[{"date_created":"2020-12-20T23:01:19Z","oa_version":"None","_id":"8957","pmid":1,"publication":"Developmental Cell","date_published":"2020-12-21T00:00:00Z","publication_identifier":{"eissn":["1878-1551"],"issn":["1534-5807"]},"external_id":{"isi":["000600665700008"],"pmid":["33207225"]},"author":[{"id":"33280250-F248-11E8-B48F-1D18A9856A87","first_name":"Benoit G","last_name":"Godard","full_name":"Godard, Benoit G"},{"first_name":"Rémi","last_name":"Dumollard","full_name":"Dumollard, Rémi"},{"full_name":"Munro, Edwin","last_name":"Munro","first_name":"Edwin"},{"first_name":"Janet","last_name":"Chenevert","full_name":"Chenevert, Janet"},{"full_name":"Hebras, Céline","last_name":"Hebras","first_name":"Céline"},{"first_name":"Alex","last_name":"Mcdougall","full_name":"Mcdougall, Alex"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J","last_name":"Heisenberg","first_name":"Carl-Philipp J"}],"title":"Apical relaxation during mitotic rounding promotes tension-oriented cell division","acknowledgement":"We thank members of the Heisenberg and McDougall groups for technical advice and discussion, Hitoyoshi Yasuo for sharing lab equipment, Lucas Leclère and Hitoyoshi Yasuo for their comments on a preliminary version of the manuscript, and Philippe Dru for the Rose plots. We are grateful to the Bioimaging and Nanofabrication facilities of IST Austria and the Imaging Platform (PIM) and animal facility (CRB) of Institut de la Mer de Villefranche (IMEV), which is supported by EMBRC-France, whose French state funds are managed by the ANR within the Investments of the Future program under reference ANR-10-INBS-0, for continuous support. This work was supported by a grant from the French Government funding agency Agence National de la Recherche (ANR “MorCell”: ANR-17-CE 13-002 8).","article_type":"original","department":[{"_id":"CaHe"}],"day":"21","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_updated":"2025-07-10T12:01:28Z","publication_status":"published","corr_author":"1","publisher":"Elsevier","type":"journal_article","intvolume":"        55","scopus_import":"1","doi":"10.1016/j.devcel.2020.10.016","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/relaxing-cell-divisions/","description":"News on IST Homepage"}]},"citation":{"apa":"Godard, B. G., Dumollard, R., Munro, E., Chenevert, J., Hebras, C., Mcdougall, A., &#38; Heisenberg, C.-P. J. (2020). Apical relaxation during mitotic rounding promotes tension-oriented cell division. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2020.10.016\">https://doi.org/10.1016/j.devcel.2020.10.016</a>","mla":"Godard, Benoit G., et al. “Apical Relaxation during Mitotic Rounding Promotes Tension-Oriented Cell Division.” <i>Developmental Cell</i>, vol. 55, no. 6, Elsevier, 2020, pp. 695–706, doi:<a href=\"https://doi.org/10.1016/j.devcel.2020.10.016\">10.1016/j.devcel.2020.10.016</a>.","ieee":"B. G. Godard <i>et al.</i>, “Apical relaxation during mitotic rounding promotes tension-oriented cell division,” <i>Developmental Cell</i>, vol. 55, no. 6. Elsevier, pp. 695–706, 2020.","chicago":"Godard, Benoit G, Rémi Dumollard, Edwin Munro, Janet Chenevert, Céline Hebras, Alex Mcdougall, and Carl-Philipp J Heisenberg. “Apical Relaxation during Mitotic Rounding Promotes Tension-Oriented Cell Division.” <i>Developmental Cell</i>. Elsevier, 2020. <a href=\"https://doi.org/10.1016/j.devcel.2020.10.016\">https://doi.org/10.1016/j.devcel.2020.10.016</a>.","ista":"Godard BG, Dumollard R, Munro E, Chenevert J, Hebras C, Mcdougall A, Heisenberg C-PJ. 2020. Apical relaxation during mitotic rounding promotes tension-oriented cell division. Developmental Cell. 55(6), 695–706.","ama":"Godard BG, Dumollard R, Munro E, et al. Apical relaxation during mitotic rounding promotes tension-oriented cell division. <i>Developmental Cell</i>. 2020;55(6):695-706. doi:<a href=\"https://doi.org/10.1016/j.devcel.2020.10.016\">10.1016/j.devcel.2020.10.016</a>","short":"B.G. Godard, R. Dumollard, E. Munro, J. Chenevert, C. Hebras, A. Mcdougall, C.-P.J. Heisenberg, Developmental Cell 55 (2020) 695–706."},"abstract":[{"text":"Global tissue tension anisotropy has been shown to trigger stereotypical cell division orientation by elongating mitotic cells along the main tension axis. Yet, how tissue tension elongates mitotic cells despite those cells undergoing mitotic rounding (MR) by globally upregulating cortical actomyosin tension remains unclear. We addressed this question by taking advantage of ascidian embryos, consisting of a small number of interphasic and mitotic blastomeres and displaying an invariant division pattern. We found that blastomeres undergo MR by locally relaxing cortical tension at their apex, thereby allowing extrinsic pulling forces from neighboring interphasic blastomeres to polarize their shape and thus division orientation. Consistently, interfering with extrinsic forces by reducing the contractility of interphasic blastomeres or disrupting the establishment of asynchronous mitotic domains leads to aberrant mitotic cell division orientations. Thus, apical relaxation during MR constitutes a key mechanism by which tissue tension anisotropy controls stereotypical cell division orientation.","lang":"eng"}],"article_processing_charge":"No","isi":1,"month":"12","issue":"6","page":"695-706","acknowledged_ssus":[{"_id":"Bio"},{"_id":"NanoFab"}],"quality_controlled":"1","year":"2020","language":[{"iso":"eng"}],"volume":55},{"publication":"Developmental Cell","publist_id":"6320","file":[{"relation":"main_file","date_created":"2018-12-12T10:10:57Z","file_size":6866187,"creator":"system","file_name":"IST-2017-869-v1+1_1-s2.0-S1534580717300370-main.pdf","file_id":"4849","date_updated":"2018-12-12T10:10:57Z","content_type":"application/pdf","access_level":"open_access"}],"oa_version":"Published