@article{21295, abstract = {Depending on the type of flow, the transition to turbulence can take one of two forms: either turbulence arises from a sequence of instabilities or from the spatial proliferation of transiently chaotic domains, a process analogous to directed percolation. The former scenario is commonly referred to as a supercritical transition and frequently encountered in flows destabilized by body forces, whereas the latter subcritical transition is common in shear flows. Both cases are inherently continuous in a sense that the transformation from ordered laminar to fully turbulent fluid motion is only accomplished gradually with flow speed. Here we show that these established transition types do not account for the more general setting of shear flows subject to body forces. The combination of the two continuous scenarios leads to the attenuation of spatial coupling; with increasing forcing amplitude, the transition becomes increasingly sharp and eventually discontinuous. We argue that the suppression of laminar–turbulent coexistence and the approach towards a discontinuous phase transition potentially apply to a broad range of situations including flows subject to, for example, buoyancy, centrifugal or electromagnetic forces.}, author = {Yang, Bowen and Zhuang, Yi and Yalniz, Gökhan and Vasudevan, Mukund and Marensi, Elena and Hof, Björn}, issn = {1745-2481}, journal = {Nature Physics}, publisher = {Springer Nature}, title = {{Discontinuous transition to shear flow turbulence}}, doi = {10.1038/s41567-025-03166-3}, year = {2026}, } @article{21721, abstract = {Swimming bacteria move through a fluid by actuating their moving body parts. They are force-free and can be described as hydrodynamic force dipoles: pushers or pullers. This modelling description is broadly used in biological physics and active matter research, and it has successfully predicted, for example, the superfluid behaviour of suspensions of pushers or the bend instability and emergence of turbulent flows in active nematics. However, this description accounts only for the translational motion of the swimming body and neglects the effects of hydrodynamic torque dipoles, which are relevant to bacteria with rotary motor-driven flagella, such as swimming Escherichia coli. Here we show that the torque dipole of confined swimming E. coli can power the persistent rotation of symmetric discs. The torque dipole leads to a traction force on the discs, an additive mechanism that is both contactless and independent of the orientation of the bacteria. Our results indicate that the torque dipole of swimming E. coli is notable in confined geometries, which is relevant to bacterial transport through porous materials, biofilms and the development of chiral fluids.}, author = {Grober, Daniel B and Dhar, Tanumoy and Saintillan, David and Palacci, Jérémie A}, issn = {1745-2481}, journal = {Nature Physics}, publisher = {Springer Nature}, title = {{The hydrodynamic torque dipole from rotary bacterial flagella powers symmetric discs}}, doi = {10.1038/s41567-026-03189-4}, year = {2026}, } @article{21015, abstract = {Early embryo geometry is one of the most invariant species-specific traits, yet its role in ensuring developmental reproducibility and robustness remains underexplored. Here we show that in zebrafish, the geometry of the fertilized egg—specifically its curvature and volume—serves as a critical initial condition triggering a cascade of events that influence development. The embryo geometry guides patterned asymmetric cell divisions in the blastoderm, generating radial gradients of cell volume and nucleocytoplasmic ratio. These gradients generate mitotic phase waves, with the nucleocytoplasmic ratio determining individual cell cycle periods independently of other cells. We demonstrate that reducing cell autonomy reshapes these waves, emphasizing the instructive role of geometry-derived volume patterns in setting the intrinsic period of the cell cycle oscillator. In addition to organizing cell cycles, early embryo geometry spatially patterns zygotic genome activation at the midblastula transition, a key step in establishing embryonic autonomy. Disrupting the embryo shape alters the zygotic genome activation pattern and causes ectopic germ layer specification, underscoring the developmental significance of geometry. Together, our findings reveal a symmetry-breaking function of early embryo geometry in coordinating cell cycle and transcriptional patterning.