---
_id: '8073'
abstract:
- lang: eng
text: Motor cortex (M1) exhibits a rich repertoire of neuronal activities to support
the generation of complex movements. Although recent neuronal-network models capture
many qualitative aspects of M1 dynamics, they can generate only a few distinct
movements. Additionally, it is unclear how M1 efficiently controls movements over
a wide range of shapes and speeds. We demonstrate that modulation of neuronal
input–output gains in recurrent neuronal-network models with a fixed architecture
can dramatically reorganize neuronal activity and thus downstream muscle outputs.
Consistent with the observation of diffuse neuromodulatory projections to M1,
a relatively small number of modulatory control units provide sufficient flexibility
to adjust high-dimensional network activity using a simple reward-based learning
rule. Furthermore, it is possible to assemble novel movements from previously
learned primitives, and one can separately change movement speed while preserving
movement shape. Our results provide a new perspective on the role of modulatory
systems in controlling recurrent cortical activity.
article_processing_charge: No
article_type: original
author:
- first_name: Jake P.
full_name: Stroud, Jake P.
last_name: Stroud
- first_name: Mason A.
full_name: Porter, Mason A.
last_name: Porter
- first_name: Guillaume
full_name: Hennequin, Guillaume
last_name: Hennequin
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
citation:
ama: Stroud JP, Porter MA, Hennequin G, Vogels TP. Motor primitives in space and
time via targeted gain modulation in cortical networks. Nature Neuroscience.
2018;21(12):1774-1783. doi:10.1038/s41593-018-0276-0
apa: Stroud, J. P., Porter, M. A., Hennequin, G., & Vogels, T. P. (2018). Motor
primitives in space and time via targeted gain modulation in cortical networks.
Nature Neuroscience. Springer Nature. https://doi.org/10.1038/s41593-018-0276-0
chicago: Stroud, Jake P., Mason A. Porter, Guillaume Hennequin, and Tim P Vogels.
“Motor Primitives in Space and Time via Targeted Gain Modulation in Cortical Networks.”
Nature Neuroscience. Springer Nature, 2018. https://doi.org/10.1038/s41593-018-0276-0.
ieee: J. P. Stroud, M. A. Porter, G. Hennequin, and T. P. Vogels, “Motor primitives
in space and time via targeted gain modulation in cortical networks,” Nature
Neuroscience, vol. 21, no. 12. Springer Nature, pp. 1774–1783, 2018.
ista: Stroud JP, Porter MA, Hennequin G, Vogels TP. 2018. Motor primitives in space
and time via targeted gain modulation in cortical networks. Nature Neuroscience.
21(12), 1774–1783.
mla: Stroud, Jake P., et al. “Motor Primitives in Space and Time via Targeted Gain
Modulation in Cortical Networks.” Nature Neuroscience, vol. 21, no. 12,
Springer Nature, 2018, pp. 1774–83, doi:10.1038/s41593-018-0276-0.
short: J.P. Stroud, M.A. Porter, G. Hennequin, T.P. Vogels, Nature Neuroscience
21 (2018) 1774–1783.
date_created: 2020-06-30T13:18:02Z
date_published: 2018-12-01T00:00:00Z
date_updated: 2021-01-12T08:16:46Z
day: '01'
doi: 10.1038/s41593-018-0276-0
extern: '1'
external_id:
pmid:
- '30482949'
intvolume: ' 21'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276991/
month: '12'
oa: 1
oa_version: Submitted Version
page: 1774-1783
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
- 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41593-018-0307-x
status: public
title: Motor primitives in space and time via targeted gain modulation in cortical
networks
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 21
year: '2018'
...
---
_id: '6136'
abstract:
- lang: eng
text: Tonic receptors convey stimulus duration and intensity and are implicated
in homeostatic control. However, how tonic homeostatic signals are generated and
how they reconfigure neural circuits and modify animal behavior is poorly understood.