Version","date_created":"2018-12-11T11:49:58Z","project":[{"name":"Developing High-Throughput Bioassays for Human Cancers in Zebrafish","call_identifier":"FP7","grant_number":"201439","_id":"2524F500-B435-11E9-9278-68D0E5697425"}],"_id":"1067","external_id":{"isi":["000395368300007"]},"oa":1,"date_published":"2017-02-27T00:00:00Z","publication_identifier":{"issn":["1534-5807"]},"day":"27","department":[{"_id":"CaHe"}],"ec_funded":1,"title":"The physical basis of coordinated tissue spreading in zebrafish gastrulation","author":[{"id":"4C6E54C6-F248-11E8-B48F-1D18A9856A87","last_name":"Morita","first_name":"Hitoshi","full_name":"Morita, Hitoshi"},{"full_name":"Grigolon, Silvia","first_name":"Silvia","last_name":"Grigolon"},{"last_name":"Bock","first_name":"Martin","full_name":"Bock, Martin"},{"id":"2B819732-F248-11E8-B48F-1D18A9856A87","first_name":"Gabriel","last_name":"Krens","orcid":"0000-0003-4761-5996","full_name":"Krens, Gabriel"},{"full_name":"Salbreux, Guillaume","last_name":"Salbreux","first_name":"Guillaume"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","first_name":"Carl-Philipp J","last_name":"Heisenberg"}],"status":"public","tmp":{"short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)"},"date_updated":"2025-07-10T11:49:55Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","has_accepted_license":"1","intvolume":"        40","pubrep_id":"869","publication_status":"published","publisher":"Cell Press","corr_author":"1","type":"journal_article","citation":{"ama":"Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. The physical basis of coordinated tissue spreading in zebrafish gastrulation. <i>Developmental Cell</i>. 2017;40(4):354-366. doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.01.010\">10.1016/j.devcel.2017.01.010</a>","short":"H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, C.-P.J. Heisenberg, Developmental Cell 40 (2017) 354–366.","ieee":"H. Morita, S. Grigolon, M. Bock, G. Krens, G. Salbreux, and C.-P. J. Heisenberg, “The physical basis of coordinated tissue spreading in zebrafish gastrulation,” <i>Developmental Cell</i>, vol. 40, no. 4. Cell Press, pp. 354–366, 2017.","ista":"Morita H, Grigolon S, Bock M, Krens G, Salbreux G, Heisenberg C-PJ. 2017. The physical basis of coordinated tissue spreading in zebrafish gastrulation. Developmental Cell. 40(4), 354–366.","chicago":"Morita, Hitoshi, Silvia Grigolon, Martin Bock, Gabriel Krens, Guillaume Salbreux, and Carl-Philipp J Heisenberg. “The Physical Basis of Coordinated Tissue Spreading in Zebrafish Gastrulation.” <i>Developmental Cell</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.devcel.2017.01.010\">https://doi.org/10.1016/j.devcel.2017.01.010</a>.","mla":"Morita, Hitoshi, et al. “The Physical Basis of Coordinated Tissue Spreading in Zebrafish Gastrulation.” <i>Developmental Cell</i>, vol. 40, no. 4, Cell Press, 2017, pp. 354–66, doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.01.010\">10.1016/j.devcel.2017.01.010</a>.","apa":"Morita, H., Grigolon, S., Bock, M., Krens, G., Salbreux, G., &#38; Heisenberg, C.-P. J. (2017). The physical basis of coordinated tissue spreading in zebrafish gastrulation. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2017.01.010\">https://doi.org/10.1016/j.devcel.2017.01.010</a>"},"abstract":[{"text":"Embryo morphogenesis relies on highly coordinated movements of different tissues. However, remarkably little is known about how tissues coordinate their movements to shape the embryo. In zebrafish embryogenesis, coordinated tissue movements first become apparent during “doming,” when the blastoderm begins to spread over the yolk sac, a process involving coordinated epithelial surface cell layer expansion and mesenchymal deep cell intercalations. Here, we find that active surface cell expansion represents the key process coordinating tissue movements during doming. By using a combination of theory and experiments, we show that epithelial surface cells not only trigger blastoderm expansion by reducing tissue surface tension, but also drive blastoderm thinning by inducing tissue contraction through radial deep cell intercalations. Thus, coordinated tissue expansion and thinning during doming relies on surface cells simultaneously controlling tissue surface tension and radial tissue contraction.","lang":"eng"}],"scopus_import":"1","doi":"10.1016/j.devcel.2017.01.010","month":"02","issue":"4","page":"354 - 366","file_date_updated":"2018-12-12T10:10:57Z","article_processing_charge":"No","isi":1,"license":"https://creativecommons.org/licenses/by/4.0/","language":[{"iso":"eng"}],"volume":40,"quality_controlled":"1","acknowledged_ssus":[{"_id":"PreCl"}],"ddc":["572","597"],"year":"2017"},{"year":"2017","quality_controlled":"1","volume":42,"language":[{"iso":"eng"}],"isi":1,"article_processing_charge":"No","issue":"6","page":"559 - 560","month":"01","doi":"10.1016/j.devcel.2017.09.008","scopus_import":"1","abstract":[{"lang":"eng","text":"The cellular mechanisms allowing tissues to efficiently regenerate are not fully understood. In this issue of Developmental Cell, Cao et al. (2017)) discover that during zebrafish heart regeneration, epicardial cells at the leading edge of regenerating tissue undergo endoreplication, possibly due to increased tissue tension, thereby boosting their regenerative capacity."}],"citation":{"ama":"Spiro ZP, Heisenberg C-PJ. Regeneration tensed up polyploidy takes the lead. <i>Developmental Cell</i>. 2017;42(6):559-560. doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.09.008\">10.1016/j.devcel.2017.09.008</a>","short":"Z.P. Spiro, C.