}, author = {Mishra, Nikhil and Li, Yuting I and Hannezo, Edouard B and Heisenberg, Carl-Philipp J}, issn = {1745-2481}, journal = {Nature Physics}, pages = {139--150}, publisher = {Springer Nature}, title = {{Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo}}, doi = {10.1038/s41567-025-03122-1}, volume = {22}, year = {2026}, } @article{21006, abstract = {Modern experimental methods in programmable self-assembly make it possible to precisely design particle concentrations, shapes and interactions. However, more physical insight is needed before we can take full advantage of this vast design space to assemble nanostructures with complex form and function. Here we show how a substantial part of this design space can be quickly and comprehensively understood by identifying a class of thermodynamic constraints that act on it. These thermodynamic constraints form a high-dimensional convex polyhedron that determines which nanostructures can be assembled at high equilibrium yield and reveals limitations that govern the coexistence of structures. We validate our predictions through detailed, quantitative assembly experiments of nanoscale particles synthesized using DNA origami. Our results uncover physical relationships underpinning many-component programmable self-assembly in equilibrium and form the basis for robust inverse design, applicable to various systems from biological protein complexes to synthetic nanomachines.}, author = {Hübl, Maximilian and Videbæk, Thomas E. and Hayakawa, Daichi and Rogers, W. Benjamin and Goodrich, Carl Peter}, issn = {1745-2481}, journal = {Nature Physics}, publisher = {Springer Nature}, title = {{A polyhedral structure controls programmable self-assembly}}, doi = {10.1038/s41567-025-03120-3}, year = {2026}, } @article{20259, abstract = {Cell migration in narrow microenvironments occurs in numerous physiological processes. It involves successive cycles of confinement and release that drive important morphological changes. However, it remains unclear whether migrating cells can retain a memory of their past morphological states that could potentially facilitate their navigation through confined spaces. We demonstrate that local geometry governs a switch between two cell morphologies, thereby facilitating cell passage through long and narrow gaps. We combined cell migration assays on standardized microsystems with biophysical modelling and biochemical perturbations to show that migrating cells have a long-term memory of past confinement events. The morphological cell states correlate across transitions through actin cortex remodelling. These findings indicate that mechanical memory in migrating cells plays an active role in their migratory potential in confined environments.}, author = {Kalukula, Yohalie and Luciano, Marine and Simanov, Gleb and Charras, Guillaume and Brückner, David and Gabriele, Sylvain}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1451--1461}, publisher = {Springer Nature}, title = {{The actin cortex acts as a mechanical memory of morphology in confined migrating cells}}, doi = {10.1038/s41567-025-02980-z}, volume = {21}, year = {2025}, } @article{20431, abstract = {Haptotaxis is the process of directed cell migration along gradients of extracellular matrix density and is central to morphogenesis, immune responses and cancer invasion. It is commonly assumed that cells respond to these gradients by migrating directionally towards the regions of highest ligand density. In contrast with this view, here we show that cells exposed to micropatterned fibronectin gradients exhibit a wide range of complex trajectories, including directed haptotactic migration up the gradient but also linear oscillations and circles with extended periods of migration down the gradient. To explain this behaviour, we developed a biophysical model of haptotactic cell migration based on a coarse-grained molecular clutch model coupled to persistent stochastic polarity dynamics. Although initial haptotactic migration is explained by the differential friction at the front and back of the cell, the observed complex trajectories over longer timescales arise from the interplay between differential friction, persistence and physical confinement. Overall, our study reveals that confinement and persistence modulate the ability of cells to sense and respond to haptotactic cues and provides a framework for understanding how cells navigate complex environments.}, author = {Fortunato, Isabela Corina and Brückner, David and Grosser, Steffen and Nautiyal, Rohit and Rossetti, Leone and Bosch-Padrós, Miquel and Trebicka, Jonel and Roca-Cusachs, Pere and Sunyer, Raimon and Hannezo, Edouard B and Trepat, Xavier}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1638--1647}, publisher = {Springer Nature}, title = {{Single-cell migration along and against confined haptotactic gradients}}, doi = {10.1038/s41567-025-03015-3}, volume = {21}, year = {2025}, } @article{20432, abstract = {A rapidly increasing body of work reporting phenomena associated with lattice vibrations carrying angular momentum has led to the emergence of the field of chiral phonons. Some of these properties, such as the phonon magnetic moment, also occur in achiral phonons that are circularly or elliptically polarized, while the presence of chirality has additional implications for the types of interaction allowed between the phonons and light, electrons and other quasiparticles. In this Perspective we introduce a framework for classifying phonons with angular momentum, and provide illustrations of the different types using examples from the recent literature. Specifically, we suggest the term ‘axial phonon’ to encompass all phonons that carry angular momentum, real or pseudo, and reserve the term ‘chiral phonon’ for those phonons that break improper rotational symmetry. We hope that this scheme provides clarification on the matter of phonon chirality and will serve as a guide for future research.