---
OA_type: closed access
_id: '21152'
abstract:
- lang: eng
  text: 'Phospholipase A2 (PLA2) is one of the rate limiting enzymes involved in the
    production of arachidonic acid, a potent inflammatory mediator. PLA2 is widely
    distributed all over the animal kingdom. It is also seen in inflammatory exudation
    and venoms of different organisms. The studies demonstrated that PLA2 inhibitors
    have broad spectrum activities that they can either be used against inflammation
    or envenomation. In this study, the inhibitory activity of 1-napthaleneacetic
    acid (NAA) against porcine pancreatic PLA2 has been explained through isothermal
    titration calorimetry and enzyme kinetics studies. The atomic level of interactions
    of NAA with PLA2 was also studied using X-ray crystallography. Apart from these
    findings, the theoretical binding affinities and mode of interactions of two naphthalene-based
    NSAIDs such as naproxen (NAP) and nabumetone (NAB) were studied through molecular
    modeling. The studies proved that the selected ligands are binding at the doorway
    of the active site cleft and hindering the substrate entry to the active site.
    The study brings out a potential scaffold for the designing of broad spectrum
    PLA2 inhibitors which can be used for inflammation or envenomation. '
article_processing_charge: No
article_type: original
author:
- first_name: Kalarickal V.
  full_name: Dileep, Kalarickal V.
  last_name: Dileep
- first_name: Chandran
  full_name: Remya, Chandran
  last_name: Remya
- first_name: Ignatius
  full_name: Tintu, Ignatius
  last_name: Tintu
- first_name: Pradeep K
  full_name: Mandal, Pradeep K
  id: 6a3def15-d4b4-11ef-9fa9-a24c1f545ec3
  last_name: Mandal
  orcid: 0000-0001-5996-956X
- first_name: Ponnuraj
  full_name: Karthe, Ponnuraj
  last_name: Karthe
- first_name: Madathilkovilakathu
  full_name: Haridas, Madathilkovilakathu
  last_name: Haridas
- first_name: Chittalakkottu
  full_name: Sadasivan, Chittalakkottu
  last_name: Sadasivan
citation:
  ama: Dileep KV, Remya C, Tintu I, et al. Crystal structure of phospholipase A2 in
    complex with 1‐naphthaleneacetic acid. <i>IUBMB Life</i>. 2018;70(10):995-1001.
    doi:<a href="https://doi.org/10.1002/iub.1924">10.1002/iub.1924</a>
  apa: Dileep, K. V., Remya, C., Tintu, I., Mandal, P. K., Karthe, P., Haridas, M.,
    &#38; Sadasivan, C. (2018). Crystal structure of phospholipase A2 in complex with
    1‐naphthaleneacetic acid. <i>IUBMB Life</i>. Wiley. <a href="https://doi.org/10.1002/iub.1924">https://doi.org/10.1002/iub.1924</a>
  chicago: Dileep, Kalarickal V., Chandran Remya, Ignatius Tintu, Pradeep K Mandal,
    Ponnuraj Karthe, Madathilkovilakathu Haridas, and Chittalakkottu Sadasivan. “Crystal
    Structure of Phospholipase A2 in Complex with 1‐naphthaleneacetic Acid.” <i>IUBMB
    Life</i>. Wiley, 2018. <a href="https://doi.org/10.1002/iub.1924">https://doi.org/10.1002/iub.1924</a>.
  ieee: K. V. Dileep <i>et al.</i>, “Crystal structure of phospholipase A2 in complex
    with 1‐naphthaleneacetic acid,” <i>IUBMB Life</i>, vol. 70, no. 10. Wiley, pp.
    995–1001, 2018.
  ista: Dileep KV, Remya C, Tintu I, Mandal PK, Karthe P, Haridas M, Sadasivan C.
    2018. Crystal structure of phospholipase A2 in complex with 1‐naphthaleneacetic
    acid. IUBMB Life. 70(10), 995–1001.
  mla: Dileep, Kalarickal V., et al. “Crystal Structure of Phospholipase A2 in Complex
    with 1‐naphthaleneacetic Acid.” <i>IUBMB Life</i>, vol. 70, no. 10, Wiley, 2018,
    pp. 995–1001, doi:<a href="https://doi.org/10.1002/iub.1924">10.1002/iub.1924</a>.
  short: K.V. Dileep, C. Remya, I. Tintu, P.K. Mandal, P. Karthe, M. Haridas, C. Sadasivan,
    IUBMB Life 70 (2018) 995–1001.
date_created: 2026-02-06T12:12:20Z
date_published: 2018-10-01T00:00:00Z
date_updated: 2026-02-20T08:09:53Z
day: '01'
doi: 10.1002/iub.1924
extern: '1'
external_id:
  pmid:
  - '30120882'
fulldoi: https://doi.org/10.1002/iub.1924
has_accepted_license: '1'
intvolume: '        70'
issue: '10'
language:
- iso: eng
month: '10'
oa_version: None
page: 995-1001
pmid: 1
publication: IUBMB Life
publication_identifier:
  eissn:
  - 1521-6551
  issn:
  - 1521-6543
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Crystal structure of phospholipase A2 in complex with 1‐naphthaleneacetic acid
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 70
year: '2018'
...