[{"external_id":{"pmid":["32973214"],"isi":["000573756600004"]},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Nature Communications","year":"2020","related_material":{"link":[{"url":"https://doi.org/10.1038/s41467-020-19720-x","relation":"erratum"}]},"status":"public","file_date_updated":"2020-09-28T13:16:15Z","publication_identifier":{"issn":["2041-1723"]},"intvolume":"        11","language":[{"iso":"eng"}],"corr_author":"1","file":[{"file_size":1822469,"creator":"dernst","file_id":"8585","date_updated":"2020-09-28T13:16:15Z","relation":"main_file","success":1,"content_type":"application/pdf","file_name":"2020_NatureComm_Prehal.pdf","access_level":"open_access","date_created":"2020-09-28T13:16:15Z","checksum":"eada7bc8dd16a49390137cff882ef328"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"month":"09","date_published":"2020-09-24T00:00:00Z","oa":1,"date_updated":"2025-06-12T06:58:51Z","quality_controlled":"1","day":"24","doi":"10.1038/s41467-020-18610-6","volume":11,"oa_version":"Published Version","date_created":"2020-09-25T07:23:13Z","department":[{"_id":"StFr"}],"citation":{"short":"C. Prehal, H. Fitzek, G. Kothleitner, V. Presser, B. Gollas, S.A. Freunberger, Q. Abbas, Nature Communications 11 (2020).","ieee":"C. Prehal <i>et al.</i>, “Persistent and reversible solid iodine electrodeposition in nanoporous carbons,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ista":"Prehal C, Fitzek H, Kothleitner G, Presser V, Gollas B, Freunberger SA, Abbas Q. 2020. Persistent and reversible solid iodine electrodeposition in nanoporous carbons. Nature Communications. 11, 4838.","chicago":"Prehal, Christian, Harald Fitzek, Gerald Kothleitner, Volker Presser, Bernhard Gollas, Stefan Alexander Freunberger, and Qamar Abbas. “Persistent and Reversible Solid Iodine Electrodeposition in Nanoporous Carbons.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18610-6\">https://doi.org/10.1038/s41467-020-18610-6</a>.","mla":"Prehal, Christian, et al. “Persistent and Reversible Solid Iodine Electrodeposition in Nanoporous Carbons.” <i>Nature Communications</i>, vol. 11, 4838, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18610-6\">10.1038/s41467-020-18610-6</a>.","apa":"Prehal, C., Fitzek, H., Kothleitner, G., Presser, V., Gollas, B., Freunberger, S. A., &#38; Abbas, Q. (2020). Persistent and reversible solid iodine electrodeposition in nanoporous carbons. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18610-6\">https://doi.org/10.1038/s41467-020-18610-6</a>","ama":"Prehal C, Fitzek H, Kothleitner G, et al. Persistent and reversible solid iodine electrodeposition in nanoporous carbons. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18610-6\">10.1038/s41467-020-18610-6</a>"},"type":"journal_article","ddc":["530"],"article_number":"4838","fulldoi":"https://doi.org/10.1038/s41467-020-18610-6","publisher":"Springer Nature","title":"Persistent and reversible solid iodine electrodeposition in nanoporous carbons","abstract":[{"lang":"eng","text":"Aqueous iodine based electrochemical energy storage is considered a potential candidate to improve sustainability and performance of current battery and supercapacitor technology. It harnesses the redox activity of iodide, iodine, and polyiodide species in the confined geometry of nanoporous carbon electrodes. However, current descriptions of the electrochemical reaction mechanism to interconvert these species are elusive. Here we show that electrochemical oxidation of iodide in nanoporous carbons forms persistent solid iodine deposits. Confinement slows down dissolution into triiodide and pentaiodide, responsible for otherwise significant self-discharge via shuttling. The main tools for these insights are in situ Raman spectroscopy and in situ small and wide-angle X-ray scattering (in situ SAXS/WAXS). In situ Raman confirms the reversible formation of triiodide and pentaiodide. In situ SAXS/WAXS indicates remarkable amounts of solid iodine deposited in the carbon nanopores. Combined with stochastic modeling, in situ SAXS allows quantifying the solid iodine volume fraction and visualizing the iodine structure on 3D lattice models at the sub-nanometer scale. Based on the derived mechanism, we demonstrate strategies for improved iodine pore filling capacity and prevention of self-discharge, applicable to hybrid supercapacitors and batteries."}],"has_accepted_license":"1","article_type":"original","article_processing_charge":"No","publication_status":"published","isi":1,"author":[{"full_name":"Prehal, Christian","last_name":"Prehal","first_name":"Christian"},{"first_name":"Harald","last_name":"Fitzek","full_name":"Fitzek, Harald"},{"last_name":"Kothleitner","first_name":"Gerald","full_name":"Kothleitner, Gerald"},{"first_name":"Volker","last_name":"Presser","full_name":"Presser, Volker"},{"full_name":"Gollas, Bernhard","first_name":"Bernhard","last_name":"Gollas"},{"id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","full_name":"Freunberger, Stefan Alexander","orcid":"0000-0003-2902-5319","last_name":"Freunberger","first_name":"Stefan Alexander"},{"full_name":"Abbas, Qamar","last_name":"Abbas","first_name":"Qamar"}],"scopus_import":"1","_id":"8568"},{"date_created":"2020-11-09T07:49:36Z","department":[{"_id":"EM-Fac"}],"citation":{"chicago":"Schulte, Linda, Jiafei Mao, Julian Reitz, Sridhar Sreeramulu, Denis Kudlinzki, Victor-Valentin Hodirnau, Jakob Meier-Credo, et al. “Cysteine Oxidation and Disulfide Formation in the Ribosomal Exit Tunnel.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-19372-x\">https://doi.org/10.1038/s41467-020-19372-x</a>.","apa":"Schulte, L., Mao, J., Reitz, J., Sreeramulu, S., Kudlinzki, D., Hodirnau, V.-V., … Schwalbe, H. (2020). Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-19372-x\">https://doi.org/10.1038/s41467-020-19372-x</a>","mla":"Schulte, Linda, et al. “Cysteine Oxidation and Disulfide Formation in the Ribosomal Exit Tunnel.” <i>Nature Communications</i>, vol. 11, 5569, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-19372-x\">10.1038/s41467-020-19372-x</a>.","ama":"Schulte L, Mao J, Reitz J, et al. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-19372-x\">10.1038/s41467-020-19372-x</a>","short":"L. Schulte, J. Mao, J. Reitz, S. Sreeramulu, D. Kudlinzki, V.-V. Hodirnau, J. Meier-Credo, K. Saxena, F. Buhr, J.D. Langer, M. Blackledge, A.S. Frangakis, C. Glaubitz, H. Schwalbe, Nature Communications 11 (2020).","ieee":"L. Schulte <i>et al.</i>, “Cysteine oxidation and disulfide formation in the ribosomal exit tunnel,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ista":"Schulte L, Mao J, Reitz J, Sreeramulu S, Kudlinzki D, Hodirnau V-V, Meier-Credo J, Saxena K, Buhr F, Langer JD, Blackledge M, Frangakis AS, Glaubitz C, Schwalbe H. 2020. Cysteine oxidation and disulfide formation in the ribosomal exit tunnel. Nature Communications. 11, 5569."},"volume":11,"oa_version":"Published Version","day":"04","doi":"10.1038/s41467-020-19372-x","month":"11","date_published":"2020-11-04T00:00:00Z","date_updated":"2025-06-12T07:01:22Z","oa":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","file_date_updated":"2020-11-09T07:56:24Z","publication_identifier":{"issn":["2041-1723"]},"intvolume":"        11","language":[{"iso":"eng"}],"file":[{"relation":"main_file","creator":"dernst","file_id":"8745","date_updated":"2020-11-09T07:56:24Z","file_size":1670898,"checksum":"b2688f0347e69e6629bba582077278c5","access_level":"open_access","date_created":"2020-11-09T07:56:24Z","content_type":"application/pdf","file_name":"2020_NatureComm_Schulte.pdf","success":1}],"year":"2020","external_id":{"pmid":["33149120"],"isi":["000592028600001"]},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Nature Communications","acknowledgement":"We acknowledge help from Anja Seybert, Margot Frangakis, Diana Grewe, Mikhail Eltsov, Utz Ermel, and Shintaro Aibara. The work was supported by Deutsche Forschungsgemeinschaft in the CLiC graduate school. Work at the Center for Biomolecular Magnetic Resonance (BMRZ) is supported by the German state of Hesse. The work at BMRZ has been supported by the state of Hesse. L.S. has been supported by the DFG graduate college: CLiC.","scopus_import":"1","_id":"8744","author":[{"full_name":"Schulte, Linda","last_name":"Schulte","first_name":"Linda"},{"full_name":"Mao, Jiafei","last_name":"Mao","first_name":"Jiafei"},{"first_name":"Julian","last_name":"Reitz","full_name":"Reitz, Julian"},{"full_name":"Sreeramulu, Sridhar","last_name":"Sreeramulu","first_name":"Sridhar"},{"full_name":"Kudlinzki, Denis","last_name":"Kudlinzki","first_name":"Denis"},{"id":"3661B498-F248-11E8-B48F-1D18A9856A87","full_name":"Hodirnau, Victor-Valentin","orcid":"0000-0003-3904-947X","first_name":"Victor-Valentin","last_name":"Hodirnau"},{"full_name":"Meier-Credo, Jakob","first_name":"Jakob","last_name":"Meier-Credo"},{"full_name":"Saxena, Krishna","first_name":"Krishna","last_name":"Saxena"},{"full_name":"Buhr, Florian","last_name":"Buhr","first_name":"Florian"},{"last_name":"Langer","first_name":"Julian D.","full_name":"Langer, Julian D."},{"last_name":"Blackledge","first_name":"Martin","full_name":"Blackledge, Martin"},{"last_name":"Frangakis","first_name":"Achilleas S.","full_name":"Frangakis, Achilleas S."},{"first_name":"Clemens","last_name":"Glaubitz","full_name":"Glaubitz, Clemens"},{"last_name":"Schwalbe","first_name":"Harald","full_name":"Schwalbe, Harald"}],"isi":1,"publication_status":"published","article_processing_charge":"No","title":"Cysteine oxidation and disulfide formation in the ribosomal exit tunnel","publisher":"Springer Nature","abstract":[{"lang":"eng","text":"Understanding the conformational sampling of translation-arrested ribosome nascent chain complexes is key to understand co-translational folding. Up to now, coupling of cysteine oxidation, disulfide bond formation and structure formation in nascent chains has remained elusive. Here, we investigate the eye-lens protein γB-crystallin in the ribosomal exit tunnel. Using mass spectrometry, theoretical simulations, dynamic nuclear polarization-enhanced solid-state nuclear magnetic resonance and cryo-electron microscopy, we show that thiol groups of cysteine residues undergo S-glutathionylation and S-nitrosylation and form non-native disulfide bonds. Thus, covalent modification chemistry occurs already prior to nascent chain release as the ribosome exit tunnel provides sufficient space even for disulfide bond formation which can guide protein folding."}],"article_type":"original","has_accepted_license":"1","type":"journal_article","article_number":"5569","ddc":["570"],"fulldoi":"https://doi.org/10.1038/s41467-020-19372-x"},{"article_number":"6437","ddc":["570"],"type":"journal_article","fulldoi":"https://doi.org/10.1038/s41467-020-20286-x","has_accepted_license":"1","article_type":"original","abstract":[{"text":"The actin-related protein (Arp)2/3 complex nucleates branched actin filament networks pivotal for cell migration, endocytosis and pathogen infection. Its activation is tightly regulated and involves complex structural rearrangements and actin filament binding, which are yet to be understood. Here, we report a 9.0 Å resolution structure of the actin filament Arp2/3 complex branch junction in cells using cryo-electron tomography and subtomogram averaging. This allows us to generate an accurate model of the active Arp2/3 complex in the branch junction and its interaction with actin filaments. Notably, our model reveals a previously undescribed set of interactions of the Arp2/3 complex with the mother filament, significantly different to the previous branch junction model. Our structure also indicates a central role for the ArpC3 subunit in stabilizing the active conformation.","lang":"eng"}],"publisher":"Springer Nature","title":"Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction","article_processing_charge":"No","publication_status":"published","isi":1,"author":[{"first_name":"Florian","last_name":"Fäßler","orcid":"0000-0001-7149-769X","full_name":"Fäßler, Florian","id":"404F5528-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Georgi A","last_name":"Dimchev","orcid":"0000-0001-8370-6161","full_name":"Dimchev, Georgi A","id":"38C393BE-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-3904-947X","first_name":"Victor-Valentin","last_name":"Hodirnau","id":"3661B498-F248-11E8-B48F-1D18A9856A87","full_name":"Hodirnau, Victor-Valentin"},{"full_name":"Wan, William","last_name":"Wan","first_name":"William"},{"orcid":"0000-0003-4790-8078","first_name":"Florian