[{"intvolume":"        22","isi":1,"acknowledgement":"We acknowledge Prof. Uri Alon for introducing us to the topic of systems biology during the graduate course at the Weizmann Institute of Science, whose insights and teachings have greatly inspired this work.","corr_author":"1","author":[{"full_name":"Ayalon, Oran","last_name":"Ayalon","first_name":"Oran"},{"full_name":"Rajendran, Harikrishnan","last_name":"Rajendran","first_name":"Harikrishnan","id":"876b6b34-8ff4-11ec-97c9-8d95a7aae416"}],"status":"public","quality_controlled":"1","oa_version":"None","department":[{"_id":"SyCr"}],"OA_type":"closed access","date_published":"2025-08-13T00:00:00Z","external_id":{"pmid":["40799050"],"isi":["001548084900001"]},"issue":"229","day":"13","scopus_import":"1","language":[{"iso":"eng"}],"article_processing_charge":"No","month":"08","doi":"10.1098/rsif.2025.0202","type":"journal_article","date_created":"2025-08-24T22:01:30Z","article_number":"20250202","publication_status":"published","article_type":"original","abstract":[{"lang":"eng","text":"Reproduction is a fundamental biological process, with organisms reproducing sexually, asexually, and, in some cases, utilizing both modes of reproduction within the same population. Does the ability to reproduce through a combination of asexual and sexual modes offer an evolutionary advantage over relying on either mode alone? Here, we introduce an empirically driven theoretical model to examine the dynamics and interplay between sexual and asexual reproduction in stick insect populations. We analyse it using a novel phase transition approach and corroborate it using published experimental data. We find that the presence of males can either increase or decrease the overall population size. However, maintaining an optimal ratio of parthenogenetic to sexual reproduction is crucial for male resilience, effectively delaying male extinction. Conversely, extreme levels of parthenogenetic reproduction—whether too high or too low—can lead to male extinction, emphasizing the need for a balanced number of virgin females to ensure the persistence of males. Our model also explains male absence in Carausius morosus and persistence in Extatosoma tiaratum. Our findings provide valuable insights into the interplay of reproductive strategies and contribute to broader discussions on the transitions between sexual and asexual reproduction."}],"volume":22,"publication":"Journal of the Royal Society Interface","_id":"20219","date_updated":"2026-08-12T14:09:20Z","pmid":1,"publication_identifier":{"issn":["1742-5689"],"eissn":["1742-5662"]},"citation":{"ama":"Ayalon O, Rajendran H. Interplay of asexual and sexual reproduction in bifunctional insects. <i>Journal of the Royal Society Interface</i>. 2025;22(229). doi:<a href=\"https://doi.org/10.1098/rsif.2025.0202\">10.1098/rsif.2025.0202</a>","ieee":"O. Ayalon and H. Rajendran, “Interplay of asexual and sexual reproduction in bifunctional insects,” <i>Journal of the Royal Society Interface</i>, vol. 22, no. 229. Royal Society, 2025.","short":"O. Ayalon, H. Rajendran, Journal of the Royal Society Interface 22 (2025).","mla":"Ayalon, Oran, and Harikrishnan Rajendran. “Interplay of Asexual and Sexual Reproduction in Bifunctional Insects.” <i>Journal of the Royal Society Interface</i>, vol. 22, no. 229, 20250202, Royal Society, 2025, doi:<a href=\"https://doi.org/10.1098/rsif.2025.0202\">10.1098/rsif.2025.0202</a>.","ista":"Ayalon O, Rajendran H. 2025. Interplay of asexual and sexual reproduction in bifunctional insects. Journal of the Royal Society Interface. 22(229), 20250202.","chicago":"Ayalon, Oran, and Harikrishnan Rajendran. “Interplay of Asexual and Sexual Reproduction in Bifunctional Insects.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2025. <a href=\"https://doi.org/10.1098/rsif.2025.0202\">https://doi.org/10.1098/rsif.2025.0202</a>.","apa":"Ayalon, O., &#38; Rajendran, H. (2025). Interplay of asexual and sexual reproduction in bifunctional insects. