---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21295'
abstract:
- lang: eng
text: 'Depending on the type of flow, the transition to turbulence can take one
of two forms: either turbulence arises from a sequence of instabilities or from
the spatial proliferation of transiently chaotic domains, a process analogous
to directed percolation. The former scenario is commonly referred to as a supercritical
transition and frequently encountered in flows destabilized by body forces, whereas
the latter subcritical transition is common in shear flows. Both cases are inherently
continuous in a sense that the transformation from ordered laminar to fully turbulent
fluid motion is only accomplished gradually with flow speed. Here we show that
these established transition types do not account for the more general setting
of shear flows subject to body forces. The combination of the two continuous scenarios
leads to the attenuation of spatial coupling; with increasing forcing amplitude,
the transition becomes increasingly sharp and eventually discontinuous. We argue
that the suppression of laminar–turbulent coexistence and the approach towards
a discontinuous phase transition potentially apply to a broad range of situations
including flows subject to, for example, buoyancy, centrifugal or electromagnetic
forces.'
acknowledgement: The work was supported by the Simons Foundation (grant number 662960,
to B.H.). Open access funding provided by Institute of Science and Technology (IST
Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Bowen
full_name: Yang, Bowen
id: 71b6ff4b-15b2-11ec-abd3-aef6b028cf7e
last_name: Yang
orcid: 0000-0002-4843-6853
- first_name: Yi
full_name: Zhuang, Yi
id: 3677B57C-F248-11E8-B48F-1D18A9856A87
last_name: Zhuang
- first_name: Gökhan
full_name: Yalniz, Gökhan
id: 66E74FA2-D8BF-11E9-8249-8DE2E5697425
last_name: Yalniz
orcid: 0000-0002-8490-9312
- first_name: Mukund
full_name: Vasudevan, Mukund
id: 3C5A959A-F248-11E8-B48F-1D18A9856A87
last_name: Vasudevan
- first_name: Elena
full_name: Marensi, Elena
id: 0BE7553A-1004-11EA-B805-18983DDC885E
last_name: Marensi
orcid: 0000-0001-7173-4923
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. Discontinuous transition
to shear flow turbulence. Nature Physics. 2026. doi:10.1038/s41567-025-03166-3
apa: Yang, B., Zhuang, Y., Yalniz, G., Vasudevan, M., Marensi, E., & Hof, B.
(2026). Discontinuous transition to shear flow turbulence. Nature Physics.
Springer Nature. https://doi.org/10.1038/s41567-025-03166-3
chicago: Yang, Bowen, Yi Zhuang, Gökhan Yalniz, Mukund Vasudevan, Elena Marensi,
and Björn Hof. “Discontinuous Transition to Shear Flow Turbulence.” Nature
Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-025-03166-3.
ieee: B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, and B. Hof, “Discontinuous
transition to shear flow turbulence,” Nature Physics. Springer Nature,
2026.
ista: Yang B, Zhuang Y, Yalniz G, Vasudevan M, Marensi E, Hof B. 2026. Discontinuous
transition to shear flow turbulence. Nature Physics.
mla: Yang, Bowen, et al. “Discontinuous Transition to Shear Flow Turbulence.” Nature
Physics, Springer Nature, 2026, doi:10.1038/s41567-025-03166-3.
short: B. Yang, Y. Zhuang, G. Yalniz, M. Vasudevan, E. Marensi, B. Hof, Nature Physics
(2026).
corr_author: '1'
date_created: 2026-02-17T11:38:41Z
date_published: 2026-02-17T00:00:00Z
date_updated: 2026-02-23T11:36:46Z
day: '17'
ddc:
- '532'
department:
- _id: GradSch
- _id: BjHo
doi: 10.1038/s41567-025-03166-3
external_id:
arxiv:
- '2311.11474'
has_accepted_license: '1'
language:
- iso: eng
month: '02'
oa_version: Published Version
project:
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
grant_number: '662960'
name: Revisiting the Turbulence Problem Using Statistical Mechanics
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Discontinuous transition to shear flow turbulence
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21721'
abstract:
- lang: eng
text: 'Swimming bacteria move through a fluid by actuating their moving body parts.
They are force-free and can be described as hydrodynamic force dipoles: pushers
or pullers. This modelling description is broadly used in biological physics and
active matter research, and it has successfully predicted, for example, the superfluid
behaviour of suspensions of pushers or the bend instability and emergence of turbulent
flows in active nematics. However, this description accounts only for the translational
motion of the swimming body and neglects the effects of hydrodynamic torque dipoles,
which are relevant to bacteria with rotary motor-driven flagella, such as swimming
Escherichia coli. Here we show that the torque dipole of confined swimming E.
coli can power the persistent rotation of symmetric discs. The torque dipole leads
to a traction force on the discs, an additive mechanism that is both contactless
and independent of the orientation of the bacteria. Our results indicate that
the torque dipole of swimming E. coli is notable in confined geometries, which
is relevant to bacterial transport through porous materials, biofilms and the
development of chiral fluids.'
acknowledged_ssus:
- _id: NanoFab
- _id: EM-Fac
acknowledgement: We thank E. Krasnopeeva for help with the bacterial culture, motility
and genetic engineering. We thank Q. Martinet for help with the experimental design,
F. Pertl for atomic force microscopy measurements and S. Hajek for the scanning
electron microscopy imaging. This project has received funding from the European
Research Council under the European Union’s Horizon Europe research and innovation
programme (VULCAN, 101086998). The views and opinions expressed are, however, those
of the authors only and do not necessarily reflect those of the European Union or
the European Research Council Executive Agency. Neither the European Union nor the
granting authority can be held responsible for them. J.P. thanks the Nanofabrication
and Electron Microscopy Shared Scientific Units of ISTA for support. Open access
funding provided by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Daniel B
full_name: Grober, Daniel B
id: c692f879-718d-11ee-81f0-da7caa79c783
last_name: Grober
- first_name: Tanumoy
full_name: Dhar, Tanumoy
last_name: Dhar
- first_name: David
full_name: Saintillan, David
last_name: Saintillan
- first_name: Jérémie A
full_name: Palacci, Jérémie A
id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
last_name: Palacci
orcid: 0000-0002-7253-9465
citation:
ama: Grober DB, Dhar T, Saintillan D, Palacci JA. The hydrodynamic torque dipole
from rotary bacterial flagella powers symmetric discs. Nature Physics.
2026. doi:10.1038/s41567-026-03189-4
apa: Grober, D. B., Dhar, T., Saintillan, D., & Palacci, J. A. (2026). The hydrodynamic
torque dipole from rotary bacterial flagella powers symmetric discs. Nature
Physics. Springer Nature. https://doi.org/10.1038/s41567-026-03189-4
chicago: Grober, Daniel B, Tanumoy Dhar, David Saintillan, and Jérémie A Palacci.
“The Hydrodynamic Torque Dipole from Rotary Bacterial Flagella Powers Symmetric
Discs.” Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-026-03189-4.
ieee: D. B. Grober, T. Dhar, D. Saintillan, and J. A. Palacci, “The hydrodynamic
torque dipole from rotary bacterial flagella powers symmetric discs,” Nature
Physics. Springer Nature, 2026.
ista: Grober DB, Dhar T, Saintillan D, Palacci JA. 2026. The hydrodynamic torque
dipole from rotary bacterial flagella powers symmetric discs. Nature Physics.
mla: Grober, Daniel B., et al. “The Hydrodynamic Torque Dipole from Rotary Bacterial
Flagella Powers Symmetric Discs.” Nature Physics, Springer Nature, 2026,
doi:10.1038/s41567-026-03189-4.
short: D.B. Grober, T. Dhar, D. Saintillan, J.A. Palacci, Nature Physics (2026).
corr_author: '1'
date_created: 2026-04-12T22:01:51Z
date_published: 2026-03-27T00:00:00Z
date_updated: 2026-04-16T06:20:23Z
day: '27'
ddc:
- '570'
department:
- _id: JePa
doi: 10.1038/s41567-026-03189-4
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41567-026-03189-4
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: bdac72da-d553-11ed-ba76-eae56e802b74
grant_number: '101086998'
name: 'VULCAN: matter, powered from within'
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The hydrodynamic torque dipole from rotary bacterial flagella powers symmetric
discs
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21015'
abstract:
- lang: eng
text: Early embryo geometry is one of the most invariant species-specific traits,
yet its role in ensuring developmental reproducibility and robustness remains
underexplored. Here we show that in zebrafish, the geometry of the fertilized
egg—specifically its curvature and volume—serves as a critical initial condition
triggering a cascade of events that influence development. The embryo geometry
guides patterned asymmetric cell divisions in the blastoderm, generating radial
gradients of cell volume and nucleocytoplasmic ratio. These gradients generate
mitotic phase waves, with the nucleocytoplasmic ratio determining individual cell
cycle periods independently of other cells. We demonstrate that reducing cell
autonomy reshapes these waves, emphasizing the instructive role of geometry-derived
volume patterns in setting the intrinsic period of the cell cycle oscillator.
In addition to organizing cell cycles, early embryo geometry spatially patterns
zygotic genome activation at the midblastula transition, a key step in establishing
embryonic autonomy. Disrupting the embryo shape alters the zygotic genome activation
pattern and causes ectopic germ layer specification, underscoring the developmental
significance of geometry. Together, our findings reveal a symmetry-breaking function
of early embryo geometry in coordinating cell cycle and transcriptional patterning.
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: ScienComp
- _id: LifeSc
acknowledgement: We thank N. Petridou (EMBL) for sharing results before publication.
N.M. was supported by funding from the European Union’s Horizon 2020 programme under
the Marie Skłodowska-Curie COFUND Actions ISTplus grant agreement number 754411.
Y.I.L. acknowledges funding from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement number 101034413.
The research was supported by funding to C.-P.H. from the NOMIS Foundation, Project
ID 1.844. We would like to thank past and present members of the Heisenberg and
Hannezo groups for discussions, particularly S. Shamipour, V. Doddihal, M. Jovic,
N. Hino, F. N. Arslan, R. Kobylinska and C. Camelo for feedback on the draft manuscript.
This research was supported by the Scientific Service Units (SSU) of Institute of
Science and Technology Austria through resources provided by the Aquatics Facility,
Imaging & Optics Facility (IOF), Scientific Computing (SciComp) facility and Lab
Support Facility (LSF). Open access funding provided by Institute of Science and
Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Nikhil
full_name: Mishra, Nikhil
id: C4D70E82-1081-11EA-B3ED-9A4C3DDC885E
last_name: Mishra
orcid: 0000-0002-6425-5788
- first_name: Yuting I
full_name: Li, Yuting I
id: ee7a5ca8-8b71-11ed-b662-b3341c05b7eb
last_name: Li
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. Geometry-driven asymmetric cell
divisions pattern cell cycles and zygotic genome activation in the zebrafish embryo.
Nature Physics. 2026;22:139-150. doi:10.1038/s41567-025-03122-1
apa: Mishra, N., Li, Y. I., Hannezo, E. B., & Heisenberg, C.-P. J. (2026). Geometry-driven
asymmetric cell divisions pattern cell cycles and zygotic genome activation in
the zebrafish embryo. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03122-1
chicago: Mishra, Nikhil, Yuting I Li, Edouard B Hannezo, and Carl-Philipp J Heisenberg.
“Geometry-Driven Asymmetric Cell Divisions Pattern Cell Cycles and Zygotic Genome
Activation in the Zebrafish Embryo.” Nature Physics. Springer Nature, 2026.
https://doi.org/10.1038/s41567-025-03122-1.
ieee: N. Mishra, Y. I. Li, E. B. Hannezo, and C.-P. J. Heisenberg, “Geometry-driven
asymmetric cell divisions pattern cell cycles and zygotic genome activation in
the zebrafish embryo,” Nature Physics, vol. 22. Springer Nature, pp. 139–150,
2026.
ista: Mishra N, Li YI, Hannezo EB, Heisenberg C-PJ. 2026. Geometry-driven asymmetric
cell divisions pattern cell cycles and zygotic genome activation in the zebrafish
embryo. Nature Physics. 22, 139–150.
mla: Mishra, Nikhil, et al. “Geometry-Driven Asymmetric Cell Divisions Pattern Cell
Cycles and Zygotic Genome Activation in the Zebrafish Embryo.” Nature Physics,
vol. 22, Springer Nature, 2026, pp. 139–50, doi:10.1038/s41567-025-03122-1.
short: N. Mishra, Y.I. Li, E.B. Hannezo, C.-P.J. Heisenberg, Nature Physics 22 (2026)
139–150.
corr_author: '1'
date_created: 2026-01-20T10:12:19Z
date_published: 2026-01-05T00:00:00Z
date_updated: 2026-04-28T12:55:30Z
day: '05'
ddc:
- '570'
department:
- _id: EdHa
- _id: CaHe
doi: 10.1038/s41567-025-03122-1
ec_funded: 1
external_id:
oaworkid:
- W7118187193
file:
- access_level: open_access
checksum: 0ab7ac2fbcb61a364dba57152db64ed7
content_type: application/pdf
creator: dernst
date_created: 2026-01-21T08:21:11Z
date_updated: 2026-01-21T08:21:11Z
file_id: '21026'
file_name: 2026_NaturePhysics_Mishra.pdf
file_size: 7335694
relation: main_file
success: 1
file_date_updated: 2026-01-21T08:21:11Z
has_accepted_license: '1'
intvolume: ' 22'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
oaworkid: 1
page: 139-150
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: 917c023a-16d5-11f0-9cad-eb5cafc52090
name: Cytoplasmic self-organization into cell-like compartments as a common guiding
principle in early animal development
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
issnl:
- ' 1745-2473'
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: research_data
url: https://ista.ac.at/en/news/geometry-shapes-life/
scopus_import: '1'
status: public
title: Geometry-driven asymmetric cell divisions pattern cell cycles and zygotic genome
activation in the zebrafish embryo
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 22
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21006'
abstract:
- lang: eng
text: Modern experimental methods in programmable self-assembly make it possible
to precisely design particle concentrations, shapes and interactions. However,
more physical insight is needed before we can take full advantage of this vast
design space to assemble nanostructures with complex form and function. Here we
show how a substantial part of this design space can be quickly and comprehensively
understood by identifying a class of thermodynamic constraints that act on it.
