we exploit our ability to live image and genetically dissect de novo BM formation during Drosophila development. This reveals that there is a temporal hierarchy of BM protein production that is essential for proper component incorporation. Furthermore, we show that BM components require secretion by migrating macrophages (hemocytes) during their developmental dispersal, which is critical for embryogenesis. Indeed, hemocyte migration is essential to deliver a subset of ECM components evenly throughout the embryo. This reveals that de novo BM construction requires a combination of both production and distribution logistics allowing for the timely delivery of core components.","lang":"eng"}],"volume":27,"quality_controlled":"1","file_date_updated":"2020-07-14T12:47:59Z","publication":"Current Biology","scopus_import":"1","author":[{"last_name":"Matsubayashi","full_name":"Matsubayashi, Yutaka","first_name":"Yutaka"},{"full_name":"Louani, Adam","last_name":"Louani","first_name":"Adam"},{"full_name":"Dragu, Anca","last_name":"Dragu","first_name":"Anca"},{"last_name":"Sanchez Sanchez","full_name":"Sanchez Sanchez, Besaiz","first_name":"Besaiz"},{"first_name":"Eduardo","full_name":"Serna Morales, Eduardo","last_name":"Serna Morales"},{"last_name":"Yolland","full_name":"Yolland, Lawrence","first_name":"Lawrence"},{"full_name":"György, Attila","last_name":"György","first_name":"Attila","id":"3BCEDBE0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-1819-198X"},{"full_name":"Vizcay, Gema","last_name":"Vizcay","first_name":"Gema"},{"first_name":"Roland","full_name":"Fleck, Roland","last_name":"Fleck"},{"first_name":"John","full_name":"Heddleston, John","last_name":"Heddleston"},{"full_name":"Chew, Teng","last_name":"Chew","first_name":"Teng"},{"id":"3D224B9E-F248-11E8-B48F-1D18A9856A87","first_name":"Daria E","last_name":"Siekhaus","full_name":"Siekhaus, Daria E","orcid":"0000-0001-8323-8353"},{"last_name":"Stramer","full_name":"Stramer, Brian","first_name":"Brian"}],"intvolume":"        27","isi":1,"file":[{"relation":"main_file","access_level":"open_access","file_size":4770657,"file_id":"4770","date_created":"2018-12-12T10:09:45Z","creator":"system","file_name":"IST-2017-875-v1+1_1-s2.0-S0960982217312691-main.pdf","date_updated":"2020-07-14T12:47:59Z","content_type":"application/pdf","checksum":"264cf6c6c3551486ba5ea786850e000a"}],"publication_identifier":{"issn":["09609822"]},"oa":1}]