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2025.0202\">https://doi.org/10.1098/rsif.2025.0202</a>"},"title":"Interplay of asexual and sexual reproduction in bifunctional insects","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Royal Society","year":"2025"},{"date_created":"2020-04-08T15:19:17Z","type":"journal_article","ddc":["570"],"file":[{"file_id":"7660","checksum":"4eb102304402f5c56432516b84df86d6","file_name":"2020_JournRoyalSociety_Larsson.pdf","file_size":1556190,"relation":"main_file","access_level":"open_access","content_type":"application/pdf","date_updated":"2020-07-14T12:48:01Z","date_created":"2020-04-14T12:31:16Z","creator":"dernst"}],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"abstract":[{"text":"The growth of snail shells can be described by simple mathematical rules. Variation in a few parameters can explain much of the diversity of shell shapes seen in nature. However, empirical studies of gastropod shell shape variation typically use geometric morphometric approaches, which do not capture this growth pattern. We have developed a way to infer a set of developmentally descriptive shape parameters based on three-dimensional logarithmic helicospiral growth and using landmarks from two-dimensional shell images as input. We demonstrate the utility of this approach, and compare it to the geometric morphometric approach, using a large set of Littorina saxatilis shells in which locally adapted populations differ in shape. Our method can be modified easily to make it applicable to a wide range of shell forms, which would allow for investigations of the similarities and differences between and within many different species of gastropods.","lang":"eng"}],"article_type":"original","publication_status":"published","article_number":"20190721","publication":"Journal of the Royal Society Interface","volume":17,"date_updated":"2026-08-12T14:06:19Z","_id":"7651","citation":{"ieee":"J. Larsson, A. M. Westram, S. Bengmark, T. Lundh, and R. K. Butlin, “A developmentally descriptive method for quantifying shape in gastropod shells,” <i>Journal of the Royal Society Interface</i>, vol. 17, no. 163. Royal Society, 2020.","short":"J. Larsson, A.M. Westram, S. Bengmark, T. Lundh, R.K. Butlin, Journal of the Royal Society Interface 17 (2020).","mla":"Larsson, J., et al. “A Developmentally Descriptive Method for Quantifying Shape in Gastropod Shells.” <i>Journal of the Royal Society Interface</i>, vol. 17, no. 163, 20190721, Royal Society, 2020, doi:<a href=\"https://doi.org/10.1098/rsif.2019.0721\">10.1098/rsif.2019.0721</a>.","ista":"Larsson J, Westram AM, Bengmark S, Lundh T, Butlin RK. 2020. A developmentally descriptive method for quantifying shape in gastropod shells. Journal of the Royal Society Interface. 17(163), 20190721.","chicago":"Larsson, J., Anja M Westram, S. Bengmark, T. Lundh, and R. K. Butlin. “A Developmentally Descriptive Method for Quantifying Shape in Gastropod Shells.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2020. <a href=\"https://doi.org/10.1098/rsif.2019.0721\">https://doi.org/10.1098/rsif.2019.0721</a>.","apa":"Larsson, J., Westram, A. M., Bengmark, S., Lundh, T., &#38; Butlin, R. K. (2020). A developmentally descriptive method for quantifying shape in gastropod shells. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2019.0721\">https://doi.org/10.1098/rsif.2019.0721</a>","ama":"Larsson J, Westram AM, Bengmark S, Lundh T, Butlin RK. A developmentally descriptive method for quantifying shape in gastropod shells. <i>Journal of the Royal Society Interface</i>. 2020;17(163). doi:<a href=\"https://doi.org/10.1098/rsif.2019.0721\">10.1098/rsif.2019.0721</a>"},"publication_identifier":{"eissn":["1742-5662"],"issn":["1742-5689"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Royal Society","title":"A developmentally descriptive method for quantifying shape in gastropod shells","year":"2020","intvolume":"        17","author":[{"first_name":"J.","full_name":"Larsson, J.","last_name":"Larsson"},{"id":"3C147470-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1050-4969","last_name":"Westram","full_name":"Westram, Anja M","first_name":"Anja M"},{"first_name":"S.","last_name":"Bengmark","full_name":"Bengmark, S."