KM","last_name":"Schur","id":"48AD8942-F248-11E8-B48F-1D18A9856A87","full_name":"Schur, Florian KM"}],"acknowledgement":"This research was supported by the Scientific Service Units (SSUs) of IST Austria through resources provided by Scientific Computing (SciComp), the Life Science Facility (LSF), the BioImaging Facility (BIF), and the Electron Microscopy Facility (EMF). We also thank Dimitry Tegunov (MPI for Biophysical Chemistry) for helpful discussions\r\nabout the M software, and Michael Sixt (IST Austria) and Klemens Rottner (Technical University Braunschweig, HZI Braunschweig) for critical reading of the manuscript. We also thank Gregory Voth (University of Chicago) for providing us the MD-derived branch junction model for comparison. The authors acknowledge support from IST Austria and from the Austrian Science Fund (FWF): M02495 to G.D. and Austrian Science Fund (FWF): P33367 to F.K.M.S. ","_id":"8971","scopus_import":"1","external_id":{"isi":["000603078000003"]},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"publication":"Nature Communications","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/cutting-edge-technology-reveals-structures-within-cells/","relation":"press_release"}]},"year":"2020","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"publication_identifier":{"issn":["2041-1723"]},"file_date_updated":"2020-12-28T08:16:10Z","status":"public","file":[{"checksum":"55d43ea0061cc4027ba45e966e1db8cc","access_level":"open_access","date_created":"2020-12-28T08:16:10Z","content_type":"application/pdf","file_name":"2020_NatureComm_Faessler.pdf","success":1,"relation":"main_file","file_id":"8975","creator":"dernst","date_updated":"2020-12-28T08:16:10Z","file_size":3958727}],"language":[{"iso":"eng"}],"corr_author":"1","intvolume":"        11","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"date_published":"2020-12-22T00:00:00Z","month":"12","quality_controlled":"1","date_updated":"2025-04-15T07:52:12Z","oa":1,"project":[{"name":"Structure and isoform diversity of the Arp2/3 complex","_id":"9B954C5C-BA93-11EA-9121-9846C619BF3A","grant_number":"P33367"},{"_id":"2674F658-B435-11E9-9278-68D0E5697425","name":"Protein structure and function in filopodia across scales","grant_number":"M02495","call_identifier":"FWF"}],"day":"22","doi":"10.1038/s41467-020-20286-x","oa_version":"Published Version","volume":11,"department":[{"_id":"FlSc"},{"_id":"EM-Fac"}],"date_created":"2020-12-23T08:25:45Z","citation":{"ama":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>","apa":"Fäßler, F., Dimchev, G. A., Hodirnau, V.-V., Wan, W., &#38; Schur, F. K. (2020). Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>","mla":"Fäßler, Florian, et al. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>, vol. 11, 6437, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-20286-x\">10.1038/s41467-020-20286-x</a>.","chicago":"Fäßler, Florian, Georgi A Dimchev, Victor-Valentin Hodirnau, William Wan, and Florian KM Schur. “Cryo-Electron Tomography Structure of Arp2/3 Complex in Cells Reveals New Insights into the Branch Junction.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-20286-x\">https://doi.org/10.1038/s41467-020-20286-x</a>.","ista":"Fäßler F, Dimchev GA, Hodirnau V-V, Wan W, Schur FK. 2020. Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction. Nature Communications. 11, 6437.","ieee":"F. Fäßler, G. A. Dimchev, V.-V. Hodirnau, W. Wan, and F. K. Schur, “Cryo-electron tomography structure of Arp2/3 complex in cells reveals new insights into the branch junction,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","short":"F. Fäßler, G.A. Dimchev, V.-V. Hodirnau, W. Wan, F.K. Schur, Nature Communications 11 (2020)."}},{"year":"2020","related_material":{"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/new-function-for-potential-tumour-suppressor-in-brain-development/"}]},"acknowledged_ssus":[{"_id":"PreCl"}],"external_id":{"isi":["000551459000005"],"pmid":["31924768"]},"publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["2041-1723"]},"status":"public","file_date_updated":"2020-07-14T12:47:54Z","file":[{"access_level":"open_access","date_created":"2020-01-13T07:42:31Z","checksum":"ebf1ed522f4e0be8d94c939c1806a709","file_name":"2020_NatureComm_Laukoter.pdf","content_type":"application/pdf","relation":"main_file","file_size":8063333,"file_id":"7261","date_updated":"2020-07-14T12:47:54Z","creator":"dernst"}],"language":[{"iso":"eng"}],"corr_author":"1","intvolume":"        11","project":[{"name":"Role of Eed in neural stem cell lineage progression","_id":"268F8446-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"T01031"},{"name":"Molecular Mechanisms Regulating Gliogenesis in the Neocortex","_id":"264E56E2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","grant_number":"M02416"},{"name":"Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development","_id":"260018B0-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"725780"},{"_id":"25D92700-B435-11E9-9278-68D0E5697425","name":"Mapping Cell-Type Specificity of the Genomic Imprintome in the Brain","grant_number":"LS13-002"}],"day":"10","doi":"10.1038/s41467-019-14077-2","date_published":"2020-01-10T00:00:00Z","month":"01","quality_controlled":"1","oa":1,"date_updated":"2025-06-12T07:30:49Z","department":[{"_id":"SiHi"}],"date_created":"2020-01-11T10:42:48Z","citation":{"ama":"Laukoter S, Beattie RJ, Pauler F, Amberg N, Nakayama KI, Hippenmeyer S. Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-019-14077-2\">10.1038/s41467-019-14077-2</a>","chicago":"Laukoter, Susanne, Robert J Beattie, Florian Pauler, Nicole Amberg, Keiichi I. Nakayama, and Simon Hippenmeyer. “Imprinted Cdkn1c Genomic Locus Cell-Autonomously Promotes Cell Survival in Cerebral Cortex Development.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-019-14077-2\">https://doi.org/10.1038/s41467-019-14077-2</a>.","apa":"Laukoter, S., Beattie, R. J., Pauler, F., Amberg, N., Nakayama, K. I., &#38; Hippenmeyer, S. (2020). Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-14077-2\">https://doi.org/10.1038/s41467-019-14077-2</a>","mla":"Laukoter, Susanne, et al. “Imprinted Cdkn1c Genomic Locus Cell-Autonomously Promotes Cell Survival in Cerebral Cortex Development.” <i>Nature Communications</i>, vol. 11, 195, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-019-14077-2\">10.1038/s41467-019-14077-2</a>.","ista":"Laukoter S, Beattie RJ, Pauler F, Amberg N, Nakayama KI, Hippenmeyer S. 2020. Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development. Nature Communications. 11, 195.","short":"S. Laukoter, R.J. Beattie, F. Pauler, N. Amberg, K.I. Nakayama, S. Hippenmeyer, Nature Communications 11 (2020).","ieee":"S. Laukoter, R. J. Beattie, F. Pauler, N. Amberg, K. I. Nakayama, and S. Hippenmeyer, “Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020."},"oa_version":"Published Version","volume":11,"article_type":"original","has_accepted_license":"1","abstract":[{"text":"The cyclin-dependent kinase inhibitor p57KIP2 is encoded by the imprinted Cdkn1c locus, exhibits maternal expression, and is essential for cerebral cortex development. How Cdkn1c regulates corticogenesis is however not clear. To this end we employ Mosaic Analysis with Double Markers (MADM) technology to genetically dissect Cdkn1c gene function in corticogenesis at single cell resolution. We find that the previously described growth-inhibitory Cdkn1c function is a non-cell-autonomous one, acting on the whole organism. In contrast we reveal a growth-promoting cell-autonomous Cdkn1c function which at the mechanistic level mediates radial glial progenitor cell and nascent projection neuron survival. Strikingly, the growth-promoting function of Cdkn1c is highly dosage sensitive but not subject to genomic imprinting. Collectively, our results suggest that the Cdkn1c locus regulates cortical development through distinct cell-autonomous and non-cell-autonomous mechanisms. More generally, our study highlights the importance to probe the relative contributions of cell intrinsic gene function and tissue-wide mechanisms to the overall phenotype.","lang":"eng"}],"title":"Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development","publisher":"Springer Nature","article_number":"195","ddc":["570"],"type":"journal_article","fulldoi":"https://doi.org/10.1038/s41467-019-14077-2","article_processing_charge":"No","ec_funded":1,"isi":1,"publication_status":"published","_id":"7253","scopus_import":"1","author":[{"full_name":"Laukoter, Susanne","id":"2D6B7A9A-F248-11E8-B48F-1D18A9856A87","first_name":"Susanne","last_name":"Laukoter","orcid":"0000-0002-7903-3010"},{"first_name":"Robert J","last_name":"Beattie","orcid":"0000-0002-8483-8753","full_name":"Beattie, Robert J","id":"2E26DF60-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-7462-0048","last_name":"Pauler","first_name":"Florian","id":"48EA0138-F248-11E8-B48F-1D18A9856A87","full_name":"Pauler, Florian"},{"orcid":"0000-0002-3183-8207","last_name":"Amberg","first_name":"Nicole","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","full_name":"Amberg, Nicole"},{"full_name":"Nakayama, Keiichi I.","first_name":"Keiichi I.","last_name":"Nakayama"},{"id":"37B36620-F248-11E8-B48F-1D18A9856A87","full_name":"Hippenmeyer, Simon","orcid":"0000-0003-2279-1061","first_name":"Simon","last_name":"Hippenmeyer"}]},{"ec_funded":1,"isi":1,"publication_status":"published","scopus_import":"1","_id":"7262","author":[{"full_name":"Guseinov, Ruslan","id":"3AB45EE2-F248-11E8-B48F-1D18A9856A87","last_name":"Guseinov","first_name":"Ruslan","orcid":"0000-0001-9819-5077"},{"last_name":"McMahan","first_name":"Connor","full_name":"McMahan, Connor"},{"id":"2DC83906-F248-11E8-B48F-1D18A9856A87","full_name":"Perez Rodriguez, Jesus","last_name":"Perez Rodriguez","first_name":"Jesus"},{"last_name":"Daraio","first_name":"Chiara","full_name":"Daraio, Chiara"},{"id":"49876194-F248-11E8-B48F-1D18A9856A87","full_name":"Bickel, Bernd","orcid":"0000-0001-6511-9385","last_name":"Bickel","first_name":"Bernd"}],"title":"Programming temporal morphing of self-actuated shells","publisher":"Springer Nature","abstract":[{"lang":"eng","text":"Advances in shape-morphing materials, such as hydrogels, shape-memory polymers and light-responsive polymers have enabled prescribing self-directed deformations of initially flat geometries. However, most proposed solutions evolve towards a target geometry without considering time-dependent actuation paths. To achieve more complex geometries and avoid self-collisions, it is critical to encode a spatial and temporal shape evolution within the initially flat shell. Recent realizations of time-dependent morphing are limited to the actuation of few, discrete hinges and cannot form doubly curved surfaces. Here, we demonstrate a method for encoding temporal shape evolution in architected shells that assume complex shapes and doubly curved geometries. The shells are non-periodic tessellations of pre-stressed contractile unit cells that soften in water at rates prescribed locally by mesostructure geometry. The ensuing midplane contraction is coupled to the formation of encoded curvatures. We propose an inverse design tool based on a data-driven model for unit cells’ temporal responses."}],"article_type":"original","has_accepted_license":"1","type":"journal_article","article_number":"237","ddc":["000"],"fulldoi":"https://doi.org/10.1038/s41467-019-14015-2","article_processing_charge":"No","project":[{"call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"},{"call_identifier":"H2020","grant_number":"715767","_id":"24F9549A-B435-11E9-9278-68D0E5697425","name":"MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and Modeling"}],"day":"13","doi":"10.1038/s41467-019-14015-2","month":"01","date_published":"2020-01-13T00:00:00Z","date_updated":"2026-04-08T07:25:22Z","oa":1,"quality_controlled":"1","date_created":"2020-01-13T16:54:26Z","department":[{"_id":"BeBi"}],"citation":{"short":"R. Guseinov, C. McMahan, J. Perez Rodriguez, C. Daraio, B. Bickel, Nature Communications 11 (2020).","ieee":"R. Guseinov, C. McMahan, J. Perez Rodriguez, C. Daraio, and B. Bickel, “Programming temporal morphing of self-actuated shells,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ista":"Guseinov R, McMahan C, Perez Rodriguez J, Daraio C, Bickel B. 2020. Programming temporal morphing of self-actuated shells. Nature Communications. 