These thermodynamic constraints form a high-dimensional convex polyhedron that
determines which nanostructures can be assembled at high equilibrium yield and
reveals limitations that govern the coexistence of structures. We validate our
predictions through detailed, quantitative assembly experiments of nanoscale particles
synthesized using DNA origami. Our results uncover physical relationships underpinning
many-component programmable self-assembly in equilibrium and form the basis for
robust inverse design, applicable to various systems from biological protein complexes
to synthetic nanomachines.
acknowledgement: We thank B. Isaac and A. Tiano for their technical support with the
electron microscopy and S. Waitukaitis for helpful comments on the manuscript. The
TEM images were prepared and imaged at the Brandeis Electron Microscopy facility.
This work was supported by the Gesellschaft für Forschungsförderung Niederösterreich
under project FTI23-G-011 (M.C.H. and C.P.G.), the Brandeis University Materials
Research Science and Engineering Center (MRSEC) under grant number NSF DMR-2011846
(T.E.V., D.H. and W.B.R.) and the Smith Family Foundation (W.B.R.). Open access
funding provided by Institute of Science and Technology (IST Austria).
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Maximilian
full_name: Hübl, Maximilian
id: 5eb8629e-15b2-11ec-abd3-e6f3e5e01f32
last_name: Hübl
- first_name: Thomas E.
full_name: Videbæk, Thomas E.
last_name: Videbæk
- first_name: Daichi
full_name: Hayakawa, Daichi
last_name: Hayakawa
- first_name: W. Benjamin
full_name: Rogers, W. Benjamin
last_name: Rogers
- first_name: Carl Peter
full_name: Goodrich, Carl Peter
id: EB352CD2-F68A-11E9-89C5-A432E6697425
last_name: Goodrich
orcid: 0000-0002-1307-5074
citation:
ama: Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. A polyhedral structure
controls programmable self-assembly. Nature Physics. 2026. doi:10.1038/s41567-025-03120-3
apa: Hübl, M., Videbæk, T. E., Hayakawa, D., Rogers, W. B., & Goodrich, C. P.
(2026). A polyhedral structure controls programmable self-assembly. Nature
Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03120-3
chicago: Hübl, Maximilian, Thomas E. Videbæk, Daichi Hayakawa, W. Benjamin Rogers,
and Carl Peter Goodrich. “A Polyhedral Structure Controls Programmable Self-Assembly.”
Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-025-03120-3.
ieee: M. Hübl, T. E. Videbæk, D. Hayakawa, W. B. Rogers, and C. P. Goodrich, “A
polyhedral structure controls programmable self-assembly,” Nature Physics.
Springer Nature, 2026.
ista: Hübl M, Videbæk TE, Hayakawa D, Rogers WB, Goodrich CP. 2026. A polyhedral
structure controls programmable self-assembly. Nature Physics.
mla: Hübl, Maximilian, et al. “A Polyhedral Structure Controls Programmable Self-Assembly.”
Nature Physics, Springer Nature, 2026, doi:10.1038/s41567-025-03120-3.
short: M. Hübl, T.E. Videbæk, D. Hayakawa, W.B. Rogers, C.P. Goodrich, Nature Physics
(2026).
corr_author: '1'
date_created: 2026-01-20T10:02:19Z
date_published: 2026-01-08T00:00:00Z
date_updated: 2026-04-28T11:56:45Z
day: '08'
ddc:
- '570'
- '540'
department:
- _id: CaGo
- _id: GradSch
doi: 10.1038/s41567-025-03120-3
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41567-025-03120-3
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 8dd93da8-16d5-11f0-9cad-d2c70200d9a5
grant_number: FTI23-G-011
name: Dynamically reconfigurable self-assembly with triangular DNA-origami bricks
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/behind-natures-blueprints/
scopus_import: '1'
status: public
title: A polyhedral structure controls programmable self-assembly
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
year: '2026'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '21849'
abstract:
- lang: eng
text: The development of complex tissues relies on the precise assignment of cell
identity. At the molecular scale, this process depends on the deposition of epigenetic
modifications—such as methylation—that are regulated by complex biochemical networks
and occur at specific regions on the DNA and chromatin. Here we show that despite
the complexity of epigenetic regulation, dynamical scaling and self-similarity
of DNA methylation marks emerge in embryonic development. Drawing on single-cell
multi-omics experiments, super-resolution microscopy and statistical physics,
we demonstrate that these phenomena originate in dynamical feedback between DNA
methylation and the formation of nanoscale dynamic chromatin aggregates. These
nanoscale processes lead to genome-wide increase in DNA methylation marks following
a power law and self-similar correlation functions. Using this framework, we identify
methylation patterns that precede gene expression changes in embryonic symmetry
breaking. Our work identifies linear sequencing measurements as a laboratory to
study mesoscopic biophysical processes in vivo.
acknowledgement: We thank all members of the W.R. and S.R. laboratories, F. Piazza,
B. D. Simons, and F. Jülicher for helpful discussions. We thank M. Ciarchi for providing
annotations for the chromatin compartments. S.R. is a member of the Center for Nano
Science (CeNS). This project has received funding from the European Research Council
(ERC) under the European Union’s Horizon 2020 research and innovation programme
(grant agreement number 950349). Research in W.R.’s laboratory was supported by
the Biotechnology and Biological Sciences Research Council (BB/K010867/1), Wellcome
(095645/Z/11/Z) and the European Research Council (ERC) under the European Union’s
Horizon 2020 research and innovation programme (EpiCell lineage 882798). F.O. received
funding from the European Union’s Horizon 2020 research and innovation programme
under the Marie Skłodowska-Curie grant agreement number 101034413. Open access funding
provided by Max Planck Society.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Fabrizio
full_name: Olmeda, Fabrizio
id: 69dbf5fb-8a76-11ed-866b-fb486d8b5689
last_name: Olmeda
- first_name: Tim
full_name: Lohoff, Tim
last_name: Lohoff
- first_name: Ioannis
full_name: Kafetzopoulos, Ioannis
last_name: Kafetzopoulos
- first_name: Stephen J.
full_name: Clark, Stephen J.
last_name: Clark
- first_name: Laura
full_name: Benson, Laura
last_name: Benson
- first_name: Fatima
full_name: Santos, Fatima
last_name: Santos
- first_name: Felix
full_name: Krueger, Felix
last_name: Krueger
- first_name: Simon
full_name: Walker, Simon
last_name: Walker
- first_name: Wolf
full_name: Reik, Wolf
last_name: Reik
- first_name: Steffen
full_name: Rulands, Steffen
last_name: Rulands
citation:
ama: Olmeda F, Lohoff T, Kafetzopoulos I, et al. Scaling and self-similarity in
the formation of the embryonic epigenome. Nature Physics. 2026. doi:10.1038/s41567-026-03263-x
apa: Olmeda, F., Lohoff, T., Kafetzopoulos, I., Clark, S. J., Benson, L., Santos,
F., … Rulands, S. (2026). Scaling and self-similarity in the formation of the
embryonic epigenome. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-026-03263-x
chicago: Olmeda, Fabrizio, Tim Lohoff, Ioannis Kafetzopoulos, Stephen J. Clark,
Laura Benson, Fatima Santos, Felix Krueger, Simon Walker, Wolf Reik, and Steffen
Rulands. “Scaling and Self-Similarity in the Formation of the Embryonic Epigenome.”
Nature Physics. Springer Nature, 2026. https://doi.org/10.1038/s41567-026-03263-x.
ieee: F. Olmeda et al., “Scaling and self-similarity in the formation of
the embryonic epigenome,” Nature Physics. Springer Nature, 2026.
ista: Olmeda F, Lohoff T, Kafetzopoulos I, Clark SJ, Benson L, Santos F, Krueger
F, Walker S, Reik W, Rulands S. 2026. Scaling and self-similarity in the formation
of the embryonic epigenome. Nature Physics.
mla: Olmeda, Fabrizio, et al. “Scaling and Self-Similarity in the Formation of the
Embryonic Epigenome.” Nature Physics, Springer Nature, 2026, doi:10.1038/s41567-026-03263-x.
short: F. Olmeda, T. Lohoff, I. Kafetzopoulos, S.J. Clark, L. Benson, F. Santos,
F. Krueger, S. Walker, W. Reik, S. Rulands, Nature Physics (2026).
date_created: 2026-05-10T22:02:16Z
date_published: 2026-04-29T00:00:00Z
date_updated: 2026-05-11T06:22:47Z
day: '29'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41567-026-03263-x
ec_funded: 1
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1038/s41567-026-03263-x
month: '04'
oa: 1
oa_version: Published Version
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Scaling and self-similarity in the formation of the embryonic epigenome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2026'
...
---
OA_type: closed access
_id: '20259'
abstract:
- lang: eng
text: Cell migration in narrow microenvironments occurs in numerous physiological
processes. It involves successive cycles of confinement and release that drive
important morphological changes. However, it remains unclear whether migrating
cells can retain a memory of their past morphological states that could potentially
facilitate their navigation through confined spaces. We demonstrate that local
geometry governs a switch between two cell morphologies, thereby facilitating
cell passage through long and narrow gaps. We combined cell migration assays on
standardized microsystems with biophysical modelling and biochemical perturbations
to show that migrating cells have a long-term memory of past confinement events.
The morphological cell states correlate across transitions through actin cortex
remodelling. These findings indicate that mechanical memory in migrating cells
plays an active role in their migratory potential in confined environments.
acknowledgement: We are grateful to members of S.G.’s laboratory for feedback and
suggestions. We thank E. Hannezo, J. O. Rädler, M. Piel, O. du Roure and J. Heuvingh
for inspiring discussions. Y.K. and S.G. acknowledge J. B. Braquenier from Nikon
Instruments Belux and the Nikon BioImaging Lab in Leiden (the Netherlands) for their
support with the Nikon Spatial Array Confocal enhanced-resolution confocal microscopy.
We thank D. S. Herrador and M. Balland for their help in improving the microprinting
method. D.B.B. was supported by the NOMIS Foundation as a NOMIS Fellow and by an
EMBO Postdoctoral Fellowship (ALTF 343-2022). Y.K., M.L. and S.G. acknowledge funding
from the University of Mons (FEDER Prostem Research Project no. 1510614, Wallonia
DG06), the F.R.S.-FNRS (Epiforce Project no. T.0092.21, Cellsqueezer Project no.
J.0061.23 and Optopattern Project no. U.NO26.22) and the Interreg projects ANTIRESI
and MICROPLAITE, which are financially supported by Interreg France-Wallonie-Vlaanderen
(Fonds Européen de Développement Régional). Y.K. and M.L. are financially supported
by F.R.S.-FNRS as FRIA Grantee FNRS and Postdoctoral Fellow (Chargé de Recherches),
respectively. Y.K. and S.G. acknowledge le Fonds pour la Recherche Médicale dans
le Hainaut (FRMH). G.C. was supported by a grant from the Biotechnology and Biological
Sciences Research Council (grant no. BB/V007483/1).
article_processing_charge: No
article_type: original
author:
- first_name: Yohalie
full_name: Kalukula, Yohalie
last_name: Kalukula
- first_name: Marine
full_name: Luciano, Marine
last_name: Luciano
- first_name: Gleb
full_name: Simanov, Gleb
last_name: Simanov
- first_name: Guillaume
full_name: Charras, Guillaume
last_name: Charras
- first_name: David
full_name: Brückner, David
id: e1e86031-6537-11eb-953a-f7ab92be508d
last_name: Brückner
orcid: 0000-0001-7205-2975
- first_name: Sylvain
full_name: Gabriele, Sylvain
last_name: Gabriele
citation:
ama: Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. The actin
cortex acts as a mechanical memory of morphology in confined migrating cells.