-P.J. Heisenberg, Developmental Cell 42 (2017) 559–560.","chicago":"Spiro, Zoltan P, and Carl-Philipp J Heisenberg. “Regeneration Tensed up Polyploidy Takes the Lead.” <i>Developmental Cell</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.devcel.2017.09.008\">https://doi.org/10.1016/j.devcel.2017.09.008</a>.","ista":"Spiro ZP, Heisenberg C-PJ. 2017. Regeneration tensed up polyploidy takes the lead. Developmental Cell. 42(6), 559–560.","ieee":"Z. P. Spiro and C.-P. J. Heisenberg, “Regeneration tensed up polyploidy takes the lead,” <i>Developmental Cell</i>, vol. 42, no. 6. Cell Press, pp. 559–560, 2017.","apa":"Spiro, Z. P., &#38; Heisenberg, C.-P. J. (2017). Regeneration tensed up polyploidy takes the lead. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2017.09.008\">https://doi.org/10.1016/j.devcel.2017.09.008</a>","mla":"Spiro, Zoltan P., and Carl-Philipp J. Heisenberg. “Regeneration Tensed up Polyploidy Takes the Lead.” <i>Developmental Cell</i>, vol. 42, no. 6, Cell Press, 2017, pp. 559–60, doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.09.008\">10.1016/j.devcel.2017.09.008</a>."},"type":"journal_article","publisher":"Cell Press","corr_author":"1","publication_status":"published","intvolume":"        42","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2025-07-10T11:54:28Z","status":"public","author":[{"id":"426AD026-F248-11E8-B48F-1D18A9856A87","full_name":"Spiro, Zoltan P","last_name":"Spiro","first_name":"Zoltan P"},{"first_name":"Carl-Philipp J","last_name":"Heisenberg","full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"title":"Regeneration tensed up polyploidy takes the lead","department":[{"_id":"CaHe"}],"day":"01","publication_identifier":{"issn":["1534-5807"]},"date_published":"2017-01-01T00:00:00Z","external_id":{"isi":["000411582800003"]},"_id":"729","date_created":"2018-12-11T11:48:11Z","oa_version":"None","publist_id":"6948","publication":"Developmental Cell"},{"publication_status":"published","type":"journal_article","publisher":"Cell Press","corr_author":"1","intvolume":"        43","scopus_import":"1","doi":"10.1016/j.devcel.2017.09.014","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"961"},{"relation":"dissertation_contains","id":"8350","status":"public"}]},"citation":{"apa":"Barone, V., Lang, M., Krens, G., Pradhan, S., Shamipour, S., Sako, K., … Heisenberg, C.-P. J. (2017). An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">https://doi.org/10.1016/j.devcel.2017.09.014</a>","mla":"Barone, Vanessa, et al. “An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate.” <i>Developmental Cell</i>, vol. 43, no. 2, Cell Press, 2017, pp. 198–211, doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">10.1016/j.devcel.2017.09.014</a>.","ama":"Barone V, Lang M, Krens G, et al. An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate. <i>Developmental Cell</i>. 2017;43(2):198-211. doi:<a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">10.1016/j.devcel.2017.09.014</a>","short":"V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora, C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.","chicago":"Barone, Vanessa, Moritz Lang, Gabriel Krens, Saurabh Pradhan, Shayan Shamipour, Keisuke Sako, Mateusz K Sikora, Calin C Guet, and Carl-Philipp J Heisenberg. “An Effective Feedback Loop between Cell-Cell Contact Duration and Morphogen Signaling Determines Cell Fate.” <i>Developmental Cell</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.devcel.2017.09.014\">https://doi.org/10.1016/j.devcel.2017.09.014</a>.","ista":"Barone V, Lang M, Krens G, Pradhan S, Shamipour S, Sako K, Sikora MK, Guet CC, Heisenberg C-PJ. 2017. An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate. Developmental Cell. 43(2), 198–211.","ieee":"V. Barone <i>et al.</i>, “An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate,” <i>Developmental Cell</i>, vol. 43, no. 2. Cell Press, pp. 198–211, 2017."},"abstract":[{"text":"Cell-cell contact formation constitutes an essential step in evolution, leading to the differentiation of specialized cell types. However, remarkably little is known about whether and how the interplay between contact formation and fate specification affects development. Here, we identify a positive feedback loop between cell-cell contact duration, morphogen signaling, and mesendoderm cell-fate specification during zebrafish gastrulation. We show that long-lasting cell-cell contacts enhance the competence of prechordal plate (ppl) progenitor cells to respond to Nodal signaling, required for ppl cell-fate specification. We further show that Nodal signaling promotes ppl cell-cell contact duration, generating a positive feedback loop between ppl cell-cell contact duration and cell-fate specification. Finally, by combining mathematical modeling and experimentation, we show that this feedback determines whether anterior axial mesendoderm cells become ppl or, instead, turn into endoderm. Thus, the interdependent activities of cell-cell signaling and contact formation control fate diversification within the developing embryo.","lang":"eng"}],"article_processing_charge":"No","isi":1,"month":"10","page":"198 - 211","issue":"2","quality_controlled":"1","year":"2017","language":[{"iso":"eng"}],"volume":43,"date_created":"2018-12-11T11:48:13Z","oa_version":"None","_id":"735","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme","call_identifier":"FP7"},{"call_identifier":"FWF","name":"Cell segregation in gastrulation: the role of cell fate specification","grant_number":"I2058","_id":"252DD2A6-B435-11E9-9278-68D0E5697425"}],"publication":"Developmental