11, 237.","chicago":"Guseinov, Ruslan, Connor McMahan, Jesus Perez Rodriguez, Chiara Daraio, and Bernd Bickel. “Programming Temporal Morphing of Self-Actuated Shells.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-019-14015-2\">https://doi.org/10.1038/s41467-019-14015-2</a>.","apa":"Guseinov, R., McMahan, C., Perez Rodriguez, J., Daraio, C., &#38; Bickel, B. (2020). Programming temporal morphing of self-actuated shells. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-14015-2\">https://doi.org/10.1038/s41467-019-14015-2</a>","mla":"Guseinov, Ruslan, et al. “Programming Temporal Morphing of Self-Actuated Shells.” <i>Nature Communications</i>, vol. 11, 237, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-019-14015-2\">10.1038/s41467-019-14015-2</a>.","ama":"Guseinov R, McMahan C, Perez Rodriguez J, Daraio C, Bickel B. Programming temporal morphing of self-actuated shells. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-019-14015-2\">10.1038/s41467-019-14015-2</a>"},"volume":11,"oa_version":"Published Version","year":"2020","related_material":{"record":[{"status":"public","relation":"research_data","id":"7154"},{"id":"8366","relation":"dissertation_contains","status":"public"}],"link":[{"relation":"press_release","description":"News on IST Homepage","url":"https://ist.ac.at/en/news/geometry-meets-time/"}]},"keyword":["Design","Synthesis and processing","Mechanical engineering","Polymers"],"external_id":{"pmid":["31932589"],"isi":["000511916800015"]},"pmid":1,"publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"status":"public","file_date_updated":"2020-07-14T12:47:55Z","publication_identifier":{"issn":["2041-1723"]},"intvolume":"        11","file":[{"file_name":"2020_NatureComm_Guseinov.pdf","content_type":"application/pdf","checksum":"7db23fef2f4cda712f17f1004116ddff","date_created":"2020-01-15T14:35:34Z","access_level":"open_access","file_id":"7336","creator":"rguseino","date_updated":"2020-07-14T12:47:55Z","file_size":1315270,"relation":"main_file"}],"language":[{"iso":"eng"}],"corr_author":"1"},{"scopus_import":"1","_id":"8529","acknowledgement":"We thank Yuan Chen for performing supplementary FEM simulations and Andrew Higginbotham, Ralf Riedinger, Sungkun Hong, and Lorenzo Magrini for valuable discussions. This work was supported by IST Austria, the IST nanofabrication facility (NFF), the European Union’s Horizon 2020 research and innovation program under grant agreement no. 732894 (FET Proactive HOT) and the European Research Council under grant agreement no. 758053 (ERC StG QUNNECT). G.A. is the recipient of a DOC fellowship of the Austrian Academy of Sciences at IST Austria. W.H. is the recipient of an ISTplus postdoctoral fellowship with funding from the European Union’s Horizon 2020 research and innovation program under the Marie Sklodowska-Curie grant agreement no. 754411. J.M.F. acknowledges support from the Austrian Science Fund (FWF) through BeyondC (F71), a NOMIS foundation research grant, and the EU’s Horizon 2020 research and innovation program under grant agreement no. 862644 (FET Open QUARTET).","author":[{"id":"3770C838-F248-11E8-B48F-1D18A9856A87","full_name":"Arnold, Georg M","orcid":"0000-0003-1397-7876","first_name":"Georg M","last_name":"Arnold"},{"id":"45598606-F248-11E8-B48F-1D18A9856A87","full_name":"Wulf, Matthias","orcid":"0000-0001-6613-1378","first_name":"Matthias","last_name":"Wulf"},{"id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","full_name":"Barzanjeh, Shabir","orcid":"0000-0003-0415-1423","last_name":"Barzanjeh","first_name":"Shabir"},{"first_name":"Elena","last_name":"Redchenko","id":"2C21D6E8-F248-11E8-B48F-1D18A9856A87","full_name":"Redchenko, Elena"},{"full_name":"Rueda Sanchez, Alfredo R","id":"3B82B0F8-F248-11E8-B48F-1D18A9856A87","last_name":"Rueda Sanchez","first_name":"Alfredo R","orcid":"0000-0001-6249-5860"},{"orcid":"0000-0001-9868-2166","last_name":"Hease","first_name":"William J","id":"29705398-F248-11E8-B48F-1D18A9856A87","full_name":"Hease, William J"},{"full_name":"Hassani, Farid","id":"2AED110C-F248-11E8-B48F-1D18A9856A87","last_name":"Hassani","first_name":"Farid","orcid":"0000-0001-6937-5773"},{"first_name":"Johannes M","last_name":"Fink","orcid":"0000-0001-8112-028X","full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87"}],"isi":1,"ec_funded":1,"publication_status":"published","article_processing_charge":"No","has_accepted_license":"1","article_type":"original","title":"Converting microwave and telecom photons with a silicon photonic nanomechanical interface","publisher":"Springer Nature","abstract":[{"lang":"eng","text":"Practical quantum networks require low-loss and noise-resilient optical interconnects as well as non-Gaussian resources for entanglement distillation and distributed quantum computation. The latter could be provided by superconducting circuits but existing solutions to interface the microwave and optical domains lack either scalability or efficiency, and in most cases the conversion noise is not known. In this work we utilize the unique opportunities of silicon photonics, cavity optomechanics and superconducting circuits to demonstrate a fully integrated, coherent transducer interfacing the microwave X and the telecom S bands with a total (internal) bidirectional transduction efficiency of 1.2% (135%) at millikelvin temperatures. The coupling relies solely on the radiation pressure interaction mediated by the femtometer-scale motion of two silicon nanobeams reaching a <jats:italic>V</jats:italic><jats:sub><jats:italic>π</jats:italic></jats:sub> as low as 16 μV for sub-nanowatt pump powers. Without the associated optomechanical gain, we achieve a total (internal) pure conversion efficiency of up to 0.019% (1.6%), relevant for future noise-free operation on this qubit-compatible platform."}],"fulldoi":"https://doi.org/10.1038/s41467-020-18269-z","article_number":"4460","ddc":["530"],"type":"journal_article","citation":{"ista":"Arnold GM, Wulf M, Barzanjeh S, Redchenko E, Rueda Sanchez AR, Hease WJ, Hassani F, Fink JM. 2020. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. Nature Communications. 11, 4460.","short":"G.M. Arnold, M. Wulf, S. Barzanjeh, E. Redchenko, A.R. Rueda Sanchez, W.J. Hease, F. Hassani, J.M. Fink, Nature Communications 11 (2020).","ieee":"G. M. Arnold <i>et al.</i>, “Converting microwave and telecom photons with a silicon photonic nanomechanical interface,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","ama":"Arnold GM, Wulf M, Barzanjeh S, et al. Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>","chicago":"Arnold, Georg M, Matthias Wulf, Shabir Barzanjeh, Elena Redchenko, Alfredo R Rueda Sanchez, William J Hease, Farid Hassani, and Johannes M Fink. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>.","mla":"Arnold, Georg M., et al. “Converting Microwave and Telecom Photons with a Silicon Photonic Nanomechanical Interface.” <i>Nature Communications</i>, vol. 11, 4460, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-18269-z\">10.1038/s41467-020-18269-z</a>.","apa":"Arnold, G. M., Wulf, M., Barzanjeh, S., Redchenko, E., Rueda Sanchez, A. R., Hease, W. J., … Fink, J. M. (2020). Converting microwave and telecom photons with a silicon photonic nanomechanical interface. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-18269-z\">https://doi.org/10.1038/s41467-020-18269-z</a>"},"department":[{"_id":"JoFi"}],"date_created":"2020-09-18T10:56:20Z","oa_version":"Published Version","volume":11,"doi":"10.1038/s41467-020-18269-z","project":[{"name":"Hybrid Optomechanical Technologies","_id":"257EB838-B435-11E9-9278-68D0E5697425","grant_number":"732894","call_identifier":"H2020"},{"name":"A Fiber Optic Transceiver for Superconducting Qubits","_id":"26336814-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"758053"},{"grant_number":"754411","call_identifier":"H2020","name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425"},{"name":"Quantum readout techniques and technologies","_id":"237CBA6C-32DE-11EA-91FC-C7463DDC885E","call_identifier":"H2020","grant_number":"862644"},{"name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies","_id":"2671EB66-B435-11E9-9278-68D0E5697425"}],"day":"08","quality_controlled":"1","oa":1,"date_updated":"2026-11-13T23:30:29Z","date_published":"2020-09-08T00:00:00Z","month":"09","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"corr_author":"1","language":[{"iso":"eng"}],"file":[{"file_id":"8530","date_updated":"2020-09-18T13:02:37Z","creator":"dernst","file_size":1002818,"relation":"main_file","content_type":"application/pdf","file_name":"2020_NatureComm_Arnold.pdf","success":1,"checksum":"88f92544889eb18bb38e25629a422a86","access_level":"open_access","date_created":"2020-09-18T13:02:37Z"}],"intvolume":"        11","publication_identifier":{"issn":["2041-1723"]},"file_date_updated":"2020-09-18T13:02:37Z","status":"public","related_material":{"link":[{"relation":"erratum","url":"https://doi.org/10.1038/s41467-020-18912-9"},{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/how-to-transport-microwave-quantum-information-via-optical-fiber/","relation":"press_release"}],"record":[{"status":"public","relation":"research_data","id":"13056"},{"id":"18871","relation":"dissertation_contains","status":"public"}]},"year":"2020","acknowledged_ssus":[{"_id":"NanoFab"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Nature Communications","pmid":1,"external_id":{"isi":["000577280200001"],"pmid":["32901014"]},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"]},{"author":[{"id":"350F91D2-F248-11E8-B48F-1D18A9856A87","full_name":"Kavcic, Bor","orcid":"0000-0001-6041-254X","last_name":"Kavcic","first_name":"Bor"},{"orcid":"0000-0002-6699-1455","first_name":"Gašper","last_name":"Tkačik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","full_name":"Tkačik, Gašper"},{"full_name":"Bollenbach, Tobias","id":"3E6DB97A-F248-11E8-B48F-1D18A9856A87","last_name":"Bollenbach","first_name":"Tobias","orcid":"0000-0003-4398-476X"}],"_id":"8250","scopus_import":"1","acknowledgement":"We thank M. Hennessey-Wesen, I. Tomanek, K. Jain, A. Staron, K. Tomasek, M. Scott,\r\nK.C. Huang, and Z. Gitai for reading the manuscript and constructive comments. B.K. is\r\nindebted to C. Guet for additional guidance and generous support, which rendered this\r\nwork possible. B.K. thanks all members of Guet group for many helpful discussions and\r\nsharing of resources. B.K. additionally acknowledges the tremendous support from A.\r\nAngermayr and K. Mitosch with experimental work. We further thank E. Brown for\r\nhelpful comments regarding lamotrigine, and A. Buskirk for valuable suggestions\r\nregarding the ribosome footprint size. This work was supported in part by Austrian\r\nScience Fund (FWF) standalone grants P 27201-B22 (to T.B.) and P 28844 (to G.T.),\r\nHFSP program Grant RGP0042/2013 (to T.B.), German Research Foundation (DFG)\r\nstandalone grant BO 3502/2-1 (to T.B.), and German Research Foundation (DFG)\r\nCollaborative Research Centre (SFB) 1310 (to T.B.). Open access funding provided by\r\nProjekt DEAL.","publication_status":"published","isi":1,"article_processing_charge":"No","fulldoi":"https://doi.org/10.1038/s41467-020-17734-z","type":"journal_article","ddc":["570"],"article_number":"4013","publisher":"Springer Nature","title":"Mechanisms of drug interactions between translation-inhibiting antibiotics","abstract":[{"text":"Antibiotics that interfere with translation, when combined, interact in diverse and difficult-to-predict ways. Here, we explain these interactions by “translation bottlenecks”: points in the translation cycle where antibiotics block ribosomal progression. To elucidate the underlying mechanisms of drug interactions between translation inhibitors, we generate translation bottlenecks genetically using inducible control of translation factors that regulate well-defined translation cycle steps. These perturbations accurately mimic antibiotic action and drug interactions, supporting that the interplay of different translation bottlenecks causes these interactions. We further show that growth laws, combined with drug uptake and binding kinetics, enable the direct prediction of a large fraction of observed interactions, yet fail to predict suppression. However, varying two translation bottlenecks simultaneously supports that dense traffic of ribosomes and competition for translation factors account for the previously unexplained suppression. These results highlight the importance of “continuous epistasis” in bacterial physiology.","lang":"eng"}],"has_accepted_license":"1","article_type":"original","volume":11,"oa_version":"Published Version","citation":{"ieee":"B. Kavcic, G. Tkačik, and M. T. Bollenbach, “Mechanisms of drug interactions between translation-inhibiting antibiotics,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.","short":"B. Kavcic, G. Tkačik, M.T. Bollenbach, Nature Communications 11 (2020).","ista":"Kavcic B, Tkačik G, Bollenbach MT. 2020. Mechanisms of drug interactions between translation-inhibiting antibiotics. Nature Communications. 