Nature Physics. 2025;21:1451-1461. doi:10.1038/s41567-025-02980-z
apa: Kalukula, Y., Luciano, M., Simanov, G., Charras, G., Brückner, D., & Gabriele,
S. (2025). The actin cortex acts as a mechanical memory of morphology in confined
migrating cells. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-02980-z
chicago: Kalukula, Yohalie, Marine Luciano, Gleb Simanov, Guillaume Charras, David
Brückner, and Sylvain Gabriele. “The Actin Cortex Acts as a Mechanical Memory
of Morphology in Confined Migrating Cells.” Nature Physics. Springer Nature,
2025. https://doi.org/10.1038/s41567-025-02980-z.
ieee: Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, and S. Gabriele,
“The actin cortex acts as a mechanical memory of morphology in confined migrating
cells,” Nature Physics, vol. 21. Springer Nature, pp. 1451–1461, 2025.
ista: Kalukula Y, Luciano M, Simanov G, Charras G, Brückner D, Gabriele S. 2025.
The actin cortex acts as a mechanical memory of morphology in confined migrating
cells. Nature Physics. 21, 1451–1461.
mla: Kalukula, Yohalie, et al. “The Actin Cortex Acts as a Mechanical Memory of
Morphology in Confined Migrating Cells.” Nature Physics, vol. 21, Springer
Nature, 2025, pp. 1451–61, doi:10.1038/s41567-025-02980-z.
short: Y. Kalukula, M. Luciano, G. Simanov, G. Charras, D. Brückner, S. Gabriele,
Nature Physics 21 (2025) 1451–1461.
corr_author: '1'
date_created: 2025-08-31T22:01:33Z
date_published: 2025-09-01T00:00:00Z
date_updated: 2025-12-30T09:34:11Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-025-02980-z
external_id:
isi:
- '001556019400001'
intvolume: ' 21'
isi: 1
language:
- iso: eng
month: '09'
oa_version: None
page: 1451-1461
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
grant_number: ALTF 343-2022
name: A mechano-chemical theory for stem cell fate decisions in organoid development
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The actin cortex acts as a mechanical memory of morphology in confined migrating
cells
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2025'
...
---
OA_place: repository
OA_type: green
_id: '20431'
abstract:
- lang: eng
text: Haptotaxis is the process of directed cell migration along gradients of extracellular
matrix density and is central to morphogenesis, immune responses and cancer invasion.
It is commonly assumed that cells respond to these gradients by migrating directionally
towards the regions of highest ligand density. In contrast with this view, here
we show that cells exposed to micropatterned fibronectin gradients exhibit a wide
range of complex trajectories, including directed haptotactic migration up the
gradient but also linear oscillations and circles with extended periods of migration
down the gradient. To explain this behaviour, we developed a biophysical model
of haptotactic cell migration based on a coarse-grained molecular clutch model
coupled to persistent stochastic polarity dynamics. Although initial haptotactic
migration is explained by the differential friction at the front and back of the
cell, the observed complex trajectories over longer timescales arise from the
interplay between differential friction, persistence and physical confinement.
Overall, our study reveals that confinement and persistence modulate the ability
of cells to sense and respond to haptotactic cues and provides a framework for
understanding how cells navigate complex environments.
acknowledgement: We thank all the members of our groups for discussions and support.
We thank A. Menéndez, S. Usieto, M. Purciolas and E. Coderch for technical assistance.
We thank G. Charras (London Centre for Nanotechnology, UK) and M. Sheetz (Columbia
University, USA) for sharing cells used in this work. We thank J. Ivaska (University
of Turku, Finland) for sharing integrin α5-GFP DNA plasmid. We thank P. Guillamat
for technical advice and A. Labernardie for providing the microfluidic channels.
We thank M. Gómez-González for sharing the 2D traction microscopy algorithm. Finally,
we thank P. Guillamat, J. Abenza, G. Ceada, L. Faure, E. Dalaka, M. Matejčić, A.
Beedle, I. Granero, O. Baguer, A. Albajar and N. Chahare for discussions. This paper
was funded by the Generalitat de Catalunya (Grant Nos. AGAUR SGR-2017-01602 to X.T.
and 2021 SGR 00523 to R.S. and the CERCA Programme and ICREA Academia awards to
P.R.-C.), the Spanish Ministry for Science and Innovation MICCINN/FEDER (Grant Nos.
PID2021-128635NB-I00, MCIN/AEI/10.13039/501100011033 and ERDF-EU A way of making
Europe to X.T., PID2021-128674OB-I00 and CNS2022-135533 to R.S. and PID2019-110298GB-I00
to P.R.-C.), the European Research Council (Grant Nos. 101097753 to P.R.-C. and
Adv-883739 to X.T.), Fundació la Marató de TV3 (Project Award 201903-30-31-32 to
X.T.), the European Commission (Grant No. H2020-FETPROACT-01-2016-731957 to P.R.-C.
and X.T.) and La Caixa Foundation (Grant No. LCF/PR/HR20/52400004 to P.R.-C. and
X.T.). R.S. is a Serra-Hunter fellow. D.B.B. was supported by the NOMIS foundation
as a NOMIS fellow, by the European Molecular Biology Organization (Postdoctoral
Fellowship ALTF 343-2022) and by the Austrian Academy of Sciences through an APART-MINT
Fellowship. I.C.F. acknowledges support from the European Foundation for the Study
of Chronic Liver Failure. IBEC is recipient of a Severo Ochoa Award of Excellence
from MINECO.
article_processing_charge: No
article_type: original
author:
- first_name: Isabela Corina
full_name: Fortunato, Isabela Corina
last_name: Fortunato
- first_name: David
full_name: Brückner, David
id: e1e86031-6537-11eb-953a-f7ab92be508d
last_name: Brückner
orcid: 0000-0001-7205-2975
- first_name: Steffen
full_name: Grosser, Steffen
last_name: Grosser
- first_name: Rohit
full_name: Nautiyal, Rohit
last_name: Nautiyal
- first_name: Leone
full_name: Rossetti, Leone
last_name: Rossetti
- first_name: Miquel
full_name: Bosch-Padrós, Miquel
last_name: Bosch-Padrós
- first_name: Jonel
full_name: Trebicka, Jonel
last_name: Trebicka
- first_name: Pere
full_name: Roca-Cusachs, Pere
last_name: Roca-Cusachs
- first_name: Raimon
full_name: Sunyer, Raimon
last_name: Sunyer
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Xavier
full_name: Trepat, Xavier
last_name: Trepat
citation:
ama: Fortunato IC, Brückner D, Grosser S, et al. Single-cell migration along and
against confined haptotactic gradients. Nature Physics. 2025;21:1638-1647.
doi:10.1038/s41567-025-03015-3
apa: Fortunato, I. C., Brückner, D., Grosser, S., Nautiyal, R., Rossetti, L., Bosch-Padrós,
M., … Trepat, X. (2025). Single-cell migration along and against confined haptotactic
gradients. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03015-3
chicago: Fortunato, Isabela Corina, David Brückner, Steffen Grosser, Rohit Nautiyal,
Leone Rossetti, Miquel Bosch-Padrós, Jonel Trebicka, et al. “Single-Cell Migration
along and against Confined Haptotactic Gradients.” Nature Physics. Springer
Nature, 2025. https://doi.org/10.1038/s41567-025-03015-3.
ieee: I. C. Fortunato et al., “Single-cell migration along and against confined
haptotactic gradients,” Nature Physics, vol. 21. Springer Nature, pp. 1638–1647,
2025.
ista: Fortunato IC, Brückner D, Grosser S, Nautiyal R, Rossetti L, Bosch-Padrós
M, Trebicka J, Roca-Cusachs P, Sunyer R, Hannezo EB, Trepat X. 2025. Single-cell
migration along and against confined haptotactic gradients. Nature Physics. 21,
1638–1647.
mla: Fortunato, Isabela Corina, et al. “Single-Cell Migration along and against
Confined Haptotactic Gradients.” Nature Physics, vol. 21, Springer Nature,
2025, pp. 1638–47, doi:10.1038/s41567-025-03015-3.
short: I.C. Fortunato, D. Brückner, S. Grosser, R. Nautiyal, L. Rossetti, M. Bosch-Padrós,
J. Trebicka, P. Roca-Cusachs, R. Sunyer, E.B. Hannezo, X. Trepat, Nature Physics
21 (2025) 1638–1647.
corr_author: '1'
date_created: 2025-10-05T22:01:36Z
date_published: 2025-10-01T00:00:00Z
date_updated: 2026-01-05T14:26:28Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-025-03015-3
external_id:
isi:
- '001581659900001'
intvolume: ' 21'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2024.12.02.626413
month: '10'
oa: 1
oa_version: Preprint
page: 1638-1647
project:
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
grant_number: ALTF 343-2022
name: A mechano-chemical theory for stem cell fate decisions in organoid development
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Single-cell migration along and against confined haptotactic gradients
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2025'
...
---
OA_type: closed access
_id: '20432'
abstract:
- lang: eng
text: A rapidly increasing body of work reporting phenomena associated with lattice
vibrations carrying angular momentum has led to the emergence of the field of
chiral phonons. Some of these properties, such as the phonon magnetic moment,
also occur in achiral phonons that are circularly or elliptically polarized, while
the presence of chirality has additional implications for the types of interaction
allowed between the phonons and light, electrons and other quasiparticles. In
this Perspective we introduce a framework for classifying phonons with angular
momentum, and provide illustrations of the different types using examples from
the recent literature. Specifically, we suggest the term ‘axial phonon’ to encompass
all phonons that carry angular momentum, real or pseudo, and reserve the term
‘chiral phonon’ for those phonons that break improper rotational symmetry. We
hope that this scheme provides clarification on the matter of phonon chirality
and will serve as a guide for future research.
acknowledgement: We thank A. V. Balatsky, E. Bousquet, A. Disa, S. Kamba, L. Klebl,
R. Merlin, A. Srivastava, A. Stroppa, M. Udina, P. Wong and D. Xiao for valuable
discussions. M.B. acknowledges support from SNSF Ambizione project number PZ00P2_216089.
P.B. and U.N. acknowledge funding from the Deutsche Forschungsgemeinschaft (grant
number 541503763). B.F. acknowledges support from the National Science Foundation
under grant number NSF DMR-2144086. G.G. acknowledges support from STeP2 number
ANR-22-EXES-0013, QuantExt number ANR-23-CE30-0001-01, Audace CEA number ANR-24-RRII-0004
and the École Polytechnique foundation. A.I.K. acknowledges the Nederlandse Organisatie
voor Wetenschappelijk Onderzoek (NWO-I) for their financial contribution, including
the support of the HFML-FELIX Laboratory. D.M.J. acknowledges support from Tel Aviv
University and ERC Starting Grant CHIRALPHONONICS grant number 101166037. S.F.M.
acknowledges funding from the Deutsche Forschungsgemeinschaft (grant number 469405347).
C.P.R. and N.A.S. were supported by ETH Zurich and by the European Union and Horizon
2020, grant agreement numbers 810451 and 101030352. R.M.G. acknowledges support
from the Swedish Research Council (VR starting grant number 2022-03350), the Olle
Engkvist Foundation (grant number 229-0443), the Royal Physiographic Society in
Lund (Horisont), the Knut and Alice Wallenberg Foundation (grant number 2023.0087)
and Chalmers University of Technology via the Department of Physics and the Areas
of Advance Nano and Materials Science. Q.N. is supported by the National Natural
Science Foundation of China (grant number 12234017) and the National Key Research
and Development Program of China (grant number 2023YFA1406300). H.R. acknowledges
funding from the Engineering and Physical Sciences Research Council (grant number
UKRI122) and Royal Society (grant number IES\R2\242309). T.S. acknowledges support
from MEXT X-NICS (grant number JPJ011438), NINS OML Project (grant number OML012301)
and JST CREST (grant number JPMJCR24R5). H.Z. acknowledges support from the Welch
Foundation (grant number C-2128) and the National Science Foundation (grant number
DMR-2240106). We acknowledge support from the Centre Européen de Calcul Atomique
et Moléculaire (CECAM) in connection to organizing the workshop "Chiral Phonons
in Quantum Materials", held in 2023, where the idea for this paper emerged.
article_processing_charge: No
article_type: original
author:
- first_name: Dominik M.
full_name: Juraschek, Dominik M.
last_name: Juraschek
- first_name: R. Matthias
full_name: Geilhufe, R. Matthias
last_name: Geilhufe
- first_name: Hanyu
full_name: Zhu, Hanyu
last_name: Zhu
- first_name: Martina
full_name: Basini, Martina
last_name: Basini
- first_name: Peter
full_name: Baum, Peter
last_name: Baum
- first_name: Andrey
full_name: Baydin, Andrey
last_name: Baydin
- first_name: Swati
full_name: Chaudhary, Swati
last_name: Chaudhary
- first_name: Michael
full_name: Fechner, Michael
last_name: Fechner
- first_name: Benedetta
full_name: Flebus, Benedetta
last_name: Flebus
- first_name: Gael
full_name: Grissonnanche, Gael
last_name: Grissonnanche
- first_name: Andrei I.
full_name: Kirilyuk, Andrei I.
last_name: Kirilyuk
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
- first_name: Sebastian F.
full_name: Maehrlein, Sebastian F.
last_name: Maehrlein
- first_name: Maxime
full_name: Mignolet, Maxime
last_name: Mignolet
- first_name: Shuichi
full_name: Murakami, Shuichi
last_name: Murakami
- first_name: Qian
full_name: Niu, Qian
last_name: Niu
- first_name: Ulrich
full_name: Nowak, Ulrich
last_name: Nowak
- first_name: Carl P.
full_name: Romao, Carl P.
last_name: Romao
- first_name: Habib
full_name: Rostami, Habib
last_name: Rostami
- first_name: Takuya
full_name: Satoh, Takuya
last_name: Satoh
- first_name: Nicola A.
full_name: Spaldin, Nicola A.
last_name: Spaldin
- first_name: Hiroki
full_name: Ueda, Hiroki
last_name: Ueda
- first_name: Lifa
full_name: Zhang, Lifa
last_name: Zhang
citation:
ama: Juraschek DM, Geilhufe RM, Zhu H, et al. Chiral phonons. Nature Physics.
