[{"DOAJ_listed":"1","type":"journal_article","external_id":{"pmid":["42088272"]},"doi":"10.3389/fmicb.2026.1793713","volume":17,"has_accepted_license":"1","publication_identifier":{"issn":["1664-302X"]},"quality_controlled":"1","month":"04","article_type":"original","author":[{"full_name":"Tocino-Márquez, Inmaculada","last_name":"Tocino-Márquez","first_name":"Inmaculada"},{"id":"8e016d5b-5d77-11f0-86d2-96cdb3922a55","orcid":"0000-0001-9685-0373","full_name":"Zehl, Martin","last_name":"Zehl","first_name":"Martin"},{"full_name":"Batajic, Jovana","first_name":"Jovana","last_name":"Batajic"},{"first_name":"Joana","last_name":"Séneca","full_name":"Séneca, Joana"},{"full_name":"Pjevac, Petra","last_name":"Pjevac","first_name":"Petra"},{"first_name":"José","last_name":"Murillo-Alba","full_name":"Murillo-Alba, José"},{"first_name":"Jesús","last_name":"Martín","full_name":"Martín, Jesús"},{"last_name":"Sekurova","first_name":"Olga N.","full_name":"Sekurova, Olga N."},{"last_name":"Zotchev","first_name":"Sergey B.","full_name":"Zotchev, Sergey B."}],"OA_place":"publisher","acknowledgement":"The computational results of this work have been achieved using the Life Science Compute Cluster (LiSC) of the University of Vienna. We additionally thank Julia Ramesmayer for assistance during DNA extraction and sample preparation for long-read sequencing. Support from the Mass Spectrometry Centre of the Faculty of Chemistry, University of Vienna, is thankfully acknowledged.\r\nThe author(s) declared that financial support was received for this work and/or its publication. This work was supported by the University of Vienna via the Research Platform Secondary Metabolomes of Bacterial Communities (MetaBac). Open access funding provided by University of Vienna. ","department":[{"_id":"MassSpec"}],"ddc":["572"],"publication":"Frontiers in Microbiology","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","image":"/images/cc_by.png","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"PlanS_conform":"1","file":[{"date_created":"2026-06-10T07:46:30Z","file_id":"21989","file_name":"2026_FrontiersMicrobiology_TocinoMarquez.pdf","creator":"dernst","file_size":3582644,"access_level":"open_access","success":1,"date_updated":"2026-06-10T07:46:30Z","content_type":"application/pdf","checksum":"31fb6b98c8a6d4007cb21808c6d2d9e3","relation":"main_file"}],"publisher":"Frontiers Media","citation":{"ama":"Tocino-Márquez I, Zehl M, Batajic J, et al. Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments. <i>Frontiers in Microbiology</i>. 2026;17. doi:<a href=\"https://doi.org/10.3389/fmicb.2026.1793713\">10.3389/fmicb.2026.1793713</a>","ieee":"I. Tocino-Márquez <i>et al.</i>, “Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments,” <i>Frontiers in Microbiology</i>, vol. 17. Frontiers Media, 2026.","chicago":"Tocino-Márquez, Inmaculada, Martin Zehl, Jovana Batajic, Joana Séneca, Petra Pjevac, José Murillo-Alba, Jesús Martín, Olga N. Sekurova, and Sergey B. Zotchev. “Unveiling the Genomes and Secondary Metabolomes of Streptomyces Spp. from Freshwater Sediments.” <i>Frontiers in Microbiology</i>. Frontiers Media, 2026. <a href=\"https://doi.org/10.3389/fmicb.2026.1793713\">https://doi.org/10.3389/fmicb.2026.1793713</a>.","ista":"Tocino-Márquez I, Zehl M, Batajic J, Séneca J, Pjevac P, Murillo-Alba J, Martín J, Sekurova ON, Zotchev SB. 2026. Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments. Frontiers in Microbiology. 17, 1793713.","short":"I. Tocino-Márquez, M. Zehl, J. Batajic, J. Séneca, P. Pjevac, J. Murillo-Alba, J. Martín, O.N. Sekurova, S.B. Zotchev, Frontiers in Microbiology 17 (2026).","mla":"Tocino-Márquez, Inmaculada, et al. “Unveiling the Genomes and Secondary Metabolomes of Streptomyces Spp. from Freshwater Sediments.” <i>Frontiers in Microbiology</i>, vol. 17, 1793713, Frontiers Media, 2026, doi:<a href=\"https://doi.org/10.3389/fmicb.2026.1793713\">10.3389/fmicb.2026.1793713</a>.","apa":"Tocino-Márquez, I., Zehl, M., Batajic, J., Séneca, J., Pjevac, P., Murillo-Alba, J., … Zotchev, S. B. (2026). Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments. <i>Frontiers in Microbiology</i>. Frontiers Media. <a href=\"https://doi.org/10.3389/fmicb.2026.1793713\">https://doi.org/10.3389/fmicb.2026.1793713</a>"},"intvolume":"        17","article_number":"1793713","file_date_updated":"2026-06-10T07:46:30Z","day":"20","date_published":"2026-04-20T00:00:00Z","article_processing_charge":"Yes","title":"Unveiling the genomes and secondary metabolomes of Streptomyces spp. from freshwater sediments","_id":"21953","status":"public","abstract":[{"lang":"eng","text":"Several Streptomyces strains were isolated from freshwater sediments collected in the Laxenburg ponds (Lower Austria). Genome sequencing and bioinformatics analyses revealed biosynthetic gene clusters (BGCs) that may specify production of chemically diverse secondary metabolites. Various culture conditions were employed to induce metabolite production, and subsequent LC-MS analyses facilitated the identification of the produced compounds and their correlation with the corresponding BGCs. These analyses of sediment-derived Streptomyces spp. highlight their extensive biosynthetic potential, revealing a diverse range of bioactive secondary metabolites, including siderophores, antibiotics, and other compounds with potential therapeutic applications. Genomes of two Streptomyces isolates, one of them representing a potentially new species, harbored several uncharacterized BGCs that may specify biosynthesis of novel secondary metabolites. Although targeted overexpression of pathway-specific regulators from these BGCs did not yield additional metabolites, whereas knockout experiments led to metabolic changes, presumably reflecting regulatory or compensatory interactions between multiple biosynthetic pathways. Continued exploration of these strains and their BGCs may lead to the discovery of new bioactive molecules with pharmaceutical and biotechnological applications."}],"oa":1,"date_created":"2026-06-08T08:34:10Z","oa_version":"Published Version","date_updated":"2026-06-10T07:49:04Z","pmid":1,"year":"2026","publication_status":"published","OA_type":"gold","license":"https://creativecommons.org/licenses/by/4.0/"}]