11, 4013.","mla":"Kavcic, Bor, et al. “Mechanisms of Drug Interactions between Translation-Inhibiting Antibiotics.” <i>Nature Communications</i>, vol. 11, 4013, Springer Nature, 2020, doi:<a href=\"https://doi.org/10.1038/s41467-020-17734-z\">10.1038/s41467-020-17734-z</a>.","apa":"Kavcic, B., Tkačik, G., &#38; Bollenbach, M. T. (2020). Mechanisms of drug interactions between translation-inhibiting antibiotics. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-020-17734-z\">https://doi.org/10.1038/s41467-020-17734-z</a>","chicago":"Kavcic, Bor, Gašper Tkačik, and Mark Tobias Bollenbach. “Mechanisms of Drug Interactions between Translation-Inhibiting Antibiotics.” <i>Nature Communications</i>. Springer Nature, 2020. <a href=\"https://doi.org/10.1038/s41467-020-17734-z\">https://doi.org/10.1038/s41467-020-17734-z</a>.","ama":"Kavcic B, Tkačik G, Bollenbach MT. Mechanisms of drug interactions between translation-inhibiting antibiotics. <i>Nature Communications</i>. 2020;11. doi:<a href=\"https://doi.org/10.1038/s41467-020-17734-z\">10.1038/s41467-020-17734-z</a>"},"date_created":"2020-08-12T09:13:50Z","department":[{"_id":"GaTk"}],"oa":1,"date_updated":"2026-11-13T23:30:46Z","quality_controlled":"1","month":"08","date_published":"2020-08-11T00:00:00Z","doi":"10.1038/s41467-020-17734-z","project":[{"grant_number":"P27201-B22","call_identifier":"FWF","_id":"25E9AF9E-B435-11E9-9278-68D0E5697425","name":"Revealing the mechanisms underlying drug interactions"},{"name":"Biophysics of information processing in gene regulation","_id":"254E9036-B435-11E9-9278-68D0E5697425","grant_number":"P28844-B27","call_identifier":"FWF"}],"day":"11","intvolume":"        11","language":[{"iso":"eng"}],"file":[{"relation":"main_file","date_updated":"2020-08-17T07:36:57Z","file_id":"8275","creator":"dernst","file_size":1965672,"checksum":"986bebb308850a55850028d3d2b5b664","access_level":"open_access","date_created":"2020-08-17T07:36:57Z","content_type":"application/pdf","file_name":"2020_NatureComm_Kavcic.pdf","success":1}],"file_date_updated":"2020-08-17T07:36:57Z","status":"public","publication_identifier":{"issn":["2041-1723"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"pmid":1,"publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"isi":["000562769300008"],"pmid":["32782250"]},"related_material":{"record":[{"status":"public","id":"8657","relation":"dissertation_contains"}]},"year":"2020"},{"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"intvolume":"        10","corr_author":"1","language":[{"iso":"eng"}],"file":[{"relation":"main_file","file_size":1331490,"creator":"dernst","date_updated":"2020-07-14T12:47:17Z","file_id":"6015","date_created":"2019-02-15T07:15:00Z","access_level":"open_access","checksum":"d3acf07eaad95ec040d8e8565fc9ac37","file_name":"2019_NatureComm_Varshney.pdf","content_type":"application/pdf"}],"status":"public","file_date_updated":"2020-07-14T12:47:17Z","publication_identifier":{"issn":["2041-1723"]},"year":"2019","pmid":1,"publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","external_id":{"pmid":["30737403"],"arxiv":["1902.03763"],"isi":["000458175300001"]},"citation":{"ieee":"A. Varshney and V. Steinberg, “Elastic alfven waves in elastic turbulence,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","short":"A. Varshney, V. Steinberg, Nature Communications 10 (2019).","ista":"Varshney A, Steinberg V. 2019. Elastic alfven waves in elastic turbulence. Nature Communications. 10, 652.","apa":"Varshney, A., &#38; Steinberg, V. (2019). Elastic alfven waves in elastic turbulence. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-08551-0\">https://doi.org/10.1038/s41467-019-08551-0</a>","mla":"Varshney, Atul, and Victor Steinberg. “Elastic Alfven Waves in Elastic Turbulence.” <i>Nature Communications</i>, vol. 10, 652, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-08551-0\">10.1038/s41467-019-08551-0</a>.","chicago":"Varshney, Atul, and Victor Steinberg. “Elastic Alfven Waves in Elastic Turbulence.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-08551-0\">https://doi.org/10.1038/s41467-019-08551-0</a>.","ama":"Varshney A, Steinberg V. Elastic alfven waves in elastic turbulence. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-08551-0\">10.1038/s41467-019-08551-0</a>"},"date_created":"2019-02-15T07:10:46Z","department":[{"_id":"BjHo"}],"volume":10,"oa_version":"Published Version","doi":"10.1038/s41467-019-08551-0","project":[{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411"}],"day":"08","oa":1,"date_updated":"2025-04-14T07:43:46Z","quality_controlled":"1","month":"02","date_published":"2019-02-08T00:00:00Z","article_processing_charge":"No","abstract":[{"lang":"eng","text":"Speed of sound waves in gases and liquids are governed by the compressibility of the medium. There exists another type of non-dispersive wave where the wave speed depends on stress instead of elasticity of the medium. A well-known example is the Alfven wave, which propagates through plasma permeated by a magnetic field with the speed determined by magnetic tension. An elastic analogue of Alfven waves has been predicted in a flow of dilute polymer solution where the elastic stress of the stretching polymers determines the elastic wave speed. Here we present quantitative evidence of elastic Alfven waves in elastic turbulence of a viscoelastic creeping flow between two obstacles in channel flow. The key finding in the experimental proof is a nonlinear dependence of the elastic wave speed cel on the Weissenberg number Wi, which deviates from predictions based on a model of linear polymer elasticity."}],"title":"Elastic alfven waves in elastic turbulence","publisher":"Springer Nature","has_accepted_license":"1","article_type":"original","fulldoi":"https://doi.org/10.1038/s41467-019-08551-0","type":"journal_article","ddc":["530"],"arxiv":1,"article_number":"652","scopus_import":"1","_id":"6014","author":[{"orcid":"0000-0002-3072-5999","first_name":"Atul","last_name":"Varshney","id":"2A2006B2-F248-11E8-B48F-1D18A9856A87","full_name":"Varshney, Atul"},{"full_name":"Steinberg, Victor","first_name":"Victor","last_name":"Steinberg"}],"isi":1,"ec_funded":1,"publication_status":"published"},{"abstract":[{"text":"Electron transport in two-dimensional conducting materials such as graphene, with dominant electron–electron interaction, exhibits unusual vortex flow that leads to a nonlocal current-field relation (negative resistance), distinct from the classical Ohm’s law. The transport behavior of these materials is best described by low Reynolds number hydrodynamics, where the constitutive pressure–speed relation is Stoke’s law. Here we report evidence of such vortices observed in a viscous flow of Newtonian fluid in a microfluidic device consisting of a rectangular cavity—analogous to the electronic system. We extend our experimental observations to elliptic cavities of different eccentricities, and validate them by numerically solving bi-harmonic equation obtained for the viscous flow with no-slip boundary conditions. We verify the existence of a  predicted threshold at which vortices appear. Strikingly, we find that a two-dimensional theoretical model captures the essential features of three-dimensional Stokes flow in experiments.","lang":"eng"}],"publisher":"Springer Nature","title":"Stokes flow analogous to viscous electron current in graphene","has_accepted_license":"1","fulldoi":"https://doi.org/10.1038/s41467-019-08916-5","type":"journal_article","article_number":"937","ddc":["530","532"],"article_processing_charge":"No","isi":1,"ec_funded":1,"publication_status":"published","_id":"6069","scopus_import":"1","author":[{"last_name":"Mayzel","first_name":"Jonathan","full_name":"Mayzel, Jonathan"},{"full_name":"Steinberg, Victor","first_name":"Victor","last_name":"Steinberg"},{"id":"2A2006B2-F248-11E8-B48F-1D18A9856A87","full_name":"Varshney, Atul","orcid":"0000-0002-3072-5999","last_name":"Varshney","first_name":"Atul"}],"year":"2019","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication":"Nature Communications","external_id":{"isi":["000459704600001"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"intvolume":"        10","file":[{"checksum":"61192fc49e0d44907c2a4fe384e4b97f","access_level":"open_access","date_created":"2019-03-05T13:33:04Z","content_type":"application/pdf","file_name":"2019_NatureComm_Mayzel.pdf","relation":"main_file","date_updated":"2020-07-14T12:47:18Z","file_id":"6070","creator":"dernst","file_size":2646391}],"corr_author":"1","language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:18Z","status":"public","publication_identifier":{"issn":["2041-1723"]},"doi":"10.1038/s41467-019-08916-5","day":"26","project":[{"call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships"}],"oa":1,"date_updated":"2025-04-14T07:44:00Z","quality_controlled":"1","month":"02","date_published":"2019-02-26T00:00:00Z","citation":{"mla":"Mayzel, Jonathan, et al. “Stokes Flow Analogous to Viscous Electron Current in Graphene.” <i>Nature Communications</i>, vol. 10, 937, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-08916-5\">10.1038/s41467-019-08916-5</a>.","apa":"Mayzel, J., Steinberg, V., &#38; Varshney, A. (2019). Stokes flow analogous to viscous electron current in graphene. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-08916-5\">https://doi.org/10.1038/s41467-019-08916-5</a>","chicago":"Mayzel, Jonathan, Victor Steinberg, and Atul Varshney. “Stokes Flow Analogous to Viscous Electron Current in Graphene.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-08916-5\">https://doi.org/10.1038/s41467-019-08916-5</a>.","ama":"Mayzel J, Steinberg V, Varshney A. Stokes flow analogous to viscous electron current in graphene. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-08916-5\">10.1038/s41467-019-08916-5</a>","ieee":"J. Mayzel, V. Steinberg, and A. Varshney, “Stokes flow analogous to viscous electron current in graphene,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","short":"J. Mayzel, V. Steinberg, A. Varshney, Nature Communications 10 (2019).","ista":"Mayzel J, Steinberg V, Varshney A. 2019. Stokes flow analogous to viscous electron current in graphene. Nature Communications. 10, 937."},"date_created":"2019-03-05T13:18:30Z","department":[{"_id":"BjHo"}],"volume":10,"oa_version":"Published Version"},{"publication_status":"published","author":[{"full_name":"Delaneau, Olivier","last_name":"Delaneau","first_name":"Olivier"},{"full_name":"Zagury, Jean-François","last_name":"Zagury","first_name":"Jean-François"},{"last_name":"Robinson","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813","full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425"},{"full_name":"Marchini, Jonathan L.","last_name":"Marchini","first_name":"Jonathan L."},{"full_name":"Dermitzakis, Emmanouil T.","first_name":"Emmanouil T.","last_name":"Dermitzakis"}],"_id":"7710","fulldoi":"https://doi.org/10.1038/s41467-019-13225-y","type":"journal_article","article_number":"5436","title":"Accurate, scalable and integrative haplotype estimation","publisher":"Springer Nature","abstract":[{"lang":"eng","text":"The number of human genomes being genotyped or sequenced increases exponentially and efficient haplotype estimation methods able to handle this amount of data are now required. Here we present a method, SHAPEIT4, which substantially improves upon other methods to process large genotype and high coverage sequencing datasets. It notably exhibits sub-linear running times with sample size, provides highly accurate haplotypes and allows integrating external phasing information such as large reference panels of haplotypes, collections of pre-phased variants and long sequencing reads. We provide SHAPEIT4 in an open source format and demonstrate its performance in terms of accuracy and running times on two gold standard datasets: the UK Biobank data and the Genome In A Bottle."