2025;21:1532-1540. doi:10.1038/s41567-025-03001-9
apa: Juraschek, D. M., Geilhufe, R. M., Zhu, H., Basini, M., Baum, P., Baydin, A.,
… Zhang, L. (2025). Chiral phonons. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-025-03001-9
chicago: Juraschek, Dominik M., R. Matthias Geilhufe, Hanyu Zhu, Martina Basini,
Peter Baum, Andrey Baydin, Swati Chaudhary, et al. “Chiral Phonons.” Nature
Physics. Springer Nature, 2025. https://doi.org/10.1038/s41567-025-03001-9.
ieee: D. M. Juraschek et al., “Chiral phonons,” Nature Physics, vol.
21. Springer Nature, pp. 1532–1540, 2025.
ista: Juraschek DM, Geilhufe RM, Zhu H, Basini M, Baum P, Baydin A, Chaudhary S,
Fechner M, Flebus B, Grissonnanche G, Kirilyuk AI, Lemeshko M, Maehrlein SF, Mignolet
M, Murakami S, Niu Q, Nowak U, Romao CP, Rostami H, Satoh T, Spaldin NA, Ueda
H, Zhang L. 2025. Chiral phonons. Nature Physics. 21, 1532–1540.
mla: Juraschek, Dominik M., et al. “Chiral Phonons.” Nature Physics, vol.
21, Springer Nature, 2025, pp. 1532–40, doi:10.1038/s41567-025-03001-9.
short: D.M. Juraschek, R.M. Geilhufe, H. Zhu, M. Basini, P. Baum, A. Baydin, S.
Chaudhary, M. Fechner, B. Flebus, G. Grissonnanche, A.I. Kirilyuk, M. Lemeshko,
S.F. Maehrlein, M. Mignolet, S. Murakami, Q. Niu, U. Nowak, C.P. Romao, H. Rostami,
T. Satoh, N.A. Spaldin, H. Ueda, L. Zhang, Nature Physics 21 (2025) 1532–1540.
date_created: 2025-10-05T22:01:37Z
date_published: 2025-10-01T00:00:00Z
date_updated: 2026-01-05T13:25:59Z
day: '01'
department:
- _id: MiLe
doi: 10.1038/s41567-025-03001-9
external_id:
isi:
- '001575765100001'
intvolume: ' 21'
isi: 1
language:
- iso: eng
month: '10'
oa_version: None
page: 1532-1540
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Chiral phonons
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19012'
abstract:
- lang: eng
text: False vacuum decay—the transition from a metastable quantum state to a true
vacuum state—plays an important role in quantum field theory and non-equilibrium
phenomena such as phase transitions and dynamical metastability. The non-perturbative
nature of false vacuum decay and the limited experimental access to this process
make it challenging to study, leaving several open questions regarding how true
vacuum bubbles form, move and interact. Here we observe quantized bubble formation
in real time, a key feature of false vacuum decay dynamics, using a quantum annealer
with 5,564 superconducting flux qubits. We develop an effective model that captures
both initial bubble creation and subsequent interactions, and remains accurate
under dissipation. The annealer reveals coherent scaling laws in the driven many-body
dynamics for more than 1,000 intrinsic qubit time units. This work provides a
method for investigating false vacuum dynamics of large quantum systems in quantum
annealers.
acknowledgement: J.V., D.W. and M.W. acknowledge support from the project Jülich UNified
Infrastructure for Quantum computing (JUNIQ) that has received funding from the
German Federal Ministry of Education and Research (BMBF) and the Ministry of Culture
and Science of the State of North Rhine-Westphalia. A.R. acknowledges support from
the project HPCQS (101018180) of the European High-Performance Computing Joint Undertaking
(EuroHPC JU). J.-Y.D., A.H. and Z.P. acknowledge support from the Leverhulme Trust
Research Leadership Award RL-2019-015 and EPSRC grant nos. EP/R513258/1 and EP/W026848/1.
J.-Y.D. acknowledges support from the European Union’s Horizon 2020 research and
innovation programme under the Marie Skłodowska-Curie grant agreement no.101034413.
This research was supported in part by grant no. NSF PHY-2309135 to the Kavli Institute
for Theoretical Physics (KITP). Computational portions of this research work were
carried out on ARC3 and ARC4, part of the high-performance computing facilities
at the University of Leeds. G.H. acknowledges financial support from ARIS, P1-0040
Nonequilibrium Quantum System Dynamics. We gratefully acknowledge the Jülich Supercomputing
Centre (https://www.fz-juelich.de/en/ias/jsc) for funding this project by providing
computing time on the D-Wave Advantage System JUPSI through JUNIQ. We acknowledge
helpful theoretical discussions with G. Lagnese and the quantum-simulation-related
discussions with D-Wave’s experimental team, particularly A. MacDonald, G. Poulin-Lamarre,
A. Daian and A. Berkley. We also thank V. Goliber and A. Mason for patiently organizing
and mediating the corresponding meetings that enabled the discussions with D-Wave’s
team. J.V., A.R., D.W., F.J., M.W. and K.M. gratefully acknowledge the Gauss Centre
for Supercomputing e.V. (www.gauss-centre.eu) for funding this project by providing
computing time on the GCS Supercomputer JUWELS at Jülich Supercomputing Centre (JSC).
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Jaka
full_name: Vodeb, Jaka
last_name: Vodeb
- first_name: Jean-Yves Marc
full_name: Desaules, Jean-Yves Marc
id: 6c292945-a610-11ed-9eec-c3be1ad62a80
last_name: Desaules
orcid: 0000-0002-3749-6375
- first_name: Andrew
full_name: Hallam, Andrew
last_name: Hallam
- first_name: Andrea
full_name: Rava, Andrea
last_name: Rava
- first_name: Gregor
full_name: Humar, Gregor
last_name: Humar
- first_name: Dennis
full_name: Willsch, Dennis
last_name: Willsch
- first_name: Fengping
full_name: Jin, Fengping
last_name: Jin
- first_name: Madita
full_name: Willsch, Madita
last_name: Willsch
- first_name: Kristel
full_name: Michielsen, Kristel
last_name: Michielsen
- first_name: Zlatko
full_name: Papić, Zlatko
last_name: Papić
citation:
ama: Vodeb J, Desaules J-YM, Hallam A, et al. Stirring the false vacuum via interacting
quantized bubbles on a 5,564-qubit quantum annealer. Nature Physics. 2025;21:386-392.
doi:10.1038/s41567-024-02765-w
apa: Vodeb, J., Desaules, J.-Y. M., Hallam, A., Rava, A., Humar, G., Willsch, D.,
… Papić, Z. (2025). Stirring the false vacuum via interacting quantized bubbles
on a 5,564-qubit quantum annealer. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-024-02765-w
chicago: Vodeb, Jaka, Jean-Yves Marc Desaules, Andrew Hallam, Andrea Rava, Gregor
Humar, Dennis Willsch, Fengping Jin, Madita Willsch, Kristel Michielsen, and Zlatko
Papić. “Stirring the False Vacuum via Interacting Quantized Bubbles on a 5,564-Qubit
Quantum Annealer.” Nature Physics. Springer Nature, 2025. https://doi.org/10.1038/s41567-024-02765-w.
ieee: J. Vodeb et al., “Stirring the false vacuum via interacting quantized
bubbles on a 5,564-qubit quantum annealer,” Nature Physics, vol. 21. Springer
Nature, pp. 386–392, 2025.
ista: Vodeb J, Desaules J-YM, Hallam A, Rava A, Humar G, Willsch D, Jin F, Willsch
M, Michielsen K, Papić Z. 2025. Stirring the false vacuum via interacting quantized
bubbles on a 5,564-qubit quantum annealer. Nature Physics. 21, 386–392.
mla: Vodeb, Jaka, et al. “Stirring the False Vacuum via Interacting Quantized Bubbles
on a 5,564-Qubit Quantum Annealer.” Nature Physics, vol. 21, Springer Nature,
2025, pp. 386–92, doi:10.1038/s41567-024-02765-w.
short: J. Vodeb, J.-Y.M. Desaules, A. Hallam, A. Rava, G. Humar, D. Willsch, F.
Jin, M. Willsch, K. Michielsen, Z. Papić, Nature Physics 21 (2025) 386–392.
corr_author: '1'
date_created: 2025-02-06T10:07:13Z
date_published: 2025-03-01T00:00:00Z
date_updated: 2025-09-30T10:29:15Z
day: '01'
ddc:
- '530'
department:
- _id: MaSe
doi: 10.1038/s41567-024-02765-w
ec_funded: 1
external_id:
arxiv:
- '2406.14718'
isi:
- '001412684400001'
pmid:
- '40093970'
file:
- access_level: open_access
checksum: b005ccf7448fee29c187cbc9b1944893
content_type: application/pdf
creator: dernst
date_created: 2025-08-05T11:56:53Z
date_updated: 2025-08-05T11:56:53Z
file_id: '20127'
file_name: 2025_NaturePhysics_Vodeb.pdf
file_size: 2252107
relation: main_file
success: 1
file_date_updated: 2025-08-05T11:56:53Z
has_accepted_license: '1'
intvolume: ' 21'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 386-392
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/dancing-bubbles-model-a-cosmic-disaster/
scopus_import: '1'
status: public
title: Stirring the false vacuum via interacting quantized bubbles on a 5,564-qubit
quantum annealer
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 21
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
PlanS_conform: '1'
_id: '19373'
abstract:
- lang: eng
text: Reproducible pattern and form generation during embryogenesis is poorly understood.
Intestinal organoid morphogenesis involves a number of mechanochemical regulators
such as cell-type-specific cytoskeletal forces and osmotically driven lumen volume
changes. It is unclear how these forces are coordinated in time and space to ensure
robust morphogenesis. Here we show how mechanosensitive feedback on cytoskeletal
tension gives rise to morphological bistability in a minimal model of organoid
morphogenesis. In the model, lumen volume changes can impact the epithelial shape
via both direct mechanical and indirect mechanosensitive mechanisms. We find that
both bulged and budded crypt states are possible and dependent on the history
of volume changes. We test key modelling assumptions via biophysical and pharmacological
experiments to demonstrate how bistability can explain experimental observations,
such as the importance of the timing of lumen shrinkage and robustness of the
final morphogenetic state to mechanical perturbations. This suggests that bistability
arising from feedback between cellular tensions and fluid pressure could be a
general mechanism that coordinates multicellular shape changes in developing systems.
acknowledgement: We thank all members of the Hannezo and Liberali groups for fruitful
discussions, as well as C. Schwayer, G. Quintas, L. Capolupo, D. Bruckner and D.
Pinheiro for reading the manuscript. We also thank Y. Wu and X. Wu from the Yang
group for performing experiments in the last rounds of revision and the So group
at the National Institute of Biological Sciences, Beijing, for helping with the
light-sheet time-lapse experiments. This work received funding from the European
Research Council (ERC) under the European Union’s Horizon 2020 research and innovation
programme via grant agreement no. 758617 (to P.L.), Swiss National Foundation (SNF)
(no. POOP3_157531 to P.L.), the ERC under the European Union’s Horizon 2020 research
and innovation programme under grant agreement no. 851288 (to E.H.) and the Austrian
Science Fund (FWF) (no. P 31639 to E.H.). This work was supported by the National
Natural Science Foundation of China via grant no.3247060387 (to Q.Y.) and the Strategic
Priority Research Program of the Chinese Academy of Sciences (no. XDB0820000 to
Q.Y.) . Open access funding provided by Institute of Science and Technology (IST
Austria).
article_number: '078104'
article_processing_charge: Yes (via OA deal)
article_type: original
arxiv: 1
author:
- first_name: Shi-lei
full_name: Xue, Shi-lei
id: 31D2C804-F248-11E8-B48F-1D18A9856A87
last_name: Xue
- first_name: Qiutan
full_name: Yang, Qiutan
last_name: Yang
- first_name: Prisca
full_name: Liberali, Prisca
last_name: Liberali
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
citation:
ama: Xue S, Yang Q, Liberali P, Hannezo EB. Mechanochemical bistability of intestinal
organoids enables robust morphogenesis. Nature Physics. 2025;21. doi:10.1038/s41567-025-02792-1
apa: Xue, S., Yang, Q., Liberali, P., & Hannezo, E. B. (2025). Mechanochemical
bistability of intestinal organoids enables robust morphogenesis. Nature Physics.
