---
_id: '12925'
abstract:
- lang: eng
  text: Normal function of organs and cells is tightly linked to the cytoarchitecture.
    Control of the cell volume is therefore vital for the organism. A widely established
    strategy of cells to counteract swelling is the activation of chloride and potassium
    channels, which leads to a net efflux of salt followed by water - a process termed
    regulatory volume decrease. Since there is evidence for swelling-dependent chloride
    channels (IClswell) being activated also during pathological processes, the identification
    of the molecular entity underlying IClswell is of utmost importance. Several proteins
    are discussed as the channel forming IClswell, i.e. phospholemman, p-glycoprotein,
    CLC-3 and ICln. In this review we would like to focus on the properties of ICln,
    a protein cloned from a Madin Darby canine kidney (MDCK) cell library whose expression
    in Xenopus laevis oocytes resulted in a nucleotide sensitive outwardly rectifying
    chloride current closely resembling the biophysical properties of IClswell.
article_processing_charge: No
article_type: original
author:
- first_name: Johannes
  full_name: Fürst, Johannes
  last_name: Fürst
- first_name: Martin
  full_name: Jakab, Martin
  last_name: Jakab
- first_name: Matthias
  full_name: König, Matthias
  last_name: König
- first_name: Markus
  full_name: Ritter, Markus
  last_name: Ritter
- first_name: Martin
  full_name: Gschwentner, Martin
  last_name: Gschwentner
- first_name: Jakob
  full_name: Rudzki, Jakob
  last_name: Rudzki
- first_name: Johann G
  full_name: Danzl, Johann G
  id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
  last_name: Danzl
  orcid: 0000-0001-8559-3973
- first_name: Michael
  full_name: Mayer, Michael
  last_name: Mayer
- first_name: Carmen M.
  full_name: Burtscher, Carmen M.
  last_name: Burtscher
- first_name: Julia
  full_name: Schirmer, Julia
  last_name: Schirmer
- first_name: Brigitte
  full_name: Maier, Brigitte
  last_name: Maier
- first_name: Manfred
  full_name: Nairz, Manfred
  last_name: Nairz
- first_name: Sabine
  full_name: Chwatal, Sabine
  last_name: Chwatal
- first_name: Markus
  full_name: Paulmichl, Markus
  last_name: Paulmichl
citation:
  ama: Fürst J, Jakab M, König M, et al. Structure and Function of the Ion Channel
    ICln. <i>Cellular Physiology and Biochemistry</i>. 2000;10(5-6):329-334. doi:<a
    href="https://doi.org/10.1159/000016374">10.1159/000016374</a>
  apa: Fürst, J., Jakab, M., König, M., Ritter, M., Gschwentner, M., Rudzki, J., …
    Paulmichl, M. (2000). Structure and Function of the Ion Channel ICln. <i>Cellular
    Physiology and Biochemistry</i>. S. Karger AG. <a href="https://doi.org/10.1159/000016374">https://doi.org/10.1159/000016374</a>
  chicago: Fürst, Johannes, Martin Jakab, Matthias König, Markus Ritter, Martin Gschwentner,
    Jakob Rudzki, Johann G Danzl, et al. “Structure and Function of the Ion Channel
    ICln.” <i>Cellular Physiology and Biochemistry</i>. S. Karger AG, 2000. <a href="https://doi.org/10.1159/000016374">https://doi.org/10.1159/000016374</a>.
  ieee: J. Fürst <i>et al.</i>, “Structure and Function of the Ion Channel ICln,”
    <i>Cellular Physiology and Biochemistry</i>, vol. 10, no. 5–6. S. Karger AG, pp.
    329–334, 2000.
  ista: Fürst J, Jakab M, König M, Ritter M, Gschwentner M, Rudzki J, Danzl JG, Mayer
    M, Burtscher CM, Schirmer J, Maier B, Nairz M, Chwatal S, Paulmichl M. 2000. Structure
    and Function of the Ion Channel ICln. Cellular Physiology and Biochemistry. 10(5–6),
    329–334.
  mla: Fürst, Johannes, et al. “Structure and Function of the Ion Channel ICln.” <i>Cellular
    Physiology and Biochemistry</i>, vol. 10, no. 5–6, S. Karger AG, 2000, pp. 329–34,
    doi:<a href="https://doi.org/10.1159/000016374">10.1159/000016374</a>.
  short: J. Fürst, M. Jakab, M. König, M. Ritter, M. Gschwentner, J. Rudzki, J.G.
    Danzl, M. Mayer, C.M. Burtscher, J. Schirmer, B. Maier, M. Nairz, S. Chwatal,
    M. Paulmichl, Cellular Physiology and Biochemistry 10 (2000) 329–334.
date_created: 2023-05-08T09:04:58Z
date_published: 2000-01-01T00:00:00Z
date_updated: 2023-05-08T10:07:10Z
doi: 10.1159/000016374
extern: '1'
external_id:
  pmid:
  - '11125213'
intvolume: '        10'
issue: 5-6
keyword:
- Physiology
language:
- iso: eng
oa_version: None
page: 329-334
pmid: 1
publication: Cellular Physiology and Biochemistry
publication_identifier:
  issn:
  - 1015-8987
  - 1421-9778
publication_status: published
publisher: S. Karger AG
quality_controlled: '1'
scopus_import: '1'
status: public
title: Structure and Function of the Ion Channel ICln
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 10
year: '2000'
...