Here we show that Caenorhabditis elegans O2-sensing neurons are tonic receptors
that continuously signal ambient [O2] to set the animal's behavioral state. Sustained
signaling relied on a Ca2+ relay involving L-type voltage-gated Ca2+ channels,
the ryanodine and the inositol-1,4,5-trisphosphate receptors. Tonic activity evoked
continuous neuropeptide release, which helps elicit the enduring behavioral state
associated with high [O2]. Sustained O2 receptor signaling was propagated to downstream
neural circuits, including the hub interneuron RMG. O2 receptors evoked similar
locomotory states at particular O2 concentrations, regardless of previous d[O2]/dt.
However, a phasic component of the URX receptors' response to high d[O2]/dt, as
well as tonic-to-phasic transformations in downstream interneurons, enabled transient
reorientation movements shaped by d[O2]/dt. Our results highlight how tonic homeostatic
signals can generate both transient and enduring behavioral change.
author:
- first_name: Karl Emanuel
full_name: Busch, Karl Emanuel
last_name: Busch
- first_name: Patrick
full_name: Laurent, Patrick
last_name: Laurent
- first_name: Zoltan
full_name: Soltesz, Zoltan
last_name: Soltesz
- first_name: Robin Joseph
full_name: Murphy, Robin Joseph
last_name: Murphy
- first_name: Olivier
full_name: Faivre, Olivier
last_name: Faivre
- first_name: Berthold
full_name: Hedwig, Berthold
last_name: Hedwig
- first_name: Martin
full_name: Thomas, Martin
last_name: Thomas
- first_name: Heather L
full_name: Smith, Heather L
last_name: Smith
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Busch KE, Laurent P, Soltesz Z, et al. Tonic signaling from O2 sensors sets
neural circuit activity and behavioral state. Nature Neuroscience. 2012;15(4):581-591.
doi:10.1038/nn.3061
apa: Busch, K. E., Laurent, P., Soltesz, Z., Murphy, R. J., Faivre, O., Hedwig,
B., … de Bono, M. (2012). Tonic signaling from O2 sensors sets neural circuit
activity and behavioral state. Nature Neuroscience. Springer Nature. https://doi.org/10.1038/nn.3061
chicago: Busch, Karl Emanuel, Patrick Laurent, Zoltan Soltesz, Robin Joseph Murphy,
Olivier Faivre, Berthold Hedwig, Martin Thomas, Heather L Smith, and Mario de
Bono. “Tonic Signaling from O2 Sensors Sets Neural Circuit Activity and Behavioral
State.” Nature Neuroscience. Springer Nature, 2012. https://doi.org/10.1038/nn.3061.
ieee: K. E. Busch et al., “Tonic signaling from O2 sensors sets neural circuit
activity and behavioral state,” Nature Neuroscience, vol. 15, no. 4. Springer
Nature, pp. 581–591, 2012.
ista: Busch KE, Laurent P, Soltesz Z, Murphy RJ, Faivre O, Hedwig B, Thomas M, Smith
HL, de Bono M. 2012. Tonic signaling from O2 sensors sets neural circuit activity
and behavioral state. Nature Neuroscience. 15(4), 581–591.
mla: Busch, Karl Emanuel, et al. “Tonic Signaling from O2 Sensors Sets Neural Circuit
Activity and Behavioral State.” Nature Neuroscience, vol. 15, no. 4, Springer
Nature, 2012, pp. 581–91, doi:10.1038/nn.3061.
short: K.E. Busch, P. Laurent, Z. Soltesz, R.J. Murphy, O. Faivre, B. Hedwig, M.
Thomas, H.L. Smith, M. de Bono, Nature Neuroscience 15 (2012) 581–591.
date_created: 2019-03-20T14:23:30Z
date_published: 2012-03-04T00:00:00Z
date_updated: 2021-01-12T08:06:17Z
day: '04'
doi: 10.1038/nn.3061
extern: '1'
external_id:
pmid:
- '22388961'
intvolume: ' 15'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564487/
month: '03'
oa: 1
oa_version: Submitted Version
page: 581-591
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
- 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Tonic signaling from O2 sensors sets neural circuit activity and behavioral
state
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2012'
...