Springer Nature. https://doi.org/10.1038/s41567-025-02792-1
chicago: Xue, Shi-lei, Qiutan Yang, Prisca Liberali, and Edouard B Hannezo. “Mechanochemical
Bistability of Intestinal Organoids Enables Robust Morphogenesis.” Nature Physics.
Springer Nature, 2025. https://doi.org/10.1038/s41567-025-02792-1.
ieee: S. Xue, Q. Yang, P. Liberali, and E. B. Hannezo, “Mechanochemical bistability
of intestinal organoids enables robust morphogenesis,” Nature Physics,
vol. 21. Springer Nature, 2025.
ista: Xue S, Yang Q, Liberali P, Hannezo EB. 2025. Mechanochemical bistability of
intestinal organoids enables robust morphogenesis. Nature Physics. 21, 078104.
mla: Xue, Shi-lei, et al. “Mechanochemical Bistability of Intestinal Organoids Enables
Robust Morphogenesis.” Nature Physics, vol. 21, 078104, Springer Nature,
2025, doi:10.1038/s41567-025-02792-1.
short: S. Xue, Q. Yang, P. Liberali, E.B. Hannezo, Nature Physics 21 (2025).
corr_author: '1'
date_created: 2025-03-09T23:01:28Z
date_published: 2025-02-28T00:00:00Z
date_updated: 2025-09-30T10:47:36Z
day: '28'
ddc:
- '530'
department:
- _id: EdHa
doi: 10.1038/s41567-025-02792-1
ec_funded: 1
external_id:
arxiv:
- '2403.19900'
isi:
- '001434072800001'
pmid:
- '40248571'
file:
- access_level: open_access
checksum: fb5e59be145b95f9851d3d7c9dbb85e6
content_type: application/pdf
creator: dernst
date_created: 2025-08-05T12:12:03Z
date_updated: 2025-08-05T12:12:03Z
file_id: '20129'
file_name: 2025_NaturePhysics_Xue.pdf
file_size: 16302436
relation: main_file
success: 1
file_date_updated: 2025-08-05T12:12:03Z
has_accepted_license: '1'
intvolume: ' 21'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 268294B6-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P31639
name: Active mechano-chemical description of the cell cytoskeleton
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Mechanochemical bistability of intestinal organoids enables robust morphogenesis
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 21
year: '2025'
...
---
OA_place: publisher
OA_type: hybrid
_id: '19073'
abstract:
- lang: eng
text: The rapid development of superconducting quantum hardware is expected to run
into substantial restrictions on scalability because error correction in a cryogenic
environment has stringent input–output requirements. Classical data centres rely
on fibre-optic interconnects to remove similar networking bottlenecks. In the
same spirit, ultracold electro-optic links have been proposed and used to generate
qubit control signals, or to replace cryogenic readout electronics. So far, these
approaches have suffered from either low efficiency, low bandwidth or additional
noise. Here we realize radio-over-fibre qubit readout at millikelvin temperatures.
We use one device to simultaneously perform upconversion and downconversion between
microwave and optical frequencies and so do not require any active or passive
cryogenic microwave equipment. We demonstrate all-optical single-shot readout
in a circulator-free readout scheme. Importantly, we do not observe any direct
radiation impact on the qubit state, despite the absence of shielding elements.
This compatibility between superconducting circuits and telecom-wavelength light
is not only a prerequisite to establish modular quantum networks, but it is also
relevant for multiplexed readout of superconducting photon detectors and classical
superconducting logic.
acknowledgement: We thank F. Hassani and M. Zemlicka for assistance with qubit design
and high-power readout, respectively, and P. Winkel and I. Pop at Karlsruhe Institute
of Technology for providing the JPA. This work was supported by the European Research
Council under grant nos. 758053 (ERC StG QUNNECT) and 101089099 (ERC CoG cQEO),
and the European Union’s Horizon 2020 research and innovation program under grant
no. 899354 (FETopen SuperQuLAN). This research was funded in whole, or in part,
by the Austrian Science Fund (FWF) DOI 10.55776/F71. L.Q. acknowledges generous
support from the ISTFELLOW programme and G.A. is the recipient of a DOC fellowship
of the Austrian Academy of Sciences at IST Austria. Open access funding provided
by Institute of Science and Technology (IST Austria).
article_number: '9470'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Georg M
full_name: Arnold, Georg M
id: 3770C838-F248-11E8-B48F-1D18A9856A87
last_name: Arnold
orcid: 0000-0003-1397-7876
- first_name: Thomas
full_name: Werner, Thomas
id: 1fcd8497-dba3-11ea-a45e-c6fbd715f7c7
last_name: Werner
orcid: 0009-0001-2346-5236
- first_name: Rishabh
full_name: Sahu, Rishabh
id: 47D26E34-F248-11E8-B48F-1D18A9856A87
last_name: Sahu
orcid: 0000-0001-6264-2162
- first_name: Lucky
full_name: Kapoor, Lucky
id: 84b9700b-15b2-11ec-abd3-831089e67615
last_name: Kapoor
orcid: 0000-0001-8319-2148
- first_name: Liu
full_name: Qiu, Liu
id: 45e99c0d-1eb1-11eb-9b96-ed8ab2983cac
last_name: Qiu
orcid: 0000-0003-4345-4267
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
citation:
ama: Arnold GM, Werner T, Sahu R, Kapoor L, Qiu L, Fink JM. All-optical superconducting
qubit readout. Nature Physics. 2025;21. doi:10.1038/s41567-024-02741-4
apa: Arnold, G. M., Werner, T., Sahu, R., Kapoor, L., Qiu, L., & Fink, J. M.
(2025). All-optical superconducting qubit readout. Nature Physics. Springer
Nature. https://doi.org/10.1038/s41567-024-02741-4
chicago: Arnold, Georg M, Thomas Werner, Rishabh Sahu, Lucky Kapoor, Liu Qiu, and
Johannes M Fink. “All-Optical Superconducting Qubit Readout.” Nature Physics.
Springer Nature, 2025. https://doi.org/10.1038/s41567-024-02741-4.
ieee: G. M. Arnold, T. Werner, R. Sahu, L. Kapoor, L. Qiu, and J. M. Fink, “All-optical
superconducting qubit readout,” Nature Physics, vol. 21. Springer Nature,
2025.
ista: Arnold GM, Werner T, Sahu R, Kapoor L, Qiu L, Fink JM. 2025. All-optical superconducting
qubit readout. Nature Physics. 21, 9470.
mla: Arnold, Georg M., et al. “All-Optical Superconducting Qubit Readout.” Nature
Physics, vol. 21, 9470, Springer Nature, 2025, doi:10.1038/s41567-024-02741-4.
short: G.M. Arnold, T. Werner, R. Sahu, L. Kapoor, L. Qiu, J.M. Fink, Nature Physics
21 (2025).
corr_author: '1'
date_created: 2025-02-23T23:01:57Z
date_published: 2025-03-01T00:00:00Z
date_updated: 2026-05-20T13:35:42Z
day: '01'
ddc:
- '530'
department:
- _id: JoFi
doi: 10.1038/s41567-024-02741-4
ec_funded: 1
external_id:
isi:
- '001417760400001'
pmid:
- '40093969'
file:
- access_level: open_access
checksum: ab7469aca9e2e068eb78e5c5c1efaf7d
content_type: application/pdf
creator: dernst
date_created: 2025-04-16T08:09:43Z
date_updated: 2025-04-16T08:09:43Z
file_id: '19572'
file_name: 2025_NaturePhysics_Arnold.pdf
file_size: 3396595
relation: main_file
success: 1
file_date_updated: 2025-04-16T08:09:43Z
has_accepted_license: '1'
intvolume: ' 21'
isi: 1
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: bdadfa0d-d553-11ed-ba76-fb85edbd456a
grant_number: '101089099'
name: 'Cavity Quantum Electro Optics: Microwave photonics with nonclassical states'
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
call_identifier: H2020
grant_number: '899354'
name: Quantum Local Area Networks with Superconducting Qubits
- _id: 2671EB66-B435-11E9-9278-68D0E5697425
name: Coherent on-chip conversion of superconducting qubit signals from microwaves
to optical frequencies
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
grant_number: F07105
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/when-qubits-learn-the-language-of-fiberoptics/
record:
- id: '18953'
relation: earlier_version
status: public
- id: '21863'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: All-optical superconducting qubit readout
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 21
year: '2025'
...
---
_id: '18187'
abstract:
- lang: eng
text: Quasicrystals are ordered but not periodic, which makes them fascinating objects
at the interface between order and disorder. Experiments with ultracold atoms
zoom in on this interface by driving a quasicrystal and exploring its fractal
properties.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Julian
full_name: Leonard, Julian
id: b75b3f45-7995-11ef-9bfd-9a9cd02c3577
last_name: Leonard
orcid: 0000-0003-3696-6870
citation:
ama: Leonard J. A kicked quasicrystal. Nature Physics. 2024;20(3):351-352.
doi:10.1038/s41567-023-02357-0
apa: Leonard, J. (2024). A kicked quasicrystal. Nature Physics. Springer
Nature. https://doi.org/10.1038/s41567-023-02357-0
chicago: Leonard, Julian. “A Kicked Quasicrystal.” Nature Physics. Springer
Nature, 2024. https://doi.org/10.1038/s41567-023-02357-0.
ieee: J. Leonard, “A kicked quasicrystal,” Nature Physics, vol. 20, no. 3.
Springer Nature, pp. 351–352, 2024.
ista: Leonard J. 2024. A kicked quasicrystal. Nature Physics. 20(3), 351–352.
mla: Leonard, Julian. “A Kicked Quasicrystal.” Nature Physics, vol. 20, no.
3, Springer Nature, 2024, pp. 351–52, doi:10.1038/s41567-023-02357-0.
short: J. Leonard, Nature Physics 20 (2024) 351–352.
date_created: 2024-10-07T11:45:17Z
date_published: 2024-01-19T00:00:00Z
date_updated: 2024-10-14T07:54:20Z
day: '19'
doi: 10.1038/s41567-023-02357-0
extern: '1'
intvolume: ' 20'
issue: '3'
language:
- iso: eng
month: '01'
oa_version: None
page: 351-352
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: A kicked quasicrystal
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 20
year: '2024'
...
---
OA_type: closed access
_id: '18919'
abstract:
- lang: eng
text: The integration of theory and experiment makes possible tracking the slow
evolution of a photodoped Mott insulator to a distinct non-equilibrium metallic
phase under the influence of electron-lattice coupling.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Denitsa Rangelova
full_name: Baykusheva, Denitsa Rangelova
id: 71b4d059-2a03-11ee-914d-dfa3beed6530
last_name: Baykusheva
citation:
ama: Baykusheva DR. Through the slopes of a light-induced phase transition. Nature
Physics. 2024;20(5):684-685. doi:10.1038/s41567-024-02401-7
apa: Baykusheva, D. R. (2024). Through the slopes of a light-induced phase transition.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-024-02401-7
chicago: Baykusheva, Denitsa Rangelova. “Through the Slopes of a Light-Induced Phase
Transition.” Nature Physics. Springer Nature, 2024. https://doi.org/10.1038/s41567-024-02401-7.
ieee: D. R. Baykusheva, “Through the slopes of a light-induced phase transition,”
Nature Physics, vol. 20, no. 5. Springer Nature, pp. 684–685, 2024.
ista: Baykusheva DR. 2024. Through the slopes of a light-induced phase transition.
Nature Physics. 20(5), 684–685.
mla: Baykusheva, Denitsa Rangelova. “Through the Slopes of a Light-Induced Phase
Transition.” Nature Physics, vol. 20, no. 5, Springer Nature, 2024, pp.
684–85, doi:10.1038/s41567-024-02401-7.
short: D.R. Baykusheva, Nature Physics 20 (2024) 684–685.
corr_author: '1'
date_created: 2025-01-27T14:29:20Z
date_published: 2024-05-01T00:00:00Z
date_updated: 2025-09-09T12:08:10Z
day: '01'
department:
- _id: DeBa
doi: 10.1038/s41567-024-02401-7
external_id:
isi:
- '001162208200002'
intvolume: ' 20'
isi: 1
issue: '5'
language:
- iso: eng
month: '05'
oa_version: None
page: 684-685
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Through the slopes of a light-induced phase transition
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 20
year: '2024'
...