}, author = {Juraschek, Dominik M. and Geilhufe, R. Matthias and Zhu, Hanyu and Basini, Martina and Baum, Peter and Baydin, Andrey and Chaudhary, Swati and Fechner, Michael and Flebus, Benedetta and Grissonnanche, Gael and Kirilyuk, Andrei I. and Lemeshko, Mikhail and Maehrlein, Sebastian F. and Mignolet, Maxime and Murakami, Shuichi and Niu, Qian and Nowak, Ulrich and Romao, Carl P. and Rostami, Habib and Satoh, Takuya and Spaldin, Nicola A. and Ueda, Hiroki and Zhang, Lifa}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1532--1540}, publisher = {Springer Nature}, title = {{Chiral phonons}}, doi = {10.1038/s41567-025-03001-9}, volume = {21}, year = {2025}, } @article{19012, abstract = {False vacuum decay—the transition from a metastable quantum state to a true vacuum state—plays an important role in quantum field theory and non-equilibrium phenomena such as phase transitions and dynamical metastability. The non-perturbative nature of false vacuum decay and the limited experimental access to this process make it challenging to study, leaving several open questions regarding how true vacuum bubbles form, move and interact. Here we observe quantized bubble formation in real time, a key feature of false vacuum decay dynamics, using a quantum annealer with 5,564 superconducting flux qubits. We develop an effective model that captures both initial bubble creation and subsequent interactions, and remains accurate under dissipation. The annealer reveals coherent scaling laws in the driven many-body dynamics for more than 1,000 intrinsic qubit time units. This work provides a method for investigating false vacuum dynamics of large quantum systems in quantum annealers.}, author = {Vodeb, Jaka and Desaules, Jean-Yves Marc and Hallam, Andrew and Rava, Andrea and Humar, Gregor and Willsch, Dennis and Jin, Fengping and Willsch, Madita and Michielsen, Kristel and Papić, Zlatko}, issn = {1745-2481}, journal = {Nature Physics}, pages = {386--392}, publisher = {Springer Nature}, title = {{Stirring the false vacuum via interacting quantized bubbles on a 5,564-qubit quantum annealer}}, doi = {10.1038/s41567-024-02765-w}, volume = {21}, year = {2025}, } @article{19373, abstract = {Reproducible pattern and form generation during embryogenesis is poorly understood. Intestinal organoid morphogenesis involves a number of mechanochemical regulators such as cell-type-specific cytoskeletal forces and osmotically driven lumen volume changes. It is unclear how these forces are coordinated in time and space to ensure robust morphogenesis. Here we show how mechanosensitive feedback on cytoskeletal tension gives rise to morphological bistability in a minimal model of organoid morphogenesis. In the model, lumen volume changes can impact the epithelial shape via both direct mechanical and indirect mechanosensitive mechanisms. We find that both bulged and budded crypt states are possible and dependent on the history of volume changes. We test key modelling assumptions via biophysical and pharmacological experiments to demonstrate how bistability can explain experimental observations, such as the importance of the timing of lumen shrinkage and robustness of the final morphogenetic state to mechanical perturbations. This suggests that bistability arising from feedback between cellular tensions and fluid pressure could be a general mechanism that coordinates multicellular shape changes in developing systems.}, author = {Xue, Shi-lei and Yang, Qiutan and Liberali, Prisca and Hannezo, Edouard B}, issn = {1745-2481}, journal = {Nature Physics}, publisher = {Springer Nature}, title = {{Mechanochemical bistability of intestinal organoids enables robust morphogenesis}}, doi = {10.1038/s41567-025-02792-1}, volume = {21}, year = {2025}, } @article{19073, abstract = {The rapid development of superconducting quantum hardware is expected to run into substantial restrictions on scalability because error correction in a cryogenic environment has stringent input–output requirements. Classical data centres rely on fibre-optic interconnects to remove similar networking bottlenecks. In the same spirit, ultracold electro-optic links have been proposed and used to generate qubit control signals, or to replace cryogenic readout electronics. So far, these approaches have suffered from either low efficiency, low bandwidth or additional noise. Here we realize radio-over-fibre qubit readout at millikelvin temperatures. We use one device to simultaneously perform upconversion and downconversion between microwave and optical frequencies and so do not require any active or passive cryogenic microwave equipment. We demonstrate all-optical single-shot readout in a circulator-free readout scheme. Importantly, we do not observe any direct radiation impact on the qubit state, despite the absence of shielding elements. This compatibility between superconducting circuits and telecom-wavelength light is not only a prerequisite to establish modular quantum networks, but it is also relevant for multiplexed readout of superconducting photon detectors and classical superconducting logic.