}],"article_type":"original","article_processing_charge":"No","date_updated":"2021-01-12T08:15:01Z","oa":1,"quality_controlled":"1","month":"11","date_published":"2019-11-28T00:00:00Z","doi":"10.1038/s41467-019-13225-y","day":"28","volume":10,"oa_version":"Published Version","citation":{"short":"O. Delaneau, J.-F. Zagury, M.R. Robinson, J.L. Marchini, E.T. Dermitzakis, Nature Communications 10 (2019).","ieee":"O. Delaneau, J.-F. Zagury, M. R. Robinson, J. L. Marchini, and E. T. Dermitzakis, “Accurate, scalable and integrative haplotype estimation,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","ista":"Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. 2019. Accurate, scalable and integrative haplotype estimation. Nature Communications. 10, 5436.","chicago":"Delaneau, Olivier, Jean-François Zagury, Matthew Richard Robinson, Jonathan L. Marchini, and Emmanouil T. Dermitzakis. “Accurate, Scalable and Integrative Haplotype Estimation.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-13225-y\">https://doi.org/10.1038/s41467-019-13225-y</a>.","apa":"Delaneau, O., Zagury, J.-F., Robinson, M. R., Marchini, J. L., &#38; Dermitzakis, E. T. (2019). Accurate, scalable and integrative haplotype estimation. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-13225-y\">https://doi.org/10.1038/s41467-019-13225-y</a>","mla":"Delaneau, Olivier, et al. “Accurate, Scalable and Integrative Haplotype Estimation.” <i>Nature Communications</i>, vol. 10, 5436, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-13225-y\">10.1038/s41467-019-13225-y</a>.","ama":"Delaneau O, Zagury J-F, Robinson MR, Marchini JL, Dermitzakis ET. Accurate, scalable and integrative haplotype estimation. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-13225-y\">10.1038/s41467-019-13225-y</a>"},"date_created":"2020-04-30T10:40:32Z","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41467-019-13225-y"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Nature Communications","extern":"1","year":"2019","intvolume":"        10","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"issn":["2041-1723"]}},{"day":"19","doi":"10.1038/s41467-019-10490-9","date_published":"2019-06-19T00:00:00Z","month":"06","quality_controlled":"1","oa":1,"date_updated":"2021-01-12T08:19:03Z","main_file_link":[{"url":"https://doi.org/10.1038/s41467-019-10490-9","open_access":"1"}],"date_created":"2020-09-17T10:28:25Z","citation":{"ama":"Gauto DF, Estrozi LF, Schwieters CD, et al. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-10490-9\">10.1038/s41467-019-10490-9</a>","mla":"Gauto, Diego F., et al. “Integrated NMR and Cryo-EM Atomic-Resolution Structure Determination of a Half-Megadalton Enzyme Complex.” <i>Nature Communications</i>, vol. 10, 2697, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-10490-9\">10.1038/s41467-019-10490-9</a>.","apa":"Gauto, D. F., Estrozi, L. F., Schwieters, C. D., Effantin, G., Macek, P., Sounier, R., … Boisbouvier, J. (2019). Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-10490-9\">https://doi.org/10.1038/s41467-019-10490-9</a>","chicago":"Gauto, Diego F., Leandro F. Estrozi, Charles D. Schwieters, Gregory Effantin, Pavel Macek, Remy Sounier, Astrid C. Sivertsen, et al. “Integrated NMR and Cryo-EM Atomic-Resolution Structure Determination of a Half-Megadalton Enzyme Complex.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-10490-9\">https://doi.org/10.1038/s41467-019-10490-9</a>.","ista":"Gauto DF, Estrozi LF, Schwieters CD, Effantin G, Macek P, Sounier R, Sivertsen AC, Schmidt E, Kerfah R, Mas G, Colletier J-P, Güntert P, Favier A, Schoehn G, Schanda P, Boisbouvier J. 2019. Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex. Nature Communications. 10, 2697.","ieee":"D. F. Gauto <i>et al.</i>, “Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","short":"D.F. Gauto, L.F. Estrozi, C.D. Schwieters, G. Effantin, P. Macek, R. Sounier, A.C. Sivertsen, E. Schmidt, R. Kerfah, G. Mas, J.-P. Colletier, P. Güntert, A. Favier, G. Schoehn, P. Schanda, J. Boisbouvier, Nature Communications 10 (2019)."},"oa_version":"Published Version","volume":10,"year":"2019","extern":"1","keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"external_id":{"pmid":["31217444"]},"publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","pmid":1,"publication_identifier":{"issn":["2041-1723"]},"status":"public","language":[{"iso":"eng"}],"intvolume":"        10","publication_status":"published","_id":"8405","author":[{"last_name":"Gauto","first_name":"Diego F.","full_name":"Gauto, Diego F."},{"last_name":"Estrozi","first_name":"Leandro F.","full_name":"Estrozi, Leandro F."},{"full_name":"Schwieters, Charles D.","first_name":"Charles D.","last_name":"Schwieters"},{"full_name":"Effantin, Gregory","first_name":"Gregory","last_name":"Effantin"},{"full_name":"Macek, Pavel","last_name":"Macek","first_name":"Pavel"},{"first_name":"Remy","last_name":"Sounier","full_name":"Sounier, Remy"},{"last_name":"Sivertsen","first_name":"Astrid C.","full_name":"Sivertsen, Astrid C."},{"full_name":"Schmidt, Elena","last_name":"Schmidt","first_name":"Elena"},{"full_name":"Kerfah, Rime","first_name":"Rime","last_name":"Kerfah"},{"last_name":"Mas","first_name":"Guillaume","full_name":"Mas, Guillaume"},{"full_name":"Colletier, Jacques-Philippe","last_name":"Colletier","first_name":"Jacques-Philippe"},{"full_name":"Güntert, Peter","first_name":"Peter","last_name":"Güntert"},{"full_name":"Favier, Adrien","first_name":"Adrien","last_name":"Favier"},{"first_name":"Guy","last_name":"Schoehn","full_name":"Schoehn, Guy"},{"orcid":"0000-0002-9350-7606","first_name":"Paul","last_name":"Schanda","id":"7B541462-FAF6-11E9-A490-E8DFE5697425","full_name":"Schanda, Paul"},{"first_name":"Jerome","last_name":"Boisbouvier","full_name":"Boisbouvier, Jerome"}],"article_type":"original","publisher":"Springer Nature","abstract":[{"text":"Atomic-resolution structure determination is crucial for understanding protein function. Cryo-EM and NMR spectroscopy both provide structural information, but currently cryo-EM does not routinely give access to atomic-level structural data, and, generally, NMR structure determination is restricted to small (<30 kDa) proteins. We introduce an integrated structure determination approach that simultaneously uses NMR and EM data to overcome the limits of each of these methods. The approach enables structure determination of the 468 kDa large dodecameric aminopeptidase TET2 to a precision and accuracy below 1 Å by combining secondary-structure information obtained from near-complete magic-angle-spinning NMR assignments of the 39 kDa-large subunits, distance restraints from backbone amides and ILV methyl groups, and a 4.1 Å resolution EM map. The resulting structure exceeds current standards of NMR and EM structure determination in terms of molecular weight and precision. Importantly, the approach is successful even in cases where only medium-resolution cryo-EM data are available.","lang":"eng"}],"title":"Integrated NMR and cryo-EM atomic-resolution structure determination of a half-megadalton enzyme complex","article_number":"2697","type":"journal_article","fulldoi":"https://doi.org/10.1038/s41467-019-10490-9","article_processing_charge":"No"},{"issue":"1","volume":10,"oa_version":"Published Version","citation":{"ista":"Ramananarivo S, Ducrot E, Palacci JA. 2019. Activity-controlled annealing of colloidal monolayers. Nature Communications. 10(1), 3380.","short":"S. Ramananarivo, E. Ducrot, J.A. Palacci, Nature Communications 10 (2019).","ieee":"S. Ramananarivo, E. Ducrot, and J. A. Palacci, “Activity-controlled annealing of colloidal monolayers,” <i>Nature Communications</i>, vol. 10, no. 1. Springer Nature, 2019.","ama":"Ramananarivo S, Ducrot E, Palacci JA. Activity-controlled annealing of colloidal monolayers. <i>Nature Communications</i>. 2019;10(1). doi:<a href=\"https://doi.org/10.1038/s41467-019-11362-y\">10.1038/s41467-019-11362-y</a>","chicago":"Ramananarivo, Sophie, Etienne Ducrot, and Jérémie A Palacci. “Activity-Controlled Annealing of Colloidal Monolayers.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-11362-y\">https://doi.org/10.1038/s41467-019-11362-y</a>.","apa":"Ramananarivo, S., Ducrot, E., &#38; Palacci, J. A. (2019). Activity-controlled annealing of colloidal monolayers. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-11362-y\">https://doi.org/10.1038/s41467-019-11362-y</a>","mla":"Ramananarivo, Sophie, et al. “Activity-Controlled Annealing of Colloidal Monolayers.” <i>Nature Communications</i>, vol. 10, no. 1, 3380, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-11362-y\">10.1038/s41467-019-11362-y</a>."},"date_created":"2021-02-02T13:43:36Z","date_updated":"2023-02-23T13:47:59Z","oa":1,"quality_controlled":"1","month":"07","date_published":"2019-07-29T00:00:00Z","doi":"10.1038/s41467-019-11362-y","day":"29","intvolume":"        10","file":[{"relation":"main_file","creator":"cziletti","file_id":"9061","date_updated":"2021-02-02T13:47:21Z","file_size":2820337,"checksum":"70c6e5d6fbea0932b0669505ab6633ec","date_created":"2021-02-02T13:47:21Z","access_level":"open_access","content_type":"application/pdf","file_name":"2019_NatureComm_Ramananarivo.pdf","success":1}],"language":[{"iso":"eng"}],"status":"public","file_date_updated":"2021-02-02T13:47:21Z","publication_identifier":{"issn":["2041-1723"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"pmid":1,"publication":"Nature Communications","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","external_id":{"pmid":["31358762"],"arxiv":["1909.07382"]},"keyword":["General Biochemistry","Genetics and Molecular Biology","General Physics and Astronomy","General Chemistry"],"extern":"1","year":"2019","author":[{"full_name":"Ramananarivo, Sophie","last_name":"Ramananarivo","first_name":"Sophie"},{"last_name":"Ducrot","first_name":"Etienne","full_name":"Ducrot, Etienne"},{"orcid":"0000-0002-7253-9465","first_name":"Jérémie A","last_name":"Palacci","id":"8fb92548-2b22-11eb-b7c1-a3f0d08d7c7d","full_name":"Palacci, Jérémie A"}],"_id":"9060","scopus_import":"1","publication_status":"published","article_processing_charge":"No","fulldoi":"https://doi.org/10.1038/s41467-019-11362-y","type":"journal_article","ddc":["530"],"article_number":"3380","arxiv":1,"abstract":[{"text":"Molecular motors are essential to the living, generating fluctuations that boost transport and assist assembly. Active colloids, that consume energy to move, hold similar potential for man-made materials controlled by forces generated from within. Yet, their use as a powerhouse in materials science lacks. Here we show a massive acceleration of the annealing of a monolayer of passive beads by moderate addition of self-propelled microparticles. We rationalize our observations with a model of collisions that drive active fluctuations and activate the annealing. The experiment is quantitatively compared with Brownian dynamic simulations that further unveil a dynamical transition in the mechanism of annealing. Active dopants travel uniformly in the system or co-localize at the grain boundaries as a result of the persistence of their motion. Our findings uncover the potential of internal activity to control materials and lay the groundwork for the rise of materials science beyond equilibrium.","lang":"eng"}],"title":"Activity-controlled annealing of colloidal monolayers","publisher":"Springer Nature","article_type":"original","has_accepted_license":"1"},{"year":"2019","related_material":{"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/when-plant-roots-learned-to-follow-gravity/","description":"News on IST Homepage"}]},"external_id":{"isi":["000478576500012"],"pmid":["31375675"]},"publication":"Nature Communications","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","pmid":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"publication_identifier":{"issn":["2041-1723"]},"status":"public","file_date_updated":"2020-07-14T12:47:40Z","file":[{"relation":"main_file","creator":"dernst","date_updated":"2020-07-14T12:47:40Z","file_id":"6798","file_size":6406141,"checksum":"d2c654fdb97f33078f606fe0c298bf6e","date_created":"2019-08-12T07:09:20Z","access_level":"open_access","content_type":"application/pdf","file_name":"2019_NatureComm_Zhang.pdf"}],"language":[{"iso":"eng"}],"intvolume":"        10","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","_id":"261099A6-B435-11E9-9278-68D0E5697425","grant_number":"742985","call_identifier":"H2020"},{"grant_number":"I03630","call_identifier":"FWF","_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants"},{"grant_number":"291734","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme"}],"day":"02","doi":"10.1038/s41467-019-11471-8","date_published":"2019-08-02T00:00:00Z","month":"08","quality_controlled":"1","oa":1,"date_updated":"2025-04-14T07:45:04Z","department":[{"_id":"JiFr"}],"date_created":"2019-08-09T08:46:26Z","citation":{"ista":"Zhang Y, Xiao G, Wang X, Zhang X, Friml J. 2019. Evolution of fast root gravitropism in seed plants. Nature Communications. 