---
_id: '14846'
abstract:
- lang: eng
text: Contraction and flow of the actin cell cortex have emerged as a common principle
by which cells reorganize their cytoplasm and take shape. However, how these cortical
flows interact with adjacent cytoplasmic components, changing their form and localization,
and how this affects cytoplasmic organization and cell shape remains unclear.
Here we show that in ascidian oocytes, the cooperative activities of cortical
actomyosin flows and deformation of the adjacent mitochondria-rich myoplasm drive
oocyte cytoplasmic reorganization and shape changes following fertilization. We
show that vegetal-directed cortical actomyosin flows, established upon oocyte
fertilization, lead to both the accumulation of cortical actin at the vegetal
pole of the zygote and compression and local buckling of the adjacent elastic
solid-like myoplasm layer due to friction forces generated at their interface.
Once cortical flows have ceased, the multiple myoplasm buckles resolve into one
larger buckle, which again drives the formation of the contraction pole—a protuberance
of the zygote’s vegetal pole where maternal mRNAs accumulate. Thus, our findings
reveal a mechanism where cortical actomyosin network flows determine cytoplasmic
reorganization and cell shape by deforming adjacent cytoplasmic components through
friction forces.
acknowledged_ssus:
- _id: EM-Fac
- _id: Bio
- _id: NanoFab
acknowledgement: We would like to thank A. McDougall, E. Hannezo and the Heisenberg
lab for fruitful discussions and reagents. We also thank E. Munro for the iMyo-YFP
and Bra>iMyo-mScarlet constructs. This research was supported by the Scientific
Service Units of the Institute of Science and Technology Austria through resources
provided by the Electron Microscopy Facility, Imaging and Optics Facility and the
Nanofabrication Facility. This work was supported by a Joint Project Grant from
the FWF (I 3601-B27).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Silvia
full_name: Caballero Mancebo, Silvia
id: 2F1E1758-F248-11E8-B48F-1D18A9856A87
last_name: Caballero Mancebo
orcid: 0000-0002-5223-3346
- first_name: Rushikesh
full_name: Shinde, Rushikesh
last_name: Shinde
- first_name: Madison
full_name: Bolger-Munro, Madison
id: 516F03FA-93A3-11EA-A7C5-D6BE3DDC885E
last_name: Bolger-Munro
orcid: 0000-0002-8176-4824
- first_name: Matilda
full_name: Peruzzo, Matilda
id: 3F920B30-F248-11E8-B48F-1D18A9856A87
last_name: Peruzzo
orcid: 0000-0002-3415-4628
- first_name: Gregory
full_name: Szep, Gregory
id: 4BFB7762-F248-11E8-B48F-1D18A9856A87
last_name: Szep
- first_name: Irene
full_name: Steccari, Irene
id: 2705C766-9FE2-11EA-B224-C6773DDC885E
last_name: Steccari
- first_name: David
full_name: Labrousse Arias, David
id: CD573DF4-9ED3-11E9-9D77-3223E6697425
last_name: Labrousse Arias
- first_name: Vanessa
full_name: Zheden, Vanessa
id: 39C5A68A-F248-11E8-B48F-1D18A9856A87
last_name: Zheden
orcid: 0000-0002-9438-4783
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Andrew
full_name: Callan-Jones, Andrew
last_name: Callan-Jones
- first_name: Raphaël
full_name: Voituriez, Raphaël
last_name: Voituriez
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Caballero Mancebo S, Shinde R, Bolger-Munro M, et al. Friction forces determine
cytoplasmic reorganization and shape changes of ascidian oocytes upon fertilization.
Nature Physics. 2024;20:310-321. doi:10.1038/s41567-023-02302-1
apa: Caballero Mancebo, S., Shinde, R., Bolger-Munro, M., Peruzzo, M., Szep, G.,
Steccari, I., … Heisenberg, C.-P. J. (2024). Friction forces determine cytoplasmic
reorganization and shape changes of ascidian oocytes upon fertilization. Nature
Physics. Springer Nature. https://doi.org/10.1038/s41567-023-02302-1
chicago: Caballero Mancebo, Silvia, Rushikesh Shinde, Madison Bolger-Munro, Matilda
Peruzzo, Gregory Szep, Irene Steccari, David Labrousse Arias, et al. “Friction
Forces Determine Cytoplasmic Reorganization and Shape Changes of Ascidian Oocytes
upon Fertilization.” Nature Physics. Springer Nature, 2024. https://doi.org/10.1038/s41567-023-02302-1.
ieee: S. Caballero Mancebo et al., “Friction forces determine cytoplasmic
reorganization and shape changes of ascidian oocytes upon fertilization,” Nature
Physics, vol. 20. Springer Nature, pp. 310–321, 2024.
ista: Caballero Mancebo S, Shinde R, Bolger-Munro M, Peruzzo M, Szep G, Steccari
I, Labrousse Arias D, Zheden V, Merrin J, Callan-Jones A, Voituriez R, Heisenberg
C-PJ. 2024. Friction forces determine cytoplasmic reorganization and shape changes
of ascidian oocytes upon fertilization. Nature Physics. 20, 310–321.
mla: Caballero Mancebo, Silvia, et al. “Friction Forces Determine Cytoplasmic Reorganization
and Shape Changes of Ascidian Oocytes upon Fertilization.” Nature Physics,
vol. 20, Springer Nature, 2024, pp. 310–21, doi:10.1038/s41567-023-02302-1.
short: S. Caballero Mancebo, R. Shinde, M. Bolger-Munro, M. Peruzzo, G. Szep, I.
Steccari, D. Labrousse Arias, V. Zheden, J. Merrin, A. Callan-Jones, R. Voituriez,
C.-P.J. Heisenberg, Nature Physics 20 (2024) 310–321.
corr_author: '1'
date_created: 2024-01-21T23:00:57Z
date_published: 2024-02-01T00:00:00Z
date_updated: 2025-09-04T11:48:28Z
day: '01'
ddc:
- '530'
department:
- _id: CaHe
- _id: JoFi
- _id: MiSi
- _id: EM-Fac
- _id: NanoFab
doi: 10.1038/s41567-023-02302-1
external_id:
isi:
- '001138880800005'
pmid:
- '38370025'
file:
- access_level: open_access
checksum: 7891ebe7c900ae47469ab127031dd1ec
content_type: application/pdf
creator: dernst
date_created: 2024-07-16T12:12:43Z
date_updated: 2024-07-16T12:12:43Z
file_id: '17267'
file_name: 2024_NaturePhysics_CaballeroMancebo.pdf
file_size: 9897883
relation: main_file
success: 1
file_date_updated: 2024-07-16T12:12:43Z
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 310-321
pmid: 1
project:
- _id: 2646861A-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I03601
name: Control of embryonic cleavage pattern
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/stranger-than-friction-a-force-initiating-life/
scopus_import: '1'
status: public
title: Friction forces determine cytoplasmic reorganization and shape changes of ascidian
oocytes upon fertilization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 20
year: '2024'
...
---
_id: '17128'
abstract:
- lang: eng
text: The onset of turbulence in pipe flow has defied detailed understanding ever
since the first observations of the spatially heterogeneous nature of the transition.
Recent theoretical studies and experiments in simpler, shear-driven flows suggest
that the onset of turbulence is a directed-percolation non-equilibrium phase transition,
but whether these findings are generic and also apply to open or pressure-driven
flows is unknown. In pipe flow, the extremely long time scales near the transition
make direct observations of critical behaviour virtually impossible. Here we find
a technical solution to that limitation and show that the universality class of
the transition is directed percolation, from which a jammed phase of puffs emerges
above the critical point. Our method is to experimentally characterize all pairwise
interactions between localized patches of turbulence puffs and use these interactions
as input for renormalization group and computer simulations of minimal models
that extrapolate to long length and time scales. The strong interactions in the
jamming regime enable us to explicitly measure the turbulent fraction and confirm
model predictions. Our work shows that directed-percolation scaling applies beyond
simple closed shear flows and underscores how statistical mechanics can lead to
profound, quantitative and predictive insights on turbulent flows and their phases.
acknowledgement: We gratefully acknowledge the assistance of J. M. Lopez with DNSs
at an early stage of this work. This work was partially supported by two grants
from the Simons Foundation (grant nos. 662985 (N.G.) and 662960 (B.H.)) and by Ministry
of Science and Technology, Taiwan (grant nos. MOST 109-2112-M-001-017-MY3 and MOST
111-2112-M-001-027-MY3 (H.-Y.S.)). Part of this work was performed using computing
resources of CRIANN (Normandy, France).
article_processing_charge: No
article_type: original
author:
- first_name: Grégoire M
full_name: Lemoult, Grégoire M
id: 4787FE80-F248-11E8-B48F-1D18A9856A87
last_name: Lemoult
- first_name: Mukund
full_name: Vasudevan, Mukund
id: 3C5A959A-F248-11E8-B48F-1D18A9856A87
last_name: Vasudevan
- first_name: Hong Yan
full_name: Shih, Hong Yan
last_name: Shih
- first_name: Gaute
full_name: Linga, Gaute
last_name: Linga
- first_name: Joachim
full_name: Mathiesen, Joachim
last_name: Mathiesen
- first_name: Nigel
full_name: Goldenfeld, Nigel
last_name: Goldenfeld
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Lemoult GM, Vasudevan M, Shih HY, et al. Directed percolation and puff jamming
near the transition to pipe turbulence. Nature Physics. 2024;20:1339-1345.
doi:10.1038/s41567-024-02513-0
apa: Lemoult, G. M., Vasudevan, M., Shih, H. Y., Linga, G., Mathiesen, J., Goldenfeld,
N., & Hof, B. (2024). Directed percolation and puff jamming near the transition
to pipe turbulence. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-024-02513-0
chicago: Lemoult, Grégoire M, Mukund Vasudevan, Hong Yan Shih, Gaute Linga, Joachim
Mathiesen, Nigel Goldenfeld, and Björn Hof. “Directed Percolation and Puff Jamming
near the Transition to Pipe Turbulence.” Nature Physics. Springer Nature,
2024. https://doi.org/10.1038/s41567-024-02513-0.
ieee: G. M. Lemoult et al., “Directed percolation and puff jamming near the
transition to pipe turbulence,” Nature Physics, vol. 20. Springer Nature,
pp. 1339–1345, 2024.
ista: Lemoult GM, Vasudevan M, Shih HY, Linga G, Mathiesen J, Goldenfeld N, Hof
B. 2024. Directed percolation and puff jamming near the transition to pipe turbulence.
Nature Physics. 20, 1339–1345.
mla: Lemoult, Grégoire M., et al. “Directed Percolation and Puff Jamming near the
Transition to Pipe Turbulence.” Nature Physics, vol. 20, Springer Nature,
2024, pp. 1339–45, doi:10.1038/s41567-024-02513-0.
short: G.M. Lemoult, M. Vasudevan, H.Y. Shih, G. Linga, J. Mathiesen, N. Goldenfeld,
B. Hof, Nature Physics 20 (2024) 1339–1345.
corr_author: '1'
date_created: 2024-06-09T22:01:03Z
date_published: 2024-08-01T00:00:00Z
date_updated: 2025-09-08T07:50:20Z
day: '01'
department:
- _id: BjHo
doi: 10.1038/s41567-024-02513-0
external_id:
isi:
- '001232300600001'
intvolume: ' 20'
isi: 1
language:
- iso: eng
month: '08'
oa_version: None
page: 1339-1345
project:
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
grant_number: '662960'
name: Revisiting the Turbulence Problem Using Statistical Mechanics
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Directed percolation and puff jamming near the transition to pipe turbulence
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 20
year: '2024'
...
---
OA_place: repository
OA_type: green
_id: '17269'
abstract:
- lang: eng
text: The directed migration of epithelial cell collectives through coordinated
movements plays a crucial role in various physiological processes and is increasingly
understood at the level of large confluent monolayers. However, numerous processes
rely on the migration of small groups of polarized epithelial clusters in complex
environments, and their responses to external geometries remain poorly understood.
To address this, we cultivate primary epithelial keratocyte tissues on adhesive
microstripes to create autonomous epithelial clusters with well-defined geometries.