},{"first_name":"T.","last_name":"Lundh","full_name":"Lundh, T."},{"first_name":"R. K.","full_name":"Butlin, R. K.","last_name":"Butlin"}],"oa_version":"Published Version","department":[{"_id":"NiBa"}],"status":"public","quality_controlled":"1","date_published":"2020-02-01T00:00:00Z","oa":1,"has_accepted_license":"1","issue":"163","article_processing_charge":"No","language":[{"iso":"eng"}],"scopus_import":"1","day":"01","file_date_updated":"2020-07-14T12:48:01Z","month":"02","doi":"10.1098/rsif.2019.0721"},{"oa":1,"external_id":{"isi":["000456783800011"]},"date_published":"2018-12-05T00:00:00Z","oa_version":"Published Version","department":[{"_id":"MiSi"}],"quality_controlled":"1","status":"public","author":[{"last_name":"Hross","full_name":"Hross, Sabrina","first_name":"Sabrina"},{"first_name":"Fabian J.","last_name":"Theis","full_name":"Theis, Fabian J."},{"id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","first_name":"Michael K"},{"last_name":"Hasenauer","full_name":"Hasenauer, Jan","first_name":"Jan"}],"isi":1,"intvolume":"        15","doi":"10.1098/rsif.2018.0600","month":"12","file_date_updated":"2020-07-14T12:47:13Z","day":"05","article_processing_charge":"No","language":[{"iso":"eng"}],"scopus_import":"1","issue":"149","has_accepted_license":"1","volume":15,"publication":"Journal of the Royal Society Interface","publication_status":"published","article_number":"20180600","abstract":[{"text":"Spatial patterns are ubiquitous on the subcellular, cellular and tissue level, and can be studied using imaging techniques such as light and fluorescence microscopy. Imaging data provide quantitative information about biological systems; however, mechanisms causing spatial patterning often remain elusive. In recent years, spatio-temporal mathematical modelling has helped to overcome this problem. Yet, outliers and structured noise limit modelling of whole imaging data, and models often consider spatial summary statistics. Here, we introduce an integrated data-driven modelling approach that can cope with measurement artefacts and whole imaging data. Our approach combines mechanistic models of the biological processes with robust statistical models of the measurement process. The parameters of the integrated model are calibrated using a maximum-likelihood approach. We used this integrated modelling approach to study in vivo gradients of the chemokine (C-C motif) ligand 21 (CCL21). CCL21 gradients guide dendritic cells and are important in the adaptive immune response. Using artificial data, we verified that the integrated modelling approach provides reliable parameter estimates in the presence of measurement noise and that bias and variance of these estimates are reduced compared to conventional approaches. The application to experimental data allowed the parametrization and subsequent refinement of the model using additional mechanisms. Among other results, model-based hypothesis testing predicted lymphatic vessel-dependent concentration of heparan sulfate, the binding partner of CCL21. The selected model provided an accurate description of the experimental data and was partially validated using published data. Our findings demonstrate that integrated statistical modelling of whole imaging data is computationally feasible and can provide novel biological insights.","lang":"eng"}],"file":[{"relation":"main_file","file_size":1464288,"access_level":"open_access","file_id":"5925","file_name":"2018_Interface_Hross.pdf","checksum":"56eb4308a15b7190bff938fab1f780e8","creator":"dernst","content_type":"application/pdf","date_updated":"2020-07-14T12:47:13Z","date_created":"2019-02-05T14:46:44Z"}],"ddc":["570"],"tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"type":"journal_article","date_created":"2019-01-20T22:59:18Z","year":"2018","publisher":"Royal Society","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data","publication_identifier":{"issn":["1742-5689"]},"citation":{"mla":"Hross, Sabrina, et al. “Mechanistic Description of Spatial Processes Using Integrative Modelling of Noise-Corrupted Imaging Data.