10, 3480.","ieee":"Y. Zhang, G. Xiao, X. Wang, X. Zhang, and J. Friml, “Evolution of fast root gravitropism in seed plants,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","short":"Y. Zhang, G. Xiao, X. Wang, X. Zhang, J. Friml, Nature Communications 10 (2019).","ama":"Zhang Y, Xiao G, Wang X, Zhang X, Friml J. Evolution of fast root gravitropism in seed plants. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-11471-8\">10.1038/s41467-019-11471-8</a>","mla":"Zhang, Yuzhou, et al. “Evolution of Fast Root Gravitropism in Seed Plants.” <i>Nature Communications</i>, vol. 10, 3480, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-11471-8\">10.1038/s41467-019-11471-8</a>.","apa":"Zhang, Y., Xiao, G., Wang, X., Zhang, X., &#38; Friml, J. (2019). Evolution of fast root gravitropism in seed plants. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-11471-8\">https://doi.org/10.1038/s41467-019-11471-8</a>","chicago":"Zhang, Yuzhou, G Xiao, X Wang, Xixi Zhang, and Jiří Friml. “Evolution of Fast Root Gravitropism in Seed Plants.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-11471-8\">https://doi.org/10.1038/s41467-019-11471-8</a>."},"oa_version":"Published Version","volume":10,"has_accepted_license":"1","article_type":"original","title":"Evolution of fast root gravitropism in seed plants","publisher":"Springer Nature","abstract":[{"text":"An important adaptation during colonization of land by plants is gravitropic growth of roots, which enabled roots to reach water and nutrients, and firmly anchor plants in the ground. Here we provide insights into the evolution of an efficient root gravitropic mechanism in the seed plants. Architectural innovation, with gravity perception constrained in the root tips\r\nalong with a shootward transport route for the phytohormone auxin, appeared only upon the emergence of seed plants. Interspecies complementation and protein domain swapping revealed functional innovations within the PIN family of auxin transporters leading to the evolution of gravitropism-specific PINs. The unique apical/shootward subcellular localization of PIN proteins is the major evolutionary innovation that connected the anatomically separated sites of gravity perception and growth response via the mobile auxin signal. We conclude that the crucial anatomical and functional components emerged hand-in-hand to facilitate the evolution of fast gravitropic response, which is one of the major adaptations of seed plants to dry land.","lang":"eng"}],"article_number":"3480","ddc":["580"],"type":"journal_article","fulldoi":"https://doi.org/10.1038/s41467-019-11471-8","article_processing_charge":"No","ec_funded":1,"isi":1,"publication_status":"published","_id":"6778","scopus_import":"1","author":[{"first_name":"Yuzhou","last_name":"Zhang","orcid":"0000-0003-2627-6956","full_name":"Zhang, Yuzhou","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87"},{"first_name":"G","last_name":"Xiao","full_name":"Xiao, G"},{"first_name":"X","last_name":"Wang","full_name":"Wang, X"},{"last_name":"Zhang","first_name":"Xixi","orcid":"0000-0001-7048-4627","full_name":"Zhang, Xixi","id":"61A66458-47E9-11EA-85BA-8AEAAF14E49A"},{"id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří","orcid":"0000-0002-8302-7596","last_name":"Friml","first_name":"Jiří"}]},{"article_processing_charge":"No","type":"journal_article","article_number":"5744","ddc":["570"],"fulldoi":"https://doi.org/10.1038/s41467-019-13702-4","abstract":[{"lang":"eng","text":"During bacterial cell division, the tubulin-homolog FtsZ forms a ring-like structure at the center of the cell. This Z-ring not only organizes the division machinery, but treadmilling of FtsZ filaments was also found to play a key role in distributing proteins at the division site. What regulates the architecture, dynamics and stability of the Z-ring is currently unknown, but FtsZ-associated proteins are known to play an important role. Here, using an in vitro reconstitution approach, we studied how the well-conserved protein ZapA affects FtsZ treadmilling and filament organization into large-scale patterns. Using high-resolution fluorescence microscopy and quantitative image analysis, we found that ZapA cooperatively increases the spatial order of the filament network, but binds only transiently to FtsZ filaments and has no effect on filament length and treadmilling velocity. Together, our data provides a model for how FtsZ-associated proteins can increase the precision and stability of the bacterial cell division machinery in a switch-like manner."}],"title":"Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA","publisher":"Springer Nature","has_accepted_license":"1","article_type":"original","author":[{"full_name":"Dos Santos Caldas, Paulo R","id":"38FCDB4C-F248-11E8-B48F-1D18A9856A87","first_name":"Paulo R","last_name":"Dos Santos Caldas","orcid":"0000-0001-6730-4461"},{"first_name":"Maria D","last_name":"Lopez Pelegrin","id":"319AA9CE-F248-11E8-B48F-1D18A9856A87","full_name":"Lopez Pelegrin, Maria D"},{"full_name":"Pearce, Daniel J. G.","last_name":"Pearce","first_name":"Daniel J. G."},{"id":"3EA1010E-F248-11E8-B48F-1D18A9856A87","full_name":"Budanur, Nazmi B","orcid":"0000-0003-0423-5010","last_name":"Budanur","first_name":"Nazmi B"},{"full_name":"Brugués, Jan","first_name":"Jan","last_name":"Brugués"},{"orcid":"0000-0001-7309-9724","last_name":"Loose","first_name":"Martin","id":"462D4284-F248-11E8-B48F-1D18A9856A87","full_name":"Loose, Martin"}],"scopus_import":"1","_id":"7197","publication_status":"published","ec_funded":1,"isi":1,"status":"public","file_date_updated":"2020-07-14T12:47:53Z","publication_identifier":{"issn":["2041-1723"]},"intvolume":"        10","corr_author":"1","language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","file_name":"2019_NatureComm_Caldas.pdf","checksum":"a1b44b427ba341383197790d0e8789fa","date_created":"2019-12-23T07:34:56Z","access_level":"open_access","creator":"dernst","file_id":"7208","date_updated":"2020-07-14T12:47:53Z","file_size":8488733,"relation":"main_file"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"external_id":{"isi":["000503009300001"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication":"Nature Communications","related_material":{"record":[{"status":"public","id":"8358","relation":"dissertation_contains"}]},"year":"2019","acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"}],"volume":10,"oa_version":"Published Version","date_created":"2019-12-20T12:22:57Z","department":[{"_id":"MaLo"},{"_id":"BjHo"}],"citation":{"chicago":"Dos Santos Caldas, Paulo R, Maria D Lopez Pelegrin, Daniel J. G. Pearce, Nazmi B Budanur, Jan Brugués, and Martin Loose. “Cooperative Ordering of Treadmilling Filaments in Cytoskeletal Networks of FtsZ and Its Crosslinker ZapA.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-13702-4\">https://doi.org/10.1038/s41467-019-13702-4</a>.","mla":"Dos Santos Caldas, Paulo R., et al. “Cooperative Ordering of Treadmilling Filaments in Cytoskeletal Networks of FtsZ and Its Crosslinker ZapA.” <i>Nature Communications</i>, vol. 10, 5744, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-13702-4\">10.1038/s41467-019-13702-4</a>.","apa":"Dos Santos Caldas, P. R., Lopez Pelegrin, M. D., Pearce, D. J. G., Budanur, N. B., Brugués, J., &#38; Loose, M. (2019). Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-13702-4\">https://doi.org/10.1038/s41467-019-13702-4</a>","ama":"Dos Santos Caldas PR, Lopez Pelegrin MD, Pearce DJG, Budanur NB, Brugués J, Loose M. Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-13702-4\">10.1038/s41467-019-13702-4</a>","short":"P.R. Dos Santos Caldas, M.D. Lopez Pelegrin, D.J.G. Pearce, N.B. Budanur, J. Brugués, M. Loose, Nature Communications 10 (2019).","ieee":"P. R. Dos Santos Caldas, M. D. Lopez Pelegrin, D. J. G. Pearce, N. B. Budanur, J. Brugués, and M. Loose, “Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","ista":"Dos Santos Caldas PR, Lopez Pelegrin MD, Pearce DJG, Budanur NB, Brugués J, Loose M. 2019. Cooperative ordering of treadmilling filaments in cytoskeletal networks of FtsZ and its crosslinker ZapA. Nature Communications. 10, 5744."},"month":"12","date_published":"2019-12-17T00:00:00Z","date_updated":"2026-04-08T07:26:30Z","oa":1,"quality_controlled":"1","project":[{"name":"Self-Organization of the Bacterial Cell","_id":"2595697A-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"679239"},{"_id":"260D98C8-B435-11E9-9278-68D0E5697425","name":"Reconstitution of Bacterial Cell Division Using Purified Components"}],"day":"17","doi":"10.1038/s41467-019-13702-4"},{"volume":10,"oa_version":"Published Version","date_created":"2020-01-15T12:12:26Z","citation":{"mla":"Kwak, Won-Jin, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries by Singlet Oxygen.” <i>Nature Communications</i>, vol. 10, 1380, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-09399-0\">10.1038/s41467-019-09399-0</a>.","apa":"Kwak, W.-J., Kim, H., Petit, Y. K., Leypold, C., Nguyen, T. T., Mahne, N., … Sun, Y.-K. (2019). Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-09399-0\">https://doi.org/10.1038/s41467-019-09399-0</a>","chicago":"Kwak, Won-Jin, Hun Kim, Yann K. Petit, Christian Leypold, Trung Thien Nguyen, Nika Mahne, Paul Redfern, et al. “Deactivation of Redox Mediators in Lithium-Oxygen Batteries by Singlet Oxygen.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-09399-0\">https://doi.org/10.1038/s41467-019-09399-0</a>.","ama":"Kwak W-J, Kim H, Petit YK, et al. Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-09399-0\">10.1038/s41467-019-09399-0</a>","ieee":"W.-J. Kwak <i>et al.</i>, “Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","short":"W.-J. Kwak, H. Kim, Y.K. Petit, C. Leypold, T.T. Nguyen, N. Mahne, P. Redfern, L.A. Curtiss, H.-G. Jung, S.M. Borisov, S.A. Freunberger, Y.-K. Sun, Nature Communications 10 (2019).","ista":"Kwak W-J, Kim H, Petit YK, Leypold C, Nguyen TT, Mahne N, Redfern P, Curtiss LA, Jung H-G, Borisov SM, Freunberger SA, Sun Y-K. 2019. Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen. Nature Communications. 10, 1380."},"month":"03","date_published":"2019-03-26T00:00:00Z","date_updated":"2021-01-12T08:12:44Z","oa":1,"quality_controlled":"1","day":"26","doi":"10.1038/s41467-019-09399-0","status":"public","file_date_updated":"2020-07-14T12:47:55Z","publication_identifier":{"issn":["2041-1723"]},"intvolume":"        10","file":[{"access_level":"open_access","date_created":"2020-01-22T15:58:54Z","checksum":"123dd33e7f26761c82c74e10811a1e4d","content_type":"application/pdf","file_name":"2019_NatureComm_Kwak.pdf","relation":"main_file","file_size":1003676,"date_updated":"2020-07-14T12:47:55Z","creator":"dernst","file_id":"7355"}],"language":[{"iso":"eng"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Nature Communications","year":"2019","extern":"1","author":[{"last_name":"Kwak","first_name":"Won-Jin","full_name":"Kwak, Won-Jin"},{"first_name":"Hun","last_name":"Kim","full_name":"Kim, Hun"},{"last_name":"Petit","first_name":"Yann K.","full_name":"Petit, Yann K."},{"full_name":"Leypold, Christian","last_name":"Leypold","first_name":"Christian"},{"full_name":"Nguyen, Trung Thien","last_name":"Nguyen","first_name":"Trung Thien"},{"first_name":"Nika","last_name":"Mahne","full_name":"Mahne, Nika"},{"first_name":"Paul","last_name":"Redfern","full_name":"Redfern, Paul"},{"last_name":"Curtiss","first_name":"Larry A.","full_name":"Curtiss, Larry A."