--- _id: '10103' abstract: - lang: eng text: The small cellular molecule inositol hexakisphosphate (IP6) has been known for ~20 years to promote the in vitro assembly of HIV-1 into immature virus-like particles. However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding site in the immature Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice via a second IP6 binding site, and enhances core stability, creating a favorable environment for reverse transcription. IP6 also enhances assembly of other retroviruses, from both the Lentivirus and the Alpharetrovirus genera. These findings suggest that IP6 may have a conserved function throughout the family Retroviridae. Here, we discuss the different steps in the viral life cycle that are influenced by IP6, and describe in detail how IP6 interacts with the immature and mature lattices of different retroviruses. acknowledgement: We thank Volker M. Vogt for his critical comments in preparation of the review. article_number: '1853' article_processing_charge: Yes article_type: original author: - first_name: Martin full_name: Obr, Martin id: 4741CA5A-F248-11E8-B48F-1D18A9856A87 last_name: Obr orcid: 0000-0003-1756-6564 - first_name: Florian KM full_name: Schur, Florian KM id: 48AD8942-F248-11E8-B48F-1D18A9856A87 last_name: Schur orcid: 0000-0003-4790-8078 - first_name: Robert A. full_name: Dick, Robert A. last_name: Dick citation: ama: Obr M, Schur FK, Dick RA. A structural perspective of the role of IP6 in immature and mature retroviral assembly. Viruses. 2021;13(9). doi:10.3390/v13091853 apa: Obr, M., Schur, F. K., & Dick, R. A. (2021). A structural perspective of the role of IP6 in immature and mature retroviral assembly. Viruses. MDPI. https://doi.org/10.3390/v13091853 chicago: Obr, Martin, Florian KM Schur, and Robert A. Dick. “A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.” Viruses. MDPI, 2021. https://doi.org/10.3390/v13091853. ieee: M. Obr, F. K. Schur, and R. A. Dick, “A structural perspective of the role of IP6 in immature and mature retroviral assembly,” Viruses, vol. 13, no. 9. MDPI, 2021. ista: Obr M, Schur FK, Dick RA. 2021. A structural perspective of the role of IP6 in immature and mature retroviral assembly. Viruses. 13(9), 1853. mla: Obr, Martin, et al. “A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.” Viruses, vol. 13, no. 9, 1853, MDPI, 2021, doi:10.3390/v13091853. short: M. Obr, F.K. Schur, R.A. Dick, Viruses 13 (2021). date_created: 2021-10-07T09:13:29Z date_published: 2021-09-17T00:00:00Z date_updated: 2023-08-14T07:21:51Z day: '17' ddc: - '616' department: - _id: FlSc doi: 10.3390/v13091853 external_id: isi: - '000699841100001' pmid: - '34578434' file: - access_level: open_access checksum: bcfd72a12977d48e22df3d0cc55aacf1 content_type: application/pdf creator: cchlebak date_created: 2021-10-08T10:38:15Z date_updated: 2021-10-08T10:38:15Z file_id: '10115' file_name: 2021_Viruses_Obr.pdf file_size: 4146796 relation: main_file success: 1 file_date_updated: 2021-10-08T10:38:15Z has_accepted_license: '1' intvolume: ' 13' isi: 1 issue: '9' keyword: - virology - infectious diseases language: - iso: eng license: https://creativecommons.org/licenses/by/4.0/ month: '09' oa: 1 oa_version: Published Version pmid: 1 project: - _id: 26736D6A-B435-11E9-9278-68D0E5697425 call_identifier: FWF grant_number: P31445 name: Structural conservation and diversity in retroviral capsid publication: Viruses publication_identifier: issn: - 1999-4915 publication_status: published publisher: MDPI quality_controlled: '1' status: public title: A structural perspective of the role of IP6 in immature and mature retroviral assembly tmp: image: /images/cc_by.png legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0) short: CC BY (4.0) type: journal_article user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8 volume: 13 year: '2021' ...