We show that their migration efficiency is strongly influenced by the contact
geometry and the orientation of cell–cell contacts with respect to the direction
of migration. A combination of velocity and polarity alignment with contact regulation
of locomotion in an active matter model captures quantitatively the experimental
data. Furthermore, we predict that this combination of rules enables efficient
navigation in complex geometries, which we confirm experimentally. Altogether,
our findings provide a conceptual framework for extracting the interaction rules
of active systems from their interaction with physical boundaries, as well as
design principles for collective navigation in complex microenvironments.
acknowledgement: M.L., E.V. and S.G. acknowledge funding from the European Regional
Development Fund (ERDF) Prostem Research Project (No. 1510614, Wallonia DG06), the
Epiforce Project of the National Fund for Scientific Research, Belgium (FRS-FNRS;
Project No. T.0092.21), the Cellsqueezer Project of FRS-FNRS (Project No. J.0061.23),
the Optopattern Project of FRS-FNRS (Project no. U.NO26.22) and the Interreg MAT(T)ISSE
project, which is financially supported by Interreg France-Wallonie-Vlaanderen,
ERDF). A.R. and M.L. are financially supported by FRS-FNRS as a research fellow
(Aspirant FNRS) and Postdoctoral Researcher (Chargée de Recherches FNRS), respectively.
E.V. and Y.K. are financially supported by FRS-FNRS through grants from the Fund
for Research Training in Industry and Agriculture (FRIA). This project was supported
by the European Research Council under the European Union’s Horizon 2020 Research
and Innovation Programme (Grant Agreement No. 851288 to E.H.) and Marie Skłodowska-Curie
Actions (Grant Agreement No. 797621 to M.G.-G.). D.B.B. was supported by the NOMIS
foundation as a NOMIS fellow and by the European Molecular Biology Organization
(Postdoctoral Fellowship ALTF 343-2022) and performed this work in part at the Aspen
Center for Physics, which is supported by the National Science Foundation (Grant
No. PHY-1607611). X.T. and M.G.-G. acknowledge support from the Government of Catalonia
(Grant No. AGAUR SGR-2017-01602 and a CERCA Programme), the Spanish Ministry for
Science and Innovation and ERDF (Grant No. PGC2018-099645-B-I00), the European Research
Council (Grant No. Adv-883739), Fundació la Marató de TV3 (201903-30-31-32), the
European Commission (Grant No. H2020-FETPROACT-01-2016-731957), La Caixa Foundation
and the Biomedical Research Center Consortium in Red (Grant No. CB15/00153) at the
Carlos III Health Institute, Ministry of Science and Innovation. IBEC is recipient
of a Severo Ochoa Award of Excellence from the Spanish Ministry of Economy, Trade
and Business.
article_processing_charge: No
article_type: original
author:
- first_name: Eléonore
full_name: Vercruysse, Eléonore
last_name: Vercruysse
- first_name: David
full_name: Brückner, David
id: e1e86031-6537-11eb-953a-f7ab92be508d
last_name: Brückner
orcid: 0000-0001-7205-2975
- first_name: Manuel
full_name: Gómez-González, Manuel
last_name: Gómez-González
- first_name: Alexandre
full_name: Remson, Alexandre
last_name: Remson
- first_name: Marine
full_name: Luciano, Marine
last_name: Luciano
- first_name: Yohalie
full_name: Kalukula, Yohalie
last_name: Kalukula
- first_name: Leone
full_name: Rossetti, Leone
last_name: Rossetti
- first_name: Xavier
full_name: Trepat, Xavier
last_name: Trepat
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Sylvain
full_name: Gabriele, Sylvain
last_name: Gabriele
citation:
ama: Vercruysse E, Brückner D, Gómez-González M, et al. Geometry-driven migration
efficiency of autonomous epithelial cell clusters. Nature Physics. 2024;20:1492-1500.
doi:10.1038/s41567-024-02532-x
apa: Vercruysse, E., Brückner, D., Gómez-González, M., Remson, A., Luciano, M.,
Kalukula, Y., … Gabriele, S. (2024). Geometry-driven migration efficiency of autonomous
epithelial cell clusters. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-024-02532-x
chicago: Vercruysse, Eléonore, David Brückner, Manuel Gómez-González, Alexandre
Remson, Marine Luciano, Yohalie Kalukula, Leone Rossetti, Xavier Trepat, Edouard
B Hannezo, and Sylvain Gabriele. “Geometry-Driven Migration Efficiency of Autonomous
Epithelial Cell Clusters.” Nature Physics. Springer Nature, 2024. https://doi.org/10.1038/s41567-024-02532-x.
ieee: E. Vercruysse et al., “Geometry-driven migration efficiency of autonomous
epithelial cell clusters,” Nature Physics, vol. 20. Springer Nature, pp.
1492–1500, 2024.
ista: Vercruysse E, Brückner D, Gómez-González M, Remson A, Luciano M, Kalukula
Y, Rossetti L, Trepat X, Hannezo EB, Gabriele S. 2024. Geometry-driven migration
efficiency of autonomous epithelial cell clusters. Nature Physics. 20, 1492–1500.
mla: Vercruysse, Eléonore, et al. “Geometry-Driven Migration Efficiency of Autonomous
Epithelial Cell Clusters.” Nature Physics, vol. 20, Springer Nature, 2024,
pp. 1492–500, doi:10.1038/s41567-024-02532-x.
short: E. Vercruysse, D. Brückner, M. Gómez-González, A. Remson, M. Luciano, Y.
Kalukula, L. Rossetti, X. Trepat, E.B. Hannezo, S. Gabriele, Nature Physics 20
(2024) 1492–1500.
corr_author: '1'
date_created: 2024-07-16T12:32:17Z
date_published: 2024-09-01T00:00:00Z
date_updated: 2025-09-08T08:28:31Z
day: '01'
department:
- _id: EdHa
doi: 10.1038/s41567-024-02532-x
ec_funded: 1
external_id:
isi:
- '001250246200004'
intvolume: ' 20'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1101/2022.07.17.500364
month: '09'
oa: 1
oa_version: Preprint
page: 1492-1500
project:
- _id: 05943252-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '851288'
name: Design Principles of Branching Morphogenesis
- _id: 34e2a5b5-11ca-11ed-8bc3-b2265616ef0b
grant_number: ALTF 343-2022
name: A mechano-chemical theory for stem cell fate decisions in organoid development
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/a-railroad-of-cells/
scopus_import: '1'
status: public
title: Geometry-driven migration efficiency of autonomous epithelial cell clusters
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 20
year: '2024'
...
---
APC_amount: 12348 EUR
OA_place: publisher
OA_type: hybrid
_id: '17460'
abstract:
- lang: eng
text: Filaments in the cell commonly treadmill. Driven by energy consumption, they
grow on one end while shrinking on the other, causing filaments to appear motile
even though individual proteins remain static. This process is characteristic
of cytoskeletal filaments and leads to collective filament self-organization.
Here we show that treadmilling drives filament nematic ordering by dissolving
misaligned filaments. Taking the bacterial FtsZ protein involved in cell division
as an example, we show that this mechanism aligns FtsZ filaments in vitro and
drives the organization of the division ring in living Bacillus subtilis cells.
We find that ordering via local dissolution also allows the system to quickly
respond to chemical and geometrical biases in the cell, enabling us to quantitatively
explain the ring formation dynamics in vivo. Beyond FtsZ and other cytoskeletal
filaments, our study identifies a mechanism for self-organization via constant
birth and death of energy-consuming filaments.
acknowledgement: We thank I. Palaia (ISTA) for useful discussions and K. Lim and R.
W. Wong (WPI-Nano Life Science Institute, Kanazawa University) for providing access
to HS-AFM. We would like to thank B. Prats Mateu (MSD Austria, Vienna) for providing
the HS-AFM data. This work was supported by the Royal Society (grant no. UF160266;
C.V.-C. and A.Š.), the European Union’s Horizon 2020 Research and Innovation Programme
(grant no. 802960; A.Š.), the Austrian Science Fund (FWF) Stand-Alone P34607 (M.L.)
and a Wellcome Trust and Royal Society Sir Henry Dale Fellowship (grant no. 206670/Z/17/Z;
S.H. and K.D.W.).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Christian Eduardo
full_name: Vanhille-Campos, Christian Eduardo
id: 3adeca52-9313-11ed-b1ac-c170b2505714
last_name: Vanhille-Campos
- first_name: Kevin D.
full_name: Whitley, Kevin D.
last_name: Whitley
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
- first_name: Séamus
full_name: Holden, Séamus
last_name: Holden
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
citation:
ama: Vanhille-Campos CE, Whitley KD, Radler P, Loose M, Holden S, Šarić A. Self-organization
of mortal filaments and its role in bacterial division ring formation. Nature
Physics. 2024;20:1670-1678. doi:10.1038/s41567-024-02597-8
apa: Vanhille-Campos, C. E., Whitley, K. D., Radler, P., Loose, M., Holden, S.,
& Šarić, A. (2024). Self-organization of mortal filaments and its role in
bacterial division ring formation. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-024-02597-8
chicago: Vanhille-Campos, Christian Eduardo, Kevin D. Whitley, Philipp Radler, Martin
Loose, Séamus Holden, and Anđela Šarić. “Self-Organization of Mortal Filaments
and Its Role in Bacterial Division Ring Formation.” Nature Physics. Springer
Nature, 2024. https://doi.org/10.1038/s41567-024-02597-8.
ieee: C. E. Vanhille-Campos, K. D. Whitley, P. Radler, M. Loose, S. Holden, and
A. Šarić, “Self-organization of mortal filaments and its role in bacterial division
ring formation,” Nature Physics, vol. 20. Springer Nature, pp. 1670–1678,
2024.
ista: Vanhille-Campos CE, Whitley KD, Radler P, Loose M, Holden S, Šarić A. 2024.
Self-organization of mortal filaments and its role in bacterial division ring
formation. Nature Physics. 20, 1670–1678.
mla: Vanhille-Campos, Christian Eduardo, et al. “Self-Organization of Mortal Filaments
and Its Role in Bacterial Division Ring Formation.” Nature Physics, vol.
20, Springer Nature, 2024, pp. 1670–78, doi:10.1038/s41567-024-02597-8.
short: C.E. Vanhille-Campos, K.D. Whitley, P. Radler, M. Loose, S. Holden, A. Šarić,
Nature Physics 20 (2024) 1670–1678.
corr_author: '1'
date_created: 2024-08-25T22:01:08Z
date_published: 2024-10-01T00:00:00Z
date_updated: 2025-09-08T09:02:20Z
day: '01'
ddc:
- '570'
department:
- _id: AnSa
- _id: MaLo
doi: 10.1038/s41567-024-02597-8
ec_funded: 1
external_id:
isi:
- '001289394500005'
pmid:
- '39416851'
file:
- access_level: open_access
checksum: c4842152e2b90d67f48ea8c9ed7c473b
content_type: application/pdf
creator: dernst
date_created: 2025-04-14T06:06:35Z
date_updated: 2025-04-14T06:06:35Z
file_id: '19556'
file_name: 2024_NaturePhysics_VanhilleCampos.pdf
file_size: 8058249
relation: main_file
success: 1
file_date_updated: 2025-04-14T06:06:35Z
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
page: 1670-1678
pmid: 1
project:
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
grant_number: P34607
name: In vitro reconstitution of bacterial cell division
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Self-organization of mortal filaments and its role in bacterial division ring
formation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 317138e5-6ab7-11ef-aa6d-ffef3953e345
volume: 20
year: '2024'
...
---
_id: '13971'
abstract:
- lang: eng
text: When in equilibrium, thermal forces agitate molecules, which then diffuse,
collide and bind to form materials. However, the space of accessible structures
in which micron-scale particles can be organized by thermal forces is limited,
owing to the slow dynamics and metastable states. Active agents in a passive fluid
generate forces and flows, forming a bath with active fluctuations. Two unanswered
questions are whether those active agents can drive the assembly of passive components
into unconventional states and which material properties they will exhibit. Here
we show that passive, sticky beads immersed in a bath of swimming Escherichia
coli bacteria aggregate into unconventional clusters and gels that are controlled
by the activity of the bath. We observe a slow but persistent rotation of the
aggregates that originates in the chirality of the E. coli flagella and directs
aggregation into structures that are not accessible thermally. We elucidate the
aggregation mechanism with a numerical model of spinning, sticky beads and reproduce
quantitatively the experimental results. We show that internal activity controls
the phase diagram and the structure of the aggregates. Overall, our results highlight
the promising role of active baths in designing the structural and mechanical
properties of materials with unconventional phases.
acknowledgement: D.G. and J.P. thank E. Krasnopeeva, C. Guet, G. Guessous and T. Hwa
for providing the E. coli strains. This material is based upon work supported by
the US Department of Energy under award DE-SC0019769. I.P. acknowledges funding
by the European Union’s Horizon 2020 research and innovation programme under Marie
Skłodowska-Curie Grant Agreement No. 101034413. A.Š. acknowledges funding from the
European Research Council under the European Union’s Horizon 2020 research and innovation
programme (Grant No. 802960). M.C.U. acknowledges funding from the European Union’s
Horizon 2020 research and innovation programme under Marie Skłodowska-Curie Grant
Agreement No. 754411.