},{"full_name":"Jung, Hun-Gi","first_name":"Hun-Gi","last_name":"Jung"},{"full_name":"Borisov, Sergey M.","first_name":"Sergey M.","last_name":"Borisov"},{"full_name":"Freunberger, Stefan Alexander","id":"A8CA28E6-CE23-11E9-AD2D-EC27E6697425","last_name":"Freunberger","first_name":"Stefan Alexander","orcid":"0000-0003-2902-5319"},{"first_name":"Yang-Kook","last_name":"Sun","full_name":"Sun, Yang-Kook"}],"_id":"7280","publication_status":"published","article_processing_charge":"No","type":"journal_article","article_number":"1380","ddc":["540"],"fulldoi":"https://doi.org/10.1038/s41467-019-09399-0","abstract":[{"lang":"eng","text":"Non-aqueous lithium-oxygen batteries cycle by forming lithium peroxide during discharge and oxidizing it during recharge. The significant problem of oxidizing the solid insulating lithium peroxide can greatly be facilitated by incorporating redox mediators that shuttle electron-holes between the porous substrate and lithium peroxide. Redox mediator stability is thus key for energy efficiency, reversibility, and cycle life. However, the gradual deactivation of redox mediators during repeated cycling has not conclusively been explained. Here, we show that organic redox mediators are predominantly decomposed by singlet oxygen that forms during cycling. Their reaction with superoxide, previously assumed to mainly trigger their degradation, peroxide, and dioxygen, is orders of magnitude slower in comparison. The reduced form of the mediator is markedly more reactive towards singlet oxygen than the oxidized form, from which we derive reaction mechanisms supported by density functional theory calculations. Redox mediators must thus be designed for stability against singlet oxygen."}],"publisher":"Springer Nature","title":"Deactivation of redox mediators in lithium-oxygen batteries by singlet oxygen","has_accepted_license":"1","article_type":"original"},{"scopus_import":"1","_id":"17916","author":[{"full_name":"Zang, Yaping","first_name":"Yaping","last_name":"Zang"},{"last_name":"Zou","first_name":"Qi","full_name":"Zou, Qi"},{"full_name":"Fu, Tianren","first_name":"Tianren","last_name":"Fu"},{"full_name":"Ng, Fay","last_name":"Ng","first_name":"Fay"},{"first_name":"Brandon","last_name":"Fowler","full_name":"Fowler, Brandon"},{"last_name":"Yang","first_name":"Jingjing","full_name":"Yang, Jingjing"},{"full_name":"Li, Hexing","last_name":"Li","first_name":"Hexing"},{"full_name":"Steigerwald, Michael L.","first_name":"Michael L.","last_name":"Steigerwald"},{"first_name":"Colin","last_name":"Nuckolls","full_name":"Nuckolls, Colin"},{"orcid":"0000-0002-6957-6089","last_name":"Venkataraman","first_name":"Latha","id":"9ebb78a5-cc0d-11ee-8322-fae086a32caf","full_name":"Venkataraman, Latha"}],"publication_status":"published","article_processing_charge":"Yes","title":"Directing isomerization reactions of cumulenes with electric fields","publisher":"Springer Nature","abstract":[{"lang":"eng","text":"Electric fields have been proposed as having a distinct ability to catalyze chemical reactions through the stabilization of polar or ionic intermediate transition states. Although field-assisted catalysis is being researched, the ability to catalyze reactions in solution using electric fields remains elusive and the understanding of mechanisms of such catalysis is sparse. Here we show that an electric field can catalyze the cis-to-trans isomerization of [3]cumulene derivatives in solution, in a scanning tunneling microscope. We further show that the external electric field can alter the thermodynamics inhibiting the trans-to-cis reverse reaction, endowing the selectivity toward trans isomer. Using density functional theory-based calculations, we find that the applied electric field promotes a zwitterionic resonance form, which ensures a lower energy transition state for the isomerization reaction. The field also stabilizes the trans form, relative to the cis, dictating the cis/trans thermodynamics, driving the equilibrium product exclusively toward the trans."}],"article_type":"original","type":"journal_article","article_number":"4482","OA_place":"publisher","fulldoi":"https://doi.org/10.1038/s41467-019-12487-w","date_created":"2024-09-09T07:40:44Z","main_file_link":[{"url":"https://doi.org/10.1038/s41467-019-12487-w","open_access":"1"}],"citation":{"short":"Y. Zang, Q. Zou, T. Fu, F. Ng, B. Fowler, J. Yang, H. Li, M.L. Steigerwald, C. Nuckolls, L. Venkataraman, Nature Communications 10 (2019).","ieee":"Y. Zang <i>et al.</i>, “Directing isomerization reactions of cumulenes with electric fields,” <i>Nature Communications</i>, vol. 10. Springer Nature, 2019.","ista":"Zang Y, Zou Q, Fu T, Ng F, Fowler B, Yang J, Li H, Steigerwald ML, Nuckolls C, Venkataraman L. 2019. Directing isomerization reactions of cumulenes with electric fields. Nature Communications. 10, 4482.","chicago":"Zang, Yaping, Qi Zou, Tianren Fu, Fay Ng, Brandon Fowler, Jingjing Yang, Hexing Li, Michael L. Steigerwald, Colin Nuckolls, and Latha Venkataraman. “Directing Isomerization Reactions of Cumulenes with Electric Fields.” <i>Nature Communications</i>. Springer Nature, 2019. <a href=\"https://doi.org/10.1038/s41467-019-12487-w\">https://doi.org/10.1038/s41467-019-12487-w</a>.","apa":"Zang, Y., Zou, Q., Fu, T., Ng, F., Fowler, B., Yang, J., … Venkataraman, L. (2019). Directing isomerization reactions of cumulenes with electric fields. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-019-12487-w\">https://doi.org/10.1038/s41467-019-12487-w</a>","mla":"Zang, Yaping, et al. “Directing Isomerization Reactions of Cumulenes with Electric Fields.” <i>Nature Communications</i>, vol. 10, 4482, Springer Nature, 2019, doi:<a href=\"https://doi.org/10.1038/s41467-019-12487-w\">10.1038/s41467-019-12487-w</a>.","ama":"Zang Y, Zou Q, Fu T, et al. Directing isomerization reactions of cumulenes with electric fields. <i>Nature Communications</i>. 2019;10. doi:<a href=\"https://doi.org/10.1038/s41467-019-12487-w\">10.1038/s41467-019-12487-w</a>"},"volume":10,"OA_type":"gold","oa_version":"Published Version","day":"02","doi":"10.1038/s41467-019-12487-w","month":"10","date_published":"2019-10-02T00:00:00Z","date_updated":"2024-12-10T12:32:33Z","oa":1,"quality_controlled":"1","status":"public","publication_identifier":{"issn":["2041-1723"]},"intvolume":"        10","language":[{"iso":"eng"}],"year":"2019","DOAJ_listed":"1","extern":"1","external_id":{"pmid":["31578333"]},"pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Nature Communications"},{"publication_status":"published","_id":"14284","scopus_import":"1","author":[{"first_name":"Bastian","last_name":"Bräuning","full_name":"Bräuning, Bastian"},{"first_name":"Eva","last_name":"Bertosin","full_name":"Bertosin, Eva"},{"first_name":"Florian M","last_name":"Praetorius","id":"dfec9381-4341-11ee-8fd8-faa02bba7d62","full_name":"Praetorius, Florian M"},{"last_name":"Ihling","first_name":"Christian","full_name":"Ihling, Christian"},{"last_name":"Schatt","first_name":"Alexandra","full_name":"Schatt, Alexandra"},{"first_name":"Agnes","last_name":"Adler","full_name":"Adler, Agnes"},{"last_name":"Richter","first_name":"Klaus","full_name":"Richter, Klaus"},{"full_name":"Sinz, Andrea","first_name":"Andrea","last_name":"Sinz"},{"full_name":"Dietz, Hendrik","first_name":"Hendrik","last_name":"Dietz"},{"last_name":"Groll","first_name":"Michael","full_name":"Groll, Michael"}],"title":"Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB","publisher":"Springer Nature","abstract":[{"text":"Pore-forming toxins (PFT) are virulence factors that transform from soluble to membrane-bound states. The Yersinia YaxAB system represents a family of binary α-PFTs with orthologues in human, insect, and plant pathogens, with unknown structures. YaxAB was shown to be cytotoxic and likely involved in pathogenesis, though the molecular basis for its two-component lytic mechanism remains elusive. Here, we present crystal structures of YaxA and YaxB, together with a cryo-electron microscopy map of the YaxAB complex. Our structures reveal a pore predominantly composed of decamers of YaxA–YaxB heterodimers. Both subunits bear membrane-active moieties, but only YaxA is capable of binding to membranes by itself. YaxB can subsequently be recruited to membrane-associated YaxA and induced to present its lytic transmembrane helices. Pore formation can progress by further oligomerization of YaxA–YaxB dimers. Our results allow for a comparison between pore assemblies belonging to the wider ClyA-like family of α-PFTs, highlighting diverse pore architectures.","lang":"eng"}],"article_type":"original","type":"journal_article","article_number":"1806","fulldoi":"https://doi.org/10.1038/s41467-018-04139-2","article_processing_charge":"No","day":"04","doi":"10.1038/s41467-018-04139-2","month":"05","date_published":"2018-05-04T00:00:00Z","oa":1,"date_updated":"2023-11-07T11:46:12Z","quality_controlled":"1","date_created":"2023-09-06T12:07:33Z","main_file_link":[{"url":"https://doi.org/10.1038/s41467-018-04139-2","open_access":"1"}],"citation":{"chicago":"Bräuning, Bastian, Eva Bertosin, Florian M Praetorius, Christian Ihling, Alexandra Schatt, Agnes Adler, Klaus Richter, Andrea Sinz, Hendrik Dietz, and Michael Groll. “Structure and Mechanism of the Two-Component α-Helical Pore-Forming Toxin YaxAB.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-04139-2\">https://doi.org/10.1038/s41467-018-04139-2</a>.","apa":"Bräuning, B., Bertosin, E., Praetorius, F. M., Ihling, C., Schatt, A., Adler, A., … Groll, M. (2018). Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-04139-2\">https://doi.org/10.1038/s41467-018-04139-2</a>","mla":"Bräuning, Bastian, et al. “Structure and Mechanism of the Two-Component α-Helical Pore-Forming Toxin YaxAB.” <i>Nature Communications</i>, vol. 9, 1806, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-04139-2\">10.1038/s41467-018-04139-2</a>.","ama":"Bräuning B, Bertosin E, Praetorius FM, et al. Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-04139-2\">10.1038/s41467-018-04139-2</a>","short":"B. Bräuning, E. Bertosin, F.M. Praetorius, C. Ihling, A. Schatt, A. Adler, K. Richter, A. Sinz, H. Dietz, M. Groll, Nature Communications 9 (2018).","ieee":"B. Bräuning <i>et al.</i>, “Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","ista":"Bräuning B, Bertosin E, Praetorius FM, Ihling C, Schatt A, Adler A, Richter K, Sinz A, Dietz H, Groll M. 2018. Structure and mechanism of the two-component α-helical pore-forming toxin YaxAB. Nature Communications. 9, 1806."},"volume":9,"oa_version":"Published Version","year":"2018","extern":"1","keyword":["General Physics and Astronomy","General Biochemistry","Genetics and Molecular Biology","General Chemistry","Multidisciplinary"],"external_id":{"pmid":["29728606"]},"pmid":1,"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publication":"Nature Communications","status":"public","publication_identifier":{"issn":["2041-1723"]},"intvolume":"         9","language":[{"iso":"eng"}]},{"article_processing_charge":"No","abstract":[{"text":"G-protein-coupled receptors (GPCRs) form the largest receptor family, relay environmental stimuli to changes in cell behavior and represent prime drug targets. Many GPCRs are classified as orphan receptors because of the limited knowledge on their ligands and coupling to cellular signaling machineries. Here, we engineer a library of 63 chimeric receptors that contain the signaling domains of human orphan and understudied GPCRs functionally linked to the light-sensing domain of rhodopsin. Upon stimulation with visible light, we identify activation of canonical cell signaling pathways, including cAMP-, Ca2+-, MAPK/ERK-, and Rho-dependent pathways, downstream of the engineered receptors. For the human pseudogene GPR33, we resurrect a signaling function that supports its hypothesized role as a pathogen entry site. These results demonstrate that substituting unknown chemical activators with a light switch can reveal information about protein function and provide an optically controlled protein library for exploring the physiology and therapeutic potential of understudied GPCRs.","lang":"eng"}],"publisher":"Springer Nature","title":"Optical functionalization of human class A orphan G-protein-coupled receptors","has_accepted_license":"1","fulldoi":"https://doi.org/10.1038/s41467-018-04342-1","type":"journal_article","article_number":"1950","ddc":["570"],"scopus_import":"1","_id":"5984","author":[{"first_name":"Maurizio","last_name":"Morri","id":"4863116E-F248-11E8-B48F-1D18A9856A87","full_name":"Morri, Maurizio"},{"id":"3D9C5D30-F248-11E8-B48F-1D18A9856A87","full_name":"Sanchez-Romero, Inmaculada","last_name":"Sanchez-Romero","first_name":"Inmaculada"},{"first_name":"Alexandra-Madelaine","last_name":"Tichy","full_name":"Tichy, Alexandra-Madelaine","id":"29D8BB2C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kainrath, Stephanie","id":"32CFBA64-F248-11E8-B48F-1D18A9856A87","first_name":"Stephanie","last_name":"Kainrath"},{"full_name":"Gerrard, Elliot J.","last_name":"Gerrard","first_name":"Elliot J."