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149, 20180600, Royal Society, 2018, doi:<a href=\"https://doi.org/10.1098/rsif.2018.0600\">10.1098/rsif.2018.0600</a>.","ista":"Hross S, Theis FJ, Sixt MK, Hasenauer J. 2018. Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data. Journal of the Royal Society Interface. 15(149), 20180600.","ieee":"S. Hross, F. J. Theis, M. K. Sixt, and J. Hasenauer, “Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data,” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149. Royal Society, 2018.","short":"S. Hross, F.J. Theis, M.K. Sixt, J. Hasenauer, Journal of the Royal Society Interface 15 (2018).","apa":"Hross, S., Theis, F. J., Sixt, M. K., &#38; Hasenauer, J. (2018). Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2018.0600\">https://doi.org/10.1098/rsif.2018.0600</a>","chicago":"Hross, Sabrina, Fabian J. Theis, Michael K Sixt, and Jan Hasenauer. “Mechanistic Description of Spatial Processes Using Integrative Modelling of Noise-Corrupted Imaging Data.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2018. <a href=\"https://doi.org/10.1098/rsif.2018.0600\">https://doi.org/10.1098/rsif.2018.0600</a>.","ama":"Hross S, Theis FJ, Sixt MK, Hasenauer J. Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data. <i>Journal of the Royal Society Interface</i>. 2018;15(149). doi:<a href=\"https://doi.org/10.1098/rsif.2018.0600\">10.1098/rsif.2018.0600</a>"},"_id":"5858","date_updated":"2026-08-12T06:28:50Z"},{"day":"12","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1612.01605"}],"scopus_import":"1","article_processing_charge":"No","language":[{"iso":"eng"}],"issue":"149","doi":"10.1098/rsif.2018.0395","month":"12","arxiv":1,"author":[{"id":"43BE2298-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9806-5643","full_name":"Corominas-Murtra, Bernat","last_name":"Corominas-Murtra","first_name":"Bernat"},{"last_name":"Seoane","full_name":"Seoane, Luís F.","first_name":"Luís F."},{"last_name":"Solé","full_name":"Solé, Ricard","first_name":"Ricard"}],"intvolume":"        15","isi":1,"oa":1,"date_published":"2018-12-12T00:00:00Z","external_id":{"arxiv":["1612.01605"],"isi":["000456783800002"]},"quality_controlled":"1","status":"public","oa_version":"Preprint","department":[{"_id":"EdHa"}],"publication_identifier":{"issn":["1742-5689"]},"citation":{"chicago":"Corominas-Murtra, Bernat, Luís F. Seoane, and Ricard Solé. “Zipf’s Law, Unbounded Complexity and Open-Ended Evolution.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2018. <a href=\"https://doi.org/10.1098/rsif.2018.0395\">https://doi.org/10.1098/rsif.2018.0395</a>.","apa":"Corominas-Murtra, B., Seoane, L. F., &#38; Solé, R. (2018). Zipf’s Law, unbounded complexity and open-ended evolution. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2018.0395\">https://doi.org/10.1098/rsif.2018.0395</a>","ieee":"B. Corominas-Murtra, L. F. Seoane, and R. Solé, “Zipf’s Law, unbounded complexity and open-ended evolution,” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149. Royal Society, 2018.","short":"B. Corominas-Murtra, L.F. Seoane, R. Solé, Journal of the Royal Society Interface 15 (2018).","mla":"Corominas-Murtra, Bernat, et al. “Zipf’s Law, Unbounded Complexity and Open-Ended Evolution.” <i>Journal of the Royal Society Interface</i>, vol. 15, no. 149, 20180395, Royal Society, 2018, doi:<a href=\"https://doi.org/10.1098/rsif.2018.0395\">10.1098/rsif.2018.0395</a>.","ista":"Corominas-Murtra B, Seoane LF, Solé R. 2018. Zipf’s Law, unbounded complexity and open-ended evolution. Journal of the Royal Society Interface. 15(149), 20180395.","ama":"Corominas-Murtra B, Seoane LF, Solé R. Zipf’s Law, unbounded complexity and open-ended evolution. <i>Journal of the Royal Society Interface</i>. 