[{"day":"13","year":"2018","volume":4,"external_id":{"pmid":["30455989 "]},"article_type":"original","license":"https://creativecommons.org/licenses/by/4.0/","author":[{"first_name":"Emil","full_name":"Bulatov, Emil","last_name":"Bulatov"},{"last_name":"Sayarova","full_name":"Sayarova, Regina","first_name":"Regina"},{"last_name":"Mingaleeva","full_name":"Mingaleeva, Rimma","first_name":"Rimma"},{"full_name":"Miftakhova, Regina","first_name":"Regina","last_name":"Miftakhova"},{"last_name":"Gomzikova","full_name":"Gomzikova, Marina","first_name":"Marina"},{"full_name":"Ignatev, Iurii","first_name":"Iurii","id":"2ac71786-dc7d-11ea-9b2f-c5ad4b9faff6","last_name":"Ignatev"},{"first_name":"Alexey","full_name":"Petukhov, Alexey","last_name":"Petukhov"},{"first_name":"Pavel","full_name":"Davidovich, Pavel","last_name":"Davidovich"},{"last_name":"Rizvanov","first_name":"Albert","full_name":"Rizvanov, Albert"},{"last_name":"Barlev","first_name":"Nickolai A.","full_name":"Barlev, Nickolai A."}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1038/s41420-018-0120-z"}],"quality_controlled":"1","ddc":["570"],"publisher":"Springer Nature","extern":"1","publication_status":"published","type":"journal_article","date_updated":"2025-07-10T11:51:52Z","has_accepted_license":"1","article_processing_charge":"Yes","title":"Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors","department":[{"_id":"GradSch"},{"_id":"LoSw"}],"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","short":"CC BY (4.0)"},"publication_identifier":{"issn":["2058-7716"]},"DOAJ_listed":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","date_published":"2018-11-13T00:00:00Z","article_number":"103","abstract":[{"lang":"eng","text":"Medicinal bioinorganic chemistry is a thriving field of drug research for cancer treatment. Transition metal complexes coordinated to essential biological scaffolds represent a highly promising class of compounds for design of novel target-specific therapeutics. We report here the biological evaluation of a novel Isatin-Schiff base derivative and its Cu(II) complex in several tumor cell lines by assessing their effects on cellular metabolism, real-time cell proliferation and induction of apoptosis. Further, the impact of compounds on the p53 protein and expression of its target genes, including MDM2, p21/CDKN1A, and PUMA was evaluated. Results obtained in this study provide further evidence in support of our prior data suggesting the p53-mediated mechanism of action for Isatin-Schiff base derivatives and their complexes and also shed light on potential use of these compounds for stimulation of apoptosis in breast cancer cells via activation of the pro-apoptotic PUMA gene."}],"OA_place":"publisher","oa":1,"pmid":1,"publication":"Cell Death Discovery","month":"11","date_created":"2025-04-11T01:31:42Z","oa_version":"Published Version","doi":"10.1038/s41420-018-0120-z","citation":{"ista":"Bulatov E, Sayarova R, Mingaleeva R, Miftakhova R, Gomzikova M, Ignatev I, Petukhov A, Davidovich P, Rizvanov A, Barlev NA. 2018. Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors. Cell Death Discovery. 4, 103.","mla":"Bulatov, Emil, et al. “Isatin-Schiff Base-Copper (II) Complex Induces Cell Death in P53-Positive Tumors.” <i>Cell Death Discovery</i>, vol. 4, 103, Springer Nature, 2018, doi:<a href=\"https://doi.org/10.1038/s41420-018-0120-z\">10.1038/s41420-018-0120-z</a>.","short":"E. Bulatov, R. Sayarova, R. Mingaleeva, R. Miftakhova, M. Gomzikova, I. Ignatev, A. Petukhov, P. Davidovich, A. Rizvanov, N.A. Barlev, Cell Death Discovery 4 (2018).","ama":"Bulatov E, Sayarova R, Mingaleeva R, et al. Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors. <i>Cell Death Discovery</i>. 2018;4. doi:<a href=\"https://doi.org/10.1038/s41420-018-0120-z\">10.1038/s41420-018-0120-z</a>","chicago":"Bulatov, Emil, Regina Sayarova, Rimma Mingaleeva, Regina Miftakhova, Marina Gomzikova, Iurii Ignatev, Alexey Petukhov, Pavel Davidovich, Albert Rizvanov, and Nickolai A. Barlev. “Isatin-Schiff Base-Copper (II) Complex Induces Cell Death in P53-Positive Tumors.” <i>Cell Death Discovery</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41420-018-0120-z\">https://doi.org/10.1038/s41420-018-0120-z</a>.","apa":"Bulatov, E., Sayarova, R., Mingaleeva, R., Miftakhova, R., Gomzikova, M., Ignatev, I., … Barlev, N. A. (2018). Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors. <i>Cell Death Discovery</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41420-018-0120-z\">https://doi.org/10.1038/s41420-018-0120-z</a>","ieee":"E. Bulatov <i>et al.</i>, “Isatin-Schiff base-copper (II) complex induces cell death in p53-positive tumors,” <i>Cell Death Discovery</i>, vol. 4. Springer Nature, 2018."},"_id":"19544","OA_type":"gold","intvolume":"         4","language":[{"iso":"eng"}]}]