Cell","publist_id":"6934","date_published":"2017-10-23T00:00:00Z","publication_identifier":{"issn":["1534-5807"]},"external_id":{"isi":["000413443700011"]},"author":[{"id":"419EECCC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-2676-3367","full_name":"Barone, Vanessa","last_name":"Barone","first_name":"Vanessa"},{"id":"29E0800A-F248-11E8-B48F-1D18A9856A87","last_name":"Lang","first_name":"Moritz","full_name":"Lang, Moritz"},{"orcid":"0000-0003-4761-5996","full_name":"Krens, Gabriel","last_name":"Krens","first_name":"Gabriel","id":"2B819732-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Pradhan, Saurabh","last_name":"Pradhan","first_name":"Saurabh"},{"id":"40B34FE2-F248-11E8-B48F-1D18A9856A87","full_name":"Shamipour, Shayan","last_name":"Shamipour","first_name":"Shayan"},{"id":"3BED66BE-F248-11E8-B48F-1D18A9856A87","last_name":"Sako","first_name":"Keisuke","orcid":"0000-0002-6453-8075","full_name":"Sako, Keisuke"},{"id":"2F74BCDE-F248-11E8-B48F-1D18A9856A87","full_name":"Sikora, Mateusz K","last_name":"Sikora","first_name":"Mateusz K"},{"id":"47F8433E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","last_name":"Guet","first_name":"Calin C"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","last_name":"Heisenberg","first_name":"Carl-Philipp J","id":"39427864-F248-11E8-B48F-1D18A9856A87"}],"title":"An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate","ec_funded":1,"department":[{"_id":"CaHe"},{"_id":"CaGu"},{"_id":"GaTk"}],"day":"23","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_updated":"2026-08-12T22:30:18Z"},{"publist_id":"6510","extern":"1","publication":"Developmental Cell","_id":"932","pmid":1,"date_created":"2018-12-11T11:49:16Z","oa_version":"Published Version","oa":1,"external_id":{"pmid":["26766441"]},"OA_type":"free access","publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"date_published":"2016-01-12T00:00:00Z","day":"12","acknowledgement":"We thank J. Bear, B. Goldstein, A. Ewald, and D. Soroldoni for critical reading. This work was funded by an EMBO Long Term Fellowship to J.S., a Research Fellowship from Trinity College, Cambridge and a Bettencourt-Schueller Foundation Young Researcher Prize to E.H., a Cancer Institute NSW Early Career Researcher fellowship (13/ECF/1–25) and a Cancer Australia/Cure Cancer Australia Foundation project grant (1070498) to M.B., and grants from the NHLBI (HL117164) and NIGMS (GM074104) to J.B.W. J.B.W. was an early career scientist of the Howard Hughes Medical Institute. This work was initiated at the New Quantitative Approaches to Morphogenesis Workshop at UCSB, which is funded in part by the National Science Foundation (PHY11-25915) and the NIGMS (GM067110-05).","OA_place":"publisher","article_type":"original","title":"Emergence of an Apical Epithelial Cell Surface In Vivo","main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2015.12.013","open_access":"1"}],"author":[{"first_name":"Jakub","last_name":"Sedzinski","full_name":"Sedzinski, Jakub"},{"id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B","full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561"},{"full_name":"Tu, Fan","last_name":"Tu","first_name":"Fan"},{"last_name":"Biro","first_name":"Maté","full_name":"Biro, Maté"},{"last_name":"Wallingford","first_name":"John","full_name":"Wallingford, John"}],"date_updated":"2026-05-20T09:14:43Z","status":"public","user_id":"ba8df636-2132-11f1-aed0-ed93e2281fdd","intvolume":"        36","publisher":"Elsevier","type":"journal_article","publication_status":"published","abstract":[{"text":"Epithelial sheets are crucial components of all metazoan animals, enclosing organs and protecting the animal from its environment. Epithelial homeostasis poses unique challenges, as addition of new cells and loss of old cells must be achieved without disrupting the fluid-tight barrier and apicobasal polarity of the epithelium. Several studies have identified cell biological mechanisms underlying extrusion of cells from epithelia, but far less is known of the converse mechanism by which new cells are added. Here, we combine molecular, pharmacological, and laser-dissection experiments with theoretical modeling to characterize forces driving emergence of an apical surface as single nascent cells are added to a vertebrate epithelium in vivo. We find that this process involves the interplay between cell-autonomous actin-generated pushing forces in the emerging cell and mechanical properties of neighboring cells. Our findings define the forces driving this cell behavior, contributing to a more comprehensive understanding of epithelial homeostasis.","lang":"eng"}],"citation":{"mla":"Sedzinski, Jakub, et al. “Emergence of an Apical Epithelial Cell Surface In Vivo.” <i>Developmental Cell</i>, vol. 36, no. 1, Elsevier, 2016, pp. 24–35, doi:<a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">10.1016/j.devcel.2015.12.013</a>.","apa":"Sedzinski, J., Hannezo, E. B., Tu, F., Biro, M., &#38; Wallingford, J. (2016). Emergence of an Apical Epithelial Cell Surface In Vivo. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">https://doi.org/10.1016/j.devcel.2015.12.013</a>","ieee":"J. Sedzinski, E. B. Hannezo, F. Tu, M. Biro, and J. Wallingford, “Emergence of an Apical Epithelial Cell Surface In Vivo,” <i>Developmental Cell</i>, vol. 36, no. 1. Elsevier, pp. 24–35, 2016.","chicago":"Sedzinski, Jakub, Edouard B Hannezo, Fan Tu, Maté Biro, and John Wallingford. “Emergence of an Apical Epithelial Cell Surface In Vivo.” <i>Developmental Cell</i>. Elsevier, 2016. <a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">https://doi.org/10.1016/j.devcel.2015.12.013</a>.","ista":"Sedzinski J, Hannezo EB, Tu F, Biro M, Wallingford J. 2016. Emergence of an Apical Epithelial Cell Surface In Vivo. Developmental Cell. 36(1), 24–35.","short":"J. Sedzinski, E.B. Hannezo, F. Tu, M. Biro, J. Wallingford, Developmental Cell 36 (2016) 24–35.","ama":"Sedzinski J, Hannezo EB, Tu F, Biro M, Wallingford J. Emergence of an Apical Epithelial Cell Surface In Vivo. <i>Developmental Cell</i>. 