---
_id: '7476'
abstract:
- lang: eng
  text: The sebaceous gland (SG) is an essential component of the skin, and SG dysfunction
    is debilitating1,2. Yet, the cellular bases for its origin, development and subsequent
    maintenance remain poorly understood. Here, we apply large-scale quantitative
    fate mapping to define the patterns of cell fate behaviour during SG development
    and maintenance. We show that the SG develops from a defined number of lineage-restricted
    progenitors that undergo a programme of independent and stochastic cell fate decisions.
    Following an expansion phase, equipotent progenitors transition into a phase of
    homeostatic turnover, which is correlated with changes in the mechanical properties
    of the stroma and spatial restrictions on gland size. Expression of the oncogene
    KrasG12D results in a release from these constraints and unbridled gland expansion.
    Quantitative clonal fate analysis reveals that, during this phase, the primary
    effect of the Kras oncogene is to drive a constant fate bias with little effect
    on cell division rates. These findings provide insight into the developmental
    programme of the SG, as well as the mechanisms that drive tumour progression and
    gland dysfunction.
article_processing_charge: No
article_type: original
author:
- first_name: Marianne Stemann
  full_name: Andersen, Marianne Stemann
  last_name: Andersen
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Svetlana
  full_name: Ulyanchenko, Svetlana
  last_name: Ulyanchenko
- first_name: Soline
  full_name: Estrach, Soline
  last_name: Estrach
- first_name: Yasuko
  full_name: Antoku, Yasuko
  last_name: Antoku
- first_name: Sabrina
  full_name: Pisano, Sabrina
  last_name: Pisano
- first_name: Kim E.
  full_name: Boonekamp, Kim E.
  last_name: Boonekamp
- first_name: Sarah
  full_name: Sendrup, Sarah
  last_name: Sendrup
- first_name: Martti
  full_name: Maimets, Martti
  last_name: Maimets
- first_name: Marianne Terndrup
  full_name: Pedersen, Marianne Terndrup
  last_name: Pedersen
- first_name: Jens V.
  full_name: Johansen, Jens V.
  last_name: Johansen
- first_name: Ditte L.
  full_name: Clement, Ditte L.
  last_name: Clement
- first_name: Chloe C.
  full_name: Feral, Chloe C.
  last_name: Feral
- first_name: Benjamin D.
  full_name: Simons, Benjamin D.
  last_name: Simons
- first_name: Kim B.
  full_name: Jensen, Kim B.
  last_name: Jensen
citation:
  ama: Andersen MS, Hannezo EB, Ulyanchenko S, et al. Tracing the cellular dynamics
    of sebaceous gland development in normal and perturbed states. <i>Nature Cell
    Biology</i>. 2019;21(8):924-932. doi:<a href="https://doi.org/10.1038/s41556-019-0362-x">10.1038/s41556-019-0362-x</a>
  apa: Andersen, M. S., Hannezo, E. B., Ulyanchenko, S., Estrach, S., Antoku, Y.,
    Pisano, S., … Jensen, K. B. (2019). Tracing the cellular dynamics of sebaceous
    gland development in normal and perturbed states. <i>Nature Cell Biology</i>.
    Springer Nature. <a href="https://doi.org/10.1038/s41556-019-0362-x">https://doi.org/10.1038/s41556-019-0362-x</a>
  chicago: Andersen, Marianne Stemann, Edouard B Hannezo, Svetlana Ulyanchenko, Soline
    Estrach, Yasuko Antoku, Sabrina Pisano, Kim E. Boonekamp, et al. “Tracing the
    Cellular Dynamics of Sebaceous Gland Development in Normal and Perturbed States.”
    <i>Nature Cell Biology</i>. Springer Nature, 2019. <a href="https://doi.org/10.1038/s41556-019-0362-x">https://doi.org/10.1038/s41556-019-0362-x</a>.
  ieee: M. S. Andersen <i>et al.</i>, “Tracing the cellular dynamics of sebaceous
    gland development in normal and perturbed states,” <i>Nature Cell Biology</i>,
    vol. 21, no. 8. Springer Nature, pp. 924–932, 2019.
  ista: Andersen MS, Hannezo EB, Ulyanchenko S, Estrach S, Antoku Y, Pisano S, Boonekamp
    KE, Sendrup S, Maimets M, Pedersen MT, Johansen JV, Clement DL, Feral CC, Simons
    BD, Jensen KB. 2019. Tracing the cellular dynamics of sebaceous gland development
    in normal and perturbed states. Nature Cell Biology. 21(8), 924–932.
  mla: Andersen, Marianne Stemann, et al. “Tracing the Cellular Dynamics of Sebaceous
    Gland Development in Normal and Perturbed States.” <i>Nature Cell Biology</i>,
    vol. 21, no. 8, Springer Nature, 2019, pp. 924–32, doi:<a href="https://doi.org/10.1038/s41556-019-0362-x">10.1038/s41556-019-0362-x</a>.
  short: M.S. Andersen, E.B. Hannezo, S. Ulyanchenko, S. Estrach, Y. Antoku, S. Pisano,
    K.E. Boonekamp, S. Sendrup, M. Maimets, M.T. Pedersen, J.V. Johansen, D.L. Clement,
    C.C. Feral, B.D. Simons, K.B. Jensen, Nature Cell Biology 21 (2019) 924–932.
date_created: 2020-02-11T08:43:49Z
date_published: 2019-08-01T00:00:00Z
date_updated: 2021-01-12T08:13:47Z
day: '01'
doi: 10.1038/s41556-019-0362-x
extern: '1'
external_id:
  pmid:
  - '31358966'
intvolume: '        21'
issue: '8'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6978139/
month: '08'
oa: 1
oa_version: Submitted Version
page: 924-932
pmid: 1
publication: Nature Cell Biology
publication_identifier:
  issn:
  - 1465-7392
  - 1476-4679
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Tracing the cellular dynamics of sebaceous gland development in normal and
  perturbed states
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2019'
...