---
_id: '3258'
abstract:
- lang: eng
text: CA3 pyramidal neurons are important for memory formation and pattern completion
in the hippocampal network. It is generally thought that proximal synapses from
the mossy fibers activate these neurons most efficiently, whereas distal inputs
from the perforant path have a weaker modulatory influence. We used confocally
targeted patch-clamp recording from dendrites and axons to map the activation
of rat CA3 pyramidal neurons at the subcellular level. Our results reveal two
distinct dendritic domains. In the proximal domain, action potentials initiated
in the axon backpropagate actively with large amplitude and fast time course.
In the distal domain, Na+ channel–mediated dendritic spikes are efficiently initiated
by waveforms mimicking synaptic events. CA3 pyramidal neuron dendrites showed
a high Na+-to-K+ conductance density ratio, providing ideal conditions for active
backpropagation and dendritic spike initiation. Dendritic spikes may enhance the
computational power of CA3 pyramidal neurons in the hippocampal network.
acknowledgement: This work was supported by the Deutsche Forschungsgemeinschaft (TR
3/B10) and the European Union (European Research Council Advanced grant to P.J.).
article_processing_charge: No
article_type: original
author:
- first_name: Sooyun
full_name: Kim, Sooyun
id: 394AB1C8-F248-11E8-B48F-1D18A9856A87
last_name: Kim
- first_name: José
full_name: Guzmán, José
id: 30CC5506-F248-11E8-B48F-1D18A9856A87
last_name: Guzmán
orcid: 0000-0003-2209-5242
- first_name: Hua
full_name: Hu, Hua
id: 4AC0145C-F248-11E8-B48F-1D18A9856A87
last_name: Hu
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
citation:
ama: Kim S, Guzmán J, Hu H, Jonas PM. Active dendrites support efficient initiation
of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience.
2012;15(4):600-606. doi:10.1038/nn.3060
apa: Kim, S., Guzmán, J., Hu, H., & Jonas, P. M. (2012). Active dendrites support
efficient initiation of dendritic spikes in hippocampal CA3 pyramidal neurons.
Nature Neuroscience. Nature Publishing Group. https://doi.org/10.1038/nn.3060
chicago: Kim, Sooyun, José Guzmán, Hua Hu, and Peter M Jonas. “Active Dendrites
Support Efficient Initiation of Dendritic Spikes in Hippocampal CA3 Pyramidal
Neurons.” Nature Neuroscience. Nature Publishing Group, 2012. https://doi.org/10.1038/nn.3060.
ieee: S. Kim, J. Guzmán, H. Hu, and P. M. Jonas, “Active dendrites support efficient
initiation of dendritic spikes in hippocampal CA3 pyramidal neurons,” Nature
Neuroscience, vol. 15, no. 4. Nature Publishing Group, pp. 600–606, 2012.
ista: Kim S, Guzmán J, Hu H, Jonas PM. 2012. Active dendrites support efficient
initiation of dendritic spikes in hippocampal CA3 pyramidal neurons. Nature Neuroscience.
15(4), 600–606.
mla: Kim, Sooyun, et al. “Active Dendrites Support Efficient Initiation of Dendritic
Spikes in Hippocampal CA3 Pyramidal Neurons.” Nature Neuroscience, vol.
15, no. 4, Nature Publishing Group, 2012, pp. 600–06, doi:10.1038/nn.3060.
short: S. Kim, J. Guzmán, H. Hu, P.M. Jonas, Nature Neuroscience 15 (2012) 600–606.
corr_author: '1'
date_created: 2018-12-11T12:02:18Z
date_published: 2012-04-01T00:00:00Z
date_updated: 2026-04-09T14:36:04Z
day: '01'
department:
- _id: PeJo
doi: 10.1038/nn.3060
external_id:
isi:
- '000302114500020'
pmid:
- '22388958'
intvolume: ' 15'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3617474/
month: '04'
oa: 1
oa_version: Published Version
page: 600 - 606
pmid: 1
project:
- _id: 25BDE9A4-B435-11E9-9278-68D0E5697425
grant_number: SFB-TR3-TP10B
name: "Glutamaterge synaptische Ã\x9Cbertragung und Plastizität in hippocampalen
Mikroschaltkreisen"
publication: Nature Neuroscience
publication_identifier:
issn:
- 1546-1726
publication_status: published
publisher: Nature Publishing Group
publist_id: '3390'
quality_controlled: '1'
related_material:
record:
- id: '2964'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Active dendrites support efficient initiation of dendritic spikes in hippocampal
CA3 pyramidal neurons
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 15
year: '2012'
...
