[{"publication_identifier":{"issn":["1399-0047"]},"article_type":"original","has_accepted_license":"1","year":"2015","month":"10","date_created":"2026-01-29T21:56:58Z","OA_type":"closed access","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2026-02-23T09:09:14Z","title":"The novel double-folded structure of d(GCATGCATGC): A possible model for triplet-repeat sequences","author":[{"last_name":"Thirugnanasambandam","first_name":"Arunachalam","full_name":"Thirugnanasambandam, Arunachalam"},{"full_name":"Karthik, Selvam","first_name":"Selvam","last_name":"Karthik"},{"first_name":"Pradeep K","full_name":"Mandal, Pradeep K","last_name":"Mandal","id":"6a3def15-d4b4-11ef-9fa9-a24c1f545ec3","orcid":"0000-0001-5996-956X"},{"last_name":"Gautham","full_name":"Gautham, Namasivayam","first_name":"Namasivayam"}],"oa_version":"None","doi":"10.1107/s1399004715013930","page":"2119-2126","publisher":"International Union of Crystallography","_id":"21103","article_processing_charge":"No","issue":"10","publication_status":"published","publication":"Acta Crystallographica Section D Structural Biology","extern":"1","language":[{"iso":"eng"}],"quality_controlled":"1","abstract":[{"text":"The structure of the decadeoxyribonucleotide d(GCATGCATGC) is presented at a resolution of 1.8 Å. The decamer adopts a novel double-folded structure in which the direction of progression of the backbone changes at the two thymine residues. Intra-strand stacking interactions (including an interaction between the endocylic O atom of a ribose moiety and the adjacent purine base), hydrogen bonds and cobalt-ion interactions stabilize the double-folded structure of the single strand. Two such double-folded strands come together in the crystal to form a dimer. Inter-strand Watson–Crick hydrogen bonds form four base pairs. This portion of the decamer structure is similar to that observed in other previously reported oligonucleotide structures and has been dubbed a `bi-loop'. Both the double-folded single-strand structure, as well as the dimeric bi-loop structure, serve as starting points to construct models for triplet-repeat DNA sequences, which have been implicated in many human diseases.","lang":"eng"}],"volume":71,"citation":{"ista":"Thirugnanasambandam A, Karthik S, Mandal PK, Gautham N. 2015. The novel double-folded structure of d(GCATGCATGC): A possible model for triplet-repeat sequences. Acta Crystallographica Section D Structural Biology. 71(10), 2119–2126.","apa":"Thirugnanasambandam, A., Karthik, S., Mandal, P. K., &#38; Gautham, N. (2015). The novel double-folded structure of d(GCATGCATGC): A possible model for triplet-repeat sequences. <i>Acta Crystallographica Section D Structural Biology</i>. International Union of Crystallography. <a href=\"https://doi.org/10.1107/s1399004715013930\">https://doi.org/10.1107/s1399004715013930</a>","chicago":"Thirugnanasambandam, Arunachalam, Selvam Karthik, Pradeep K Mandal, and Namasivayam Gautham. “The Novel Double-Folded Structure of d(GCATGCATGC): A Possible Model for Triplet-Repeat Sequences.” <i>Acta Crystallographica Section D Structural Biology</i>. International Union of Crystallography, 2015. <a href=\"https://doi.org/10.1107/s1399004715013930\">https://doi.org/10.1107/s1399004715013930</a>.","mla":"Thirugnanasambandam, Arunachalam, et al. “The Novel Double-Folded Structure of d(GCATGCATGC): A Possible Model for Triplet-Repeat Sequences.” <i>Acta Crystallographica Section D Structural Biology</i>, vol. 71, no. 10, International Union of Crystallography, 2015, pp. 2119–26, doi:<a href=\"https://doi.org/10.1107/s1399004715013930\">10.1107/s1399004715013930</a>.","short":"A. Thirugnanasambandam, S. Karthik, P.K. Mandal, N. Gautham, Acta Crystallographica Section D Structural Biology 71 (2015) 2119–2126.","ama":"Thirugnanasambandam A, Karthik S, Mandal PK, Gautham N. The novel double-folded structure of d(GCATGCATGC): A possible model for triplet-repeat sequences. <i>Acta Crystallographica Section D Structural Biology</i>. 2015;71(10):2119-2126. doi:<a href=\"https://doi.org/10.1107/s1399004715013930\">10.1107/s1399004715013930</a>","ieee":"A. Thirugnanasambandam, S. Karthik, P. K. Mandal, and N. Gautham, “The novel double-folded structure of d(GCATGCATGC): A possible model for triplet-repeat sequences,” <i>Acta Crystallographica Section D Structural Biology</i>, vol. 71, no. 10. International Union of Crystallography, pp. 2119–2126, 2015."},"status":"public","day":"01","date_published":"2015-10-01T00:00:00Z","type":"journal_article","intvolume":"        71"}]