2018;15(149). doi:<a href=\"https://doi.org/10.1098/rsif.2018.0395\">10.1098/rsif.2018.0395</a>"},"_id":"5860","date_updated":"2026-08-12T06:28:34Z","year":"2018","title":"Zipf's Law, unbounded complexity and open-ended evolution","publisher":"Royal Society","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","type":"journal_article","date_created":"2019-01-20T22:59:19Z","volume":15,"publication":"Journal of the Royal Society Interface","article_number":"20180395","publication_status":"published","abstract":[{"lang":"eng","text":"A major problem for evolutionary theory is understanding the so-called open-ended nature of evolutionary change, from its definition to its origins. Open-ended evolution (OEE) refers to the unbounded increase in complexity that seems to characterize evolution on multiple scales. This property seems to be a characteristic feature of biological and technological evolution and is strongly tied to the generative potential associated with combinatorics, which allows the system to grow and expand their available state spaces. Interestingly, many complex systems presumably displaying OEE, from language to proteins, share a common statistical property: the presence of Zipf's Law. Given an inventory of basic items (such as words or protein domains) required to build more complex structures (sentences or proteins) Zipf's Law tells us that most of these elements are rare whereas a few of them are extremely common. Using algorithmic information theory, in this paper we provide a fundamental definition for open-endedness, which can be understood as postulates. Its statistical counterpart, based on standard Shannon information theory, has the structure of a variational problem which is shown to lead to Zipf's Law as the expected consequence of an evolutionary process displaying OEE. We further explore the problem of information conservation through an OEE process and we conclude that statistical information (standard Shannon information) is not conserved, resulting in the paradoxical situation in which the increase of information content has the effect of erasing itself. We prove that this paradox is solved if we consider non-statistical forms of information. This last result implies that standard information theory may not be a suitable theoretical framework to explore the persistence and increase of the information content in OEE systems."}]},{"article_number":"20160139","publication_status":"published","abstract":[{"text":"Viral capsids are structurally constrained by interactions among the amino acids (AAs) of their constituent proteins. Therefore, epistasis is expected to evolve among physically interacting sites and to influence the rates of substitution. To study the evolution of epistasis, we focused on the major structural protein of the fX174 phage family by first reconstructing the ancestral protein sequences of 18 species using a Bayesian statistical framework. The inferred ancestral reconstruction differed at eight AAs, for a total of 256 possible ancestral haplotypes. For each ancestral haplotype and the extant species, we estimated, in silico, the distribution of free energies and epistasis of the capsid structure. We found that free energy has not significantly increased but epistasis has. We decomposed epistasis up to fifth order and found that higher-order epistasis sometimes compensates pairwise interactions making the free energy seem additive. The dN/dS ratio is low, suggesting strong purifying selection, and that structure is under stabilizing selection. We synthesized phages carrying ancestral haplotypes of the coat protein gene and measured their fitness experimentally. Our findings indicate that stabilizing mutations can have higher fitness, and that fitness optima do not necessarily coincide with energy minima.","lang":"eng"}],"volume":14,"publication":"Journal of the Royal Society Interface","type":"journal_article","date_created":"2018-12-11T11:50:01Z","tmp":{"short":"CC