---
_id: '8026'
abstract:
- lang: eng
text: Recent theoretical work has provided a basic understanding of signal propagation
in networks of spiking neurons, but mechanisms for gating and controlling these
signals have not been investigated previously. Here we introduce an idea for the
gating of multiple signals in cortical networks that combines principles of signal
propagation with aspects of balanced networks. Specifically, we studied networks
in which incoming excitatory signals are normally cancelled by locally evoked
inhibition, leaving the targeted layer unresponsive. Transmission can be gated
'on' by modulating excitatory and inhibitory gains to upset this detailed balance.
We illustrate gating through detailed balance in large networks of integrate-and-fire
neurons. We show successful gating of multiple signals and study failure modes
that produce effects reminiscent of clinically observed pathologies. Provided
that the individual signals are detectable, detailed balance has a large capacity
for gating multiple signals.
article_processing_charge: No
article_type: original
author:
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
- first_name: L F
full_name: Abbott, L F
last_name: Abbott
citation:
ama: Vogels TP, Abbott LF. Gating multiple signals through detailed balance of excitation
and inhibition in spiking networks. Nature Neuroscience. 2009;12(4):483-491.
doi:10.1038/nn.2276
apa: Vogels, T. P., & Abbott, L. F. (2009). Gating multiple signals through
detailed balance of excitation and inhibition in spiking networks. Nature Neuroscience.
Springer Nature. https://doi.org/10.1038/nn.2276
chicago: Vogels, Tim P, and L F Abbott. “Gating Multiple Signals through Detailed
Balance of Excitation and Inhibition in Spiking Networks.” Nature Neuroscience.
Springer Nature, 2009. https://doi.org/10.1038/nn.2276.
ieee: T. P. Vogels and L. F. Abbott, “Gating multiple signals through detailed balance
of excitation and inhibition in spiking networks,” Nature Neuroscience,
vol. 12, no. 4. Springer Nature, pp. 483–491, 2009.
ista: Vogels TP, Abbott LF. 2009. Gating multiple signals through detailed balance
of excitation and inhibition in spiking networks. Nature Neuroscience. 12(4),
483–491.
mla: Vogels, Tim P., and L. F. Abbott. “Gating Multiple Signals through Detailed
Balance of Excitation and Inhibition in Spiking Networks.” Nature Neuroscience,
vol. 12, no. 4, Springer Nature, 2009, pp. 483–91, doi:10.1038/nn.2276.
short: T.P. Vogels, L.F. Abbott, Nature Neuroscience 12 (2009) 483–491.
date_created: 2020-06-25T13:10:55Z
date_published: 2009-04-01T00:00:00Z
date_updated: 2021-01-12T08:16:36Z
day: '01'
doi: 10.1038/nn.2276
extern: '1'
external_id:
pmid:
- '19305402'
intvolume: ' 12'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693069/
month: '04'
oa: 1
oa_version: Submitted Version
page: 483-491
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
- 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Gating multiple signals through detailed balance of excitation and inhibition
in spiking networks
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 12
year: '2009'
...
---
_id: '6156'
abstract:
- lang: eng
text: 'Social and solitary feeding in natural Caenorhabditis elegans isolates are
associated with two alleles of the orphan G-protein-coupled receptor (GPCR) NPR-1:
social feeders contain NPR-1 215F, whereas solitary feeders contain NPR-1 215V.
