---
_id: '11100'
abstract:
- lang: eng
  text: Eukaryotic cell function depends on the physical separation of nucleoplasmic
    and cytoplasmic components by the nuclear envelope (NE). Molecular communication
    between the two compartments involves active, signal-mediated trafficking, a function
    that is exclusively performed by nuclear pore complexes (NPCs). The individual
    NPC components and the mechanisms that are involved in nuclear trafficking are
    well documented and have become textbook knowledge. However, in addition to their
    roles as nuclear gatekeepers, NPC components-nucleoporins-have been shown to have
    critical roles in chromatin organization and gene regulation. These findings have
    sparked new enthusiasm to study the roles of this multiprotein complex in nuclear
    organization and explore novel functions that in some cases appear to go beyond
    a role in transport. Here, we discuss our present view of NPC biogenesis, which
    is tightly linked to proper cell cycle progression and cell differentiation. In
    addition, we summarize new data suggesting that NPCs represent dynamic hubs for
    the integration of gene regulation and nuclear transport processes.
article_processing_charge: No
article_type: original
author:
- first_name: M.
  full_name: Capelson, M.
  last_name: Capelson
- first_name: C.
  full_name: Doucet, C.
  last_name: Doucet
- first_name: Martin W
  full_name: HETZER, Martin W
  id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
  last_name: HETZER
  orcid: 0000-0002-2111-992X
citation:
  ama: 'Capelson M, Doucet C, Hetzer M. Nuclear pore complexes: Guardians of the nuclear
    genome. <i>Cold Spring Harbor Symposia on Quantitative Biology</i>. 2011;75:585-597.
    doi:<a href="https://doi.org/10.1101/sqb.2010.75.059">10.1101/sqb.2010.75.059</a>'
  apa: 'Capelson, M., Doucet, C., &#38; Hetzer, M. (2011). Nuclear pore complexes:
    Guardians of the nuclear genome. <i>Cold Spring Harbor Symposia on Quantitative
    Biology</i>. Cold Spring Harbor Laboratory Press. <a href="https://doi.org/10.1101/sqb.2010.75.059">https://doi.org/10.1101/sqb.2010.75.059</a>'
  chicago: 'Capelson, M., C. Doucet, and Martin Hetzer. “Nuclear Pore Complexes: Guardians
    of the Nuclear Genome.” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>.
    Cold Spring Harbor Laboratory Press, 2011. <a href="https://doi.org/10.1101/sqb.2010.75.059">https://doi.org/10.1101/sqb.2010.75.059</a>.'
  ieee: 'M. Capelson, C. Doucet, and M. Hetzer, “Nuclear pore complexes: Guardians
    of the nuclear genome,” <i>Cold Spring Harbor Symposia on Quantitative Biology</i>,
    vol. 75. Cold Spring Harbor Laboratory Press, pp. 585–597, 2011.'
  ista: 'Capelson M, Doucet C, Hetzer M. 2011. Nuclear pore complexes: Guardians of
    the nuclear genome. Cold Spring Harbor Symposia on Quantitative Biology. 75, 585–597.'
  mla: 'Capelson, M., et al. “Nuclear Pore Complexes: Guardians of the Nuclear Genome.”
    <i>Cold Spring Harbor Symposia on Quantitative Biology</i>, vol. 75, Cold Spring
    Harbor Laboratory Press, 2011, pp. 585–97, doi:<a href="https://doi.org/10.1101/sqb.2010.75.059">10.1101/sqb.2010.75.059</a>.'
  short: M. Capelson, C. Doucet, M. Hetzer, Cold Spring Harbor Symposia on Quantitative
    Biology 75 (2011) 585–597.
date_created: 2022-04-07T07:53:18Z
date_published: 2011-04-18T00:00:00Z
date_updated: 2024-10-14T11:27:48Z
day: '18'
doi: 10.1101/sqb.2010.75.059
extern: '1'
external_id:
  pmid:
  - '21502404'
intvolume: '        75'
keyword:
- Genetics
- Molecular Biology
- Biochemistry
language:
- iso: eng
month: '04'
oa_version: None
page: 585-597
pmid: 1
publication: Cold Spring Harbor Symposia on Quantitative Biology
publication_identifier:
  isbn:
  - '9781936113071'
  issn:
  - 0091-7451
  - 1943-4456
publication_status: published
publisher: Cold Spring Harbor Laboratory Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Nuclear pore complexes: Guardians of the nuclear genome'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 75
year: '2011'
...