2016;36(1):24-35. doi:<a href=\"https://doi.org/10.1016/j.devcel.2015.12.013\">10.1016/j.devcel.2015.12.013</a>"},"doi":"10.1016/j.devcel.2015.12.013","scopus_import":"1","issue":"1","page":"24 - 35","month":"01","article_processing_charge":"No","volume":36,"language":[{"iso":"eng"}],"year":"2016","quality_controlled":"1"},{"language":[{"iso":"eng"}],"volume":29,"quality_controlled":"1","year":"2014","month":"06","page":"P729-739","issue":"6","article_processing_charge":"No","citation":{"ista":"Hofbauer HF, Schopf FH, Schleifer H, Knittelfelder OL, Pieber B, Rechberger GN, Wolinski H, Gaspar ML, Kappe CO, Stadlmann J, Mechtler K, Zenz A, Lohner K, Tehlivets O, Henry SA, Kohlwein SD. 2014. Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. Developmental Cell. 29(6), P729-739.","chicago":"Hofbauer, Harald F., Florian H. Schopf, Hannes Schleifer, Oskar L. Knittelfelder, Bartholomäus Pieber, Gerald N. Rechberger, Heimo Wolinski, et al. “Regulation of Gene Expression through a Transcriptional Repressor That Senses Acyl-Chain Length in Membrane Phospholipids.” <i>Developmental Cell</i>. Elsevier, 2014. <a href=\"https://doi.org/10.1016/j.devcel.2014.04.025\">https://doi.org/10.1016/j.devcel.2014.04.025</a>.","ieee":"H. F. Hofbauer <i>et al.</i>, “Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids,” <i>Developmental Cell</i>, vol. 29, no. 6. Elsevier, pp. P729-739, 2014.","ama":"Hofbauer HF, Schopf FH, Schleifer H, et al. Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. <i>Developmental Cell</i>. 2014;29(6):P729-739. doi:<a href=\"https://doi.org/10.1016/j.devcel.2014.04.025\">10.1016/j.devcel.2014.04.025</a>","short":"H.F. Hofbauer, F.H. Schopf, H. Schleifer, O.L. Knittelfelder, B. Pieber, G.N. Rechberger, H. Wolinski, M.L. Gaspar, C.O. Kappe, J. Stadlmann, K. Mechtler, A. Zenz, K. Lohner, O. Tehlivets, S.A. Henry, S.D. Kohlwein, Developmental Cell 29 (2014) P729-739.","mla":"Hofbauer, Harald F., et al. “Regulation of Gene Expression through a Transcriptional Repressor That Senses Acyl-Chain Length in Membrane Phospholipids.” <i>Developmental Cell</i>, vol. 29, no. 6, Elsevier, 2014, pp. P729-739, doi:<a href=\"https://doi.org/10.1016/j.devcel.2014.04.025\">10.1016/j.devcel.2014.04.025</a>.","apa":"Hofbauer, H. F., Schopf, F. H., Schleifer, H., Knittelfelder, O. L., Pieber, B., Rechberger, G. N., … Kohlwein, S. D. (2014). Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2014.04.025\">https://doi.org/10.1016/j.devcel.2014.04.025</a>"},"abstract":[{"lang":"eng","text":"Membrane phospholipids typically contain fatty acids (FAs) of 16 and 18 carbon atoms. This particular chain length is evolutionarily highly conserved and presumably provides maximum stability and dynamic properties to biological membranes in response to nutritional or environmental cues. Here, we show that the relative proportion of C16 versus C18 FAs is regulated by the activity of acetyl-CoA carboxylase (Acc1), the first and rate-limiting enzyme of FA de novo synthesis. Acc1 activity is attenuated by AMPK/Snf1-dependent phosphorylation, which is required to maintain an appropriate acyl-chain length distribution. Moreover, we find that the transcriptional repressor Opi1 preferentially binds to C16 over C18 phosphatidic acid (PA) species: thus, C16-chain containing PA sequesters Opi1 more effectively to the ER, enabling AMPK/Snf1 control of PA acyl-chain length to determine the degree of derepression of Opi1 target genes. These findings reveal an unexpected regulatory link between the major energy-sensing kinase, membrane lipid composition, and transcription."}],"scopus_import":"1","doi":"10.1016/j.devcel.2014.04.025","intvolume":"        29","publication_status":"published","publisher":"Elsevier","type":"journal_article","status":"public","date_updated":"2023-02-21T10:09:45Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","day":"23","author":[{"full_name":"Hofbauer, Harald F.","first_name":"Harald F.","last_name":"Hofbauer"},{"full_name":"Schopf, Florian H.","first_name":"Florian H.","last_name":"Schopf"},{"full_name":"Schleifer, Hannes","last_name":"Schleifer","first_name":"Hannes"},{"full_name":"Knittelfelder, Oskar L.","last_name":"Knittelfelder","first_name":"Oskar L."},{"id":"93e5e5b2-0da6-11ed-8a41-af589a024726","last_name":"Pieber","first_name":"Bartholomäus","full_name":"Pieber, Bartholomäus","orcid":"0000-0001-8689-388X"},{"full_name":"Rechberger, Gerald N.","first_name":"Gerald N.","last_name":"Rechberger"},{"full_name":"Wolinski, Heimo","first_name":"Heimo","last_name":"Wolinski"},{"last_name":"Gaspar","first_name":"Maria L.","full_name":"Gaspar, Maria L."},{"full_name":"Kappe, C. Oliver","first_name":"C. Oliver","last_name":"Kappe"},{"first_name":"Johannes","last_name":"Stadlmann","full_name":"Stadlmann, Johannes"},{"full_name":"Mechtler, Karl","last_name":"Mechtler","first_name":"Karl"},{"first_name":"Alexandra","last_name":"Zenz","full_name":"Zenz, Alexandra"},{"full_name":"Lohner, Karl","last_name":"Lohner","first_name":"Karl"},{"full_name":"Tehlivets, Oksana","last_name":"Tehlivets","first_name":"Oksana"},{"last_name":"Henry","first_name":"Susan A.","full_name":"Henry, Susan A."},{"last_name":"Kohlwein","first_name":"Sepp D.","full_name":"Kohlwein, Sepp D."