Here we identify FMRFamide-related neuropeptides (FaRPs) encoded by the flp-18
and flp-21 genes as NPR-1 ligands and show that these peptides can differentially
activate the NPR-1 215F and NPR-1 215V receptors. Multicopy overexpression of
flp-21 transformed wild social animals into solitary feeders. Conversely, a flp-21
deletion partially phenocopied the npr-1(null) phenotype, which is consistent
with NPR-1 activation by FLP-21 in vivo but also implicates other ligands for
NPR-1. Phylogenetic studies indicate that the dominant npr-1 215V allele likely
arose from an ancestral npr-1 215F gene in C. elegans. Our data suggest a model
in which solitary feeding evolved in an ancestral social strain of C. elegans
by a gain-of-function mutation that modified the response of NPR-1 to FLP-18 and
FLP-21 ligands.'
author:
- first_name: Candida
full_name: Rogers, Candida
last_name: Rogers
- first_name: Vincenzina
full_name: Reale, Vincenzina
last_name: Reale
- first_name: Kyuhyung
full_name: Kim, Kyuhyung
last_name: Kim
- first_name: Heather
full_name: Chatwin, Heather
last_name: Chatwin
- first_name: Chris
full_name: Li, Chris
last_name: Li
- first_name: Peter
full_name: Evans, Peter
last_name: Evans
- first_name: Mario
full_name: de Bono, Mario
id: 4E3FF80E-F248-11E8-B48F-1D18A9856A87
last_name: de Bono
orcid: 0000-0001-8347-0443
citation:
ama: Rogers C, Reale V, Kim K, et al. Inhibition of Caenorhabditis elegans social
feeding by FMRFamide-related peptide activation of NPR-1. Nature Neuroscience.
2003;6(11):1178-1185. doi:10.1038/nn1140
apa: Rogers, C., Reale, V., Kim, K., Chatwin, H., Li, C., Evans, P., & de Bono,
M. (2003). Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related
peptide activation of NPR-1. Nature Neuroscience. Springer Nature. https://doi.org/10.1038/nn1140
chicago: Rogers, Candida, Vincenzina Reale, Kyuhyung Kim, Heather Chatwin, Chris
Li, Peter Evans, and Mario de Bono. “Inhibition of Caenorhabditis Elegans Social
Feeding by FMRFamide-Related Peptide Activation of NPR-1.” Nature Neuroscience.
Springer Nature, 2003. https://doi.org/10.1038/nn1140.
ieee: C. Rogers et al., “Inhibition of Caenorhabditis elegans social feeding
by FMRFamide-related peptide activation of NPR-1,” Nature Neuroscience,
vol. 6, no. 11. Springer Nature, pp. 1178–1185, 2003.
ista: Rogers C, Reale V, Kim K, Chatwin H, Li C, Evans P, de Bono M. 2003. Inhibition
of Caenorhabditis elegans social feeding by FMRFamide-related peptide activation
of NPR-1. Nature Neuroscience. 6(11), 1178–1185.
mla: Rogers, Candida, et al. “Inhibition of Caenorhabditis Elegans Social Feeding
by FMRFamide-Related Peptide Activation of NPR-1.” Nature Neuroscience,
vol. 6, no. 11, Springer Nature, 2003, pp. 1178–85, doi:10.1038/nn1140.
short: C. Rogers, V. Reale, K. Kim, H. Chatwin, C. Li, P. Evans, M. de Bono, Nature
Neuroscience 6 (2003) 1178–1185.
date_created: 2019-03-21T09:47:53Z
date_published: 2003-10-12T00:00:00Z
date_updated: 2021-01-12T08:06:25Z
day: '12'
doi: 10.1038/nn1140
extern: '1'
external_id:
pmid:
- '14555955'
intvolume: ' 6'
issue: '11'
language:
- iso: eng
month: '10'
oa_version: None
page: 1178-1185
pmid: 1
publication: Nature Neuroscience
publication_identifier:
issn:
- 1097-6256
- 1546-1726
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Inhibition of Caenorhabditis elegans social feeding by FMRFamide-related peptide
activation of NPR-1
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2003'
...