article_processing_charge: Yes
article_type: original
author:
- first_name: Daniel
full_name: Grober, Daniel
id: abdfc56f-34fb-11ee-bd33-fd766fce5a99
last_name: Grober
- first_name: Ivan
full_name: Palaia, Ivan
id: 9c805cd2-4b75-11ec-a374-db6dd0ed57fa
last_name: Palaia
orcid: ' 0000-0002-8843-9485 '
- first_name: Mehmet C
full_name: Ucar, Mehmet C
id: 50B2A802-6007-11E9-A42B-EB23E6697425
last_name: Ucar
orcid: 0000-0003-0506-4217
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Anđela
full_name: Šarić, Anđela
id: bf63d406-f056-11eb-b41d-f263a6566d8b
last_name: Šarić
orcid: 0000-0002-7854-2139
- first_name: Jérémie A
full_name: Palacci, Jérémie A
id: 8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d
last_name: Palacci
orcid: 0000-0002-7253-9465
citation:
ama: Grober D, Palaia I, Ucar MC, Hannezo EB, Šarić A, Palacci JA. Unconventional
colloidal aggregation in chiral bacterial baths. Nature Physics. 2023;19:1680-1688.
doi:10.1038/s41567-023-02136-x
apa: Grober, D., Palaia, I., Ucar, M. C., Hannezo, E. B., Šarić, A., & Palacci,
J. A. (2023). Unconventional colloidal aggregation in chiral bacterial baths.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-023-02136-x
chicago: Grober, Daniel, Ivan Palaia, Mehmet C Ucar, Edouard B Hannezo, Anđela Šarić,
and Jérémie A Palacci. “Unconventional Colloidal Aggregation in Chiral Bacterial
Baths.” Nature Physics. Springer Nature, 2023. https://doi.org/10.1038/s41567-023-02136-x.
ieee: D. Grober, I. Palaia, M. C. Ucar, E. B. Hannezo, A. Šarić, and J. A. Palacci,
“Unconventional colloidal aggregation in chiral bacterial baths,” Nature Physics,
vol. 19. Springer Nature, pp. 1680–1688, 2023.
ista: Grober D, Palaia I, Ucar MC, Hannezo EB, Šarić A, Palacci JA. 2023. Unconventional
colloidal aggregation in chiral bacterial baths. Nature Physics. 19, 1680–1688.
mla: Grober, Daniel, et al. “Unconventional Colloidal Aggregation in Chiral Bacterial
Baths.” Nature Physics, vol. 19, Springer Nature, 2023, pp. 1680–88, doi:10.1038/s41567-023-02136-x.
short: D. Grober, I. Palaia, M.C. Ucar, E.B. Hannezo, A. Šarić, J.A. Palacci, Nature
Physics 19 (2023) 1680–1688.
corr_author: '1'
date_created: 2023-08-06T22:01:11Z
date_published: 2023-11-01T00:00:00Z
date_updated: 2025-04-14T07:43:56Z
day: '01'
ddc:
- '530'
department:
- _id: EdHa
- _id: AnSa
- _id: JePa
doi: 10.1038/s41567-023-02136-x
ec_funded: 1
external_id:
isi:
- '001037346400005'
file:
- access_level: open_access
checksum: 7e282c2ebc0ac82125a04f6b4742d4c1
content_type: application/pdf
creator: dernst
date_created: 2024-01-30T12:26:08Z
date_updated: 2024-01-30T12:26:08Z
file_id: '14906'
file_name: 2023_NaturePhysics_Grober.pdf
file_size: 6365607
relation: main_file
success: 1
file_date_updated: 2024-01-30T12:26:08Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1680-1688
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
- _id: eba2549b-77a9-11ec-83b8-a81e493eae4e
call_identifier: H2020
grant_number: '802960'
name: 'Non-Equilibrium Protein Assembly: from Building Blocks to Biological Machines'
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unconventional colloidal aggregation in chiral bacterial baths
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
_id: '18190'
abstract:
- lang: eng
text: Strongly correlated systems can exhibit unexpected phenomena when brought
in a state far from equilibrium. An example is many-body localization, which prevents
generic interacting systems from reaching thermal equilibrium even at long times1,2.
The stability of the many-body localized phase has been predicted to be hindered
by the presence of small thermal inclusions that act as a bath, leading to the
delocalization of the entire system through an avalanche propagation mechanism3,4,5,6,7,8.
Here we study the dynamics of a thermal inclusion of variable size when it is
coupled to a many-body localized system. We find evidence for accelerated transport
of thermal inclusion into the localized region. We monitor how the avalanche spreads
through the localized system and thermalizes it site by site by measuring the
site-resolved entropy over time. Furthermore, we isolate the strongly correlated
bath-induced dynamics with multipoint correlations between the bath and the system.
Our results have implications on the robustness of many-body localized systems
and their critical behaviour.
article_processing_charge: No
article_type: letter_note
arxiv: 1
author:
- first_name: Julian
full_name: Leonard, Julian
id: b75b3f45-7995-11ef-9bfd-9a9cd02c3577
last_name: Leonard
- first_name: Sooshin
full_name: Kim, Sooshin
last_name: Kim
- first_name: Matthew
full_name: Rispoli, Matthew
last_name: Rispoli
- first_name: Alexander
full_name: Lukin, Alexander
last_name: Lukin
- first_name: Robert
full_name: Schittko, Robert
last_name: Schittko
- first_name: Joyce
full_name: Kwan, Joyce
last_name: Kwan
- first_name: Eugene
full_name: Demler, Eugene
last_name: Demler
- first_name: Dries
full_name: Sels, Dries
last_name: Sels
- first_name: Markus
full_name: Greiner, Markus
last_name: Greiner
citation:
ama: Leonard J, Kim S, Rispoli M, et al. Probing the onset of quantum avalanches
in a many-body localized system. Nature Physics. 2023;19(4):481-485. doi:10.1038/s41567-022-01887-3
apa: Leonard, J., Kim, S., Rispoli, M., Lukin, A., Schittko, R., Kwan, J., … Greiner,
M. (2023). Probing the onset of quantum avalanches in a many-body localized system.
Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-022-01887-3
chicago: Leonard, Julian, Sooshin Kim, Matthew Rispoli, Alexander Lukin, Robert
Schittko, Joyce Kwan, Eugene Demler, Dries Sels, and Markus Greiner. “Probing
the Onset of Quantum Avalanches in a Many-Body Localized System.” Nature Physics.
Springer Nature, 2023. https://doi.org/10.1038/s41567-022-01887-3.
ieee: J. Leonard et al., “Probing the onset of quantum avalanches in a many-body
localized system,” Nature Physics, vol. 19, no. 4. Springer Nature, pp.
481–485, 2023.
ista: Leonard J, Kim S, Rispoli M, Lukin A, Schittko R, Kwan J, Demler E, Sels D,
Greiner M. 2023. Probing the onset of quantum avalanches in a many-body localized
system. Nature Physics. 19(4), 481–485.
mla: Leonard, Julian, et al. “Probing the Onset of Quantum Avalanches in a Many-Body
Localized System.” Nature Physics, vol. 19, no. 4, Springer Nature, 2023,
pp. 481–85, doi:10.1038/s41567-022-01887-3.
short: J. Leonard, S. Kim, M. Rispoli, A. Lukin, R. Schittko, J. Kwan, E. Demler,
D. Sels, M. Greiner, Nature Physics 19 (2023) 481–485.
date_created: 2024-10-07T11:46:33Z
date_published: 2023-01-26T00:00:00Z
date_updated: 2024-10-08T10:52:08Z
day: '26'
doi: 10.1038/s41567-022-01887-3
extern: '1'
external_id:
arxiv:
- '2012.15270'
intvolume: ' 19'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2012.15270
month: '01'
oa: 1
oa_version: Preprint
page: 481-485
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Probing the onset of quantum avalanches in a many-body localized system
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
_id: '13118'
abstract:
- lang: eng
text: Under high pressures and temperatures, molecular systems with substantial
polarization charges, such as ammonia and water, are predicted to form superionic
phases and dense fluid states with dissociating molecules and high electrical
conductivity. This behaviour potentially plays a role in explaining the origin
of the multipolar magnetic fields of Uranus and Neptune, whose mantles are thought
to result from a mixture of H2O, NH3 and CH4 ices. Determining the stability domain,
melting curve and electrical conductivity of these superionic phases is therefore
crucial for modelling planetary interiors and dynamos. Here we report the melting
curve of superionic ammonia up to 300 GPa from laser-driven shock compression
of pre-compressed samples and atomistic calculations. We show that ammonia melts
at lower temperatures than water above 100 GPa and that fluid ammonia’s electrical
conductivity exceeds that of water at conditions predicted by hot, super-adiabatic
models for Uranus and Neptune, and enhances the conductivity in their fluid water-rich
dynamo layers.
acknowledgement: We acknowledge the crucial contribution of the LULI2000 laser and
support teams to the success of the experiments. We also thank S. Brygoo and P.
Loubeyre for useful discussions. This research was supported by the French National
Research Agency (ANR) through the projects POMPEI (grant no. ANR-16-CE31-0008) and
SUPER-ICES (grant ANR-15-CE30-008-01), and by the PLAS@PAR Federation. M.F. and
R.R. gratefully acknowledge support by the DFG within the Research Unit FOR 2440.
M.B. was supported by the European Union within the Marie Skłodowska-Curie actions
(xICE grant 894725) and the NOMIS foundation. The DFT-MD calculations were performed
at the North-German Supercomputing Alliance facilities.
article_processing_charge: No
article_type: original
author:
- first_name: J.-A.
full_name: Hernandez, J.-A.
last_name: Hernandez
- first_name: Mandy
full_name: Bethkenhagen, Mandy
id: 201939f4-803f-11ed-ab7e-d8da4bd1517f
last_name: Bethkenhagen
orcid: 0000-0002-1838-2129
- first_name: S.
full_name: Ninet, S.
last_name: Ninet
- first_name: M.
full_name: French, M.
last_name: French
- first_name: A.
full_name: Benuzzi-Mounaix, A.
last_name: Benuzzi-Mounaix
- first_name: F.
full_name: Datchi, F.
last_name: Datchi
- first_name: M.
full_name: Guarguaglini, M.
last_name: Guarguaglini
- first_name: F.
full_name: Lefevre, F.
last_name: Lefevre
- first_name: F.
full_name: Occelli, F.
last_name: Occelli
- first_name: R.
full_name: Redmer, R.
last_name: Redmer
- first_name: T.
full_name: Vinci, T.
last_name: Vinci
- first_name: A.
full_name: Ravasio, A.
last_name: Ravasio
citation:
ama: Hernandez J-A, Bethkenhagen M, Ninet S, et al. Melting curve of superionic
ammonia at planetary interior conditions. Nature Physics. 2023;19:1280-1285.
doi:10.1038/s41567-023-02074-8
apa: Hernandez, J.-A., Bethkenhagen, M., Ninet, S., French, M., Benuzzi-Mounaix,
A., Datchi, F., … Ravasio, A. (2023). Melting curve of superionic ammonia at planetary
interior conditions. Nature Physics. Springer Nature. https://doi.org/10.1038/s41567-023-02074-8
chicago: Hernandez, J.-A., Mandy Bethkenhagen, S. Ninet, M. French, A. Benuzzi-Mounaix,
F. Datchi, M. Guarguaglini, et al. “Melting Curve of Superionic Ammonia at Planetary
Interior Conditions.” Nature Physics. Springer Nature, 2023. https://doi.org/10.1038/s41567-023-02074-8.
ieee: J.-A. Hernandez et al., “Melting curve of superionic ammonia at planetary
interior conditions,” Nature Physics, vol. 19. Springer Nature, pp. 1280–1285,
2023.
ista: Hernandez J-A, Bethkenhagen M, Ninet S, French M, Benuzzi-Mounaix A, Datchi
F, Guarguaglini M, Lefevre F, Occelli F, Redmer R, Vinci T, Ravasio A. 2023. Melting
curve of superionic ammonia at planetary interior conditions. Nature Physics.
19, 1280–1285.
mla: Hernandez, J. A., et al. “Melting Curve of Superionic Ammonia at Planetary
Interior Conditions.” Nature Physics, vol. 19, Springer Nature, 2023, pp.
1280–85, doi:10.1038/s41567-023-02074-8.
short: J.-A. Hernandez, M. Bethkenhagen, S. Ninet, M. French, A. Benuzzi-Mounaix,
F. Datchi, M. Guarguaglini, F. Lefevre, F. Occelli, R. Redmer, T. Vinci, A. Ravasio,
Nature Physics 19 (2023) 1280–1285.
date_created: 2023-06-04T22:01:02Z
date_published: 2023-09-01T00:00:00Z
date_updated: 2024-08-20T05:59:32Z
day: '01'
department:
- _id: BiCh
doi: 10.1038/s41567-023-02074-8
external_id:
isi:
- '000996921200001'
intvolume: ' 19'
isi: 1
language:
- iso: eng
month: '09'
oa_version: None
page: 1280-1285
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1038/s41567-023-02130-3
scopus_import: '1'
status: public
title: Melting curve of superionic ammonia at planetary interior conditions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...