}],"title":"Regulation of gene expression through a transcriptional repressor that senses acyl-chain length in membrane phospholipids","main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2014.04.025","open_access":"1"}],"external_id":{"pmid":["24960695"]},"oa":1,"date_published":"2014-06-23T00:00:00Z","publication_identifier":{"eissn":["1878-1551"],"issn":["1534-5807"]},"publication":"Developmental Cell","extern":"1","oa_version":"Published Version","date_created":"2022-08-25T08:42:42Z","pmid":1,"_id":"11968"},{"oa":1,"external_id":{"pmid":["23410937"]},"publication_identifier":{"issn":["1534-5807"],"eissn":["1878-1551"]},"date_published":"2013-02-11T00:00:00Z","extern":"1","publication":"Developmental Cell","_id":"9520","pmid":1,"date_created":"2021-06-08T06:14:50Z","oa_version":"Published Version","date_updated":"2023-05-08T11:00:59Z","status":"public","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","day":"11","department":[{"_id":"DaZi"},{"_id":"XiFe"}],"article_type":"review","main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2013.01.014","open_access":"1"}],"author":[{"id":"e0164712-22ee-11ed-b12a-d80fcdf35958","last_name":"Feng","first_name":"Xiaoqi","orcid":"0000-0002-4008-1234","full_name":"Feng, Xiaoqi"},{"last_name":"Zilberman","first_name":"Daniel","full_name":"Zilberman, Daniel","orcid":"0000-0002-0123-8649","id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1"},{"first_name":"Hugh","last_name":"Dickinson","full_name":"Dickinson, Hugh"}],"title":"A conversation across generations: Soma-germ cell crosstalk in plants","abstract":[{"text":"Plants undergo alternation of generation in which reproductive cells develop in the plant body (\"sporophytic generation\") and then differentiate into a multicellular gamete-forming \"gametophytic generation.\" Different populations of helper cells assist in this transgenerational journey, with somatic tissues supporting early development and single nurse cells supporting gametogenesis. New data reveal a two-way relationship between early reproductive cells and their helpers involving complex epigenetic and signaling networks determining cell number and fate. Later, the egg cell plays a central role in specifying accessory cells, whereas in both gametophytes, companion cells contribute non-cell-autonomously to the epigenetic landscape of the gamete genomes.","lang":"eng"}],"citation":{"apa":"Feng, X., Zilberman, D., &#38; Dickinson, H. (2013). A conversation across generations: Soma-germ cell crosstalk in plants. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2013.01.014\">https://doi.org/10.1016/j.devcel.2013.01.014</a>","mla":"Feng, Xiaoqi, et al. “A Conversation across Generations: Soma-Germ Cell Crosstalk in Plants.” <i>Developmental Cell</i>, vol. 24, no. 3, Elsevier, 2013, pp. 215–25, doi:<a href=\"https://doi.org/10.1016/j.devcel.2013.01.014\">10.1016/j.devcel.2013.01.014</a>.","ieee":"X. Feng, D. Zilberman, and H. Dickinson, “A conversation across generations: Soma-germ cell crosstalk in plants,” <i>Developmental Cell</i>, vol. 24, no. 3. Elsevier, pp. 215–225, 2013.","ista":"Feng X, Zilberman D, Dickinson H. 2013. A conversation across generations: Soma-germ cell crosstalk in plants. Developmental Cell. 24(3), 215–225.","chicago":"Feng, Xiaoqi, Daniel Zilberman, and Hugh Dickinson. “A Conversation across Generations: Soma-Germ Cell Crosstalk in Plants.” <i>Developmental Cell</i>. Elsevier, 2013. <a href=\"https://doi.org/10.1016/j.devcel.2013.01.014\">https://doi.org/10.1016/j.devcel.2013.01.014</a>.","ama":"Feng X, Zilberman D, Dickinson H. A conversation across generations: Soma-germ cell crosstalk in plants. <i>Developmental Cell</i>. 2013;24(3):215-225. doi:<a href=\"https://doi.org/10.1016/j.devcel.2013.01.014\">10.1016/j.devcel.2013.01.014</a>","short":"X. Feng, D. Zilberman, H. Dickinson, Developmental Cell 24 (2013) 215–225."},"doi":"10.1016/j.devcel.2013.01.014","scopus_import":"1","intvolume":"        24","publisher":"Elsevier","type":"journal_article","publication_status":"published","volume":24,"language":[{"iso":"eng"}],"year":"2013","quality_controlled":"1","issue":"3","page":"215-225","month":"02","article_processing_charge":"No"},{"year":"2012","quality_controlled":"1","volume":22,"language":[{"iso":"eng"}],"article_processing_charge":"No","issue":"2","page":"446-458","month":"01","doi":"10.1016/j.devcel.2011.11.021","scopus_import":"1","abstract":[{"text":"Nuclear pore complexes (NPCs) are built from ∼30 different proteins called nucleoporins or Nups. Previous studies have shown that several Nups exhibit cell-type-specific expression and that mutations in NPC components result in tissue-specific diseases. Here we show that a specific change in NPC composition is required for both myogenic and neuronal differentiation. The transmembrane nucleoporin Nup210 is absent in proliferating myoblasts and embryonic stem cells (ESCs) but becomes expressed and incorporated into NPCs during cell differentiation. Preventing Nup210 production by RNAi blocks myogenesis and the differentiation of ESCs into neuroprogenitors. We found that the addition of Nup210 to NPCs does not affect nuclear transport but is required for the induction of genes that are essential for cell differentiation. Our results identify a single change in NPC composition as an essential step in cell differentiation and establish a role for Nup210 in gene expression regulation and cell fate determination.","lang":"eng"}],"citation":{"mla":"D’Angelo, Maximiliano A., et al. “A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation.” <i>Developmental Cell</i>, vol. 22, no. 2, Elsevier, 2012, pp. 446–58, doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">10.1016/j.devcel.2011.11.021</a>.","apa":"D’Angelo, M. A., Gomez-Cavazos, J. S., Mei, A., Lackner, D. H., &#38; Hetzer, M. (2012). A change in nuclear pore complex composition regulates cell differentiation. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">https://doi.org/10.1016/j.devcel.2011.11.021</a>","short":"M.A. D’Angelo, J.S. Gomez-Cavazos, A. Mei, D.H. Lackner, M. Hetzer, Developmental Cell 22 (2012) 446–458.","ama":"D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. A change in nuclear pore complex composition regulates cell differentiation. <i>Developmental Cell</i>. 