}, author = {Arnold, Georg M and Werner, Thomas and Sahu, Rishabh and Kapoor, Lucky and Qiu, Liu and Fink, Johannes M}, issn = {1745-2481}, journal = {Nature Physics}, publisher = {Springer Nature}, title = {{All-optical superconducting qubit readout}}, doi = {10.1038/s41567-024-02741-4}, volume = {21}, year = {2025}, } @article{18187, abstract = {Quasicrystals are ordered but not periodic, which makes them fascinating objects at the interface between order and disorder. Experiments with ultracold atoms zoom in on this interface by driving a quasicrystal and exploring its fractal properties.}, author = {Leonard, Julian}, issn = {1745-2481}, journal = {Nature Physics}, number = {3}, pages = {351--352}, publisher = {Springer Nature}, title = {{A kicked quasicrystal}}, doi = {10.1038/s41567-023-02357-0}, volume = {20}, year = {2024}, } @article{18919, abstract = {The integration of theory and experiment makes possible tracking the slow evolution of a photodoped Mott insulator to a distinct non-equilibrium metallic phase under the influence of electron-lattice coupling.}, author = {Baykusheva, Denitsa Rangelova}, issn = {1745-2481}, journal = {Nature Physics}, number = {5}, pages = {684--685}, publisher = {Springer Nature}, title = {{Through the slopes of a light-induced phase transition}}, doi = {10.1038/s41567-024-02401-7}, volume = {20}, year = {2024}, } @article{14846, abstract = {Contraction and flow of the actin cell cortex have emerged as a common principle by which cells reorganize their cytoplasm and take shape. However, how these cortical flows interact with adjacent cytoplasmic components, changing their form and localization, and how this affects cytoplasmic organization and cell shape remains unclear. Here we show that in ascidian oocytes, the cooperative activities of cortical actomyosin flows and deformation of the adjacent mitochondria-rich myoplasm drive oocyte cytoplasmic reorganization and shape changes following fertilization. We show that vegetal-directed cortical actomyosin flows, established upon oocyte fertilization, lead to both the accumulation of cortical actin at the vegetal pole of the zygote and compression and local buckling of the adjacent elastic solid-like myoplasm layer due to friction forces generated at their interface. Once cortical flows have ceased, the multiple myoplasm buckles resolve into one larger buckle, which again drives the formation of the contraction pole—a protuberance of the zygote’s vegetal pole where maternal mRNAs accumulate. Thus, our findings reveal a mechanism where cortical actomyosin network flows determine cytoplasmic reorganization and cell shape by deforming adjacent cytoplasmic components through friction forces.}, author = {Caballero Mancebo, Silvia and Shinde, Rushikesh and Bolger-Munro, Madison and Peruzzo, Matilda and Szep, Gregory and Steccari, Irene and Labrousse Arias, David and Zheden, Vanessa and Merrin, Jack and Callan-Jones, Andrew and Voituriez, Raphaël and Heisenberg, Carl-Philipp J}, issn = {1745-2481}, journal = {Nature Physics}, pages = {310--321}, publisher = {Springer Nature}, title = {{Friction forces determine cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization}}, doi = {10.1038/s41567-023-02302-1}, volume = {20}, year = {2024}, } @article{17128, abstract = {The onset of turbulence in pipe flow has defied detailed understanding ever since the first observations of the spatially heterogeneous nature of the transition. Recent theoretical studies and experiments in simpler, shear-driven flows suggest that the onset of turbulence is a directed-percolation non-equilibrium phase transition, but whether these findings are generic and also apply to open or pressure-driven flows is unknown. In pipe flow, the extremely long time scales near the transition make direct observations of critical behaviour virtually impossible. Here we find a technical solution to that limitation and show that the universality class of the transition is directed percolation, from which a jammed phase of puffs emerges above the critical point. Our method is to experimentally characterize all pairwise interactions between localized patches of turbulence puffs and use these interactions as input for renormalization group and computer simulations of minimal models that extrapolate to long length and time scales. The strong interactions in the jamming regime enable us to explicitly measure the turbulent fraction and confirm model predictions. Our work shows that directed-percolation scaling applies beyond simple closed shear flows and underscores how statistical mechanics can lead to profound, quantitative and predictive insights on turbulent flows and their phases.