},{"full_name":"Hirschfeld, Priscila","id":"435ACB3A-F248-11E8-B48F-1D18A9856A87","last_name":"Hirschfeld","first_name":"Priscila"},{"full_name":"Schwarz, Jan","id":"346C1EC6-F248-11E8-B48F-1D18A9856A87","last_name":"Schwarz","first_name":"Jan"},{"orcid":"0000-0002-8023-9315","first_name":"Harald L","last_name":"Janovjak","id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","full_name":"Janovjak, Harald L"}],"isi":1,"ec_funded":1,"publication_status":"published","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","image":"/images/cc_by.png","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode"},"intvolume":"         9","language":[{"iso":"eng"}],"file":[{"checksum":"8325fcc194264af4749e662a73bf66b5","access_level":"open_access","date_created":"2019-02-14T10:58:29Z","file_name":"2018_Springer_Morri.pdf","content_type":"application/pdf","relation":"main_file","file_id":"5985","creator":"kschuh","date_updated":"2020-07-14T12:47:14Z","file_size":1349914}],"status":"public","file_date_updated":"2020-07-14T12:47:14Z","publication_identifier":{"issn":["2041-1723"]},"year":"2018","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publication":"Nature Communications","external_id":{"isi":["000432280000006"]},"citation":{"ama":"Morri M, Sanchez-Romero I, Tichy A-M, et al. Optical functionalization of human class A orphan G-protein-coupled receptors. <i>Nature Communications</i>. 2018;9(1). doi:<a href=\"https://doi.org/10.1038/s41467-018-04342-1\">10.1038/s41467-018-04342-1</a>","apa":"Morri, M., Sanchez-Romero, I., Tichy, A.-M., Kainrath, S., Gerrard, E. J., Hirschfeld, P., … Janovjak, H. L. (2018). Optical functionalization of human class A orphan G-protein-coupled receptors. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-04342-1\">https://doi.org/10.1038/s41467-018-04342-1</a>","mla":"Morri, Maurizio, et al. “Optical Functionalization of Human Class A Orphan G-Protein-Coupled Receptors.” <i>Nature Communications</i>, vol. 9, no. 1, 1950, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-04342-1\">10.1038/s41467-018-04342-1</a>.","chicago":"Morri, Maurizio, Inmaculada Sanchez-Romero, Alexandra-Madelaine Tichy, Stephanie Kainrath, Elliot J. Gerrard, Priscila Hirschfeld, Jan Schwarz, and Harald L Janovjak. “Optical Functionalization of Human Class A Orphan G-Protein-Coupled Receptors.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-04342-1\">https://doi.org/10.1038/s41467-018-04342-1</a>.","ista":"Morri M, Sanchez-Romero I, Tichy A-M, Kainrath S, Gerrard EJ, Hirschfeld P, Schwarz J, Janovjak HL. 2018. Optical functionalization of human class A orphan G-protein-coupled receptors. Nature Communications. 9(1), 1950.","ieee":"M. Morri <i>et al.</i>, “Optical functionalization of human class A orphan G-protein-coupled receptors,” <i>Nature Communications</i>, vol. 9, no. 1. Springer Nature, 2018.","short":"M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018)."},"date_created":"2019-02-14T10:50:24Z","department":[{"_id":"HaJa"},{"_id":"CaGu"},{"_id":"MiSi"}],"volume":9,"issue":"1","oa_version":"Published Version","doi":"10.1038/s41467-018-04342-1","project":[{"call_identifier":"FP7","grant_number":"303564","name":"Microbial Ion Channels for Synthetic Neurobiology","_id":"25548C20-B435-11E9-9278-68D0E5697425"},{"_id":"255A6082-B435-11E9-9278-68D0E5697425","name":"Molecular Drug Targets","grant_number":"W1232-B24","call_identifier":"FWF"}],"day":"01","date_updated":"2025-04-15T07:22:42Z","oa":1,"quality_controlled":"1","month":"12","date_published":"2018-12-01T00:00:00Z"},{"date_updated":"2021-01-12T08:15:02Z","oa":1,"quality_controlled":"1","month":"12","date_published":"2018-12-20T00:00:00Z","doi":"10.1038/s41467-018-07862-y","day":"20","volume":9,"oa_version":"Published Version","citation":{"ista":"Yap CX, Sidorenko J, Wu Y, Kemper KE, Yang J, Wray NR, Robinson MR, Visscher PM. 2018. Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. Nature Communications. 9, 5407.","short":"C.X. Yap, J. Sidorenko, Y. Wu, K.E. Kemper, J. Yang, N.R. Wray, M.R. Robinson, P.M. Visscher, Nature Communications 9 (2018).","ieee":"C. X. Yap <i>et al.</i>, “Dissection of genetic variation and evidence for pleiotropy in male pattern baldness,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","ama":"Yap CX, Sidorenko J, Wu Y, et al. Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-07862-y\">10.1038/s41467-018-07862-y</a>","chicago":"Yap, Chloe X., Julia Sidorenko, Yang Wu, Kathryn E. Kemper, Jian Yang, Naomi R. Wray, Matthew Richard Robinson, and Peter M. Visscher. “Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-07862-y\">https://doi.org/10.1038/s41467-018-07862-y</a>.","apa":"Yap, C. X., Sidorenko, J., Wu, Y., Kemper, K. E., Yang, J., Wray, N. R., … Visscher, P. M. (2018). Dissection of genetic variation and evidence for pleiotropy in male pattern baldness. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-07862-y\">https://doi.org/10.1038/s41467-018-07862-y</a>","mla":"Yap, Chloe X., et al. “Dissection of Genetic Variation and Evidence for Pleiotropy in Male Pattern Baldness.” <i>Nature Communications</i>, vol. 9, 5407, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-07862-y\">10.1038/s41467-018-07862-y</a>."},"date_created":"2020-04-30T10:41:19Z","main_file_link":[{"url":"https://doi.org/10.1038/s41467-018-07862-y","open_access":"1"}],"publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","extern":"1","year":"2018","intvolume":"         9","language":[{"iso":"eng"}],"status":"public","publication_identifier":{"issn":["2041-1723"]},"publication_status":"published","author":[{"last_name":"Yap","first_name":"Chloe X.","full_name":"Yap, Chloe X."},{"full_name":"Sidorenko, Julia","first_name":"Julia","last_name":"Sidorenko"},{"full_name":"Wu, Yang","last_name":"Wu","first_name":"Yang"},{"last_name":"Kemper","first_name":"Kathryn E.","full_name":"Kemper, Kathryn E."},{"last_name":"Yang","first_name":"Jian","full_name":"Yang, Jian"},{"full_name":"Wray, Naomi R.","last_name":"Wray","first_name":"Naomi R."},{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","first_name":"Matthew Richard","last_name":"Robinson","orcid":"0000-0001-8982-8813"},{"last_name":"Visscher","first_name":"Peter M.","full_name":"Visscher, Peter M."}],"_id":"7712","fulldoi":"https://doi.org/10.1038/s41467-018-07862-y","type":"journal_article","article_number":"5407","abstract":[{"text":"Male pattern baldness (MPB) is a sex-limited, age-related, complex trait. We study MPB genetics in 205,327 European males from the UK Biobank. Here we show that MPB is strongly heritable and polygenic, with pedigree-heritability of 0.62 (SE = 0.03) estimated from close relatives, and SNP-heritability of 0.39 (SE = 0.01) from conventionally-unrelated males. We detect 624 near-independent genome-wide loci, contributing SNP-heritability of 0.25 (SE = 0.01), of which 26 X-chromosome loci explain 11.6%. Autosomal genetic variance is enriched for common variants and regions of lower linkage disequilibrium. We identify plausible genetic correlations between MPB and multiple sex-limited markers of earlier puberty, increased bone mineral density (rg = 0.15) and pancreatic β-cell function (rg = 0.12). Correlations with reproductive traits imply an effect on fitness, consistent with an estimated linear selection gradient of -0.018 per MPB standard deviation. Overall, we provide genetic insights into MPB: a phenotype of interest in its own right, with value as a model sex-limited, complex trait.","lang":"eng"}],"publisher":"Springer Nature","title":"Dissection of genetic variation and evidence for pleiotropy in male pattern baldness","article_type":"original","article_processing_charge":"No"},{"day":"14","doi":"10.1038/s41467-018-04191-y","month":"05","date_published":"2018-05-14T00:00:00Z","oa":1,"date_updated":"2021-01-12T08:15:02Z","quality_controlled":"1","date_created":"2020-04-30T10:41:36Z","main_file_link":[{"url":"https://doi.org/10.1038/s41467-018-04191-y","open_access":"1"}],"citation":{"chicago":"Guo, Jing, Yang Wu, Zhihong Zhu, Zhili Zheng, Maciej Trzaskowski, Jian Zeng, Matthew Richard Robinson, Peter M. Visscher, and Jian Yang. “Global Genetic Differentiation of Complex Traits Shaped by Natural Selection in Humans.” <i>Nature Communications</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41467-018-04191-y\">https://doi.org/10.1038/s41467-018-04191-y</a>.","apa":"Guo, J., Wu, Y., Zhu, Z., Zheng, Z., Trzaskowski, M., Zeng, J., … Yang, J. (2018). Global genetic differentiation of complex traits shaped by natural selection in humans. <i>Nature Communications</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41467-018-04191-y\">https://doi.org/10.1038/s41467-018-04191-y</a>","mla":"Guo, Jing, et al. “Global Genetic Differentiation of Complex Traits Shaped by Natural Selection in Humans.” <i>Nature Communications</i>, vol. 9, 1865, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41467-018-04191-y\">10.1038/s41467-018-04191-y</a>.","ama":"Guo J, Wu Y, Zhu Z, et al. Global genetic differentiation of complex traits shaped by natural selection in humans. <i>Nature Communications</i>. 2018;9. doi:<a href=\"https://doi.org/10.1038/s41467-018-04191-y\">10.1038/s41467-018-04191-y</a>","short":"J. Guo, Y. Wu, Z. Zhu, Z. Zheng, M. Trzaskowski, J. Zeng, M.R. Robinson, P.M. Visscher, J. Yang, Nature Communications 9 (2018).","ieee":"J. Guo <i>et al.</i>, “Global genetic differentiation of complex traits shaped by natural selection in humans,” <i>Nature Communications</i>, vol. 9. Springer Nature, 2018.","ista":"Guo J, Wu Y, Zhu Z, Zheng Z, Trzaskowski M, Zeng J, Robinson MR, Visscher PM, Yang J. 2018. Global genetic differentiation of complex traits shaped by natural selection in humans. Nature Communications. 9, 1865."},"volume":9,"oa_version":"Published Version","year":"2018","extern":"1","publication":"Nature Communications","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","publication_identifier":{"issn":["2041-1723"]},"intvolume":"         9","language":[{"iso":"eng"}],"publication_status":"published","_id":"7713","author":[{"last_name":"Guo","first_name":"Jing","full_name":"Guo, Jing"},{"full_name":"Wu, Yang","first_name":"Yang","last_name":"Wu"},{"full_name":"Zhu, Zhihong","last_name":"Zhu","first_name":"Zhihong"},{"first_name":"Zhili","last_name":"Zheng","full_name":"Zheng, Zhili"},{"first_name":"Maciej","last_name":"Trzaskowski","full_name":"Trzaskowski, Maciej"},{"last_name":"Zeng","first_name":"Jian","full_name":"Zeng, Jian"},{"full_name":"Robinson, Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","first_name":"Matthew Richard","orcid":"0000-0001-8982-8813"},{"full_name":"Visscher, Peter M.","last_name":"Visscher","first_name":"Peter M."},{"first_name":"Jian","last_name":"Yang","full_name":"Yang, Jian"}],"title":"Global genetic differentiation of complex traits shaped by natural selection in humans","abstract":[{"text":"There are mean differences in complex traits among global human populations. We hypothesize that part of the phenotypic differentiation is due to natural selection. To address this hypothesis, we assess the differentiation in allele frequencies of trait-associated SNPs among African, Eastern Asian, and European populations for ten complex traits using data of large sample size (up to ~405,000). We show that SNPs associated with height (P=2.46×10−5), waist-to-hip ratio (P=2.77×10−4), and schizophrenia (P=3.96×10−5) are significantly more differentiated among populations than matched “control” SNPs, suggesting that these trait-associated SNPs have undergone natural selection. We further find that SNPs associated with height (P=2.01×10−6) and schizophrenia (P=5.16×10−18) show significantly higher variance in linkage disequilibrium (LD) scores across populations than control SNPs. Our results support the hypothesis that natural selection has shaped the genetic differentiation of complex traits, such as height and schizophrenia, among worldwide populations.","lang":"eng"}],"publisher":"Springer Nature","article_type":"original","type":"journal_article","article_number":"1865","fulldoi":"https://doi.org/10.1038/s41467-018-04191-y","article_processing_charge":"No"}]