BY (4.0)","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"related_material":{"record":[{"status":"public","relation":"research_data","id":"9864"}]},"ddc":["570"],"file":[{"date_updated":"2019-01-18T09:14:02Z","date_created":"2019-01-18T09:14:02Z","content_type":"application/pdf","creator":"dernst","file_name":"2017_JRSI_Redondo.pdf","file_id":"5843","access_level":"open_access","success":1,"relation":"main_file","file_size":1092015}],"ec_funded":1,"title":"Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publisher":"Royal Society","year":"2017","_id":"1077","date_updated":"2026-08-12T14:08:11Z","publication_identifier":{"issn":["1742-5689"]},"citation":{"ista":"Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. 2017. Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. Journal of the Royal Society Interface. 14(126), 20160139.","mla":"Fernandes Redondo, Rodrigo A., et al. “Evolutionary Interplay between Structure, Energy and Epistasis in the Coat Protein of the ΦX174 Phage Family.” <i>Journal of the Royal Society Interface</i>, vol. 14, no. 126, 20160139, Royal Society, 2017, doi:<a href=\"https://doi.org/10.1098/rsif.2016.0139\">10.1098/rsif.2016.0139</a>.","short":"R.A. Fernandes Redondo, H. de Vladar, T. Włodarski, J.P. Bollback, Journal of the Royal Society Interface 14 (2017).","ieee":"R. A. Fernandes Redondo, H. de Vladar, T. Włodarski, and J. P. Bollback, “Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family,” <i>Journal of the Royal Society Interface</i>, vol. 14, no. 126. Royal Society, 2017.","apa":"Fernandes Redondo, R. A., de Vladar, H., Włodarski, T., &#38; Bollback, J. P. (2017). Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. <i>Journal of the Royal Society Interface</i>. Royal Society. <a href=\"https://doi.org/10.1098/rsif.2016.0139\">https://doi.org/10.1098/rsif.2016.0139</a>","chicago":"Fernandes Redondo, Rodrigo A, Harold de Vladar, Tomasz Włodarski, and Jonathan P Bollback. “Evolutionary Interplay between Structure, Energy and Epistasis in the Coat Protein of the ΦX174 Phage Family.” <i>Journal of the Royal Society Interface</i>. Royal Society, 2017. <a href=\"https://doi.org/10.1098/rsif.2016.0139\">https://doi.org/10.1098/rsif.2016.0139</a>.","ama":"Fernandes Redondo RA, de Vladar H, Włodarski T, Bollback JP. Evolutionary interplay between structure, energy and epistasis in the coat protein of the ϕX174 phage family. <i>Journal of the Royal Society Interface</i>. 2017;14(126). doi:<a href=\"https://doi.org/10.1098/rsif.2016.0139\">10.1098/rsif.2016.0139</a>"},"status":"public","quality_controlled":"1","oa_version":"Published Version","department":[{"_id":"NiBa"},{"_id":"JoBo"}],"oa":1,"date_published":"2017-01-04T00:00:00Z","publist_id":"6303","project":[{"_id":"25B07788-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Limits to selection in biology and in evolutionary computation","grant_number":"250152"},{"name":"Selective Barriers to Horizontal Gene Transfer","call_identifier":"H2020","_id":"2578D616-B435-11E9-9278-68D0E5697425","grant_number":"648440"}],"external_id":{"isi":["000393380400001"]},"intvolume":"        14","isi":1,"author":[{"id":"409D5C96-F248-11E8-B48F-1D18A9856A87","first_name":"Rodrigo A","last_name":"Fernandes Redondo","full_name":"Fernandes Redondo, Rodrigo A","orcid":"0000-0002-5837-2793"},{"id":"2A181218-F248-11E8-B48F-1D18A9856A87","first_name":"Harold","orcid":"0000-0002-5985-7653","full_name":"Vladar, Harold","last_name":"Vladar"},{"first_name":"Tomasz","full_name":"Włodarski, Tomasz","last_name":"Włodarski"},{"id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87","first_name":"Jonathan P","last_name":"Bollback","full_name":"Bollback, Jonathan P","orcid":"0000-0002-4624-4612"}],"month":"01","file_date_updated":"2019-01-18T09:14:02Z","doi":"10.1098/rsif.2016.0139","issue":"126","has_accepted_license":"1","day":"04","scopus_import":"1","language":[{"iso":"eng"}],"article_processing_charge":"Yes (in subscription journal)"}]