}, author = {Lemoult, Grégoire M and Vasudevan, Mukund and Shih, Hong Yan and Linga, Gaute and Mathiesen, Joachim and Goldenfeld, Nigel and Hof, Björn}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1339--1345}, publisher = {Springer Nature}, title = {{Directed percolation and puff jamming near the transition to pipe turbulence}}, doi = {10.1038/s41567-024-02513-0}, volume = {20}, year = {2024}, } @article{17269, abstract = {The directed migration of epithelial cell collectives through coordinated movements plays a crucial role in various physiological processes and is increasingly understood at the level of large confluent monolayers. However, numerous processes rely on the migration of small groups of polarized epithelial clusters in complex environments, and their responses to external geometries remain poorly understood. To address this, we cultivate primary epithelial keratocyte tissues on adhesive microstripes to create autonomous epithelial clusters with well-defined geometries. We show that their migration efficiency is strongly influenced by the contact geometry and the orientation of cell–cell contacts with respect to the direction of migration. A combination of velocity and polarity alignment with contact regulation of locomotion in an active matter model captures quantitatively the experimental data. Furthermore, we predict that this combination of rules enables efficient navigation in complex geometries, which we confirm experimentally. Altogether, our findings provide a conceptual framework for extracting the interaction rules of active systems from their interaction with physical boundaries, as well as design principles for collective navigation in complex microenvironments.}, author = {Vercruysse, Eléonore and Brückner, David and Gómez-González, Manuel and Remson, Alexandre and Luciano, Marine and Kalukula, Yohalie and Rossetti, Leone and Trepat, Xavier and Hannezo, Edouard B and Gabriele, Sylvain}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1492--1500}, publisher = {Springer Nature}, title = {{Geometry-driven migration efficiency of autonomous epithelial cell clusters}}, doi = {10.1038/s41567-024-02532-x}, volume = {20}, year = {2024}, } @article{17460, abstract = {Filaments in the cell commonly treadmill. Driven by energy consumption, they grow on one end while shrinking on the other, causing filaments to appear motile even though individual proteins remain static. This process is characteristic of cytoskeletal filaments and leads to collective filament self-organization. Here we show that treadmilling drives filament nematic ordering by dissolving misaligned filaments. Taking the bacterial FtsZ protein involved in cell division as an example, we show that this mechanism aligns FtsZ filaments in vitro and drives the organization of the division ring in living Bacillus subtilis cells. We find that ordering via local dissolution also allows the system to quickly respond to chemical and geometrical biases in the cell, enabling us to quantitatively explain the ring formation dynamics in vivo. Beyond FtsZ and other cytoskeletal filaments, our study identifies a mechanism for self-organization via constant birth and death of energy-consuming filaments.}, author = {Vanhille-Campos, Christian Eduardo and Whitley, Kevin D. and Radler, Philipp and Loose, Martin and Holden, Séamus and Šarić, Anđela}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1670--1678}, publisher = {Springer Nature}, title = {{Self-organization of mortal filaments and its role in bacterial division ring formation}}, doi = {10.1038/s41567-024-02597-8}, volume = {20}, year = {2024}, } @article{13971, abstract = {When in equilibrium, thermal forces agitate molecules, which then diffuse, collide and bind to form materials. However, the space of accessible structures in which micron-scale particles can be organized by thermal forces is limited, owing to the slow dynamics and metastable states. Active agents in a passive fluid generate forces and flows, forming a bath with active fluctuations. Two unanswered questions are whether those active agents can drive the assembly of passive components into unconventional states and which material properties they will exhibit. Here we show that passive, sticky beads immersed in a bath of swimming Escherichia coli bacteria aggregate into unconventional clusters and gels that are controlled by the activity of the bath. We observe a slow but persistent rotation of the aggregates that originates in the chirality of the E. coli flagella and directs aggregation into structures that are not accessible thermally. We elucidate the aggregation mechanism with a numerical model of spinning, sticky beads and reproduce quantitatively the experimental results. We show that internal activity controls the phase diagram and the structure of the aggregates. Overall, our results highlight the promising role of active baths in designing the structural and mechanical properties of materials with unconventional phases.