2012;22(2):446-458. doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">10.1016/j.devcel.2011.11.021</a>","ieee":"M. A. D’Angelo, J. S. Gomez-Cavazos, A. Mei, D. H. Lackner, and M. Hetzer, “A change in nuclear pore complex composition regulates cell differentiation,” <i>Developmental Cell</i>, vol. 22, no. 2. Elsevier, pp. 446–458, 2012.","ista":"D’Angelo MA, Gomez-Cavazos JS, Mei A, Lackner DH, Hetzer M. 2012. A change in nuclear pore complex composition regulates cell differentiation. Developmental Cell. 22(2), 446–458.","chicago":"D’Angelo, Maximiliano A., J. Sebastian Gomez-Cavazos, Arianna Mei, Daniel H. Lackner, and Martin Hetzer. “A Change in Nuclear Pore Complex Composition Regulates Cell Differentiation.” <i>Developmental Cell</i>. Elsevier, 2012. <a href=\"https://doi.org/10.1016/j.devcel.2011.11.021\">https://doi.org/10.1016/j.devcel.2011.11.021</a>."},"type":"journal_article","publisher":"Elsevier","publication_status":"published","intvolume":"        22","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","keyword":["Developmental Biology","Cell Biology","General Biochemistry","Genetics and Molecular Biology","Molecular Biology"],"date_updated":"2024-10-14T11:26:00Z","status":"public","title":"A change in nuclear pore complex composition regulates cell differentiation","main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2011.11.021","open_access":"1"}],"author":[{"full_name":"D'Angelo, Maximiliano A.","last_name":"D'Angelo","first_name":"Maximiliano A."},{"full_name":"Gomez-Cavazos, J. Sebastian","first_name":"J. Sebastian","last_name":"Gomez-Cavazos"},{"full_name":"Mei, Arianna","last_name":"Mei","first_name":"Arianna"},{"full_name":"Lackner, Daniel H.","first_name":"Daniel H.","last_name":"Lackner"},{"last_name":"HETZER","first_name":"Martin W","orcid":"0000-0002-2111-992X","full_name":"HETZER, Martin W","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"}],"day":"19","article_type":"original","publication_identifier":{"issn":["1534-5807"]},"date_published":"2012-01-19T00:00:00Z","external_id":{"pmid":["22264802"]},"oa":1,"pmid":1,"_id":"11093","oa_version":"Published Version","date_created":"2022-04-07T07:52:10Z","publication":"Developmental Cell","extern":"1"},{"citation":{"ama":"Zilberman D. <i>Balancing Parental Contributions in Plant Embryonic Gene Activation</i>. Vol 20. Elsevier; 2011:735-736. doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.05.018\">10.1016/j.devcel.2011.05.018</a>","short":"D. Zilberman, Balancing Parental Contributions in Plant Embryonic Gene Activation, Elsevier, 2011.","ista":"Zilberman D. 2011. Balancing parental contributions in plant embryonic gene activation, Elsevier,p.","chicago":"Zilberman, Daniel. <i>Balancing Parental Contributions in Plant Embryonic Gene Activation</i>. <i>Developmental Cell</i>. Vol. 20. Elsevier, 2011. <a href=\"https://doi.org/10.1016/j.devcel.2011.05.018\">https://doi.org/10.1016/j.devcel.2011.05.018</a>.","ieee":"D. Zilberman, <i>Balancing parental contributions in plant embryonic gene activation</i>, vol. 20, no. 6. Elsevier, 2011, pp. 735–736.","mla":"Zilberman, Daniel. “Balancing Parental Contributions in Plant Embryonic Gene Activation.” <i>Developmental Cell</i>, vol. 20, no. 6, Elsevier, 2011, pp. 735–36, doi:<a href=\"https://doi.org/10.1016/j.devcel.2011.05.018\">10.1016/j.devcel.2011.05.018</a>.","apa":"Zilberman, D. (2011). <i>Balancing parental contributions in plant embryonic gene activation</i>. <i>Developmental Cell</i> (Vol. 20, pp. 735–736). Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2011.05.018\">https://doi.org/10.1016/j.devcel.2011.05.018</a>"},"abstract":[{"lang":"eng","text":"Little is known about chromatin remodeling events immediately after fertilization. A recent report by Autran et al. (2011) in Cell now shows that chromatin regulatory pathways that silence transposable elements are responsible for global delayed activation of gene expression in the early Arabidopsis embryo."}],"doi":"10.1016/j.devcel.2011.05.018","intvolume":"        20","publication_status":"published","publisher":"Elsevier","type":"other_academic_publication","language":[{"iso":"eng"}],"volume":20,"quality_controlled":"1","year":"2011","month":"06","page":"735-736","issue":"6","article_processing_charge":"No","external_id":{"pmid":["21664571"]},"oa":1,"date_published":"2011-06-14T00:00:00Z","publication_identifier":{"eissn":["1878-1551"],"issn":["1534-5807"]},"extern":"1","publication":"Developmental Cell","oa_version":"Published Version","date_created":"2021-06-08T06:23:39Z","pmid":1,"_id":"9522","status":"public","date_updated":"2021-12-14T08:34:37Z","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","day":"14","department":[{"_id":"DaZi"}],"title":"Balancing parental contributions in plant embryonic gene activation","author":[{"id":"6973db13-dd5f-11ea-814e-b3e5455e9ed1","first_name":"Daniel","last_name":"Zilberman","orcid":"0000-0002-0123-8649","full_name":"Zilberman, Daniel"}],"main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2011.05.018","open_access":"1"}]},{"year":"2009","quality_controlled":"1","volume":17,"language":[{"iso":"eng"}],"article_processing_charge":"No","issue":"5","page":"606-616","month":"11","doi":"10.1016/j.devcel.2009.10.007","scopus_import":"1","abstract":[{"text":"Over the last decade, the nuclear envelope (NE) has emerged as a key component in the organization and function of the nuclear genome. As many as 100 different proteins are thought to specifically localize to this double membrane that separates the cytoplasm and the nucleoplasm of eukaryotic cells. Selective portals through the NE are formed at sites where the inner and outer nuclear membranes are fused, and the coincident assembly of ∼30 proteins into nuclear pore complexes occurs. These nuclear pore complexes are essential for the control of nucleocytoplasmic exchange. Many of the NE and nuclear pore proteins are thought to play crucial roles in gene regulation and thus are increasingly linked to human diseases.","lang":"eng"}],"citation":{"apa":"Hetzer, M., &#38; Wente, S. R. (2009). Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. <i>Developmental Cell</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">https://doi.org/10.1016/j.devcel.2009.10.007</a>","mla":"Hetzer, Martin, and Susan R. Wente. “Border Control at the Nucleus: Biogenesis and Organization of the Nuclear Membrane and Pore Complexes.” <i>Developmental Cell</i>, vol. 17, no. 5, Elsevier, 2009, pp. 606–16, doi:<a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">10.1016/j.devcel.2009.10.007</a>.","ama":"Hetzer M, Wente SR. Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. <i>Developmental Cell</i>. 2009;17(5):606-616. doi:<a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">10.1016/j.devcel.2009.10.007</a>","short":"M. Hetzer, S.R. Wente, Developmental Cell 17 (2009) 606–616.","ieee":"M. Hetzer and S. R. Wente, “Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes,” <i>Developmental Cell</i>, vol. 17, no. 5. Elsevier, pp. 606–616, 2009.","ista":"Hetzer M, Wente SR. 2009. Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes. Developmental Cell. 17(5), 606–616.","chicago":"Hetzer, Martin, and Susan R. Wente. “Border Control at the Nucleus: Biogenesis and Organization of the Nuclear Membrane and Pore Complexes.” <i>Developmental Cell</i>. Elsevier, 2009. <a href=\"https://doi.org/10.1016/j.devcel.2009.10.007\">https://doi.org/10.1016/j.devcel.2009.10.007</a>."},"publisher":"Elsevier","type":"journal_article","publication_status":"published","intvolume":"        17","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","keyword":["Developmental Biology","Cell Biology","General Biochemistry","Genetics and Molecular Biology","Molecular Biology"],"date_updated":"2024-10-14T11:28:25Z","status":"public","author":[{"last_name":"HETZER","first_name":"Martin W","full_name":"HETZER, Martin W","orcid":"0000-0002-2111-992X","id":"86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed"},{"first_name":"Susan R.","last_name":"Wente","full_name":"Wente, Susan R."}],"title":"Border control at the nucleus: Biogenesis and organization of the nuclear membrane and pore complexes","main_file_link":[{"url":"https://doi.org/10.1016/j.devcel.2009.10.007","open_access":"1"}],"day":"17","article_type":"review","publication_identifier":{"issn":["1534-5807"]},"date_published":"2009-11-17T00:00:00Z","oa":1,"external_id":{"pmid":["19922866"]},"_id":"11103","pmid":1,"date_created":"2022-04-07T07:53:45Z","oa_version":"Published Version","extern":"1","publication":"Developmental Cell"},{"year":"2003","quality_controlled":"1","volume":5,"language":[{"iso":"eng"}],"article_processing_charge":"No","issue":"2","page":"190 - 191","month":"08","doi":"10.1016/S1534-5807(03)00235-1","scopus_import":"1","abstract":[{"text":"Recent studies show that signaling through integrin receptors is required for normal cell movements during Xenopus gastrulation. Integrins function in this process by modulating the activity of cadherin adhesion molecules within tissues undergoing convergence and extension movements.","lang":"eng"}],"citation":{"mla":"Montero, Juan, and Carl-Philipp J. Heisenberg. “Adhesive Crosstalk in Gastrulation.” <i>Developmental Cell</i>, vol. 5, no. 2, Cell Press, 2003, pp. 190–91, doi:<a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">10.1016/S1534-5807(03)00235-1</a>.","apa":"Montero, J., &#38; Heisenberg, C.-P. J. (2003). Adhesive crosstalk in gastrulation. <i>Developmental Cell</i>. Cell Press. <a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">https://doi.org/10.1016/S1534-5807(03)00235-1</a>","ieee":"J. Montero and C.-P. J. Heisenberg, “Adhesive crosstalk in gastrulation,” <i>Developmental Cell</i>, vol. 5, no. 2. Cell Press, pp. 190–191, 2003.","ista":"Montero J, Heisenberg C-PJ. 2003. Adhesive crosstalk in gastrulation. Developmental Cell. 5(2), 190–191.","chicago":"Montero, Juan, and Carl-Philipp J Heisenberg. “Adhesive Crosstalk in Gastrulation.” <i>Developmental Cell</i>. Cell Press, 2003. <a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">https://doi.org/10.1016/S1534-5807(03)00235-1</a>.","short":"J. Montero, C.-P.J. Heisenberg, Developmental Cell 5 (2003) 190–191.","ama":"Montero J, Heisenberg C-PJ. Adhesive crosstalk in gastrulation. <i>Developmental Cell</i>. 2003;5(2):190-191. doi:<a href=\"https://doi.org/10.1016/S1534-5807(03)00235-1\">10.1016/S1534-5807(03)00235-1</a>"},"publisher":"Cell Press","type":"journal_article","publication_status":"published","intvolume":"         5","user_id":"ea97e931-d5af-11eb-85d4-e6957dddbf17","date_updated":"2024-02-27T09:54:53Z","status":"public","title":"Adhesive crosstalk in gastrulation","author":[{"full_name":"Montero, Juan","first_name":"Juan","last_name":"Montero"},{"id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","first_name":"Carl-Philipp J","orcid":"0000-0002-0912-4566","full_name":"Heisenberg, Carl-Philipp J"}],"day":"01","article_type":"original","publication_identifier":{"eissn":["1878-1551"],"issn":["1534-5807"]},"date_published":"2003-08-01T00:00:00Z","external_id":{"pmid":["12919669 "]},"_id":"4168","pmid":1,"date_created":"2018-12-11T12:07:21Z","oa_version":"None","publist_id":"1949","extern":"1","publication":"Developmental Cell"}]