}, author = {Grober, Daniel and Palaia, Ivan and Ucar, Mehmet C and Hannezo, Edouard B and Šarić, Anđela and Palacci, Jérémie A}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1680--1688}, publisher = {Springer Nature}, title = {{Unconventional colloidal aggregation in chiral bacterial baths}}, doi = {10.1038/s41567-023-02136-x}, volume = {19}, year = {2023}, } @article{18190, abstract = {Strongly correlated systems can exhibit unexpected phenomena when brought in a state far from equilibrium. An example is many-body localization, which prevents generic interacting systems from reaching thermal equilibrium even at long times1,2. The stability of the many-body localized phase has been predicted to be hindered by the presence of small thermal inclusions that act as a bath, leading to the delocalization of the entire system through an avalanche propagation mechanism3,4,5,6,7,8. Here we study the dynamics of a thermal inclusion of variable size when it is coupled to a many-body localized system. We find evidence for accelerated transport of thermal inclusion into the localized region. We monitor how the avalanche spreads through the localized system and thermalizes it site by site by measuring the site-resolved entropy over time. Furthermore, we isolate the strongly correlated bath-induced dynamics with multipoint correlations between the bath and the system. Our results have implications on the robustness of many-body localized systems and their critical behaviour.}, author = {Leonard, Julian and Kim, Sooshin and Rispoli, Matthew and Lukin, Alexander and Schittko, Robert and Kwan, Joyce and Demler, Eugene and Sels, Dries and Greiner, Markus}, issn = {1745-2481}, journal = {Nature Physics}, number = {4}, pages = {481--485}, publisher = {Springer Nature}, title = {{Probing the onset of quantum avalanches in a many-body localized system}}, doi = {10.1038/s41567-022-01887-3}, volume = {19}, year = {2023}, } @article{13118, abstract = {Under high pressures and temperatures, molecular systems with substantial polarization charges, such as ammonia and water, are predicted to form superionic phases and dense fluid states with dissociating molecules and high electrical conductivity. This behaviour potentially plays a role in explaining the origin of the multipolar magnetic fields of Uranus and Neptune, whose mantles are thought to result from a mixture of H2O, NH3 and CH4 ices. Determining the stability domain, melting curve and electrical conductivity of these superionic phases is therefore crucial for modelling planetary interiors and dynamos. Here we report the melting curve of superionic ammonia up to 300 GPa from laser-driven shock compression of pre-compressed samples and atomistic calculations. We show that ammonia melts at lower temperatures than water above 100 GPa and that fluid ammonia’s electrical conductivity exceeds that of water at conditions predicted by hot, super-adiabatic models for Uranus and Neptune, and enhances the conductivity in their fluid water-rich dynamo layers.}, author = {Hernandez, J.-A. and Bethkenhagen, Mandy and Ninet, S. and French, M. and Benuzzi-Mounaix, A. and Datchi, F. and Guarguaglini, M. and Lefevre, F. and Occelli, F. and Redmer, R. and Vinci, T. and Ravasio, A.}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1280--1285}, publisher = {Springer Nature}, title = {{Melting curve of superionic ammonia at planetary interior conditions}}, doi = {10.1038/s41567-023-02074-8}, volume = {19}, year = {2023}, } @article{13314, abstract = {The emergence of large-scale order in self-organized systems relies on local interactions between individual components. During bacterial cell division, FtsZ—a prokaryotic homologue of the eukaryotic protein tubulin—polymerizes into treadmilling filaments that further organize into a cytoskeletal ring. In vitro, FtsZ filaments can form dynamic chiral assemblies. However, how the active and passive properties of individual filaments relate to these large-scale self-organized structures remains poorly understood. Here we connect single-filament properties with the mesoscopic scale by combining minimal active matter simulations and biochemical reconstitution experiments. We show that the density and flexibility of active chiral filaments define their global order. At intermediate densities, curved, flexible filaments organize into chiral rings and polar bands. An effectively nematic organization dominates for high densities and for straight, mutant filaments with increased rigidity. Our predicted phase diagram quantitatively captures these features, demonstrating how the flexibility, density and chirality of the active filaments affect their collective behaviour. Our findings shed light on the fundamental properties of active chiral matter and explain how treadmilling FtsZ filaments organize during bacterial cell division.}, author = {Dunajova, Zuzana and Prats Mateu, Batirtze and Radler, Philipp and Lim, Keesiang and Brandis, Dörte and Velicky, Philipp and Danzl, Johann G and Wong, Richard W. and Elgeti, Jens and Hannezo, Edouard B and Loose, Martin}, issn = {1745-2481}, journal = {Nature Physics}, pages = {1916--1926}, publisher = {Springer Nature}, title = {{Chiral and nematic phases of flexible active filaments}}, doi = {10.1038/s41567-023-02218-w}, volume = {19}, year = {2023}, }